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Conserved domains on  [gi|446995725|ref|WP_001072981|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacillus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
5-100 1.25e-51

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 157.72  E-value: 1.25e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725   5 DNCPIATTLDVIGGKWKVHILCILSDGKMRTNEIKREIPNITQKVLTQQLRQLEADGIIYRTVYQEVPPKVEYTLSEYGK 84
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                         90
                 ....*....|....*.
gi 446995725  85 SLMQIMDNLFEWGKDH 100
Cdd:COG1733   88 SLLPVLDALAEWGEEH 103
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
5-100 1.25e-51

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 157.72  E-value: 1.25e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725   5 DNCPIATTLDVIGGKWKVHILCILSDGKMRTNEIKREIPNITQKVLTQQLRQLEADGIIYRTVYQEVPPKVEYTLSEYGK 84
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                         90
                 ....*....|....*.
gi 446995725  85 SLMQIMDNLFEWGKDH 100
Cdd:COG1733   88 SLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 15-100 1.94e-41

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 131.66  E-value: 1.94e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725   15 VIGGKWKVHILCILSDGKMRTNEIKREIPNITQKVLTQQLRQLEADGIIYRTVYQEVPPKVEYTLSEYGKSLMQIMDNLF 94
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*.
gi 446995725   95 EWGKDH 100
Cdd:pfam01638  81 DWGEEY 86
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 13-95 7.40e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.06  E-value: 7.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725  13 LDVIGGKWKVHILCILSDGKMRTNEIKREIpNITQKVLTQQLRQLEADGIIyrtVYQEVPPKVEYTLSEyGKSLMQIMDN 92
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLV---ESRREGRRVYYSLTD-AERLLALLES 75


                 ...
gi 446995725  93 LFE 95
Cdd:cd00090   76 LLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
24-81 5.75e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.96  E-value: 5.75e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446995725    24 ILCILSDGKMRTNEIKREIpNITQKVLTQQLRQLEADGIIyrtVYQEVPPKVEYTLSE 81
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLV---ESRREGKRVYYSLTD 55
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
5-100 1.25e-51

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 157.72  E-value: 1.25e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725   5 DNCPIATTLDVIGGKWKVHILCILSDGKMRTNEIKREIPNITQKVLTQQLRQLEADGIIYRTVYQEVPPKVEYTLSEYGK 84
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                         90
                 ....*....|....*.
gi 446995725  85 SLMQIMDNLFEWGKDH 100
Cdd:COG1733   88 SLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 15-100 1.94e-41

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 131.66  E-value: 1.94e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725   15 VIGGKWKVHILCILSDGKMRTNEIKREIPNITQKVLTQQLRQLEADGIIYRTVYQEVPPKVEYTLSEYGKSLMQIMDNLF 94
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*.
gi 446995725   95 EWGKDH 100
Cdd:pfam01638  81 DWGEEY 86
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 13-95 7.40e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.06  E-value: 7.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725  13 LDVIGGKWKVHILCILSDGKMRTNEIKREIpNITQKVLTQQLRQLEADGIIyrtVYQEVPPKVEYTLSEyGKSLMQIMDN 92
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLV---ESRREGRRVYYSLTD-AERLLALLES 75


                 ...
gi 446995725  93 LFE 95
Cdd:cd00090   76 LLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
24-81 5.75e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.96  E-value: 5.75e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446995725    24 ILCILSDGKMRTNEIKREIpNITQKVLTQQLRQLEADGIIyrtVYQEVPPKVEYTLSE 81
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLV---ESRREGKRVYYSLTD 55
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
9-100 3.28e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 36.41  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446995725   9 IATTLDVIGGKWKVHILCILSDGKMRTNEIKREIpNITQKVLTQQLRQLEADGIIY-----RTVYqevppkveYTLSEyg 83
Cdd:COG0640   10 LAELFKALADPTRLRILRLLAEGELCVGELAEAL-GLSQSTVSHHLKVLREAGLVTsrregRWVY--------YRLAD-- 78

                         90
                 ....*....|....*..
gi 446995725  84 kslmQIMDNLFEWGKDH 100
Cdd:COG0640   79 ----EALAELLEWLLEL 91
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 21-63 4.51e-04

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 35.11  E-value: 4.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 446995725   21 KVHILCILSDGKMRTNEIKREIpNITQKVLTQQLRQLEADGII 63
Cdd:pfam01022   4 RLKILKLLAEGELCVCELAEEL-GLSQSTVSHHLKKLREAGLV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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