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Conserved domains on  [gi|447088885|ref|WP_001166141|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Vibrio]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007814)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0090729
PubMed:  20143871|20487277|28279904|15718296

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
1-92 3.32e-20

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


:

Pssm-ID: 442885  Cd Length: 96  Bit Score: 77.24  E-value: 3.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447088885  1 MQIKWLKKALINLEHSAEYLQEQ-NPQSARDFVKEVHELTELLKANPAMGRP---GRVFGTRELILQkfPYIIPYRVKDN 76
Cdd:COG3668   1 MKVRWTPEAEADLEEIYDYIAEDwGPEAAERYLDEIEEAIELLAEFPELGRPrpeLRVPGLRELVVG--PYVIFYRVDDD 78

                        90
                ....*....|....*.
gi 447088885 77 RIEILRVFPTRMNQPD 92
Cdd:COG3668  79 TVEILRVLHGRRDLPA 94
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
1-92 3.32e-20

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 77.24  E-value: 3.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447088885  1 MQIKWLKKALINLEHSAEYLQEQ-NPQSARDFVKEVHELTELLKANPAMGRP---GRVFGTRELILQkfPYIIPYRVKDN 76
Cdd:COG3668   1 MKVRWTPEAEADLEEIYDYIAEDwGPEAAERYLDEIEEAIELLAEFPELGRPrpeLRVPGLRELVVG--PYVIFYRVDDD 78

                        90
                ....*....|....*.
gi 447088885 77 RIEILRVFPTRMNQPD 92
Cdd:COG3668  79 TVEILRVLHGRRDLPA 94
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 3-89 6.99e-15

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 6.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447088885   3 IKWLKKALINLEHSAEYLQEQNPQSARDFVKEVHELTELLKANPAMGRPGRVFGTRELILQKF-PYIIPYRVKDNR--IE 79
Cdd:pfam05016  1 VILTPKALKDLKKIADYIAQDNPDAAERFLKALEEALELLAENPALGRPLPEGGLKGLRRIRIgDYRIIYRIDDDDlvIL 80

                         90
                 ....*....|
gi 447088885  80 ILRVFPTRMN 89
Cdd:pfam05016 81 ILRVGHRRRD 90
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
1-92 3.32e-20

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 77.24  E-value: 3.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447088885  1 MQIKWLKKALINLEHSAEYLQEQ-NPQSARDFVKEVHELTELLKANPAMGRP---GRVFGTRELILQkfPYIIPYRVKDN 76
Cdd:COG3668   1 MKVRWTPEAEADLEEIYDYIAEDwGPEAAERYLDEIEEAIELLAEFPELGRPrpeLRVPGLRELVVG--PYVIFYRVDDD 78

                        90
                ....*....|....*.
gi 447088885 77 RIEILRVFPTRMNQPD 92
Cdd:COG3668  79 TVEILRVLHGRRDLPA 94
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 3-89 6.99e-15

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 6.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447088885   3 IKWLKKALINLEHSAEYLQEQNPQSARDFVKEVHELTELLKANPAMGRPGRVFGTRELILQKF-PYIIPYRVKDNR--IE 79
Cdd:pfam05016  1 VILTPKALKDLKKIADYIAQDNPDAAERFLKALEEALELLAENPALGRPLPEGGLKGLRRIRIgDYRIIYRIDDDDlvIL 80

                         90
                 ....*....|
gi 447088885  80 ILRVFPTRMN 89
Cdd:pfam05016 81 ILRVGHRRRD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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