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Conserved domains on  [gi|446993257|ref|WP_001070513|]
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MULTISPECIES: hypothetical protein [Bacteria]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11457519)

helix-turn-helix (HTH) transcriptional regulator containing a DNA-binding HTH domain, may act as a transcriptional activator or as a transcriptional repressor

Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  15808743|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 1-82 1.95e-07

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


:

Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 44.90  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446993257   1 MNQAALITIANELNHDQMRVLMALLaeldyENYIQVAQIDIAEALTMQKTNVSRAVKNLIDFGIIlEGPKIGRSKTYRLN 80
Cdd:COG2512    1 MLVVAALLLYPELLEDERRVLELLR-----ENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLI-EKERVGRENVVELP 74


                 ..
gi 446993257  81 PQ 82
Cdd:COG2512   75 ED 76
 
Name Accession Description Interval E-value
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 1-82 1.95e-07

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 44.90  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446993257   1 MNQAALITIANELNHDQMRVLMALLaeldyENYIQVAQIDIAEALTMQKTNVSRAVKNLIDFGIIlEGPKIGRSKTYRLN 80
Cdd:COG2512    1 MLVVAALLLYPELLEDERRVLELLR-----ENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLI-EKERVGRENVVELP 74


                 ..
gi 446993257  81 PQ 82
Cdd:COG2512   75 ED 76
HTH_36 pfam13730
Helix-turn-helix domain;
11-65 6.49e-05

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 37.47  E-value: 6.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446993257   11 NELNHDQMRVLMALLAELDYENYIQVAQIDIAEALTMQKTNVSRAVKNLIDFGII 65
Cdd:pfam13730   1 LRLSPTAKLLLLILASYANKDGGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
 
Name Accession Description Interval E-value
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 1-82 1.95e-07

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 44.90  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446993257   1 MNQAALITIANELNHDQMRVLMALLaeldyENYIQVAQIDIAEALTMQKTNVSRAVKNLIDFGIIlEGPKIGRSKTYRLN 80
Cdd:COG2512    1 MLVVAALLLYPELLEDERRVLELLR-----ENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLI-EKERVGRENVVELP 74


                 ..
gi 446993257  81 PQ 82
Cdd:COG2512   75 ED 76
HTH_36 pfam13730
Helix-turn-helix domain;
11-65 6.49e-05

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 37.47  E-value: 6.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446993257   11 NELNHDQMRVLMALLAELDYENYIQVAQIDIAEALTMQKTNVSRAVKNLIDFGII 65
Cdd:pfam13730   1 LRLSPTAKLLLLILASYANKDGGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
40-86 9.22e-04

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 36.45  E-value: 9.22e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446993257  40 DIAEALTMQKTNVSRAVKNLIDFGIILEGPKIG-RSKTYRLNPQFgWK 86
Cdd:COG1510   47 ELAEELGVSKSSVSTALRELEDWGLVRRVRKPGdRKDYFRAEKDV-WE 93
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
40-81 1.12e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.01  E-value: 1.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 446993257  40 DIAEALTMQKTNVSRAVKNLIDFGIIlEGPKIGRSKTYRLNP 81
Cdd:COG3398  116 ELAEELGISRSTVSWHLKRLEEDGLV-ERERDGRNVRYYLNP 156
Phage_rep_O pfam04492
Bacteriophage replication protein O; Replication protein O is necessary for the initiation of ...
 7-77 1.63e-03

Bacteriophage replication protein O; Replication protein O is necessary for the initiation of bacteriophage DNA replication. Protein O interacts with the lambda replication origin, and also with replication protein P to form an oligomer. It is speculated that the N-terminal half interacts with the replication origin while the C terminal half mediates protein-protein interaction (annotation of Swiss: P14815).


Pssm-ID: 461329  Cd Length: 92  Bit Score: 34.91  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446993257    7 ITIANE---------LNHDQMRVLMALlAELDYENYIQVAQI---DIAEALTMQKTNVSRAVKNLIDFGII-LEGPKIGR 73
Cdd:pfam04492   7 TRLANEllealiradLTKRQLKILLAV-IRKTYGFNKKSDWIsnsQLAELTGISRTHVSKALKELIRMNVIiKDGRKVGV 85


                  ....
gi 446993257   74 SKTY 77
Cdd:pfam04492  86 NKNY 89
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
40-80 1.83e-03

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 36.05  E-value: 1.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 446993257  40 DIAEALTMQKTNVSRAVKNLIDFGIILEGPKIGRSK--TYRLN 80
Cdd:COG1672  263 EIASALGISSSSLSRYLKNLIDLGIIEKEVPVEKSKkgRYRIA 305
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
40-82 3.71e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 33.71  E-value: 3.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 446993257  40 DIAEALTMQKTNVSRAVKNLIDFGIIlEGPKIGRSKTYRLNPQ 82
Cdd:COG0640   38 ELAEALGLSQSTVSHHLKVLREAGLV-TSRREGRWVYYRLADE 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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