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Conserved domains on  [gi|446953228|ref|WP_001030484|]
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MULTISPECIES: type II toxin-antitoxin system HicB family antitoxin [Enterobacteriaceae]

Protein Classification

type II toxin-antitoxin system HicB family antitoxin( domain architecture ID 10790599)

type II toxin-antitoxin system HicB family antitoxin is the antitoxin component of a type II toxin-antitoxin (TA) system and functions as an mRNA interferase antitoxin preventing effects of the cognate HicA family toxin

Gene Ontology:  GO:0110001
PubMed:  28279904|16895922|30337369
SCOP:  4001747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HicB COG4226
Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];
6-113 2.18e-31

Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];


:

Pssm-ID: 443370 [Multi-domain]  Cd Length: 110  Bit Score: 107.19  E-value: 2.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446953228   6 NIITIKGQPAAVTFEADINAFRGKFLNVNGYCDFVATSIEALYREGESALDEWMADCEEDGIAPfrEEEEQKRLTLRVPH 85
Cdd:COG4226    1 NMMTYKGYTASVEYSPEDGEFVGKVLGIPDLISFEGESVEELEKAFREAVDDYLEDCKELGEEP--EKPYSGKFNVRIPP 78

                         90       100
                 ....*....|....*....|....*...
gi 446953228  86 HIDSRLTIVARQHSISKNQLIVDVLERE 113
Cdd:COG4226   79 ELHRALAIAAAEEGVSLNQWVVEALSEA 106
 
Name Accession Description Interval E-value
HicB COG4226
Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];
6-113 2.18e-31

Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];


Pssm-ID: 443370 [Multi-domain]  Cd Length: 110  Bit Score: 107.19  E-value: 2.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446953228   6 NIITIKGQPAAVTFEADINAFRGKFLNVNGYCDFVATSIEALYREGESALDEWMADCEEDGIAPfrEEEEQKRLTLRVPH 85
Cdd:COG4226    1 NMMTYKGYTASVEYSPEDGEFVGKVLGIPDLISFEGESVEELEKAFREAVDDYLEDCKELGEEP--EKPYSGKFNVRIPP 78

                         90       100
                 ....*....|....*....|....*...
gi 446953228  86 HIDSRLTIVARQHSISKNQLIVDVLERE 113
Cdd:COG4226   79 ELHRALAIAAAEEGVSLNQWVVEALSEA 106
HicB pfam05534
HicB family; This family consists of several bacterial HicB related proteins. The function of ...
 61-110 1.08e-06

HicB family; This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches.


Pssm-ID: 310261  Cd Length: 51  Bit Score: 42.28  E-value: 1.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446953228   61 DCEEDGIAPFREEEeqKRLTLRVPHHIDSRLTIVARQHSISKNQLIVDVL 110
Cdd:pfam05534   4 TCKELGIEPEKPYS--GKFNLRISPELHARLALAAAEQGVSLNQFVEQAL 51
 
Name Accession Description Interval E-value
HicB COG4226
Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];
6-113 2.18e-31

Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];


Pssm-ID: 443370 [Multi-domain]  Cd Length: 110  Bit Score: 107.19  E-value: 2.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446953228   6 NIITIKGQPAAVTFEADINAFRGKFLNVNGYCDFVATSIEALYREGESALDEWMADCEEDGIAPfrEEEEQKRLTLRVPH 85
Cdd:COG4226    1 NMMTYKGYTASVEYSPEDGEFVGKVLGIPDLISFEGESVEELEKAFREAVDDYLEDCKELGEEP--EKPYSGKFNVRIPP 78

                         90       100
                 ....*....|....*....|....*...
gi 446953228  86 HIDSRLTIVARQHSISKNQLIVDVLERE 113
Cdd:COG4226   79 ELHRALAIAAAEEGVSLNQWVVEALSEA 106
HicB pfam05534
HicB family; This family consists of several bacterial HicB related proteins. The function of ...
 61-110 1.08e-06

HicB family; This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches.


Pssm-ID: 310261  Cd Length: 51  Bit Score: 42.28  E-value: 1.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446953228   61 DCEEDGIAPFREEEeqKRLTLRVPHHIDSRLTIVARQHSISKNQLIVDVL 110
Cdd:pfam05534   4 TCKELGIEPEKPYS--GKFNLRISPELHARLALAAAEQGVSLNQFVEQAL 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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