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Conserved domains on  [gi|447028033|ref|WP_001105289|]
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MULTISPECIES: nitroreductase family protein [Bacillus]

Protein Classification

nitroreductase family protein( domain architecture ID 10002498)

nitroreductase family protein may catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor

CATH:  3.40.109.10|2.20.180.10
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  29078300|7601851
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 6-211 2.69e-46

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 150.39  E-value: 2.69e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   6 FKEVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIeqmtwdalhklaakaaengeeka 85
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERL----------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  86 GKLLTRSFGPYATafsEAPVLIVCLATSYESKFREkifdpiafvpdsvwEEEGIKSSCLAAQNLMLAAHAKGLGTCPMTG 165
Cdd:COG0778   58 AEALAEANQEWVA---DAPVLIVVCADPDRSEKVP--------------ERYALLDAGIAAQNLLLAARALGLGTCWIGG 120

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 447028033 166 pvlLAQDELRQYLQIAPEKQINMVISLGFPKDKPKKLPRKEVDEIT 211
Cdd:COG0778  121 ---FDPEKVRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEVV 163
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 6-211 2.69e-46

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 150.39  E-value: 2.69e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   6 FKEVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIeqmtwdalhklaakaaengeeka 85
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERL----------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  86 GKLLTRSFGPYATafsEAPVLIVCLATSYESKFREkifdpiafvpdsvwEEEGIKSSCLAAQNLMLAAHAKGLGTCPMTG 165
Cdd:COG0778   58 AEALAEANQEWVA---DAPVLIVVCADPDRSEKVP--------------ERYALLDAGIAAQNLLLAARALGLGTCWIGG 120

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 447028033 166 pvlLAQDELRQYLQIAPEKQINMVISLGFPKDKPKKLPRKEVDEIT 211
Cdd:COG0778  121 ---FDPEKVRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEVV 163
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 7-210 2.76e-44

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 144.69  E-value: 2.76e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   7 KEVIHGRRSVRKFTDQ-EVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTWDalhklaakaaengeeka 85
Cdd:cd02137    1 LEVIKSRRSVRNFDPDhKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYN----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  86 gklltRSFGPYATAfseapVLIVClatsyeskfrekifdpiafvpdsvweeeGIKSSCLAAQNLMLAAHAKGLGTCPMTG 165
Cdd:cd02137   64 -----QPQVTTASA-----VILVL----------------------------GDLNAGLAAMNLMLAAKAKGYDTCPMGG 105

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 447028033 166 PVLlaqDELRQYLQIAPEKQINMVISLGFPKDKPKKLPRKEVDEI 210
Cdd:cd02137  106 FDK---EKVAELLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 12-194 5.56e-36

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 124.43  E-value: 5.56e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   12 GRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTWDALHKLAAKAaengEEKAGKLLTR 91
Cdd:pfam00881   3 QRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAA----LLLLLRRDAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   92 SFGPYATAFSEAPVLIVCLATSYESKFRekifdpiafvPDSVWEEEGIKSSCLAAQNLMLAAHAKGLGTCPMTGPvllAQ 171
Cdd:pfam00881  79 LKLLLQDFLRGAPVLIVITASLSTYLRK----------AAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGF---DA 145

                         170       180
                  ....*....|....*....|...
gi 447028033  172 DELRQYLQIAPEKQINMVISLGF 194
Cdd:pfam00881 146 AAVRELLGLPDDERLVGLIAVGY 168
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
8-66 6.64e-05

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 42.65  E-value: 6.64e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447028033   8 EVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMT 66
Cdd:PRK10765   6 ELILSHRSIRHFTDEPISEAQREAIINAARAASSSSFLQCSSIIRITDKALREALVELT 64
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 6-211 2.69e-46

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 150.39  E-value: 2.69e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   6 FKEVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIeqmtwdalhklaakaaengeeka 85
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERL----------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  86 GKLLTRSFGPYATafsEAPVLIVCLATSYESKFREkifdpiafvpdsvwEEEGIKSSCLAAQNLMLAAHAKGLGTCPMTG 165
Cdd:COG0778   58 AEALAEANQEWVA---DAPVLIVVCADPDRSEKVP--------------ERYALLDAGIAAQNLLLAARALGLGTCWIGG 120

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 447028033 166 pvlLAQDELRQYLQIAPEKQINMVISLGFPKDKPKKLPRKEVDEIT 211
Cdd:COG0778  121 ---FDPEKVRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEVV 163
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 7-210 2.76e-44

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 144.69  E-value: 2.76e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   7 KEVIHGRRSVRKFTDQ-EVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTWDalhklaakaaengeeka 85
Cdd:cd02137    1 LEVIKSRRSVRNFDPDhKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYN----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  86 gklltRSFGPYATAfseapVLIVClatsyeskfrekifdpiafvpdsvweeeGIKSSCLAAQNLMLAAHAKGLGTCPMTG 165
Cdd:cd02137   64 -----QPQVTTASA-----VILVL----------------------------GDLNAGLAAMNLMLAAKAKGYDTCPMGG 105

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 447028033 166 PVLlaqDELRQYLQIAPEKQINMVISLGFPKDKPKKLPRKEVDEI 210
Cdd:cd02137  106 FDK---EKVAELLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 10-194 2.10e-42

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 140.88  E-value: 2.10e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  10 IHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTWDALHKLAAKAAENGEEKAGKLl 89
Cdd:cd20610    1 IKKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKIGISIKKKNEEIARLLEKVFAEKPIRF- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  90 tRSFGPYATAFSEAPVLIVCLATSYESKFREKifdpiafvpdsvweeEGIKSSCLAAQNLMLAAHAKGLGTCPMTGPvLL 169
Cdd:cd20610   80 -RKFRRFFTLFGGAPVLVVVYTEPYKPPEERK---------------PDLQSVSAAIQNLLLAAHALGLGTCWMTGP-LY 142

                        170       180
                 ....*....|....*....|....*
gi 447028033 170 AQDELRQYLQIAPEKQINMVISLGF 194
Cdd:cd20610  143 AEDEIEEILEIPDDKELVAVTPLGY 167
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 12-194 5.56e-36

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 124.43  E-value: 5.56e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   12 GRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTWDALHKLAAKAaengEEKAGKLLTR 91
Cdd:pfam00881   3 QRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAA----LLLLLRRDAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   92 SFGPYATAFSEAPVLIVCLATSYESKFRekifdpiafvPDSVWEEEGIKSSCLAAQNLMLAAHAKGLGTCPMTGPvllAQ 171
Cdd:pfam00881  79 LKLLLQDFLRGAPVLIVITASLSTYLRK----------AAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGF---DA 145

                         170       180
                  ....*....|....*....|...
gi 447028033  172 DELRQYLQIAPEKQINMVISLGF 194
Cdd:pfam00881 146 AAVRELLGLPDDERLVGLIAVGY 168
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 9-211 1.93e-33

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 117.30  E-value: 1.93e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   9 VIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMN--REKIKEIeqmtwdalhklaakaaengeekag 86
Cdd:cd02136    1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGkaRERLKKA------------------------ 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  87 klltrSFGpyatafseAPV-LIVCLATSYESKFrekIFDpiafvpdsvweeegiksSCLAAQNLMLAAHAKGLGTCPMtG 165
Cdd:cd02136   57 -----FFG--------APVaLFLTMDKVLGPWS---WFD-----------------LGAFLQNLMLAAHALGLGTCPQ-G 102

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 447028033 166 PVLLAQDELRQYLQIAPEKQINMVISLGFPkDKPKKL-----PRKEVDEIT 211
Cdd:cd02136  103 ALAGYPDVVRKELGIPDDEELVCGIALGYP-DPDAPVnqfrtPREPLEEFV 152
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 10-194 2.61e-32

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 113.93  E-value: 2.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  10 IHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTWdalhklaakaaengeekagkll 89
Cdd:cd02062    1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAA---------------------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  90 trsfgPYATAFSEAPVLIVCLAtsyeskfrekifdpiafvPDSVWEEEGIKSSCLAAQNLMLAAHAKGLGTCPMTGPvLL 169
Cdd:cd02062   59 -----PNQKFIAGAPVVIVVVA------------------DPDKSRPWALEDAGAAAQNLLLAAAALGLGSCWIGGF-DF 114

                        170       180
                 ....*....|....*....|....*
gi 447028033 170 AQDELRQYLQIAPEKQINMVISLGF 194
Cdd:cd02062  115 REDKVRELLGIPENLRPVALIAIGY 139
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 8-200 3.72e-28

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 103.77  E-value: 3.72e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   8 EVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTwdalhklaakaaengeekagk 87
Cdd:cd02151    1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECK--------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  88 lltrsfgPYATAF-SEAPVLIVCLATSYESKfrekifdpiafvpdsVWEEEGikssCLAAQNLMLAAHAKGLGTC----- 161
Cdd:cd02151   60 -------PHGSAFlKGAPAAIVVLADTEKSD---------------TWIEDA----SIAATYIQLAAESLGLGSCwiqir 113

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 447028033 162 -PMTGPVLLAQDELRQYLQIAPEKQINMVISLGFPKDKPK 200
Cdd:cd02151  114 nRETQDGKTAEEYVRELLGIPENYRVLCIIALGYPDEEKP 153
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 6-210 5.47e-28

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 103.70  E-value: 5.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   6 FKEVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKeieqmtwdalhklaakaaengeeka 85
Cdd:cd02139    1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKE------------------------- 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  86 gKLLTRSFGpyATAFSEAPVLIVCLATSYESKFREKIfdpIAFVPDsvweeegiksSCLAAQNLMLAAHAKGLGTCPMtG 165
Cdd:cd02139   56 -KLAEAANG--QKFIAEAPVVIVACADPSESGMGCGK---PYYLVD----------VAIAMEHLVLAATEEGLGTCWI-G 118

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 447028033 166 pvLLAQDELRQYLQIAPEKQINMVISLGFPKDKPKKLPRKEVDEI 210
Cdd:cd02139  119 --AFDEDKVKEILGIPEEYRVVALTPLGYPAEEPPPRPRKPLEEI 161
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 10-200 1.58e-27

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 102.29  E-value: 1.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  10 IHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIeqmtwdalhklaakaaengeekagkll 89
Cdd:cd02150    1 ILTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKI--------------------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  90 tRSFGPYATAFSEAPVLIVCLAtsyeskfrekifDPIAFVPDSVWEEEgikssCLAA-QNLMLAAHAKGLGTC-----PM 163
Cdd:cd02150   54 -AEAHPYGKMLKEAPLAIVVCG------------DPSKEKAPGYWVQD-----CSAAtENILLAAHALGLGAVwlgvyPF 115

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 447028033 164 TGPVllaqDELRQYLQIaPEKQINM-VISLGFPKDKPK 200
Cdd:cd02150  116 EERV----KAIREILNI-PENIIPFcVIALGYPAEEKE 148
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 8-194 4.01e-26

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 98.18  E-value: 4.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   8 EVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEieqmtwdalhklaakaaengeekagk 87
Cdd:cd20608    2 EAIKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSE-------------------------- 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  88 lLTRSFGPYATAFSEAPVLIVCLAtsyeskfrekifDPiafvPDSvWEEEGIK----SSCLAAQNLMLAAHAKGLGTCPM 163
Cdd:cd20608   56 -LAKKESPSNGWLKDAPVIIVVCA------------DP----KDS-GWLNGQNyylvDAAIAMQNLMLAATDLGLGTCWI 117

                        170       180       190
                 ....*....|....*....|....*....|...
gi 447028033 164 TgpvllAQDE--LRQYLQIAPEKQINMVISLGF 194
Cdd:cd20608  118 G-----AFDEkkVKEILGIPENIRVVALTPLGY 145
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 10-208 2.22e-24

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 94.85  E-value: 2.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  10 IHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMT--WdalhklAAKAAENGEEKAGK 87
Cdd:cd02143    2 LRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLAELVidW------MRELIKEDPELAGK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  88 LLtrsFGPYATAFSE--------APVLIVCLATSyeskfrekifdpiafvpDSVWEEEgikSSCLAAQNLMLAAHAKGLG 159
Cdd:cd02143   76 LF---LDGIVAAWEKgidvilrgAPHLVVAHAPK-----------------DAPTPPV---DCAIALTYLELAAPSLGLG 132

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 447028033 160 TCpMTGPVLLAQD---ELRQYLQIAPEKQINMVISLGFPKDKPKKLP-RKEVD 208
Cdd:cd02143  133 TC-WAGFFTAAANnypPLREALGLPEGHKVGGAMMLGYPKYKYHRIPpRKPAR 184
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 5-161 2.03e-20

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 83.21  E-value: 2.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   5 DFKEVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTwdalhklaakaaengeek 84
Cdd:cd20609    1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKAT------------------ 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  85 agklltrsfgPYataFSEAP-VLIVClatsyeskfrekifdpiaFVPDSVWE-EEGIKSSC-----LAAQNLMLAAHAKG 157
Cdd:cd20609   63 ----------PR---FFGAPlVIVVC------------------YDKDESWKrPYDGKDSGdidaaIVATHMMLAATELG 111


                 ....
gi 447028033 158 LGTC 161
Cdd:cd20609  112 LGTC 115
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 13-210 3.06e-20

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 84.13  E-value: 3.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  13 RRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQmtwdalhKLAAKAAENGEEKAGKLLTRS 92
Cdd:cd02144    8 RRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIRE-------AAEEEEKEFYEKRMGEEWVWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  93 FGPYATAFS-----EAPVLIVCLATSY---ESKFREKIFdpiaFVPDSVWEEEGIkssclaaqnLMLAAHAKGLGT---C 161
Cdd:cd02144   81 LKPLGTNWEkpyltEAPYLIVVFKQKYgvlPDGKKKKHY----YNEESVGIAVGI---------LLAALHNAGLVTlthT 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 447028033 162 PMTGPvllaqdELRQYLQIAPEKQINMVISLGFPKD--KPKKLPRKEVDEI 210
Cdd:cd02144  148 PSPMP------FLRDLLGRPKNEKPLLLLPVGYPAEdaTVPDLKRKPLEEI 192
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 8-194 4.65e-20

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 83.04  E-value: 4.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   8 EVIHGRRSVRKFTDQE-VSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTwdalHKLAAKAAENGEEKAG 86
Cdd:cd02135    2 ELIKTRRSIRKFKLTGaPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLA----AAAAARAPGADPEKLE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  87 KLLTRsfgpyataFSEAPVLIVCLAtsyeskfreKIfDPIAFVPdsvwEEEGIKSSCLAAQNLMLAAHAKGLGTCPMTGP 166
Cdd:cd02135   78 KAREK--------ALRAPVVIAVVA---------KP-DEDPKVP----EWEQYAAVGAAVQNLLLAAHALGLGAVWRTGP 135

                        170       180
                 ....*....|....*....|....*...
gi 447028033 167 VLLAqDELRQYLQIAPEKQINMVISLGF 194
Cdd:cd02135  136 VTYD-PAVREALGLPEDERIVGFLYLGT 162
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 7-195 7.01e-17

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 75.43  E-value: 7.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   7 KEVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTwdalhklaakaaeNGEEKAG 86
Cdd:cd03370    2 KEAIESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAAA-------------YGQAQVT 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  87 klltrsfgpyatafsEAPVLIV-------CLAT---------SYESKFREKIFDPIAFVPDSVWEEE--GIKSSCLAAQN 148
Cdd:cd03370   69 ---------------SAPAVIViysdmedALANleetihpglSEERRQREAAGLRGAFGKMSVEQRGqwGLAQANIALGF 133

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 447028033 149 LMLAAHAKGLGTCPMTGpvlLAQDELRQYLQIAPEKQINMVISLGFP 195
Cdd:cd03370  134 LLLAAQSLGYDTSPMLG---FDPEKVKALLGLPEHVTIAALVALGKP 177
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 5-210 2.24e-15

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 70.36  E-value: 2.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   5 DFKEVIHGRRSVRKFTDQ-EVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMTWdalhklaakaaengee 83
Cdd:cd02149    1 NILELLNFRYATKKFDPNkKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPAAW---------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  84 kagklltrsFGpyATAFSEAPVLIVclatsyeskfrekifdpiaFVPDSVWEEegiKSSCLAAQNLMLAAHAKGLGTCPM 163
Cdd:cd02149   65 ---------FN--QPQIKDASHVVV-------------------FLAKKDWSA---KQTYIALGNMLLAAAMLGIDSCPI 111

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 447028033 164 TGpvlLAQDELRQYLQIAPEKQ-INMVISLGFPKDKPKKLPRKEVDEI 210
Cdd:cd02149  112 EG---FDPAKLDEILGLDEKGYkISVMVAFGYRSEEKLPKSRKPLEDV 156
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 9-210 5.96e-15

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 69.50  E-value: 5.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   9 VIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIkeieqmtwdalhklaakaaengEEKAGKL 88
Cdd:cd02138    1 LIAERWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPWRFVVARRDTEA----------------------FEKLLDL 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  89 LTRSFGPYAtafSEAPVLIVCLA-TSYESKFREK---IFDpiafvpdsvweeegiksSCLAAQNLMLAAHAKGLGTCPMT 164
Cdd:cd02138   59 LAEGNQSWA---KNAPVLIVVLAkTEFDHNGKPNryaLFD-----------------TGAAVANLALQATALGLVVHQMA 118

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 447028033 165 GpvlLAQDELRQYLQIAPEKQINMVISLGFPKDK---PKKL--------PRKEVDEI 210
Cdd:cd02138  119 G---FDPEKAKEALGIPDEYEPITMIAIGYPGDPeslPEKLlereeaprTRKPLSEI 172
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 8-204 3.12e-14

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 68.80  E-value: 3.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   8 EVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQmtwdalhklaakaaengeekagk 87
Cdd:cd02146    3 ETILNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAE----------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  88 lLTRSFGPYAtafsEAPV-LIVCLATSYESKFREK--IFDPIAFVPDSVWeeEGIKSSCLAAQNLMLAAHAKGLGTCPMt 164
Cdd:cd02146   60 -LAGNQPYVA----QAPVfLVFCADLYRHQKIAEEagGKDVGLDYLESFL--VGVVDAALAAQNALVAAESLGLGIVYI- 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 447028033 165 GPVLLAQDELRQYLQIaPEKQINMV-ISLGFPKDKPKKLPR 204
Cdd:cd02146  132 GGIRNNPEEVIELLGL-PEYVFPLFgLTVGHPDPTPEVKPR 171
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 8-195 2.89e-09

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 54.67  E-value: 2.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   8 EVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMN---REKIKEIEQmtwdalhklaakaAENGEek 84
Cdd:cd02145    2 RVIRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSaatRKAVHELFQ-------------RANAE-- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  85 AGKLLTrsfGPYATAFS--------EAPVLI-VCLATSYESKF---REKIFDPIAFvpdsvweeegikSSCLAAQNLMLA 152
Cdd:cd02145   67 AAEMYT---GERAAQYRtlklegieEAPLQLaVFCDRARAGGHglgRTTMPEMDLY------------SSVCAVQNLWLA 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 447028033 153 AHAKGLGtcpmTGPV-LLAQDELRQYLQIAPEKQINMVISLGFP 195
Cdd:cd02145  132 ARAEGLG----VGWVsILDPDEVKRLLGIPEHWEPVAYLCIGYP 171
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
8-66 6.64e-05

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 42.65  E-value: 6.64e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447028033   8 EVIHGRRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREKIKEIEQMT 66
Cdd:PRK10765   6 ELILSHRSIRHFTDEPISEAQREAIINAARAASSSSFLQCSSIIRITDKALREALVELT 64
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 14-204 7.73e-05

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 41.86  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  14 RSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNRE-KIKEIEQMtwdalhklaakaAENGEEKagkllTRS 92
Cdd:cd02148   10 RTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEaKERLVPHL------------SEGNREK-----TMA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  93 fgpyatafseAPVlIVCLAtsYESKFREKIfdPIAF--VPDSVW---------EEEGIKSSCLAAQNLMLAAHAKGLGTC 161
Cdd:cd02148   73 ----------APV-TAILA--YDTEFYEHL--PRLFphGDARSWffgsgparaEETAFRNASLQAAYFILAARALGLDCG 137

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 447028033 162 PMTG-------PVLLAQDELRQylqiapekqiNMVISLGFPkDKPKKLPR 204
Cdd:cd02148  138 PMSGfdaagvdAEFFAGTRWKS----------NLVVNLGYG-DPSKLFPR 176
Frm2-like cd02140
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 6-68 7.62e-04

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380317  Cd Length: 192  Bit Score: 39.21  E-value: 7.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447028033   6 FKEVIHGRRSVRKFTDQ-EVSTNDIKEII-DCARYAPSDTNSQTWEFLVIMNREkikeiEQMTWD 68
Cdd:cd02140    1 FLEAAKARRTIYALGKNsPVSDEEIEEIVkEAVKHVPSSFNSQSSRAVILLGDE-----HKKLWD 60
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 11-61 8.78e-04

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 39.20  E-value: 8.78e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 447028033   11 HGRRSVRKFT--DQEVSTNDIKEIIDCARYAPSDTNSQTWEF-LVIMNREKIKE 61
Cdd:pfam14512 139 AKRKPLDELCvvKEDELPEWFKEGMEAARLAPSAMNQQPWRFvLVDDNRIHAFA 192
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 13-214 1.29e-03

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 38.26  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  13 RRSVRKFTDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIM---NREKIKEieqmtwdalhklaaKAAENGEEKagkll 89
Cdd:PRK05365  16 ARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRsaeAKERLRP--------------ALSEGNLAK----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  90 TRSfgpyatafseAPVlIVCLAtsYESKFREKI--FDPIA-----FVPDSVWEEE-GIKSSCLAAQNLMLAAHAKGLGTC 161
Cdd:PRK05365  77 TLA----------APV-TAIVA--YDTEFHEHLpkLFPHAdarswFAGNPALAEEtAFRNSSLQGAYLILAARALGLDAG 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 447028033 162 PMTGPVLLAQDElrqylQIAPEKQI--NMVISLGFPKDKP--KKLPRKEVDEITTFV 214
Cdd:PRK05365 144 PMSGFDAAAVDA-----EFFAGTTWksNFLVNIGYGDPAKlfPRLPRLSFDEACRIL 195
McbC_SagB-like_oxidoreductase cd02142
oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain ...
 146-186 1.30e-03

oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.


Pssm-ID: 380318  Cd Length: 200  Bit Score: 38.55  E-value: 1.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 447028033 146 AQNLMLAAHAKGLGTCPMTGpvlLAQDELRQYLQIAPEKQI 186
Cdd:cd02142  154 AQNLYLAATALGLGLCAIGA---FDDDALRELLGLDEVEEV 191
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 147-213 2.43e-03

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 37.66  E-value: 2.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447028033  147 QNLMLAAHAKGLGTCpmtgPVLLAQDELRQYLQIAPEKQINMVISLGFPKDKPKKLPRKEVDEITTF 213
Cdd:pfam14512  88 EQIVLYATALGLGTC----WVGGTYSKSKVKAKIKKGEKLVIVIAFGYGATKGVRAKRKPLDELCVV 150
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
5-215 2.73e-03

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 37.64  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033   5 DFKEVIHGRRSVRKF-TDQEVSTNDIKEIIDCARYAPSDTNSQTWEFLVIMNREkikeieqmtwdalhklaakaaenGEE 83
Cdd:PRK11053   2 DIVSVAKKRYTTKAFdPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEE-----------------------GKA 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033  84 KAGKLLTRSFGPYATAFSEAP-VLIVCLATSYESKFREKIFD----------PIA----------FV--------PDSVW 134
Cdd:PRK11053  59 RIAKAAAGNYAFNERKILDAShVVVFCAKTDMDDAYLELVLEqedadgrfatEEAkaaqdkgrrfFAdmhrkelkDLQHW 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447028033 135 EEegiKSSCLAAQNLMLAAHAKGLGTCPMTG---PVLLAQDELRqylqiapEKQIN--MVISLGF--PKDKPKKLPRKEV 207
Cdd:PRK11053 139 ME---KQVYLALGNLLLGAAALGIDATPIEGfdaAILDAEFGLR-------EKGLTssVVVPLGYhsEEDFNAKLPKSRL 208


                 ....*...
gi 447028033 208 DEITTFVF 215
Cdd:PRK11053 209 PQETIFTE 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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