|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-392 |
7.72e-88 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 270.57 E-value: 7.72e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 21 LLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGI 100
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 101 AAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIV 180
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 181 VIGIIALIANSILIPSN--MKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIIL 258
Cdd:cd17324 161 VLALLAALLLWRLLPSLppKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 259 LVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAerfv 338
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA---- 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447012635 339 PSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTA 392
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
13-395 |
1.82e-71 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 229.39 E-value: 1.82e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 13 TNRRSIFALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMI 92
Cdd:PRK03545 3 SRKVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 93 IFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGW 172
Cdd:PRK03545 83 LFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 173 RTSFLAIVVIGIIALIANSILIPSNMKKGASvSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKAN 252
Cdd:PRK03545 163 RTTFLAIGGGALITLLLLIKLLPLLPSEHSG-SLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSEN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 253 TVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVM 332
Cdd:PRK03545 242 FATLLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLK 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447012635 333 LAerfvPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAWSM 395
Cdd:PRK03545 322 LA----PDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSILIF 380
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
21-388 |
1.03e-60 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 201.09 E-value: 1.03e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 21 LLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGI 100
Cdd:PRK10091 5 ILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 101 AAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIV 180
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 181 VIGIIALIANSILIPsNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLV 260
Cdd:PRK10091 165 VFNIAVLASIYFWVP-DIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMML 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 261 YGIAIAIGNVIGGKLSN-HNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIIL--MGLFAfmnvpgLQVYVVMLAERF 337
Cdd:PRK10091 244 VGLGMVLGNLLSGRLSGrYSPLRIAAVTDFIIVLALLMLFFFGGMKTASLIFAFIccAGLFA------LSAPLQILLLQN 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447012635 338 VPSAVDVASAINIAAFNAGIALGAYLGGI-VTNSLGLIHTAWVGGIMVVGAV 388
Cdd:PRK10091 318 AKGGELLGAAGGQIAFNLGSAIGAYCGGMmLTLGLAYNYVALPAALLSFAAM 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-359 |
3.84e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 151.28 E-value: 3.84e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 12 QTNRRSIFALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIM 91
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 92 IIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFG 171
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 172 WRTSFLAIVVIGIIALIANSILIPSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKA 251
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 252 NTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVv 331
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV- 321
|
330 340
....*....|....*....|....*...
gi 447012635 332 mlAERFVPSAVDVASAINIAAFNAGIAL 359
Cdd:COG2814 322 --AELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-393 |
8.15e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 109.97 E-value: 8.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 24 LAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAV 103
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 104 ATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIG 183
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 184 IIALIANSILIPSNMKKGASVSFRDQ------FKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTII 257
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAArlrsglRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 258 LLVYGIAIAIGNVIGGKLSN-HNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLqvyvVMLAER 336
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDrIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL----ALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447012635 337 FVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
20-392 |
1.29e-26 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 110.01 E-value: 1.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 20 ALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNG 99
Cdd:PRK10213 21 AVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 100 IAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAI 179
Cdd:PRK10213 101 LVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 180 VVIGIIALIANSILIPSnMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILL 259
Cdd:PRK10213 181 AVMGVLCIFWIIKSLPS-LPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 260 VYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGlFAFMNVP-GLQVYVVmlaeRFV 338
Cdd:PRK10213 260 SFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWG-LTFALVPvGWSTWIT----RSL 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447012635 339 PSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTA 392
Cdd:PRK10213 335 ADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVT 388
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
41-392 |
3.15e-26 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 108.43 E-value: 3.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALS 120
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGqQFGWRTSFLAIVVIGIIALIANSILIPSNMKK 200
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 201 GASVS---FRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSN 277
Cdd:cd17474 180 AKSSSatkLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 278 H--NPIRALFYMFFIQAIILFVLTFtAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVdvaSAINIAAFNA 355
Cdd:cd17474 260 KrfGARRILVIGLLLYALSLLLLGF-VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTA---SSLYNFVRFL 335
|
330 340 350
....*....|....*....|....*....|....*..
gi 447012635 356 GIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTA 392
Cdd:cd17474 336 GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-400 |
2.44e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.12 E-value: 2.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 22 LALAISAFGIGTTEFVSVGLL-PSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGI 100
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 101 AAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIV 180
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 181 VIGIIALIANSILI---PSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTII 257
Cdd:COG2223 167 ILLLVVAVLAWLFLrdpPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 258 LLVYGIAIAIGNVIGGKLSN-HNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMnvpGLQVYVVMLAER 336
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDrIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG---GNGAVFALVPDI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447012635 337 FVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTA-WVGGIMVVGAVILTAWSMTLEKR 400
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALVALVLTLLLYRRPRR 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-393 |
3.44e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.34 E-value: 3.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 13 TNRRSIFALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMI 92
Cdd:COG2271 4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 93 IFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGW 172
Cdd:COG2271 84 LWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 173 RTSFLAIVVIGIIALIAnsilipsnmkkgasvsfrdqfklitngRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKAN 252
Cdd:COG2271 164 RAAFLILGLPGLLLALL---------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 253 TVTIILLVYGIAIAIGNVIGGKLSNHnPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVM 332
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDR-LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447012635 333 LAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
42-395 |
2.31e-24 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 103.06 E-value: 2.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:cd17489 19 LPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSIL-IPSNMKK 200
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVkDPPPVAA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 201 GASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLsPLLQEVTGFKAntVTIILLVYGIAIAIGNVIGGKLSN-HN 279
Cdd:cd17489 179 EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFL-PLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDrKG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 280 PIRALFYMFFIQAIILFVLTFTAPFKVAgLITIILMGLFAFMNVPGLQVYVVMLAErfvPSAVDVASAINIAAFNAGIAL 359
Cdd:cd17489 256 PKTVIIPGLLLLALGLLLLSFAGSPWML-LLAAVLYGLGFGLLFPALQALAVDLVP---PHRRGAANGTFFIFFDLGIGL 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 447012635 360 GAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAWSM 395
Cdd:cd17489 332 GGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-361 |
3.87e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.41 E-value: 3.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 24 LAISAFGIGTTEFVSVGLLPS-ISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAA 102
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 103 VATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVI 182
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 183 GIIALIANSILIPSNMKKGASVSFRDQFKLITNGRLL-----LVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTII 257
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALlrdpvLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 258 LLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERF 337
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 447012635 338 VPSAVDVASAINIAAFNAGIALGA 361
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
42-388 |
8.31e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 98.78 E-value: 8.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIAnsilipsnmkkg 201
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 202 asvsfrdqfklitnGRLLLVFIITALGYGGTFVTFTYLSPL-LQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNP 280
Cdd:cd17321 167 --------------ARTFSGAVLAAFLLGAALGGLLFLLPLyLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 281 IRAL-FYMFFIQAIILFVLTFTAP--FKVAGLITIILMGLFAFMNVPGLQVYVVMLAErfvPSAVDVASAINIAAFNAGI 357
Cdd:cd17321 233 PRLVlVAGLLLTAVGLLLLALLGAdsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVP---KEKAGAASGILNTARQLGG 309
|
330 340 350
....*....|....*....|....*....|.
gi 447012635 358 ALGAYLGGIVTNSLGLIHTAWVGGIMVVGAV 388
Cdd:cd17321 310 ALGVALLGALLTAGLSANLGDSGVAALLSAA 340
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
42-361 |
2.03e-22 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 97.65 E-value: 2.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILipsnmkkg 201
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL-------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 202 asvsfrdQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPI 281
Cdd:cd17503 171 -------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 282 RAL----FYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVDVASAINIAAFNAGI 357
Cdd:cd17503 244 RLLllagLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGT 323
|
....
gi 447012635 358 ALGA 361
Cdd:cd17503 324 ALLA 327
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
42-369 |
9.00e-22 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 95.72 E-value: 9.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPS----- 196
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPEtlpee 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 197 NMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLS 276
Cdd:cd17320 182 KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 277 NHNPIRALFYM-FFIQAIILFVLTFTAPFKVAGLITIILmGLFAFMNVPGLQVYVVM-LAERFVPSAVDVASAINIAAFN 354
Cdd:cd17320 262 RRFGPRRLLRLgLLLLLAAALVLLLAALLGGLSLWPLVA-PLFLIFFGFGLIFPNATsLALEPFPHVAGTASALLGFLQF 340
|
330
....*....|....*
gi 447012635 355 AGIALGAYLGGIVTN 369
Cdd:cd17320 341 LIGALAGALVGLLPN 355
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-394 |
1.05e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 86.86 E-value: 1.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 51 VSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGST 130
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 131 IAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGqQFGWRTSFLaIVVIGIIALIANSILIPSNMKKGASVSFRDQF 210
Cdd:cd17473 112 LIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFL-VYLLALPVLILVLLFLPEPARKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 211 KL--ITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMF 288
Cdd:cd17473 190 TAaaLPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 289 FIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLqvyVVMLAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVT 368
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTL---NSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV 346
|
330 340
....*....|....*....|....*...
gi 447012635 369 NSLGLIHTAW--VGGIMVVGAVILTAWS 394
Cdd:cd17473 347 NLTGGLSGAFliLGVLALVLAIVLLLLR 374
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
42-363 |
2.43e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 85.70 E-value: 2.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:cd17323 22 LPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSnmkkg 201
Cdd:cd17323 102 SSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 202 asvsfrdqfklitngrLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNH--- 278
Cdd:cd17323 177 ----------------VLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYyyr 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 279 ---------NPIRALFYMFFIQAII----LFVLTFTAPFKV---AGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAV 342
Cdd:cd17323 241 rlkkknggkPEPEARLPPAFIGAFLfpigLFIFGWTIYPHIhwiVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASAL 320
|
330 340
....*....|....*....|.
gi 447012635 343 DVASAINIAAFNAGIALGAYL 363
Cdd:cd17323 321 AANTLVRSIFAAIFPLFAQPM 341
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
42-363 |
8.71e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 84.33 E-value: 8.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:TIGR00895 40 APAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIAL-------------- 187
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLlllmrflpesidfl 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 188 ----------IANSILIPSNMKKGASVS--------FRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLS---PLLQEV 246
Cdd:TIGR00895 200 vskrpetvrrIVNAIAPQMQAEAQSALPeqkstqgtKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTnwlPKLMVE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 247 TGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTApFKVAGLitiILMGLFAFMNVPGL 326
Cdd:TIGR00895 280 LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTL-FSPTLL---LLLGAIAGFFVNGG 355
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 447012635 327 QVYVVMLAERFVPSAV---DVASAINIAAFNAGI--ALGAYL 363
Cdd:TIGR00895 356 QSGLYALMALFYPTAIratGVGWAIGIGRLGAIIgpILAGYL 397
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-390 |
1.76e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 83.00 E-value: 1.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALS 120
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSnmkk 200
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 201 gasvsfrdqfklitngrlLLVFIITALGYGGTFVTF-TYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHN 279
Cdd:cd17319 181 ------------------VWGLALGYFGINYALYGLlTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 280 PIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVDVASAINIAAFNAGIAL 359
Cdd:cd17319 243 LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFV 322
|
330 340 350
....*....|....*....|....*....|...
gi 447012635 360 GAYLGGIVTNSLGLIHTAW--VGGIMVVGAVIL 390
Cdd:cd17319 323 APLLIGYLVDATGSYTAAFlfLAAVALLAALLV 355
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-393 |
6.59e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.70 E-value: 6.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 24 LAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAV 103
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 104 ATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQ--FGWRTSFLAIVV 181
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 182 IGIIALIANSILIPS--------NMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANT 253
Cdd:cd06174 161 LALLAAILLLLVVPDppesarakNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 254 VTIILLVYGIAIAIGNVIGGKLSNHN-PIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMnvpGLQVYVVM 332
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG---LLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447012635 333 LAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-393 |
2.83e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.90 E-value: 2.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 12 QTNRRSIFALLALAISAFGIGTTefVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIM 91
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATA--LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 92 IIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENkRASAIAIMFTGVTVATITGAPIGTFI---GQ 168
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLillGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 169 QFGWRTSFL--AIVVIGIIALIANSILIPSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTF-TYLSPLLQE 245
Cdd:COG0738 160 SLSWHLPYLilAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIgDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 246 VTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPG 325
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447012635 326 LQVYVvmlAERFVPSAVDVASAINIAAFnAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:COG0738 320 IFSLA---LDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
41-392 |
3.60e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 79.14 E-value: 3.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALS 120
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVFMSIGSTIAAALVPENkRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSNMKK 200
Cdd:cd17478 98 SAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 201 GASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLS--PLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNH 278
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTflPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 279 NPIRALFYMFFIQAIILFVLTFTAPFkVAGLITIILMGLFAFMNVPglqvYVVMLAERFVPSAVDVASAINIAAFNAGIA 358
Cdd:cd17478 257 FGRRRVIIASLLLAAPFLLLFLLTPG-IWSYILLVLAGFLLFASFP----VTVVLAQELLPGNVGLASGLMMGLSFGLGG 331
|
330 340 350
....*....|....*....|....*....|....
gi 447012635 359 LGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTA 392
Cdd:cd17478 332 IGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-300 |
8.00e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 77.54 E-value: 8.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 7 SSSEVQTNRRSIFALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTL 86
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 87 LMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFI 166
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 167 GQQFGWRTSFLAIVVIGIIALIANSILIPSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEV 246
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 447012635 247 TGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTF 300
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
19-390 |
1.72e-15 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 77.28 E-value: 1.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 19 FALLALAISAFGIGTtefvsvgLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGN 98
Cdd:cd17475 3 LAQAAASLVAQGIPA-------LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 99 GIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLA 178
Cdd:cd17475 76 LLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 179 IVVIGIIALIANSILI-----PSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANT 253
Cdd:cd17475 156 AGLVSILAAVLFWLFYreppaASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 254 VTIILLVYGIAIAIGNVIGGKLSNH----NPIRALFYMFFIQAIILFVLTFTAPFKVAGLITI--ILMGLFAFMNVPglq 327
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRvfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLllILLGLFAIGWNG--- 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447012635 328 VYVVMLAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAW--VGGIMVVGAVIL 390
Cdd:cd17475 313 LYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWlaLALLLVLAALLL 377
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-392 |
2.30e-15 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 76.87 E-value: 2.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 18 IFALLALAISAFGIGTTEFVSVGLLPSISedLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIG 97
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFS--LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 98 NGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFI----GQQFGWR 173
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 174 TSFLAIVVIGIIALIANSilipsnmkkgasvsfrdqfklitngRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANT 253
Cdd:cd17316 160 ILFLIGALPALLALLLRR-------------------------RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPAT 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 254 VTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMgLFAFMNVPGLQVYVVML 333
Cdd:cd17316 215 SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLF-ILSFFVGGVWGALYAYL 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 334 AERFVPSAVDVASAINIAAFNAGIALGAYLGG-IVTNSLGLIHTAWVGGIMVVGAVILTA 392
Cdd:cd17316 294 AELFPTEVRATGVGLSYNLGRLGGGGAPPLIAlLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
41-349 |
3.86e-15 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 75.68 E-value: 3.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHvSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALS 120
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALiansILIPSnmkk 200
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLAL----ALLRT---- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 201 gasvsfrdqfklitngrLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKL-SNHN 279
Cdd:cd17502 169 -----------------ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALiSKTG 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 280 PIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVDVASAIN 349
Cdd:cd17502 232 RYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATN 301
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-367 |
1.02e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 74.92 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 24 LAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAV 103
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 104 ATSFTVLLIARIISALSHGVFmSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIG 183
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 184 IIALIANSILIPsnmkkgasvsfrdqfKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVT----GFKANTVTIILL 259
Cdd:cd17504 160 VLLAALVPLIDL---------------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 260 VYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLIT-IILMGLFAFMNVPGLQVYVVMLAERFV 338
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVaLLLIGIGLGLAFASLPNIVVESVPPDR 304
|
330 340
....*....|....*....|....*....
gi 447012635 339 PSAvdvASAINIAAFNAGIALGAYLGGIV 367
Cdd:cd17504 305 TGI---ATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
41-342 |
2.91e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.39 E-value: 2.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALS 120
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIansilipsnmkk 200
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP------------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 201 gasvsfrdqFKLITngrlLLVFIITALGYGGTFVTFTYLsPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNH-N 279
Cdd:cd17365 169 ---------LLRGT----LLLWVTFFMGLLLVYLLNSWL-PKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRfG 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447012635 280 PIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFafmnVPGLQVYVVMLAERFVPSAV 342
Cdd:cd17365 235 PKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGAC----VNGAQVGLYALAARFYPTEV 293
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-395 |
5.04e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.98 E-value: 5.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 5 TASSSEVQTNRRSIFALLALAISAFGIGTTeFVSVG-LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSR 83
Cdd:COG2807 4 TSSSARRSRRAGRWLLLLAIVLVALNLRPA-ITSVGpLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 84 KTLLMWIMIIFIIGNGIAAVATSFTVLLIARiisalshgVFMSIGSTIAAALVP-------ENKRASAIAIMFTGVTVAT 156
Cdd:COG2807 83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGT--------ALIGAGIAVGNVLLPglikrwfPDRVGLMTGLYTAAMGLGA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 157 ITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSNMKKGASVSFRDQFK-LITNGRLLLVFIITALGYGGTFVT 235
Cdd:COG2807 155 ALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRsLWRSPLAWLLTLFFGLQSLLYYAV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 236 FTYLSPLLQEvTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILM 315
Cdd:COG2807 235 VAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 316 GLFAFMNVPglqVYVVMLAERFvPSAVDVA--SAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:COG2807 314 GLGQGGLFP---LALTLIGLRA-RTPAEAAalSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
..
gi 447012635 394 SM 395
Cdd:COG2807 390 LA 391
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
41-392 |
8.02e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 69.25 E-value: 8.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALS 120
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVFMSIGSTIAAALVPENKRASAIAIMFTGVTV----ATITGAPIGTFIGQQFGWRTSFL-----AIVVIGIIALIANS 191
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFLlgalpALLVLFIRRFVKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 192 ILIPSNMKKGASVSFRDQFKLITNGRLLLVFIITAL----GYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAI 267
Cdd:cd17371 181 PQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 268 GNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFtaPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVDVASA 347
Cdd:cd17371 261 GYLAGGFLADRIGRRNNFALFALGSAISILLYF--FLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447012635 348 INIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTA 392
Cdd:cd17371 339 FCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
45-393 |
4.87e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 66.87 E-value: 4.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 45 ISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVF 124
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 125 MSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGqQFGWRTSFLAIVVIGIIALIANSILIPSNMKKGASV 204
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 205 SFRDQFK----LITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNP 280
Cdd:cd17329 185 EKTEILRgykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 281 IRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAErfvPSAVDVASAINIAAFNAGIALG 360
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAP---PDKRGSYMGFYALAWGLGRAIG 341
|
330 340 350
....*....|....*....|....*....|...
gi 447012635 361 AYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:cd17329 342 PLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-394 |
1.51e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 65.33 E-value: 1.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 52 SVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVAT-----SFTVLLIARIISALSHGVFMS 126
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 127 IGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSNMKKGASVSF 206
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 207 RDQ-------FKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHn 279
Cdd:cd06173 192 LLLrdlreglRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 280 piRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVDVASAINIAAFNAGIAL 359
Cdd:cd06173 271 --RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348
|
330 340 350
....*....|....*....|....*....|....*
gi 447012635 360 GAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAWS 394
Cdd:cd06173 349 GALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-393 |
4.87e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 63.75 E-value: 4.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 20 ALLALAISAFGIGTTeFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNG 99
Cdd:cd17330 1 LFLVVFLDALGFGIV-FPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 100 IAAVATSFTVLLIARIISALSHGVFmSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAI 179
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 180 VVIGIIALIANSILIPSNMkkgasvsfrdqfklitngRLLLVFIITALGYGGTFVTFTYLSPllqEVTGFKANTVTIILL 259
Cdd:cd17330 159 AALALLNLVLVLFFLPPLR------------------RLLLVYFLIALAFAGLESVFSLFLK---DRFGFSPSQIGLLLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 260 VYGIAIAI--GNVIGGKLSNHNPIRALFYMFFIqAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQvyvVMLAERF 337
Cdd:cd17330 218 LVGIAGILaqLLLIPRLAKRLGERKLLRLGLLL-AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS---ALLSKSV 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447012635 338 VPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:cd17330 294 PSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
45-319 |
1.12e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 63.02 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 45 ISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVF 124
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 125 MSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFL-----AIVVIGIIALIANSILIPSNMK 199
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFvgllpVLLVIYIRARAPESKEWEEAKL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 200 KG-----------ASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEvTGFKANTVTIILLVYGIAIAIG 268
Cdd:PRK12307 204 SGkgkhsqsawsvFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAG-EGFDTGVVSNLMTAAAFGTVLG 282
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 447012635 269 NVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFA 319
Cdd:PRK12307 283 NIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMA 333
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
24-393 |
1.32e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 62.29 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 24 LAISAFGIGTTEFVsvgLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAV 103
Cdd:cd17355 11 ILILSWGIRYYFGV---FIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 104 ATSFT--VLLIARIISALSHGVFMSIGSTIAAaLVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVV 181
Cdd:cd17355 88 ATSLWqlYLLWGLLGGGGAGTLAAVAFATVAA-WWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 182 IGIIALIANSILIPSNMKKGASVSFRDQF---------KLITNGRLLLVFIITAL-GYGGTFVTFTYLSPLLQEvtGFKA 251
Cdd:cd17355 167 LALLVLVPVLLLLRRRPADLALRAYDDASpaspgstlkEALRSASFWLLALAFFLcGFAVVGLIVHLVPYLADR--GISP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 252 NTVTIILLVYGIAIAIGNVIGGKLSN-HNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPglqVYV 330
Cdd:cd17355 245 AAAAVALALIGLFNIVGRLLSGWLGDrYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVP---LTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447012635 331 VMLAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTAW 393
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
35-383 |
1.52e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 59.17 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 35 EFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIAR 114
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 115 IISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQF-GWRTSFLAIVVIGIIALIANSIL 193
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 194 IPSNMKKGASVSFRDQFKLITNGRLL------LVFIITALGY-GGTFVT--FTYLSP-LLQEVTGFKANTVTIILLVYGI 263
Cdd:cd17328 175 VREPPRGAAEGGVMAKSTATSFLADLkalaknPSFILSTLGFtAVSFVTgaLAFWAPtFFLRAFGVGDLSSADVGLIFGA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 264 AIAIGNVIGG-------KLSNHNPIRALFYM----FFIQAIILFVLTFTAPFKVAGLITIILMG-LFAFMN---VPGLQV 328
Cdd:cd17328 255 ITCIAGVLGVllggilaDRLRRKTPRADPLVcavgLLAAAPFLFLALVLALSNLLLAWVLLFLGeFLLSLNwapVFAILL 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447012635 329 YVVmlaerfVPSAVDVASAINIAAFNA-GIALGAYLGGIVTNSLGLIHTAWVGGIM 383
Cdd:cd17328 335 YVV------IPTRRSTASAIQILLSHLlGDAGSPYLIGLISDLLRQNKDSPLAEAA 384
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
36-391 |
2.02e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 58.77 E-value: 2.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 36 FVSVGLLPSISEDLHVSVTTAGLTVSLYALG-VAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIAR 114
Cdd:cd17490 13 YVYVPFLSPYAESLGASLSMIGIILGAYGISqMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIAR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 115 IISALSHGVFMSIgSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIAnSILI 194
Cdd:cd17490 93 FLSGIAAATWVSF-TVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFIL-SLFI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 195 --PSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIG 272
Cdd:cd17490 171 keERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 273 G-----KLSNHNPI--------RALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLfAFMNVPGLQVYVVMlaerfvp 339
Cdd:cd17490 251 GtlfykKLGERNTIiigflllgAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSL-SIEGVPAEQRSTAM------- 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447012635 340 savdvasAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILT 391
Cdd:cd17490 323 -------GFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
40-389 |
2.31e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 58.73 E-value: 2.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 40 GLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISAL 119
Cdd:cd17359 22 GALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 120 SHGVFMSIGSTIAAALVPENKRASA-----IAIMFtGVTVATITGAPIGTFIGQQF----GWRTSFLAIVVIGIIALIAn 190
Cdd:cd17359 102 AVGGASALVPMYIAEVAPAEIRGRLvslnqLMIVF-GQLLAYIVNYLIANAGGADWlgaeGWRWMLGLEAIPAILFLLG- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 191 SILIPSnmkkgasvSFRdqfKLITNGRLLLV--FIITALG-YGGTFVTFTYLSPLLQEVtGFKANTVTIILLVYGIAIAI 267
Cdd:cd17359 180 MLFIPE--------SPR---WLVSKGKPILIigIGLAIFQqFVGINVIFYYGPEIFQNA-GFSENAALLQTIGIGVVNVI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 268 GNVIGGKLSNHNPIRALFY-----MFFIQAIILFVLTFTAPFKVAGLITIILMGLF-AFMNVPGLQVYVVMLAERFVPSA 341
Cdd:cd17359 248 FTIIAILLVDKVGRKPLLLigsigMAISLLLIGTAFYFAPGSQASGIVALVLILLFvAFFAMSWGPVTWVLLSEIFPNRI 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 447012635 342 VDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVI 389
Cdd:cd17359 328 RGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFL 375
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
42-206 |
2.60e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.93 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:TIGR00711 25 IPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPsNMKKG 201
Cdd:TIGR00711 105 GPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILP-RDKPA 183
|
....*
gi 447012635 202 ASVSF 206
Cdd:TIGR00711 184 ASENF 188
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
56-394 |
6.14e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 57.27 E-value: 6.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 56 AGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGvFMSIGSTIAAAL 135
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 136 VPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSNMK---KGASVSFRDQFKL 212
Cdd:cd17391 117 TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKpveKKKMVSTKEVWNS 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 213 ITNGRLLLV-FIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTI---ILLVYGIAIAIGNVIGGKLSN-HNPIRALFYM 287
Cdd:cd17391 197 VPNPSLLISlFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFIsglVFSATGVSSLLSAPRLGKLGDrIGHHRILLGA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 288 FFIQAIILFVLTF-TAPFKVAGLitIILMGLFAFMNVPGLQVYVVMLAERFVPSAVdvaSAINIAAFNAGIALGAYLGGI 366
Cdd:cd17391 277 LLASALLYIPQAFvQTPWQLGIL--RFLLGLATGGLLPAINSLLAKITPKEVAGRI---FGYNQSFQYLGNVAGPLLGSA 351
|
330 340
....*....|....*....|....*...
gi 447012635 367 VTNSLGLIHTAWVGGIMVVGAVILTAWS 394
Cdd:cd17391 352 IAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
14-189 |
8.17e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.78 E-value: 8.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 14 NRRSIFALLALAISAFGigtteFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMII 93
Cdd:cd17370 199 PKAFWLYLLAVALFALG-----NFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 94 FIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWR 173
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPS 353
|
170
....*....|....*.
gi 447012635 174 TSFLAIVVIGIIALIA 189
Cdd:cd17370 354 AAFLFSAVLALIALLL 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-195 |
9.72e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.42 E-value: 9.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 18 IFALLALAISAFGIGTTEFVSVGLLPSI-SEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSR--KTLLMWIMIIF 94
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 95 IIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRT 174
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 447012635 175 SFLAIVVIGIIALIANSILIP 195
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
18-392 |
3.00e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 55.00 E-value: 3.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 18 IFALLALAIsafGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIG 97
Cdd:cd06180 1 LAGALALAV---AMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 98 NGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVAT-ITGAPIGTFIGQQFGWRTSF 176
Cdd:cd06180 78 LAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIaLSGLLVPAGLGGGLSWRAGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 177 LAIVVIGIIALIANSILIPSNMKK--GASVSFRDQFKLITNGRLLLVFIITALGYggtFVTFTYLsPLLQEVTGFKANTV 254
Cdd:cd06180 158 LALALLSAVLLLLSFLLLRRGPSAptEASAAESAPGLNRPLWRLALAYGLFGFGY---IITATFL-PLIARETGAGSLLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 255 TIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGlFAFMNVPGLqvyVVMLA 334
Cdd:cd06180 234 GLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFG-GTFMAITAL---VMALA 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 335 ERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTA--WVGGIMVVGAVILTA 392
Cdd:cd06180 310 RELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPAliLAAAALVVAALLALL 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-367 |
3.42e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 12 QTNRRSIFALLALAISAFGIG-TTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANM-----SRKT 85
Cdd:COG2211 3 AKKKLSLKEKLAYGLGDLGLNlAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwgRRRP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 86 LLMWIMIIFIIGNGIAAVATSFT------VLLIARIISALSHGVFMSIGSTIAAALVPENK-RASAIAIMFTGVTVATIT 158
Cdd:COG2211 83 WILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 159 GAPIGTFI------GQQFGWRTSFLAIVVIGIIALIANSILIPSNMK-KGASVSFRDQFKLI-TNGRLLLVFIITALGYG 230
Cdd:COG2211 163 ASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVpEEEKVSLKESLKALlKNRPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 231 GTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNH-NPIRALFYMFFIQAIILFVLTFTAPFKVAGL 309
Cdd:COG2211 243 ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRfGKKKAFIIGLLLAALGLLLLFFLGPGNLWLL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447012635 310 ItiILMGLFAFMNVPGLQVYVVMLAE-------RFVPSAVDVASAINIAAFNAGIALGAYLGGIV 367
Cdd:COG2211 323 L--VLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
41-391 |
4.73e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.54 E-value: 4.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLiariisaLS 120
Cdd:cd17353 25 FNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF-------LG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVFMSIGSTIA-AALVP------ENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSIL 193
Cdd:cd17353 98 YGVLGGIGAGIGyITPVStavkwfPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 194 I-------------PSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLV 260
Cdd:cd17353 178 IrdppkgwvppgvdPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 261 YGIAIAIGNVIGGKLSNH-NPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGlfaFMNVPGLQVYVVMLAERFVP 339
Cdd:cd17353 258 LSIFNGGGRPFWGWLSDKiGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIG---FCYGGGFALFPALTADFFGT 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447012635 340 SAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILT 391
Cdd:cd17353 335 KNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALA 386
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
18-300 |
4.81e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 54.56 E-value: 4.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 18 IFALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIG 97
Cdd:cd17388 2 IFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 98 NGIAAVATSFTVLLIARIISALSHGVFMSIGSTIaAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGqQFGWRTSFL 177
Cdd:cd17388 82 YLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYI-ADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 178 AIVVIGIIALIANSILIPSNMKKGASVSFRDQ-------FKLITN----GRLLLVFIITALGYGGTFVTFTYLSpllQEV 246
Cdd:cd17388 160 VAAGLNGLNFLLGLFVLPESLPPERRRAFRWRranpfgsLRWLTGfpglLGLLAVFFLIQLIGQVPATTWVLFT---EDR 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 447012635 247 TGFKANTVTIILLVYGIAIAI--GNVIGGKLSNHNPIRALFYMFFIQAIILFVLTF 300
Cdd:cd17388 237 FDWSPTMVGLSLAVFGLLHALfqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAF 292
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-390 |
5.27e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.25 E-value: 5.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 24 LAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAV 103
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 104 ATSFTVLLIARIISALSHGVFMSIGSTIAAALVPEnKRASAIAIMFTGVTVATITGAPIGTFIGQQ-FGWRTSFLAIVVI 182
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 183 GIIALIANSI-LIPSNMKKGASVSFRDQFKLITNGRLLLVFIITA-----LGYGGTFVTFTYLSPLLQEVTGFKANTVTI 256
Cdd:cd17333 160 YLLLAILILLtLFPELPSARNPQQSVGAFSASASRLLRNPSIILGalalfLYVGAETAFSSWVPSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 257 ILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYvvmlAER 336
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSL----GIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447012635 337 FVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVIL 390
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
20-391 |
8.11e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 8.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 20 ALLALAISAFGIGttefVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNG 99
Cdd:cd17477 1 LLLSVALLGLGSG----LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 100 IAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQfGWrTSFLAI 179
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GA-LPFLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 180 VVIGIIALIANSiLIPSNMKKGASVSFRDQFKLITNGRLLLVfiiTALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILL 259
Cdd:cd17477 155 AVLLLLALVPLL-LTRRAAPEIEEAESISLRRLLRIAPLALL---GAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 260 VYGIAIAIGNVIGGKLSNH-NPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPglqVYVVMLAERFV 338
Cdd:cd17477 231 AFVLGGLLLQWPLGWLADRfDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT---LALALAGDRLP 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 447012635 339 PSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILT 391
Cdd:cd17477 308 GDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
83-396 |
9.07e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 53.76 E-value: 9.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 83 RKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALshGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPI 162
Cdd:cd17472 61 RKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 163 GTFIGQQFGWRTSFLAIVVIGIIALIANSILIP--SNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLS 240
Cdd:cd17472 139 GPLLAAHLGVSGLFLITAILSLVSLLILLFFVPdpPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 241 PLLQEVTGFKANtvtiILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAG-LITIILMGLFA 319
Cdd:cd17472 219 LLLTQLGGGKGQ----LWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATsLWLLIIGLIIF 294
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447012635 320 FMNVPGLQVYVVMLAERFVPS-AVDVASAINIAAFNAGIALGAYLGGIVTNSLGlIHTAWVGGIMVVGAVILTAWSMT 396
Cdd:cd17472 295 FIGFNLLEALLPSLVSKIAPKeYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLG-YSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-189 |
2.43e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 15 RRSIFALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIF 94
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 95 IIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRT 174
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*
gi 447012635 175 SFLAIVVIGIIALIA 189
Cdd:cd06173 365 VFLLAGALLLLAALL 379
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
43-342 |
2.85e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 52.27 E-value: 2.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 43 PSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHG 122
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 123 VFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFL--AIVVIGIIALIA------NSILI 194
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYvgGVGPLLLVPLLMrwlpesRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 195 PSNMKKGASVSFRDQFKLITNGRLLLVFIitalGYGGTFVTFTYLS---PLLQEVTGFKANTVTIILLVYGIAIAIGNVI 271
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGEGRATATLLLWI----SYFFTLIVLYFLLnwlPSLLVGQGLSRSQAGLVQIAFNIGGALGSLL 274
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447012635 272 GGKLSNHnpIRALFYMFFIQAIILFVLTFTApfKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAV 342
Cdd:PRK11551 275 IGALMDR--LRPRRVVLLIYAGILASLAALA--AAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQV 341
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
81-390 |
1.00e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 50.24 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 81 MSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIisalshgVFMSIGSTIAAAL----------VPENKRASAIAIMFT 150
Cdd:cd17471 60 GDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGV-------VLLSLGAAAFPQLfalareyadrSSGRDATLFNSVLRA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 151 GVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPS-NMKKGASVSFRDQFKLITNGRLLLVFIITALGY 229
Cdd:cd17471 133 AFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSvKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 230 GGTFVTFTYLSPLLQEVTGFKANTVTIILlvyGIAIAIGNVI---GGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKV 306
Cdd:cd17471 213 AANSMYIIAMPLYVTNELGGSESWVGLLF---GLAAALEIPImllAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLW 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 307 AGLITIILMGLF--AFMNVPglqvyvVMLAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVGGIMV 384
Cdd:cd17471 290 QLIALQLLNAIFigITAGLG------ISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLA 363
|
....*.
gi 447012635 385 VGAVIL 390
Cdd:cd17471 364 LLALVL 369
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
42-233 |
2.04e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 49.53 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIIsalsH 121
Cdd:PRK11102 14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFL----H 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALV----PENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSN 197
Cdd:PRK11102 90 GLAAAAASVVINALMrdmfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 447012635 198 MKKGA------SVSFRDQFKLITNGRLLLVFIITALGYGGTF 233
Cdd:PRK11102 170 LPKERrqpfhlRTTIRNFASLFRHKRVLGYMLASGFSFAGMF 211
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
56-188 |
4.11e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 48.35 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 56 AGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAAL 135
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 447012635 136 VPENKRASAIAIMFTGVTVATITGAPIGTFIGQqfgWRTSFLAIVVIGIIALI 188
Cdd:cd17317 107 VGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLL 156
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
42-258 |
7.01e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 47.71 E-value: 7.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:PRK10473 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAiMFTGVTVATITGAP-IGTFIGQQFGWRTSFLAIVVIGIIALIANSILI----PS 196
Cdd:PRK10473 106 GCCYVVAFAILRDTLDDRRRAKVLS-LLNGITCIIPVLAPvLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILketrPA 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447012635 197 NMKKGASVSFRDQFKLItNGRLLLVFIITALGYgGTFVTFTYLSP-LLQEVTGFKANTVTIIL 258
Cdd:PRK10473 185 RAPAASSKPRENSESLL-NRFFLSRLVITTLSV-TVILTFVNTSPvLLMEQMGFSRGEYAIIM 245
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
40-373 |
8.62e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 47.60 E-value: 8.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 40 GLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISAL 119
Cdd:cd17331 21 PVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 120 SHGvfMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIPSNMK 199
Cdd:cd17331 101 MHA--MQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 200 ------KGASVSFRDQFKLITNGRLL------LVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAI 267
Cdd:cd17331 179 skrekeAKESASPPSVFNLKEILRLLrlpgvaFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 268 GNVIG-GKLSNH-NPIRALFYMFFIQAIILFVLTFtAPFKVAGLITIILMGLFAFMnvpglqVYVV---MLAERFVPSAV 342
Cdd:cd17331 259 VQGLLvGPLTKRfGERSLLKLSVALLAIGYLLLAF-VTTVWQLLVLLLPLVIGGSV------LYTVitsLLTKAVPPEDT 331
|
330 340 350
....*....|....*....|....*....|.
gi 447012635 343 DVASAINIAAFNAGIALGAYLGGIVTNSLGL 373
Cdd:cd17331 332 GTALGLSHALFSLVRTVSPTIGGALLQAYGF 362
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
41-301 |
1.12e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.84 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISals 120
Cdd:cd17390 18 LLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPL--- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 hGVF---MSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQqfgWRTSFLAIVVIGIIALIANSILIpsn 197
Cdd:cd17390 95 -GIFkhtQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAE---TDGGFYYVALLCSAIFILNAGLV--- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 198 mkkgasvsfrdqfkLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGG---K 274
Cdd:cd17390 168 --------------WFLLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGrilK 233
|
250 260
....*....|....*....|....*..
gi 447012635 275 LSNHNPIRALFYMFFIQAIILFVLTFT 301
Cdd:cd17390 234 LYKNNEYLLLLHSFILLALSLLGLALA 260
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
41-392 |
1.48e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.81 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLT--ANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISA 118
Cdd:cd17335 19 FLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALAdrFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 119 LSHGVFMSIGSTIAAALVPENKRASAIAIMFTGV---TVATITGAPIgTFIGQQFGWRTSFLAIVVIGIIALIANSILIP 195
Cdd:cd17335 99 FFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIgfgIAALLVGILI-DRSSTYKNYTIAFYVFAVLMLLALLLALKFPF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 196 SNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVTGfkantvtiILLVYGIAIAIGNV----- 270
Cdd:cd17335 178 RPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGG--------SKTLIGLLWTVGVVseipf 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 271 --IGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVAGLITIILMGL-FAFMNVPGLQvYVVMLAErfvPSAVDVASA 347
Cdd:cd17335 250 ffFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLtFALVWAAAVS-YASAAAP---PGLRATAQG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447012635 348 INIAAFN-AGIALGAYLGGIVTNSLGLIHTAWVGGIMVVGAVILTA 392
Cdd:cd17335 326 LLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
55-337 |
2.20e-05 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 46.21 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 55 TAGLTVSLYALGVAF-----GAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFT--------VLLIARIISALSH 121
Cdd:cd17368 36 FASLLLTFATFGVGFfmrpiGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIG--------QQFGWRTSFLAIVVIGIIAL-----I 188
Cdd:cd17368 116 GGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSltltaealAEWGWRIPFFIGLLIIPLGLwlrrsL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 189 ANSILIPSNMKKGASVSFrdqFKLITNGR--LLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIA 266
Cdd:cd17368 196 EETEAFLERKARPTRREL---FALLANNRriILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANF 272
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447012635 267 IGNVIGGKLSNHNPIRALFY----MFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMnvpGLQVYVVMLAERF 337
Cdd:cd17368 273 IWAPLGGALSDRIGRRPVLLvitlAALVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGM---YGGAMVVALVELF 344
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
52-189 |
2.96e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 45.73 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 52 SVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVfMSIGSTI 131
Cdd:cd17389 62 SVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGN-VSLSTAI 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 447012635 132 AAALVPENKRASAIAImftgVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIA 189
Cdd:cd17389 141 VADVTSPKKRSKGMAL----IGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPALFA 194
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
26-393 |
3.09e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.73 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 26 ISAFGIGTTEFVSVGLLPSISEDLHVSVTTaGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVAT 105
Cdd:pfam00083 19 IGAFLTLIDFFKNFGLSKSVSSLAALSVLS-GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAK 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 106 ---SFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTF---IGQQFGWRTSFLAI 179
Cdd:pfam00083 98 gkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGlnkTSNSDGWRIPLGLQ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 180 VVIGIIALI--------------------ANSILIPSNMKKGASVSFRDQFKLI----------------TNGRLLLVFI 223
Cdd:pfam00083 178 LVPALLLIIgllflpesprwlvekgrleeAREVLAKLRGVPDVDRELDEIKDSLeagqeaekaswkelfsTKTRRQRLLI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 224 ITALGYGGTFVT---FTYLSPLLQEVTGFKANTVTIIllVYGIAIAIGNVIGGKLSNHNPIRALFY--------MFFIQA 292
Cdd:pfam00083 258 GVMLQIFQQLTGinaIFYYSTTIFENLGLSDSFLVTI--IVGVVNFVFTFIAIFLVDRFGRRPLLLlgaagmaiCFVILG 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 293 IILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVmLAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLG 372
Cdd:pfam00083 336 IVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVI-VSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIG 414
|
410 420
....*....|....*....|.
gi 447012635 373 LIHTAWVGGIMVVGAVILTAW 393
Cdd:pfam00083 415 LGYTFFIFAGLLVLFIIFVFF 435
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
99-353 |
3.19e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 45.75 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 99 GIAAvatsFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRA--------SAIAIMFTGVTVATITGAPIGTFIGQQF 170
Cdd:cd17367 97 GIWA----PIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGfyssfqyvTLIGGQLLALGVLLVLQHTLGEDQMAAW 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 171 GWRTSFLAIVVIGIIALIANSILIPSNMKKGASVSFRDQFKLITNGR-----LLLVFIITALGYGGTFVTFTYLSPLLQE 245
Cdd:cd17367 173 GWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRrhpreLLLVVGLTAGGTLAFYTWTTYLQKFLVN 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 246 VTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTA------PFKVAGLITIILMGLFA 319
Cdd:cd17367 253 TAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAldhtdsPYTAFALVLVGLVFLSG 332
|
250 260 270
....*....|....*....|....*....|....
gi 447012635 320 FMNVPGLqVYVVMLAERFVPSAVDVASAINIAAF 353
Cdd:cd17367 333 YTSINAV-VKAELFPTHVRALGVGLPYALAVAIF 365
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-189 |
1.19e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.71 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 21 LLALAISAFGIGTTEFVSVGLLPSI-SEDLHVSVTTAGLTVSLYALGVAFG---APVLTSLTANMSRKTLLMWIMIIFII 96
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYlKQARGFSLKQVGLLAAIPFLAGAIGmilGGRLSDRLLRGARRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 97 GNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIM-FTGVTVATITGAPIGTFIGQQFGWRTS 175
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLInSGGNLGGFVAPLLIGYLVDATGSYTAA 340
|
170
....*....|....
gi 447012635 176 FLAIVVIGIIALIA 189
Cdd:cd17319 341 FLFLAAVALLAALL 354
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
27-391 |
1.68e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 43.51 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 27 SAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPV-LTSLTANMSRKTLLMWIMIIFIIGNGIA-AVA 104
Cdd:pfam06779 1 LTVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLaSFAWRHGASRLRPALLAGLLATVLLLLAmAAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 105 TSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQF-GWRTSFLAIVVIG 183
Cdd:pfam06779 81 SSFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGlGGSSLWYGAGVLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 184 IIALIANSILIPSNMKKGASVSFRDQFKLITN---GRLLLVFIITALGYggtFVTFTYLSPLLQEVTGFKANTVTIILLv 260
Cdd:pfam06779 161 AVLTLAVFPLLPRRAPRHASAPAPAAKPLQRSlplWILTLAYGLAGFGY---IITATFLPAMARDGFGGPAAAALFWSL- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 261 YGIAIAIGNVIGGKLSNHNPIR-ALFYMFFIQAIILFvLTFTAPFKVAGLITIILMGLFAFMNVPglqvYVVMLAERFVP 339
Cdd:pfam06779 237 FGLAAALGVLVWLRAAKRWGTRpALTAALLIQALGVL-LSLLSPSPAGLAVSSLLFGGTFMAITS----LVMQLARELAP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447012635 340 SAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIH--TAWVGGIMVVGAVILT 391
Cdd:pfam06779 312 PAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTpaLLLAAAALVLAALIVL 365
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
87-196 |
1.85e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 43.31 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 87 LMWIMIIFIIgngIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFI 166
Cdd:cd17380 72 ALWSLATLLT---PLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLL 148
|
90 100 110
....*....|....*....|....*....|
gi 447012635 167 GQQFGWRTSFLAIVVIGIIALIANSILIPS 196
Cdd:cd17380 149 LEYYGWPSVFYFFGLLGLLWALVWLIYLPP 178
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-203 |
2.19e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.95 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 28 AFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVAT-S 106
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgS 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 107 FTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFG-WRTSFLAIVVIGII 185
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALV 374
|
170
....*....|....*...
gi 447012635 186 ALIANSILIPSNMKKGAS 203
Cdd:COG2223 375 ALVLTLLLYRRPRRAAAA 392
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
16-202 |
2.20e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 43.28 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 16 RSIFALLALAISAFGIG-TTEFVSVGLLpSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIF 94
Cdd:PRK15403 13 ATLFFPMALILYDFAAYlTTDLIQPGII-NVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 95 IIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRT 174
Cdd:PRK15403 92 TLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKV 171
|
170 180
....*....|....*....|....*...
gi 447012635 175 SFLAIVVIGIIALIANSILIPSNMKKGA 202
Cdd:PRK15403 172 LFAIIAVMGLIAFVGLLLAMPETVKRGA 199
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
58-173 |
2.67e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 42.99 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 58 LTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGN---GIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAA 134
Cdd:cd17432 54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAilmGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGE 133
|
90 100 110
....*....|....*....|....*....|....*....
gi 447012635 135 LVPENKRASaiaimfTGVTVATITGapIGTFIGQQFGWR 173
Cdd:cd17432 134 SAPKNLRGA------VGLVPAIFIT--LGILLGQVLGLR 164
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
56-196 |
2.69e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 56 AGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAAL 135
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEF 208
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447012635 136 VPENKRASAIAIMFTGVTVATITGAPIGTFIGQqfgWRTSFLAIVVIGIIALIANSILIPS 196
Cdd:TIGR00898 209 LPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFFLLSWFVPES 266
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
47-390 |
3.59e-04 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 42.43 E-value: 3.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 47 EDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIA-RIISALSHGVFM 125
Cdd:cd17422 31 SYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYLTiGIISGLGYCFTF 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 126 SIGSTIAAALVpENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILipsnmkkgasvs 205
Cdd:cd17422 111 LPTVTILSQYF-KKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGALQLNIVVCGALL------------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 206 frdqfKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVtGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALf 285
Cdd:cd17422 178 -----RVLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSL-GIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKI- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 286 YMFFIQAIILFVLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVDVASAINIAAFNAGIA--LGAYL 363
Cdd:cd17422 251 YIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALGVYVFIQSIAglAGPPL 330
|
330 340
....*....|....*....|....*....
gi 447012635 364 GGIVTNSLGLIHTAW--VGGIMVVGAVIL 390
Cdd:cd17422 331 GGVLVDWTQNYGSAFysCAAGMALGAVFL 359
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
18-188 |
4.57e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.18 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 18 IFALLALAISAFGIGTTEFVSVGLLPSISED----LHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMII 93
Cdd:cd17358 1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 94 FIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMftgvTVATITGAPIGTFIGQQFGWR 173
Cdd:cd17358 81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLN----QLLVNIGILLGYVLGSFLPWR 156
|
170
....*....|....*
gi 447012635 174 TSFLAIVVIGIIALI 188
Cdd:cd17358 157 TLALIGAIPPVVFLI 171
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
57-195 |
6.68e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.47 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 57 GLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGI-AAVATSFTVLLIARIISALSHGVFMSIGSTIAAAL 135
Cdd:cd17356 48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEV 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447012635 136 VPENKRASAIAIMFTGVTVATITGAPI--GT-FIGQQFGWRTSfLAIVVIGIIALIANSILIP 195
Cdd:cd17356 128 APKHIRGTLVSLYQLAITIGILVAYCInyGThKLDGSAQWRIP-LGLQIVWGLLLLIGMFFLP 189
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
91-320 |
1.30e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 91 MIIFIIGNGIAAVA--TSFTVLLIARIISALSHGVFMSIGSTIA----AALVPE-----NKRASAIAIMFTGVTVATITG 159
Cdd:cd17332 73 LLWGAIPLALLFVLlfTTPDGSGTGKLIYALITYILLDLLYTLVnipyTALIPEltddpEERTSLTSWRMFFATIGGLLV 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 160 A----PIGTFIGQQFGWRTSFLAIVVIGIIALIANSIL-------IPSNMKKGASVSFRDQFKLITNGRLLLVFIITALG 228
Cdd:cd17332 153 TvlppPLVAYFGGGNASRGYFLTALIIGIIGIILLLICffgtrerVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLL 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 229 YG-GTFVTFTYLSPLLQEVTGFKANTVtIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTFTAPFKVA 307
Cdd:cd17332 233 YFlAFNIVNTVLVYYFKYVLGGRAELV-LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNL 311
|
250
....*....|...
gi 447012635 308 GLITIILMGLFAF 320
Cdd:cd17332 312 VLILVLAVLAGIG 324
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
221-389 |
1.52e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 40.30 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 221 VFIITALGYGGTFV---TFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNH-NPIRALFYMFFIQAIILF 296
Cdd:cd17345 4 VFLGIFIGYAGYYLvrnNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRsNPKRFLAIGLILSAIINI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 297 VLTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVVMLAERFVPSAVDVASAINIAAFNAGialGAYLGGIVTNSLGLIHT 376
Cdd:cd17345 84 LIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVG---GGLVGPLAGLGLAIFGD 160
|
170
....*....|...
gi 447012635 377 AWVGGIMVVGAVI 389
Cdd:cd17345 161 GWWRGAFIFPAII 173
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-390 |
1.82e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 221 VFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFVLTF 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 301 TAPFKVAGLITIILMGLFAFMNVPGLQVyvvMLAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTAWVG 380
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALA---LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170
....*....|
gi 447012635 381 GIMVVGAVIL 390
Cdd:pfam07690 158 AILSLLAAVL 167
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
83-189 |
2.16e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 39.89 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 83 RKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALV--PENKRASAIAIMftGVTVATITGA 160
Cdd:PRK11652 72 RRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYegTQLRHANSLLNM--GILVSPLLAP 149
|
90 100
....*....|....*....|....*....
gi 447012635 161 PIGTFIGQQFGWRTSFLAIVVIGIIALIA 189
Cdd:PRK11652 150 LIGGLLTTLFGWRACYLFLLLLGAGVTFS 178
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
41-312 |
2.88e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 41 LLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIAR-IISAL 119
Cdd:cd17352 25 LFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 120 SHGvFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILipsnmk 199
Cdd:cd17352 105 GLG-LIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 200 kgasvsfrdqfKLITNGRLLLVFIITALGYGGTFVTFTYLSPLLQEVtGFKANTVTIILLVYGIAIAIGNVIGGKLSNHN 279
Cdd:cd17352 178 -----------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESDAAFLLSIIGISDIVGRILLGLLADKP 245
|
250 260 270
....*....|....*....|....*....|....
gi 447012635 280 PIRALFYMFFIQAII-LFVLTFTAPFKVAGLITI 312
Cdd:cd17352 246 RIGRLYLYIFTLLILgLSLLAFPLATTYVGLIVF 279
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
17-172 |
2.90e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 17 SIFALLALAISAFGIGTteFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIfii 96
Cdd:TIGR01299 167 ALFFVLGLALMADGVEV--FVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSV--- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 97 gNGIAAVATSFT----VLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGW 172
Cdd:TIGR01299 242 -NGFFAFFSSFVqgygFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
44-211 |
3.35e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 39.49 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 44 SISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISAL---S 120
Cdd:PRK11043 31 AIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVgvcS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 121 HGVfmsigstIAAALVPENKRASAIAIMFtgvtvATITG--------API-GTFIGQQFGWRTSFLAIVVIGIIALIANS 191
Cdd:PRK11043 111 AAV-------IWQALVIDRYPAQKANRVF-----ATIMPlvalspalAPLlGAWLLNHFGWQAIFATLFAITLLLILPTL 178
|
170 180
....*....|....*....|...
gi 447012635 192 ILIPSN---MKKGASVSFRDQFK 211
Cdd:PRK11043 179 RLKPSKkarKQSQDALTFKQLLK 201
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
82-318 |
3.58e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 82 SRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAP 161
Cdd:cd17370 63 KRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 162 IGTFI--GQQFGWRTSFLAIVVIGIIALIANSILIPSNMKKGASVSFRDQFKLITNGRLLLVFIITALGYGGTFVTFTYL 239
Cdd:cd17370 143 LAALLlyLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFL 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 240 SPLLQEVtGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYM-FFIQAIILFVLTFTAPFKVAgLITIILMGLF 318
Cdd:cd17370 223 ILRAQEL-GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILgYLSLALAYLGFALGSSLWLL-LLGFILWGLY 300
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
217-397 |
4.30e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.08 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 217 RLLLVFIITALGYGGTFVTFTYLSPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILF 296
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 297 VLTFTAPFKVAGLITIILMGLFAFMNVPGLqvyVVMLAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHT 376
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAA---LKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180
....*....|....*....|.
gi 447012635 377 AWVGGIMVVGAVILTAWSMTL 397
Cdd:COG2271 167 FLILGLPGLLLALLRFWLLAL 187
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-193 |
4.41e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.13 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 49 LHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMwimIIFIIGNGIAAVATSFTVLLIARIISALSHGVFMSIG 128
Cdd:cd17353 244 AGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS---IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGG 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447012635 129 STIAAALVPEN---KRASAI-AIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSIL 193
Cdd:cd17353 321 FALFPALTADFfgtKNAGTNyGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
42-195 |
4.78e-03 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 38.94 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 42 LPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGNGIAAVATSFTVLLIARIISALSH 121
Cdd:PRK10504 33 LPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGG 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447012635 122 GVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWRTSFLAIVVIGIIALIANSILIP 195
Cdd:PRK10504 113 AMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMP 186
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
19-188 |
5.87e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 5.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 19 FALLALAISAFGIGTtefVSVGLLPSISEDLHvSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIFIIGN 98
Cdd:cd06179 1 AALCLAYFAQLFGVT---LPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 99 GIAAVATSFTVLLIARIISALSHGVfMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQF--GWRTSF 176
Cdd:cd06179 77 IVAGTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIF 155
|
170
....*....|..
gi 447012635 177 LAIVVIGIIALI 188
Cdd:cd06179 156 YINAIFNALALI 167
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-395 |
6.28e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 6.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 218 LLLVFIITALGYGGTFVTFTYLsPLLQEVTGFKANTVTIILLVYGIAIAIGNVIGGKLSNHNPIRALFYMFFIQAIILFV 297
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPAL-PLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 298 LTFTAPFKVAGLITIILMGLFAFMNVPGLQVYVvmlAERFVPSAVDVASAINIAAFNAGIALGAYLGGIVTNSLGLIHTA 377
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALI---ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*...
gi 447012635 378 WVGGIMVVGAVILTAWSM 395
Cdd:COG2814 168 LVNAVLALLALLLLLRLL 185
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-189 |
8.53e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 37.92 E-value: 8.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 15 RRSIFALLALAISAFGIGTTEFVSVGLLPSISEDLHVSVTTAGLTVSLYALGVAFGAPVLTSLTANMSRKTLLMWIMIIF 94
Cdd:cd17477 184 RRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447012635 95 IIGN-GIAAVATSFTVLLIARIISALSHGVFMSIGSTIAAALVPENKRASAIAIMFTGVTVATITGAPIGTFIGQQFGWR 173
Cdd:cd17477 264 ALAAlLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH 343
|
170
....*....|....*.
gi 447012635 174 TSFLAIVVIGIIALIA 189
Cdd:cd17477 344 GLFLFLAAVALLFLLF 359
|
|
| |
