|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-761 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 1861.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 4 NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 83
Cdd:PRK09103 1 SLLVTKRDGRTERINLDKIHRVITWAAEGLHNVSVSQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 84 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTG 163
Cdd:PRK09103 81 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDKHLLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 164 EIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 243
Cdd:PRK09103 161 EIYESAQFLYILVAACLFSNYPKETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 244 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNR 323
Cdd:PRK09103 241 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 324 GVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMM 403
Cdd:PRK09103 321 GVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDEFERLYTKYEQDDSIRKKRVKAVELFSLMM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 404 QERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAI 483
Cdd:PRK09103 401 QERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINSLDELEELAD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 484 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 563
Cdd:PRK09103 481 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 564 ACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 643
Cdd:PRK09103 561 ACPWFNETTYAQGILPIDTYKKDLDAICNEPLHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 644 IKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYK 723
Cdd:PRK09103 641 IKASKDGILKQVVPDYERLKDAYELLWEMPNNDGYLQLVGIMQKFVDQSISANTNYDPSRFPSGKVPMKQLLKDLLTAYK 720
|
730 740 750
....*....|....*....|....*....|....*...
gi 446997908 724 FGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI 761
Cdd:PRK09103 721 FGVKTLYYHNTRDGAEDAQDDLQPSIQDDGCEGGACKI 758
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-742 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 698.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 88 HLRKKAYGQFepPALYDHVvKMVEMGKYDNHLLEdyteEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNrVTGEIYE 167
Cdd:COG0209 1 QLRKEALGQY--KSFSEKI-KYVEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 168 SAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKY 247
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKPEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDALKDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 248 VSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEG 327
Cdd:COG0209 153 SKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDER 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 328 NRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFadqEEFERLYTKYEKDDSIRKqRVKAVELFSLMMQERA 407
Cdd:COG0209 233 RRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYG---EEFEEAYEEYEADGRVYK-TIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 408 STGRIYIQNVDHCNTHSPFdPAIAPVRQSNLCLEIALPTKPLndvndengEIALCTLSAFNLGAIN-----NLDELEELA 482
Cdd:COG0209 309 ETGEPGILFKDTINRRNPL-PHLGVIHSSNLCGEIPLLPYES--------EDASCNLGSINLAKFVkdgefDWEKLEETV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 483 ILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQ 562
Cdd:COG0209 380 RTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKER 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 563 GACPWFNETTYAKGILPIDTYKKDLdtiaNEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYV 642
Cdd:COG0209 460 GAFPAFEGSKYAKGILPFDKYLDDL----LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 643 SIKASKD-GILRQVVPDY-------------------------------EHLHDAYELLWEMPgNDGYLQLVGIMQKFID 690
Cdd:COG0209 536 YVRKVLDgGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelpEELKELYVTAYEID-PEWHIDMQAARQKHVD 614
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 446997908 691 QSISANTNYDPSrfpsgkVPMQQLLKDLLTAYKFGVKTLYYqnTRDGAEDAQ 742
Cdd:COG0209 615 QAISKTLNLPND------ATVEDLAELYLLAWKLGLKGIYY--YRDGSRTGQ 658
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 669.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 145 YAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSS 224
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 225 CVLIECGDS-LDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAAT 303
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 304 LFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFadqEEFERLYTKYE 383
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYG---EEFEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 384 KDDSIRK--QRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPlndvnDENGEIAL 461
Cdd:TIGR02506 238 KDVEARKkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDD-----SHKGETAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 462 CTLSAFNLGAI-----NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSA 536
Cdd:TIGR02506 313 CNLASVNLANFvmedkFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 537 NNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTI-ANEPLHYDWEALRESIKTHGLRNST 615
Cdd:TIGR02506 393 RDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKtSMAPTEEDWEALRERIKEYGLRNSQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 616 LSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQV--------------------------------VPDYEHLH 663
Cdd:TIGR02506 473 LTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPnkylmkeleelglwdadrrgdivenvgspqpiAAIPETLK 552
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446997908 664 DAYELLWEMPgNDGYLQLVGIMQKFIDQSISANTNYDPsrfpsgKVPMQQLLKDLLTAYKFGVKTLYYQNTR 735
Cdd:TIGR02506 553 YKYKTAYELD-QEALIDMAADRQKFVDQSISLNLFLTE------EVTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
223-731 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 552.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 223 SSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAA 302
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 303 TLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFfadQEEFERLYTKY 382
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLY---GEEFEKEYYER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 383 EKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFdPAIAPVRQSNLCLEIALPTKPlndvndenGEIALC 462
Cdd:pfam02867 158 EENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQ-KHLGTIKSSNLCTEIVQPTSP--------SEIAVC 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 463 TLSAFNLGAI------NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSA 536
Cdd:pfam02867 229 NLASINLAKFvefggtFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 537 NNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTL 616
Cdd:pfam02867 309 RDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQL 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 617 SALMPSETSSQISNATNGIEPPRGYVSIKASKDgilrqvvpdyEHLHDAYELLWEMPgNDGYLQLVGIMQKFIDQSISAN 696
Cdd:pfam02867 389 TAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------EETKEYYKTAYDID-QKAHIDMAAARQPFVDQSISKT 457
|
490 500 510
....*....|....*....|....*....|....*
gi 446997908 697 TNYDpsrfpsGKVPMQQLLKDLLTAYKFGVKTLYY 731
Cdd:pfam02867 458 LFLP------NDATTSDLKSLYLYAWKLGLKTIYY 486
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
169-734 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 532.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 169 AQFLYILVAACLFSNypretRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYV 248
Cdd:cd01679 1 PQDRLMRVALGLASG-----DLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 249 SQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGN 328
Cdd:cd01679 76 KIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 329 RVRHMDYGVQINKLMYTRLLKgeditlfspsdvpglydaffadqeeferlytkyekddsirkqrvkavELFSLMMQERAS 408
Cdd:cd01679 156 RARDLFYGVWIPDLFMERVER-----------------------------------------------DLWRKILESQFE 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 409 TGRIYIQNVDHCNTHSPFDpAIAPVRQSNLCLEIALPTKPLndvNDENGEIALCTLSAFNLGAINNLDELEELAILAVRA 488
Cdd:cd01679 189 TGYPYILFKDTCNRKNPQK-HLGTIKSSNLCTEILQPTSPS---EDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 489 LDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGacpwf 568
Cdd:cd01679 265 LDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 569 nettyakgilpidtykkdldtianeplhydwealresikthGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASK 648
Cdd:cd01679 340 -----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVL 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 649 DGILRQVVPDYEHLHDAYELL---WEMpGNDGYLQLVGIMQKFIDQSISANTNYDPSrfpsgkVPMQQLLKDLLTAYKFG 725
Cdd:cd01679 379 SGEFPVVNPHLEKDLWEYGLYktaYEI-DQRWLIDLAADRQKHIDQGQSLNLFLTPP------ATTRDLNSLYFYAWKKG 451
|
....*....
gi 446997908 726 VKTLYYQNT 734
Cdd:cd01679 452 LKTLYYLRT 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-761 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 1861.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 4 NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 83
Cdd:PRK09103 1 SLLVTKRDGRTERINLDKIHRVITWAAEGLHNVSVSQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 84 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTG 163
Cdd:PRK09103 81 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDKHLLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 164 EIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 243
Cdd:PRK09103 161 EIYESAQFLYILVAACLFSNYPKETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 244 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNR 323
Cdd:PRK09103 241 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 324 GVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMM 403
Cdd:PRK09103 321 GVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDEFERLYTKYEQDDSIRKKRVKAVELFSLMM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 404 QERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAI 483
Cdd:PRK09103 401 QERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINSLDELEELAD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 484 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 563
Cdd:PRK09103 481 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 564 ACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 643
Cdd:PRK09103 561 ACPWFNETTYAQGILPIDTYKKDLDAICNEPLHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 644 IKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYK 723
Cdd:PRK09103 641 IKASKDGILKQVVPDYERLKDAYELLWEMPNNDGYLQLVGIMQKFVDQSISANTNYDPSRFPSGKVPMKQLLKDLLTAYK 720
|
730 740 750
....*....|....*....|....*....|....*...
gi 446997908 724 FGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI 761
Cdd:PRK09103 721 FGVKTLYYHNTRDGAEDAQDDLQPSIQDDGCEGGACKI 758
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
2-761 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 1278.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 2 NQNLLVTKRDGSTERINLDKIHRVLDWAAEGlHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLA 81
Cdd:PHA02572 1 SMIINVIKSSGVSQPFDLEKIHKVLEWACEG-TGVDPSELEENSKIQLRDGMTTKDIQEILIKSAADLISVEEPDYQYVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 82 ARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRV 161
Cdd:PHA02572 80 ARLLMFALRKQVYGQFEPPSFIDHISKCVNEGKYDPEILSKYSAEEITYLESFIDHDRDFEFTYAGAMQLKEKYLVQDRS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 162 TGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATS 241
Cdd:PHA02572 160 TGEIYETPQFAYMLIAMALHQDEPKEDRLEHVIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIESGDSLDSINKTA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 242 SAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKN 321
Cdd:PHA02572 240 MAIVKYISKRAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 322 NRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPG-LYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFS 400
Cdd:PHA02572 320 NKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGeLYDAYFADQDRFRELYEALEKDPSVRKKRIKAQELFL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 401 LMMQERASTGRIYIQNVDHCNTHSPFdpaIAPVRQSNLCLEIALPTKPLNDVnDENGEIALCTLSAFNLGAINNLDELEE 480
Cdd:PHA02572 400 LLLKERSETGRIYIMFIDHCNNHSPF---KDPIRQSNLCCEIALPTKPLNHI-DGEGEIALCTLSAIVLGNFEDQDEIEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 481 LAILAVRALDALLDYQDYPIPAAKRgAMGRRTLGIGVINFAYYLAKHGKRYSDgSANNLTHKTFEAIQYYLLKASNELAK 560
Cdd:PHA02572 476 LAEVAVRALDNLLDYQDYPVPAALK-AKKRRSLGVGVTNYAHYLAKNFASYED-ANADLVHELFERLQYYLIKASNKLAK 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 561 EQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRG 640
Cdd:PHA02572 554 EKGACEYFSDTKYSRGELPIDWYKKKVDELVAPKYNCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRG 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 641 YVSIKASKDGILRQVVPDYEHLHDAYELLWEM--PGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDL 718
Cdd:PHA02572 634 PVSIKKSKEGPFNQVVPNVETLKDLYDLLWDLakKGNKGYLTQVAIMQKFVDQAISANTSYDPENYPNGKVPMSVMLDDL 713
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 446997908 719 LTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDgCESgaCKI 761
Cdd:PHA02572 714 LYFYYYGGKTLYYHNTRDGKGTEDYEIETPKAED-CDS--CKL 753
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-742 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 698.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 88 HLRKKAYGQFepPALYDHVvKMVEMGKYDNHLLEdyteEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNrVTGEIYE 167
Cdd:COG0209 1 QLRKEALGQY--KSFSEKI-KYVEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 168 SAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKY 247
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKPEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDALKDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 248 VSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEG 327
Cdd:COG0209 153 SKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDER 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 328 NRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFadqEEFERLYTKYEKDDSIRKqRVKAVELFSLMMQERA 407
Cdd:COG0209 233 RRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYG---EEFEEAYEEYEADGRVYK-TIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 408 STGRIYIQNVDHCNTHSPFdPAIAPVRQSNLCLEIALPTKPLndvndengEIALCTLSAFNLGAIN-----NLDELEELA 482
Cdd:COG0209 309 ETGEPGILFKDTINRRNPL-PHLGVIHSSNLCGEIPLLPYES--------EDASCNLGSINLAKFVkdgefDWEKLEETV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 483 ILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQ 562
Cdd:COG0209 380 RTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKER 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 563 GACPWFNETTYAKGILPIDTYKKDLdtiaNEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYV 642
Cdd:COG0209 460 GAFPAFEGSKYAKGILPFDKYLDDL----LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 643 SIKASKD-GILRQVVPDY-------------------------------EHLHDAYELLWEMPgNDGYLQLVGIMQKFID 690
Cdd:COG0209 536 YVRKVLDgGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelpEELKELYVTAYEID-PEWHIDMQAARQKHVD 614
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 446997908 691 QSISANTNYDPSrfpsgkVPMQQLLKDLLTAYKFGVKTLYYqnTRDGAEDAQ 742
Cdd:COG0209 615 QAISKTLNLPND------ATVEDLAELYLLAWKLGLKGIYY--YRDGSRTGQ 658
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 669.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 145 YAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSS 224
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 225 CVLIECGDS-LDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAAT 303
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 304 LFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFadqEEFERLYTKYE 383
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYG---EEFEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 384 KDDSIRK--QRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPlndvnDENGEIAL 461
Cdd:TIGR02506 238 KDVEARKkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDD-----SHKGETAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 462 CTLSAFNLGAI-----NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSA 536
Cdd:TIGR02506 313 CNLASVNLANFvmedkFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 537 NNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTI-ANEPLHYDWEALRESIKTHGLRNST 615
Cdd:TIGR02506 393 RDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKtSMAPTEEDWEALRERIKEYGLRNSQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 616 LSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQV--------------------------------VPDYEHLH 663
Cdd:TIGR02506 473 LTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPnkylmkeleelglwdadrrgdivenvgspqpiAAIPETLK 552
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446997908 664 DAYELLWEMPgNDGYLQLVGIMQKFIDQSISANTNYDPsrfpsgKVPMQQLLKDLLTAYKFGVKTLYYQNTR 735
Cdd:TIGR02506 553 YKYKTAYELD-QEALIDMAADRQKFVDQSISLNLFLTE------EVTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
223-731 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 552.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 223 SSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAA 302
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 303 TLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFfadQEEFERLYTKY 382
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLY---GEEFEKEYYER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 383 EKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFdPAIAPVRQSNLCLEIALPTKPlndvndenGEIALC 462
Cdd:pfam02867 158 EENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQ-KHLGTIKSSNLCTEIVQPTSP--------SEIAVC 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 463 TLSAFNLGAI------NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSA 536
Cdd:pfam02867 229 NLASINLAKFvefggtFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 537 NNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTL 616
Cdd:pfam02867 309 RDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQL 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 617 SALMPSETSSQISNATNGIEPPRGYVSIKASKDgilrqvvpdyEHLHDAYELLWEMPgNDGYLQLVGIMQKFIDQSISAN 696
Cdd:pfam02867 389 TAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------EETKEYYKTAYDID-QKAHIDMAAARQPFVDQSISKT 457
|
490 500 510
....*....|....*....|....*....|....*
gi 446997908 697 TNYDpsrfpsGKVPMQQLLKDLLTAYKFGVKTLYY 731
Cdd:pfam02867 458 LFLP------NDATTSDLKSLYLYAWKLGLKTIYY 486
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
169-734 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 532.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 169 AQFLYILVAACLFSNypretRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYV 248
Cdd:cd01679 1 PQDRLMRVALGLASG-----DLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 249 SQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGN 328
Cdd:cd01679 76 KIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 329 RVRHMDYGVQINKLMYTRLLKgeditlfspsdvpglydaffadqeeferlytkyekddsirkqrvkavELFSLMMQERAS 408
Cdd:cd01679 156 RARDLFYGVWIPDLFMERVER-----------------------------------------------DLWRKILESQFE 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 409 TGRIYIQNVDHCNTHSPFDpAIAPVRQSNLCLEIALPTKPLndvNDENGEIALCTLSAFNLGAINNLDELEELAILAVRA 488
Cdd:cd01679 189 TGYPYILFKDTCNRKNPQK-HLGTIKSSNLCTEILQPTSPS---EDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 489 LDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGacpwf 568
Cdd:cd01679 265 LDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 569 nettyakgilpidtykkdldtianeplhydwealresikthGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASK 648
Cdd:cd01679 340 -----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVL 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 649 DGILRQVVPDYEHLHDAYELL---WEMpGNDGYLQLVGIMQKFIDQSISANTNYDPSrfpsgkVPMQQLLKDLLTAYKFG 725
Cdd:cd01679 379 SGEFPVVNPHLEKDLWEYGLYktaYEI-DQRWLIDLAADRQKHIDQGQSLNLFLTPP------ATTRDLNSLYFYAWKKG 451
|
....*....
gi 446997908 726 VKTLYYQNT 734
Cdd:cd01679 452 LKTLYYLRT 460
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-756 |
1.07e-113 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 361.82 E-value: 1.07e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 4 NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADL------------IS 71
Cdd:PRK07088 2 NIKIKKRDGQYEPLQVEKTKKMVKLACEGLYGCDPLELELDSRIQFRDGMTTKEIQKSLIQTAIEKviqnskdnngnnTK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 72 RDAPDYQYLAARLAIFHLRKKA-----YGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYA 146
Cdd:PRK07088 82 KTNPNWQYVAARLYVFDLYKEArinrhYNSFGYGDYYELVKKLVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFLFNYE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 147 AVKQLEGKYLVQNrVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCV 226
Cdd:PRK07088 162 GLKLLADRYLVKG-FNREILELPQERFMGIAMHLAIPEGKEKRVYYAKKFYDLLSELKATVATPTLSNAGTPFYQLSSCF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 227 LIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFY 306
Cdd:PRK07088 241 ISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 307 PMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGL----YDAFFADQE--EFERLYT 380
Cdd:PRK07088 321 DIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKKVkgysLEDYYDEEDrkEFTKKYL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 381 KYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAiAPVRQSNLCLEIALPTKPLN----DVNDEN 456
Cdd:PRK07088 401 ECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHK-GMIYSSNLCHEIAQNMSESElleeEIIDEN 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 457 GEIAL-----------CTLSAFNLGAINNlDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLA 525
Cdd:PRK07088 480 GYYEVvqkikagdmvtCNLNSIVLGNVDD-EELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGTSGYHHMLA 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 526 KHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGilpidTYKKDLDTiaNEPlhyDWEALRES 605
Cdd:PRK07088 559 NNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG-----KYFERRGY--NSE---RWKKLKEE 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 606 IKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPD-----YEHLHDAYEL--LWEMPGNdgy 678
Cdd:PRK07088 629 IKKYGMRNGYITAVAPTGSTSNIANTTAGIDPVFKRFFMEEKKGSFTPKTAPDlneenFWYYKEAHTIdqQWSIKAC--- 705
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446997908 679 lqlvGIMQKFIDQSISANTNYDPSrfpsgkVPMQQLLKDLLTAYKFGVKTLYYQNTRdgaedaqddlvpSIQDDGCES 756
Cdd:PRK07088 706 ----GVRQRHIDQAQSFNLYITPE------YKAKQILNLYIEAWKQGVKTIYYVRNK------------SLEMDECTS 761
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-755 |
1.16e-108 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 349.41 E-value: 1.16e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARL 84
Cdd:PRK08447 2 ITVVKRNGRIEPLDISKIQKYTSDAVEGLEGVSQSELEVDAKIQFRDGITTEEIQQTLIKTAVDKIDIDRPNWTFVAARL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 85 AIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEfkqMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRvTGE 164
Cdd:PRK08447 82 FLYDLYHKVSGFTGYNHLKEYFEKGEKEGRILLGLKEKYDLDD---LNAYIKPERDLQFNYLGIKTLYDRYLIKDR-NNN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 165 IYESAQFLYILVAACLFSNyprETRLQ-YVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 243
Cdd:PRK08447 158 PIELPQHMFMAIAMFLAQN---ELDPQkWAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYKE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 244 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNR 323
Cdd:PRK08447 235 MALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAIAVYLEPWHMDISDFIDLRKNS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 324 GVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFfadQEEFERLYTKYEKDDSIRKQRVKAVELFSLMM 403
Cdd:PRK08447 315 GEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELY---GEEFEKRYLEYEKDEKIIKEYINAKELWKKIL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 404 QERASTGRIYIQNVDHCNTHSPFDPAiAPVRQSNLCLEIALPTKP----------------------------------- 448
Cdd:PRK08447 392 TNYFETGLPFLCFKDNANRANPNAHA-GIIRSSNLCTEIFQNTAPnhykikiefedgsieffeeeelvtvdsgitkkakk 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 449 ---LNDVNDE----------NGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGI 515
Cdd:PRK08447 471 itsLDSLKGKkiyivekekkDGKTAVCNLASINLSKINTKEDIERVVPIAIRMLDNVIDLNFYPNRKVKATNLKSRAIGL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 516 GVINFAYYLAKHGKRYsdGSANNLTH--KTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANE 593
Cdd:PRK08447 551 GVMGEAQMLAEHKIAW--GSKEHLEKidEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPIDKANEEAKKLVER 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 594 ----PLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPD-----YEHLHD 664
Cdd:PRK08447 629 gglfDSACDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEENLSGLIPVVVPNlspetWQYYTP 708
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 665 AYELlwempgndGYLQLV---GIMQKFIDQSISANT--NYDPSrfpSGKVpmqqlLKDLLT-AYKFGVKTLYYqnTRDGA 738
Cdd:PRK08447 709 AYDL--------DQKDLIkaaAVRQKWIDQGQSLNIflSLDKA---SGKY-----LNEIYTlAWKLGLKSTYY--LRSES 770
|
810
....*....|....*....
gi 446997908 739 EDAQDDLVP--SIQDDGCE 755
Cdd:PRK08447 771 PESEEVSVAdrSIECEGCQ 789
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
62-731 |
2.49e-97 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 320.54 E-value: 2.49e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 62 IIKAAADLISRDAPDYQYLAARLAIFHLRKK---AYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHD 138
Cdd:PRK12364 152 LIKAAVELTTQEAPDWEFIAARLLMLQFSKKlgkSLEKLGIHSFYDKIKYLTEEGLYGSYILEHYSREEIEEAAGFIDPE 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 139 RDMTFSYAAVKQLEGKYLVQNRvTGEIYESAQFLYILVAACLFSNyPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTP 218
Cdd:PRK12364 232 RDKLFTYSGLDLLLKRYVIRTH-SHEPLESPQEMFLGIALHLAMP-EKQDRMGWVKRFYDMLSKLKVTMATPTLSNARKP 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 219 TRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQ-TAVkSCSQGGV 297
Cdd:PRK12364 310 FHQLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANdTAV-AVDQLGM 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 298 RGGAATLFYPMWHLEVESLLVLKNNRGveGNRVRHMDY--GVQINKLMYtRLLKgEDIT----LFSPSDVPGLYDAFFAD 371
Cdd:PRK12364 389 RQGAVAVYLDVWHKDIPEFLQLRTNNG--DDRMKAHDVfpAVCYPDLFW-KMVR-DDINqswyLFCPHEILTVKGYALED 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 372 --QEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPAIAPVRQSNLCLEIALPTKPL 449
Cdd:PRK12364 465 yyGEEWEKRYLDCVNDARISKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANP-NKHKGMIYCSNLCTEIAQNMSAI 543
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 450 NDVN----DENGE-----------IALCTLSAFNLGAI--NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRT 512
Cdd:PRK12364 544 ETVSteieTEDGDtvvvtttrpgdFVVCNLASLSLGNIdlEDEEELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRS 623
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 513 LGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGilpidTYKKDLDTIAN 592
Cdd:PRK12364 624 IGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTG-----AYFRKRGYTSE 698
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 593 EplhydWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPD--------YEHLHD 664
Cdd:PRK12364 699 E-----WQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDPVMKRYFLEEKKGALMPRVAPElsdktfwlYKNAHL 773
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446997908 665 AyELLWEMpgndgylQLVGIMQKFIDQSISANTnYDPSRFpsgkvPMQQLLKDLLTAYKFGVKTLYY 731
Cdd:PRK12364 774 I-DQKWSI-------RAAGVRQRHIDQAQSVNL-YITNEF-----TMRQVLDLYLLAWEEGVKTIYY 826
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
18-737 |
1.04e-93 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 308.96 E-value: 1.04e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 18 NLDKIHRVLDWAAEGLHNVSISQVElRSHIQFYDGIKT---SDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKA- 93
Cdd:PRK09209 23 DKERLDRYIDQIHAEFPQLDVEDYK-RRVFNFVERKESvtaDDLVDYLIREAEARVDLEEPEWTFFAARLYLNRLYKRAs 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 94 ----------YGQFeppalYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVtG 163
Cdd:PRK09209 102 rnrfydasekYGSF-----VGLQESLAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSD-R 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 164 EIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 243
Cdd:PRK09209 176 NVYELPQERWLTIALYLMQNEPRERRMQLVKEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIYDSNTD 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 244 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQ-TAVkSCSQGGVRGGAATLFYPMWHLEVESLLVLKNN 322
Cdd:PRK09209 256 VARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNnTAV-SVDQLGQRKGAIAVYLDVWHKDIESFLDLRLN 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 323 RGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVP-----GLYDafFADQEE----FERLYTKYEKDDSIRKQRV 393
Cdd:PRK09209 335 NGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvmgwYLED--FYDEKKgdgsFREKYEECVADERLSRKTV 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 394 KAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPAIAPVRQSNLCLEIAL---PTKPLNDVNDEN--------GEIALC 462
Cdd:PRK09209 413 KAIDIMKRIMVSQLETGNPFMFYRDEVNRMNP-NKHEGMIYSSNLCTEIMQnmsPTVMIQEIISGGqivitkqpGDFVVC 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 463 TLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHK 542
Cdd:PRK09209 492 NLSSINLGRAVTADVLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADE 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 543 TFEAIQYYLLKASNELAKEQGACPWFNETTYAKGilpidTY--KKDLDTianeplhYDWEALRESIKTHGLRNSTLSALM 620
Cdd:PRK09209 572 LYERINYLTIQASMELAKEKGAYPVFKGSDWQTG-----EYfeRRGYNS-------PQWDELAAQVAENGVRNAYLMAVA 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 621 PSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEH------LHDAYEL--LWEMPGNdgylqlvGIMQKFIDQS 692
Cdd:PRK09209 640 PNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVTAPDLSLdtwpyyEKGAYKVdqFWSIRQN-------AARQRHVDQS 712
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 446997908 693 ISANTnYDPSrfpsgKVPMQQLLKDLLTAYKFGVKTLYYQNTRDG 737
Cdd:PRK09209 713 ISFNF-YVPS-----TIRASELLDLHMTAWKEGLKTTYYVRSTDI 751
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-731 |
1.04e-89 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 304.18 E-value: 1.04e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 7 VTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVEL-RSHIQFYDGIKTSDIHETIIKAAADLISRDaPDYQYLAARLA 85
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRFPETTDAALLAdMAFANFYSGIKESEVVLACIMAARANIEKE-PDYAFVAAELL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 86 IFHLRKKAYGQfeppALYDHVVKMVEMGKYDNHLLEDYT---EEEFKQMD-----TFIDHDRDMTFSYAAVKQLEGKYLv 157
Cdd:PRK12365 317 LDVVYKEALGK----SKYDEDLEEAHKDHFKRYILEGDTyrlNPELKHYDldalaEALDLSRDLQFSYMGVQNLYDRYF- 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 158 qNRVTGEIYESAQFLYILVAACLFSNyPRETRLQYVKRFYDAVSTFKISLPTPIM--SGVRTptRQFSSCVLIECGDSLd 235
Cdd:PRK12365 392 -NHHEGRRLETPQIFWMRVSMGLALN-EGQDKTSWAITFYNLLSTFRYTPATPTLfnSGMRH--SQLSSCYLSTVQDDL- 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 236 sinatsSAIVKYVSQRA-------GIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPM 308
Cdd:PRK12365 467 ------VHIYKVISDNAmlskwagGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVCVYLEV 540
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 309 WHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFfadQEEFERLYTKYE-KDDS 387
Cdd:PRK12365 541 WHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAY---GEEFEKLYEEYErKVDT 617
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 388 --IR-KQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAiAPVRQSNLCLEIALptkplndvNDENGEIALCTL 464
Cdd:PRK12365 618 geIRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHK-GVVRCSNLCTEILL--------NCSETETAVCNL 688
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 465 SAFNL-GAINN--LDE--LEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNL 539
Cdd:PRK12365 689 GSINLvEHIVNdgLDEekLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEF 768
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 540 THKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDT------YKKDLDTIANEPLHYDWEALRESIKTHGLRN 613
Cdd:PRK12365 769 ADYSSELIAYYAILASSLLAKERGTYSSYKGSKWDRGYLPIDTiellkeYRGEANLLMDTSSRKDWEPVRSLIKEYGMRN 848
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 614 STLSALMPSETSSQISNATNGIEP-----------------PRGYVSIKASK---------------DGILRQV--VPDy 659
Cdd:PRK12365 849 SQLMAIAPTATISNIIGVTQSIEPtykhlfvksnlsgeftiPNVYLIEKLKKlgiwdadmlddlkyfDGSLLEIerIPD- 927
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446997908 660 eHLHDAYELLWEMPgNDGYLQLVGIMQKFIDQSISANTNYDPsrfPSGKvpmqQLLKDLLTAYKFGVKTLYY 731
Cdd:PRK12365 928 -HLKKIFLTAFEIE-PEWIIECASRRQKWIDMGQSLNLYLAE---PDGK----KLSNMYLTAWKKGLKTTYY 990
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
7-741 |
2.53e-87 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 292.80 E-value: 2.53e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 7 VTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHI--QFYDGIKTSDIHETIIKAAADLISRDaPDYQYLAARL 84
Cdd:PLN02437 3 VVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVcaGVYKGVTTSQLDELAAETAAAMTTNH-PDYAILAARI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 85 AIFHLRKKAYGQFEPP--ALYDHVVKmvEMGKYDNHLLEDYTE---EEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVqn 159
Cdd:PLN02437 82 AVSNLHKNTKKSFSETvkDMYNHVNE--RSGLKAPLIADDVYDiimKNAARLDSEIIYDRDFDYDYFGFKTLERSYLL-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 160 RVTGEIYESAQFLYILVAACLfsnypRETRLQYVKRFYDAVST--FKISLPTPIMSGvrTPTRQFSSCVLIeC--GDSLD 235
Cdd:PLN02437 158 KVNGKVVERPQHMLMRVSVGI-----HKDDIESAIKTYHLMSQrwFTHASPTLFNAG--TPRPQLSSCFLI-CmkDDSIE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 236 SINAT---SSAIVKYVsqrAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLFYPMWHL 311
Cdd:PLN02437 230 GIYDTlkeCAVISKSA---GGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 312 EVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFfadQEEFERLYTKYEKDDSIRKQ 391
Cdd:PLN02437 307 DIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCW---GEEFERLYTKYEREGKAKKV 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 392 rVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPAIAPVRQSNLCLEIALPTKPlndvndenGEIALCTLSAFNL-- 469
Cdd:PLN02437 384 -VQAQQLWFAILESQIETGTPYMLFKDSCNRKSN-QQNLGTIKSSNLCTEIIEYTSP--------TETAVCNLASIALpr 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 470 --------------------GAIN---NLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAK 526
Cdd:PLN02437 454 fvrekgvpleshpsklvgslGSKNryfDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFIL 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 527 HGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDldtianEPLHYDWEALRESI 606
Cdd:PLN02437 534 LGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVT------PSGRWDWAALREMI 607
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 607 KTHGLRNSTLSALMPSETSSQISNATNGIEPprgYVSIKASKDGILRQVVPDYEHL-HDAYEL-LW------EMPGNDGY 678
Cdd:PLN02437 608 SKNGVRNSLLVAPMPTASTSQILGNNECFEP---YTSNIYSRRVLSGEFVVVNKHLlHDLTEMgLWtptlknKIIAENGS 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 679 LQLVG---------------IMQK-----------FIDQSISANTNYD-PSrfpSGKvpmqqllkdlLT-----AYKFGV 726
Cdd:PLN02437 685 VQKIPeipddlkaiyktvweIKQRtlvdmaadrgcYIDQSQSLNIHMDqPN---FGK----------LTslhfyAWSKGL 751
|
810
....*....|....*.
gi 446997908 727 KT-LYYQNTRdGAEDA 741
Cdd:PLN02437 752 KTgMYYLRSR-AAADA 766
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-735 |
1.56e-86 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 293.79 E-value: 1.56e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDaPDYQYLAARL 84
Cdd:PRK07207 149 LNVTLDDGVRRPLDMARLRALIEEACEGLEAVDAEPILAETLKNLYDGVPMDEVYKALILAARTLIEKE-PNYSYVTARL 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 85 AIFHLRKKAYGQFEPPALYDHVvkmvEMGKYDNHLLEDYTE---------EEFKQMD-----TFIDHDRDMTFSYAAVKQ 150
Cdd:PRK07207 228 LLDTLRREALGFLGVPEEVTQA----EMATRYAEYFPAFIKkgieaelldPKLAQFDlerlgAALDPERDLQFTYLGLQT 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 151 LEGKYLVqnRVTGEIYESAQFLYILVAACLFSNYP-RETRlqyVKRFYDAVSTFKI--SLPTPIMSGVRTPtrQFSSCVL 227
Cdd:PRK07207 304 LYDRYFL--HVDGTRIELPQAFFMRVAMGLALNEIdREAR---AIEFYNLLSSFDFmsSTPTLFNSGTLRP--QLSSCYL 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 228 IECGDSLDSI------NATSSaivKYVsqrAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQ-TAVkSCSQGGVRGG 300
Cdd:PRK07207 377 TTVPDDLDGIyeaikdNALLS---KFA---GGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNdTAV-AVNQGGKRKG 449
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 301 AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFfadQEEFERLYT 380
Cdd:PRK07207 450 AVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLF---GKAFEEAYT 526
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 381 KYE-KDDS--IRK-QRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPAIAPVRQSNLCLEIALPTkplndvNDEn 456
Cdd:PRK07207 527 AYEaKAARgeIKLfKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSP-QQHVGVVHSSNLCTEITLNT------SDD- 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 457 gEIALCTLSAFNL------GAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKR 530
Cdd:PRK07207 599 -EIAVCNLGSVNLvahikdGAKLDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIP 677
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 531 YSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKK---------DLDTiaNEPLhyDWEA 601
Cdd:PRK07207 678 YASDEAVEFADRSMEAVSYYAIWASTELAEERGRYSSYEGSLWSRGILPIDSLKLlaearggylEVDR--SSTL--DWDA 753
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 602 LRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILrQVVPDYeHLHDAYEL-LWE--MPGN--- 675
Cdd:PRK07207 754 LRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTYQNLYVKSNLSGEF-TVVNPY-LVRDLKARgLWDevMVNDlky 831
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 676 -DGYLQ-----------------------LVGIM---QKFIDQSISANTnYDPSrfPSGKvPMQQLLKdllTAYKFGVKT 728
Cdd:PRK07207 832 fDGSLQridripadlkalyatafevdprwLVEAAsrrQKWIDQAQSLNL-YMAG--ASGK-KLDETYK---LAWLRGLKT 904
|
....*..
gi 446997908 729 LYYQNTR 735
Cdd:PRK07207 905 TYYLRTL 911
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
193-730 |
6.20e-84 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 272.10 E-value: 6.20e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 193 VKRFYDAVSTFKISLPTPimsgvrtpTRQFSSCVLIECGDSLD---------------SINATSSAIVKYVSQR--AGIG 255
Cdd:cd00576 1 AERIYEAVKSGVITVGRP--------DLPFTGCVLVDYGDSLDpgikgvnetaksineAIQKTYQIIALAASNQngGGVS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 256 INA--GRIRALGSPIRG-GEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLE-----VESLLVLKNNRGVEG 327
Cdd:cd00576 73 FARasSILSPYGSRDYAkGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKGkgdkiSQEFLNLALANGGEG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 328 NRVRHMDYGVQINKLMYTRLlkgeditlfspsdvpglydaffadqeeferlytkyekddsirkqrVKAVELFSLMMQERA 407
Cdd:cd00576 153 IPLNFPNLSVRVSSDKPGIL---------------------------------------------VKAVELKQLIAEEAR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 408 STGRIYIQNVDHCNtHSPFDPAIApvrqsnlcleialptkplndvndengeialcTLSAFNLGAINNLDELEELAILAVR 487
Cdd:cd00576 188 KTGSPGIFNDELCN-LVSLNLARI-------------------------------MEKAINGSMDVVLEELEELAFLAVR 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 488 ALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYS-DGSANNLTHKTFEAIQYYLLKASNElakeqgacp 566
Cdd:cd00576 236 ALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGLEKVgDPEADDLAAELVDQLKKHLVKATNE--------- 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 567 wfnettyakgilpidtykkdldtianeplhydwealresikthgLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIka 646
Cdd:cd00576 307 --------------------------------------------RGFNFLLGLSPSESNSSGAPATNGVSPSRG*IAI-- 340
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 647 skdgilrqvvpdyehlhdayeLLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFpsgkvPMQQLLKDLLTAYKFGV 726
Cdd:cd00576 341 ---------------------VLNGDIGPEESLASVAILQFYADNGISDTITIPDSAT-----NLDQLLAVIDGAAAIKT 394
|
....
gi 446997908 727 KTLY 730
Cdd:cd00576 395 THVR 398
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-731 |
1.53e-76 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 263.71 E-value: 1.53e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 5 LLVTKRDGSTERINLDKIHRVLDWAAEGL-HNVS-ISQVELRSHIQFYDGIKTSDIHETIIKAAADLIsRDAPDYQYLAA 82
Cdd:PRK06539 3 ITVVKRDGSKEPYDANKVNAAIEDAARGLdDAITwVTQLASELEITLFDGITTQQLDEAVIQVALQNV-KDDPAFDTVAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 83 RLAIFHLRKKAYGQFEPPA-LYD----HVVKMVEMGKYDNHLLEDYTEE-EFKQMDTFIDHDRDMTFSYAAVKQLEGKYL 156
Cdd:PRK06539 82 RLLLKKIYKRVLGDYDSPEeLQDlhanHFRRTIEKGVAEGLLDSRLGGLfDLERLAAALDPTRDELLKYIGVVTLNNRYG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 157 VQNRvTGEIYESAQFLYILVAACLFSNY--PRETRLqyvkRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSL 234
Cdd:PRK06539 162 IRAR-NGDALEVPQYFWMRIAMGLSLNEddPTSSAL----AFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQDDI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 235 DSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVE 314
Cdd:PRK06539 237 EHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 315 SLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADqeeFERLYTKY----EKDDSIRK 390
Cdd:PRK06539 317 EFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKA---FSKRYAQYveqaEAGRIRMF 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 391 QRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSpFDPAIAPVRQSNLCLEIALPtkplndvNDENgEIALCTLSAFNL- 469
Cdd:PRK06539 394 KRITAREQFRAILMSLQTTSHPWLTWKDTINNRA-LNNNTGTIHLSNLCTEICLP-------QDRD-NVSVCNLASINLs 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 470 ----GAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFE 545
Cdd:PRK06539 465 rhlaDGELDWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIME 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 546 AIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYK-----KDLDTIANEPLHYDWEALRESIKThGLRNSTLSALM 620
Cdd:PRK06539 545 HISYAAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIAlleadRGVPVDVNRTTRLDWDALRAKVRG-GMRNATLMAIA 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 621 PSETSSQISNATNGIEPPRGYVSIKASKDG----ILRQVVPDYEHLHdayelLWE------------------MPGN--- 675
Cdd:PRK06539 624 PTASIGLVAGTTPGLDPQFSQIFSRSTSSGkfleVNRNLVADLKELG-----LWEtvreeilrsqgdiqeiaaIPDEika 698
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446997908 676 ----------DGYLQLVGIMQKFIDQSISANTnYDPSRfpsgkvPMQQLLKDLLTAYKFGVKTLYY 731
Cdd:PRK06539 699 lyrtsfqlspYAFLEVAARAQKWVDQAISRNM-YLESR------DIGDMMDIYTAAWEMGVKTTYY 757
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
150-742 |
1.37e-52 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 192.15 E-value: 1.37e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 150 QLEGKYLVQNRvTGEIYESAQFLYILVAACLFSN---YPRETRLQYVKRFYDAVSTFKISLPTPIMSGV-RTPTRQFSSC 225
Cdd:TIGR02504 1 VLAARYLLKDE-DGNIIESPEDLFRRVARALAAAedkYNSPVWKQWYERFYDLMVNLGFIPNSPTLMNAgGTRLGQLSAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 226 VLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLF 305
Cdd:TIGR02504 80 FVLPVEDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 306 YPMWHLEVESLLVLKNNRGvegnRVRHMDYGVqinklmytrllkgeditlfspsdvpGLYDAFFADQEEFERLYTKYeKD 385
Cdd:TIGR02504 160 LDVWHPDIEEFIEAKAKEG----KLQNFNISV-------------------------GVTDEFMEAVENDEEYELRN-PR 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 386 DSIRKQrVKAVELFSLMMQ---ERASTGRIYIQNVdhcNTHSPFDPaIAPVRQSNLCleialptkplndvndenGEIALC 462
Cdd:TIGR02504 210 TGEYKE-VDARELWDKIVEsawKSAEPGVLFIDTI---NKWHTCPY-GGRINATNPC-----------------GEQPLL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 463 TLSAFNLGAIN---------------NLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKH 527
Cdd:TIGR02504 268 PYESCNLGSINlakfvkndfgdeasfDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKL 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 528 GKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTianeplhydweALRESIK 607
Cdd:TIGR02504 348 GIPYDSEEARELAEEVMEFIADAAYRASAELAKERGAFPLYDASKYPMGRAMGARIPSALPA-----------EIREAIR 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 608 THGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKA-SKDGILRQVVPDYEH--------------LHDAYELLWEM 672
Cdd:TIGR02504 417 KYGIRNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNvTVGGELLEVNPLVELalrelgyysdeivkYVDEKGTVEGA 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 673 PGND---------------GYLQLVGIMQKFIDQSISANTNydpsrFPSGkVPMQQLLKDLLTAYKFGVK--TLYyqntR 735
Cdd:TIGR02504 497 PGPEelpkvfvtamdispeDHVLMQAAIQPWVDSSISKTIN-----MPSD-ATVEDVKAVYLEAWKLGLKgiTVY----R 566
|
....*..
gi 446997908 736 DGAEDAQ 742
Cdd:TIGR02504 567 DGSRSSQ 573
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
194-737 |
7.43e-49 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 178.97 E-value: 7.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 194 KRFYDAVSTFKISLPTPIMSGVRTPTR-QFSSC-VLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGG 271
Cdd:cd02888 2 DEFFYLLLSQGFIPNSPTLMNAGTGELgQLSACfVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 272 EAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNnRGVEGNRVRHMDYGVqinklmytrllkge 351
Cdd:cd02888 82 GGVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKM-KEEKTVVLQNFNISV-------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 352 ditlfspsdvpGLYDAFFA--DQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQ---ERASTGRIYIQNVDHCNTHspf 426
Cdd:cd02888 147 -----------AVTDAFMEavENDEPWELRNPREPDTGKVYRTVPARELWDKIVEaawDSADPGVLFIDTINRWNPL--- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 427 dPAIAPVRQSNLCleialptkplndvndenGEIALCTLSAFNLGAIN--------------NLDELEELAILAVRALDAL 492
Cdd:cd02888 213 -PGLGRINATNPC-----------------GEQPLLPYESCNLGSINlskfvknpfggasfDFERLREAVRLAVRFLDNV 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 493 LDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETT 572
Cdd:cd02888 275 IDVNRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDASR 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 573 YAkgilpidtykkDLDTIANEplHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVsikaskdgil 652
Cdd:cd02888 355 YL-----------MLKVIVNA--KELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPIFSPE---------- 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 653 rqvvpdyEHlhdayellwempgndgyLQLVGIMQKFIDQSISANTNydpsrFPSGkVPMQQLLKDLLTAYKFGVK--TLY 730
Cdd:cd02888 412 -------DH-----------------VRMQAALQPWVDGAISKTIN-----LPND-ATVEDVEAVYLLAWKLGLKgiTVY 461
|
....*..
gi 446997908 731 yqntRDG 737
Cdd:cd02888 462 ----RDG 464
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
135-734 |
2.16e-48 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 180.54 E-value: 2.16e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 135 IDHDRDMTFSYAAVKQLEGKYLVQNrvtgeiyESAQFLYILVAaclfsNYPRETRLQYVKRFYDAVSTFKISLPTPIMSG 214
Cdd:PRK09102 13 IDRSRDAWLTEFGKATLRDRYLLEG-------ESYQDLFARIA-----EAYADIDPEHAQRFYDYMSRGWFMPATPVLSN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 215 VRT----PTrqfsSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRG-GEAfhTGCIPFYKHFQTAV 289
Cdd:PRK09102 81 GGTdrglPI----SCFLNYVEDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPIRNnGKS--SGIIPFIKVMDSLT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 290 KSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPsdvpglydaff 369
Cdd:PRK09102 155 LAISQGSLRRGSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP----------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 370 adqeeferlytkyeKDDSIRKqRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSP--FDPAIAPVRQSNLCLEIALPTK 447
Cdd:PRK09102 224 --------------KDKSVIR-TVKARDLWAKILETRIETGEPYLLFIDNVNRALPevYKDLGLKVKASNLCSEITLPTG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 448 PlnDVNDENgEIALCTLSAFNL---GAINNLDELEELAIlavRALDALLdyQDY------PIPAAKRGAMGRRTLGIGVI 518
Cdd:PRK09102 289 I--DHLGED-RTAVCCLSSLNLeyyDEWKDTDAFIEDLM---RFLDNVL--QDFidkapdEMERAKYSAMRERSVGLGVM 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 519 NFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKgilpidtykkdldtianeplhyd 598
Cdd:PRK09102 361 GFHSYLQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGECPDAAGYGVMR----------------------- 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 599 wealresikthglRNSTLSALMPSETSSQIS-NATNGIEPPRG--YVSIKAS-----KDGILRQVVPDY----------- 659
Cdd:PRK09102 418 -------------RFSTKMAIAPTASISIILgNTSPGIEPIAAnyYTHKTLKgsftvKNKYLEKLLEEKgkdtdevwssi 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 660 -------EHLHD-----------AYEL--LWempgndgYLQLVGIMQKFIDQSISANTNydpsrFPSGkVPMQQLLKDLL 719
Cdd:PRK09102 485 ltnegsvQHLDFlseeekdvfktAFEIdqRW-------IIELAADRQKYIDQAQSLNLF-----LPAN-VPKRDLNKLHF 551
|
650
....*....|....*
gi 446997908 720 TAYKFGVKTLYYQNT 734
Cdd:PRK09102 552 EAWKKGVKSLYYQRS 566
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
140-637 |
5.37e-25 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 111.18 E-value: 5.37e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 140 DMTFSYAAVKQLEGKYLVQNRvTGEIYESAQFLYILVAACLFS---NYPRETRLQYV-KRFYDAVSTFKIsLP-TPIMSG 214
Cdd:PRK08665 9 DMKLTDNALTVLEKRYLKKDE-DGKPIETPEDMFRRVARTIAAaelIYDSKADVEALaDRFYDLMTSLEF-LPnSPTLMN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 215 VRTPTRQFSSCVLIECGDSLDSINATssaiVKYVS----QRAGIGINAGRIRALGSPIR--GGEAfhTGCIPFYKHFQTA 288
Cdd:PRK08665 87 AGRELGQLSACFVLPVGDSIEEIFDA----VKHAAlihkSGGGTGFSFSRLRPKNDRVGstGGVA--SGPVSFMRVFDAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 289 VKSCSQGGVRGGAatlfypmwhlevesllvlknNRGVEgnRVRHMDygvqINKLMYTRLLKGEdITLFSPSdVpGLYDAF 368
Cdd:PRK08665 161 TEAIKQGGTRRGA--------------------NMGIL--RVDHPD----IMEFITCKEDNGE-LTNFNIS-V-AITEAF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 369 F----ADQEeferlYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPAIAPVRQSNLCleial 444
Cdd:PRK08665 212 MeaveADEE-----YDLINPRTGEVVGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNP-TPHLGEIESTNPC----- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 445 ptkplndvndenGEIALCTLSAFNLGAIN----------NLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLG 514
Cdd:PRK08665 281 ------------GEQPLLPYESCNLGSINlskmvkngdvDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIG 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 515 IGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAK-GILPIdtykkdldtiane 593
Cdd:PRK08665 349 LGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAASRELAEERGPFPNYEGSIYDKdGLGPM------------- 415
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 446997908 594 plhydwealresikthglRNSTLSALMPSETSSQISNATNGIEP 637
Cdd:PRK08665 416 ------------------RNATVTTIAPTGTISIIAGCSSGIEP 441
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
191-637 |
6.33e-22 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 101.47 E-value: 6.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 191 QYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSI-NATSSAIVKYVSQrAGIGINAGRIRALGSPIR 269
Cdd:PRK06406 218 EYINKFEEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPVPDSIEGIfNALKYTAMIHKSG-GGTGFSFSRLRPKDDIVA 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 270 GGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNrgvEGNRVRHMDYGVQINKLMYTRLLK 349
Cdd:PRK06406 297 STKGVASGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSKDS---ENKVLSNFNISVAVTDEFFDKLDN 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 350 GEDITLFSPSDvpglydaffadQEEFerlytkyekddsirkQRVKAVELFSLMMQERAST---GRIYIQNVDHCNthspf 426
Cdd:PRK06406 374 DDYYPLRNPRN-----------GKEV---------------KRIKARQVWDLIITQAWKTgdpGVIFLDEINRKN----- 422
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 427 dpaiapvrqsnlcleialPTKPLNDVNDEN--GEIALCTLSAFNLGAIN----------NLDELEELAILAVRALDALLD 494
Cdd:PRK06406 423 ------------------PVKNLGEIESTNpcGEQPLLPYESCNLGSINlskfvengkiDWDRLRETVHIATRFLDNVID 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 495 YQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACP-WFNEtty 573
Cdd:PRK06406 485 ANKFPVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPaWYGS--- 561
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446997908 574 akgilpidtykkdldtianeplhyDWEalRESIKthgLRNSTLSALMPSETSSQISNATNGIEP 637
Cdd:PRK06406 562 ------------------------EWE--KKGIK---MRNSTTTTIAPTGTISIIAGCSSSIEP 596
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
458-660 |
4.40e-19 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 92.91 E-value: 4.40e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKH 527
Cdd:PRK08332 1304 EYESCNLASINLAKFVKYDEngkpyfdWDEYAYViqkVAKYLDNAIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKL 1383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 528 GKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKdlDTIANEPlhydWEALRESIK 607
Cdd:PRK08332 1384 GIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELPVEGFYH--PEIWNLP----WDKLVEEIK 1457
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 446997908 608 THGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
Cdd:PRK08332 1458 KYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1510
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
457-742 |
2.67e-18 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 89.90 E-value: 2.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 457 GEIALCTLSAFNLGAIN------------NLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYL 524
Cdd:PRK08115 480 GEQPLAPYSVCNLAAINlanmadketktvDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHDLL 559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 525 AKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWF-----NETTYAKGILPIDTYKKDLDtianeplhydw 599
Cdd:PRK08115 560 IYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLvgqteEETAKLREAFINTGYMKKMP----------- 628
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 600 EALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPprgYVSIKASKDGIL-------RQVVPDYEHLH---DAYEL- 668
Cdd:PRK08115 629 EDIREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEP---YFSFSYYRSGRLgkfievkADIVQEYLDKHpeaDENHLp 705
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 669 LWEMPGND----GYLQLVGIMQKFIDQSISANTNYdpsrfPSGkVPMQQLLKDLLTAYKFGVK--TLYYqntrDGAEDAQ 742
Cdd:PRK08115 706 EWFISAMElkpeAHADVQCIIQRWVDSSLSKTVNA-----PKG-YTVEQVQKVYERLYRGGAKggTVYV----DGSRDAQ 775
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
143-218 |
5.54e-16 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 73.04 E-value: 5.54e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446997908 143 FSYAAVKQLEGKYLVQNRvTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTP 218
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDE-DGELLETPQDMFMRVALALAGAELEEDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
486-694 |
1.57e-14 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 77.14 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 486 VRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGAC 565
Cdd:PRK06948 338 VRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGAY 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 566 PWFNETTYAKG-----ILPIdtykkdldtianeplhydweALRESIKTHGLRNSTLSALMPSETSSQI--SNATNGIEPP 638
Cdd:PRK06948 418 PLCDPAAHLDAlragpPLPH--------------------AVCHAIARHGLRNSHLLSFAPVGSVSLAfgDNCSPGIEPA 477
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446997908 639 RGYVSIKASKDGILRqvVPDYEHLHDAYELLWEMPGN----------------DGYLQLVGIMQKFIDQSIS 694
Cdd:PRK06948 478 RAWIEHRPVRAGAGG--ARGMRAENHAYRLFRSLRGEraalpdyfvtaadvapADHLAMRAALQPYVDAGIS 547
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
5-92 |
4.68e-14 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 68.06 E-value: 4.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446997908 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLHNVS---ISQVELRSHIQFYDGIKTSDIHETIIKAAADLisrdaPDYQYLA 81
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQAdelASEVEEELEKSLEDGISTEEIQDLVEKTLAEH-----PDYAVAR 75
|
90
....*....|.
gi 446997908 82 ARLAIFHLRKK 92
Cdd:pfam03477 76 AYILYRNLRKE 86
|
|
| |
