|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
5-394 |
0e+00 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 557.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 5 ATTPSKILDLTAAAFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLI 84
Cdd:PRK15011 6 AVSSAKSFDLTSTAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 85 LLCCLFGVLACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMFSTFLRAQISLAWVIGPPLAYE 164
Cdd:PRK15011 86 VFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGPPLAYA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 165 LAMGFSFKVMYLTAAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEIlPSTHRkRDTRLLFVVCSMMWAANNLYMINMPLFI 244
Cdd:PRK15011 166 LAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMRKELPLATGTLEA-PRRNR-RDTLLLFVICTLMWGTNSLYIINMPLFI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 245 IDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILC 324
Cdd:PRK15011 244 INELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAIYIGILG 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 325 GIGMLYFQDLMPEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLFIKDI 394
Cdd:PRK15011 324 GIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSLAGIVAEIWNYHAVFWFALVMIIATLFCLLRIKDV 393
|
|
| 2A0120 |
TIGR00899 |
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, ... |
18-393 |
0e+00 |
|
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129977 Cd Length: 375 Bit Score: 550.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 18 AFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTL 97
Cdd:TIGR00899 1 AFLLVAFLTGIAGALQFPTLSLFLSEEVRARPAMIGLFYTGSAIVGIAVSQLLATRSDYQGDRKGLILFCCLLAALACLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 98 FAWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMFSTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLT 177
Cdd:TIGR00899 81 FAWNRNYFLLLVLGVLLSSFASTANPQLFALAREHADRTGREAVMFSSVMRAQISLAWVIGPPLAFWLALGFGFTVMFLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 178 AAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEIlPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGE 257
Cdd:TIGR00899 161 AALAFVLCGVLVWLFLPSYPRGAPGALTRLEV-RGLLASRDTRLLFVACTLMWGCNILYIINMPLLIIHELGLPDKLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 258 MIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPE 337
Cdd:TIGR00899 240 MMGTAAGLEIPFMLLAGYLIKRFGKRRLMLLAALAGVAFYTGLAADNSLWALLMLQLLNAIFIGILAGIGMLYFQDLMPG 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447095620 338 KIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLFIKD 393
Cdd:TIGR00899 320 RAGAATTLYTNTGRVGWIIAGSVGGILAERWSYHAVYWFAIVMLIVALFCLLLIKD 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
19-389 |
4.25e-144 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 413.87 E-value: 4.25e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 19 FLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLF 98
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLSTGVLLSSFASTANPQMFALAREHADR-TGRETVMFSTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLT 177
Cdd:cd17471 81 AFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 178 AAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEiLPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGE 257
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAQKATPASS-LVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 258 MIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPE 337
Cdd:cd17471 240 LFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPG 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447095620 338 KIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLL 389
Cdd:cd17471 320 QPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-389 |
2.60e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 108.67 E-value: 2.60e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 19 FLLVAFLTGIAGALQTPTLSIFLADeLKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGdRKLLILLCCLFGVLACTLF 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAM--GFSFKVMYL 176
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRAL--GLLQAFGSVGGILGPLLGGILASslGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 177 TAAIAFVVCGLIVWLFLPSIQRNIPVVTQP------VEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDELHL 250
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEassksvLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 251 TDKLAGEMIGIAAGLEIPMMLIAGYYMKR-IGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGML 329
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447095620 330 YFQDLMPEKI-GSATTLYANTSRVGWIIAGSVDGIM-VEIWSYHALFWLAIGMLGIAMICLL 389
Cdd:cd06174 317 LIAELFPPEIrGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-357 |
4.01e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 4.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 6 TTPSKILDLTAAAFLLVAFLTGIAGALQTPTLSiFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLIL 85
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 86 LCCLFGVlACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMfsTFLRAQISLAWVIGPPLAYEL 165
Cdd:COG2814 81 GLLLFAL-GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 166 AMGFSFKVMYLTAAIAFVVCGLIVWLFLPSIQRniPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFII 245
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESRP--AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 246 DELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCG 325
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315
|
330 340 350
....*....|....*....|....*....|...
gi 447095620 326 IGMLYFQDLMPEKI-GSATTLYANTSRVGWIIA 357
Cdd:COG2814 316 LLQALVAELAPPEArGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-357 |
6.03e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.87 E-value: 6.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 19 FLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGvLACTLF 98
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFA-LGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTA 178
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRAL--GLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 179 AIAFVVCGLIVWLFLP----SIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFiIDELHLTDKL 254
Cdd:pfam07690 158 AILSLLAAVLLLLPRPppesKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 255 AGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMA---TTPAVELELQILNAIFLGILCGIGMLYF 331
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*..
gi 447095620 332 QDLMP-EKIGSATTLYANTSRVGWIIA 357
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-392 |
6.59e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 90.33 E-value: 6.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 19 FLLVAFLTGIAGALQTPTLSIFlADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGdRKLLILLCCLFGVLACTLF 98
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-RKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVM--FSTFlraqISLAWVIGPPLAYELAMGFSFKVMYL 176
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMgiFSSA----IGLGFLIGPLLGGLLADALGYRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 177 TAAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINM----PLFIIDELHLTD 252
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALepflPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 253 KLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQ 332
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447095620 333 DLMP-EKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLFIK 392
Cdd:cd17325 315 DIVPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-389 |
1.93e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 86.06 E-value: 1.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 11 ILDLTAAAFLLVAFLTGIAGALQTptlsifLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLF 90
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPD------IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 91 gVLACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALARE--HADRTGRETVMFSTFLraqiSLAWVIGPPLAYELAMG 168
Cdd:cd17324 75 -ILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADlvPPEKRGRAIGLVFSGL----TLGLVLGRPLGGLLGQL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 169 FSFKVMYLTAAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDEL 248
Cdd:cd17324 150 LGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 249 HLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGM 328
Cdd:cd17324 230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQ 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447095620 329 LYFQDLMPEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLL 389
Cdd:cd17324 310 TRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-392 |
2.66e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 83.03 E-value: 2.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 18 AFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSD----KQGDRKLLILLCCLFGVL 93
Cdd:COG2211 14 AYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 94 ACTLFAWNRN------YFILLSTGVLLSSFASTANPQMFALArehADRTG--RETVMFSTFLRAQISLAWVIGPPLAYEL 165
Cdd:COG2211 94 SFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLVNIPYSALG---AELTPdyEERTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 166 AMGFS------FKVMYLTAAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMIN 239
Cdd:COG2211 171 VAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 240 MPLFIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYasVLMATTPAVELELQILNAIF 319
Cdd:COG2211 251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL--LLLFFLGPGNLWLLLVLAAL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 320 LGILCGIGMLYFQDLMPEKI------------GSATTLYANTSRVGWIIAGSVDGIMVEIWSYHA--------------- 372
Cdd:COG2211 329 AGIGLGAILVLPWAMLADVVdydewktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirll 408
|
410 420
....*....|....*....|
gi 447095620 373 LFWLAIGMLGIAMICLLFIK 392
Cdd:COG2211 409 FFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-391 |
4.29e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 78.81 E-value: 4.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 20 LLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGdRKLLILLCCLFGVLACTLFA 99
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG-RKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 100 WNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGREtvMFSTFLRAQISLAWVIGPPLAYELAMgFSFKVMYLTAA 179
Cdd:cd17329 84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRT--RAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 180 IAFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMM--WAANNLYMINMPLFIIDELHLTDKLAGE 257
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFliSLIYFQLESTLPVYVVEILGLGESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 258 MIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVelelqilnAIFLGILCGIG-MLYF----- 331
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAV--------LILAMIVLTLGeMLVFpavqt 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447095620 332 --QDLMPE-KIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLFI 391
Cdd:cd17329 313 lvAALAPPdKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-390 |
8.26e-13 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 68.76 E-value: 8.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 20 LLVAFLTGIAGALQTPTLSIFLADELK--ARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKllILLCCLFGVLAC-T 96
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNKlgASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKP--VLLLSLAGSAVSyV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 97 LFAWNRNYFILLSTGVLLSSFASTaNPQMFALAREHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAMGFSFKVMYL 176
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAF--GIISAAFGLGFILGPALGGFLSTPYGYALPFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 177 TAAIAFVVCGLIVWLFLPSIqrnipvvtqpveilpsthrkrdtRLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAG 256
Cdd:cd17330 157 VAAALALLNLVLVLFFLPPL-----------------------RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 257 EMIGIAAGLEIPM-MLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGIL-CGIGMLYFQDL 334
Cdd:cd17330 214 LLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVfPALSALLSKSV 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447095620 335 MPEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLF 390
Cdd:cd17330 294 PSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
50-392 |
9.74e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.74 E-value: 9.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 50 IMVGFFFTGSAIMGILVSQFLARHSdkqgdRKLLILLCCLFGVLACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALA 129
Cdd:COG2271 49 LLASAFFLGYALGQIPAGLLADRFG-----RRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 130 REHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTAAIAFVVCGLIVwlflpsiqrnipvvtqpvei 209
Cdd:COG2271 124 AEWFPPKERGRAL--GIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLR-------------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 210 lpsthrkrdTRLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKR--LLML 287
Cdd:COG2271 182 ---------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 288 IAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEKI-GSATTLYANTSRVGWIIAGSVDGIMVE 366
Cdd:COG2271 253 IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
330 340
....*....|....*....|....*.
gi 447095620 367 IWSYHALFWLAIGMLGIAMICLLFIK 392
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLALLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-392 |
2.31e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.96 E-value: 2.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 14 LTAAAFLLVAFLTGIAGALQTPTLSIFLADELKARpIMVGFFFTGSAIMGILVSQFLARHSdkqgdRKLLILLCCLFGVL 93
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAG-LLLFAFFLGYLLASLPAGRLIDRFG-----YKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 94 ACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRetvMFSTFLRAQISLAWVIGP---PLAYELAMGFS 170
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA---SRLNLLHAFFSLGALLGPllgGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 171 FKVMYLTAAIAFVVCGLIVWLF-LPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDELH 249
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 250 LTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGML 329
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFS 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447095620 330 YFQDLMPEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLFIK 392
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-193 |
6.67e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 6.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 17 AAFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGdRKLLILLCCLFGVLACT 96
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG-RKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 97 LFAWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVM--FSTFLraqiSLAWVIGPPLAYELAMGFSFKVM 174
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMglFNTAF----SLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....*....
gi 447095620 175 YLTAAIAFVVCGLIVWLFL 193
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-390 |
1.32e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 65.33 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 18 AFLLVAFLTGIAGALQTPTLSIFLADeLKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTL 97
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 98 FAW----NRNYFILLSTGVLLSSFASTANPQMFALAREHADRtgRETVMFSTFLRAQISLAWVIGPPLAYELAMGFSFKV 173
Cdd:cd06173 82 ALLallgSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPK--EQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 174 MYLTAAIAFVVCGLIVWL-----FLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDEL 248
Cdd:cd06173 160 AFAINALSFLLSALLLLFirrppPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 249 HLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVsgMCFYASVLMATTPAveLELQILNAIFLGILCGIGM 328
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGAL--LLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447095620 329 LYFQDLM-----PEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWL-AIGMLGIAMICLLF 390
Cdd:cd06173 316 VPLNTLLqlrvpDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLaGALLLLAALLLLLL 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-392 |
7.75e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.81 E-value: 7.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 16 AAAFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVlAC 95
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI-GL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 96 TLFAWNRNYFILLSTGVLL-----SSFASTAN--PQMFAlarehADRTGRETVMFSTFLraqiSLAWVIGPPLAYELAMG 168
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLgigggGSFAVGIAlvSKWFP-----PDRRGLALGLAAGGG----NLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 169 FSFKVMYLTAAIAFVVCGLIVWLFLPSIQRNIPVV-TQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDE 247
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAaKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 248 LHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVeleLQILNAIFLGILCGIG 327
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLW---LFLVLFLLLGLALGGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447095620 328 MLYFQDLMPE-----KIGSATTLYANTSRVGWIIAGSVDGIMVEIW-SYHALFWLAIGMLGIAMICLLFIK 392
Cdd:COG2223 313 NGAVFALVPDifptkNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-390 |
2.15e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 20 LLVAFLTGIAGALQTPTLSIFLADeLKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGvLACTLFA 99
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFA-LATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 100 WNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMFSTFLraQISLAWVIGPPLAYELAMGFSFKVMYLTAA 179
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGL--ATTLAMALGPALGLFLYQHLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 180 iafvVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINM---PLFIIDELHltdKLAG 256
Cdd:cd17489 158 ----VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIStflPLYAAERGI---SNAG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 257 EMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELelqiLNAIFLGILCGIGMLYFQDLM- 335
Cdd:cd17489 231 LFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLL----LAAVLYGLGFGLLFPALQALAv 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447095620 336 ----PEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLF 390
Cdd:cd17489 307 dlvpPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
222-393 |
3.01e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.73 E-value: 3.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 222 LFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVL 301
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 302 MATTPAVELELQILNAIFLGILCGIGMLYFQDLMP-EKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGM 380
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|...
gi 447095620 381 LGIAMICLLFIKD 393
Cdd:pfam07690 161 SLLAAVLLLLPRP 173
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
211-390 |
3.42e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.59 E-value: 3.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 211 PSTHRKRDTRLLFVVCSMMWAANNLYMINMPLfIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAI 290
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 291 VSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMP-EKIGSATTLYANTSRVGWIIAGSVDGIMVEIWS 369
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180
....*....|....*....|.
gi 447095620 370 YHALFWLAIGMLGIAMICLLF 390
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-389 |
4.25e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.48 E-value: 4.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 40 FLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGdRKLLILLCCLFGVLACTLFAWNRNYFILLsTGVLLSSFAS 119
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKP-RRYLLPLGPLLTGLGLSLLGFAPNYWLLL-LLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 120 TA-NPQMFALAREHA-DRTGRETVMFSTFLraqiSLAWVIGPPLAYELAMGFSFKVMYLTAAIAFVVCGLIVWLFLPSIQ 197
Cdd:cd17478 99 AAfHPEGARLASQAAgGRRGLAMSIFSVGG----NLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 198 RNIPVVTQPVEIlPSTHRKRDTRLLFVVCSMM---WAANNLyMINMPLFIIDELhLTDKLAGEMIGIAAGLEIPMMLIAG 274
Cdd:cd17478 175 PEAKKAAAKSSA-RSTLKGVWRALLLLLIIVFlrsWVLSSL-TTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 275 YYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILcGIGMLYFQDLMPEKIGSATTLYANTSRVGW 354
Cdd:cd17478 252 PLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASF-PVTVVLAQELLPGNVGLASGLMMGLSFGLG 330
|
330 340 350
....*....|....*....|....*....|....*
gi 447095620 355 IIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLL 389
Cdd:cd17478 331 GIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
4-391 |
8.42e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.72 E-value: 8.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 4 TATTPSKILDLTAAAFLLVAFLTGIAGALQTPTLSI-----FLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQG 78
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVgpllpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 79 DRKLlILLCCLFGVLACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALAREH-ADRTGRETVMFSTFLraqiSLAWVI 157
Cdd:COG2807 82 LERT-LLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWfPDRVGLMTGLYTAAM----GLGAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 158 GPPLAYELAMGFSFKVMYLTAAIaFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLL---FVVCSMMWaann 234
Cdd:COG2807 157 AAGLTVPLAAALGWRGALAVWAL-LALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLtlfFGLQSLLY---- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 235 lYMIN--MPLFIIDeLHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIG-KRLLMLIAIVSGMCFYASVLMATTPAVele 311
Cdd:COG2807 232 -YAVVawLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLP--- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 312 lqILNAIFLGILCG----IGMLYFQDLMPEkIGSATTLYANTSRVGWIIAGS---VDGIMVEIW-SYHALFWLAIGMLGI 383
Cdd:COG2807 307 --WLWAVLLGLGQGglfpLALTLIGLRART-PAEAAALSGMAQSVGYLLAALgplLVGALHDATgSWTAALLLLAALAVL 383
|
....*...
gi 447095620 384 AMICLLFI 391
Cdd:COG2807 384 MLVAGLLA 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-192 |
1.62e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 37 LSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLFAWNRNYFILLSTGVLLSS 116
Cdd:cd17474 221 LPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL 300
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447095620 117 FASTANPQMFALAREHADRTGRETVM--FSTFLRaqisLAWVIGPPLAYELAMGFSFKVMYLTAAIAFVVCGLIVWLF 192
Cdd:cd17474 301 GLGLNLPLLTTLVTELAPEEERGTASslYNFVRF----LGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-184 |
2.40e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.20 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 19 FLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLF 98
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTA 178
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ--GIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
....*.
gi 447095620 179 AIAFVV 184
Cdd:cd17330 337 AGLLLI 342
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
61-391 |
4.89e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 51.43 E-value: 4.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 61 IMGILVSQFLARHSDKQGDRKLLILLCCLFGVLA-CTLFAWNRNYFILLSTGVLLSSFASTANPQM----FALAREHADR 135
Cdd:cd17335 43 FVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFfLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVdsitLQYLGEERER 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 136 TGREtvmfstflRAQISLAWVIGPPLAYELAMGFSFKVMYLTAAIAFVV---CGLIVWLFLPSIQRNIPVVTQPVEILPS 212
Cdd:cd17335 123 YGKQ--------RLWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAVlmlLALLLALKFPFRPKHPEPNENTGGLLAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 213 THRKRDTRLLFVVCSM--MWAANNLYminmpLFI-IDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIA 289
Cdd:cd17335 195 LRNPRVLAFLLVAFLMgfGHGLIYSF-----LFWhLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 290 IVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEKIGSA--TTLYANTSRVGWIIAGSVDGIMVEI 367
Cdd:cd17335 270 LLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATaqGLLQGLYFGLGGGLGSLIGGYLYEA 349
|
330 340
....*....|....*....|....
gi 447095620 368 WSYHALFWLAiGMLGIAMICLLFI 391
Cdd:cd17335 350 FGARTTFRFF-AIAALAGLLAFFL 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-391 |
1.95e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 17 AAFLLVAFLTGIAGALQTPTLSIfLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVlACT 96
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI-GGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 97 LFAWNRNYFILLST----GVLLSSFASTANPQMFALAREHAdrtgRETVMfsTFLRAQISLAWVIGPPLAYELAMgFSFK 172
Cdd:cd17474 80 LCGLSDSFALLLAGralqGIGAAGLGPLALTLIGDLFEGGE----RAKAM--GLYEAALGLGIAVGPLLGGLLAA-ISWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 173 VMYLTAAIAFVVcGLIVWLFLPSIQRNiPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMpLFIIDELHLTD 252
Cdd:cd17474 153 YPFFLLAALIPV-AFLAILFLLPEPKE-KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFL-TYLPFLLELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 253 KLAGEMIGIAAGLEIPMMLIAGYYMKRI-GKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYF 331
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447095620 332 QDLMPEKI-----GSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLFI 391
Cdd:cd17474 310 TTLVTELApeeerGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
228-393 |
2.70e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.13 E-value: 2.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 228 MMWAANNLYMINMPLFIIDeLHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPA 307
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 308 VELELQILNAIFLGILCGIGMLYFQDLMPEK-IGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMI 386
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSrRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
....*..
gi 447095620 387 CLLFIKD 393
Cdd:cd17489 166 LVFLVKD 172
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-391 |
3.92e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.42 E-value: 3.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 16 AAAFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGI---LVSQFLARHSDKQGDRKLLILLCCLFGv 92
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLafgLAQPFVGRLLDRFGPRRVMLLGLLLLA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 93 LACTLFAWNRNYFIL-LSTGVLLSSFASTANPQMFALAREHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAMGFSF 171
Cdd:cd17355 80 AGLVLLALATSLWQLyLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLAL--GILTAGGGLGSLVFLPLGAALIEAFGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 172 KVMYLTAAIAFVVCGLIVWLFL-------PSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFI 244
Cdd:cd17355 158 RTALLVLALLALLVLVPVLLLLrrrpadlALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 245 IDeLHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELelqILNAIFLGILC 324
Cdd:cd17355 238 AD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLAL---LLFAALFGLGW 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447095620 325 G-----IGMLYFQDLMPEKIGSATTLYANTSRVGWIIAGSVDGIMVE-IWSYHALFWLAIGMLGIAMICLLFI 391
Cdd:cd17355 314 GatvplTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDrTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
168-389 |
1.25e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 168 GFSFKVMYLTAAIAFVVCGLIVWLFLPSIQRN----IPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLF 243
Cdd:cd17316 124 GFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTY 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 244 IIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYA--SVLMATTPAVELELQILNAIFLG 321
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALplFYLLSGSPTLLLLLLFILSFFVG 283
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 322 ILCGIGMLYFQDLMPEKI-GSATTLYANTSRVGWIIAGS-VDGIMVEIWSYHALFWLAIGMLGIAMICLL 389
Cdd:cd17316 284 GVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPlIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
225-393 |
1.68e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 225 VCSMMWAANNLYMINMPLF--IIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLM 302
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILplYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 303 ATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEKIGSATTLYANTS-RVGWIIAGSVDGIMVEIWSYHALFWLAIGML 381
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAiGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170
....*....|..
gi 447095620 382 GIAMICLLFIKD 393
Cdd:cd17325 161 LLALVLALLLLP 172
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-193 |
2.76e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.66 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 20 LLVAFLTGIAGALQTptlsiFLADELKARPI-MVGFFFTGSAIMGILVSQFLARHSDKQGdRKLLILLCCLFGVLACTLF 98
Cdd:cd17489 201 LILFLASIAYGAIST-----FLPLYAAERGIsNAGLFFTVYAIALLLSRPFSGKLSDRKG-PKTVIIPGLLLLALGLLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLSTGVLLSSFASTANP--QMFALAREHADRTGRETVMFSTFLRAQISlawvIGPPLAYELAMGFSFKVMYL 176
Cdd:cd17489 275 SFAGSPWMLLLAAVLYGLGFGLLFPalQALAVDLVPPHRRGAANGTFFIFFDLGIG----LGGLLLGLVAELFGYRAMFL 350
|
170
....*....|....*..
gi 447095620 177 TAAIAFVVCGLIVWLFL 193
Cdd:cd17489 351 LAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
21-390 |
1.10e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 44.15 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 21 LVAFLTGIAGALQTPTLSIFLaDELKARPIMVGFFFTGSAIMGILVSQFLARHSD----KQGDRKLLILLCCLFGVLACT 96
Cdd:cd17313 6 FGFFGIEFGWALENSYVPPIL-QTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDrcnsRIGRRRPFILVGAPLAALGLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 97 LFAWNRNYFILLST------------GVLLSSFASTANPQ-----MFALAREHADRTGREtvMFSTFLRAQISLAWVIGP 159
Cdd:cd17313 85 LIPNAADIGLALGDgprtwalvlfvlGIVLLDFAMNVCQGpvralLPDLVPPEQRSKANG--IINFMGGLGGVLGYLLGA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 160 PLAYELAMGF----SFKVMYLTAAIAFVVCGLIVWLF-----LPSIQRNIPVVTQPVEILPS-----THRKRDTRLLFVV 225
Cdd:cd17313 163 ILWDHNWFGFalggNLKVPFYIGAIILLVCVLVTLFFvkeppLSPEAGEHSENPSLGEVLKSllkllKIMPRSLLRLLLV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 226 CSMMWAANNLYMINMPLFIIDELHLTDKLAGEMIGIAAGLEIPMMLI-----------AGYYMKRIGKRLLMLIAIVSGM 294
Cdd:cd17313 243 IFFWWIAFFPFELFFTDYMGEEVYHGTSAASSHYGAGVRMGAWGLLIfslaflifslpIGKLGKKIGRKKVYLIGLVLFA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 295 CFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEK---IGSATTLYANTSRVGWIIAGSVDGIMVEIWSYH 371
Cdd:cd17313 323 VGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESgrgQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYG 402
|
410
....*....|....*....
gi 447095620 372 ALFWLAIGMLGIAMICLLF 390
Cdd:cd17313 403 TVFPVAAVASFLSLVGALF 421
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-389 |
1.17e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 35 PTLSIFLADELKARPIMVGFFFTGSAImGILVSQFLA-RHSDKQGDRKLLILLCCLFGVLACtLFAWNRNYFILLSTGVL 113
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLLLSALNL-GVAVSMLPAgWLLDRFGERRVLAVGLLLMGAAAL-LMALVGSYPVLLVLLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 114 LSSFASTANPQMFALAREHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTAAIAFVVCGLIVWLFL 193
Cdd:cd17475 94 VGAGYGSVQPGGGRAIMRWFPPRERGLAM--GIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 194 ---PSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGEMIGIAAGLEIPMM 270
Cdd:cd17475 172 repPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 271 LIAGYYMKRIG-----KRLLMLIAIVSGMCFYASVLMATTPAVeleLQILNAIFLGILC----GIGMLYFQDLMP-EKIG 340
Cdd:cd17475 252 IGLGRVSDRVFggrrrPVLVITAAIAAAALLVLSLLSPGTPLW---LLVLLLILLGLFAigwnGLYLTLVAESAGpEQAG 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 447095620 341 SATTLYANTSRVGWIIAGSVDGIMVE-IWSYHALFWLAIGMLGIAMICLL 389
Cdd:cd17475 329 TALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
221-393 |
1.94e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.33 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 221 LLFVVCSMMWAANNLYMINMPlfiiDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIaivsGMCFYASV 300
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAPPLA----EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI----GLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 301 LMATTPAVELELQILNAIFLGILCGIGMLYFQDLM-----PEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFW 375
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVskwfpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170
....*....|....*....
gi 447095620 376 L-AIGMLGIAMICLLFIKD 393
Cdd:COG2223 164 IlGILLLVVAVLAWLFLRD 182
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
20-328 |
2.61e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.56 E-value: 2.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 20 LLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLFa 99
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 100 WNRNYFILLSTGVLLSSFASTANPQMFALAREHADRTGRETVMFstFLRAQISLAWVIGPPLAYELAmGFSFKVMYLTAA 179
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLG--LQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 180 IAFVVcGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGEMI 259
Cdd:cd17473 161 LALPV-LILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447095620 260 GIAAGleipMMLIAGYYMKRIGKRLL--MLIAIVSGMCFYASVLMATTPavELELQILNAIFLGILCGIGM 328
Cdd:cd17473 240 AIASL----AGAIGALLFGRLKRRLGkrRLLAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLL 304
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
21-389 |
2.92e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 21 LVAFLTGIAGALQTPTLSIFLAdELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLFAW 100
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLV-VLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 101 NRNYFILlstgVLLSSFASTA----NPQMFALAREHADRTGRETVmFStFLRAQISLAWVIGPPLAYEL--AMGFSFKVM 174
Cdd:cd17370 85 AGSWQLV----LLLRILERLGkgirTPPRDALLADATPPSGRGKA-FG-LHRALDTLGAVLGPLLAALLlyLLGGNYRTI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 175 YLTAAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEIlPSTHRKRDTRLLFVVCSMMWAANnlymINMPLFII--DELHLTD 252
Cdd:cd17370 159 FLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKT-SLKKLPKAFWLYLLAVALFALGN----FSFAFLILraQELGLSA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 253 KLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQ 332
Cdd:cd17370 234 ALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447095620 333 DLMPEKI-GSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLL 389
Cdd:cd17370 314 DLVPAELrGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
50-391 |
7.51e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.40 E-value: 7.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 50 IMVGFFFTGSAIMGILVSQFLarhsDKQGDRKLLILLCCLFGvLACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALA 129
Cdd:cd17319 42 LIASAFFLGYALFQVPGGWLL----DRFGARKVLAVSMLLWS-LFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 130 REHADRTGRETVMfsTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTAAIAFVVCGLIVWLFLPSIQrnipvvtqpvei 209
Cdd:cd17319 117 AEWFPARERGRAT--GLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVW------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 210 lpsthrkrdtrLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRI--GKRLLML 287
Cdd:cd17319 183 -----------GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 288 IAIVS-GMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEK-IGSATTLYANTSRVGWIIAGSVDGIMV 365
Cdd:cd17319 252 IIGLLlAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEaAATAGGLINSGGNLGGFVAPLLIGYLV 331
|
330 340
....*....|....*....|....*..
gi 447095620 366 EIW-SYHALFWLAIGMLGIAMICLLFI 391
Cdd:cd17319 332 DATgSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
231-391 |
8.89e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 8.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 231 AANNLYMInMPLF--IIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAV 308
Cdd:cd17324 11 IGTTEYVI-QGLLpdIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 309 ELELQILNAIFLGILCGIGMLYFQDLMP-EKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMIC 387
Cdd:cd17324 90 LLLARALAGLAHGGFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169
|
....
gi 447095620 388 LLFI 391
Cdd:cd17324 170 LWRL 173
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
52-390 |
1.23e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.77 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 52 VGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLFAWNRNYFILLS---TGVLLSSFASTANPQMFAL 128
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLmflAGLGAGILDTGANTFVGAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 129 AREhadrtGRETVMfsTFLRAQISLAWVIGPPLA-YELAMGFSFKVMYLTAAiAFVVCGLIVWLF-----LPSIQRNIPV 202
Cdd:cd17333 113 FEE-----SSATRL--NVLHGFFGLGALIGPLIAtSLLTSELSWSWAYLIIG-LIYLLLAILILLtlfpeLPSARNPQQS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 203 VTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINMPLFIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGK 282
Cdd:cd17333 185 VGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKP 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 283 RLLMLIAIVSGMCFYASVLMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEKIGSATTLYANTSRVGWIIAGSVDG 362
Cdd:cd17333 265 HTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
330 340
....*....|....*....|....*...
gi 447095620 363 IMVEIWSYHALFWLAIGMLGIAMICLLF 390
Cdd:cd17333 345 FIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
19-367 |
1.30e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.67 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 19 FLLVAFLTGIAGALQTPTLSIfLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGdRKLLILLCCLFGVLACTLF 98
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLST-HIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVG-RRPVLLICLLLTALGYVLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLSTGVLLSSFASTANpqmfaLAREH-ADRTGRE--TVMFSTFlRAQISLAWVIGPPLAYELAM---GFsFK 172
Cdd:cd17390 79 GFSTSLALLFLSRIPLGIFKHTQS-----LCKAYlSDLVSEQerSRVLGRF-NAASSLGFILGPVVGGHLAEtdgGF-YY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 173 VMYLTAAIaFVVCGLIVWLFLPSIqrnipvvtqpveilpsthrkrdtRLLFVVCSMMWAANNLYMINMPLFIIDELHLTD 252
Cdd:cd17390 152 VALLCSAI-FILNAGLVWFLLSKL-----------------------WDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 253 KLAGEMIGIAAGLEIPMMLIAGYYMKRIGK---RLLMLIAIVSGMCFYASVLmattpAVELELQILNAIFLGILCGIGML 329
Cdd:cd17390 208 KTIGYLISYSGVLGALSGFLVGRILKLYKNneyLLLLHSFILLALSLLGLAL-----APSIWLLVLCLTPLSISSAVLRT 282
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 447095620 330 YFQDLM-----PEKIGSATTLYANTSRVGWIIAGSVDGIMVEI 367
Cdd:cd17390 283 CSTSLLlsrgkSKERGTLLGVGQSVTSLARILAPLLSGLLQEF 325
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
74-391 |
3.41e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.10 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 74 SDKQGDRKLLILLCCLFgVLACTLFAWNRNYFILLSTGVLLSSFASTANPQMFALAREHADrtGRETVMFSTFLRAQISL 153
Cdd:cd17320 58 SDRFGRRPVLLAGLLLF-ILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS--GAELAKIFSLLMMILAI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 154 AWVIGPPLAYELAMGFSFKVMYLTAAIAFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRK-RDTRLLF--VVCSMMW 230
Cdd:cd17320 135 APALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVlKNRRFLGyaLALGLSF 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 231 AANNLYMINMPLFIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFyASVLMATTPAVEL 310
Cdd:cd17320 215 AGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAA-ALVLLLAALLGGL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 311 ELQILNAIFLGILCGIGMLY------FQDLMPEKIGSATTLYaNTSRVGwiIAGSVDGIMVEIWS-YHALFWLAIGMLGI 383
Cdd:cd17320 294 SLWPLVAPLFLIFFGFGLIFpnatslALEPFPHVAGTASALL-GFLQFL--IGALAGALVGLLPNgTALPMGLLILVLGL 370
|
....*...
gi 447095620 384 AMICLLFI 391
Cdd:cd17320 371 LALLLLIL 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
336-393 |
6.49e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 6.49e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 447095620 336 PEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWSYHALFWLAIGMLGIAMICLLFIKD 393
Cdd:cd17490 115 PDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKE 172
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-392 |
7.49e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 7.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 19 FLLVAFLTGIAGALQTPTLSiFLADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFgVLACTLF 98
Cdd:cd17504 1 LALAALAVMLVETMLSPALP-TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIY-TAGSLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 99 AWNRNYFILLsTGVLLSSFASTANPQMFALAREHADRtgRETVMFSTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTA 178
Cdd:cd17504 79 AFAPNLPVLI-AGRALQGIGGAVFPLAFALVREEFPP--ERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 179 AIAFVVCGLIVWLFLPSIQRNIPVVTQPVeilpsthrkrdTRLLFVVCSMMWAANNLYMINMPlfiidelhlTDKLAGEM 258
Cdd:cd17504 156 APVAVLLAALVPLIDLRLLRRRNVLLANI-----------TALLAGFGMFMVFQLLPQLLQLP---------TPTGFGLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 259 IGIAAGLEIPMMLI-------AGYYMKRIGKRLLMLI-AIVSGMCFYASVLMATTPAVELELQILNAIFLGIL-CGIGML 329
Cdd:cd17504 216 ITEAGLLLLPGALVmliagplAGRLIARVGPRRVLLIgLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAfASLPNI 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447095620 330 YFQDLMPEKIGSATTLYANTSRVGWIIAGSVDGIMVEIWS-------------YHALFWLAIGMLGIAMICLLFIK 392
Cdd:cd17504 296 VVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTvsitsggvptegaYVLAFLIGAALALAALLLSLLIP 371
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
41-357 |
8.26e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.11 E-value: 8.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 41 LADELKARPIMVGFFFTGSAIMGILVSQFLARHSDKQGDRKLLILLCCLFGVLAC-TLFAWNRNYFILLS--TGVLLSSf 117
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLlCALATNVTQLLILRflAGLGLGG- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 118 astANPQMFALAREHADRTGRETVMFSTFLRAQISLAwvIGPPLAYELAMGFSFKVMYLTAAIAFVVCGLIVWLFLPS-- 195
Cdd:TIGR00895 122 ---LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAA--VGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPEsi 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 196 ----IQRNIPVVTQPVEILPSTHRK----------------------------RDTRLLFVVCSMMWAANNLYMINMPLF 243
Cdd:TIGR00895 197 dflvSKRPETVRRIVNAIAPQMQAEaqsalpeqkstqgtkrsvfkalfqgktaRITVLLWLLYFMLLVGVYFLTNWLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 244 IIDELHLTDKLAGEMIGIAAGLEIPMmLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATTPAVELELqilnAIFLGIL 323
Cdd:TIGR00895 277 MVELGFSLSLAATGGALFNFGGVIGS-IIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLL----GAIAGFF 351
|
330 340 350
....*....|....*....|....*....|....*..
gi 447095620 324 CGIGMLYFQDLMPEkigsattLYANTSR---VGWIIA 357
Cdd:TIGR00895 352 VNGGQSGLYALMAL-------FYPTAIRatgVGWAIG 381
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
18-305 |
8.37e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.06 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 18 AFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGS----AIMGILVSQFLARHSDKQGDRKLLILLCCLFGVL 93
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVArlvdAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 94 ACTLFAWNRN--------YFILLSTGV-LLSSFASTANPQMFA-LAREHADRTgRETVMFSTFLRAQISLAWVIGPPLAY 163
Cdd:pfam13347 81 SFILLFTPPElgraplfiWLLATYILLrIAYTFFEIPYWSLGPeLTRDYDERT-SLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447095620 164 ELAMGFSFKVMYLTAAIAFVVCGLIVWLFLPSIQRNIPVVTQPV-----------EILPSTHRKRDTRLLFVVCSMMWAA 232
Cdd:pfam13347 160 ILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEdtgqkeagsllDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447095620 233 NNLYMINMPLFIIDELHlTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASVLMATT 305
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGP 311
|
|
| |
