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Conserved domains on  [gi|447012012|ref|WP_001089268|]
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MULTISPECIES: pro-sigmaK processing inhibitor BofA family protein [Bacillus]

Protein Classification

pro-sigmaK processing inhibitor BofA family protein( domain architecture ID 10021549)

pro-sigmaK processing inhibitor BofA family protein similar to Bacillus subtilis sigma-K factor-processing regulatory protein BofA that is involved in the mediation of the intercompartmental coupling of pro-sigma K processing to events in the forespore

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
spore_BofA TIGR02862
pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in ...
 4-86 7.03e-15

pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination]


:

Pssm-ID: 163046  Cd Length: 83  Bit Score: 63.07  E-value: 7.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012012   4 TIIIVGILSLVFIFLVFGVSSKPLRFIGKILFHVTLGIALLFIVNVVGTYFDFHIPINAGTATVTSLLGLPGVAALVIIK 83
Cdd:TIGR02862  1 ELIISIILGLVILLLIVGAPVKPLRLIGKAAINLIIGALLLFIVNVFGGAFGIHIPINLVTATIAGFLGLPGIALLVAIK 80


                 ...
gi 447012012  84 LYI 86
Cdd:TIGR02862 81 LFI 83
 
Name Accession Description Interval E-value
spore_BofA TIGR02862
pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in ...
 4-86 7.03e-15

pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination]


Pssm-ID: 163046  Cd Length: 83  Bit Score: 63.07  E-value: 7.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012012   4 TIIIVGILSLVFIFLVFGVSSKPLRFIGKILFHVTLGIALLFIVNVVGTYFDFHIPINAGTATVTSLLGLPGVAALVIIK 83
Cdd:TIGR02862  1 ELIISIILGLVILLLIVGAPVKPLRLIGKAAINLIIGALLLFIVNVFGGAFGIHIPINLVTATIAGFLGLPGIALLVAIK 80


                 ...
gi 447012012  84 LYI 86
Cdd:TIGR02862 81 LFI 83
BofA COG5848
SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, ...
 4-87 2.00e-13

SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444550  Cd Length: 88  Bit Score: 59.42  E-value: 2.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012012  4 TIIIVGILSLVFIFLVFGVSSKPLRFIGKILFHVTLGIALLFIVNVVGTYFDFHIPINAGTATVTSLLGLPGVAALVIIK 83
Cdd:COG5848   5 NVILAILVGLLLLLLVGGALLKPLKWLGKLILNLLIGALLLFLVNLFGGFFGFHIPINPVTALIAGFLGLPGVALLVVLK 84


                ....
gi 447012012 84 LYIM 87
Cdd:COG5848  85 LFLL 88
BofA pfam07441
SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor ...
 11-83 9.71e-10

SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein.


Pssm-ID: 462165  Cd Length: 73  Bit Score: 49.75  E-value: 9.71e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447012012  11 LSLVFIFLVFGVSSKPLRFIGKILFHVTLGIALLFIVNVVGTYFDFHIPINAGTATVTSLLGLPGVAALVIIK 83
Cdd:pfam07441  1 IGILLLLLVIKVLKKPLKLLLKLVINAVLGLVLLFLVNLLGAFFGFHIPINPVTALIAGILGIPGVILLLLLK 73
 
Name Accession Description Interval E-value
spore_BofA TIGR02862
pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in ...
 4-86 7.03e-15

pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination]


Pssm-ID: 163046  Cd Length: 83  Bit Score: 63.07  E-value: 7.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012012   4 TIIIVGILSLVFIFLVFGVSSKPLRFIGKILFHVTLGIALLFIVNVVGTYFDFHIPINAGTATVTSLLGLPGVAALVIIK 83
Cdd:TIGR02862  1 ELIISIILGLVILLLIVGAPVKPLRLIGKAAINLIIGALLLFIVNVFGGAFGIHIPINLVTATIAGFLGLPGIALLVAIK 80


                 ...
gi 447012012  84 LYI 86
Cdd:TIGR02862 81 LFI 83
BofA COG5848
SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, ...
 4-87 2.00e-13

SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444550  Cd Length: 88  Bit Score: 59.42  E-value: 2.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012012  4 TIIIVGILSLVFIFLVFGVSSKPLRFIGKILFHVTLGIALLFIVNVVGTYFDFHIPINAGTATVTSLLGLPGVAALVIIK 83
Cdd:COG5848   5 NVILAILVGLLLLLLVGGALLKPLKWLGKLILNLLIGALLLFLVNLFGGFFGFHIPINPVTALIAGFLGLPGVALLVVLK 84


                ....
gi 447012012 84 LYIM 87
Cdd:COG5848  85 LFLL 88
BofA pfam07441
SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor ...
 11-83 9.71e-10

SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein.


Pssm-ID: 462165  Cd Length: 73  Bit Score: 49.75  E-value: 9.71e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447012012  11 LSLVFIFLVFGVSSKPLRFIGKILFHVTLGIALLFIVNVVGTYFDFHIPINAGTATVTSLLGLPGVAALVIIK 83
Cdd:pfam07441  1 IGILLLLLVIKVLKKPLKLLLKLVINAVLGLVLLFLVNLLGAFFGFHIPINPVTALIAGILGIPGVILLLLLK 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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