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Conserved domains on  [gi|447066225|ref|WP_001143481|]
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MULTISPECIES: flagellar hook assembly protein FlgD [Bacillus]

Protein Classification

flagellar hook assembly protein FlgD( domain architecture ID 11482417)

flagellar hook assembly protein FlgD may act as a scaffolding protein required for flagellar hook formation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
flgD PRK06792
flagellar basal body rod modification protein; Validated
 1-190 8.71e-120

flagellar basal body rod modification protein; Validated


:

Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 336.99  E-value: 8.71e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225   1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80
Cdd:PRK06792   1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNNGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFI 160
Cdd:PRK06792  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNDGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFV 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 447066225 161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
Cdd:PRK06792 161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
 
Name Accession Description Interval E-value
flgD PRK06792
flagellar basal body rod modification protein; Validated
 1-190 8.71e-120

flagellar basal body rod modification protein; Validated


Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 336.99  E-value: 8.71e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225   1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80
Cdd:PRK06792   1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNNGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFI 160
Cdd:PRK06792  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNDGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFV 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 447066225 161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
Cdd:PRK06792 161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
26-148 1.98e-19

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 81.97  E-value: 1.98e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  26 SVTGAQSTAQQANGVSASTQKTPGI-MDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQST 104
Cdd:COG1843    2 ATSSSSSVLSSLSTSSTSSSSSSSSsLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLESLASS 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 447066225 105 MYSTALDGGMKFLGKYVRGVSN----NGKQVTGQVETVRLAENNDVQL 148
Cdd:COG1843   82 LTSSQALQASSLIGKEVLVEGNtislDGGSASGGFELPSAADSVTVTI 129
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 30-100 1.35e-18

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 75.74  E-value: 1.35e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447066225   30 AQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDK 100
Cdd:pfam03963   5 NSSSTTSTSSSSSTSAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTLDS 75
 
Name Accession Description Interval E-value
flgD PRK06792
flagellar basal body rod modification protein; Validated
 1-190 8.71e-120

flagellar basal body rod modification protein; Validated


Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 336.99  E-value: 8.71e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225   1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80
Cdd:PRK06792   1 MPTVGLNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNNGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFI 160
Cdd:PRK06792  81 QTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVRGVSNDGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFV 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 447066225 161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
Cdd:PRK06792 161 ERVSDKPITETNPEDEKKDDIEKNEEVKPD 190
flgD PRK11911
flagellar basal body rod modification protein; Provisional
 38-152 2.78e-26

flagellar basal body rod modification protein; Provisional


Pssm-ID: 138812 [Multi-domain]  Cd Length: 140  Bit Score: 97.99  E-value: 2.78e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  38 NGVSASTQKTPGimdKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFL 117
Cdd:PRK11911  16 NAVTSSVSKTLG---KDDFMKLFLTSLQYQDPSSPLDTNEMMSQMAQLSLMEQVANMTTAVDKLSEQAQNSALQSAVNFI 92

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447066225 118 GKYVRGVSNNGKQVTGQVETVRLAENNDVQLIVDN 152
Cdd:PRK11911  93 GKDIKGVSLNGEVISGKVESVQQTTNGVMLKLKDN 127
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
26-148 1.98e-19

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 81.97  E-value: 1.98e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  26 SVTGAQSTAQQANGVSASTQKTPGI-MDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQST 104
Cdd:COG1843    2 ATSSSSSVLSSLSTSSTSSSSSSSSsLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLESLASS 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 447066225 105 MYSTALDGGMKFLGKYVRGVSN----NGKQVTGQVETVRLAENNDVQL 148
Cdd:COG1843   82 LTSSQALQASSLIGKEVLVEGNtislDGGSASGGFELPSAADSVTVTI 129
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 30-100 1.35e-18

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 75.74  E-value: 1.35e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447066225   30 AQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDK 100
Cdd:pfam03963   5 NSSSTTSTSSSSSTSAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTLDS 75
flgD PRK09618
flagellar hook assembly protein FlgD;
25-166 6.01e-16

flagellar hook assembly protein FlgD;


Pssm-ID: 236594 [Multi-domain]  Cd Length: 142  Bit Score: 70.80  E-value: 6.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  25 ASVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQST 104
Cdd:PRK09618   1 MTMTGIDSSLWLANSKKAERRTGNQNLGKDDFLKLLITQLQNQDPTNPMEDKEFIAQMAQFSSLEQMTNMNKSMEKLVSS 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447066225 105 mystaLDGGMKF---LGKYVRGVSNNGKQVTGQVETVRLAENNDVQLIVDNQVVSLRFIERVSDK 166
Cdd:PRK09618  81 -----SDGLTKYselIGKEVEWEGEDGEIVSGTVTSVKQKDGDYPLVLDNGTWIVADNVTSVGLK 140
flgD PRK12812
flagellar basal body rod modification protein; Reviewed
 6-141 6.83e-15

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 139245 [Multi-domain]  Cd Length: 259  Bit Score: 70.67  E-value: 6.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225   6 LNTTSTNHIPLQAGAQTKNASVTGAQSTAQQANGVsastqktpgiMDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQL 85
Cdd:PRK12812   9 LNTTATTSTTTKSASTSGATRTDSSSSTGSNPNSQ----------LDKDAFLKLLLIELQHQDPTDPMDSDKMLTQTSQL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447066225  86 SLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKYVrGVSNNGKQVTGQVETVRLA 141
Cdd:PRK12812  79 AALEMQENTNTTMQKLVEQMQSSMSTSALSALGKMA-TVSDNAVKLTGADELIALK 133
flgD PRK06009
flagellar hook assembly protein FlgD;
26-143 6.54e-13

flagellar hook assembly protein FlgD;


Pssm-ID: 235670 [Multi-domain]  Cd Length: 140  Bit Score: 62.80  E-value: 6.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  26 SVTGAQSTAQQANGVSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKavdKLQSTM 105
Cdd:PRK06009   8 SATSSSTTSSTSTASNSTSAANKASVNYDSFLQLLIAQMKNQDPTDPMDATQYVSQLATFSQVEQSIQTNS---KLDTLL 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447066225 106 YSTALDGGMKFLGKYVrgVSNNGKqVTGQVETVRLAEN 143
Cdd:PRK06009  85 ASSSLTQAEGLIGRTV--TSADGS-ITGVVKSVTVYSD 119
flgD PRK06655
flagellar hook assembly protein FlgD;
24-107 9.42e-09

flagellar hook assembly protein FlgD;


Pssm-ID: 235847 [Multi-domain]  Cd Length: 225  Bit Score: 53.03  E-value: 9.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  24 NASVTGAQSTAQQANGVSASTQKTPGIMD--KDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKL 101
Cdd:PRK06655   1 MSIANTVGSSSTSGLSTTSSSSSSKKGAAdlQDDFLTLLVAQLKNQDPLNPMDNSQMTSQLAQFSTVSGIEKLNTTLGSL 80


                 ....*.
gi 447066225 102 QSTMYS 107
Cdd:PRK06655  81 SSQMTS 86
flgD PRK12634
flagellar basal body rod modification protein; Reviewed
 41-121 1.28e-08

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 183639 [Multi-domain]  Cd Length: 221  Bit Score: 52.62  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  41 SASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTMYSTALDGGMKFLGKY 120
Cdd:PRK12634  17 SSKTAKKEEALGQADFLKLMTEQLQHQDPLKPMENSAFLGQLAQFSTVQGIGDLNTKVSNFSDSMSSDQVLKGAALVGHN 96


                 .
gi 447066225 121 V 121
Cdd:PRK12634  97 V 97
flgD PRK05842
flagellar hook assembly protein FlgD;
25-108 2.14e-06

flagellar hook assembly protein FlgD;


Pssm-ID: 235621 [Multi-domain]  Cd Length: 295  Bit Score: 46.91  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  25 ASVTGAQStAQQAngvSASTQKTPGIMDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQST 104
Cdd:PRK05842   6 AEVTGAKA-AQER---KKEQPTIANGLDKNAFMKLFLEQLKNQDPTAPMETDKIITQTAQLTQVEMQEENKKTMQEVASA 81


                 ....
gi 447066225 105 MYST 108
Cdd:PRK05842  82 MKSN 85
flgD PRK12813
flagellar basal body rod modification protein; Reviewed
 19-153 9.88e-06

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 237214 [Multi-domain]  Cd Length: 223  Bit Score: 44.33  E-value: 9.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447066225  19 GAQTKNASVTGAQSTAQQANGVSAStqktpgimDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAV 98
Cdd:PRK12813   6 GTVTSPGTTTGSSRGSASAASALTS--------DFETFLRMLTTQLQNQDPLNPMDSSDYAAQLATFSGVEQQVKTNDLL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447066225  99 DKLQSTMYSTALDGGMKFLGKYVRGVSN---NGKQVTGQVETVRLAENndVQLIVDNQ 153
Cdd:PRK12813  78 TGLGASLGVMGLSQLAGWIGREARAEAPvwfDGTPVTISPNPAADADK--AELVVRDA 133
flgD PRK09619
flagellar hook assembly protein FlgD;
24-96 1.20e-05

flagellar hook assembly protein FlgD;


Pssm-ID: 181996 [Multi-domain]  Cd Length: 218  Bit Score: 44.00  E-value: 1.20e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447066225  24 NASVTGAQSTAQQANGVSASTQKtpgimdKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTK 96
Cdd:PRK09619   7 RNSANVGNQSPAPEGGLPGAEQL------NNQFMTLLVAQIQNQDPLNPADGTEFVSQLAQLSQVQSTENMAK 73
flgD PRK12633
flagellar basal body rod modification protein; Provisional
 26-98 5.20e-05

flagellar basal body rod modification protein; Provisional


Pssm-ID: 183638 [Multi-domain]  Cd Length: 230  Bit Score: 42.27  E-value: 5.20e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447066225  26 SVTGAQSTAQQANGVSASTQKTPGIMDKddFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAV 98
Cdd:PRK12633   3 TVNETTSQAGLALAQAGSNSAAQGIQDQ--FLTLLVTQLRNQDPLNPMENAELTSQLAQISTVEGINNLKNTM 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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