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Conserved domains on  [gi|447043245|ref|WP_001120501|]
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MULTISPECIES: phage holin, lambda family [Enterobacteriaceae]

Protein Classification

phage holin, lambda family( domain architecture ID 10019379)

lambda family phage holin may function in the transport of murein hydrolases (endolysins) across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis; similar to Lambdavirus lambda antiholin and Hamiltonella phage lysis protein S

Gene Ontology:  GO:0019835|GO:0016020|GO:0005886
PubMed:  7669346

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
holin_lambda TIGR01594
phage holin, lambda family; This model represents one of a large number of mutally dissimilar ...
 1-107 3.35e-28

phage holin, lambda family; This model represents one of a large number of mutally dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall. This family includes the product of the S gene of phage lambda. [Mobile and extrachromosomal element functions, Prophage functions]


:

Pssm-ID: 273709  Cd Length: 107  Bit Score: 98.64  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447043245    1 MPHNPNTWPDWLELFQSWWRgdTPLGAVIMSIVMAGLRIAYFGGGggWKRKTLEILLCGALTLTFASALEYVGWPKSLSV 80
Cdd:TIGR01594   2 MIKEPDLWAALLSWLQDAWR--SQGQGALLALAIAYLRIRYMGGK--FKRKLIDALMCAAIALVAASALDFLGLPTSLSP 77

                          90       100
                  ....*....|....*....|....*..
gi 447043245   81 AIGGGVGLIGVDAIRGAAMRVIGNKFG 107
Cdd:TIGR01594  78 FLGGMIGFVGVDKIREFAKRFINKKAG 104
 
Name Accession Description Interval E-value
holin_lambda TIGR01594
phage holin, lambda family; This model represents one of a large number of mutally dissimilar ...
 1-107 3.35e-28

phage holin, lambda family; This model represents one of a large number of mutally dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall. This family includes the product of the S gene of phage lambda. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 273709  Cd Length: 107  Bit Score: 98.64  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447043245    1 MPHNPNTWPDWLELFQSWWRgdTPLGAVIMSIVMAGLRIAYFGGGggWKRKTLEILLCGALTLTFASALEYVGWPKSLSV 80
Cdd:TIGR01594   2 MIKEPDLWAALLSWLQDAWR--SQGQGALLALAIAYLRIRYMGGK--FKRKLIDALMCAAIALVAASALDFLGLPTSLSP 77

                          90       100
                  ....*....|....*....|....*..
gi 447043245   81 AIGGGVGLIGVDAIRGAAMRVIGNKFG 107
Cdd:TIGR01594  78 FLGGMIGFVGVDKIREFAKRFINKKAG 104
Phage_holin_3_1 pfam05106
Phage holin family (Lysis protein S); This family represents one of a large number of mutually ...
 4-105 3.45e-20

Phage holin family (Lysis protein S); This family represents one of a large number of mutually dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall. This family includes the product of the S gene of phage lambda.


Pssm-ID: 428307  Cd Length: 99  Bit Score: 78.03  E-value: 3.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447043245    4 NPNTWPDWLELFQSWWRgdtPLGAVIMSIVMAGLRIAYfgGGGGWKRKTLEILLCGALTLTFASALEYVGWPKSLSVAIG 83
Cdd:pfam05106   3 DPDLWAALLAWLKSYWP---QISGAVLAAVIALLRGIY--DGKSWRKRLLEALLCGALTLAIVSLLEYLGLPASLSVFIG 77

                          90       100
                  ....*....|....*....|..
gi 447043245   84 GGVGLIGVDAIRGAAMRVIGNK 105
Cdd:pfam05106  78 GAIGFLGVDKIRELAKRFINKR 99
 
Name Accession Description Interval E-value
holin_lambda TIGR01594
phage holin, lambda family; This model represents one of a large number of mutally dissimilar ...
 1-107 3.35e-28

phage holin, lambda family; This model represents one of a large number of mutally dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall. This family includes the product of the S gene of phage lambda. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 273709  Cd Length: 107  Bit Score: 98.64  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447043245    1 MPHNPNTWPDWLELFQSWWRgdTPLGAVIMSIVMAGLRIAYFGGGggWKRKTLEILLCGALTLTFASALEYVGWPKSLSV 80
Cdd:TIGR01594   2 MIKEPDLWAALLSWLQDAWR--SQGQGALLALAIAYLRIRYMGGK--FKRKLIDALMCAAIALVAASALDFLGLPTSLSP 77

                          90       100
                  ....*....|....*....|....*..
gi 447043245   81 AIGGGVGLIGVDAIRGAAMRVIGNKFG 107
Cdd:TIGR01594  78 FLGGMIGFVGVDKIREFAKRFINKKAG 104
Phage_holin_3_1 pfam05106
Phage holin family (Lysis protein S); This family represents one of a large number of mutually ...
 4-105 3.45e-20

Phage holin family (Lysis protein S); This family represents one of a large number of mutually dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall. This family includes the product of the S gene of phage lambda.


Pssm-ID: 428307  Cd Length: 99  Bit Score: 78.03  E-value: 3.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447043245    4 NPNTWPDWLELFQSWWRgdtPLGAVIMSIVMAGLRIAYfgGGGGWKRKTLEILLCGALTLTFASALEYVGWPKSLSVAIG 83
Cdd:pfam05106   3 DPDLWAALLAWLKSYWP---QISGAVLAAVIALLRGIY--DGKSWRKRLLEALLCGALTLAIVSLLEYLGLPASLSVFIG 77

                          90       100
                  ....*....|....*....|..
gi 447043245   84 GGVGLIGVDAIRGAAMRVIGNK 105
Cdd:pfam05106  78 GAIGFLGVDKIRELAKRFINKR 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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