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Conserved domains on  [gi|447074451|ref|WP_001151707|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator C-terminal ligand-binding domain-containing protein [Acinetobacter]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442337)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 80-176 2.42e-09

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


:

Pssm-ID: 435608  Cd Length: 113  Bit Score: 52.57  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447074451   80 DLGSFQQDITAWVEQYFEEYASEVGQDLLRDVL--YTSNSDSNARKCETLIIQQLDIIQ---NRAKLRNEL--TIPNQVI 152
Cdd:pfam16859   3 DTGSLRGDLRALLRALARALTSPRGGALLRALIaaAQRDPELAAALRERFLEPRRAALRavlERAVARGELrpDADPDLV 82

                          90       100
                  ....*....|....*....|....
gi 447074451  153 IEAVIAPMLFRILFTNHDLSLEYV 176
Cdd:pfam16859  83 LDLLFGPLYYRLLLTGEPLDEAYA 106
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-102 4.37e-05

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 41.81  E-value: 4.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447074451  13 RSERIQTAVHQAVKEL--QKDFEQsqITIPMIAVQAGVTPSTIYRRWGDINQLFSDV---ALNELKPDM-EPKDLGSFQQ 86
Cdd:COG1309    3 RREATRERILDAALELfaEKGYEG--TSVRDIAARAGVSKGTLYRHFGSKEELLLAVlerLLEELLAALeEALAAEDPRE 80

                         90
                 ....*....|....*.
gi 447074451  87 DITAWVEQYFEEYASE 102
Cdd:COG1309   81 RLRALLRAYLEFLAEN 96
 
Name Accession Description Interval E-value
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 80-176 2.42e-09

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 52.57  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447074451   80 DLGSFQQDITAWVEQYFEEYASEVGQDLLRDVL--YTSNSDSNARKCETLIIQQLDIIQ---NRAKLRNEL--TIPNQVI 152
Cdd:pfam16859   3 DTGSLRGDLRALLRALARALTSPRGGALLRALIaaAQRDPELAAALRERFLEPRRAALRavlERAVARGELrpDADPDLV 82

                          90       100
                  ....*....|....*....|....
gi 447074451  153 IEAVIAPMLFRILFTNHDLSLEYV 176
Cdd:pfam16859  83 LDLLFGPLYYRLLLTGEPLDEAYA 106
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-102 4.37e-05

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 41.81  E-value: 4.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447074451  13 RSERIQTAVHQAVKEL--QKDFEQsqITIPMIAVQAGVTPSTIYRRWGDINQLFSDV---ALNELKPDM-EPKDLGSFQQ 86
Cdd:COG1309    3 RREATRERILDAALELfaEKGYEG--TSVRDIAARAGVSKGTLYRHFGSKEELLLAVlerLLEELLAALeEALAAEDPRE 80

                         90
                 ....*....|....*.
gi 447074451  87 DITAWVEQYFEEYASE 102
Cdd:COG1309   81 RLRALLRAYLEFLAEN 96
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
38-67 2.22e-03

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 34.69  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 447074451   38 TIPMIAVQAGVTPSTIYRRWGDINQLFSDV 67
Cdd:pfam00440  18 TVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 80-176 2.42e-09

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 52.57  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447074451   80 DLGSFQQDITAWVEQYFEEYASEVGQDLLRDVL--YTSNSDSNARKCETLIIQQLDIIQ---NRAKLRNEL--TIPNQVI 152
Cdd:pfam16859   3 DTGSLRGDLRALLRALARALTSPRGGALLRALIaaAQRDPELAAALRERFLEPRRAALRavlERAVARGELrpDADPDLV 82

                          90       100
                  ....*....|....*....|....
gi 447074451  153 IEAVIAPMLFRILFTNHDLSLEYV 176
Cdd:pfam16859  83 LDLLFGPLYYRLLLTGEPLDEAYA 106
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-102 4.37e-05

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 41.81  E-value: 4.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447074451  13 RSERIQTAVHQAVKEL--QKDFEQsqITIPMIAVQAGVTPSTIYRRWGDINQLFSDV---ALNELKPDM-EPKDLGSFQQ 86
Cdd:COG1309    3 RREATRERILDAALELfaEKGYEG--TSVRDIAARAGVSKGTLYRHFGSKEELLLAVlerLLEELLAALeEALAAEDPRE 80

                         90
                 ....*....|....*.
gi 447074451  87 DITAWVEQYFEEYASE 102
Cdd:COG1309   81 RLRALLRAYLEFLAEN 96
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
38-67 2.22e-03

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 34.69  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 447074451   38 TIPMIAVQAGVTPSTIYRRWGDINQLFSDV 67
Cdd:pfam00440  18 TVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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