NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446997392|ref|WP_001074648|]
View 

MULTISPECIES: ABC transporter permease subunit [Bacillus]

Protein Classification

ABC transporter permease( domain architecture ID 359)

ABC transporter permease is the transmembrane subunit (TM) found in type 1 periplasmic-binding protein (PBP1)-dependent ATP-binding cassette (ABC) transporters which generally involved in the uptake of a broad range of substrates including metal ions, amino acids, sugars and peptides

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TM_PBP1_branched-chain-AA_like super family cl00454
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette ...
 13-309 2.13e-120

Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of monosaccharides including ribose, galactose, and arabinose. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. This group includes Escherichia coli LivM and LivH, two TMs which heterodimerize to form the translocation pathway of the E. coli branched-chain AA LIV-1/LS transporter. This transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) and LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine. Included in this group are proteins from transport systems that contain a single TM which homodimerizes to generate the transmembrane pore; for example E. coli RbsC, AlsC, and MglC, the TMs of the high affinity ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also to be involved in low affinity ribose transport.


The actual alignment was detected with superfamily member PRK09512:

Pssm-ID: 444914 [Multi-domain]  Cd Length: 320  Bit Score: 348.25  E-value: 2.13e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  13 SLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMASGMDPFLAM 92
Cdd:PRK09512  21 SLIALLVLIAIVSTLSPNFFTVNNLFNILQQTSVNAIMAVGMTLVILTSGIDLSVGSLLALTGAVAASIVGIEVNALVAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  93 AVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPI-TGLGDHL-MFQMFGRGYFLGIPVPAVTMMI 170
Cdd:PRK09512 101 PAALALGAAIGAVTGVIVAKGKVQAFIATLVMMLLLRGVTMVYTDGSPInTGFTDNAdLFGWFGIGRPLGIPTPVWIMAI 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 171 AFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAV 250
Cdd:PRK09512 181 VFLAAWYMLHHTRLGRYIYALGGNEAATRLSGINVNKVKIIVYALCGLLAALAGIIEVARLSSAQPTAGTGYELDAIAAV 260

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446997392 251 VLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDRRK 309
Cdd:PRK09512 261 VLGGTSLAGGKGRIVGTLIGALILGFLNNGLNLLGVSSYYQMIVKAVVILLAVLVDNKK 319
 
Name Accession Description Interval E-value
rbsC PRK09512
ribose ABC transporter permease protein; Reviewed
 13-309 2.13e-120

ribose ABC transporter permease protein; Reviewed


Pssm-ID: 181922 [Multi-domain]  Cd Length: 320  Bit Score: 348.25  E-value: 2.13e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  13 SLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMASGMDPFLAM 92
Cdd:PRK09512  21 SLIALLVLIAIVSTLSPNFFTVNNLFNILQQTSVNAIMAVGMTLVILTSGIDLSVGSLLALTGAVAASIVGIEVNALVAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  93 AVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPI-TGLGDHL-MFQMFGRGYFLGIPVPAVTMMI 170
Cdd:PRK09512 101 PAALALGAAIGAVTGVIVAKGKVQAFIATLVMMLLLRGVTMVYTDGSPInTGFTDNAdLFGWFGIGRPLGIPTPVWIMAI 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 171 AFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAV 250
Cdd:PRK09512 181 VFLAAWYMLHHTRLGRYIYALGGNEAATRLSGINVNKVKIIVYALCGLLAALAGIIEVARLSSAQPTAGTGYELDAIAAV 260

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446997392 251 VLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDRRK 309
Cdd:PRK09512 261 VLGGTSLAGGKGRIVGTLIGALILGFLNNGLNLLGVSSYYQMIVKAVVILLAVLVDNKK 319
AraH COG1172
Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component ...
 8-309 4.26e-114

Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440785  Cd Length: 322  Bit Score: 332.46  E-value: 4.26e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   8 LQQLGSLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMM-ASGM 86
Cdd:COG1172   16 LPELGLLLALVLLLVVFSILSPGFLSPGNLSNILRQAAILGILALGMTLVIITGGIDLSVGSVVALSGVVAALLLvALGL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  87 DPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGLGDhlMFQMFGRGYFLGIPVPAV 166
Cdd:COG1172   96 PILLAILLALLVGALLGLLNGLLVAKLRIPPFIVTLGTMFIARGLALLLTGGRPISGLPD--AFRALGQGSLLGIPVPVL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 167 TMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDA 246
Cdd:COG1172  174 IALVVALVAWFLLRRTRFGRYIYAVGGNEEAARLSGINVRRVKILAYVLSGLLAGLAGILLAARLGSAQPNAGSGYELDA 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446997392 247 IAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDRRK 309
Cdd:COG1172  254 IAAVVIGGTSLTGGRGSVLGTLLGALILGVLNNGLNLLGVSSYWQQIVKGAIILLAVLLDRLR 316
TM_PBP1_transp_AraH_like cd06579
Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the ...
 44-306 1.03e-91

Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.


Pssm-ID: 119321 [Multi-domain]  Cd Length: 263  Bit Score: 273.52  E-value: 1.03e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  44 VSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMAS-GMDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATL 122
Cdd:cd06579    1 AAVLGILALGMTLVIITGGIDLSVGSVAALSAVVAALLLVNaGLPIPLAILAALAVGALIGLLNGLLVAYLRIPPFIVTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 123 ATMTIFRGLTLVYMDGRPITGLGDhLMFQMFGRGYFLGIPVPAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSG 202
Cdd:cd06579   81 GTMFILRGLALLITGGRPISGLPP-LFSFFLGGGLILGIPVPVLIALAVALVAWFLLRRTRFGRYLYAVGGNPEAARLSG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 203 INVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLN 282
Cdd:cd06579  160 INVRRVKILAYVLSGLLAGLAGILLAARLGSAQPTAGNGYELDAIAAVVLGGTSLTGGRGSVLGTLLGALLLGVLNNGLN 239

                        250       260
                 ....*....|....*....|....
gi 446997392 283 LLGVSSFFQQVVKGLVILLAVLID 306
Cdd:cd06579  240 LLGVSSFWQQIVKGAILLLAVALD 263
GguB NF040906
sugar ABC transporter permease;
8-306 4.03e-70

sugar ABC transporter permease;


Pssm-ID: 468841 [Multi-domain]  Cd Length: 375  Bit Score: 221.95  E-value: 4.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   8 LQQLGSLIGLVLIIVVITVLNPAFIEIP-NLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMAS-G 85
Cdd:NF040906   2 LRQYGMLIALVAIVVLFQILTGGILLRPlNVTNLILQNSYILILAIGMLLVIIAGHIDLSVGSVVAFVGAVAAVLMVNwG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  86 MDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGLGDHlmFQMFGRGY-------- 157
Cdd:NF040906  82 MPWWLAVLLCLLVGALIGAWQGFWVAYVGIPAFIVTLAGMLVFRGLTLVVLGGQSIGPFPDG--FQKISSGFlpdlfggt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 158 -------------------------------------------------------------FLGIPVPAVTMMIAFAVLY 176
Cdd:NF040906 160 glhlltlllgvlaaaalvwsqlrgrrrrikyglevepmalfiaklvliaaailfftyllasYRGLPNVLIILGVLILVYS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 177 FILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVLGGTS 256
Cdd:NF040906 240 FVTNRTVIGRHIYAVGGNEKAAKLSGIKTKRVTFLVFVNMGVLAALAGLVFAARLNSATPKAGNGFELDAIAACFIGGAS 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 446997392 257 LSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLID 306
Cdd:NF040906 320 ASGGVGTVVGAIIGALVMGVLNNGMSILGIGIDWQQVIKGLVLLAAVAFD 369
BPD_transp_2 pfam02653
Branched-chain amino acid transport system / permease component; This is a large family mainly ...
 36-303 1.25e-27

Branched-chain amino acid transport system / permease component; This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH and LivM, both of which are form the LIV-I transport system. Also found with in this family are proteins from the galactose transport system permease and a ribose transport system.


Pssm-ID: 396977 [Multi-domain]  Cd Length: 269  Bit Score: 108.11  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   36 NLFNILRQVSINALIAFGMTFVI-LTGGIDLSVGSILALSSALVAGMMAS-GMDPFLAMAVGLLAGLVMGIINGIIIAKG 113
Cdd:pfam02653   1 NILNILTLASIYAIAALGLTLIYgIAGVINLGHGGFMMLGAYVAAMLLNLlGPGLWLALPVGILVGAAVGLLIGILTLRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  114 KVAPFIATLATMTIFRGLTLVYMDGR---PITGLGDHLMFQMFGRGYFLGIPVPAVTMMIAFAVLYFILKKTTFGRRTFA 190
Cdd:pfam02653  81 KINEVIITLLLNLAALGLALFLVTGIlggEGGTSGITGPSGFPGAFLSFAFAFIFLLALLLVLALWLLLYRTKFGRALRA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  191 IGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPT-AGTSYELDAIAAVVLGGTslsggrGWIVGTFI 269
Cdd:pfam02653 161 VGENEEAARAAGINVKKLKLLTFVISGALAGLAGALLALYTGVVPPSnFGVGLGLDAIAAVVLGGA------GSPIGVVI 234

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 446997392  270 GVLIIGVLNN-GLNLLGVSSFFQQVVKGLVILLAV 303
Cdd:pfam02653 235 GSLIIGLVQSlGLGALGSPPELSLLVLGALLILVL 269
 
Name Accession Description Interval E-value
rbsC PRK09512
ribose ABC transporter permease protein; Reviewed
 13-309 2.13e-120

ribose ABC transporter permease protein; Reviewed


Pssm-ID: 181922 [Multi-domain]  Cd Length: 320  Bit Score: 348.25  E-value: 2.13e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  13 SLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMASGMDPFLAM 92
Cdd:PRK09512  21 SLIALLVLIAIVSTLSPNFFTVNNLFNILQQTSVNAIMAVGMTLVILTSGIDLSVGSLLALTGAVAASIVGIEVNALVAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  93 AVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPI-TGLGDHL-MFQMFGRGYFLGIPVPAVTMMI 170
Cdd:PRK09512 101 PAALALGAAIGAVTGVIVAKGKVQAFIATLVMMLLLRGVTMVYTDGSPInTGFTDNAdLFGWFGIGRPLGIPTPVWIMAI 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 171 AFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAV 250
Cdd:PRK09512 181 VFLAAWYMLHHTRLGRYIYALGGNEAATRLSGINVNKVKIIVYALCGLLAALAGIIEVARLSSAQPTAGTGYELDAIAAV 260

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446997392 251 VLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDRRK 309
Cdd:PRK09512 261 VLGGTSLAGGKGRIVGTLIGALILGFLNNGLNLLGVSSYYQMIVKAVVILLAVLVDNKK 319
AraH COG1172
Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component ...
 8-309 4.26e-114

Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440785  Cd Length: 322  Bit Score: 332.46  E-value: 4.26e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   8 LQQLGSLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMM-ASGM 86
Cdd:COG1172   16 LPELGLLLALVLLLVVFSILSPGFLSPGNLSNILRQAAILGILALGMTLVIITGGIDLSVGSVVALSGVVAALLLvALGL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  87 DPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGLGDhlMFQMFGRGYFLGIPVPAV 166
Cdd:COG1172   96 PILLAILLALLVGALLGLLNGLLVAKLRIPPFIVTLGTMFIARGLALLLTGGRPISGLPD--AFRALGQGSLLGIPVPVL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 167 TMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDA 246
Cdd:COG1172  174 IALVVALVAWFLLRRTRFGRYIYAVGGNEEAARLSGINVRRVKILAYVLSGLLAGLAGILLAARLGSAQPNAGSGYELDA 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446997392 247 IAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDRRK 309
Cdd:COG1172  254 IAAVVIGGTSLTGGRGSVLGTLLGALILGVLNNGLNLLGVSSYWQQIVKGAIILLAVLLDRLR 316
COG4158 COG4158
Predicted ABC-type sugar transport system, permease component [General function prediction ...
 5-307 8.27e-93

Predicted ABC-type sugar transport system, permease component [General function prediction only];


Pssm-ID: 443324  Cd Length: 334  Bit Score: 278.74  E-value: 8.27e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   5 GNVLQQLGSLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSalVAGMMAS 84
Cdd:COG4158   24 RSLLQAVGMLPVLILLCIGFELLTPNFLTVQNLSNIARQASINIVLAAGMTFVILTGGIDLSVGSILAASA--VVAVLVS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  85 GMD--PFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPItgLGDHLMFQMFGRGYFLGIP 162
Cdd:COG4158  102 LLPglGLLGIPAALLVGLLFGLINGLLIAFLKLPPFIVTLGSLTALRGAARLLANGTTV--FNPDLPFAWIGNGYLLGIP 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 163 VPAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPT-AGTS 241
Cdd:COG4158  180 WLVVIALAVVLASWFILRRTVLGVHIYAVGGNAQAARLTGIKVWRVLLFVYAVSGLLAGLGGVMSAARLYAANGLqLGQG 259

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446997392 242 YELDAIAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDR 307
Cdd:COG4158  260 YELDAIAAVILGGTSFVGGIGSIWGTLIGALIIAVLNNGLILLGVSDFWQFIIKGLVIIIAVALDR 325
TM_PBP1_transp_AraH_like cd06579
Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the ...
 44-306 1.03e-91

Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.


Pssm-ID: 119321 [Multi-domain]  Cd Length: 263  Bit Score: 273.52  E-value: 1.03e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  44 VSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMAS-GMDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATL 122
Cdd:cd06579    1 AAVLGILALGMTLVIITGGIDLSVGSVAALSAVVAALLLVNaGLPIPLAILAALAVGALIGLLNGLLVAYLRIPPFIVTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 123 ATMTIFRGLTLVYMDGRPITGLGDhLMFQMFGRGYFLGIPVPAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSG 202
Cdd:cd06579   81 GTMFILRGLALLITGGRPISGLPP-LFSFFLGGGLILGIPVPVLIALAVALVAWFLLRRTRFGRYLYAVGGNPEAARLSG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 203 INVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLN 282
Cdd:cd06579  160 INVRRVKILAYVLSGLLAGLAGILLAARLGSAQPTAGNGYELDAIAAVVLGGTSLTGGRGSVLGTLLGALLLGVLNNGLN 239

                        250       260
                 ....*....|....*....|....
gi 446997392 283 LLGVSSFFQQVVKGLVILLAVLID 306
Cdd:cd06579  240 LLGVSSFWQQIVKGAILLLAVALD 263
XylH COG4214
ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism];
8-306 2.28e-88

ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443360 [Multi-domain]  Cd Length: 393  Bit Score: 269.29  E-value: 2.28e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   8 LQQLGSLIGLVLIIVVITVLN-PAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMAS-G 85
Cdd:COG4214   22 LRSLGMIIALVVIWIVFQILTgGTFLTPRNLSNLLLQNSYIGILAIGMVLVILLGHIDLSVGSVSGFVGAVAAVLMVNwG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  86 MDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGLGDHlmFQMFGRGY-------- 157
Cdd:COG4214  102 LPWWLAILAALLVGALIGAWQGFWVAYVGIPSFIVTLAGMLAFRGLTLLVLGGGTIAPFDPT--FQAIGNGFlpdilgtl 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 158 --------------------------------------------------------FLGIPVPAVTMMIAFAVLYFILKK 181
Cdd:COG4214  180 swvlgavavaayvalqlrsrrrrrryglpveplwlfvlklallavlilgavyllnsYRGIPIVVLILLVLVVVYTFVLTR 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 182 TTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVLGGTSLSGGR 261
Cdd:COG4214  260 TVFGRHIYAVGGNPEAARLSGINVRRVTFSVFVNMGVLAALAGIVFAARLNSATPSAGTGFELDAIAAAVIGGTSLFGGV 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 446997392 262 GWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLID 306
Cdd:COG4214  340 GTVYGAVIGALVMGSLNNGMSLLGVDSDWQQIVKGLVLLLAVAFD 384
araH PRK11285
L-arabinose transporter permease protein; Provisional
 2-310 1.22e-73

L-arabinose transporter permease protein; Provisional


Pssm-ID: 183076 [Multi-domain]  Cd Length: 333  Bit Score: 229.56  E-value: 1.22e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   2 AKKGNVLQQLGSLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGM 81
Cdd:PRK11285  21 FSLWRIWDQYGMLVVFAVLFIACSLFVPNFASFINMKGLGLAISMIGMVACTMLFCLASGDFDLSVASVVAFAGVVTAVV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  82 MASGMDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPItGLGDHLMFQmFGRGYFLGI 161
Cdd:PRK11285 101 INATESLWLGVAAGLLLGAAVGLVNGFVIARLKINALITTLATMQIVRGLAYIISDGKAV-GISDERFFA-LGYANFFGV 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 162 PVPAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTS 241
Cdd:PRK11285 179 PAPIWLTVACFVVFGFLLNKTTFGRNTLAIGGNEEAARLAGVPVVRTKIIIFVLQGLVSALAGVILASRMTSGQPMTSIG 258

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446997392 242 YELDAIAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDRRKE 310
Cdd:PRK11285 259 FELIVISACVLGGVSLKGGIAKISGVVAGVLILGTVENAMNLLNISPFYQYVVRGLILLAAVLFDRYKQ 327
GguB NF040906
sugar ABC transporter permease;
8-306 4.03e-70

sugar ABC transporter permease;


Pssm-ID: 468841 [Multi-domain]  Cd Length: 375  Bit Score: 221.95  E-value: 4.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   8 LQQLGSLIGLVLIIVVITVLNPAFIEIP-NLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMAS-G 85
Cdd:NF040906   2 LRQYGMLIALVAIVVLFQILTGGILLRPlNVTNLILQNSYILILAIGMLLVIIAGHIDLSVGSVVAFVGAVAAVLMVNwG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  86 MDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGLGDHlmFQMFGRGY-------- 157
Cdd:NF040906  82 MPWWLAVLLCLLVGALIGAWQGFWVAYVGIPAFIVTLAGMLVFRGLTLVVLGGQSIGPFPDG--FQKISSGFlpdlfggt 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 158 -------------------------------------------------------------FLGIPVPAVTMMIAFAVLY 176
Cdd:NF040906 160 glhlltlllgvlaaaalvwsqlrgrrrrikyglevepmalfiaklvliaaailfftyllasYRGLPNVLIILGVLILVYS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 177 FILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVLGGTS 256
Cdd:NF040906 240 FVTNRTVIGRHIYAVGGNEKAAKLSGIKTKRVTFLVFVNMGVLAALAGLVFAARLNSATPKAGNGFELDAIAACFIGGAS 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 446997392 257 LSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLID 306
Cdd:NF040906 320 ASGGVGTVVGAIIGALVMGVLNNGMSILGIGIDWQQVIKGLVLLAAVAFD 369
PRK09699 PRK09699
D-allose ABC transporter permease;
6-307 4.94e-69

D-allose ABC transporter permease;


Pssm-ID: 182035 [Multi-domain]  Cd Length: 312  Bit Score: 217.33  E-value: 4.94e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   6 NVLQQLGSLIGLVLIIVVITVLNP-AFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMAS 84
Cdd:PRK09699   7 LFWDKYGTFFILAIIVAIFGSLSPeYFLTTNNITQIFVQSSVTVLIGMGEFFAILVAGIDLSVGAILALSGMVTAKLMLA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  85 GMDPFLAMAVG-LLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGLGdhLMFQMFGRGYFLGIPV 163
Cdd:PRK09699  87 GVDPFLAALIGgVLVGGALGAINGCLVNWTGLHPFIITLGTNAIFRGITLVISDANSVYGFS--FDFVNFFAASVIGIPV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 164 PAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYE 243
Cdd:PRK09699 165 PVIFSLIVALILWFLTTRMRLGRNIYALGGNKNSAFYSGIDVKFHILVVFIISGVCAGLAGVVSTARLGAAEPLAGMGFE 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446997392 244 LDAIAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDR 307
Cdd:PRK09699 245 TYAIASAIIGGTSFFGGKGRIFSVVIGGLIIGTINNGLNILQVQTYYQLVVMGGLIIAAVALDR 308
mglC PRK09478
galactose/methyl galactoside ABC transporter permease MglC;
6-311 2.69e-63

galactose/methyl galactoside ABC transporter permease MglC;


Pssm-ID: 181892 [Multi-domain]  Cd Length: 336  Bit Score: 203.38  E-value: 2.69e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   6 NVLQQLGSLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMASG 85
Cdd:PRK09478  11 TYLKEGGIYVVLLVLLAIIIIQDPTFLSLLNLSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAAVVAATLLQSM 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  86 MDP------------FLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMD---GRPITGLGDHlmF 150
Cdd:PRK09478  91 DNAnkvfpelatmpiALVILIVCAIGAVIGLINGLIIAYLNVTPFIATLGTMIIVYGINSLYYDfvgASPISGFDSG--F 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 151 QMFGRGYF----LGIPVPAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIV 226
Cdd:PRK09478 169 STFAQGFValgsFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVPLNLLMIYALSGVFYAFGGML 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 227 LTSRLDSAQPTAGTSYELDAIAAVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLID 306
Cdd:PRK09478 249 EAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAIIIFAVALD 328


                 ....*
gi 446997392 307 RRKEA 311
Cdd:PRK09478 329 SLKYA 333
PRK11618 PRK11618
inner membrane ABC transporter permease protein YjfF; Provisional
 17-307 4.49e-46

inner membrane ABC transporter permease protein YjfF; Provisional


Pssm-ID: 183235 [Multi-domain]  Cd Length: 317  Bit Score: 158.19  E-value: 4.49e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  17 LVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMAS-GMDPFLAMAVG 95
Cdd:PRK11618  15 FVLGYLFCLVQFPGFASTRVICNLLTDNAFLGIVAVGMTFVILSGGIDLSVGSVIAFTGVFLAKLIGDyGWSPLLAFPLV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  96 LLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGL-TLVYMDGRPITGLGDH----LMFQMFGRGYflgIPVPAVTMMI 170
Cdd:PRK11618  95 LVMGAAFGAFMGALIHYLKLPAFIVTLAGMFLARGVsFLVSEESIPINHPFYDtlssLAWKLPGGGR---LSAMALIMLA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 171 AFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAV 250
Cdd:PRK11618 172 VVAIGIFLAHRTRFGNNVYAIGGNATSANLMGIPVRRTTIRIYMLSGFLATLAGIVFSLYTSAGYALAAVGVELDAIAAV 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446997392 251 VLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLG-VSSFFQQVVKGLVILLAVLIDR 307
Cdd:PRK11618 252 VIGGTLLTGGVGTVLGTLFGVLIQGLIQTYITFDGtLSSWWTKIVIGILLFVFIALQR 309
PRK15432 PRK15432
autoinducer 2 ABC transporter permease LsrC; Provisional
 9-308 1.09e-44

autoinducer 2 ABC transporter permease LsrC; Provisional


Pssm-ID: 185330 [Multi-domain]  Cd Length: 344  Bit Score: 155.27  E-value: 1.09e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   9 QQLGSLIGLVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMASGMDP 88
Cdd:PRK15432   9 RELTALLAIVLLFVLLGFLDRQYLSLQTLTMVFSSAQILILLAIGATLVMLTRNIDVSVGSITGLCAVLVGMLLNAGYSL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  89 FLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGLGDHLmfQMFGRGYFLGIPVPAVTM 168
Cdd:PRK15432  89 PVACLATLLLGLLAGFFNGVLVAWLRIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAEL--KQLSAPILLGISPIGWLT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 169 MIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIA 248
Cdd:PRK15432 167 LILILAMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGLEMKAIA 246

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 249 AVVLGGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVLIDRR 308
Cdd:PRK15432 247 ACVLGGISLLGGSGTIIGAVLGAYFLTQIDSVLVLLRIPAWWNDFIAGLVLLGVLVFDGR 306
PRK15038 PRK15038
autoinducer 2 ABC transporter permease LsrD;
17-304 3.48e-35

autoinducer 2 ABC transporter permease LsrD;


Pssm-ID: 184998  Cd Length: 330  Bit Score: 129.95  E-value: 3.48e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  17 LVLIIVVITVLNPAFIEIPNLFNILRQVSINALIAFGMTFVILTGGIDLSVGSILALSSALVAGMMASGMDPFLAMAVGL 96
Cdd:PRK15038  15 LVIEILAFGLINPRMLDINVLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIALGVLFQSGVPMPLAILLTL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  97 LAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMDGRPITGL----GDHLMFQMFGRGYFLGIPVPAVTMMIAF 172
Cdd:PRK15038  95 LLGALCGLINAGLIIYTGVNPLVITLGTLYLFGGSALLLSGMAGATGYegigGFPMAFTDFANLDVLGLPVPLIIFLICL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 173 AVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVL 252
Cdd:PRK15038 175 LVFWLLMHRTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAIAAVLLVSYFGSARSDLGASFLMPAITAVVL 254

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446997392 253 GGTSLSGGRGWIVGTFIGVLIIGVLNNGLNLLGVSSFFQQVVKGLVILLAVL 304
Cdd:PRK15038 255 GGANIYGGSGSIIGTALAVLLVGYLQQGLQMAGVPNQISSALSGALLIVVVV 306
TM_PBP1_branched-chain-AA_like cd06574
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette ...
 45-303 3.25e-28

Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of monosaccharides including ribose, galactose, and arabinose. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. This group includes Escherichia coli LivM and LivH, two TMs which heterodimerize to form the translocation pathway of the E. coli branched-chain AA LIV-1/LS transporter. This transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) and LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine. Included in this group are proteins from transport systems that contain a single TM which homodimerizes to generate the transmembrane pore; for example E. coli RbsC, AlsC, and MglC, the TMs of the high affinity ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also to be involved in low affinity ribose transport.


Pssm-ID: 119320 [Multi-domain]  Cd Length: 266  Bit Score: 109.67  E-value: 3.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  45 SINALIAFGMTFVILTGGI-DLSVGSILALSSALVAGMMASGMDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLA 123
Cdd:cd06574    2 LIYAILALGVYIVFRILGFpDLTVDGSFPLGAAVAAILIVAGYNPWLALIAAILAGAAAGLVTGFLHTRLKINGLLAGIL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 124 TMTIFRGLTLVYMDGRPITGLGDHLMF---QMFGRGYFLGIPVPAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAAL 200
Cdd:cd06574   82 IMIGLYSINLRIMGGPNIPLGTRDTLLgllLLFGISGTLSIPVVLLLIVLLVLFLVIWFLRTKLGLAMRATGDNPDMARS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 201 SGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVLGGTSLSGGRGW--IVGTFIGVLIIGVLN 278
Cdd:cd06574  162 LGINVDRTRILGLVISNALAALGGALYAQYQGFADVNMGIGTGVIGLAAVIIGGAIVGRRTIKasILGVIIGAILYRIAL 241

                        250       260
                 ....*....|....*....|....*
gi 446997392 279 NGLNLLGVSSFFQQVVKGLVILLAV 303
Cdd:cd06574  242 ALALGSGLIPSDLKLITAGVIVLVL 266
BPD_transp_2 pfam02653
Branched-chain amino acid transport system / permease component; This is a large family mainly ...
 36-303 1.25e-27

Branched-chain amino acid transport system / permease component; This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH and LivM, both of which are form the LIV-I transport system. Also found with in this family are proteins from the galactose transport system permease and a ribose transport system.


Pssm-ID: 396977 [Multi-domain]  Cd Length: 269  Bit Score: 108.11  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392   36 NLFNILRQVSINALIAFGMTFVI-LTGGIDLSVGSILALSSALVAGMMAS-GMDPFLAMAVGLLAGLVMGIINGIIIAKG 113
Cdd:pfam02653   1 NILNILTLASIYAIAALGLTLIYgIAGVINLGHGGFMMLGAYVAAMLLNLlGPGLWLALPVGILVGAAVGLLIGILTLRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  114 KVAPFIATLATMTIFRGLTLVYMDGR---PITGLGDHLMFQMFGRGYFLGIPVPAVTMMIAFAVLYFILKKTTFGRRTFA 190
Cdd:pfam02653  81 KINEVIITLLLNLAALGLALFLVTGIlggEGGTSGITGPSGFPGAFLSFAFAFIFLLALLLVLALWLLLYRTKFGRALRA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  191 IGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPT-AGTSYELDAIAAVVLGGTslsggrGWIVGTFI 269
Cdd:pfam02653 161 VGENEEAARAAGINVKKLKLLTFVISGALAGLAGALLALYTGVVPPSnFGVGLGLDAIAAVVLGGA------GSPIGVVI 234

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 446997392  270 GVLIIGVLNN-GLNLLGVSSFFQQVVKGLVILLAV 303
Cdd:pfam02653 235 GSLIIGLVQSlGLGALGSPPELSLLVLGALLILVL 269
LivH COG0559
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport ...
 34-305 7.11e-19

Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440325 [Multi-domain]  Cd Length: 290  Bit Score: 84.73  E-value: 7.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  34 IPNLFNILRQVSINALIAFGMTFV-ILTGGIDLSVGSILALSS-ALVAGMMASGMDPFLAMAVGLLAGLVMGIINGIIIA 111
Cdd:COG0559    5 LQQLLNGLSLGSIYALIALGLTLIfGVMGVINFAHGEFVMLGAyVAYTLATLLGLPLWLALLLAVLVAALLGVLLERLVI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 112 K-----GKVAPFIATLATMTIFRGLTLVYMDGRPITglgdhLMFQMFGRGYFLGIPVPAVTMMI------AFAVLYFILK 180
Cdd:COG0559   85 RplrgaPPLALLLATIGLSLVLQGLVLLIFGADPRS-----FPALLSGSVELGGVSIPAYRLFIivvalvLLAALWLFLR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 181 KTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLdSAQPTAGTSYELDAIAAVVLGGTslsgg 260
Cdd:COG0559  160 RTRLGLAMRAVAQNREAARLMGINVDRVIALTFALGAALAGLAGVLLAPIY-SVSPTMGFLLGLKAFAAVVLGGL----- 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446997392 261 rGWIVGTFIGVLIIGVLNNGLNLLgVSSFFQQVVkGLVILLAVLI 305
Cdd:COG0559  234 -GSIPGAVVGGLLLGLAESLGAAY-LPSGYKDVV-AFVLLILVLL 275
TM_PBP1_LivH_like cd06582
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two ...
 45-307 2.07e-17

Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.


Pssm-ID: 119324 [Multi-domain]  Cd Length: 272  Bit Score: 80.17  E-value: 2.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  45 SINALIAFGMTFVI-LTGGIDLSVGSILALSS-ALVAGMMASGMDPFLAMAVGLLAGLVMGIINGIII----AKGKVAPF 118
Cdd:cd06582    6 AIYALIALGLTLIFgVTGVINFAHGEFYMLGAyVAYTLLVALGLPFWLALLLALLVAALLGVLLERLVlrplRGAPLLTL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 119 IATLATMTIFRGLTLVYMDGRPITGLGDHLMFQMFGRGYFLGIP--VPAVTMMIAFAVLYFILKKTTFGRRTFAIGGNEE 196
Cdd:cd06582   86 LITFGGLLILLQGLLLIFGGDPRVPPPPLLSGSVELGGVTIPPYrlFIIAVALVLLAALYLFLRRTRLGRAIRAVAQNPE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 197 AAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLdSAQPTAGTSYELDAIAAVVLGGTslsggrGWIVGTFIGVLIIGV 276
Cdd:cd06582  166 AARLLGINVRRVFALTFALGAALAGLAGVLLAPIT-GVSPTMGLLLLLKAFAAVVLGGL------GSIPGAVVGGLLLGL 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 446997392 277 LNNGLNLLgVSSFFQQVVkGLVILLAVLIDR 307
Cdd:cd06582  239 AESLAAAY-LSSGYKDAV-AFVLLILVLLVR 267
LivM COG4177
ABC-type branched-chain amino acid transport system, permease component [Amino acid transport ...
 35-304 9.08e-15

ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443336 [Multi-domain]  Cd Length: 285  Bit Score: 73.19  E-value: 9.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  35 PNLFNILRQVSINALIAFGMTFVI-LTGGIDLSVGSILALSsALVAGMMAS--GMDPFLAMAVGLLAGLVMGIINGIIIA 111
Cdd:COG4177    2 PYYLSLLTLILIYAILALGLNLLLgYTGLLSLGHAAFFGIG-AYAAALLTThlGLPFWLALLLAGLVAALLGLLIGLPAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 112 KGKVAPF-IATLA----TMTIFRGLTLVYMDGRPITGLGDHLMFQMFGRGYFLGIPVPAVTMMIAFAVLYFILKkTTFGR 186
Cdd:COG4177   81 RLRGDYLaIATLAfaeiVRLLALNLESLTGGADGLSGIPRPTLFGLDLGSPLAFYYLVLALLVLVLLLLRRLVR-SRFGR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 187 RTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTA-GTSYELDAIAAVVLggtslsGGRGWIV 265
Cdd:COG4177  160 ALRAIRENEIAAEALGINVTRYKLLAFVLSAALAGLAGALYAHYVGFVSPESfSFLLSIEILLMVVL------GGLGSLL 233

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446997392 266 GTFIGVLIIGVLNNGLNLLGvssFFQQVVKGLVILLAVL 304
Cdd:COG4177  234 GPVLGAVLLVLLPELLRSLP---EYRLLIFGLLLILVVL 269
TM_PBP1_LivM_like cd06581
Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two ...
 44-304 1.79e-14

Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.


Pssm-ID: 119323 [Multi-domain]  Cd Length: 268  Bit Score: 72.09  E-value: 1.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  44 VSINALIAFGMTFVILTGGIdLSVG-SILALSSALVAGMMAS--GMDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPF-I 119
Cdd:cd06581    1 ILIYAILALGLNLLLGYAGQ-LSLGhAAFFGIGAYTAALLATrlGLPFWLALLAAGLVAALVGLLLGLPALRLRGVYFaI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 120 ATLATMTIFRGLTLVYMDgrpITG------LGDHLMFQMFGRGYFLGIPVPAVTMMIAFAVLYFILKKTTFGRRTFAIGG 193
Cdd:cd06581   80 ATLAFAEIVRLLALNWSS---LTGgsnglsGIPPPLLGGLLLSSPLAFYYLVLAVLLLVLLLLRRLVRSPFGRALRAIRE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 194 NEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTA-GTSYELDAIAAVVLggtslsGGRGWIVGTFIGVL 272
Cdd:cd06581  157 NEVAAEALGINVTRYKLLAFALSAALAGLAGALYAHYLGFVSPESfGFALSIELLLMVVL------GGLGSLLGPVLGAA 230

                        250       260       270
                 ....*....|....*....|....*....|..
gi 446997392 273 IIGVLNNGLNLLGVSsfFQQVVKGLVILLAVL 304
Cdd:cd06581  231 LLVLLPELLRSLGPG--LRLLVFGLLLILVVL 260
COG4120 COG4120
ABC-type uncharacterized transport system, permease component [General function prediction ...
 64-272 5.09e-13

ABC-type uncharacterized transport system, permease component [General function prediction only];


Pssm-ID: 443296  Cd Length: 296  Bit Score: 68.22  E-value: 5.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  64 DLSVGSILALSSALVAGMMASGMDPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTLVYMdGRP-IT 142
Cdd:COG4120   34 DLTVDGSFPLGAAVAAVLIVAGVNPFLATLAAFLAGALAGLVTGLLHTKLKIPPLLAGILTMTALYSINLRIM-GKPnIP 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 143 GLGDHLMFQMFGR----GYFLGIPVPAVTMMIAFAVLYFILkKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGI 218
Cdd:COG4120  113 LLGEDTIFTLLPDlglpGDWAKLLVLLVIVLVIKLLLDWFL-KTELGLALRATGDNPQMARALGINTDRMKILGLALSNG 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446997392 219 LAALAGIVLTSRLDSAQPTAGTSYELDAIAAVVLgGTSLSGGRGWIVGTFIGVL 272
Cdd:COG4120  192 LVALSGALVAQYQGFADVNMGIGTIVIGLASVII-GEVLFGSRSILRRLLAVVL 244
TM_PBP1_transp_TpRbsC_like cd06580
Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. ...
 67-302 3.35e-10

Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters, which are mainly involved in the uptake of branched-chain amino acids (AAs) or in the uptake of monosaccharides including ribose, galactose, and arabinose, and which generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction.


Pssm-ID: 119322 [Multi-domain]  Cd Length: 234  Bit Score: 58.99  E-value: 3.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  67 VGSILALSSALVAGMMASGMdPFLAMAVGLLAGLVMGIINGIIIAKGKVAPFIATLATMTIFRGLTlvymdgrpitglgd 146
Cdd:cd06580   30 LGAFAAALVALYLGLPATGS-LPLGLLAAALAGALWALLPALLKAKLGVNEVISGLMLNYIALGLT-------------- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 147 hlmfqmfgrGYFLGIpvpavtMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIV 226
Cdd:cd06580   95 ---------SYLLLL------ALLLVILVWLLLYRTRFGLRLRAVGENPRAARYAGINVKRVRLLAMLISGALAGLAGAY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 227 LTSRLDSAQPTAGTS-YELDAIAAVVLGGTSlsggrgwIVGTFIGVLIIGVLNNGLNLL----GVSSFFQQVVKGLVILL 301
Cdd:cd06580  160 LVLGVQGRFTEGMSAgYGFIAIAVALLGRWN-------PLGILLAALLFGALEAGGIALqrsgGVPSELVQVLPGIIVLF 232


                 .
gi 446997392 302 A 302
Cdd:cd06580  233 V 233
NupP COG4603
ABC-type guanosine uptake system NupNOPQ, permease component NupP [Nucleotide transport and ...
 76-306 8.07e-10

ABC-type guanosine uptake system NupNOPQ, permease component NupP [Nucleotide transport and metabolism];


Pssm-ID: 443653 [Multi-domain]  Cd Length: 356  Bit Score: 58.98  E-value: 8.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392  76 ALVAGMMASGMDPFLAMAVGLLAGLVMGIINGIIIAKGKVAP------------FIATLATMTIFRGLTLVYMDGRPITG 143
Cdd:COG4603  100 AAAVGLALPGLPGPLHLPLALLAGALAGALWAAIPGLLKARFgvnevittlmlnYIALYLVNYLVRGPLRDPGSGFPQTP 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 144 -LGDHLMFQMFGRGYFLGIPVPAvtMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAAL 222
Cdd:COG4603  180 pIPESARLPRLLPGTRLHLGLLI--ALLAAVLVWVLLNRTTLGYELRAVGLNPRAARYAGINVKRLIVLAMLISGALAGL 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 223 AGIV-LTSRLDSAQPTAGTSYELDAIAAVVLGGTSlsggrgwIVGTFIGVLIIGVLNNGLNLL----GVSSFFQQVVKGL 297
Cdd:COG4603  258 AGAVeVLGVQGRLTPGFSPGYGFTGIAVALLGRNN-------PLGIILAALLFGALYVGGDAMqralGVPSEIVDVIQGL 330


                 ....*....
gi 446997392 298 VILLAVLID 306
Cdd:COG4603  331 IILFVLAAD 339
PRK10740 PRK10740
high-affinity branched-chain amino acid ABC transporter permease LivH;
166-305 2.86e-03

high-affinity branched-chain amino acid ABC transporter permease LivH;


Pssm-ID: 182689 [Multi-domain]  Cd Length: 308  Bit Score: 38.75  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 166 VTMMIAFAVLYFILKKTTFGRRTFAIGGNEEAAALSGINVTRIKVMIYGLSGILAALAGIVLTSRLDSAQPTAGTSYELD 245
Cdd:PRK10740 162 IVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMK 241

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997392 246 AIAAVVLGGTslsggrGWIVGTFIGVLIIGVlNNGLNLLGVSSFFQQVVKGLVILLAVLI 305
Cdd:PRK10740 242 AFTAAVLGGI------GSIPGAMIGGLILGI-AEALSSAYLSTEYKDVVSFALLILVLLV 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH