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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Bacillus]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 3.12e-41

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 134.14  E-value: 3.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244   1 MQLDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKNGDTTR 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447098244  81 MQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVL 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErlaaLPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 3.12e-41

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 134.14  E-value: 3.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244   1 MQLDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKNGDTTR 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447098244  81 MQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVL 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErlaaLPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-107 5.69e-35

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 117.23  E-value: 5.69e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244     3 LDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKNGDT-TRM 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEF 80

                           90       100
                   ....*....|....*....|....*.
gi 447098244    82 QQFIQSYPSASFCYRVTGSLCYIVKI 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-140 1.07e-19

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 80.19  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244   3 LDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKNGDTTRMQ 82
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447098244  83 QF---IQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVLSEVSLT 140
Cdd:PRK11169  92 QFnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGEtllrLPGVNDTRTYVVMEEVKQT 156
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
4-44 1.28e-14

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 63.54  E-value: 1.28e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 447098244    4 DRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLE 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 3.77e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.29  E-value: 3.77e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 447098244   4 DRVDRKILNELYnDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKY 52
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 3-51 1.58e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.95  E-value: 1.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 447098244    3 LDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQK 51
Cdd:TIGR01884 141 LSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 3.12e-41

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 134.14  E-value: 3.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244   1 MQLDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKNGDTTR 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447098244  81 MQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVL 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErlaaLPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-107 5.69e-35

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 117.23  E-value: 5.69e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244     3 LDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKNGDT-TRM 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEF 80

                           90       100
                   ....*....|....*....|....*.
gi 447098244    82 QQFIQSYPSASFCYRVTGSLCYIVKI 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-140 1.07e-19

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 80.19  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244   3 LDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKNGDTTRMQ 82
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447098244  83 QF---IQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVLSEVSLT 140
Cdd:PRK11169  92 QFnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGEtllrLPGVNDTRTYVVMEEVKQT 156
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
4-44 1.28e-14

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 63.54  E-value: 1.28e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 447098244    4 DRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLE 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
5-49 4.49e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 62.07  E-value: 4.49e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 447098244    5 RVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVI 49
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-130 1.20e-12

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 61.26  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447098244   1 MQLDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDIDYKKAGLVLDCILEITLKN-GDTT 79
Cdd:PRK11179   5 YQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSaKDYP 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447098244  80 RMQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELE-------EFINDVSSYATTVS 130
Cdd:PRK11179  85 SALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQhvlinkiQTIDEIQSTETLIS 142
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 69-136 1.08e-09

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 51.76  E-value: 1.08e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447098244   69 LEITLKNG-DTTRMQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVLSE 136
Cdd:pfam01037   1 VEVKLEPGhALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREklrsLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 3.77e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.29  E-value: 3.77e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 447098244   4 DRVDRKILNELYnDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKY 52
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 2-51 2.34e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.18  E-value: 2.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 447098244    2 QLDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQK 51
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVER 51
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 9-52 1.50e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 34.83  E-value: 1.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 447098244    9 KILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKY 52
Cdd:pfam01047   7 HILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERS 50
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 3-51 1.58e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.95  E-value: 1.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 447098244    3 LDRVDRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQK 51
Cdd:TIGR01884 141 LSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
9-57 1.64e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.03  E-value: 1.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 447098244     9 KILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQKYTIDID 57
Cdd:smart00347  14 LVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPED 62
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
7-51 1.81e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.78  E-value: 1.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 447098244   7 DRKILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQK 51
Cdd:COG3398   99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVER 143
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-51 4.27e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.33  E-value: 4.27e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 447098244  10 ILNELYNDSRLSMRELAKRVNLSAPSTAERVRKLESEGVIQK 51
Cdd:COG1846   43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVER 84
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
8-50 5.19e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 34.55  E-value: 5.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 447098244   8 RKILNELYNDSrLSMRELAKRVNLSAPSTAERVRKLESEGVIQ 50
Cdd:COG4189   22 LRILRLLAEEP-LNVNELAEALGLPKSTVSYHIRKLEEAGLIR 63
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
8-52 6.88e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 34.24  E-value: 6.88e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 447098244   8 RKILNELYNDSRlSMRELAKRVNLSAPSTAERVRKLESEGVIQKY 52
Cdd:COG1777   20 RRILALLSEEPA-YVSELARELGVSRQAVYKHLRKLEEAGLVESY 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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