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Conserved domains on  [gi|446963635|ref|WP_001040891|]
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MULTISPECIES: RHS repeat-associated core domain-containing protein [Acinetobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RHS_core super family cl49306
RHS element core protein;
513-1395 1.28e-92

RHS element core protein;


The actual alignment was detected with superfamily member NF041261:

Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 328.89  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  513 AEPLARYEYDTQGNLIKAIDQ-NGHTRTYEYNQFHQLTRYTDR-TGRGQN-IRYESTeakAKAIEEWADDGSFHTKLKWH 589
Cdd:NF041261  316 AAPLVRYTYTEAGELLAVYDRsNTQVRAFTYDAQHPGRMVAHRyAGRPEMcYRYDDT---GRVTEQLNPAGLSYRYQYEQ 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  590 PRlrqVAVYDAYDVPTYYYFDLDGFTYRT---RLADGRESWYSRDGKKRITRQIDFDGRETQQEYNDQDQLV-KIVQPNG 665
Cdd:NF041261  393 DR---ITITDSLNRREVLHTEGEGGLKRVvkkEHADGSVTRSGYDAAGRLTAQTDAAGRRTEYSLNVVSGDItDITTPDG 469

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  666 GIIRFAYNKQGNLVEIKDPEGSIWKREYDENRNVSKEINPLGHITQYKYNNDNQLVE--VIDAKGGVKKIQYNELGQMIS 743
Cdd:NF041261  470 RETKFYYNDGNQLTSVTSPDGLESRREYDEPGRLVSETSRSGETTRYRYDDPHSELPatTTDATGSTKQMTWSRYGQLLA 549

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  744 YTDCSGKSSTWEYDEDGALTAeqtannkvvqyfystkgrdkgqlqsIIYPDGLKEYFEHDEEGRLLKHTDTKGLVTEYKY 823
Cdd:NF041261  550 FTDCSGYQTRYEYDRFGQMTA-------------------------VHREEGISTYRRYDNRGQLTSVKDAQGRETRYEY 604

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  824 NQVGLLEQRI--DANRHSVAY------------------QWDKQGRIQKLINQNQAEYLFGYNPYGYLIREQAFDGEEKH 883
Cdd:NF041261  605 NAAGDLTAVItpDGNRSETQYdawgkavsttqggltrsmEYDAAGRITTLTNENGSHSTFLYDALDRLVQQRGFDGRTQR 684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  884 YSYNENGRLFQIRRPNILTQFDYYADGQIasksfTHLHTGQKQTEQFDYNLNSQLSRAS--NEVSQIDLY--RNALGQLV 959
Cdd:NF041261  685 YHYDLTGKLTQSEDEGLVTLWHYDESDRI-----THRTVNGEPAEQWQYDEHGWLTDIShlSEGHRVAVHygYDDKGRLT 759

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  960 REHQHYKIPELKPL--TAVLHYEYDELGnLIKTIRPDG-HTLNHLVYGSGHIYAIGLNNQEVVSFQRDDLHRETTRLLA- 1035
Cdd:NF041261  760 GERQTVENPETGELlwQHETGHAYNEQG-LANRVTPDSlPPVEWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGg 838

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1036 ----NGLMQTKQYNDVGLLSSQFIQPEQETQDylqyqahrkYHYDKNYLLSQVEDSRLGKlNYQYDPIGRLiaaQSLHKT 1111
Cdd:NF041261  839 agsnAAYELTTAYTPAGQLQSQHLNSLVYDRD---------YTWNDNGDLVRISGPRQTR-EYGYSATGRL---TGVHTT 905

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1112 ES-------FNFDPAGN-LIDSEsvLSPAQI----KNNLIKSYKGKHYQYDVQGNVTE---IIQAG-------KNLKLTW 1169
Cdd:NF041261  906 AAnldiripYATDPAGNrLPDPE--LHPDSTltawPDNRIAEDAHYVYRYDEYGRLTEktdRIPEGvirtddeRTHHYHY 983

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1170 DNQNRLI---RSDNNGLVTE--YGYDVFGRRLYKKTAK---------------ELTLFGWDGDLMiwesfKSAQTNYTK- 1228
Cdd:NF041261  984 DSQHRLVfytRIQHGEPLVEsrYLYDPLGRRMAKRVWRrerdltgwmslsrkpEVTWYGWDGDRL-----TTVQTDTTRi 1058

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1229 HYIYEPDSFVPLLQA----GYKDFIQ---LIETPDyQEYQTKPYSIYKDPVWNRNLGK---------------------- 1279
Cdd:NF041261 1059 QTVYQPGSFTPLIRVetenGERAKAQrrsLAETLQ-QEGSENGHGVVFPAELVRMLDRleeeiradrvseesrawlaqcg 1137

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1280 ------------ERTALEQFTFYHCDQVGTPQTMTNIRGECVWEILQDTWGavsqiKALNQDNPFE-QNNLRFQGQYYDR 1346
Cdd:NF041261 1138 ltveqmarqvepEYTPARKLHLYHCDHRGLPLALISEEGNTAWQGEYDEWG-----NLLNEENPHHlQQPYRLPGQQYDE 1212

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*....
gi 446963635 1347 ETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVSDPNQWIDPKGL 1395
Cdd:NF041261 1213 ESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
FIX_RhsA-like cd20743
Found in type sIX effector (FIX) domain of unknown function co-occurring with RhsA domains ...
 31-122 2.25e-21

Found in type sIX effector (FIX) domain of unknown function co-occurring with RhsA domains with RHS repeats; The Found in type sIX effector (FIX) domain is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. In this subfamily, members contain a FIX domain that co-occurs with C-terminal RhsA-like domain, which contains extended repeat regions and RHS repeats. Some in this family have additional C-terminal domains such as AAH, a predicted nuclease domain with conserved AHH motif that is found in bacterial polymorphic toxin systems and functions as a toxin module.


:

Pssm-ID: 410941  Cd Length: 92  Bit Score: 90.00  E-value: 2.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635   31 ADLQMIASQVQLYLQVCGNTTLEQIKSKA-NITTVANIFALTGSVLDLMLYAtDKKTGDAAVQRGALLAANLIGLFSEPN 109
Cdd:cd20743     1 VDAGAKAFDKWLRSISDGYVTLDRLKTVAgMVPVVGNIMALVDVVLDIVALI-EKPGNNADVLDWVNLGIDLIGIIPAPP 79

                          90
                  ....*....|...
gi 446963635  110 NEAHARMALRPMF 122
Cdd:cd20743    80 ATAPARMSLRPAL 92
DUF6531 super family cl45520
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.
 333-402 7.95e-03

Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.


The actual alignment was detected with superfamily member pfam20148:

Pssm-ID: 466309 [Multi-domain]  Cd Length: 74  Bit Score: 36.74  E-value: 7.95e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446963635   333 GKSISYSIGAERVQHADFYLP-KIGFSFIRQYNSQMDEfdQSMVGARWMMPFSNMIQ-QNAQGYLFIDSKGR 402
Cdd:pfam20148    1 GDPVNVATGNKVLEETDFSLPgPLPLVWTRTYNSSSER--DGPLGPGWSHPYDQRLElEGDGGVVYIDADGR 70
 
Name Accession Description Interval E-value
RHS_core NF041261
RHS element core protein;
513-1395 1.28e-92

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 328.89  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  513 AEPLARYEYDTQGNLIKAIDQ-NGHTRTYEYNQFHQLTRYTDR-TGRGQN-IRYESTeakAKAIEEWADDGSFHTKLKWH 589
Cdd:NF041261  316 AAPLVRYTYTEAGELLAVYDRsNTQVRAFTYDAQHPGRMVAHRyAGRPEMcYRYDDT---GRVTEQLNPAGLSYRYQYEQ 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  590 PRlrqVAVYDAYDVPTYYYFDLDGFTYRT---RLADGRESWYSRDGKKRITRQIDFDGRETQQEYNDQDQLV-KIVQPNG 665
Cdd:NF041261  393 DR---ITITDSLNRREVLHTEGEGGLKRVvkkEHADGSVTRSGYDAAGRLTAQTDAAGRRTEYSLNVVSGDItDITTPDG 469

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  666 GIIRFAYNKQGNLVEIKDPEGSIWKREYDENRNVSKEINPLGHITQYKYNNDNQLVE--VIDAKGGVKKIQYNELGQMIS 743
Cdd:NF041261  470 RETKFYYNDGNQLTSVTSPDGLESRREYDEPGRLVSETSRSGETTRYRYDDPHSELPatTTDATGSTKQMTWSRYGQLLA 549

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  744 YTDCSGKSSTWEYDEDGALTAeqtannkvvqyfystkgrdkgqlqsIIYPDGLKEYFEHDEEGRLLKHTDTKGLVTEYKY 823
Cdd:NF041261  550 FTDCSGYQTRYEYDRFGQMTA-------------------------VHREEGISTYRRYDNRGQLTSVKDAQGRETRYEY 604

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  824 NQVGLLEQRI--DANRHSVAY------------------QWDKQGRIQKLINQNQAEYLFGYNPYGYLIREQAFDGEEKH 883
Cdd:NF041261  605 NAAGDLTAVItpDGNRSETQYdawgkavsttqggltrsmEYDAAGRITTLTNENGSHSTFLYDALDRLVQQRGFDGRTQR 684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  884 YSYNENGRLFQIRRPNILTQFDYYADGQIasksfTHLHTGQKQTEQFDYNLNSQLSRAS--NEVSQIDLY--RNALGQLV 959
Cdd:NF041261  685 YHYDLTGKLTQSEDEGLVTLWHYDESDRI-----THRTVNGEPAEQWQYDEHGWLTDIShlSEGHRVAVHygYDDKGRLT 759

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  960 REHQHYKIPELKPL--TAVLHYEYDELGnLIKTIRPDG-HTLNHLVYGSGHIYAIGLNNQEVVSFQRDDLHRETTRLLA- 1035
Cdd:NF041261  760 GERQTVENPETGELlwQHETGHAYNEQG-LANRVTPDSlPPVEWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGg 838

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1036 ----NGLMQTKQYNDVGLLSSQFIQPEQETQDylqyqahrkYHYDKNYLLSQVEDSRLGKlNYQYDPIGRLiaaQSLHKT 1111
Cdd:NF041261  839 agsnAAYELTTAYTPAGQLQSQHLNSLVYDRD---------YTWNDNGDLVRISGPRQTR-EYGYSATGRL---TGVHTT 905

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1112 ES-------FNFDPAGN-LIDSEsvLSPAQI----KNNLIKSYKGKHYQYDVQGNVTE---IIQAG-------KNLKLTW 1169
Cdd:NF041261  906 AAnldiripYATDPAGNrLPDPE--LHPDSTltawPDNRIAEDAHYVYRYDEYGRLTEktdRIPEGvirtddeRTHHYHY 983

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1170 DNQNRLI---RSDNNGLVTE--YGYDVFGRRLYKKTAK---------------ELTLFGWDGDLMiwesfKSAQTNYTK- 1228
Cdd:NF041261  984 DSQHRLVfytRIQHGEPLVEsrYLYDPLGRRMAKRVWRrerdltgwmslsrkpEVTWYGWDGDRL-----TTVQTDTTRi 1058

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1229 HYIYEPDSFVPLLQA----GYKDFIQ---LIETPDyQEYQTKPYSIYKDPVWNRNLGK---------------------- 1279
Cdd:NF041261 1059 QTVYQPGSFTPLIRVetenGERAKAQrrsLAETLQ-QEGSENGHGVVFPAELVRMLDRleeeiradrvseesrawlaqcg 1137

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1280 ------------ERTALEQFTFYHCDQVGTPQTMTNIRGECVWEILQDTWGavsqiKALNQDNPFE-QNNLRFQGQYYDR 1346
Cdd:NF041261 1138 ltveqmarqvepEYTPARKLHLYHCDHRGLPLALISEEGNTAWQGEYDEWG-----NLLNEENPHHlQQPYRLPGQQYDE 1212

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*....
gi 446963635 1347 ETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVSDPNQWIDPKGL 1395
Cdd:NF041261 1213 ESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 752-1418 3.50e-41

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 166.08  E-value: 3.50e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  752 STWEYDEDGALTAEQTANNKVVQYFYSTKGRDKGQLQSIIYPDGLKEYFEHDEEGRLLKHTDTKGLVTEYKYNQVGLLEQ 831
Cdd:COG3209   536 TLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTR 615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  832 RIDANRHSVAYQWDKQGRIQKLINQNQAEYLFGYNPYGYLIREQAFDGEEKHYSYNENGRLFQIRRPNILTQFDYYADGQ 911
Cdd:COG3209   616 AGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATT 695

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  912 IASKSFTHLHTGQKQTEQFDYNLNSQLSRASNEVSQIDLYRNALGQLVREHQHYKIPELkplTAVLHYEYDELGNLIKTI 991
Cdd:COG3209   696 GATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTT---AGALTYTYDALGRLTSET 772

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  992 RPDGHTLNHLVygsghiyaiglnnqevVSFQRDDLHRETTRLLANGLMQTKQYNDVGLLSSQfIQPEQETQDYLQyqaHR 1071
Cdd:COG3209   773 TPGGVTQGTYT----------------TRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSV-ITVGSGGGTDLQ---DR 832

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1072 KYHYDKNYLLSQVEDSRLG---KLNYQYDPIGRLIAAQSLHKTESfnfdpagnlidsesvlspaqiknnliksykgkhYQ 1148
Cdd:COG3209   833 TYTYDAAGNITSITDALRAgtlTQTYTYDALGRLTSATDPGTTES---------------------------------YT 879

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1149 YDVQGNVTEIIQAGkNLKLTWDNQNRLIR-SDNNGLVTEYGYDVFGrrlykktakeltlfgwdgdlmiwesfksaqtnyt 1227
Cdd:COG3209   880 YDANGNLTSRTDGG-TTTYTYDALGRLVSvTKPDGTTTTYTYDALG---------------------------------- 924

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1228 khyiyepdsfvpllqagykdfiqlietpdyqeyqtkpysiykdpvwnrnlgkertaleqftfyHCDQVGTPQTMTNIRGE 1307
Cdd:COG3209   925 ---------------------------------------------------------------HTDHLGSVRALTDASGQ 941

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1308 CVWEILQDTWGAVSQIKALNQDNPFeqnnlRFQGQYYDRETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVS-DP 1386
Cdd:COG3209   942 VVWRYDYDPFGNLLAETSGAAANPL-----RFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNLYAYVGnNP 1016

                         650       660       670
                  ....*....|....*....|....*....|..
gi 446963635 1387 NQWIDPKGLNSFNYGEMFGIPASAQSGLAYQG 1418
Cdd:COG3209  1017 VNYVDPLGLAALLGTTGLGGGAGVGAGAAGGG 1048
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 1315-1395 6.00e-26

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 102.58  E-value: 6.00e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  1315 DTWGAVSQIKALNQdnpfeqNNLRFQGQYYDRETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVS-DPNQWIDPK 1393
Cdd:TIGR03696    2 DPYGEVLSESGAAP------NPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYVGnNPVNWVDPL 75


                   ..
gi 446963635  1394 GL 1395
Cdd:TIGR03696   76 GL 77
FIX_RhsA-like cd20743
Found in type sIX effector (FIX) domain of unknown function co-occurring with RhsA domains ...
 31-122 2.25e-21

Found in type sIX effector (FIX) domain of unknown function co-occurring with RhsA domains with RHS repeats; The Found in type sIX effector (FIX) domain is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. In this subfamily, members contain a FIX domain that co-occurs with C-terminal RhsA-like domain, which contains extended repeat regions and RHS repeats. Some in this family have additional C-terminal domains such as AAH, a predicted nuclease domain with conserved AHH motif that is found in bacterial polymorphic toxin systems and functions as a toxin module.


Pssm-ID: 410941  Cd Length: 92  Bit Score: 90.00  E-value: 2.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635   31 ADLQMIASQVQLYLQVCGNTTLEQIKSKA-NITTVANIFALTGSVLDLMLYAtDKKTGDAAVQRGALLAANLIGLFSEPN 109
Cdd:cd20743     1 VDAGAKAFDKWLRSISDGYVTLDRLKTVAgMVPVVGNIMALVDVVLDIVALI-EKPGNNADVLDWVNLGIDLIGIIPAPP 79

                          90
                  ....*....|...
gi 446963635  110 NEAHARMALRPMF 122
Cdd:cd20743    80 ATAPARMSLRPAL 92
RHS pfam03527
RHS protein;
1289-1322 3.63e-08

RHS protein;


Pssm-ID: 427349 [Multi-domain]  Cd Length: 38  Bit Score: 50.77  E-value: 3.63e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 446963635  1289 FYHCDQVGTPQTMTNIRGECVWEILQDTWGAVSQ 1322
Cdd:pfam03527    3 YYHTDHLGTPEELTDEAGEIVWSAEYDAWGNVTE 36
Bacuni_01323_like cd12871
Uncharacterized protein conserved in Bacteroidetes; A well-conserved family of 16-stranded ...
 650-860 9.63e-04

Uncharacterized protein conserved in Bacteroidetes; A well-conserved family of 16-stranded beta barrels resembling outer membrane porins. The interior of the barrels is mostly occupied by an insert with partially helical structure.


Pssm-ID: 214015 [Multi-domain]  Cd Length: 231  Bit Score: 42.41  E-value: 9.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  650 EYNDQDQLVKIVQPNGGIIRFAYNKQG-----NLVEIKDpEGSIWKREY--DENRNVSKEI-----NPLGHITQYKYNND 717
Cdd:cd12871    22 EYDADGRLTSITTTQEGEAEEITYTTTityepNVITVTD-DGGKTVSTYtlNEKGYVTSCTeteygKGQLRTYTFTYNAD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  718 NQLVEVIDAKGGVK---KIQYNElGQMISYTDCSGKSS-TWEYDEDGALTAEQTANNKVVQYFYSTKGRDKGQLQSIIYP 793
Cdd:cd12871   101 GQLTKIVESIGTEYstiTITWNN-GDIVSISTKSNTEEnESKITYTSDKVYNPIVNKGCLMLFGLTLGYDLSDLFYAYYA 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446963635  794 DGLKEYFEHdeegrLLKHTDTKGLVTEYKYNqvglleqridanrhsvaYQWDKQGRIQKLINQNQAE 860
Cdd:cd12871   180 GLLGKATKH-----LPESIIPKGNEETTTYT-----------------YTFDKNGYPTSIIVTYSGD 224
DUF6531 pfam20148
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.
 333-402 7.95e-03

Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.


Pssm-ID: 466309 [Multi-domain]  Cd Length: 74  Bit Score: 36.74  E-value: 7.95e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446963635   333 GKSISYSIGAERVQHADFYLP-KIGFSFIRQYNSQMDEfdQSMVGARWMMPFSNMIQ-QNAQGYLFIDSKGR 402
Cdd:pfam20148    1 GDPVNVATGNKVLEETDFSLPgPLPLVWTRTYNSSSER--DGPLGPGWSHPYDQRLElEGDGGVVYIDADGR 70
 
Name Accession Description Interval E-value
RHS_core NF041261
RHS element core protein;
513-1395 1.28e-92

RHS element core protein;


Pssm-ID: 469161 [Multi-domain]  Cd Length: 1261  Bit Score: 328.89  E-value: 1.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  513 AEPLARYEYDTQGNLIKAIDQ-NGHTRTYEYNQFHQLTRYTDR-TGRGQN-IRYESTeakAKAIEEWADDGSFHTKLKWH 589
Cdd:NF041261  316 AAPLVRYTYTEAGELLAVYDRsNTQVRAFTYDAQHPGRMVAHRyAGRPEMcYRYDDT---GRVTEQLNPAGLSYRYQYEQ 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  590 PRlrqVAVYDAYDVPTYYYFDLDGFTYRT---RLADGRESWYSRDGKKRITRQIDFDGRETQQEYNDQDQLV-KIVQPNG 665
Cdd:NF041261  393 DR---ITITDSLNRREVLHTEGEGGLKRVvkkEHADGSVTRSGYDAAGRLTAQTDAAGRRTEYSLNVVSGDItDITTPDG 469

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  666 GIIRFAYNKQGNLVEIKDPEGSIWKREYDENRNVSKEINPLGHITQYKYNNDNQLVE--VIDAKGGVKKIQYNELGQMIS 743
Cdd:NF041261  470 RETKFYYNDGNQLTSVTSPDGLESRREYDEPGRLVSETSRSGETTRYRYDDPHSELPatTTDATGSTKQMTWSRYGQLLA 549

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  744 YTDCSGKSSTWEYDEDGALTAeqtannkvvqyfystkgrdkgqlqsIIYPDGLKEYFEHDEEGRLLKHTDTKGLVTEYKY 823
Cdd:NF041261  550 FTDCSGYQTRYEYDRFGQMTA-------------------------VHREEGISTYRRYDNRGQLTSVKDAQGRETRYEY 604

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  824 NQVGLLEQRI--DANRHSVAY------------------QWDKQGRIQKLINQNQAEYLFGYNPYGYLIREQAFDGEEKH 883
Cdd:NF041261  605 NAAGDLTAVItpDGNRSETQYdawgkavsttqggltrsmEYDAAGRITTLTNENGSHSTFLYDALDRLVQQRGFDGRTQR 684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  884 YSYNENGRLFQIRRPNILTQFDYYADGQIasksfTHLHTGQKQTEQFDYNLNSQLSRAS--NEVSQIDLY--RNALGQLV 959
Cdd:NF041261  685 YHYDLTGKLTQSEDEGLVTLWHYDESDRI-----THRTVNGEPAEQWQYDEHGWLTDIShlSEGHRVAVHygYDDKGRLT 759

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  960 REHQHYKIPELKPL--TAVLHYEYDELGnLIKTIRPDG-HTLNHLVYGSGHIYAIGLNNQEVVSFQRDDLHRETTRLLA- 1035
Cdd:NF041261  760 GERQTVENPETGELlwQHETGHAYNEQG-LANRVTPDSlPPVEWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGg 838

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1036 ----NGLMQTKQYNDVGLLSSQFIQPEQETQDylqyqahrkYHYDKNYLLSQVEDSRLGKlNYQYDPIGRLiaaQSLHKT 1111
Cdd:NF041261  839 agsnAAYELTTAYTPAGQLQSQHLNSLVYDRD---------YTWNDNGDLVRISGPRQTR-EYGYSATGRL---TGVHTT 905

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1112 ES-------FNFDPAGN-LIDSEsvLSPAQI----KNNLIKSYKGKHYQYDVQGNVTE---IIQAG-------KNLKLTW 1169
Cdd:NF041261  906 AAnldiripYATDPAGNrLPDPE--LHPDSTltawPDNRIAEDAHYVYRYDEYGRLTEktdRIPEGvirtddeRTHHYHY 983

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1170 DNQNRLI---RSDNNGLVTE--YGYDVFGRRLYKKTAK---------------ELTLFGWDGDLMiwesfKSAQTNYTK- 1228
Cdd:NF041261  984 DSQHRLVfytRIQHGEPLVEsrYLYDPLGRRMAKRVWRrerdltgwmslsrkpEVTWYGWDGDRL-----TTVQTDTTRi 1058

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1229 HYIYEPDSFVPLLQA----GYKDFIQ---LIETPDyQEYQTKPYSIYKDPVWNRNLGK---------------------- 1279
Cdd:NF041261 1059 QTVYQPGSFTPLIRVetenGERAKAQrrsLAETLQ-QEGSENGHGVVFPAELVRMLDRleeeiradrvseesrawlaqcg 1137

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1280 ------------ERTALEQFTFYHCDQVGTPQTMTNIRGECVWEILQDTWGavsqiKALNQDNPFE-QNNLRFQGQYYDR 1346
Cdd:NF041261 1138 ltveqmarqvepEYTPARKLHLYHCDHRGLPLALISEEGNTAWQGEYDEWG-----NLLNEENPHHlQQPYRLPGQQYDE 1212

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*....
gi 446963635 1347 ETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVSDPNQWIDPKGL 1395
Cdd:NF041261 1213 ESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 752-1418 3.50e-41

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 166.08  E-value: 3.50e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  752 STWEYDEDGALTAEQTANNKVVQYFYSTKGRDKGQLQSIIYPDGLKEYFEHDEEGRLLKHTDTKGLVTEYKYNQVGLLEQ 831
Cdd:COG3209   536 TLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTR 615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  832 RIDANRHSVAYQWDKQGRIQKLINQNQAEYLFGYNPYGYLIREQAFDGEEKHYSYNENGRLFQIRRPNILTQFDYYADGQ 911
Cdd:COG3209   616 AGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATT 695

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  912 IASKSFTHLHTGQKQTEQFDYNLNSQLSRASNEVSQIDLYRNALGQLVREHQHYKIPELkplTAVLHYEYDELGNLIKTI 991
Cdd:COG3209   696 GATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTT---AGALTYTYDALGRLTSET 772

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  992 RPDGHTLNHLVygsghiyaiglnnqevVSFQRDDLHRETTRLLANGLMQTKQYNDVGLLSSQfIQPEQETQDYLQyqaHR 1071
Cdd:COG3209   773 TPGGVTQGTYT----------------TRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSV-ITVGSGGGTDLQ---DR 832

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1072 KYHYDKNYLLSQVEDSRLG---KLNYQYDPIGRLIAAQSLHKTESfnfdpagnlidsesvlspaqiknnliksykgkhYQ 1148
Cdd:COG3209   833 TYTYDAAGNITSITDALRAgtlTQTYTYDALGRLTSATDPGTTES---------------------------------YT 879

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1149 YDVQGNVTEIIQAGkNLKLTWDNQNRLIR-SDNNGLVTEYGYDVFGrrlykktakeltlfgwdgdlmiwesfksaqtnyt 1227
Cdd:COG3209   880 YDANGNLTSRTDGG-TTTYTYDALGRLVSvTKPDGTTTTYTYDALG---------------------------------- 924

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1228 khyiyepdsfvpllqagykdfiqlietpdyqeyqtkpysiykdpvwnrnlgkertaleqftfyHCDQVGTPQTMTNIRGE 1307
Cdd:COG3209   925 ---------------------------------------------------------------HTDHLGSVRALTDASGQ 941

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635 1308 CVWEILQDTWGAVSQIKALNQDNPFeqnnlRFQGQYYDRETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVS-DP 1386
Cdd:COG3209   942 VVWRYDYDPFGNLLAETSGAAANPL-----RFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNLYAYVGnNP 1016

                         650       660       670
                  ....*....|....*....|....*....|..
gi 446963635 1387 NQWIDPKGLNSFNYGEMFGIPASAQSGLAYQG 1418
Cdd:COG3209  1017 VNYVDPLGLAALLGTTGLGGGAGVGAGAAGGG 1048
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
 1315-1395 6.00e-26

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 102.58  E-value: 6.00e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  1315 DTWGAVSQIKALNQdnpfeqNNLRFQGQYYDRETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVS-DPNQWIDPK 1393
Cdd:TIGR03696    2 DPYGEVLSESGAAP------NPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYVGnNPVNWVDPL 75


                   ..
gi 446963635  1394 GL 1395
Cdd:TIGR03696   76 GL 77
FIX_RhsA-like cd20743
Found in type sIX effector (FIX) domain of unknown function co-occurring with RhsA domains ...
 31-122 2.25e-21

Found in type sIX effector (FIX) domain of unknown function co-occurring with RhsA domains with RHS repeats; The Found in type sIX effector (FIX) domain is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. In this subfamily, members contain a FIX domain that co-occurs with C-terminal RhsA-like domain, which contains extended repeat regions and RHS repeats. Some in this family have additional C-terminal domains such as AAH, a predicted nuclease domain with conserved AHH motif that is found in bacterial polymorphic toxin systems and functions as a toxin module.


Pssm-ID: 410941  Cd Length: 92  Bit Score: 90.00  E-value: 2.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635   31 ADLQMIASQVQLYLQVCGNTTLEQIKSKA-NITTVANIFALTGSVLDLMLYAtDKKTGDAAVQRGALLAANLIGLFSEPN 109
Cdd:cd20743     1 VDAGAKAFDKWLRSISDGYVTLDRLKTVAgMVPVVGNIMALVDVVLDIVALI-EKPGNNADVLDWVNLGIDLIGIIPAPP 79

                          90
                  ....*....|...
gi 446963635  110 NEAHARMALRPMF 122
Cdd:cd20743    80 ATAPARMSLRPAL 92
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 518-777 1.56e-15

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 82.50  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  518 RYEYDTQGNLIKAIDQNGHTRTYEYNQFHQLTRYTDRTGRGQNIRYESTEAKAKAIEEWADDGSFHTKLKWHPRLRQVAV 597
Cdd:COG3209   645 TGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTT 724

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  598 YDAYDVPTYYYFDLDGFTYRTRLADGRESW-----YSRDGKKRITRQIDFDG-----RETQQEYNDQDQLVKIVQPNGGI 667
Cdd:COG3209   725 GGGGGTTTDGTGTGGTTGTLTTTSTTTTTTagaltYTYDALGRLTSETTPGGvtqgtYTTRYTYDALGRLTSVTYPDGET 804

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  668 IRFAYNKQGNLVEI----KDPEGSIWKRE--YDENRNVSKEINPLGH---ITQYKYNNDNQLVEVIDAkGGVKKIQYNEL 738
Cdd:COG3209   805 VTYTYDALGRLTSVitvgSGGGTDLQDRTytYDAAGNITSITDALRAgtlTQTYTYDALGRLTSATDP-GTTESYTYDAN 883

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 446963635  739 GQMISYTDcsGKSSTWEYDEDGALTAEQTANNKVVQYFY 777
Cdd:COG3209   884 GNLTSRTD--GGTTTYTYDALGRLVSVTKPDGTTTTYTY 920
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 518-910 3.13e-15

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 81.73  E-value: 3.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  518 RYEYDTQGNLIKAIDQNGHTRTYEYNQFHQLTRYTDRTGRGQNIRYESTEAKAKAIEEWADDGSFHTKLKWHPRLRQVAV 597
Cdd:COG3209   538 SATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAG 617

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  598 YDAYDVPTYYYFDLDGFTYRTRLADGRESWYSRDGKKRITRQIDFDGRETQQEYNDQDQLVKIVQPNGGIIRFAYNKQGN 677
Cdd:COG3209   618 LTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGA 697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  678 L-VEIKDPEGSIWKREYDENRNVSKEINPLGHITQYKYNNDNQLVEVIDAKGGVKKI------QYNELGQMISYTDCSGk 750
Cdd:COG3209   698 TtGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTagaltyTYDALGRLTSETTPGG- 776

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  751 sstweydedgaltaeQTANNKVVQYFYSTKGRdkgqLQSIIYPDGLKEYFEHDEEGRL------LKHTDTKGLVTEYKYN 824
Cdd:COG3209   777 ---------------VTQGTYTTRYTYDALGR----LTSVTYPDGETVTYTYDALGRLtsvitvGSGGGTDLQDRTYTYD 837

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  825 QVGLLEQRIDANRHSV---AYQWDKQGRIQKLINQNQAEyLFGYNPYGYLIREQafDGEEKHYSYNENGRLFQIRRPN-I 900
Cdd:COG3209   838 AAGNITSITDALRAGTltqTYTYDALGRLTSATDPGTTE-SYTYDANGNLTSRT--DGGTTTYTYDALGRLVSVTKPDgT 914

                         410
                  ....*....|
gi 446963635  901 LTQFDYYADG 910
Cdd:COG3209   915 TTTYTYDALG 924
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 518-694 4.97e-10

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 64.78  E-value: 4.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  518 RYEYDTQGNLIKAIDQNGHTRTYEYNQFHQLTR----YTDRTGRGQNIRYESTEA-KAKAIEEWADDGSFHTKLKWHPRL 592
Cdd:COG3209   785 RYTYDALGRLTSVTYPDGETVTYTYDALGRLTSvitvGSGGGTDLQDRTYTYDAAgNITSITDALRAGTLTQTYTYDALG 864

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  593 RQVAVYDAYDVPTYYYfdlDGFTYRTRLADGRESWYSrdgkkritrqidfdgretqqeYNDQDQLVKIVQPNGGIIRFAY 672
Cdd:COG3209   865 RLTSATDPGTTESYTY---DANGNLTSRTDGGTTTYT---------------------YDALGRLVSVTKPDGTTTTYTY 920

                         170       180
                  ....*....|....*....|....*....
gi 446963635  673 ------NKQGNLVEIKDPEGSI-WKREYD 694
Cdd:COG3209   921 dalghtDHLGSVRALTDASGQVvWRYDYD 949
RHS pfam03527
RHS protein;
1289-1322 3.63e-08

RHS protein;


Pssm-ID: 427349 [Multi-domain]  Cd Length: 38  Bit Score: 50.77  E-value: 3.63e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 446963635  1289 FYHCDQVGTPQTMTNIRGECVWEILQDTWGAVSQ 1322
Cdd:pfam03527    3 YYHTDHLGTPEELTDEAGEIVWSAEYDAWGNVTE 36
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
 510-760 5.24e-08

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 57.84  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  510 DDKAEPLARYEYDTQGNLIKAIDQNGHTRTYEYNQFHQLTRYTDRTGrgqniryesteakakaieewaddgsfhtklkwh 589
Cdd:COG3209   730 TTTDGTGTGGTTGTLTTTSTTTTTTAGALTYTYDALGRLTSETTPGG--------------------------------- 776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  590 prlrqvavydaydvptyyyfdLDGFTYRTRladgreswYSRDGKKRITRQIDFDGRETQQEYNDQDQLVKIVQPNGGI-- 667
Cdd:COG3209   777 ---------------------VTQGTYTTR--------YTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGGgt 827

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  668 ----IRFAYNKQGNLVEIKDPEGSIWKRE---YDENRNVSKEINPlGHITQYKYNNDNQLVEviDAKGGVKKIQYNELGQ 740
Cdd:COG3209   828 dlqdRTYTYDAAGNITSITDALRAGTLTQtytYDALGRLTSATDP-GTTESYTYDANGNLTS--RTDGGTTTYTYDALGR 904

                         250       260
                  ....*....|....*....|
gi 446963635  741 MISYTDCSGKSSTWEYDEDG 760
Cdd:COG3209   905 LVSVTKPDGTTTTYTYDALG 924
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
 521-557 3.08e-06

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 45.28  E-value: 3.08e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 446963635   521 YDTQGNLIKAIDQNGHTRTYEYNQFHQLTRYTDRTGR 557
Cdd:pfam05593    1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
 651-687 1.06e-05

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 43.74  E-value: 1.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 446963635   651 YNDQDQLVKIVQPNGGIIRFAYNKQGNLVEIKDPEGS 687
Cdd:pfam05593    1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
 651-690 1.89e-05

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 42.96  E-value: 1.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 446963635   651 YNDQDQLVKIVQPNGGIIRFAYNKQGNLVEIKDPEGSIWK 690
Cdd:TIGR01643    1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTR 40
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
 521-557 3.06e-05

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 42.58  E-value: 3.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 446963635   521 YDTQGNLIKAIDQNGHTRTYEYNQFHQLTRYTDRTGR 557
Cdd:TIGR01643    1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGG 37
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
 735-769 1.24e-04

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 40.66  E-value: 1.24e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 446963635   735 YNELGQMISYTDCSGKSSTWEYDEDGALTAEQTAN 769
Cdd:pfam05593    1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPD 35
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
 672-707 1.83e-04

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 40.27  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 446963635   672 YNKQGNLVEIKDPEGSIWKREYDENRNVSKEINPLG 707
Cdd:pfam05593    1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
 672-712 3.06e-04

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 39.88  E-value: 3.06e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 446963635   672 YNKQGNLVEIKDPEGSIWKREYDENRNVSKEINPLGHITQY 712
Cdd:TIGR01643    1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
Bacuni_01323_like cd12871
Uncharacterized protein conserved in Bacteroidetes; A well-conserved family of 16-stranded ...
 650-860 9.63e-04

Uncharacterized protein conserved in Bacteroidetes; A well-conserved family of 16-stranded beta barrels resembling outer membrane porins. The interior of the barrels is mostly occupied by an insert with partially helical structure.


Pssm-ID: 214015 [Multi-domain]  Cd Length: 231  Bit Score: 42.41  E-value: 9.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  650 EYNDQDQLVKIVQPNGGIIRFAYNKQG-----NLVEIKDpEGSIWKREY--DENRNVSKEI-----NPLGHITQYKYNND 717
Cdd:cd12871    22 EYDADGRLTSITTTQEGEAEEITYTTTityepNVITVTD-DGGKTVSTYtlNEKGYVTSCTeteygKGQLRTYTFTYNAD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446963635  718 NQLVEVIDAKGGVK---KIQYNElGQMISYTDCSGKSS-TWEYDEDGALTAEQTANNKVVQYFYSTKGRDKGQLQSIIYP 793
Cdd:cd12871   101 GQLTKIVESIGTEYstiTITWNN-GDIVSISTKSNTEEnESKITYTSDKVYNPIVNKGCLMLFGLTLGYDLSDLFYAYYA 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446963635  794 DGLKEYFEHdeegrLLKHTDTKGLVTEYKYNqvglleqridanrhsvaYQWDKQGRIQKLINQNQAE 860
Cdd:cd12871   180 GLLGKATKH-----LPESIIPKGNEETTTYT-----------------YTFDKNGYPTSIIVTYSGD 224
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
 735-775 2.28e-03

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 37.18  E-value: 2.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 446963635   735 YNELGQMISYTDCSGKSSTWEYDEDGALTAEQTANNKVVQY 775
Cdd:TIGR01643    1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
 802-843 4.19e-03

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 36.41  E-value: 4.19e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 446963635   802 HDEEGRLLKHTDTKGLVTEYKYNQVGLLEQRIDANRHSVAYQ 843
Cdd:TIGR01643    1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
 802-836 4.71e-03

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 36.42  E-value: 4.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 446963635   802 HDEEGRLLKHTDTKGLVTEYKYNQVGLLEQRIDAN 836
Cdd:pfam05593    1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPD 35
DUF6531 pfam20148
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.
 333-402 7.95e-03

Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.


Pssm-ID: 466309 [Multi-domain]  Cd Length: 74  Bit Score: 36.74  E-value: 7.95e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446963635   333 GKSISYSIGAERVQHADFYLP-KIGFSFIRQYNSQMDEfdQSMVGARWMMPFSNMIQ-QNAQGYLFIDSKGR 402
Cdd:pfam20148    1 GDPVNVATGNKVLEETDFSLPgPLPLVWTRTYNSSSER--DGPLGPGWSHPYDQRLElEGDGGVVYIDADGR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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