|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
5-368 |
1.54e-62 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 204.71 E-value: 1.54e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 5 IYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSL 84
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 85 GAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVS 164
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 165 VLVLVSGIMIQWLLPSSSNKEQLNW---KNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLL 241
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLgllSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 242 ALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTASNGT 321
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 447061980 322 M-INTVHSSFITLGIVIGSSLGGLGISKGyGFVSPLWIGACLAILGVI 368
Cdd:cd17324 321 GlASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALL 367
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
5-379 |
1.09e-41 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 150.43 E-value: 1.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 5 IYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSL 84
Cdd:PRK03545 11 VVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 85 GAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVS 164
Cdd:PRK03545 91 SALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 165 VLVLVSGIMIQWLLPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALY 244
Cdd:PRK03545 171 GGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLLLLF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 245 GSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTASNGT-MI 323
Cdd:PRK03545 251 GGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKLAPDATdVA 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447061980 324 NTVHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLFPYLHKGKA 379
Cdd:PRK03545 331 MALFSGIFNIGIGAGALLGNQ-VSLHLGLSSIGYVGAALALAALVWSILIFRRFPV 385
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
1-373 |
2.92e-40 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 146.39 E-value: 2.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 1 MPSIIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLI 80
Cdd:PRK10091 1 MKKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 81 GQSLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISF 160
Cdd:PRK10091 81 GNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 161 GAVSVLVLVSGIMIQWLLPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYL 240
Cdd:PRK10091 161 LLIAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 241 LALYGSATVVGNIVIGKFADKYT-MKI-LVSGLIILIVALSLFALGaENKYIAVIsTIFIGLTGV-ALNPAMVARVMKTA 317
Cdd:PRK10091 241 MMLVGLGMVLGNLLSGRLSGRYSpLRIaAVTDFIIVLALLMLFFFG-GMKTASLI-FAFICCAGLfALSAPLQILLLQNA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447061980 318 SNGTMINT--VHSSFiTLGIVIGSSLGGLGISKGYGFVSPLWIGACLAILGVISLFPY 373
Cdd:PRK10091 319 KGGELLGAagGQIAF-NLGSAIGAYCGGMMLTLGLAYNYVALPAALLSFAAMSSLLLY 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-317 |
6.03e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 123.16 E-value: 6.03e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 4 IIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQS 83
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 84 LGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAV 163
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 164 SVLVLVSGIMIQWLLPSSSNKEQLNWKNELLR-FKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLA 242
Cdd:COG2814 171 AVLALLALLLLLRLLPESRPAARARLRGSLRElLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447061980 243 LYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTA 317
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-371 |
9.53e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.11 E-value: 9.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAI 87
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 88 AWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLV 167
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 168 LVSGIMIQWLLPSSSNKEQLNWKNELLRFKNIHLW------AAYVTSMFIIGGTFAAFSYFTPIF-TNVTGFSSASIPYL 240
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLlrdrrlLALFLAIFVLAFAFGALEPFLPLYaAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 241 LALYGSATVVGNIVIGKFADKYTMK-ILVSGLIILIVALSLFALgAENKYIAVISTIFIGLTGVALNPAMVARVMKTASN 319
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKpLILIGLLLSAVALLLLPL-ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447061980 320 GTMINT--VHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17325 320 EGRGTAmgLFNTAFSLGMVLGPLLGGF-LYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
4-379 |
5.13e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.18 E-value: 5.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 4 IIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQS 83
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 84 LGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAV 163
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 164 SVLVLVSGIMIQWLL----PSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPY 239
Cdd:COG2223 166 GILLLVVAVLAWLFLrdppAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 240 LLALYGSATVVGNIVIGKFADKY-TMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLT---GVALNPAMVARVMK 315
Cdd:COG2223 246 LAALFALLGALGRPLGGWLSDRIgGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAlggGNGAVFALVPDIFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447061980 316 TASNGTMINTVHSSFITLGIVIGSSLGGLGISKGyGFVSPLWIGACLAILGVISLFPYLHKGKA 379
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-371 |
1.14e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.46 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 4 IIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQS 83
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 84 LGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAV 163
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 164 SVLVLVSGImiqwllpsssnkeqlnwknellrfknIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLAL 243
Cdd:COG2271 171 GLPGLLLAL--------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 244 YGSATVVGNIVIGKFADKY--TMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTASNGT 321
Cdd:COG2271 225 PFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447061980 322 --MINTVHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:COG2271 305 rgTASGLVNTFGFLGGALGPLLVGY-LLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
5-371 |
1.45e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 83.00 E-value: 1.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 5 IYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSL 84
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 85 GAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGlPITTVVSQYFGWRISFGAVS 164
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 165 VLVLVSGIMIQWLLPSSSNKEQLNWKNELLRFKNIH----LWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYL 240
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALrgrgLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 241 LALYGSATVVGNIVIGKFADKYTM--KILVSGLIILIVALSLFALgAENKYIAVISTIFIGLTGVALNPAMVARVMKTAS 318
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKKRFGarRILVIGLLLYALSLLLLGF-VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 447061980 319 NGT--MINTVHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17474 319 EEErgTASSLYNFVRFLGQAVGPLLFGL-LLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-339 |
4.14e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 81.70 E-value: 4.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMM-NELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGA 86
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 87 IAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVL 166
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 167 VLVSGIMIQWLLPSSSNKEQLNWKNE------LLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYL 240
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEArlslivAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 241 LALYGSATVVGNIVIGKFADKY---TMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTA 317
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLgrrRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 447061980 318 SNGTM--INTVHSSFITLGIVIGS 339
Cdd:pfam07690 321 PKEERgtASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-371 |
6.37e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.24 E-value: 6.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAI 87
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 88 AWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQY--FGWRISFGAVSV 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 166 LVLVSGIMIQWLLPSSSNKEQLNWKNE---------LLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSAS 236
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEAssksvlkllKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 237 IPYLLALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALG-AENKYIAVISTIFIGLTGVALNPAMVARVMK 315
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLlAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447061980 316 TAS--NGTMINTVHSSFITLGIVIGSSLGGLGISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd06174 321 LFPpeIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
3-365 |
4.74e-14 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 73.03 E-value: 4.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 3 SIIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQ 82
Cdd:PRK10213 20 SAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSC 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 83 SLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGA 162
Cdd:PRK10213 100 LLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 163 VSVLVLVSGIMIQWLLPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLA 242
Cdd:PRK10213 180 AAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 243 LYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKT-ASNGT 321
Cdd:PRK10213 260 SFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFALVPVGWSTWITRSlADQAE 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 447061980 322 MINTVHSSFITLGIVIGSSLGGLGISKgYGFVSPLWIGACLAIL 365
Cdd:PRK10213 340 KAGSIQVAVIQLANTCGAAIGGYALDN-IGLTSPLMLSGTLMLL 382
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-371 |
1.37e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 71.06 E-value: 1.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 33 FQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSFGVA 112
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 113 ISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLVLVSGIMIQWLLPsssnkeqlnwkne 192
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 193 llrfkniHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTM----KILV 268
Cdd:cd17319 180 -------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarrLVII 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 269 SGLIILIVALSLFALgAENKYIAVistIFIGLTGVALN------PAMVARVMKTASNGTMINTVHSSFiTLGIVIGSSLG 342
Cdd:cd17319 253 IGLLLAAVGLLLAYL-TTSPVVAV---ILLSLAGFGIGaaspvfWSLPADLLPGEAAATAGGLINSGG-NLGGFVAPLLI 327
|
330 340
....*....|....*....|....*....
gi 447061980 343 GLGISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17319 328 GYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
41-181 |
2.11e-13 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 66.90 E-value: 2.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 41 GYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLV 120
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447061980 121 HSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLVLVSGIMIQWLLPSS 181
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-371 |
3.44e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.29 E-value: 3.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 7 LLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGA 86
Cdd:COG2807 22 AIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 87 IAWNYDIMMISRIITGIASASSFgVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVL 166
Cdd:COG2807 102 LAPSVALLLAGTALIGAGIAVGN-VLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 167 VLVSGIMIQWLLPSSSNKEQLNWKNELLR--FKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNvTGFSSASIPYLLALY 244
Cdd:COG2807 181 ALLALLLWLPLLRRRPAAAAAAPAAASLRslWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 245 GSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNP---AMVARVMKTASNGT 321
Cdd:COG2807 260 QLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPlalTLIGLRARTPAEAA 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 447061980 322 MINTVHSSFITLGIVIGSSLGGLGISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:COG2807 340 ALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
8-293 |
8.41e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.14 E-value: 8.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAI 87
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 88 AWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFgAVSVLV 167
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF-YINLPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 168 LVSGIMIQWLLPsssnkeqlnwkneLLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSA 247
Cdd:cd17503 160 GILALLLAPLLD-------------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLA 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 447061980 248 TVVGNIVIGKFADKYTMKILV-SGLIILIVALSLFALGAENKYIAVI 293
Cdd:cd17503 227 SAILSPLVGRLLDKFGPRLLLlAGLLLLALGTLLLAFLTPDTSLWLI 273
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
33-371 |
5.90e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.09 E-value: 5.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 33 FQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSFGVA 112
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 113 ISFSATLVHSDSRGKAASIV----LAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLVLVSGIMIQWllpsssnkeqln 188
Cdd:cd17316 111 STYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRR------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 189 wknellrfknihLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMK-IL 267
Cdd:cd17316 179 ------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKkTL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 268 VSGLIILIVALSLFALGAENKYIAVISTIFI----GLTGVALNPAMVARVMKTASNGTMINTVHsSFITLGIVIGSSLGG 343
Cdd:cd17316 247 VIGLILSGILALPLFYLLSGSPTLLLLLLFIlsffVGGVWGALYAYLAELFPTEVRATGVGLSY-NLGRLGGGGAPPLIA 325
|
330 340
....*....|....*....|....*...
gi 447061980 344 LGISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17316 326 LLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
7-371 |
1.49e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 65.29 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 7 LLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGA 86
Cdd:cd17320 3 LLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 87 IAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVL 166
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 167 VLVSGIMIQWLLPSS--SNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAA-FSYFTP---IFTNVTGFSSASIPYL 240
Cdd:cd17320 163 GLLLLLLVLLFLPETlpEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGlFAYLAAapfIYIEQLGLSPAQFGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 241 LALYGSATVVGNIVIGKFADKYTM-KILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTAS- 318
Cdd:cd17320 243 FALNAIALILGSLLNGRLVRRFGPrRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALe 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 447061980 319 -NGTMINTVHSSFITLGIVIGSSLGGLGISKGYGFVSPLWIG-ACLAILGVISLF 371
Cdd:cd17320 323 pFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLiLVLGLLALLLLI 377
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
68-373 |
1.85e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 64.93 E-value: 1.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 68 KQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSfgVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPIT 147
Cdd:cd17472 62 KPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADLTREENRTKAMALIGASIGIAFAISMVLG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 148 TVVSQYFGWRISFGAVSVLVLVSGIMIQWLLPSSSNKEQLN---WKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTP 224
Cdd:cd17472 140 PLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISekeKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 225 IFTNVTGfssaSIPYLLALYGSATVVGNIVIG---KFADKYTM--KILVSGLIILIVALSLFALGAENKYIAVISTI--F 297
Cdd:cd17472 220 LLTQLGG----GKGQLWKVYLPAILIGFILMVpfvIYAEKKGKmkQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIifF 295
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447061980 298 IGLTGV-ALNPAMVARVMKTASNGTmINTVHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLFPY 373
Cdd:cd17472 296 IGFNLLeALLPSLVSKIAPKEYRGT-AMGIYNTSQFLGSFLGGALGGL-LWGLLGYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
36-368 |
2.53e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.54 E-value: 2.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 36 SVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSFGVAISF 115
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 116 SATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLVLVSGIMIQ--WLLPSSSNKEQLNWKNEL 193
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFlvKDPPPVAAEEAEAGTRAF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 194 LRFKNIHLWAAYVtSMFIIGGTFAAFSYFTPIFTNVTGFSSASIpyLLALYGSATVVGNIVIGKFADKYTMKI-LVSGLI 272
Cdd:cd17489 189 RRLVEKKVLPPAL-ILFLASIAYGAISTFLPLYAAERGISNAGL--FFTVYAIALLLSRPFSGKLSDRKGPKTvIIPGLL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 273 ILIVALSLFALgAENKYIAVISTIFIGLTGVALNPAMVARVMKTA--SNGTMINTVHSSFITLGIVIGSSLGGLgISKGY 350
Cdd:cd17489 266 LLALGLLLLSF-AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVppHRRGAANGTFFIFFDLGIGLGGLLLGL-VAELF 343
|
330
....*....|....*...
gi 447061980 351 GFVSPLWIGACLAILGVI 368
Cdd:cd17489 344 GYRAMFLLAAVVVLLALV 361
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-371 |
1.98e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.36 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMMNELAVAFQV---SVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSL 84
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKlgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 85 GAIAWNYDIMMISRIITGIASASsFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVS 164
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 165 VLVLVSGIMIQWLLPSSSNkeqlnwknellrfknihLWAAYVTSMFIIGGTFAAFSYFTPiftNVTGFSSASIPYLLALY 244
Cdd:cd17330 160 ALALLNLVLVLFFLPPLRR-----------------LLLVYFLIALAFAGLESVFSLFLK---DRFGFSPSQIGLLLALV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 245 GSATVVGNIVIGKFADKY--TMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNP--AMVARVMKTASNG 320
Cdd:cd17330 220 GIAGILAQLLLIPRLAKRlgERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPAlsALLSKSVPSKEQG 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 447061980 321 TMiNTVHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17330 300 KA-QGIIQSLQSLARIIGPLLAGP-LYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
35-367 |
2.25e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 58.34 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 35 VSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSFGVAIS 114
Cdd:cd17477 28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSES 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 115 FSATLVHSDSRGKAASIVLAGLMFATVLGlPITTVVSQYFGWRIsFGAVSVLVLVSGIMIQWLLPSSSNKEQLNWKNELL 194
Cdd:cd17477 108 WLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGALP-FLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 195 RFKNIhlwAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYT--MKILVSGLI 272
Cdd:cd17477 186 LLRIA---PLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDrrRVLLGCALL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 273 ILIVALSLFALGAENKYIAVISTIFiGLTGVALNPAMVARVMKTASNGTMI--NTVHSSFITLGIVIGSSLGGLGISKGY 350
Cdd:cd17477 263 GALAALLLPLVPGLPLALLVLLFLW-GGAAGPLYTLALALAGDRLPGDELVaaNAALLLLYGLGSVIGPLLAGALMDAFG 341
|
330
....*....|....*..
gi 447061980 351 GFVSPLWIGACLAILGV 367
Cdd:cd17477 342 PHGLFLFLAAVALLFLL 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
71-344 |
3.14e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 3.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 71 LLFLMFVFLIGQSLGAIAWnydiMMISRIITGIASASSFGVAISFSATLV-HSDSRGKAASIVLAGLMFATVLGLPITTV 149
Cdd:COG2211 94 SFVLLFTAPDLSPTGKLIY----ALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPP 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 150 VSQYF------GWRISFGAVSVLVLVSGIMIQWLLP--SSSNKEQLNWKNELLR-FKNIHLWAAYVTSMFIIGGTFAAFS 220
Cdd:COG2211 170 LVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKerPVPEEEKVSLKESLKAlLKNRPFLLLLLAYLLFFLALALVAA 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 221 YFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMK--ILVSGLIILIVALSLFALGAENKYIAVISTIFI 298
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKkaFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALA 329
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 447061980 299 GLTGVALNPAMVARVMKTASNGTMINTVHS-----SFITLGIVIGSSLGGL 344
Cdd:COG2211 330 GIGLGAILVLPWAMLADVVDYDEWKTGRRReglyfGIFTFAIKLGQALAGA 380
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-284 |
3.88e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.13 E-value: 3.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 4 IIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQS 83
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 84 LGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAV 163
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 164 SVLVLVSGIMIQWLLPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLAL 243
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 447061980 244 YGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALG 284
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
8-347 |
4.75e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.57 E-value: 4.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAI 87
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 88 AWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFG---AVS 164
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLinvPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 165 VLVLVSGIMIqwllpsssnkeqlnwknellrfknihlWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALY 244
Cdd:cd17321 161 LVALLLARTF---------------------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 245 GSATVVGNIVIGKFADKYTMK-ILVSGLIILIVALSLFA-LGAENKYIAVISTIFI-----GLTGVALNPAMVARVMK-- 315
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRlVLVAGLLLTAVGLLLLAlLGADSSVWLLLPGLVLlglglGLFATPLTNAALSSVPKek 293
|
330 340 350
....*....|....*....|....*....|..
gi 447061980 316 TASNGTMINTVHSSFITLGIVIGSSLGGLGIS 347
Cdd:cd17321 294 AGAASGILNTARQLGGALGVALLGALLTAGLS 325
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
4-325 |
5.10e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.37 E-value: 5.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 4 IIYLLALAIFCMTTSEFMVAG-MMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQ 82
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGfAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 83 SLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISF-- 160
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFyv 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 161 -GAVSVLVLVsgIMIQWL----------------------------LPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFI 211
Cdd:TIGR00895 177 gGIAPLLLLL--LLMRFLpesidflvskrpetvrrivnaiapqmqaEAQSALPEQKSTQGTKRSVFKALFQGKTARITVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 212 IGGTFAA--FSYF-----TPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALG 284
Cdd:TIGR00895 255 LWLLYFMllVGVYfltnwLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGST 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 447061980 285 AENKYIAVISTIFIGLT---GVALNPAMVARVMKTASNGTMINT 325
Cdd:TIGR00895 335 LFSPTLLLLLGAIAGFFvngGQSGLYALMALFYPTAIRATGVGW 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-371 |
5.58e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.17 E-value: 5.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 21 MVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRII 100
Cdd:COG0738 26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 101 TGIAsASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQY---FGWRISFGAVSVLVLVSGIMIQWL 177
Cdd:COG0738 106 LGLG-LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 178 ----LPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNI 253
Cdd:COG0738 185 klpeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 254 VIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTA-SNGTMINTVHSSFIT 332
Cdd:COG0738 265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLgKRTAAAVSAVLIMGI 344
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 447061980 333 LGIVIGSSLGGLgISKGYGFVSPLWI-GACLAILGVISLF 371
Cdd:COG0738 345 VGGAIGPPLIGF-LADAFGLRAAFLVpLVCYLLILLLALA 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
8-369 |
1.99e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 55.66 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAI 87
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 88 AWNYDIMMISRIITGIASAsSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLV 167
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 168 LVSGIMIQWLLPSssnkeqlnwknellRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVT----GFSSASIPYLLAL 243
Cdd:cd17504 160 VLLAALVPLIDLR--------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 244 YGSATVVGNIVIGKFADKYTMK-ILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTASNGTM 322
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPRrVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRT 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447061980 323 --INTVHSSFITLGIVIGSSLGGL------------GISKGYGFVSPLWIGACLAILGVIS 369
Cdd:cd17504 306 giATGMNTVLRTIGSAIGPAIAGAilttytvsitsgGVPTEGAYVLAFLIGAALALAALLL 366
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
8-311 |
2.02e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 55.26 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 8 LALAIFCMTTSEFMVAGMMNELAVAFQvSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAI 87
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 88 AWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGavsvLV 167
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY----IN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 168 LVSGIMIQWLLPSSsnkeqlnwknellrfknihlWAAYVTsMFIIGGTFAAFSYFTPI-FTNVTGFSSASIPYLLALYGS 246
Cdd:cd17502 156 LPIGGLALALLRTI--------------------LLSSIF-GFLFGGALFGLIYYLPLyFQLVLGDSATKSGVRLLPLII 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447061980 247 ATVVGNIVIGKFADK--YTMKILVSGLIILIVALSLFALGAENKYIAVIStIFIGLTGVALNPAMVA 311
Cdd:cd17502 215 GLVIGSIISGALISKtgRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLI-GYLILLGLGLGIGFQQ 280
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
29-372 |
9.01e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 9.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 29 LAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYD-----IMMISRIITGI 103
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslslwLLLVLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 104 ASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLVLVSGIMIQWL------ 177
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIrrpppa 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 178 -LPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVT-GFSSASIPYLLALYGSATVVGNIVI 255
Cdd:cd06173 185 aPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 256 GKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVARVMKTASNGTM--INTVHSSFITL 333
Cdd:cd06173 265 GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgrVFSVYNALNSG 344
|
330 340 350
....*....|....*....|....*....|....*....
gi 447061980 334 GIVIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLFP 372
Cdd:cd06173 345 AMPLGALLAGL-LADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
53-287 |
1.13e-07 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 53.39 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 53 IGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIV 132
Cdd:PRK12307 68 FGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 133 LAGLMFATVLGLPITTVVSQYFGWRISF--GAVSVLVLV--------SGIMIQWLLPSSSNKEQLNWKNELLRFKNIHLW 202
Cdd:PRK12307 148 VSGFGIGNIIAAYFMPSFAEAYGWRAAFfvGLLPVLLVIyirarapeSKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNR 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 203 AAYVTSMFIIGGTFAAFSYFTPIFTNV------TGFSSASIPYLLALYGSATVVGNIVIGKFADKYTM-KILVSGLII-L 274
Cdd:PRK12307 228 AQFPLTLCVFIVLFSIFGANWPIFGLLptylagEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLkKTFSIGLLMsF 307
|
250
....*....|...
gi 447061980 275 IVALSLFALGAEN 287
Cdd:PRK12307 308 LFIFPLFRIPQDN 320
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-371 |
1.26e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.97 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 29 LAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASS 108
Cdd:cd17365 25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 109 FGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISF--GAVSVLVLVsgimiqwllpsssnkeq 186
Cdd:cd17365 105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFllGGVPPLILL----------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 187 lnwkneLLRFKNIHLWAAYVTSMFIIGGTfaafSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMKI 266
Cdd:cd17365 168 ------PLLRGTLLLWVTFFMGLLLVYLL----NSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 267 lVSGLIILIVALSLFALGAENKYIAVISTiFIGLTGVALN------PAMVARVMKTASNGTMINTVHsSFITLGIVIGSS 340
Cdd:cd17365 238 -VLALFFALGAVSLALLGVSPASLVLLYV-LVFLAGACVNgaqvglYALAARFYPTEVRATGVGWAL-GVGRLGAILGPL 314
|
330 340 350
....*....|....*....|....*....|.
gi 447061980 341 LGGLGISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17365 315 LGGLLLAAGLGPESVFLALAIPAALGALAVL 345
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
21-160 |
4.47e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 51.62 E-value: 4.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 21 MVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRII 100
Cdd:PRK03893 38 LITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLV 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 101 TGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISF 160
Cdd:PRK03893 118 IGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALF 177
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
21-371 |
7.96e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 7.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 21 MVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRII 100
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 101 TGIASASsFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLG-LPITTVVSQYFGWRISFGAVSVLVLVSGIMIQWLLP 179
Cdd:cd17478 94 AGIGSAA-FHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGpLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 180 SSSNKEQLN--WKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGK 257
Cdd:cd17478 173 KKPEAKKAAakSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 258 FADKY-TMKILVSGLIILIVALSLFALgaENKYIAVISTIFIGLTGVALNPAMVARVMKTASNGtmINTVHSSFITLGIV 336
Cdd:cd17478 253 LSDRFgRRRVIIASLLLAAPFLLLFLL--TPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGN--VGLASGLMMGLSFG 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 447061980 337 IGSSLGGL--GISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17478 329 LGGIGAPVlgALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
24-372 |
1.54e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.58 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 24 GMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISR-IITG 102
Cdd:cd17355 24 VFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 103 IASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLVLVSGIMIQWLLPSSS 182
Cdd:cd17355 104 GGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 183 NKEQLNWKNE---------LLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNI 253
Cdd:cd17355 184 ADLALRAYDDaspaspgstLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 254 VIGKFADKYTMKILVSGLIIL-IVALSLFALGAENKYIAVISTIFIGLTG---VALNPAMVARVMKTASNGTMINTVHSS 329
Cdd:cd17355 264 LSGWLGDRYSPRRLLAASYALrALGLALLLLLPFPPLALLLFAALFGLGWgatVPLTAALAARYFGARSYGTLFGLVFAP 343
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 447061980 330 FiTLGIVIGSSLGGLGISKGYGFVSPLWIGACLAILGVISLFP 372
Cdd:cd17355 344 H-QLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
7-318 |
7.05e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 7.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 7 LLALAIFCMTTSEFMVAGMMNELAVAFQ-VSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLG 85
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 86 AIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGK-----AASIVLAGLMFATVLGLPITtvvsqyFGWRISF 160
Cdd:cd17473 83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKmlglqSAAMSLGGVVFLLLGGALAE------IGWRAPF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 161 gAVSVLVLVSGIMIQWLLPSSSNKEQ---LNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASI 237
Cdd:cd17473 157 -LVYLLALPVLILVLLFLPEPARKSKsaaSPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 238 PYLLALYGSATVVGNIVIGKFADKYT-MKILVSGLIILIVALSLFALgAENKYIAVISTIFIGLTGVALNPAMVARVMKT 316
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGkRRLLAIGFALMALGFLLLAL-ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314
|
..
gi 447061980 317 AS 318
Cdd:cd17473 315 VP 316
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-184 |
1.19e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 5 IYLLALAIFCMTTSEFMVAGMMNELAV-AFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQS 83
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIGDWLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 84 LGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSrGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAV 163
Cdd:COG0738 292 LALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVP 370
|
170 180
....*....|....*....|.
gi 447061980 164 SVLVLVSGIMIQWLLPSSSNK 184
Cdd:COG0738 371 LVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
201-368 |
1.25e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 201 LWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMK-ILVSGLIILIVALS 279
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKpVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 280 LFALgAENKYIAVISTIFIGLTGVALNPAMVARV--MKTASNGTMINTVHSSFITLGIVIGSSLGGLGIskGYGFVSPLW 357
Cdd:cd17329 81 LLGF-AHSPWLFAIALVLTGFGGGLFEPASEAMIadVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL--LYSFRLLFL 157
|
170
....*....|.
gi 447061980 358 IGACLAILGVI 368
Cdd:cd17329 158 AAAVLFLLAAL 168
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-179 |
6.72e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.48 E-value: 6.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 5 IYLLALAIFCMTTSEFMVAGMMNELAV-AFQVSVSSIGYLISAYAGAMVIGGPILTAILLRM--RSKQALLFLMFVFLIG 81
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 82 QSLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFG 161
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170
....*....|....*...
gi 447061980 162 AVSVLVLVSGIMIQWLLP 179
Cdd:COG2271 342 LLAALALLAALLALLLLR 359
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-172 |
9.10e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 9.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 2 PSIIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIG 81
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 82 QSLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFG 161
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|.
gi 447061980 162 AVSVLVLVSGI 172
Cdd:cd06173 368 LAGALLLLAAL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
5-370 |
1.75e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 5 IYLLALAIFCMTTSEFMVAGMMNELAVAFQ-VSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQS 83
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLgLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 84 LGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYfGWRISFGAV 163
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 164 SVLVLVSGIMIQWLLP----SSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIF-TNVTGFSSASIP 238
Cdd:cd17329 160 AVLFLLAALVLLFLLPetrpKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYvVEILGLGESLLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 239 YLLALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAM---VARVMK 315
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVqtlVAALAP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 447061980 316 TASNGTMiNTVHSSFITLGIVIGSSLGGLGISkGYGFVSPLWIGACLAILGVISL 370
Cdd:cd17329 320 PDKRGSY-MGFYALAWGLGRAIGPLVGGLLLD-LLGPGLPWLILAALGLIAAALL 372
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
86-180 |
1.85e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.93 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 86 AIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSV 165
Cdd:cd17380 84 LAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
90
....*....|....*
gi 447061980 166 LVLVSGIMIQWLLPS 180
Cdd:cd17380 164 LGLLWALVWLIYLPP 178
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
70-371 |
2.06e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.98 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 70 ALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASSFGVAISFsatlvHSDSRGKAASIVLAGLMFATVLGLPITTV 149
Cdd:cd17353 75 GILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKW-----FPDKRGLATGIVIAGFGLGSLIFSPLIAY 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 150 VSQYFGWRISFGAVSVLVLVSGIMIQWLL--------PSSSNKEQLNWKNELLRF------KNIHLWAAYVTSMFIIGGT 215
Cdd:cd17353 150 LINTVGVPTTFLILGIIFLIIIVIGAFLIrdppkgwvPPGVDPLANNAENSPRDYtpremlRTPTFWLLWLMFFLNATAG 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 216 FAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYT-MKILVSGLIILIVALSLFALGAENKYIAVIS 294
Cdd:cd17353 230 LMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGrKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLG 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 295 TIFIGLT---GVALNPAMVARVMKTASNGTMINTVHSSFITLGIvIGSSLGGLgISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17353 310 VALIGFCyggGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGL-IGPIIAAY-VLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
72-371 |
3.25e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.51 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 72 LFLMFV--FLIG-----QSLGAIAWNydIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGL 144
Cdd:cd17369 81 LLLMGIatFLIGllptyAQIGILAPI--LLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLAT 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 145 PITTVVSQYF--------GWRISFGAVSVLVLVsGIMIQWLLPSS--------SNKEQLNWKNELLRfkniHLWAAYVTS 208
Cdd:cd17369 159 GVFLLLSALLsdeaflswGWRIPFLLSAVLVAV-GLYIRLRLEETpvfrrakeAGQVVRAPLVEVLR----RHWRALLLA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 209 MFIIGGTFAAFsYFTPIF-----TNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMK--ILVSGLIILIVALSLF 281
Cdd:cd17369 234 IGLRLAENVLF-YLFTTFalsyaTQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRpvYLAGALLAALFAFPFF 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 282 -ALGAENKYIAVISTIFIGLTGVAL----NPAMVARVMKTAsngtmintVHSSFITLGIVIGSSLGG-------LGISKG 349
Cdd:cd17369 313 wLLDTGSTWLIVLAAVVVLGVLHGMmygpQAAFLAELFPTR--------VRYTGASLGYQLGAILGGgfapliaTALVAA 384
|
330 340
....*....|....*....|..
gi 447061980 350 YGfvSPLWIGACLAILGVISLF 371
Cdd:cd17369 385 TG--SWWPVALYLAALAVISLV 404
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
203-375 |
3.35e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 203 AAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFA 282
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 283 LGAENKYIAVISTIFIGLTGVALNPAMVARVMKTASNG--TMINTVHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGA 360
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPErrGRALGLLGAGLGLGPALGPLLGGL-LADLFGWRWVFLVNA 171
|
170
....*....|....*
gi 447061980 361 CLAILGVISLFPYLH 375
Cdd:COG2814 172 VLALLALLLLLRLLP 186
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
26-372 |
4.41e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 41.88 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 26 MNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIAS 105
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 106 ASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGAVSVLVLVSGIMIQWllpsssnke 185
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFF--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 186 qlnwkneLLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKY--- 262
Cdd:cd17312 177 -------FLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgg 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 263 -TMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTgVALNPAMVARVMKTASNGTMINTVHSSFITLGIVIGSSL 341
Cdd:cd17312 250 rRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFF-VGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASL 328
|
330 340 350
....*....|....*....|....*....|....
gi 447061980 342 GGLG---ISKGYGFVSPLWIGACLAILGVISLFP 372
Cdd:cd17312 329 AGLPlgyIIDHYGWSTVFYFLISAALLSVLLLLS 362
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
34-285 |
4.80e-04 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 41.95 E-value: 4.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 34 QVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWnydimMISRIITGIASASSFGVAI 113
Cdd:PRK03633 42 QVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLGLMVGFWSW-----LAWRFVAGIGCAMIWVVVE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 114 SFSATLVHSDSRGkaasIVLAGLMFATVLGlpitTVVSQYFGWRISFGAVSVLVLVSGIMIQWLLP------SSSNKEQL 187
Cdd:PRK03633 117 SALMCSGTSRNRG----RLLAAYMMVYYLG----TVLGQLLVSKVSTELMSVLPWVTGLVLAAILPllftriLNQQAENH 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 188 N----WKneLLRFKNIHLWaayVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKY- 262
Cdd:PRK03633 189 DstsiWP--MLKLRQARLG---VNGCIISGIVLGSLYGLMPLYLNHQGMSDASIGFWMALLVSAGILGQWPIGRLADRFg 263
|
250 260 270
....*....|....*....|....*....|....
gi 447061980 263 ---TMKILVSGLIILIVAL--------SLFALGA 285
Cdd:PRK03633 264 rllVLRVQVFVVILGSIAMlsqaamapALFILGA 297
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
20-259 |
5.88e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 5.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 20 FMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRI 99
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 100 ITGIASASSFGVAISFSATLVHSDSRGKAASIVLA----GLMFATVLGLPITTVVSQYFGWRISF--GAVSVLVLvsgIM 173
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSgwavGWLLATLLAALLFPLLPPEIAWRVLFllGALPALLV---LF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 174 IQWLLPSSS--NKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVG 251
Cdd:cd17371 173 IRRFVKEPPqwQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLV 252
|
....*...
gi 447061980 252 NIVIGKFA 259
Cdd:cd17371 253 VTILGGFL 260
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
4-371 |
6.73e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.44 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 4 IIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQS 83
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 84 LGAIAWNYDIMMISRIITGIASAssFGVAISFSATLvhSDSRGKAASIVLAGLMFAT--VLGLPITTVVSQYFGWRISFG 161
Cdd:cd17331 81 LLAFASSVPMLFLSRLPSVFMHA--MQAAQMVVTDL--TDPGERAAALGRLGLSYGIgmVVGSFLGGLLTKKFGEQAAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 162 AVSVLVLVSGIMIQWLLP-------------SSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTN 228
Cdd:cd17331 157 VAAVGSLLSIVLVILLIPsntkskrekeakeSASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 229 VTGFSSASIPYLLALYGSATVVGN-IVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNP 307
Cdd:cd17331 237 FFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447061980 308 AMVARVMKTAS---NGTMINTVHSSFITLGIVigSSLGGLGISKGYGFVSPLWIGACLAILGVISLF 371
Cdd:cd17331 317 VITSLLTKAVPpedTGTALGLSHALFSLVRTV--SPTIGGALLQAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-344 |
1.01e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.07 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 19 EFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISR 98
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 99 IITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYF-GWRISFGAVSVLVLVSGIMIQWL 177
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 178 LP-----------SSSNKEQLNWKNELLRFKN---IHLWAAYVTSMFIIGgtfaAFSYFTPIF----TNVTGFSSASIP- 238
Cdd:cd17328 175 VRepprgaaeggvMAKSTATSFLADLKALAKNpsfILSTLGFTAVSFVTG----ALAFWAPTFflraFGVGDLSSADVGl 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 239 YLLALYGSATVVGNIVIGKFADKYTMK-------ILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVA 311
Cdd:cd17328 251 IFGAITCIAGVLGVLLGGILADRLRRKtpradplVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVF 330
|
330 340 350
....*....|....*....|....*....|...
gi 447061980 312 RVMKTASNGTMINTVHSSFITLGIVIGSSLGGL 344
Cdd:cd17328 331 AILLYVVIPTRRSTASAIQILLSHLLGDAGSPY 363
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
34-282 |
1.05e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 34 QVSVSSIGYLISAYAgamviggpiLTAILLRM---------RSKQALLFLMFVFLIGQSLGAIAWNYDIM-MISRIITGI 103
Cdd:cd17490 27 GASLSMIGIILGAYG---------ISQMLLRIplgilsdriGKRKLFIIIGLLFTVLASLIMILFPSPWGlLIARFLSGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 104 ASASSFGVAISFSATLVHSDSrGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFgAVSVLVLVSGIMIQWLL--PSS 181
Cdd:cd17490 98 AAATWVSFTVLYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPF-LLAALAGVLGFILSLFIkeERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 182 SNKEQLNWKNELLR-FKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFAD 260
Cdd:cd17490 176 EKKPVLTELKELLSvLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFY 255
|
250 260
....*....|....*....|..
gi 447061980 261 KYTMKILVSGLIILIVALSLFA 282
Cdd:cd17490 256 KKLGERNTIIIGFLLLGAYCFL 277
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
208-375 |
1.94e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 208 SMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAEN 287
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 288 KYIAVISTIFIGLTGVALNPAMVARVMKTA--SNGTMINTVHSSFITLGIVIGSSLGGLGIS-KGYGFVSPLWIGACLAI 364
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILASsLGFGWRAVFLIAAALAL 163
|
170
....*....|.
gi 447061980 365 LGVISLFPYLH 375
Cdd:cd06174 164 LAAILLLLVVP 174
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
3-196 |
2.25e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 3 SIIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQ 82
Cdd:TIGR01299 167 ALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFA 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 83 SLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISFGA 162
Cdd:TIGR01299 247 FFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQMGS 326
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 447061980 163 V------SVLVLVSGimiqwlLPSSSNKEQLNWKNELLRF 196
Cdd:TIGR01299 327 AyqfhswRVFVIVCA------FPCVFAIGALTFMPESPRF 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
20-311 |
2.44e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 20 FMVAGMMNELAV--------AFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNY 91
Cdd:cd17333 5 FFSNGLTDALLGilgpsleeAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 92 DIMMISRIITGIASasSFGVAISFSATLVHSDSRGKAASIVLAGL--MFATVLGLPITTVVSQYFGWRISFGAVSVLVLV 169
Cdd:cd17333 85 YLFVVLMFLAGLGA--GILDTGANTFVGALFEESSATRLNVLHGFfgLGALIGPLIATSLLTSELSWSWAYLIIGLIYLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 170 sgIMIQWLLPSSSNKEQLNWKNELLR---------FKNIHLWAAYVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYL 240
Cdd:cd17333 163 --LAILILLTLFPELPSARNPQQSVGafsasasrlLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447061980 241 LALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALGAENKYIAVISTIFIGLTGVALNPAMVA 311
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILS 311
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
29-182 |
3.11e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.18 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 29 LAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIASASS 108
Cdd:PRK11551 41 MAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGA 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447061980 109 FGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGWRISF--GAVSVLVLVSGIMiqWLLPSSS 182
Cdd:PRK11551 121 LPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFyvGGVGPLLLVPLLM--RWLPESR 194
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
5-172 |
3.63e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 5 IYLLALAIFCMTTSEFMVAGMMNELAVAFQ-VSVSSIGYLISAYAGAMVIGGpILTAILLRMRSKQALLFLMFVFL-IGQ 82
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGA-LLFGRLKRRLGKRRLLAIGFALMaLGF 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 83 SLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLG-LPITTVVSQYFGWRISFG 161
Cdd:cd17473 278 LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSpLVLGPLVNLTGGLSGAFL 357
|
170
....*....|.
gi 447061980 162 AVSVLVLVSGI 172
Cdd:cd17473 358 ILGVLALVLAI 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-142 |
4.13e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 2 PSIIYLLALAIFCMTTSEFMVAGMMNELAVAFQVSVSSIGYLISAYAGAMVIGGPILTAILLRMRSKQALLFLMFVFLIG 81
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447061980 82 QSLGAIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVL 142
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
26-180 |
4.58e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 38.87 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 26 MNELAVAFQVSVSSIGYLISAYAGAMVIGgpiltaillRMRSKQALLFLMFVFLIGQSLGAIAWNYDIMMISRIITGIAS 105
Cdd:cd17362 36 LSSLQSGLVVSGSLLGALLGSLVAGALID---------RLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGI 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447061980 106 ASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYF-GWRISFGAVSVLVLVSGIMIQWLLPS 180
Cdd:cd17362 107 GLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPALLLGIGMWFLPPS 182
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
205-371 |
4.65e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 205 YVTSMFIIGGTFAAFSYFTPIFTNVTGFSSASIPYLLALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALSLFALG 284
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 285 AENKYIAVISTIFIGLTGVALNPAMVARVMKTASNG--TMINTVHSSFITLGIVIGSSLGGLgISKGYGFVSPLWIGACL 362
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEerGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFLILAIL 160
|
....*....
gi 447061980 363 AILGVISLF 371
Cdd:pfam07690 161 SLLAAVLLL 169
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
93-316 |
8.47e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.04 E-value: 8.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 93 IMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYF--------GWRISFGAVS 164
Cdd:cd17367 103 ILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaawGWRIPFLLGG 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 165 VLVLVSGIMIQWL--LPSSSNKEQLNWKNELLRFKNIHLWAAYVTSMFIIGGTFAAFSYFT---PIF-TNVTGFSSASIP 238
Cdd:cd17367 183 VLAVVVLWLRRGLeeTESFEAIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFYTWTtylQKFlVNTAGFSKGDAT 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447061980 239 YLLALYGSATVVGNIVIGKFADKYTMKILVSGLIILIVALS---LFALGAENKYIAVISTIFIGLT----GVALNPAMVA 311
Cdd:cd17367 263 WITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATvplLSALDHTDSPYTAFALVLVGLVflsgYTSINAVVKA 342
|
....*
gi 447061980 312 RVMKT 316
Cdd:cd17367 343 ELFPT 347
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
86-156 |
8.50e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 37.98 E-value: 8.50e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447061980 86 AIAWNYDIMMISRIITGIASASSFGVAISFSATLVHSDSRGKAASIVLAGLMFATVLGLPITTVVSQYFGW 156
Cdd:cd17318 106 AARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGW 176
|
|
| |
