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Conserved domains on  [gi|446952627|ref|WP_001029883|]
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MULTISPECIES: translation initiation factor IF-1 [Streptococcus]

Protein Classification

translation initiation factor IF-1( domain architecture ID 10011353)

initiation factor 1 together with initiation factor 2 and 3 play an important role in the correct assembly of the functional initiation complex for protein biosynthesis in prokaryotes

Gene Ontology:  GO:0043022|GO:0019843|GO:0003743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
infA PRK00276
translation initiation factor IF-1; Validated
 1-72 5.34e-47

translation initiation factor IF-1; Validated


:

Pssm-ID: 178954  Cd Length: 72  Bit Score: 143.37  E-value: 5.34e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446952627  1 MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:PRK00276  1 MAKEDVIEMEGTVVEALPNAMFRVELENGHEVLAHISGKMRKNYIRILPGDKVTVELSPYDLTKGRITYRHK 72
 
Name Accession Description Interval E-value
infA PRK00276
translation initiation factor IF-1; Validated
 1-72 5.34e-47

translation initiation factor IF-1; Validated


Pssm-ID: 178954  Cd Length: 72  Bit Score: 143.37  E-value: 5.34e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446952627  1 MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:PRK00276  1 MAKEDVIEMEGTVVEALPNAMFRVELENGHEVLAHISGKMRKNYIRILPGDKVTVELSPYDLTKGRITYRHK 72
infA TIGR00008
translation initiation factor IF-1; This family consists of translation initiation factor IF-1 ...
 3-71 6.02e-39

translation initiation factor IF-1; This family consists of translation initiation factor IF-1 as found in bacteria and chloroplasts. This protein, about 70 residues in length, consists largely of an S1 RNA binding domain (pfam00575). [Protein synthesis, Translation factors]


Pssm-ID: 188015  Cd Length: 69  Bit Score: 122.83  E-value: 6.02e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446952627   3 KDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRF 71
Cdd:TIGR00008  1 KEDKIEMEGKVTESLPNAMFRVELENGHEVLAHISGKIRMHYIRILPGDRVKVELSPYDLTRGRITYRL 69
InfA COG0361
Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; ...
 1-72 1.85e-38

Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; Translation initiation factor IF-1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440130  Cd Length: 73  Bit Score: 121.75  E-value: 1.85e-38
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446952627  1 MA-KDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:COG0361   1 MAkKEDLIEVEGVVEEVLPNARFRVRLENGHERLARISGKMRKNRIRILPGDRVLVEPSPYDLTKGRIVYRYK 73
S1_IF1 cd04451
S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like ...
 7-70 4.79e-36

S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the formation of the first peptide bond. In Escherichia coli, the initiation mechanism requires, in addition to mRNA, fMet-tRNA, and ribosomal subunits, the presence of three additional proteins (initiation factors IF1, IF2, and IF3) and at least one GTP molecule. The three initiation factors influence both the kinetics and the stability of ternary complex formation. IF1 is the smallest of the three factors. IF1 enhances the rate of 70S ribosome subunit association and dissociation and the interaction of 30S ribosomal subunit with IF2 and IF3. It stimulates 30S complex formation. In addition, by binding to the A-site of the 30S ribosomal subunit, IF1 may contribute to the fidelity of the selection of the initiation site of the mRNA.


Pssm-ID: 239898  Cd Length: 64  Bit Score: 115.31  E-value: 4.79e-36
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446952627  7 IEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYR 70
Cdd:cd04451   1 IEMEGVVTEALPNAMFRVELENGHEVLAHISGKMRMNYIRILPGDRVKVELSPYDLTKGRIVYR 64
eIF-1a pfam01176
Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation ...
 8-70 1.34e-28

Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.


Pssm-ID: 460099  Cd Length: 62  Bit Score: 96.69  E-value: 1.34e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446952627   8 EVEGKVVDTMPNAMFTVELENGHQILATVSGKIRkNYIRILAGDRVTVEMSPYDLTRGRITYR 70
Cdd:pfam01176  1 EVIGKVVEALGNNLFEVELDNGHTRLAHIPGKMR-NRIWIKRGDYVLVEPSPYDLTKGRIVYR 62
S1 smart00316
Ribosomal protein S1-like RNA-binding domain;
9-72 8.76e-07

Ribosomal protein S1-like RNA-binding domain;


Pssm-ID: 197648 [Multi-domain]  Cd Length: 72  Bit Score: 41.44  E-value: 8.76e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446952627    9 VEGKVVDTMPNaMFTVELENGHQILATVS----GKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:smart00316  6 VEGTVTEITPG-GAFVDLGNGVEGLIPISelsdKRVKDPEEVLKVGDEVKVKVLSVDEEKGRIILSLK 72
 
Name Accession Description Interval E-value
infA PRK00276
translation initiation factor IF-1; Validated
 1-72 5.34e-47

translation initiation factor IF-1; Validated


Pssm-ID: 178954  Cd Length: 72  Bit Score: 143.37  E-value: 5.34e-47
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446952627  1 MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:PRK00276  1 MAKEDVIEMEGTVVEALPNAMFRVELENGHEVLAHISGKMRKNYIRILPGDKVTVELSPYDLTKGRITYRHK 72
infA TIGR00008
translation initiation factor IF-1; This family consists of translation initiation factor IF-1 ...
 3-71 6.02e-39

translation initiation factor IF-1; This family consists of translation initiation factor IF-1 as found in bacteria and chloroplasts. This protein, about 70 residues in length, consists largely of an S1 RNA binding domain (pfam00575). [Protein synthesis, Translation factors]


Pssm-ID: 188015  Cd Length: 69  Bit Score: 122.83  E-value: 6.02e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446952627   3 KDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRF 71
Cdd:TIGR00008  1 KEDKIEMEGKVTESLPNAMFRVELENGHEVLAHISGKIRMHYIRILPGDRVKVELSPYDLTRGRITYRL 69
InfA COG0361
Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; ...
 1-72 1.85e-38

Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; Translation initiation factor IF-1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440130  Cd Length: 73  Bit Score: 121.75  E-value: 1.85e-38
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446952627  1 MA-KDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:COG0361   1 MAkKEDLIEVEGVVEEVLPNARFRVRLENGHERLARISGKMRKNRIRILPGDRVLVEPSPYDLTKGRIVYRYK 73
infA CHL00010
translation initiation factor 1
 1-72 6.55e-37

translation initiation factor 1


Pssm-ID: 214332  Cd Length: 78  Bit Score: 118.17  E-value: 6.55e-37
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446952627  1 MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:CHL00010  1 MKKENKIEMEGLVTESLPNGMFRVRLDNGCQVLGYISGKIRRNSIRILPGDRVKVELSPYDLTKGRIIYRLR 72
S1_IF1 cd04451
S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like ...
 7-70 4.79e-36

S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the formation of the first peptide bond. In Escherichia coli, the initiation mechanism requires, in addition to mRNA, fMet-tRNA, and ribosomal subunits, the presence of three additional proteins (initiation factors IF1, IF2, and IF3) and at least one GTP molecule. The three initiation factors influence both the kinetics and the stability of ternary complex formation. IF1 is the smallest of the three factors. IF1 enhances the rate of 70S ribosome subunit association and dissociation and the interaction of 30S ribosomal subunit with IF2 and IF3. It stimulates 30S complex formation. In addition, by binding to the A-site of the 30S ribosomal subunit, IF1 may contribute to the fidelity of the selection of the initiation site of the mRNA.


Pssm-ID: 239898  Cd Length: 64  Bit Score: 115.31  E-value: 4.79e-36
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446952627  7 IEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNYIRILAGDRVTVEMSPYDLTRGRITYR 70
Cdd:cd04451   1 IEMEGVVTEALPNAMFRVELENGHEVLAHISGKMRMNYIRILPGDRVKVELSPYDLTKGRIVYR 64
eIF-1a pfam01176
Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation ...
 8-70 1.34e-28

Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.


Pssm-ID: 460099  Cd Length: 62  Bit Score: 96.69  E-value: 1.34e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446952627   8 EVEGKVVDTMPNAMFTVELENGHQILATVSGKIRkNYIRILAGDRVTVEMSPYDLTRGRITYR 70
Cdd:pfam01176  1 EVIGKVVEALGNNLFEVELDNGHTRLAHIPGKMR-NRIWIKRGDYVLVEPSPYDLTKGRIVYR 62
S1 smart00316
Ribosomal protein S1-like RNA-binding domain;
9-72 8.76e-07

Ribosomal protein S1-like RNA-binding domain;


Pssm-ID: 197648 [Multi-domain]  Cd Length: 72  Bit Score: 41.44  E-value: 8.76e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446952627    9 VEGKVVDTMPNaMFTVELENGHQILATVS----GKIRKNYIRILAGDRVTVEMSPYDLTRGRITYRFK 72
Cdd:smart00316  6 VEGTVTEITPG-GAFVDLGNGVEGLIPISelsdKRVKDPEEVLKVGDEVKVKVLSVDEEKGRIILSLK 72
eIF1a smart00652
eukaryotic translation initiation factor 1A;
8-71 4.03e-05

eukaryotic translation initiation factor 1A;


Pssm-ID: 128900  Cd Length: 83  Bit Score: 37.62  E-value: 4.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446952627    8 EVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNyIRILAGDRVTVEMSPYDLTRGRITYRF 71
Cdd:smart00652  6 QEIAQVVKMLGNGRLEVMCADGKERLARIPGKMRKK-VWIRRGDIVLVDPWDFQDVKADIIYKY 68
S1_like cd00164
S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of ...
 9-69 1.74e-03

S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains are members of the Oligonucleotide/oligosaccharide Binding (OB) fold.


Pssm-ID: 238094 [Multi-domain]  Cd Length: 65  Bit Score: 33.12  E-value: 1.74e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446952627  9 VEGKVVDTMPNAMFtVELENGHQILATVS----GKIRKNYIRILAGDRVTVEMSPYDLTRGRITY 69
Cdd:cd00164   1 VTGKVVSITKFGVF-VELEDGVEGLVHISelsdKFVKDPSEVFKVGDEVEVKVLEVDPEKGRISL 64
PRK00098 PRK00098
GTPase RsgA; Reviewed
 22-56 7.09e-03

GTPase RsgA; Reviewed


Pssm-ID: 234631 [Multi-domain]  Cd Length: 298  Bit Score: 32.87  E-value: 7.09e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446952627  22 FTVELENGHQILATVSGKIRKNYIRILAGDRVTVE 56
Cdd:PRK00098  13 YYVESEDGQVYQCRARGKFRKKTNTPAVGDRVEFS 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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