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Conserved domains on  [gi|447007504|ref|WP_001084760|]
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MULTISPECIES: proline/glycine betaine ABC transporter permease [Bacillus]

Protein Classification

ABC transporter permease( domain architecture ID 10790577)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates such as glycine betaine and trimethylamine N-oxide

Gene Ontology:  GO:0140359|GO:0042626|GO:0043190|GO:0016020
PubMed:  18535149|25750732|24638992|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ProW COG4176
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 3-273 1.68e-126

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 443335  Cd Length: 275  Bit Score: 360.57  E-value: 1.68e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504   3 SIPRIPLGEWVDSFVASLYEHFEGLFRGFSYIIGGFVDLLTNFLTIIPAILMIIILCFLIWYTtRKLSLVIFTLIGLLFI 82
Cdd:COG4176    5 EDPKIPLGDWVDAAVDWLTDNFGGFFDAISDVLEGLLDGLEDLLLALPWWVVILLVAALAWRL-RGWRLALFTALGLLLI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  83 LNINYWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVI 162
Cdd:COG4176   84 GNLGLWEEAMQTLALVLVAVLIALLIGIPLGILAARSDRVSRIVRPVLDFMQTMPAFVYLIPAVMLFGIGKVPGVIATVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 163 FAMPPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYR 242
Cdd:COG4176  164 FALPPAIRLTNLGIRQVPKELVEAADAFGATPWQLLFKVQLPLALPTIMAGVNQTIMLALSMVVIASMIGAGGLGQEVLR 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 447007504 243 SVTQVNIGMGFEAGLAIVVIAIILDRITQGF 273
Cdd:COG4176  244 ALQRLDIGLGFEAGLAIVILAIILDRITQAL 274
 
Name Accession Description Interval E-value
ProW COG4176
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 3-273 1.68e-126

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443335  Cd Length: 275  Bit Score: 360.57  E-value: 1.68e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504   3 SIPRIPLGEWVDSFVASLYEHFEGLFRGFSYIIGGFVDLLTNFLTIIPAILMIIILCFLIWYTtRKLSLVIFTLIGLLFI 82
Cdd:COG4176    5 EDPKIPLGDWVDAAVDWLTDNFGGFFDAISDVLEGLLDGLEDLLLALPWWVVILLVAALAWRL-RGWRLALFTALGLLLI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  83 LNINYWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVI 162
Cdd:COG4176   84 GNLGLWEEAMQTLALVLVAVLIALLIGIPLGILAARSDRVSRIVRPVLDFMQTMPAFVYLIPAVMLFGIGKVPGVIATVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 163 FAMPPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYR 242
Cdd:COG4176  164 FALPPAIRLTNLGIRQVPKELVEAADAFGATPWQLLFKVQLPLALPTIMAGVNQTIMLALSMVVIASMIGAGGLGQEVLR 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 447007504 243 SVTQVNIGMGFEAGLAIVVIAIILDRITQGF 273
Cdd:COG4176  244 ALQRLDIGLGFEAGLAIVILAIILDRITQAL 274
ABC_choXWV_perm TIGR03416
choline ABC transporter, permease protein;
6-270 6.93e-98

choline ABC transporter, permease protein;


Pssm-ID: 188318  Cd Length: 267  Bit Score: 288.09  E-value: 6.93e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504    6 RIPLGEWVDSFVASLYEHFEGLFRGFSYIIGGFVDLLTNFLTIIPAILMIIILCFLIWYTTRKLSLVIFTLIGLLFILNI 85
Cdd:TIGR03416   3 KIPIGAWAKSFVDWLTDNGAFFFDALAAVLESMIDGLLDLLQAPPPLLLIAIFAALAWWLQRSWSLALFVLLGLLLIINQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504   86 NYWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVIFAM 165
Cdd:TIGR03416  83 GYWKETTETLALVLSATVVCMVIGVPLGIAAAHRPWLYAAMRPVLDLMQTLPTFVYLIPALVLFGLGMVPGLIATVIFAI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  166 PPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYRSVT 245
Cdd:TIGR03416 163 PAPIRLTHLGISSVPQELVEAGEAFGATPSQLLWKVELPYALPQIMAGLTQTIMLSLSMVVIAALVGADGLGVPVVRALN 242

                         250       260
                  ....*....|....*....|....*
gi 447007504  246 QVNIGMGFEAGLAIVVIAIILDRIT 270
Cdd:TIGR03416 243 TVNIALGFEAGLAIVVLAIVLDRMF 267
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
7-273 7.54e-73

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 227.28  E-value: 7.54e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504   7 IPLGEWVDSFVASLYEHFEGLFRGF----SYIIGGFVDLLTNfltiiPAILMIIILCFLIWYTTRKLSLVIFTLIGLLFI 82
Cdd:PRK10952  63 IPLDSWVTEGIDWVVTHFRPVFQGIrvpvDYILNGFQQLLLG-----MPAPVAIIVFALIAWQISGVGMGVATLVSLIAI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  83 LNINYWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVI 162
Cdd:PRK10952 138 GAIGAWSQAMVTLALVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTII 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 163 FAMPPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYR 242
Cdd:PRK10952 218 FALPPIVRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLR 297

                        250       260       270
                 ....*....|....*....|....*....|.
gi 447007504 243 SVTQVNIGMGFEAGLAIVVIAIILDRITQGF 273
Cdd:PRK10952 298 GIGRLDMGLATVGGVGIVILAIILDRLTQAV 328
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 117-266 1.57e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 61.55  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  117 SQNERFSKFLKPTLDFMQTMPAFV-----YLIPAITFFGVGVVPGIIASVIFAMPPTIRFTDLGIRQVPEDLIEAANAFG 191
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFVlaillVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALG 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447007504  192 STASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGA-PGLGVDVYRSVTQVNIGMGFEAGLAIVVIAIIL 266
Cdd:pfam00528  91 ASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSwPGLGLLLIEAILGYDYPEIQGPVLAAALILLLL 166
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 115-266 2.84e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.14  E-value: 2.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 115 LASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVV---------PGIIASVIFAMPPTIRFTDLGIRQVPEDLIE 185
Cdd:cd06261   26 LARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGwgilpglglPALILALLLIAPFARLIRRAALESIPKDLVE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 186 AANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYRSVTQVNIGMGFEAGLAIVVIAII 265
Cdd:cd06261  106 AARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVAAAVALIL 185


                 .
gi 447007504 266 L 266
Cdd:cd06261  186 L 186
 
Name Accession Description Interval E-value
ProW COG4176
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 3-273 1.68e-126

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443335  Cd Length: 275  Bit Score: 360.57  E-value: 1.68e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504   3 SIPRIPLGEWVDSFVASLYEHFEGLFRGFSYIIGGFVDLLTNFLTIIPAILMIIILCFLIWYTtRKLSLVIFTLIGLLFI 82
Cdd:COG4176    5 EDPKIPLGDWVDAAVDWLTDNFGGFFDAISDVLEGLLDGLEDLLLALPWWVVILLVAALAWRL-RGWRLALFTALGLLLI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  83 LNINYWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVI 162
Cdd:COG4176   84 GNLGLWEEAMQTLALVLVAVLIALLIGIPLGILAARSDRVSRIVRPVLDFMQTMPAFVYLIPAVMLFGIGKVPGVIATVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 163 FAMPPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYR 242
Cdd:COG4176  164 FALPPAIRLTNLGIRQVPKELVEAADAFGATPWQLLFKVQLPLALPTIMAGVNQTIMLALSMVVIASMIGAGGLGQEVLR 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 447007504 243 SVTQVNIGMGFEAGLAIVVIAIILDRITQGF 273
Cdd:COG4176  244 ALQRLDIGLGFEAGLAIVILAIILDRITQAL 274
ABC_choXWV_perm TIGR03416
choline ABC transporter, permease protein;
6-270 6.93e-98

choline ABC transporter, permease protein;


Pssm-ID: 188318  Cd Length: 267  Bit Score: 288.09  E-value: 6.93e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504    6 RIPLGEWVDSFVASLYEHFEGLFRGFSYIIGGFVDLLTNFLTIIPAILMIIILCFLIWYTTRKLSLVIFTLIGLLFILNI 85
Cdd:TIGR03416   3 KIPIGAWAKSFVDWLTDNGAFFFDALAAVLESMIDGLLDLLQAPPPLLLIAIFAALAWWLQRSWSLALFVLLGLLLIINQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504   86 NYWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVIFAM 165
Cdd:TIGR03416  83 GYWKETTETLALVLSATVVCMVIGVPLGIAAAHRPWLYAAMRPVLDLMQTLPTFVYLIPALVLFGLGMVPGLIATVIFAI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  166 PPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYRSVT 245
Cdd:TIGR03416 163 PAPIRLTHLGISSVPQELVEAGEAFGATPSQLLWKVELPYALPQIMAGLTQTIMLSLSMVVIAALVGADGLGVPVVRALN 242

                         250       260
                  ....*....|....*....|....*
gi 447007504  246 QVNIGMGFEAGLAIVVIAIILDRIT 270
Cdd:TIGR03416 243 TVNIALGFEAGLAIVVLAIVLDRMF 267
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
7-273 7.54e-73

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 227.28  E-value: 7.54e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504   7 IPLGEWVDSFVASLYEHFEGLFRGF----SYIIGGFVDLLTNfltiiPAILMIIILCFLIWYTTRKLSLVIFTLIGLLFI 82
Cdd:PRK10952  63 IPLDSWVTEGIDWVVTHFRPVFQGIrvpvDYILNGFQQLLLG-----MPAPVAIIVFALIAWQISGVGMGVATLVSLIAI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  83 LNINYWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVI 162
Cdd:PRK10952 138 GAIGAWSQAMVTLALVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTII 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 163 FAMPPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYR 242
Cdd:PRK10952 218 FALPPIVRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLR 297

                        250       260       270
                 ....*....|....*....|....*....|.
gi 447007504 243 SVTQVNIGMGFEAGLAIVVIAIILDRITQGF 273
Cdd:PRK10952 298 GIGRLDMGLATVGGVGIVILAIILDRLTQAV 328
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 115-269 1.75e-28

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 108.22  E-value: 1.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 115 LASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVIFAMPPTIRFTDLGIRQVPEDLIEAANAFGSTA 194
Cdd:COG1174   44 LITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPAPAIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTP 123

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447007504 195 SQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYRSVTQVNIGMGFEAGLAIVVIAIILDRI 269
Cdd:COG1174  124 WQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAGGLGDLIFDGLQLNNTALILAGAILVALLALLVDLL 198
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 87-269 5.29e-18

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 80.96  E-value: 5.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  87 YWAQTMQTLALVLTSVIISIIVGIPIGILASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVVPGIIASVIFAMP 166
Cdd:COG0600   59 LWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFF 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 167 PTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAP-GLGVDVYRSVT 245
Cdd:COG0600  139 PILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALGLAWIGLVVAELLGASsGLGYLILDARQ 218

                        170       180
                 ....*....|....*....|....
gi 447007504 246 QVNIGMGFEAGLAIVVIAIILDRI 269
Cdd:COG0600  219 LLDTDLVFAAILVIGLLGLLLDLL 242
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 117-266 1.57e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 61.55  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504  117 SQNERFSKFLKPTLDFMQTMPAFV-----YLIPAITFFGVGVVPGIIASVIFAMPPTIRFTDLGIRQVPEDLIEAANAFG 191
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFVlaillVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALG 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447007504  192 STASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGA-PGLGVDVYRSVTQVNIGMGFEAGLAIVVIAIIL 266
Cdd:pfam00528  91 ASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSwPGLGLLLIEAILGYDYPEIQGPVLAAALILLLL 166
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 115-266 2.84e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.14  E-value: 2.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 115 LASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFGVGVV---------PGIIASVIFAMPPTIRFTDLGIRQVPEDLIE 185
Cdd:cd06261   26 LARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGwgilpglglPALILALLLIAPFARLIRRAALESIPKDLVE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 186 AANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPGLGVDVYRSVTQVNIGMGFEAGLAIVVIAII 265
Cdd:cd06261  106 AARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVAAAVALIL 185


                 .
gi 447007504 266 L 266
Cdd:cd06261  186 L 186
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 176-266 6.06e-05

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 43.60  E-value: 6.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 176 IRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPG---LGVDVYRSVTQV-NIGM 251
Cdd:COG1176  177 LEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGGKvlmIGNLIYQQFLSAlNWPL 256

                         90
                 ....*....|....*
gi 447007504 252 GfeAGLAIVVIAIIL 266
Cdd:COG1176  257 A--AALAVVLLLIVL 269
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 136-266 7.64e-05

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 43.18  E-value: 7.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 136 MPAFVYLIPAITFFG-VGVVPG----IIASVIFAMPPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTI 210
Cdd:COG1177  109 VPGIVLGVALLLLFSaLGLSGGlwglILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGI 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447007504 211 MAGVNQSIMLSLSMVVTASLVGAPG---LGVDVYRSVTQVNIGMGFEAGLAIVVIAIIL 266
Cdd:COG1177  189 LAGALLAFTLSFDEFVITLFLAGPGvttLPVYIYSMIRRGISPEINALSTLLILLSLLL 247
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 115-267 2.92e-04

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 42.14  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 115 LASQNERFSKFLKPTLDFMQTMPAFVYLIPAITFFgVGVVPGII----ASVIFAMpptirFTDL----------GIRQVP 180
Cdd:COG4986   87 LAAKSRRAEKILIPLLDILQSVPVLGFLSFTVTFF-IALFPGSLlgveLAAIFAI-----FTSQawnmafsfyqSLRTVP 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 181 EDLIEAANAFGSTASQKLFKVQLPLAtgtiMAGVNQSIMLSLS----MVVtAS---LVGA-----PGLGVDVYRSVTQVN 248
Cdd:COG4986  161 RDLDEAARIFRLSGWQRFWRLELPFA----MPGLVWNSMMSMSggwfFLV-ASeaiSVGNqdirlPGIGSYLALAIAQGD 235

                        170
                 ....*....|....*....
gi 447007504 249 IGMGFEAGLAIVVIAIILD 267
Cdd:COG4986  236 LGAIGWAILAMLVVILLYD 254
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
157-266 1.55e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 39.76  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447007504 157 IIASVIFAMPPTIRFTDLGIRQVPEDLIEAANAFGSTASQKLFKVQLPLATGTIMAGVNQSIMLSLSMVVTASLVGAPG- 235
Cdd:COG1178  415 VLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPGf 494

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447007504 236 --LGVDVYRSVTQVNIGMGFEAGLAIVVIAIIL 266
Cdd:COG1178  495 etLAVLIYQLASSGRYGEAAALALLLVLVSLLP 527
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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