|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
4-258 |
1.31e-178 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 492.09 E-value: 1.31e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19133 1 VTLNNGVEMPILGFGVFQIPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPF 163
Cdd:cd19133 81 KAKKAFERSLKRLGLDYLDLYLIHQPFGDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 164 NQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILD 243
Cdd:cd19133 161 NQQIEAVEFLKKYGVQIEAWGPFAEGRNNLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFD 240
|
250
....*....|....*
gi 447097196 244 FELSPEDMLQITALD 258
Cdd:cd19133 241 FELSDEDMEAIAALD 255
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
8-271 |
4.99e-148 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 414.84 E-value: 4.99e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:COG0656 1 NGVEIPALGLGTWQLPGE-EAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAASGVPREELFVTTKVWNDNHGYDDTLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 88 QFERSLNRLQLDYVDLYLIHQPY-GDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQ 166
Cdd:COG0656 80 AFEESLERLGLDYLDLYLIHWPGpGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 167 LQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFEL 246
Cdd:COG0656 160 RELLAFCREHGIVVEAYSPLGRGK--LLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFEL 237
|
250 260
....*....|....*....|....*
gi 447097196 247 SPEDMLQITALDTATSAFFshrDPA 271
Cdd:COG0656 238 SDEDMAAIDALDRGERLGP---DPD 259
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
12-254 |
1.04e-124 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 355.64 E-value: 1.04e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 12 MPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKAQFER 91
Cdd:cd19071 1 MPLIGLGTYKLKPE-ETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESGVPREELFITTKLWPTDHGYERVREALEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 92 SLNRLQLDYVDLYLIHQPYGDVHG--------AWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPF 163
Cdd:cd19071 80 SLKDLGLDYLDLYLIHWPVPGKEGgskearleTWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 164 NQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILD 243
Cdd:cd19071 160 LQQKELVEFCKEHGIVVQAYSPLGRGRRPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFD 239
|
250
....*....|.
gi 447097196 244 FELSPEDMLQI 254
Cdd:cd19071 240 FELSEEDMAAI 250
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
4-258 |
1.78e-114 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 329.78 E-value: 1.78e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19126 1 VTLNNGTRMPWLGLGVFQTPDGDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRESGVPREELFVTTKLWNDDQRAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQPYGD-VHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNP 162
Cdd:cd19126 81 RTEDAFQESLDRLGLDYVDLYLIHWPGKDkFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPAVNQVEFHP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 163 FNQQLQAVPWMQSRGIQPEAWAPFAEGknGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINIL 242
Cdd:cd19126 161 YLTQKELRGYCKSKGIVVEAWSPLGQG--GLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIF 238
|
250
....*....|....*.
gi 447097196 243 DFELSPEDMLQITALD 258
Cdd:cd19126 239 DFELSEDDMTAIDALN 254
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
4-258 |
1.74e-112 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 325.13 E-value: 1.74e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQmTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19127 1 ITLNNGVEMPALGLGVFQ-TPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRSGVDRSDIFVTTKLWISDYGYD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQP----YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVE 159
Cdd:cd19127 80 KALRGFDASLRRLGLDYVDLYLLHWPvpndFDRTIQAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPAVNQVE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 160 VNPFNQQLQAVPWMQSRGIQPEAWAPF----------AEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKS 229
Cdd:cd19127 160 LHPYFSQKDLRAFHRRLGIVTQAWSPIggvmrygasgPTGPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKS 239
|
250 260
....*....|....*....|....*....
gi 447097196 230 VRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19127 240 VHPERIAENIDIFDFALSAEDMAAIDALD 268
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
3-259 |
5.20e-110 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 318.95 E-value: 5.20e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 3 KVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSY 82
Cdd:cd19157 1 TVTLNNGVKMPWLGLGVFKVEEGSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKESGIPREELFITSKVWNADQGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDV-HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVN 161
Cdd:cd19157 81 DSTLKAFEASLERLGLDYLDLYLIHWPVKGKyKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEFH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 162 PFNQQLQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINI 241
Cdd:cd19157 161 PRLTQKELRDYCKKQGIQLEAWSPLMQGQ--LLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADV 238
|
250
....*....|....*...
gi 447097196 242 LDFELSPEDMLQITALDT 259
Cdd:cd19157 239 FDFELSQEDMDKIDALNE 256
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
4-258 |
5.42e-104 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 303.14 E-value: 5.42e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19131 2 ITLNDGNTIPQLGLGVWQVSND-EAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRASGVPREELFITTKLWNSDQGYD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEV 160
Cdd:cd19131 81 STLRAFDESLRKLGLDYVDLYLIHWPvpaQDKYVETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 161 NPFNQQLQAVPWMQSRGIQPEAWAPFAEGknGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENIN 240
Cdd:cd19131 161 HPRFQQRELRAFHAKHGIQTESWSPLGQG--GLLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFD 238
|
250
....*....|....*...
gi 447097196 241 ILDFELSPEDMLQITALD 258
Cdd:cd19131 239 VFDFELDADDMQAIAGLD 256
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
4-259 |
1.10e-103 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 302.90 E-value: 1.10e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19156 1 VKLANGVEMPRLGLGVWRVQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRESGVPREEVFVTTKLWNSDQGYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNP 162
Cdd:cd19156 81 STLAAFEESLEKLGLDYVDLYLIHWPVKGKFkDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 163 FNQQLQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINIL 242
Cdd:cd19156 161 LLTQEPLRKFCKEKNIAVEAWSPLGQGK--LLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVF 238
|
250
....*....|....*..
gi 447097196 243 DFELSPEDMLQITALDT 259
Cdd:cd19156 239 DFELTAEEIRQIDGLNT 255
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
6-259 |
6.32e-100 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 293.02 E-value: 6.32e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 6 LNNGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGA 85
Cdd:cd19132 1 LNDGTQIPAIGFGTYPLKGD-EGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRRSGVPREELFVTTKLPGRHHGYEEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 86 KAQFERSLNRLQLDYVDLYLIHQP------YGDvhgAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVE 159
Cdd:cd19132 80 LRTIEESLYRLGLDYVDLYLIHWPnpsrdlYVE---AWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPAVNQIE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 160 VNPFNQQLQAVPWMQSRGIQPEAWAPFAEGkNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENI 239
Cdd:cd19132 157 LHPYFPQAEQRAYHREHGIVTQSWSPLGRG-SGLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENL 235
|
250 260
....*....|....*....|
gi 447097196 240 NILDFELSPEDMLQITALDT 259
Cdd:cd19132 236 AIFDFELSDEDMAAIAALDR 255
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
12-257 |
2.98e-97 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 286.45 E-value: 2.98e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 12 MPLLGFGVFQMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQS----GIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:cd19136 1 MPILGLGTFRLRGEEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLlpkyGLSREDIFITSKLAPKDQGYEKARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 88 QFERSLNRLQLDYVDLYLIH-------QPYGDVH-----GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAV 155
Cdd:cd19136 81 ACLGSLERLGTDYLDLYLIHwpgvqglKPSDPRNaelrrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 156 NQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERM 235
Cdd:cd19136 161 NQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGDLRLLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERI 240
|
250 260
....*....|....*....|..
gi 447097196 236 EENINILDFELSPEDMLQITAL 257
Cdd:cd19136 241 AENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
3-259 |
3.29e-96 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 284.95 E-value: 3.29e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 3 KVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNAL----KQSGIARNELFVTTKLWLQ 78
Cdd:cd19116 2 TIKLNDGNEIPAIALGTWKLKDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIrekiAEGVVKREDLFITTKLWNS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 79 DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19116 82 YHEREQVEPALRESLKRLGLDYVDLYLIHWPVAfkenndsesngdgslsdiDYLETWRGMEDLVKLGLTRSIGVSNFNSE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 141 RLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPF-------AEGKNGLFQHPVLTAIGEKYGKSVGQV 213
Cdd:cd19116 162 QINRLLSNCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFgrlvprgQTNPPPRLDDPTLVAIAKKYGKTTAQI 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 447097196 214 VLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALDT 259
Cdd:cd19116 242 VLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNT 287
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
4-257 |
4.23e-93 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 275.74 E-value: 4.23e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMtdAAECERAVIDAI-NSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSY 82
Cdd:cd19135 5 VRLSNGVEMPILGLGTSHS--GGYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAIKESGVPREDLFLTTKLWPSDYGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG---------AWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVP 153
Cdd:cd19135 83 ESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGknvketraeTWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 154 AVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKE 233
Cdd:cd19135 163 HVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGK--ALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEE 240
|
250 260
....*....|....*....|....
gi 447097196 234 RMEENINILDFELSPEDMLQITAL 257
Cdd:cd19135 241 RIKENCQVFDFSLSEEDMATLDSL 264
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
4-258 |
2.21e-92 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 274.64 E-value: 2.21e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDtsYE 83
Cdd:PRK11565 7 IKLQDGNVMPQLGLGVWQASNE-EVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEASVAREELFITTKLWNDD--HK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQP------YGDvhgAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQ 157
Cdd:PRK11565 84 RPREALEESLKKLQLDYVDLYLMHWPvpaidhYVE---AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 158 VEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEE 237
Cdd:PRK11565 161 IELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240
|
250 260
....*....|....*....|.
gi 447097196 238 NINILDFELSPEDMLQITALD 258
Cdd:PRK11565 241 NFDVFDFRLDKDELGEIAKLD 261
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
12-254 |
1.43e-87 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 261.05 E-value: 1.43e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 12 MPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKAQFER 91
Cdd:cd19073 1 IPALGLGTWQLRGD-DCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAESGVPREDLFITTKVWRDHLRPEDLKKSVDR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 92 SLNRLQLDYVDLYLIHQPYGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQA 169
Cdd:cd19073 80 SLEKLGTDYVDLLLIHWPNPTVPLEetLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAVNQVEFHPFLYQAEL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 170 VPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPE 249
Cdd:cd19073 160 LEYCRENDIVITAYSPLARGE--VLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSE 237
|
....*
gi 447097196 250 DMLQI 254
Cdd:cd19073 238 DVAKI 242
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
6-258 |
2.62e-87 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 261.00 E-value: 2.62e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 6 LNNGIEMPLLGFGVFQMTDAAEcERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGA 85
Cdd:cd19130 4 LNDGNSIPQLGYGVFKVPPADT-QRAVATALEVGYRHIDTAAIYGNEEGVGAAIAASGIPRDELFVTTKLWNDRHDGDEP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 86 KAQFERSLNRLQLDYVDLYLIHQPY---GDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNP 162
Cdd:cd19130 83 AAAFAESLAKLGLDQVDLYLVHWPTpaaGNYVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQIELHP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 163 FNQQLQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINIL 242
Cdd:cd19130 163 AYQQRTIRDWAQAHDVKIEAWSPLGQGK--LLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVF 240
|
250
....*....|....*.
gi 447097196 243 DFELSPEDMLQITALD 258
Cdd:cd19130 241 DFDLTDTEIAAIDALD 256
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
5-251 |
1.69e-85 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 257.27 E-value: 1.69e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 5 KLNNGIEMPLLGFGVFQmTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALK---QSGIA-RNELFVTTKLWLQDT 80
Cdd:cd19125 4 KLNTGAKIPAVGLGTWQ-ADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKklfEDGVVkREDLFITSKLWCTDH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 81 SYEGAKAQFERSLNRLQLDYVDLYLIHQPYG----------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19125 83 APEDVPPALEKTLKDLQLDYLDLYLIHWPVRlkkgahmpepeevlppDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLED 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 145 LIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPF-----AEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIY 219
Cdd:cd19125 163 LLAVARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLgspgtTWVKKNVLKDPIVTKVAEKLGKTPAQVALRWGL 242
|
250 260 270
....*....|....*....|....*....|..
gi 447097196 220 QRGIVSLAKSVRKERMEENINILDFELSPEDM 251
Cdd:cd19125 243 QRGTSVLPKSTNEERIKENIDVFDWSIPEEDF 274
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
9-256 |
2.33e-84 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 253.69 E-value: 2.33e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGV----FQMTDAA---ECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTS 81
Cdd:cd19120 1 GSKIPAIAFGTgtawYKSGDDDiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKESGVPREDLFITTKVSPGIKD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 82 YEGAkaqFERSLNRLQLDYVDLYLIHQPY------GDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAV 155
Cdd:cd19120 81 PREA---LRKSLAKLGVDYVDLYLIHSPFfakeggPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 156 NQVEVNPF--NQQLQAVPWMQSRGIQPEAW---APFAEGKNGLFQhPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSV 230
Cdd:cd19120 158 NQIEFHPYlyPQQPALLEYCREHGIVVSAYsplSPLTRDAGGPLD-PVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTSS 236
|
250 260
....*....|....*....|....*.
gi 447097196 231 RKERMEENINILDFELSPEDMLQITA 256
Cdd:cd19120 237 KEERMKEYLEAFDFELTEEEVEEIDK 262
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
8-257 |
5.03e-84 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 252.56 E-value: 5.03e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:cd19140 4 NGVRIPALGLGTYPLTGE-ECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIAASGVPRDELFLTTKVWPDNYSPDDFLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 88 QFERSLNRLQLDYVDLYLIHQPYGDVHGAW--RAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQ 165
Cdd:cd19140 83 SVEESLRKLRTDYVDLLLLHWPNKDVPLAEtlGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFTNQVEYHPYLD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 166 Q---LQAVpwmQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQR-GIVSLAKSVRKERMEENINI 241
Cdd:cd19140 163 QrklLDAA---REHGIALTAYSPLARGE--VLKDPVLQEIGRKHGKTPAQVALRWLLQQeGVAAIPKATNPERLEENLDI 237
|
250
....*....|....*.
gi 447097196 242 LDFELSPEDMLQITAL 257
Cdd:cd19140 238 FDFTLSDEEMARIAAL 253
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
4-261 |
1.00e-83 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 252.08 E-value: 1.00e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYE 83
Cdd:cd19134 3 VTLNDDNTMPVIGLGVGELSDD-EAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIPRGELFVTTKLATPDQGFT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVH---GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEV 160
Cdd:cd19134 82 ASQAACRASLERLGLDYVDLYLIHWPAGREGkyvDSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTFFTPAVNQIEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 161 NPFNQQLQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENIN 240
Cdd:cd19134 162 HPLLNQAELRKVNAQHGIVTQAYSPLGVGR--LLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLD 239
|
250 260
....*....|....*....|.
gi 447097196 241 ILDFELSPEDMLQITALDTAT 261
Cdd:cd19134 240 VFDFELTADHMDALDGLDDGT 260
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
8-257 |
7.84e-81 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 245.26 E-value: 7.84e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGVF-QMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQ---SG--IARNELFVTTKLWLQDTS 81
Cdd:cd19124 1 SGQTMPVIGMGTAsDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEalrLGlvKSRDELFVTSKLWCSDAH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 82 YEGAKAQFERSLNRLQLDYVDLYLIHQPYG------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:cd19124 81 PDLVLPALKKSLRNLQLEYVDLYLIHWPVSlkpgkfsfpieeedflpfDIKGVWEAMEECQRLGLTKAIGVSNFSCKKLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 144 DLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAE-----GKNGLFQHPVLTAIGEKYGKSVGQVVLRWI 218
Cdd:cd19124 161 ELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGApgtkwGSNAVMESDVLKEIAAAKGKTVAQVSLRWV 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 447097196 219 YQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITAL 257
Cdd:cd19124 241 YEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
4-264 |
2.24e-80 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 245.01 E-value: 2.24e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTdAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQ---SGI-ARNELFVTTKLWLQD 79
Cdd:cd19154 4 ITLSNGVKMPLIGLGTWQSK-GAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAElleEGVvKREDLFITTKLWTHE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG---------------------DVHGAWRAMEELQQAGKIRAIGVSNFH 138
Cdd:cd19154 83 HAPEDVEEALRESLKKLQLEYVDLYLIHAPAAfkddegesgtmengmsihdavDVEDVWRGMEKVYDEGLTKAIGVSNFN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 139 PDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPF--------------AEGKNgLFQHPVLTAIGE 204
Cdd:cd19154 163 NDQIQRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLgspgranftkstgvSPAPN-LLQDPIVKAIAE 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 205 KYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALDTATSAF 264
Cdd:cd19154 242 KHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRLF 301
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
6-259 |
6.25e-80 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 243.83 E-value: 6.25e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 6 LNNGIEMPLLGFGVFQmTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQS-----GIARNELFVTTKLWLQDT 80
Cdd:cd19106 1 LHTGQKMPLIGLGTWK-SKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKvgpgkAVPREDLFVTSKLWNTKH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 81 SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG---------------------AWRAMEELQQAGKIRAIGVSNFHP 139
Cdd:cd19106 80 HPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGdnpfpknpdgtirydsthykeTWKAMEKLVDKGLVKAIGLSNFNS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 140 DRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPF--------AEGKNGLFQHPVLTAIGEKYGKSVG 211
Cdd:cd19106 160 RQIDDILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLgspdrpwaKPDEPVLLEEPKVKALAKKYNKSPA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 447097196 212 QVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALDT 259
Cdd:cd19106 240 QILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNR 287
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
5-257 |
6.56e-79 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 240.48 E-value: 6.56e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 5 KLNNGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWlqDTSYEG 84
Cdd:cd19117 7 KLNTGAEIPAVGLGTWQSKPN-EVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIKDSGVPREEIFITTKLW--CTWHRR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 85 AKAQFERSLNRLQLDYVDLYLIHQPYG-----------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDR 141
Cdd:cd19117 84 VEEALDQSLKKLGLDYVDLYLMHWPVPldpdgndflfkkddgtkdhepdwDFIKTWELMQKLPATGKVKAIGVSNFSIKN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 142 LADLIA--FNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIY 219
Cdd:cd19117 164 LEKLLAspSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGSTNAPLLKEPVIIKIAKKHGKTPAQVIISWGL 243
|
250 260 270
....*....|....*....|....*....|....*...
gi 447097196 220 QRGIVSLAKSVRKERMEENINIldFELSPEDMLQITAL 257
Cdd:cd19117 244 QRGYSVLPKSVTPSRIESNFKL--FTLSDEEFKEIDEL 279
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
1-258 |
5.17e-78 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 238.46 E-value: 5.17e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKLNNGIEMPLLGFGVFQmTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNAL----KQSGIARNELFVTTKLW 76
Cdd:cd19123 1 MKTLPLSNGDLIPALGLGTWK-SKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALaevfKEGKVKREDLWITSKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 77 LQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGA--------------------WRAMEELQQAGKIRAIGVSN 136
Cdd:cd19123 80 NNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKGVgfpesgedllslspipledtWRAMEELVDKGLCRHIGVSN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 137 FHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPF----------AEGKNGLFQHPVLTAIGEKY 206
Cdd:cd19123 160 FSVKKLEDLLATARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLgsgdrpaamkAEGEPVLLEDPVINKIAEKH 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 447097196 207 GKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19123 240 GASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALD 291
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
4-258 |
8.21e-78 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 238.54 E-value: 8.21e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMtDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNAL----KQSGIARNELFVTTKLWlqD 79
Cdd:cd19112 3 ITLNSGHKMPVIGLGVWRM-EPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALaeafKTGLVKREDLFITTKLW--N 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-------------------------GAWRAMEELQQAGKIRAIGV 134
Cdd:cd19112 80 SDHGHVIEACKDSLKKLQLDYLDLYLVHFPVATKHtgvgttgsalgedgvldidvtisleTTWHAMEKLVSAGLVRSIGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 135 SNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGL--------FQHPVLTAIGEKY 206
Cdd:cd19112 160 SNYDIFLTRDCLAYSKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGGAAANAewfgsvspLDDPVLKDLAKKY 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 447097196 207 GKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19112 240 GKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLD 291
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
9-264 |
1.36e-70 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 219.29 E-value: 1.36e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGVFQMTdAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALK---QSG-IARNELFVTTKLWLQDTSYEG 84
Cdd:cd19111 1 GFPMPVIGLGTYQSP-PEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKwwlKNGkLKREEVFITTKLPPVYLEFKD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 85 AKAQFERSLNRLQLDYVDLYLIHQPYG---------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFN 149
Cdd:cd19111 80 TEKSLEKSLENLKLPYVDLYLIHHPCGfvnkkdkgerelassDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 150 NVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAE----------GKNGLFQHPVLTAIGEKYGKSVGQVVLRWIY 219
Cdd:cd19111 160 KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSpgranqslwpDQPDLLEDPTVLAIAKELDKTPAQVLLRFVL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 447097196 220 QRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALDTATSAF 264
Cdd:cd19111 240 QRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKYF 284
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
4-258 |
6.07e-70 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 218.47 E-value: 6.07e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMtDAAECERAVIDAINSGYRLIDTAASYQNEIQVGN----ALKQSGIARNELFVTTKLWLQD 79
Cdd:cd19113 3 IKLNSGYKMPSVGFGCWKL-DNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEgvnrAIDEGLVKREELFLTSKLWNNF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQP-------------------------YGDVH--GAWRAMEELQQAGKIRAI 132
Cdd:cd19113 82 HDPKNVETALNKTLSDLKLDYVDLFLIHFPiafkfvpieekyppgfycgdgdnfvYEDVPilDTWKALEKLVDAGKIKSI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 133 GVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFA-----EGKNG-------LFQHPVLT 200
Cdd:cd19113 162 GVSNFPGALILDLLRGATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGpqsfvELNQGralntptLFEHDTIK 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 447097196 201 AIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19113 242 SIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLD 299
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
2-258 |
1.78e-68 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 214.59 E-value: 1.78e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 2 QKVKLNNGIEMPLLGFGVFQMTDAAeCERAVIDAINSGYRLIDTAASYQNEIQVGN----ALKQSGIARNELFVTTKLWL 77
Cdd:cd19115 3 PTVKLNSGYDMPLVGFGLWKVNNDT-CADQVYNAIKAGYRLFDGACDYGNEVEAGQgvarAIKEGIVKREDLFIVSKLWN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 78 QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP----YGD----------------------VHGAWRAMEELQQAGKIRA 131
Cdd:cd19115 82 TFHDGERVEPICRKQLADWGIDYFDLFLIHFPialkYVDpavryppgwfydgkkvefsnapIQETWTAMEKLVDKGLARS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 132 IGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPF------------AEGKNGLFQHPVL 199
Cdd:cd19115 162 IGVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFgpqsfleldlpgAKDTPPLFEHDVI 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 447097196 200 TAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19115 242 KSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALD 300
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
6-257 |
1.42e-67 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 211.50 E-value: 1.42e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 6 LNNGIEMPLLGFGVFQmTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQS-----GIARNELFVTTKLWLQDT 80
Cdd:cd19118 1 LNTGNKIPAIGLGTWQ-AEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELlkeepGVKREDLFITSKLWNNSH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 81 SYEGAKAQFERSLNRLQLDYVDLYLIH-----QPYGDVHG---------------------AWRAMEELQQAGKIRAIGV 134
Cdd:cd19118 80 RPEYVEPALDDTLKELGLDYLDLYLIHwpvafKPTGDLNPltavptnggevdldlsvslvdTWKAMVELKKTGKVKSIGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 135 SNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPF---AEGKNGLFQHPVLTAIGEKYGKSVG 211
Cdd:cd19118 160 SNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLgnnLAGLPLLVQHPEVKAIAAKLGKTPA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 447097196 212 QVVLRWIYQRGIVSLAKSVRKERMEENINilDFELSPEDMLQITAL 257
Cdd:cd19118 240 QVLIAWGIQRGHSVIPKSVTPSRIRSNFE--QVELSDDEFNAVTAL 283
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
4-258 |
7.48e-67 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 210.46 E-value: 7.48e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNALK---QSG-IARNELFVTTKLWLQD 79
Cdd:cd19155 4 VTFNNGEKMPVVGLGTWQSSPE-EIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKkwiDSGkVKREELFIVTKLPPGG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG-----------------------DVHGAWRAMEELQQAGKIRAIGVSN 136
Cdd:cd19155 83 NRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGslskeddsgkldptgehkqdyttDLLDIWKAMEAQVDQGLTRSIGLSN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 137 FHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAP--------FAEGKNG-------LFQHPVLTA 201
Cdd:cd19155 163 FNREQMARILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPlgspgaahFSPGTGSpsgsspdLLQDPVVKA 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 447097196 202 IGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19155 243 IAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLD 299
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
1-251 |
2.76e-66 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 208.15 E-value: 2.76e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKLNNGIEMPLLGFGVFQmTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQS---GIARNELFVTTKLWl 77
Cdd:cd19121 1 MTSFKLNTGASIPAVGLGTWQ-AKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAiagGVKREDLFVTTKLW- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 78 qDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP-------------------------YGDVHGaWRAMEELQQAGKIRAI 132
Cdd:cd19121 79 -STYHRRVELCLDRSLKSLGLDYVDLYLVHWPvllnpngnhdlfptlpdgsrdldwdWNHVDT-WKQMEKVLKTGKTKAI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 133 GVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQ 212
Cdd:cd19121 157 GVSNYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGSTGSPLISDEPVVEIAKKHNVGPGT 236
|
250 260 270
....*....|....*....|....*....|....*....
gi 447097196 213 VVLRWIYQRGIVSLAKSVRKERMEENINILDFElsPEDM 251
Cdd:cd19121 237 VLISYQVARGAVVLPKSVTPDRIKSNLEIIDLD--DEDM 273
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
9-259 |
5.04e-66 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 208.18 E-value: 5.04e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGVFQMtDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALK---QSGIA-RNELFVTTKLWLQDTSYEG 84
Cdd:cd19114 1 GDKMPLVGFGTAKI-KANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRkaiQEGLVkREDLFIVTKLWNNFHGKDH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 85 AKAQFERSLNRLQLDYVDLYLIHQP----YGD-----------------------VHGAWRAMEELQQAGKIRAIGVSNF 137
Cdd:cd19114 80 VREAFDRQLKDYGLDYIDLYLIHFPipaaYVDpaenypflwkdkelkkfpleqspMQECWREMEKLVDAGLVRNIGIANF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 138 HPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFA---------EGKN--GLFQHPVLTAIGEKY 206
Cdd:cd19114 160 NVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGnavytkvtkHLKHftNLLEHPVVKKLADKH 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 447097196 207 GKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALDT 259
Cdd:cd19114 240 KRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEA 292
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
2-258 |
2.87e-64 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 203.62 E-value: 2.87e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 2 QKVKLNNGIEMPLLGFGVF--QMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALkQSGIA-----RNELFVTTK 74
Cdd:cd19108 1 QRVKLNDGHFIPVLGFGTYapEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAI-RSKIAdgtvkREDIFYTSK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 75 LWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG----------DVHG-----------AWRAMEELQQAGKIRAIG 133
Cdd:cd19108 80 LWCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVAlkpgeelfpkDENGklifdtvdlcaTWEAMEKCKDAGLAKSIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 134 VSNFHpDRLADLIaFN----NVVPAVNQVEVNPFNQQLQAVPWMQSRGI-----------QPEAW----APFaegkngLF 194
Cdd:cd19108 160 VSNFN-RRQLEMI-LNkpglKYKPVCNQVECHPYLNQSKLLDFCKSKDIvlvaysalgsqRDKEWvdqnSPV------LL 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447097196 195 QHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19108 232 EDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLN 295
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
12-257 |
5.61e-64 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 201.04 E-value: 5.61e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 12 MPLLGFGVFQMTDAAeCERAVIDAINSGYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKAQFER 91
Cdd:cd19139 1 IPAFGLGTFRLKDDV-VIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLSKDKLLPSLEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 92 SLNRLQLDYVDLYLIH--QPYG--DVHGAWRAMEELQQAGKIRAIGVSNF---HPDRLADLIAFNNVvpAVNQVEVNPFN 164
Cdd:cd19139 80 SLEKLRTDYVDLTLIHwpSPNDevPVEEYIGALAEAKEQGLTRHIGVSNFtiaLLDEAIAVVGAGAI--ATNQIELSPYL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 165 QQLQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDF 244
Cdd:cd19139 158 QNRKLVAHCKQHGIHVTSYMTLAYGK--VLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDL 235
|
250
....*....|...
gi 447097196 245 ELSPEDMLQITAL 257
Cdd:cd19139 236 TLDADDMAAIAAL 248
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
9-254 |
4.64e-63 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 199.38 E-value: 4.64e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFG----VFQMTDAAECERAVID----AINSGYRLIDTAASYQN---EIQVGNALKqsGIARNELFVTTKLWL 77
Cdd:cd19072 1 GEEVPVLGLGtwgiGGGMSKDYSDDKKAIEalryAIELGINLIDTAEMYGGghaEELVGKAIK--GFDREDLFITTKVSP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 78 QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP--YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAF-NNVVPA 154
Cdd:cd19072 79 DHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPnpSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYlKKGPIV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 155 VNQVEVNPFNQ--QLQAVPWMQSRGIQPEAWAPFAEGK-NGLFQHPVLTAIGEKYGKSVGQVVLRW-IYQRGIVSLAKSV 230
Cdd:cd19072 159 ANQVEYNLFDReeESGLLPYCQKNGIAIIAYSPLEKGKlSNAKGSPLLDEIAKKYGKTPAQIALNWlISKPNVIAIPKAS 238
|
250 260
....*....|....*....|....
gi 447097196 231 RKERMEENINILDFELSPEDMLQI 254
Cdd:cd19072 239 NIEHLEENAGALGWELSEEDLQRL 262
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
9-254 |
5.50e-60 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 193.02 E-value: 5.50e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGVFQmTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNA----LKQSGIARNELFVTTKLWlqDTSYEG 84
Cdd:cd19107 1 GAKMPILGLGTWK-SPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAiqekIKEQVVKREDLFIVSKLW--CTFHEK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 85 A--KAQFERSLNRLQLDYVDLYLIHQPYGDVHG---------------------AWRAMEELQQAGKIRAIGVSNFHPDR 141
Cdd:cd19107 78 GlvKGACQKTLSDLKLDYLDLYLIHWPTGFKPGkelfpldesgnvipsdttfldTWEAMEELVDEGLVKAIGVSNFNHLQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 142 LADLIAFNNVV--PAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAE--------GKNGLFQHPVLTAIGEKYGKSVG 211
Cdd:cd19107 158 IERILNKPGLKykPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSpdrpwakpEDPSLLEDPKIKEIAAKHNKTTA 237
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 447097196 212 QVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19107 238 QVLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATI 280
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
7-253 |
1.63e-59 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 191.13 E-value: 1.63e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 7 NNGIEMPLLGFGVFqMTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQ----SGIARNELFVTTKLWLQDTSY 82
Cdd:cd19129 1 NGSGAIPALGFGTL-IPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEvfkaGKIRREDLFVTTKLWNTNHRP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 83 EGAKAQFERSLNRLQLDYVDLYLIHQPYG----------DVHGA------------WRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19129 80 ERVKPAFEASLKRLQLDYLDLYLIHTPFAfqpgdeqdprDANGNviyddgvtlldtWRAMERLVDEGRCKAIGLSDVSLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 141 RLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEG-KNGLFQHPVLTAIGEKYGKSVGQVVLRWIY 219
Cdd:cd19129 160 KLREIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGmEPKLLEDPVITAIARRVNKTPAQVLLAWAI 239
|
250 260 270
....*....|....*....|....*....|....*.
gi 447097196 220 QRGIVSLAKSVRKERMEENinildFELS--PEDMLQ 253
Cdd:cd19129 240 QRGTALLTTSKTPSRIREN-----FDIStlPEDAMR 270
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
2-254 |
2.72e-59 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 189.77 E-value: 2.72e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 2 QKVKLNNGIEMPLLGFGVFQM----TDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQSgiaRNELFVTTK 74
Cdd:cd19138 1 RTVTLPDGTKVPALGQGTWYMgedpAKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR---RDKVFLVSK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 75 LWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPyGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLADLIAF---N 149
Cdd:cd19138 78 VLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWR-GGVPLAetVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVpggG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 150 NVvpAVNQVEVNPFNQ--QLQAVPWMQSRGIQPEAWAPFAEG---KNGLFQHPVLTAIGEKYGKSVGQVVLRW-IYQRGI 223
Cdd:cd19138 157 NC--AANQVLYNLGSRgiEYDLLPWCREHGVPVMAYSPLAQGgllRRGLLENPTLKEIAARHGATPAQVALAWvLRDGNV 234
|
250 260 270
....*....|....*....|....*....|.
gi 447097196 224 VSLAKSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19138 235 IAIPKSGSPEHARENAAAADLELTEEDLAEL 265
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
12-258 |
4.49e-58 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 186.77 E-value: 4.49e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 12 MPLLGFGVFQMTDaaeceRAVIDAINS----GYRLIDTAASYQNEIQVGNALKQSGIARNELFVTTKLWLQDTSYEGAKA 87
Cdd:PRK11172 3 IPAFGLGTFRLKD-----QVVIDSVKTalelGYRAIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLAKDKLIP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 88 QFERSLNRLQLDYVDLYLIHQPY-GDVHGAWRAMEELQQA---GKIRAIGVSNFHPDRLADLIAfnnVVP----AVNQVE 159
Cdd:PRK11172 78 SLKESLQKLRTDYVDLTLIHWPSpNDEVSVEEFMQALLEAkkqGLTREIGISNFTIALMKQAIA---AVGaeniATNQIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 160 VNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKngLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENI 239
Cdd:PRK11172 155 LSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK--VLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNL 232
|
250
....*....|....*....
gi 447097196 240 NILDFELSPEDMLQITALD 258
Cdd:PRK11172 233 LAQDLQLDAEDMAAIAALD 251
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
5-257 |
5.83e-56 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 182.05 E-value: 5.83e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 5 KLNNGIEMPLLGFGVFQMTDA-AECERAVIDAINSGYRLIDTAASYQNEIQVGNALK-----QSGIARNELFVTTKLWLQ 78
Cdd:cd19122 2 TLNNGVKIPAVGFGTFANEGAkGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRdflkeNPSVKREDLFICTKVWNH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 79 DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYG-------------------------DVHGAWRAMEELQQAGKIRAIG 133
Cdd:cd19122 82 LHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAaekndqrspklgpdgkyvilkdlteNPEPTWRAMEEIYESGKAKAIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 134 VSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKN------GLFQHPVLTAIGEKYG 207
Cdd:cd19122 162 VSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQvpstgeRVSENPTLNEVAEKGG 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 447097196 208 KSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILdfELSPEDMLQITAL 257
Cdd:cd19122 242 YSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSI--ELSDEDFEAINQV 289
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
13-257 |
1.16e-55 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 180.80 E-value: 1.16e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 13 PLLGFGVFQMTDAaECERAVIDAINSGYRLIDTAASYQNEIQVGNAL----KQSGIARNELFVTTKLWLQDTSYEGAKAQ 88
Cdd:cd19128 2 PRLGFGTYKITES-ESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFseifKDGGVKREDLFITSKLWPTMHQPENVKEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 89 FERSLNRLQLDYVDLYLIHQPYGDVHGA---------------------WRAMEELQQAGKIRAIGVSNFHPDRLADLIA 147
Cdd:cd19128 81 LLITLQDLQLEYLDLFLIHWPLAFDMDTdgdprddnqiqslskkpledtWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 148 FNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAP----FAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQR-- 221
Cdd:cd19128 161 YCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPlggsYGDGNLTFLNDSELKALATKYNTTPPQVIIAWHLQKwp 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 447097196 222 GIVS-LAKSVRKERMEENINILDFELSPEDMLQITAL 257
Cdd:cd19128 241 KNYSvIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
9-258 |
1.40e-54 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 178.84 E-value: 1.40e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGVFQ---MTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQS----GIARNELFVTTKLWLQDTS 81
Cdd:cd19109 1 GNSIPIIGLGTYSepkTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKiaegKVKREDIFYCGKLWNTCHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 82 YEGAKAQFERSLNRLQLDYVDLYLIHQPYG---------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19109 81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAfkpgdeiyprdengkwlyhktNLCATWEALEACKDAGLVKSIGVSNFNRR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 141 RLaDLIaFNN----VVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNG---------LFQHPVLTAIGEKYG 207
Cdd:cd19109 161 QL-ELI-LNKpglkHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPiwvnvssppLLEDPLLNSIGKKYN 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 447097196 208 KSVGQVVLRWIYQRGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19109 239 KTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALN 289
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-257 |
5.33e-53 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 174.98 E-value: 5.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKL-NNGIEMPLLGFGVFQM------TDAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKqsGIARNELF 70
Cdd:COG0667 1 MEYRRLgRSGLKVSRLGLGTMTFggpwggVDEAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALK--GRPRDDVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 71 VTTKL--------WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:COG0667 79 IATKVgrrmgpgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTpiEETLGALDELVREGKIRYIGVSNYSAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 141 RLADL--IAFNNVVPAVNQVEVNPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-----------------KNGLFQHPV- 198
Cdd:COG0667 159 QLRRAlaIAEGLPPIVAVQNEYSLLDRSAEEelLPAARELGVGVLAYSPLAGGlltgkyrrgatfpegdrAATNFVQGYl 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447097196 199 ----------LTAIGEKYGKSVGQVVLRWIYQRGIVSL----AKSVrkERMEENINILDFELSPEDMLQITAL 257
Cdd:COG0667 239 ternlalvdaLRAIAAEHGVTPAQLALAWLLAQPGVTSvipgARSP--EQLEENLAAADLELSAEDLAALDAA 309
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
11-258 |
5.50e-53 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 174.76 E-value: 5.50e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 11 EMPLLGFGVFQMTdAAECERAVIDAINSGYRLIDTAASYQNEIQVGNAL----KQSGIARNELFVTTKLWLQDTSYEGAK 86
Cdd:cd19110 3 DIPAVGLGTWKAS-PGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIrekiKEGVVRREDLFIVSKLWCTCHKKSLVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 87 AQFERSLNRLQLDYVDLYLIHQPYG---------------------DVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADL 145
Cdd:cd19110 82 TACTRSLKALKLNYLDLYLIHWPMGfkpgepdlpldrsgmvipsdtDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLERL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 146 IAFNN--VVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNG--LFQHPVLTAIGEKYGKSVGQVVLRWIYQR 221
Cdd:cd19110 162 LNKPGlrVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGSCEGvdLIDDPVIQRIAKKHGKSPAQILIRFQIQR 241
|
250 260 270
....*....|....*....|....*....|....*..
gi 447097196 222 GIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:cd19110 242 NVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLD 278
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
4-241 |
2.85e-52 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 172.68 E-value: 2.85e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 4 VKLNNGIEMPLLGFGVFQ-MTDAAECERAVIDAINSGYRLIDTAASYQNEIQVGNALKQS----GIARNELFVTTKLWlq 78
Cdd:cd19119 4 FKLNTGASIPALGLGTASpHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAiddgSIKREELFITTKVW-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 79 DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPY---------------------------GDVHGAWRAMEELQQAGKIRA 131
Cdd:cd19119 82 PTFYDEVERSLDESLKALGLDYVDLLLVHWPVcfekdsddsgkpftpvnddgktryaasGDHITTYKQLEKIYLDGRAKA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 132 IGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVG 211
Cdd:cd19119 162 IGVSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAPNLKNPLVKKIAEKYNVSTG 241
|
250 260 270
....*....|....*....|....*....|
gi 447097196 212 QVVLRWIYQRGIVSLAKSVRKERMEENINI 241
Cdd:cd19119 242 DILISYHVRQGVIVLPKSLKPVRIVSNGKI 271
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
15-258 |
4.52e-52 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 171.73 E-value: 4.52e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQM------TDAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGIARNELFVTTKL------WLQD 79
Cdd:pfam00248 1 IGLGTWQLgggwgpISKEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDYPVKRDKVVIATKVpdgdgpWPSG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH--GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQ 157
Cdd:pfam00248 81 GSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPieETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 158 VEVNPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-----------------------KNGLFQH--PVLTAIGEKYGKSV 210
Cdd:pfam00248 161 VEYNLLRRRQEEelLEYCKKNGIPLIAYSPLGGGlltgkytrdpdkgpgerrrllkkGTPLNLEalEALEEIAKEHGVSP 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 447097196 211 GQVVLRWIYQ--RGIVSLAKSVRKERMEENINILDFELSPEDMLQITALD 258
Cdd:pfam00248 241 AQVALRWALSkpGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
15-254 |
1.03e-43 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 150.37 E-value: 1.03e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQMTDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKqsGIaRNELFVTTKLWLQ---------DTSY 82
Cdd:cd19084 14 IGGTWWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALK--GR-RDDVVIATKCGLRwdggkgvtkDLSP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVpaVNQVEV 160
Cdd:cd19084 91 ESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTpiEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGPIV--SLQPPY 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 161 NPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-------------------KNGLFQHP----------VLTAIGEKYGKS 209
Cdd:cd19084 169 SMLEREIEEelLPYCRENGIGVLPYGPLAQGlltgkykkeptfppddrrsRFPFFRGEnfeknleivdKLKEIAEKYGKS 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 447097196 210 VGQVVLRWIYQRGIVSL----AKSVrkERMEENINILDFELSPEDMLQI 254
Cdd:cd19084 249 LAQLAIAWTLAQPGVTSaivgAKNP--EQLEENAGALDWELTEEELKEI 295
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
15-256 |
2.47e-43 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 149.27 E-value: 2.47e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQM--------TDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQSgiaRNELFVTTKLWLQDTSYE 83
Cdd:cd19085 4 LGLGCWQFgggywwgdQDDEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKGR---RDDVVIATKVSPDNLTPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 84 GAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVpaVNQVEVN 161
Cdd:cd19085 81 DVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEetMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGRID--SNQLPYN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 162 PFNQQLQA--VPWMQSRGIQPEAWAPFAEG-----------------KNGLFQH-------------PVLTAIGEKYGKS 209
Cdd:cd19085 159 LLWRAIEYeiLPFCREHGIGVLAYSPLAQGlltgkfssaedfppgdaRTRLFRHfepgaeeetfealEKLKEIADELGVT 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 447097196 210 VGQVVLRWIYQR-GIVS-LAKSVRKERMEENINILDFELSPEDMLQITA 256
Cdd:cd19085 239 MAQLALAWVLQQpGVTSvIVGARNPEQLEENAAAVDLELSPSVLERLDE 287
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
11-251 |
5.51e-42 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 145.83 E-value: 5.51e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 11 EMPLLGFGVFQMTD----------AAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGiARNELFVTTKL-- 75
Cdd:cd19093 1 EVSPLGLGTWQWGDrlwwgygeygDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKELG-DRDEVVIATKFap 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 76 ----WLQDTSYEGAKAqferSLNRLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRL---ADL 145
Cdd:cd19093 80 lpwrLTRRSVVKALKA----SLERLGLDSIDLYQLHWPgpwYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLrraHKA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 146 IAFNNVVPAVNQVE---VNPFNQQLQAVPWMQSRGIQPEAWAPFA--------------EGKNGLFQHP----------- 197
Cdd:cd19093 156 LKERGVPLASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAqglltgkyspenppPGGRRRLFGRknlekvqplld 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 447097196 198 VLTAIGEKYGKSVGQVVLRWIYQRGIVSL--AKSVrkERMEENINILDFELSPEDM 251
Cdd:cd19093 236 ALEEIAEKYGKTPAQVALNWLIAKGVVPIpgAKNA--EQAEENAGALGWRLSEEEV 289
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
9-251 |
1.49e-41 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 143.87 E-value: 1.49e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGVFQM-----TDAAECERAV---IDAINSGYRLIDTAASY---QNEIQVGNALKQsgIARNELFVTTKLWL 77
Cdd:cd19137 1 GEKIPALGLGTWGIggfltPDYSRDEEMVellKTAIELGYTHIDTAEMYgggHTEELVGKAIKD--FPREDLFIVTKVWP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 78 QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAV 155
Cdd:cd19137 79 TNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIplEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQTPIVC 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 156 NQVEVNPFNQQLQ---AVPWMQSRGIQPEAWAPFAEGknGLFQHPVLTAIGEKYGKSVGQVVLRWIYQR-GIVSLAKSVR 231
Cdd:cd19137 159 NQVKYNLEDRDPErdgLLEYCQKNGITVVAYSPLRRG--LEKTNRTLEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGR 236
|
250 260
....*....|....*....|
gi 447097196 232 KERMEENINILDFELSPEDM 251
Cdd:cd19137 237 VEHLKENLKATEIKLSEEEM 256
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
15-239 |
4.03e-41 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 141.89 E-value: 4.03e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQM---TDAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGIaRNELFVTTKL---WLQDTSYEGA 85
Cdd:cd06660 3 LGLGTMTFggdGDEEEAFALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGRGN-RDDVVIATKGghpPGGDPSRSRL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 86 -----KAQFERSLNRLQLDYVDLYLIHQPygD----VHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIA----FNNVV 152
Cdd:cd06660 82 spehiRRDLEESLRRLGTDYIDLYYLHRD--DpstpVEETLEALNELVREGKIRYIGVSNWSAERLAEALAyakaHGLPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 153 PAVNQVEVNPFNQQL---QAVPWMQSRGIQPEAWAPFAEGknglfqhpvltaigekygksVGQVVLRWIYQRGIVS--LA 227
Cdd:cd06660 160 FAAVQPQYSLLDRSPmeeELLDWAEENGLPLLAYSPLARG--------------------PAQLALAWLLSQPFVTvpIV 219
|
250
....*....|..
gi 447097196 228 KSVRKERMEENI 239
Cdd:cd06660 220 GARSPEQLEENL 231
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-257 |
1.05e-37 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 136.49 E-value: 1.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKL-NNGIEMPLLGFGV--FQMTDAAECERaVID-AINSGYRLIDTAASY-QNEIQVGNALKQsgiARNELFVTTKL 75
Cdd:COG1453 1 MQYRRLgKTGLEVSVLGFGGmrLPRKDEEEAEA-LIRrAIDNGINYIDTARGYgDSEEFLGKALKG---PRDKVILATKL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 76 --WLQDtsYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH--------GAWRAMEELQQAGKIRAIGVSnFHpDRLADL 145
Cdd:COG1453 77 ppWVRD--PEDMRKDLEESLKRLQTDYIDLYLIHGLNTEEDlekvlkpgGALEALEKAKAEGKIRHIGFS-TH-GSLEVI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 146 IAfnnvvpAVN-------QVEVNPFNQQLQAvpwmQSRGIQpEAWA---------PFAEGKngLFQHP-VLTAIGEKyGK 208
Cdd:COG1453 153 KE------AIDtgdfdfvQLQYNYLDQDNQA----GEEALE-AAAEkgigviimkPLKGGR--LANPPeKLVELLCP-PL 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 447097196 209 SVGQVVLRWIYQRGIVSLAKS--VRKERMEENINILD-FE-LSPEDMLQITAL 257
Cdd:COG1453 219 SPAEWALRFLLSHPEVTTVLSgmSTPEQLDENLKTADnLEpLTEEELAILERL 271
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-178 |
3.16e-36 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 129.14 E-value: 3.16e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 3 KVKL-NNGIEMPLLGFG--VFQMTDAAECERAVIDAINSGYRLIDTAASYQN-EIQVGNALKQSgiaRNELFVTTKLWlq 78
Cdd:cd19100 1 YRRLgRTGLKVSRLGFGggPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKGR---RDKVFLATKTG-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 79 DTSYEGAKAQFERSLNRLQLDYVDLYLIH---------QPYGDvHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLI--- 146
Cdd:cd19100 76 ARDYEGAKRDLERSLKRLGTDYIDLYQLHavdteedldQVFGP-GGALEALLEAKEEGKIRFIGISGHSPEVLLRALetg 154
|
170 180 190
....*....|....*....|....*....|..
gi 447097196 147 AFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGI 178
Cdd:cd19100 155 EFDVVLFPINPAGDHIDSFREELLPLAREKGV 186
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
7-250 |
2.87e-34 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 125.36 E-value: 2.87e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 7 NNGIEMPLLGFGVFQMTD----AAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQSGIARNELFVTTK----- 74
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADwgesAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALNPGLREKIEIQTKcgirl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 75 ------LWLQ--DTSYEGAKAQFERSLNRLQLDYVDLYLIHQP-----YGDVHgawRAMEELQQAGKIRAIGVSNFHPDR 141
Cdd:cd19092 81 gddprpGRIKhyDTSKEHILASVEGSLKRLGTDYLDLLLLHRPdplmdPEEVA---EAFDELVKSGKVRYFGVSNFTPSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 142 LADLIAFNNVVPAVNQVEVNPFNQQLQA---VPWMQSRGIQPEAWAPFAEGKngLFQ---------HPVLTAIGEKYGKS 209
Cdd:cd19092 158 IELLQSYLDQPLVTNQIELSLLHTEAIDdgtLDYCQLLDITPMAWSPLGGGR--LFGgfderfqrlRAALEELAEEYGVT 235
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 447097196 210 VGQVVLRWIYQR--GIVSLAKSVRKERMEENINILDFELSPED 250
Cdd:cd19092 236 IEAIALAWLLRHpaRIQPILGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
15-239 |
2.34e-33 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 122.34 E-value: 2.34e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQ------MTDAAECERAVIDAINSGYRLIDTAASYQN-EIQVGNALkqSGIARNELFVTTKLW--------LQD 79
Cdd:cd19095 3 LGLGTSGigrvwgVPSEAEAARLLNTALDLGINLIDTAPAYGRsEERLGRAL--AGLRRDDLFIATKVGthgeggrdRKD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 TSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDrLADLIAfNNVVPAVnQ 157
Cdd:cd19095 81 FSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDEltGEVLETLEDLKAAGKVRYIGVSGDGEE-LEAAIA-SGVFDVV-Q 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 158 VEVNPFNQQLQAV-PWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKY---------GKSVGQVVLRWIYQRGIVS-- 225
Cdd:cd19095 158 LPYNVLDREEEELlPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYARrpefaaeigGATWAQAALRFVLSHPGVSsa 237
|
250
....*....|....
gi 447097196 226 LAKSVRKERMEENI 239
Cdd:cd19095 238 IVGTTNPEHLEENL 251
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
15-240 |
4.76e-32 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 118.35 E-value: 4.76e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQM-------TDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQSgiaRNELFVTTKL--------- 75
Cdd:cd19086 6 IGFGTWGLggdwwgdVDDAEAIRALRAALDLGINFFDTADVYGDghsERLLGKALKGR---RDKVVIATKFgnrfdggpe 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 76 WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVv 152
Cdd:cd19086 83 RPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPpdeVLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALRRGGI- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 153 pAVNQVEVNPFNQQ--LQAVPWMQSRGIQPEAWAPFAEGknglfqhpVLTaigekyGKsVGQVVLRWIYQRGIVSL---- 226
Cdd:cd19086 162 -DVVQVIYNLLDQRpeEELFPLAEEHGVGVIARVPLASG--------LLT------GK-LAQAALRFILSHPAVSTvipg 225
|
250
....*....|....
gi 447097196 227 AKSVrkERMEENIN 240
Cdd:cd19086 226 ARSP--EQVEENAA 237
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
2-254 |
4.17e-31 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 117.70 E-value: 4.17e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 2 QKVKL-NNGIEMPLLGFGVFQMTDA-----AECERAVID-AINSGYRLIDTAASYQ---NEIQVGNALKQsgiARNELFV 71
Cdd:cd19076 1 PTRKLgTQGLEVSALGLGCMGMSAFygpadEEESIATLHrALELGVTFLDTADMYGpgtNEELLGKALKD---RRDEVVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 72 TTKLWLQ----------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHP 139
Cdd:cd19076 78 ATKFGIVrdpgsgfrgvDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVpiEETVGAMAELVEEGKVRYIGLSEASA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 140 DrlaDLIAFNNVVP--AVnQVEVNPFNQQLQA--VPWMQSRGIQPEAWAPFAEG------------KNGLF--QHP---- 197
Cdd:cd19076 158 D---TIRRAHAVHPitAV-QSEYSLWTRDIEDevLPTCRELGIGFVAYSPLGRGfltgaikspedlPEDDFrrNNPrfqg 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 198 -----------VLTAIGEKYGKSVGQVVLRWIYQRG--IVSLAKSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19076 234 enfdknlklveKLEAIAAEKGCTPAQLALAWVLAQGddIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-135 |
5.80e-31 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 115.76 E-value: 5.80e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKL-NNGIEMPLLGFGVfqMTDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKqsGIARNELFVTTKLW 76
Cdd:cd19105 1 MPYRTLgKTGLKVSRLGFGG--GGLPRESPELLRRALDLGINYFDTAEGYGNgnsEEIIGEALK--GLRRDKVFLATKAS 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447097196 77 LQD--TSYEGAKAQFERSLNRLQLDYVDLYLIHQP----YGDVHGAW-RAMEELQQAGKIRAIGVS 135
Cdd:cd19105 77 PRLdkKDKAELLKSVEESLKRLQTDYIDIYQLHGVdtpeERLLNEELlEALEKLKKEGKVRFIGFS 142
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
3-257 |
1.44e-30 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 116.36 E-value: 1.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 3 KVKL-NNGIEMPLLGFG--------VFQMTDAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKqsGIARNELF 70
Cdd:cd19083 1 KVKLgKSDIDVNPIGLGtnavgghnLYPNLDEEEGKDLVREALDNGVNLLDTAFIYglgRSEELVGEVLK--EYNRNEVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 71 VTTKLWLQ--------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPD 140
Cdd:cd19083 79 IATKGAHKfggdgsvlNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETpkAEAVGALQELKDEGKIRAIGVSNFSLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 141 RLADLIAFNNVvpAVNQVEVNPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-------------------KNGLFQHPV- 198
Cdd:cd19083 159 QLKEANKDGYV--DVLQGEYNLLQREAEEdiLPYCVENNISFIPYFPLASGllagkytkdtkfpdndlrnDKPLFKGERf 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 199 ---------LTAIGEKYGKSVGQVVLRWIYQRGIVS--LAKSVRKERMEENINILDFELSPEDMLQITAL 257
Cdd:cd19083 237 senldkvdkLKSIADEKGVTVAHLALAWYLTRPAIDvvIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
23-257 |
2.24e-29 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 112.77 E-value: 2.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 23 TDAAECERAVIDAinsGYRLIDTAASY---QNEIQVGNALKQsgiARNELFVTTK---LW------LQDTSYEGAKAQFE 90
Cdd:cd19102 26 RDSIAAIRAALDL---GINWIDTAAVYglgHSEEVVGRALKG---LRDRPIVATKcglLWdeegriRRSLKPASIRAECE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 91 RSLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVvpAVNQV---------- 158
Cdd:cd19102 100 ASLRRLGVDVIDLYQIHWPDPDepIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHPI--ASLQPpysllrrgie 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 159 -EVNPF--NQQLQAVPW--MQS----RGIQPEAWAPFAEG----KNGLFQHP----------VLTAIGEKYGKSVGQVVL 215
Cdd:cd19102 178 aEILPFcaEHGIGVIVYspMQSglltGKMTPERVASLPADdwrrRSPFFQEPnlarnlalvdALRPIAERHGRTVAQLAI 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 447097196 216 RWIYQR-GIVS-LAKSVRKERMEENINILDFELSPEDMLQITAL 257
Cdd:cd19102 258 AWVLRRpEVTSaIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
7-254 |
1.51e-28 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 110.83 E-value: 1.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 7 NNGIEMPLLGFGVFQM--------TDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQSgiaRNELFVTTKL 75
Cdd:cd19149 6 KSGIEASVIGLGTWAIgggpwwggSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGR---RDKVVLATKC 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 76 WL-------------------QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGV 134
Cdd:cd19149 83 GLrwdreggsfffvrdgvtvyKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVEtpIEETMEALEELKRQGKIRAIGA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 135 SNFHPDRLADLIAFNNVvpAVNQVEVNPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-------------------KNGL 193
Cdd:cd19149 163 SNVSVEQIKEYVKAGQL--DIIQEKYSMLDRGIEKelLPYCKKNNIAFQAYSPLEQGlltgkitpdrefdagdarsGIPW 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447097196 194 FQ----HPVLTA------IGEKYGKSVGQVVLRWI-YQRGIVSLAKSVRK-ERMEENINILDFELSPEDMLQI 254
Cdd:cd19149 241 FSpenrEKVLALlekwkpLCEKYGCTLAQLVIAWTlAQPGITSALCGARKpEQAEENAKAGDIRLSAEDIATM 313
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
23-254 |
1.69e-28 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 110.47 E-value: 1.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 23 TDAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGIaRNELFVTTKLWLQ---------DTSYEGAKAQFE 90
Cdd:cd19148 22 TDEKEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKALKEYGK-RDRVVIATKVGLEwdeggevvrNSSPARIRKEVE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 91 RSLNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLAdliAFNNVVP-AVNQVEVNPFNQQL 167
Cdd:cd19148 101 DSLRRLQTDYIDLYQVHWPDPLVpiEETAEALKELLDEGKIRAIGVSNFSPEQME---TFRKVAPlHTVQPPYNLFEREI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 168 QA--VPWMQSRGIQPEAWAPFAEG-------------KNGL------FQHP----VLTAI-------GEKYGKSVGQVVL 215
Cdd:cd19148 178 EKdvLPYARKHNIVTLAYGALCRGllsgkmtkdtkfeGDDLrrtdpkFQEPrfsqYLAAVeeldklaQERYGKSVIHLAV 257
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 447097196 216 RWIYQRGIVSLA--KSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19148 258 RWLLDQPGVSIAlwGARKPEQLDAVDEVFGWSLNDEDMKEI 298
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-261 |
1.70e-28 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 110.78 E-value: 1.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKL-NNGIEMPLLGFGVfqMT--------------DAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQs 62
Cdd:cd19091 1 MEYRTLgRSGLKVSELALGT--MTfgggggffgawggvDQEEADRLVDIALDAGINFFDTADVYsegESEEILGKALKG- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 63 giARNELFVTTKLWLQ--------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAI 132
Cdd:cd19091 78 --RRDDVLIATKVRGRmgegpndvGLSRHHIIRAVEASLKRLGTDYIDLYQLHGfdALTPLEETLRALDDLVRQGKVRYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 133 GVSNFHPDRLADLIAF----NNVVPAVNQVEVNPFNQQL--QAVPWMQSRGIQPEAWAPFAEG----------------- 189
Cdd:cd19091 156 GVSNFSAWQIMKALGIserrGLARFVALQAYYSLLGRDLehELMPLALDQGVGLLVWSPLAGGllsgkyrrgqpapegsr 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 190 --KNGLFQHPV-----------LTAIGEKYGKSVGQVVLRWIYQR-GIVSLAKSVRK-ERMEENINILDFELSPEdmlQI 254
Cdd:cd19091 236 lrRTGFDFPPVdrergydvvdaLREIAKETGATPAQVALAWLLSRpTVSSVIIGARNeEQLEDNLGAAGLSLTPE---EI 312
|
....*..
gi 447097196 255 TALDTAT 261
Cdd:cd19091 313 ARLDKVS 319
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
13-243 |
5.25e-26 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 102.64 E-value: 5.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 13 PLLGFGV--FQMT-----DAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGiaRNELFVTTKL-WLQDTS 81
Cdd:cd19096 1 SVLGFGTmrLPESdddsiDEEKAIEMIRYAIDAGINYFDTAYGYgggKSEEILGEALKEGP--REKFYLATKLpPWSVKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 82 YEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-------GAWRAMEELQQAGKIRAIGVSnFH--PDRLADLIAFNNVv 152
Cdd:cd19096 79 AEDFRRILEESLKRLGVDYIDFYLLHGLNSPEWlekarkgGLLEFLEKAKKEGLIRHIGFS-FHdsPELLKEILDSYDF- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 153 pAVNQVEVNPFNQQLQAvpwmQSRGIQpEAWA---------PFAEGknGLFQHP-VLTAIGEKYGKSVGQVVLRWIYQRG 222
Cdd:cd19096 157 -DFVQLQYNYLDQENQA----GRPGIE-YAAKkgmgviimePLKGG--GLANNPpEALAILCGAPLSPAEWALRFLLSHP 228
|
250 260
....*....|....*....|...
gi 447097196 223 IVSLAKS--VRKERMEENINILD 243
Cdd:cd19096 229 EVTTVLSgmSTPEQLDENIAAAD 251
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
15-247 |
2.60e-25 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 101.14 E-value: 2.60e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQMT---------DAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQsgiARNELFVTTKL------- 75
Cdd:cd19088 4 LGYGAMRLTgpgiwgppaDREEAIAVLRRALELGVNFIDTADSYgpdVNERLIAEALHP---YPDDVVIATKGglvrtgp 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 76 --WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNV 151
Cdd:cd19088 81 gwWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRidPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 152 VpAVnQVEVNPFNQQLQAV-PWMQSRGIQPEAWAPFAeGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRG--IVSLAK 228
Cdd:cd19088 161 V-SV-QNRYNLANRDDEGVlDYCEAAGIAFIPWFPLG-GGDLAQPGGLLAEVAARLGATPAQVALAWLLARSpvMLPIPG 237
|
250
....*....|....*....
gi 447097196 229 SVRKERMEENINILDFELS 247
Cdd:cd19088 238 TSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
7-255 |
5.59e-25 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 101.14 E-value: 5.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 7 NNGIEMPLLGFGVfqMTDAAECER----AVIDA-INSGYRLIDTAASY----------QNEIQVGNALKQSGiARNELFV 71
Cdd:cd19081 4 RTGLSVSPLCLGT--MVFGWTADEetsfALLDAfVDAGGNFIDTADVYsawvpgnaggESETIIGRWLKSRG-KRDRVVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 72 TTKL-WLQDTSYEGA-----KAQFERSLNRLQLDYVDLYLIHQPYGDVHGA--WRAMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:cd19081 81 ATKVgFPMGPNGPGLsrkhiRRAVEASLRRLQTDYIDLYQAHWDDPATPLEetLGALNDLIRQGKVRYIGASNYSAWRLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 144 D---------LIAFNNVVPAVNQVEVNPFNQQLQAVpwMQSRGIQPEAWAPFAEG------------------------- 189
Cdd:cd19081 161 EalelsrqhgLPRYVSLQPEYNLVDRESFEGELLPL--CREEGIGVIPYSPLAGGfltgkyrseadlpgstrrgeaakry 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 190 --KNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQR-GIVSLAKSVRK-ERMEENINILDFELSPEDMLQIT 255
Cdd:cd19081 239 lnERGLRILDALDEVAAEHGATPAQVALAWLLARpGVTAPIAGARTvEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
15-149 |
1.10e-24 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 99.94 E-value: 1.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQMTDAAECER-----AVID-AINSGYRLIDTAASYQN-EIQVGNALKqsGIARNELFVTTKL-----WLQDTSY 82
Cdd:cd19090 3 LGLGTAGLGGVFGGVDddeavATIRaALDLGINYIDTAPAYGDsEERLGLALA--ELPREPLVLSTKVgrlpeDTADYSA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447097196 83 EGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH-------GAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFN 149
Cdd:cd19090 81 DRVRRSVEESLERLGRDRIDLLMIHDPERVPWvdilapgGALEALLELKEEGLIKHIGLGGGPPDLLRRAIETG 154
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
24-249 |
6.83e-24 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 98.05 E-value: 6.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 24 DAAECERAvidAINSGYRLIDTAASY---QNEIQVGNALKqsGIARNELFVTTKL-W-LQDTSYE---GAK---AQFERS 92
Cdd:cd19074 23 DAKACVRK---AYDLGINFFDTADVYaagQAEEVLGKALK--GWPRESYVISTKVfWpTGPGPNDrglSRKhifESIHAS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 93 LNRLQLDYVDLYLIHQPYGDV--HGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIA----FNNVVPAVNQVEVNPFNQQ 166
Cdd:cd19074 98 LKRLQLDYVDIYYCHRYDPETplEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDlarqFGLIPPVVEQPQYNMLWRE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 167 LQA--VPWMQSRGIQPEAWAPFAEG--------------------------KNGLFQHPV------LTAIGEKYGKSVGQ 212
Cdd:cd19074 178 IEEevIPLCEKNGIGLVVWSPLAQGlltgkyrdgipppsrsratdednrdkKRRLLTDENlekvkkLKPIADELGLTLAQ 257
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 447097196 213 VVLRWIYQRGIVSlakSV-----RKERMEENINILDFELSPE 249
Cdd:cd19074 258 LALAWCLRNPAVS---SAiigasRPEQLEENVKASGVKLSPE 296
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-249 |
2.11e-23 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 96.47 E-value: 2.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKL-NNGIEMPLLGFG------VFQMTDAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKqsGIARNELF 70
Cdd:cd19163 1 MKYRKLgKTGLKVSKLGFGasplggVFGPVDEEEAIRTVHEALDSGINYIDTAPWYgqgRSETVLGKALK--GIPRDSYY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 71 VTTK------LWLQ--DTSYEGAKAQFERSLNRLQLDYVDLYLIH----QPYGD--VHGAWRAMEELQQAGKIRAIGVSN 136
Cdd:cd19163 79 LATKvgryglDPDKmfDFSAERITKSVEESLKRLGLDYIDIIQVHdiefAPSLDqiLNETLPALQKLKEEGKVRFIGITG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 137 FhpdrlaDLIAFNNVVPAV-NQVEV-------NPFNQQL-QAVPWMQSRGIQPEAWAPFAEG---KNGLFQ-HPVLTAIG 203
Cdd:cd19163 159 Y------PLDVLKEVLERSpVKIDTvlsychyTLNDTSLlELLPFFKEKGVGVINASPLSMGlltERGPPDwHPASPEIK 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 447097196 204 E----------KYGKSVGQVVLRW-IYQRGIVS-LAKSVRKERMEENINILDFELSPE 249
Cdd:cd19163 233 EacakaaayckSRGVDISKLALQFaLSNPDIATtLVGTASPENLRKNLEAAEEPLDAH 290
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
1-254 |
4.73e-23 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 96.36 E-value: 4.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 1 MQKVKL-NNGIEMPLLGFG-----VFQMTDAAECER-AVID-AINSGYRLIDTAASYQ-NEIQVGNALKQSGIARNELFV 71
Cdd:cd19144 1 IPTRTLgRNGPSVPALGFGamglsAFYGPPKPDEERfAVLDaAFELGCTFWDTADIYGdSEELIGRWFKQNPGKREKIFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 72 TTK-----------LWLqDTSYEGAKAQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFH 138
Cdd:cd19144 81 ATKfgieknvetgeYSV-DGSPEYVKKACETSLKRLGVDYIDLYYQHRvdGKTPIEKTVAAMAELVQEGKIKHIGLSECS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 139 PDRLADLIAFNNVVpAVnQVEVNPFNQQLQAVPW--MQS---RGIQPEAWAP---------------FAEG----KNGLF 194
Cdd:cd19144 160 AETLRRAHAVHPIA-AV-QIEYSPFSLDIERPEIgvLDTcreLGVAIVAYSPlgrgfltgairspddFEEGdfrrMAPRF 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447097196 195 QHP----------VLTAIGEKYGKSVGQVVLRWIYQRG--IVSLAKSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19144 238 QAEnfpknlelvdKIKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKLKRLEENLGALKVKLTEEEEKEI 309
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
15-239 |
1.04e-22 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 94.54 E-value: 1.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVF----QMTDAAECERAVIDAinsGYRLIDTAASYQN-------EIQVGNALKQSGIaRNELFVTTK-----LWLQ 78
Cdd:cd19082 5 LGTADFgtriDEEEAFALLDAFVEL---GGNFIDTARVYGDwvergasERVIGEWLKSRGN-RDKVVIATKgghpdLEDM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 79 DTSYEGAK---AQFERSLNRLQLDYVDLYLIH-----QPYGDVHGAwraMEELQQAGKIRAIGVSNFHPDRLADLIAF-- 148
Cdd:cd19082 81 SRSRLSPEdirADLEESLERLGTDYIDLYFLHrddpsVPVGEIVDT---LNELVRAGKIRAFGASNWSTERIAEANAYak 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 149 -NNVVP-AVNQV-----EVNPFN-------------------QQLQAVPWM-QSRG-----IQPEAWAPFAEGKngLFQH 196
Cdd:cd19082 158 aHGLPGfAASSPqwslaRPNEPPwpgptlvamdeemrawheeNQLPVFAYSsQARGffskrAAGGAEDDSELRR--VYYS 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 447097196 197 PV-------LTAIGEKYGKSVGQVVLRWIYQRG--IVSLAKSVRKERMEENI 239
Cdd:cd19082 236 EEnferlerAKELAEEKGVSPTQIALAYVLNQPfpTVPIIGPRTPEQLRDSL 287
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-143 |
5.90e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 93.15 E-value: 5.90e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQM----TDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQS----GIARNELFVTTK--------- 74
Cdd:cd19099 6 LGLGTYRGdsddETDEEYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELiekgGIKRDEVVIVTKagyipgdgd 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 75 ------LWLQ-------DTSYEGA-----------KAQFERSLNRLQLDYVDLYLIHQP------------YGDVHGAWR 118
Cdd:cd19099 86 eplrplKYLEeklgrglIDVADSAglrhcispaylEDQIERSLKRLGLDTIDLYLLHNPeeqllelgeeefYDRLEEAFE 165
|
170 180
....*....|....*....|....*
gi 447097196 119 AMEELQQAGKIRAIGVSNFHPDRLA 143
Cdd:cd19099 166 ALEEAVAEGKIRYYGISTWDGFRAP 190
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
9-254 |
1.18e-21 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 91.91 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGVFQMT-------DAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQsgiARNELFVTTKLWLQ 78
Cdd:cd19078 1 GLEVSAIGLGCMGMShgygpppDKEEMIELIRKAVELGITFFDTAEVYgpyTNEELVGEALKP---FRDQVVIATKFGFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 79 -----------DTSYEGAKAQFERSLNRLQLDYVDLYLIHQ-----PYGDVHGawrAMEELQQAGKIRAIGVSNFHPD-- 140
Cdd:cd19078 78 idggkpgplglDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRvdpnvPIEEVAG---TMKELIKEGKIRHWGLSEAGVEti 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 141 RLAdliafNNVVP--AVnQVEVNPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-------KNGLFQH-------P----- 197
Cdd:cd19078 155 RRA-----HAVCPvtAV-QSEYSMMWREPEKevLPTLEELGIGFVPFSPLGKGfltgkidENTKFDEgddraslPrftpe 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447097196 198 ----------VLTAIGEKYGKSVGQVVLRWIYQRG--IVSLAKSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19078 229 aleanqalvdLLKEFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIELTPEELREI 297
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
22-179 |
1.32e-21 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 91.05 E-value: 1.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 22 MTDAAECERAVIDAINSGYRLIDTAASYqneiqvGNALK---QSGIARNELFVTTKL----WLQDTSYEGAKAQFERSLN 94
Cdd:cd19097 22 KPSEKEAKKILEYALKAGINTLDTAPAY------GDSEKvlgKFLKRLDKFKIITKLpplkEDKKEDEAAIEASVEASLK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 95 RLQLDYVDLYLIHQP---YGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNvvPAVNQVEVNPFNQQLQAVP 171
Cdd:cd19097 96 RLKVDSLDGLLLHNPddlLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALESFK--IDIIQLPFNILDQRFLKSG 173
|
170
....*....|.
gi 447097196 172 W---MQSRGIQ 179
Cdd:cd19097 174 LlakLKKKGIE 184
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-165 |
8.97e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 87.32 E-value: 8.97e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFG------VFQMTDAAECERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQsgiARNELFVTTKLWLQD 79
Cdd:cd19104 9 GLKVSELTFGgggiggLMGRTTREEQIAAVRRALDLGINFFDTAPSYgdgKSEENLGRALKG---LPAGPYITTKVRLDP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 TSYEGAKAQFER----SLNRLQLDYVDLYLIHQ-------PYGDVH----------GAWRAMEELQQAGKIRAIGVSNF- 137
Cdd:cd19104 86 DDLGDIGGQIERsvekSLKRLKRDSVDLLQLHNrigderdKPVGGTlsttdvlglgGVADAFERLRSEGKIRFIGITGLg 165
|
170 180
....*....|....*....|....*...
gi 447097196 138 HPDRLADLIAFNnvVPAVNQVEVNPFNQ 165
Cdd:cd19104 166 NPPAIRELLDSG--KFDAVQVYYNLLNP 191
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
22-258 |
1.26e-19 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 86.50 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 22 MTDAAECeRAVIDA-INSGYRLIDTAASYQN---EIQVGNALKQSgiaRNELFVTTKLWL----QDTSYEG--AKA---Q 88
Cdd:cd19080 27 GADREEA-RAMFDAyVEAGGNFIDTANNYTNgtsERLLGEFIAGN---RDRIVLATKYTMnrrpGDPNAGGnhRKNlrrS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 89 FERSLNRLQLDYVDLYLIHQPYG--DVHGAWRAMEELQQAGKIRAIGVSNFHPDRL--ADLIA-FNNVVPAVN-QVEVNP 162
Cdd:cd19080 103 VEASLRRLQTDYIDLLYVHAWDFttPVEEVMRALDDLVRAGKVLYVGISDTPAWVVarANTLAeLRGWSPFVAlQIEYSL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 163 FNQQLQA--VPWMQSRGIQPEAWAPFAEGK-------------------NGLFQH---------PVLTAIGEKYGKSVGQ 212
Cdd:cd19080 183 LERTPERelLPMARALGLGVTPWSPLGGGLltgkyqrgeegrageakgvTVGFGKlternwaivDVVAAVAEELGRSAAQ 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 447097196 213 VVLRWIYQR-GIVSLAKSVRK-ERMEENINILDFELSPEdmlQITALD 258
Cdd:cd19080 263 VALAWVRQKpGVVIPIIGARTlEQLKDNLGALDLTLSPE---QLARLD 307
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
3-254 |
1.60e-19 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 86.33 E-value: 1.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 3 KVKL-NNGIEMPLLGFGVFQMT---DAAECERAVID----AINSGYRLIDTAASY---QNEIQVGNALKqsGIARNELFV 71
Cdd:cd19145 2 RVKLgSQGLEVSAQGLGCMGLSgdyGAPKPEEEGIAlihhAFNSGVTFLDTSDIYgpnTNEVLLGKALK--DGPREKVQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 72 TTKLWLQDTSYEG---------AKAQFERSLNRLQLDYVDLYLIHQ-----PYGDVHGawrAMEELQQAGKIRAIGVSNF 137
Cdd:cd19145 80 ATKFGIHEIGGSGvevrgdpayVRAACEASLKRLDVDYIDLYYQHRidttvPIEITMG---ELKKLVEEGKIKYIGLSEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 138 HPD--RLADLIafnNVVPAVnQVEVNPFNQQL--QAVPWMQSRGIQPEAWAPFAEG------------KNGLF--QHP-- 197
Cdd:cd19145 157 SADtiRRAHAV---HPITAV-QLEWSLWTRDIeeEIIPTCRELGIGIVPYSPLGRGffagkakleellENSDVrkSHPrf 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447097196 198 -------------VLTAIGEKYGKSVGQVVLRWIYQRG--IVSLAKSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19145 233 qgenleknkvlyeRVEALAKKKGCTPAQLALAWVLHQGedVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
23-137 |
4.98e-19 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 84.93 E-value: 4.98e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 23 TDAAEcERAVID-AINSGYRLIDTAASYQN---EIQVGNALKQSgiaRNELFVTTK--------LWLQDTSYEGAKAQFE 90
Cdd:cd19087 27 TDEET-SFAIMDrALDAGINFFDTADVYGGgrsEEIIGRWIAGR---RDDIVLATKvfgpmgddPNDRGLSRRHIRRAVE 102
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 447097196 91 RSLNRLQLDYVDLYLIHQPYGDVHG--AWRAMEELQQAGKIRAIGVSNF 137
Cdd:cd19087 103 ASLRRLQTDYIDLYQMHHFDRDTPLeeTLRALDDLVRQGKIRYIGVSNF 151
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
35-251 |
5.37e-19 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 84.94 E-value: 5.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 35 AINSGYRLIDTAASYQN----EIqVGNALKqSGIARNELFVTTKLWLQ---DTSYEGAK-----AQFERSLNRLQLDYVD 102
Cdd:cd19079 44 ALDLGINFFDTANVYSGgaseEI-LGRALK-EFAPRDEVVIATKVYFPmgdGPNGRGLSrkhimAEVDASLKRLGTDYID 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 103 LYLIHQpygdvhgaW----------RAMEELQQAGKIRAIGVSNFHPDRLADLIA---------FNNVVPAVNQV----- 158
Cdd:cd19079 122 LYQIHR--------WdyetpieetlEALHDVVKSGKVRYIGASSMYAWQFAKALHlaekngwtkFVSMQNHYNLLyreee 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 159 -EVNPFNQQ--LQAVPWmqS---RGIQPEAWAPFAEGKNGLFQ-------------HPVLTAIGE---KYGKSVGQVVLR 216
Cdd:cd19079 194 rEMIPLCEEegIGVIPW--SplaRGRLARPWGDTTERRRSTTDtaklkydyfteadKEIVDRVEEvakERGVSMAQVALA 271
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 447097196 217 WIYQRG-----IVSLAKsvrKERMEENINILDFELSPEDM 251
Cdd:cd19079 272 WLLSKPgvtapIVGATK---LEHLEDAVAALDIKLSEEEI 308
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
8-189 |
1.19e-18 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 84.05 E-value: 1.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFG---VFQMTDAAECERAVID-AINSGYRLIDTAASYQN---EIQVGNALKQSGIARNELFVTTKLWLQDT 80
Cdd:cd19142 9 SGLRVSNVGLGtwsTFSTAISEEQAEEIVTlAYENGINYFDTSDAFTSgqaETELGRILKKKGWKRSSYIVSTKIYWSYG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 81 SYEGAKAQ------FERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLI----AF 148
Cdd:cd19142 89 SEERGLSRkhiiesVRASLRRLQLDYIDIVIIHKadPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVEIMEAFsiarQF 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 447097196 149 NNVVPAVNQVEVNPFNQ---QLQAVPWMQSRGIQPEAWAPFAEG 189
Cdd:cd19142 169 NCPTPICEQSEYHMFCRekmELYMPELYNKVGVGLITWSPLSLG 212
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-243 |
2.73e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 82.76 E-value: 2.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 15 LGFGVFQMTDAAECERAVIDA-INSGYRLIDTAASY----------QNEIQVGNALKQSGiARNELFVTTKL-------W 76
Cdd:cd19752 5 LGTMYFGTRTDEETSFAILDRyVAAGGNFLDTANNYafwteggvggESERLIGRWLKDRG-NRDDVVIATKVgagprdpD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 77 LQDTSYEGA-----KAQFERSLNRLQLDYVDLYLIH--QPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRL--ADLIA 147
Cdd:cd19752 84 GGPESPEGLsaetiEQEIDKSLRRLGTDYIDLYYAHvdDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLerARQIA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 148 FNNVVPA-------------------VNQVEVNP-------FNQQLQAVPWM-QSRGIQPEAWAPFAEGknglFQHP--- 197
Cdd:cd19752 164 RQQGWAEfsaiqqrhsylrprpgadfGVQRIVTDelldyasSRPDLTLLAYSpLLSGAYTRPDRPLPEQ----YDGPdsd 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 447097196 198 ----VLTAIGEKYGKSVGQVVLRWIYQR--GIVSLAKSVRKERMEENINILD 243
Cdd:cd19752 240 arlaVLEEVAGELGATPNQVVLAWLLHRtpAIIPLLGASTVEQLEENLAALD 291
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-257 |
1.47e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 80.84 E-value: 1.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 30 RAVID-AINSGYRLIDTAASY---QNEIQVGNALKQsgIARNELFVTTKLWLQ--DTSYEGAKAQFERSLNRLQLDYVDL 103
Cdd:cd19103 35 KAVFDkAMAAGLNLWDTAAVYgmgASEKILGEFLKR--YPREDYIISTKFTPQiaGQSADPVADMLEGSLARLGTDYIDI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 104 YLIHQPyGDVHGAWRAMEELQQAGKIRAIGVSNFHPD--RLADLIAFNNVVP--AVNqvevNPFN------QQLQAVPWM 173
Cdd:cd19103 113 YWIHNP-ADVERWTPELIPLLKSGKVKHVGVSNHNLAeiKRANEILAKAGVSlsAVQ----NHYSllyrssEEAGILDYC 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 174 QSRGIQPEAWA---------------PFAEGK------NGLFQH-----PVLTAIGEKYGKSVGQVVLRWIYQRGIVSLA 227
Cdd:cd19103 188 KENGITFFAYMvleqgalsgkydtkhPLPEGSgraetyNPLLPQleeltAVMAEIGAKHGASIAQVAIAWAIAKGTTPII 267
|
250 260 270
....*....|....*....|....*....|
gi 447097196 228 KSVRKERMEENINILDFELSPEDMLQITAL 257
Cdd:cd19103 268 GVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
13-135 |
1.52e-17 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 80.48 E-value: 1.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 13 PLLGFGVFQMTDAAECER----AVID-AINSGYRLIDTAASY---QNEIQVGNALKqsGIARNELFVTTKL--------- 75
Cdd:cd19162 1 PRLGLGAASLGNLARAGEdeaaATLDaAWDAGIRYFDTAPLYglgLSERRLGAALA--RHPRAEYVVSTKVgrllepgaa 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447097196 76 -------WLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVH----GAWRAMEELQQAGKIRAIGVS 135
Cdd:cd19162 79 grpagadRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDRHLLqaltDAFPALEELRAEGVVGAIGVG 149
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
24-256 |
1.61e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 80.72 E-value: 1.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 24 DAAECERAVIDAINSGYRLIDTAASYQN-EIQVG---NALKQSGIARNELFVTTKL----WLQDTSYEGAKAQFERSLNR 95
Cdd:cd19101 21 DEDAAVRAMAAYVDAGLTTFDCADIYGPaEELIGefrKRLRRERDAADDVQIHTKWvpdpGELTMTRAYVEAAIDRSLKR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 96 LQLDYVDLYLIH-QPYGD---VHGAwRAMEELQQAGKIRAIGVSNFHPDRLADLIafNNVVPAV-NQVEVNPFNQ--QLQ 168
Cdd:cd19101 101 LGVDRLDLVQFHwWDYSDpgyLDAA-KHLAELQEEGKIRHLGLTNFDTERLREIL--DAGVPIVsNQVQYSLLDRrpENG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 169 AVPWMQSRGIQ-------------------PEAWAPFAE--------------GKNGLFQH--PVLTAIGEKYGKSVGQV 213
Cdd:cd19101 178 MAALCEDHGIKllaygtlaggllsekylgvPEPTGPALEtrslqkyklmidewGGWDLFQEllRTLKAIADKHGVSIANV 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 447097196 214 VLRWIYQR-GIVSLAKSVR-KERMEENINILDFELSPEDMLQITA 256
Cdd:cd19101 258 AVRWVLDQpGVAGVIVGARnSEHIDDNVRAFSFRLDDEDRAAIDA 302
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
13-249 |
6.29e-17 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 79.19 E-value: 6.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 13 PLLGFG------VFQMTDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKqsGIARNELFVTTKL-WL----- 77
Cdd:cd19152 1 PKLGFGtaplgnLYEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALR--ELGREDYVISTKVgRLlvplq 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 78 -------------------QDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP----YGDVH---------GAWRAMEELQQ 125
Cdd:cd19152 79 eveptfepgfwnplpfdavFDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPdedlAGAESdehfaqaikGAFRALEELRE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 126 AGKIRAIGV-SNFHP--DRLADLIAFNNVVPA-----VNQVEVNPFNQQLQAvpwmqsRGIQPEAWAPFAEGknglfqhp 197
Cdd:cd19152 159 EGVIKAIGLgVNDWEviLRILEEADLDWVMLAgrytlLDHSAARELLPECEK------RGVKVVNAGPFNSG-------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 198 vLTAIGEKYGKSVGQVVLRWIYQRGI----------VSLA-------------KSV-----RKERMEENINILDFELSPE 249
Cdd:cd19152 225 -FLAGGDNFDYYEYGPAPPELIARRDriealceqhgVSLAaaalqfalappavASVapgasSPERVEENVALLATEIPAA 303
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
16-260 |
1.05e-15 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 75.67 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 16 GFGVFQMTDAAECERAVIDAINS-GYRLIDTAASYQN---EIQVGNAlkqsGIARNELFVTTKL--WLQDT-SYEGAKAQ 88
Cdd:cd19075 9 TFGSQGRFTTAEAAAELLDAFLErGHTEIDTARVYPDgtsEELLGEL----GLGERGFKIDTKAnpGVGGGlSPENVRKQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 89 FERSLNRLQLDYVDLYLIHQPygD----VHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAF---NN-VVPAVNQVEV 160
Cdd:cd19075 85 LETSLKRLKVDKVDVFYLHAP--DrstpLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEIckeNGwVLPTVYQGMY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 161 NPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-------------KNGLFQHP---------------------VLTAIGE 204
Cdd:cd19075 163 NAITRQVETelFPCLRKLGIRFYAYSPLAGGfltgkykysedkaGGGRFDPNnalgklyrdrywkpsyfealeKVEEAAE 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447097196 205 KYGKSVGQVVLRWIYQR---------GIVSLAKSVrkERMEENINILDFELSPEDMLQitALDTA 260
Cdd:cd19075 243 KEGISLAEAALRWLYHHsaldgekgdGVILGASSL--EQLEENLAALEKGPLPEEVVK--AIDEA 303
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
18-146 |
9.14e-15 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 72.57 E-value: 9.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 18 GVFQMTDAA-ECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQSGIARNELFVTTKL-----WLQDTSYEGAKAQ 88
Cdd:cd19153 24 GVYGDGLEQdEAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAALQVPRSSYTVATKVgryrdSEFDYSAERVRAS 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447097196 89 FERSLNRLQLDYVDLYLIH-----QPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLI 146
Cdd:cd19153 104 VATSLERLHTTYLDVVYLHdiefvDYDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRAT 166
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
7-250 |
2.09e-14 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 71.90 E-value: 2.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 7 NNGIEMPLLGFGVFQ----MTDAAECERAVIDAINSGYRLIDTAASY-----QNEIQVGNALKQSGIA-RNELFVTTKlw 76
Cdd:cd19089 6 RSGLHLPAISLGLWHnfgdYTSPEEARELLRTAFDLGITHFDLANNYgpppgSAEENFGRILKRDLRPyRDELVISTK-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 77 lqdTSYE---------GAK----AQFERSLNRLQLDYVDLYLIHQPYGDVhgawrAMEELQQA-------GKIRAIGVSN 136
Cdd:cd19089 84 ---AGYGmwpgpygdgGSRkyllASLDQSLKRMGLDYVDIFYHHRYDPDT-----PLEETMTAladavrsGKALYVGISN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 137 FHPDRLADLIAFNN---VVPAVNQVEVNPFNQQLQA--VPWMQSRGIQPEAWAPFAEG-----------------KNGLF 194
Cdd:cd19089 156 YPGAKARRAIALLRelgVPLIIHQPRYSLLDRWAEDglLEVLEEAGIGFIAFSPLAQGlltdkylngippdsrraAESKF 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447097196 195 QHPV------------LTAIGEKYGKSVGQVVLRWIYQR-GIVSLAKSV-RKERMEENINILD-FELSPED 250
Cdd:cd19089 236 LTEEaltpekleqlrkLNKIAAKRGQSLAQLALSWVLRDpRVTSVLIGAsSPSQLEDNVAALKnLDFSEEE 306
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
17-145 |
4.62e-13 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 67.69 E-value: 4.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 17 FGVFQMTDAAEC--ERAVIDAINSGYRLIDTAASYQN-EIQVGNALK--QSGIARNELFVTTK-----LWLQDTSYEGAK 86
Cdd:cd19164 23 FSYQYTTDPESIppVDIVRRALELGIRAFDTSPYYGPsEIILGRALKalRDEFPRDTYFIITKvgrygPDDFDYSPEWIR 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447097196 87 AQFERSLNRLQLDYVDLYLIHQ----PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADL 145
Cdd:cd19164 103 ASVERSLRRLHTDYLDLVYLHDvefvADEEVLEALKELFKLKDEGKIRNVGISGYPLPVLLRL 165
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
8-254 |
5.94e-13 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 68.09 E-value: 5.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGV---FQMTDAAECERAVI-DAINSGYRLIDTAASY-----QNEIQVGNALKQSGIA-RNELFVTTK--- 74
Cdd:PRK09912 21 SGLRLPALSLGLwhnFGHVNALESQRAILrKAFDLGITHFDLANNYgpppgSAEENFGRLLREDFAAyRDELIISTKagy 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 75 -LWLQDTSYEGAK----AQFERSLNRLQLDYVDLYLIHQ-----PYGDVHGawrAMEELQQAGKIRAIGVSNFHPDR--- 141
Cdd:PRK09912 101 dMWPGPYGSGGSRkyllASLDQSLKRMGLEYVDIFYSHRvdentPMEETAS---ALAHAVQSGKALYVGISSYSPERtqk 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 142 LADLIAFNNVVPAVNQVEVNPFNQ---QLQAVPWMQSRGIQPEAWAPFAEG------KNGL---------------FQHP 197
Cdd:PRK09912 178 MVELLREWKIPLLIHQPSYNLLNRwvdKSGLLDTLQNNGVGCIAFTPLAQGlltgkyLNGIpqdsrmhregnkvrgLTPK 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447097196 198 VLTA-----------IGEKYGKSVGQVVLRWIYQRGIVS--LAKSVRKERMEENINIL-DFELSPEDMLQI 254
Cdd:PRK09912 258 MLTEanlnslrllneMAQQRGQSMAQMALSWLLKDERVTsvLIGASRAEQLEENVQALnNLTFSTEELAQI 328
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
8-254 |
7.61e-13 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 67.26 E-value: 7.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGVFQMT---------DAAECERAVIDAinsGYRLIDTAASY------QNEIQVGNALKQSGIARNELFVT 72
Cdd:cd19077 1 NGKLVGPIGLGLMGLTwrpnptpdeEAFETMKAALDA---GSNLWNGGEFYgppdphANLKLLARFFRKYPEYADKVVLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 73 TK-----LWLQ-DTSYEGAKAQFERSLNRL-QLDYVDLYlihqpygdvhGAWR------------AMEELQQAGKIRAIG 133
Cdd:cd19077 78 VKggldpDTLRpDGSPEAVRKSIENILRALgGTKKIDIF----------EPARvdpnvpieetikALKELVKEGKIRGIG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 134 VSnfHPDrlADLIA-FNNVVP-AVNQVEVNPFNQQLQ---AVPWMQSRGIQPEAWAPFAEG------------KNGLF-Q 195
Cdd:cd19077 148 LS--EVS--AETIRrAHAVHPiAAVEVEYSLFSREIEengVLETCAELGIPIIAYSPLGRGlltgriksladiPEGDFrR 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447097196 196 HP----------------VLTAIGEKYGKSVGQVVLRWI---YQRGIVSLAKSVRKERMEENINILDFELSPEDMLQI 254
Cdd:cd19077 224 HLdrfngenfeknlklvdALQELAEKKGCTPAQLALAWIlaqSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEI 301
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
8-189 |
1.32e-12 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 66.99 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGVF-----QMTDAAeCERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGIARNELFVTTKLwlqd 79
Cdd:cd19159 9 SGLRVSCLGLGTWvtfggQISDEV-AERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKKGWRRSSLVITTKL---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 tsYEGAKAQFER-------------SLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19159 84 --YWGGKAETERglsrkhiieglkgSLQRLQLEYVDVVFANRPDSNtpMEEIVRAMTHVINQGMAMYWGTSRWSAMEIME 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 447097196 145 LIA----FNNVVPAVNQVEVNPFNQ---QLQAVPWMQSRGIQPEAWAPFAEG 189
Cdd:cd19159 162 AYSvarqFNMIPPVCEQAEYHLFQRekvEVQLPELYHKIGVGAMTWSPLACG 213
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
35-257 |
3.15e-12 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 65.66 E-value: 3.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 35 AINSGYRLIDTAASY----------QNEIQVGNALKQSGiARNELFVTTKL--------WLQDT----SYEGAKAQFERS 92
Cdd:cd19094 27 AFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKKG-NRDKVVLATKVagpgegitWPRGGgtrlDRENIREAVEGS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 93 LNRLQLDYVDLYLIHQP-----------YGDVHGAW---------RAMEELQQAGKIRAIGVSN--------FHpdRLAD 144
Cdd:cd19094 106 LKRLGTDYIDLYQLHWPdrytplfgggyYTEPSEEEdsvsfeeqlEALGELVKAGKIRHIGLSNetpwgvmkFL--ELAE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 145 LiafNNVVPAVN-QVEVNPFNQQL----------QAVPWMqsrgiqpeAWAPFAEG-------------KNG---LFQHP 197
Cdd:cd19094 184 Q---LGLPRIVSiQNPYSLLNRNFeeglaeachrENVGLL--------AYSPLAGGvltgkyldgaarpEGGrlnLFPGY 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447097196 198 --------------VLTAIGEKYGKSVGQVVLRWIYQRGIVSlakSV-----RKERMEENINILDFELSPEDMLQITAL 257
Cdd:cd19094 253 maryrspqaleavaEYVKLARKHGLSPAQLALAWVRSRPFVT---STiigatTLEQLKENIDAFDVPLSDELLAEIDAV 328
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
9-189 |
1.25e-11 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 64.01 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGVF-----QMTDAAeCERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGIARNELFVTTKLwlqdt 80
Cdd:cd19141 9 GLRVSCLGLGTWvtfgsQISDEV-AEELVTLAYENGINLFDTAEVYaagKAEIVLGKILKKKGWRRSSYVITTKI----- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 81 sYEGAKAQFER-------------SLNRLQLDYVDLYLIHQPygDVHgawRAMEELQQA-------GKIRAIGVSNFHPD 140
Cdd:cd19141 83 -FWGGKAETERglsrkhiieglkaSLERLQLEYVDIVFANRP--DPN---TPMEEIVRAfthvinqGMAMYWGTSRWSAM 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 447097196 141 RLADLIA----FNNVVPAVNQVEVNPFNQ---QLQAVPWMQSRGIQPEAWAPFAEG 189
Cdd:cd19141 157 EIMEAYSvarqFNLIPPIVEQAEYHLFQRekvEMQLPELFHKIGVGAMTWSPLACG 212
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
10-257 |
1.88e-11 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 63.72 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 10 IEMPLLGFGVF---QMTDAAECERAVIDAINSGYRLIDTAASYQ----------NEIQVGNALKQSGiARNELFVTTKLW 76
Cdd:PRK10625 11 LEVSTLGLGTMtfgEQNSEADAHAQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKRG-SREKLIIASKVS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 77 ------------LQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQP------YGDVHGAW-------------RAMEELQQ 125
Cdd:PRK10625 90 gpsrnndkgirpNQALDRKNIREALHDSLKRLQTDYLDLYQVHWPqrptncFGKLGYSWtdsapavslletlDALAEQQR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 126 AGKIRAIGVSNFHP------DRLAD------LIAFNNVVPAVNQvevnPFNQQLQAVPwmQSRGIQPEAWAPFAEG---- 189
Cdd:PRK10625 170 AGKIRYIGVSNETAfgvmryLHLAEkhdlprIVTIQNPYSLLNR----SFEVGLAEVS--QYEGVELLAYSCLAFGtltg 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 190 -----------KNGLF-----------QHPV--LTAIGEKYGKSVGQVVLRWIYQRGIVS--LAKSVRKERMEENINILD 243
Cdd:PRK10625 244 kylngakpagaRNTLFsrftrysgeqtQKAVaaYVDIAKRHGLDPAQMALAFVRRQPFVAstLLGATTMEQLKTNIESLH 323
|
330
....*....|....
gi 447097196 244 FELSPEDMLQITAL 257
Cdd:PRK10625 324 LTLSEEVLAEIEAV 337
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
7-135 |
2.92e-11 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 62.87 E-value: 2.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 7 NNGIEMPLLGFG------VFQMTDAAECERAVIDAINSGYRLIDTAASYQN---EIQVGNALKQSGIARNELFVTTKLWL 77
Cdd:PLN02587 6 STGLKVSSVGFGasplgsVFGPVSEEDAIASVREAFRLGINFFDTSPYYGGtlsEKVLGKALKALGIPREKYVVSTKCGR 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447097196 78 Q----DTSYEGAKAQFERSLNRLQLDYVDLYLIHQ-PYGD----VHGAWRAMEELQQAGKIRAIGVS 135
Cdd:PLN02587 86 YgegfDFSAERVTKSVDESLARLQLDYVDILHCHDiEFGSldqiVNETIPALQKLKESGKVRFIGIT 152
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
8-257 |
4.20e-11 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 62.31 E-value: 4.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGVF-----QMTDAAeCERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGIARNELFVTTKLwlqd 79
Cdd:cd19160 11 SGLRVSCLGLGTWvtfgsQISDET-AEDLLTVAYEHGVNLFDTAEVYaagKAERTLGNILKSKGWRRSSYVVTTKI---- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 tsYEGAKAQFER-------------SLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19160 86 --YWGGQAETERglsrkhiieglrgSLDRLQLEYVDIVFANRsdPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAMEIME 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 145 LIA----FNNVVPAVNQVEVNPFNQ---QLQAVPWMQSRGIQPEAWAPFA------------------------------ 187
Cdd:cd19160 164 AYSvarqFNLIPPVCEQAEYHLFQRekvEMQLPELYHKIGVGSVTWSPLAcglitgkydgrvpdtcraavkgyqwlkekv 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447097196 188 ---EGKNGLFQHPVLTAIGEKYGKSVGQVVLRW-IYQRGIVSLAKSVRK-ERMEENINILDF--ELSPEDMLQITAL 257
Cdd:cd19160 244 qseEGKKQQAKVKELHPIADRLGCTVAQLAIAWcLRSEGVSSVLLGVSSaEQLIENLGSIQVlsQLTPQTVMEIDAL 320
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
25-254 |
4.54e-11 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 62.23 E-value: 4.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 25 AAECERAvidAINSGYRLIDTAASYQN---EIQVGNALKQSGIARNELFVTTKL-W------LQDTS------YEGAKAq 88
Cdd:cd19143 33 AKECMKA---AYDAGVNFFDNAEVYANgqsEEIMGQAIKELGWPRSDYVVSTKIfWggggppPNDRGlsrkhiVEGTKA- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 89 ferSLNRLQLDYVDLYLIHQPygDVHG----AWRAMEELQQAGKIRAIGVSNF------HPDRLAD---LIAfnnvvPAV 155
Cdd:cd19143 109 ---SLKRLQLDYVDLVFCHRP--DPATpieeTVRAMNDLIDQGKAFYWGTSEWsaqqieEAHEIADrlgLIP-----PVM 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 156 NQVEVNPFNQQ---LQAVPWMQSRGIQPEAWAPFAEG---------------------------KNGLFQHPV-----LT 200
Cdd:cd19143 179 EQPQYNLFHRErveVEYAPLYEKYGLGTTTWSPLASGlltgkynngipegsrlalpgyewlkdrKEELGQEKIekvrkLK 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447097196 201 AIGEKYGKSVGQVVLRWIYQRGIVSlakSV-----RKERMEENINILDF--ELSPEDMLQI 254
Cdd:cd19143 259 PIAEELGCSLAQLAIAWCLKNPNVS---TVitgatKVEQLEENLKALEVlpKLTPEVMEKI 316
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
7-251 |
1.91e-10 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 60.49 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 7 NNGIEMPLLGFGV---FQMTDAAECERAVI-DAINSGYRLIDTAASY-----QNEIQVGNALKQSGIA-RNELFVTTK-- 74
Cdd:cd19151 7 RSGLKLPAISLGLwhnFGDVDRYENSRAMLrRAFDLGITHFDLANNYgpppgSAEENFGRILKEDLKPyRDELIISTKag 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 75 --LWlqDTSYE--GAK----AQFERSLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19151 87 ytMW--PGPYGdwGSKkyliASLDQSLKRMGLDYVDIFYHHRPDPEtpLEETMGALDQIVRQGKALYVGISNYPPEEARE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 145 LIAFNNV--VPA-VNQVEVNPFN----QQLQAVpwMQSRGIQPEAWAPFAEG-----------------KNGLFQHP--- 197
Cdd:cd19151 165 AAAILKDlgTPClIHQPKYSMFNrwveEGLLDV--LEEEGIGCIAFSPLAQGlltdrylngipedsraaKGSSFLKPeqi 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447097196 198 ---------VLTAIGEKYGKSVGQVVLRWIYQRGIVS--LAKSVRKERMEENINILD-FELSPEDM 251
Cdd:cd19151 243 teeklakvrRLNEIAQARGQKLAQMALAWVLRNKRVTsvLIGASKPSQIEDAVGALDnREFSEEEL 308
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
30-133 |
2.94e-10 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 59.65 E-value: 2.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 30 RAVID-AINSGYRLIDTAASYQN---EIQVGNALKQSGiaRNELFVTTKL-----------------WLQ--------DT 80
Cdd:cd19161 23 DATLDaAWDSGIRYFDTAPMYGHglaEHRLGDFLREKP--RDEFVLSTKVgrllkparegsvpdpngFVDplpfeivyDY 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447097196 81 SYEGAKAQFERSLNRLQLDYVDLYLIHQ--PY--GDVH----------GAWRAMEELQQAGKIRAIG 133
Cdd:cd19161 101 SYDGIMRSFEDSLQRLGLNRIDILYVHDigVYthGDRKerhhfaqlmsGGFKALEELKKAGVIKAFG 167
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
8-239 |
3.80e-10 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 59.71 E-value: 3.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 8 NGIEMPLLGFGVF-----QMTDAAeCERAVIDAINSGYRLIDTAASY---QNEIQVGNALKQSGIARNELFVTTKLwlqd 79
Cdd:cd19158 9 SGLRVSCLGLGTWvtfggQITDEM-AEHLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKKKGWRRSSLVITTKI---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 80 tsYEGAKAQFER-------------SLNRLQLDYVDLYLIHQPYGD--VHGAWRAMEELQQAGKIRAIGVSNFHPDRLAD 144
Cdd:cd19158 84 --FWGGKAETERglsrkhiieglkaSLERLQLEYVDVVFANRPDPNtpMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 145 LIA----FNNVVPAVNQVEVNPFNQ---QLQAVPWMQSRGIQPEAWAPFA------------------------------ 187
Cdd:cd19158 162 AYSvarqFNLIPPICEQAEYHMFQRekvEVQLPELFHKIGVGAMTWSPLAcgivsgkydsgippysraslkgyqwlkdki 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 447097196 188 ---EGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVS--LAKSVRKERMEENI 239
Cdd:cd19158 242 lseEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSsvLLGASNAEQLMENI 298
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
9-251 |
3.01e-08 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 53.61 E-value: 3.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 9 GIEMPLLGFGV---FQMTDAAECERAVI-DAINSGYRLIDTAASY-----QNEIQVGNALKQSGIA-RNELFVTTK---- 74
Cdd:cd19150 9 GLKLPALSLGLwhnFGDDTPLETQRAILrTAFDLGITHFDLANNYgpppgSAEENFGRILREDFAGyRDELIISTKagyd 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 75 LWLQDTSYEGAK----AQFERSLNRLQLDYVDLYLIHQ--PYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDR---LADL 145
Cdd:cd19150 89 MWPGPYGEWGSRkyllASLDQSLKRMGLDYVDIFYSHRfdPDTPLEETMGALDHAVRSGKALYVGISSYSPERtreAAAI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 146 IAFNNVVPAVNQVEVNPFNQQLQA---VPWMQSRGIQPEAWAPFAEG-----------------KNGLFQHPVLT----- 200
Cdd:cd19150 169 LRELGTPLLIHQPSYNMLNRWVEEsglLDTLQELGVGCIAFTPLAQGlltdkylngipegsrasKERSLSPKMLTeanln 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 201 ------AIGEKYGKSVGQVVLRWIYQRGIVS--LAKSVRKERMEENINILD-FELSPEDM 251
Cdd:cd19150 249 siralnEIAQKRGQSLAQMALAWVLRDGRVTsaLIGASRPEQLEENVGALDnLTFSADEL 308
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
12-261 |
4.92e-08 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 53.05 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 12 MPLLGFGVF---QMTDAAeceRAVI-DAINSGYRLIDTAASYQNeiQVGNALKQSGIA--RNELFVTTKL---------W 76
Cdd:PRK10376 25 MQLAGPGVFgppKDRDAA---IAVLrEAVALGVNHIDTSDFYGP--HVTNQLIREALHpyPDDLTIVTKVgarrgedgsW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 77 LQDTSYEGAKAQFERSLNRLQ---LDYVDLYLIhqpyGDVHG--------AWRAMEELQQAGKIRAIGVSNFHPDRLADL 145
Cdd:PRK10376 100 LPAFSPAELRRAVHDNLRNLGldvLDVVNLRLM----GDGHGpaegsieePLTVLAELQRQGLVRHIGLSNVTPTQVAEA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 146 IAFNNVVPAVNQVEV-----NPFNQQLQAvpwmqsRGIqpeAWAPFAE--GKNGLfQHPVLTAIGEKYGKSVGQVVLRWI 218
Cdd:PRK10376 176 RKIAEIVCVQNHYNLahradDALIDALAR------DGI---AYVPFFPlgGFTPL-QSSTLSDVAASLGATPMQVALAWL 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 447097196 219 YQR--------GIVSLAksvrkeRMEENINILDFELSPEDMLQITALDTAT 261
Cdd:PRK10376 246 LQRspnillipGTSSVA------HLRENLAAAELVLSEEVLAELDGIAREA 290
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
38-258 |
1.45e-06 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 48.67 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 38 SGYRLIDTAASYQN---EIQVGNALKQSGIaRNELFVTTKLWLQDTSYE---GAKAQF------------ERSLNRLQLD 99
Cdd:cd19147 46 AGGNFIDTANNYQDeqsETWIGEWMKSRKN-RDQIVIATKFTTDYKAYEvgkGKAVNYcgnhkrslhvsvRDSLRKLQTD 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 100 YVDLYLIH--QPYGDVHGAWRAMEELQQAGKIRAIGVSnfhpDRLADLIAFNN--------VVPAVNQVEVNPFNQQLQ- 168
Cdd:cd19147 125 WIDILYVHwwDYTTSIEEVMDSLHILVQQGKVLYLGVS----DTPAWVVSAANyyatahgkTPFSVYQGRWNVLNRDFEr 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 169 -----------AV-PW-------------MQSRGIQPEAWAPFAEGKNglfQHPVLTAIGEKYGK--------SVGQVVL 215
Cdd:cd19147 201 diipmarhfgmALaPWdvlgggkfqskkaVEERKKNGEGLRSFVGGTE---QTPEEVKISEALEKvaeehgteSVTAIAL 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 447097196 216 RWiyqrgIVSLAKSV------RK-ERMEENINILDFELSPEdmlQITALD 258
Cdd:cd19147 278 AY-----VRSKAPNVfplvggRKiEHLKDNIEALSIKLTPE---EIEYLE 319
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
31-256 |
3.65e-06 |
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Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 47.42 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 31 AVIDAI-NSGYRLIDTAASYQ---NEIQVGNALKQSGIaRNELFVTTKLWL---------QDTSYEGAKAQ-----FERS 92
Cdd:cd19146 39 KLLDAFyEQGGNFIDTANNYQgeeSERWVGEWMASRGN-RDEMVLATKYTTgyrrggpikIKSNYQGNHAKslrlsVEAS 117
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 93 LNRLQLDYVDLYLIHqpYGD----VHGAWRAMEELQQAGKIRAIGVSnfhpDRLADLIA-------FNNVVP-AVNQVEV 160
Cdd:cd19146 118 LKKLQTSYIDILYVH--WWDyttsIPELMQSLNHLVAAGKVLYLGVS----DTPAWVVSkanayarAHGLTQfVVYQGHW 191
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447097196 161 NPFNQQLQ--AVPWMQSRGIqpeAWAPFAEGKNGLFQHP-------------------------VLTAIGEKYGKSVGQV 213
Cdd:cd19146 192 SAAFRDFErdILPMCEAEGM---ALAPWGVLGQGQFRTEeefkrrgrsgrkggpqtekerkvseKLEKVAEEKGTAITSV 268
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250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 447097196 214 VLRWIYQRG-----IVslakSVRK-ERMEENINILDFELSPEDMLQITA 256
Cdd:cd19146 269 ALAYVMHKApyvfpIV----GGRKvEHLKGNIEALGISLSDEEIQEIED 313
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