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Conserved domains on  [gi|447099583|ref|WP_001176839|]
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MULTISPECIES: HilA family transcriptional regulator EilA [Escherichia]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
1-552 0e+00

HilA/EilA family virulence transcriptional regulator;


:

Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 958.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583   1 MQLQHGKNTTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYA 80
Cdd:PRK12370   2 MHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  81 LRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKSTTTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPA 160
Cdd:PRK12370  82 LRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLPV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 161 SVTNEASDFSTIHQFINKTGPEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP 240
Cdd:PRK12370 162 TITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCIP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 241 NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCLAECHISLALLGLSEQKQAIT 320
Cdd:PRK12370 242 GLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAMI 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 321 TAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIAL 400
Cdd:PRK12370 322 KAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKL 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 401 EPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL 480
Cdd:PRK12370 402 DPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNLL 481

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447099583 481 YTKFLIYGASIKNDIMKLLANISTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSNVLLHDPRLLSVK 552
Cdd:PRK12370 482 YAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR 553
 
Name Accession Description Interval E-value
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
1-552 0e+00

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 958.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583   1 MQLQHGKNTTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYA 80
Cdd:PRK12370   2 MHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  81 LRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKSTTTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPA 160
Cdd:PRK12370  82 LRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLPV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 161 SVTNEASDFSTIHQFINKTGPEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP 240
Cdd:PRK12370 162 TITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCIP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 241 NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCLAECHISLALLGLSEQKQAIT 320
Cdd:PRK12370 242 GLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAMI 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 321 TAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIAL 400
Cdd:PRK12370 322 KAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKL 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 401 EPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL 480
Cdd:PRK12370 402 DPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNLL 481

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447099583 481 YTKFLIYGASIKNDIMKLLANISTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSNVLLHDPRLLSVK 552
Cdd:PRK12370 482 YAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR 553
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
11-114 3.17e-29

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 111.15  E-value: 3.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  11 QQYIFGDFVL-KNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYALRKLLHEN- 88
Cdd:COG3710    1 MRYRFGDFRLdPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNSLTQAISRLRKALGDDg 80

                         90       100
                 ....*....|....*....|....*.
gi 447099583  89 KQCKYIETVYGRGYRFTVPIVIVTDN 114
Cdd:COG3710   81 LEPRLIRTVPRRGYRLVAPVEVEAPE 106
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 26-104 1.58e-18

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 80.60  E-value: 1.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  26 LLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWS-ASVASDESLTRCIYALRKLLHENKQCKYIETVYGRGYRF 104
Cdd:cd00383   10 VTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGyDYEVDDRTVDVHISRLRKKLEDDPEPRLIKTVRGVGYRL 89
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 30-104 5.24e-17

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 75.67  E-value: 5.24e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447099583    30 NKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDE-SLTRCIYALRKLLHENKQCKYIETVYGRGYRF 104
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDnTLDVHISRLRKKLEDDGDPRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
30-104 2.19e-16

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 74.09  E-value: 2.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447099583   30 NKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDE-SLTRCIYALRKLLHENKQC-KYIETVYGRGYRF 104
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDnTVDVHISRLRKKLEDDPRDpRLIKTVRGVGYRL 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 246-470 7.24e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.39  E-value: 7.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  246 SINTQQMPS--LDSAVMYMNGrmemyrytpeSLKRALVIFRDCVSTQPQNTLPYCCLAechisLALLGLSEQKQAITTav 323
Cdd:TIGR02917 289 KSAPEYLPAllLAGASEYQLG----------NLEQAYQYLNQILKYAPNSHQARRLLA-----SIQLRLGRVDEAIAT-- 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  324 tsIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPN 403
Cdd:TIGR02917 352 --LSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPE 429

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447099583  404 kMGISILKLIILYYTS-PLDNAISFALNLnSQNTCNNPIITSILAMFMALKGHNDKAKSLL---LKLEPEH 470
Cdd:TIGR02917 430 -LGRADLLLILSYLRSgQFDKALAAAKKL-EKKQPDNASLHNLLGAIYLGKGDLAKAREAFekaLSIEPDF 498
 
Name Accession Description Interval E-value
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
1-552 0e+00

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 958.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583   1 MQLQHGKNTTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYA 80
Cdd:PRK12370   2 MHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  81 LRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKSTTTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPA 160
Cdd:PRK12370  82 LRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLPV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 161 SVTNEASDFSTIHQFINKTGPEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP 240
Cdd:PRK12370 162 TITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCIP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 241 NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCLAECHISLALLGLSEQKQAIT 320
Cdd:PRK12370 242 GLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAMI 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 321 TAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIAL 400
Cdd:PRK12370 322 KAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKL 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 401 EPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL 480
Cdd:PRK12370 402 DPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNLL 481

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447099583 481 YTKFLIYGASIKNDIMKLLANISTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSNVLLHDPRLLSVK 552
Cdd:PRK12370 482 YAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR 553
PRK11906 PRK11906
HilA family transcriptional regulator YgeH;
7-448 1.98e-54

HilA family transcriptional regulator YgeH;


Pssm-ID: 183373 [Multi-domain]  Cd Length: 458  Bit Score: 191.04  E-value: 1.98e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583   7 KNTTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYALRKLLH 86
Cdd:PRK11906   4 ENKFSYHFLEGLTLTEDGILTQGNEQVYIPQKELGVLIVLLESAGHVVLKDMIIESVWKNIIVSDESLTRCIYSLRCIFE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  87 ENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKSTTTLAVFPFRTE-GSINVLKLHYELVQGLSKYAFCGLDILPASVTNE 165
Cdd:PRK11906  84 KIGYDRCIETIYRKGYRFSGQVFKTKINEDNTSDYSIAIFPFTTSlNTLDPLILNQELVQIISNKKIDGLYTYPMAATNF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 166 ASDFSTIHQFINKTGPEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIdfnPDNPLSVLLSQVINILIEKIPNINfK 245
Cdd:PRK11906 164 CNDHISQNSFLSRFKPDYFVTGRINQNNAVNTLYIELIDAKNLFLIASNHL---PVDELHNTSQFIIDNILQTVHKPE-R 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 246 SI----NTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIF---RDCVSTQPQNTLPYCCLAECHISLALLGLSEQKQA 318
Cdd:PRK11906 240 SVrlakQDQGYKNHYLSDEMLAGKKELYDFTPESIYRAMTIFdrlQNKSDIQTLKTECYCLLAECHMSLALHGKSELELA 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 319 ITTAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSI 398
Cdd:PRK11906 320 AQKALELLDYVSDITTVDGKILAIMGLITGLSGQAKVSHILFEQAKIHSTDIASLYYYRALVHFHNEKIEEARICIDKSL 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 447099583 399 ALEPNKMGISILKLII-LYYTSPLDNAISFALNLNSQNTcNNPIITSILAM 448
Cdd:PRK11906 400 QLEPRRRKAVVIKECVdMYVPNPLKNNIKLYYKETESES-HRVIIDNILKL 449
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
11-114 3.17e-29

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 111.15  E-value: 3.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  11 QQYIFGDFVL-KNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYALRKLLHEN- 88
Cdd:COG3710    1 MRYRFGDFRLdPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNSLTQAISRLRKALGDDg 80

                         90       100
                 ....*....|....*....|....*.
gi 447099583  89 KQCKYIETVYGRGYRFTVPIVIVTDN 114
Cdd:COG3710   81 LEPRLIRTVPRRGYRLVAPVEVEAPE 106
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 26-104 1.58e-18

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 80.60  E-value: 1.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  26 LLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWS-ASVASDESLTRCIYALRKLLHENKQCKYIETVYGRGYRF 104
Cdd:cd00383   10 VTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGyDYEVDDRTVDVHISRLRKKLEDDPEPRLIKTVRGVGYRL 89
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 30-104 5.24e-17

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 75.67  E-value: 5.24e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447099583    30 NKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDE-SLTRCIYALRKLLHENKQCKYIETVYGRGYRF 104
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDnTLDVHISRLRKKLEDDGDPRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
30-104 2.19e-16

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 74.09  E-value: 2.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447099583   30 NKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDE-SLTRCIYALRKLLHENKQC-KYIETVYGRGYRF 104
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDnTVDVHISRLRKKLEDDPRDpRLIKTVRGVGYRL 77
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 51-115 1.08e-08

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 57.74  E-value: 1.08e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447099583  51 GEIVSKEEIIDKVWSASVASDESLTRCIYALRKLLHENKQ--CKYIETVYGRGYRFTVPIVIVTDNE 115
Cdd:PRK10153  45 GEVLSRDELIDHVWDRAIVTDHVVTQSISELRKSLKDGREdnPEYIVTVPKRGYKLVAPVIWYSEEE 111
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 256-403 3.20e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 256 DSAVMYMNGRMEMYRytpESLKRALVIFRDCVSTQPQNTLPYCCLAEChisLALLGLSEQkqaittAVTSIEKALEINPS 335
Cdd:COG4783    3 CAEALYALAQALLLA---GDYDEAEALLEKALELDPDNPEAFALLGEI---LLQLGDLDE------AIVLLHEALELDPD 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447099583 336 NSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPN 403
Cdd:COG4783   71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
276-403 1.39e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 1.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 276 LKRALVIFRDCVSTQPQNTLPYCCLAEChisLALLGLSEQkqaittAVTSIEKALEINPSNSQALGLLGLISGLKDEHSV 355
Cdd:COG0457   24 YEEAIEDYEKALELDPDDAEALYNLGLA---YLRLGRYEE------ALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 447099583 356 SNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPN 403
Cdd:COG0457   95 ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 278-403 1.59e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.39  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 278 RALVIFRDCVSTQPQNtlpycclAECHISLALLGLseQKQAITTAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSN 357
Cdd:COG4235    1 EAIARLRQALAANPND-------AEGWLLLGRAYL--RLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAE 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 447099583 358 VLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPN 403
Cdd:COG4235   72 ELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPA 117
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 15-96 3.95e-07

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 50.73  E-value: 3.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  15 FGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYALRKLLHEnkqcKYI 94
Cdd:COG0745  127 VGDLLDLAAREVTRDGEPVELTPKEFRLLELLMRNPGRVVSREQLLEEVWGYDYGDDRTVDVHISRLRKKLED----DLI 202


                 ..
gi 447099583  95 ET 96
Cdd:COG0745  203 ET 204
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 246-470 7.24e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.39  E-value: 7.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  246 SINTQQMPS--LDSAVMYMNGrmemyrytpeSLKRALVIFRDCVSTQPQNTLPYCCLAechisLALLGLSEQKQAITTav 323
Cdd:TIGR02917 289 KSAPEYLPAllLAGASEYQLG----------NLEQAYQYLNQILKYAPNSHQARRLLA-----SIQLRLGRVDEAIAT-- 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  324 tsIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPN 403
Cdd:TIGR02917 352 --LSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPE 429

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447099583  404 kMGISILKLIILYYTS-PLDNAISFALNLnSQNTCNNPIITSILAMFMALKGHNDKAKSLL---LKLEPEH 470
Cdd:TIGR02917 430 -LGRADLLLILSYLRSgQFDKALAAAKKL-EKKQPDNASLHNLLGAIYLGKGDLAKAREAFekaLSIEPDF 498
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 278-470 1.94e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 278 RALVIFRDCVSTQPQNTLPYCCLAECHISLALLglseqkqaiTTAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSN 357
Cdd:COG2956   60 RAIRIHQKLLERDPDRAEALLELAQDYLKAGLL---------DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAI 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 358 VLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTC 437
Cdd:COG2956  131 EVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPD 210

                        170       180       190
                 ....*....|....*....|....*....|...
gi 447099583 438 NNPIITSILAMFMALkGHNDKAKSLLLKLEPEH 470
Cdd:COG2956  211 YLPALPRLAELYEKL-GDPEEALELLRKALELD 242
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
322-403 1.10e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.01  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 322 AVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSnVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALE 401
Cdd:COG3063   11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89


                 ..
gi 447099583 402 PN 403
Cdd:COG3063   90 PS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 372-470 1.11e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.18  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 372 DVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAISF---ALNLNSqntcNNPIITSILAM 448
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLlheALELDP----DEPEARLNLGL 80

                         90       100
                 ....*....|....*....|....*
gi 447099583 449 FMALKGHNDKAKSLL---LKLEPEH 470
Cdd:COG4783   81 ALLKAGDYDEALALLekaLKLDPEH 105
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 322-402 3.20e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.57  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 322 AVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALE 401
Cdd:COG5010   73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152


                 .
gi 447099583 402 P 402
Cdd:COG5010  153 P 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 279-449 6.05e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 279 ALVIFRDCVSTQPQNTLPYCCLAEChisLALLGLSEQkqaittAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNV 358
Cdd:COG3914   97 ALALYRRALALNPDNAEALFNLGNL---LLALGRLEE------ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 359 LFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTCN 438
Cdd:COG3914  168 ALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGP 247

                        170
                 ....*....|.
gi 447099583 439 NPIITSILAMF 449
Cdd:COG3914  248 SELSPFALLYL 258
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 301-403 7.27e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 7.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 301 AECHISLALLGLS-EQKQAITTAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSL 379
Cdd:COG4783    1 AACAEALYALAQAlLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                         90       100
                 ....*....|....*....|....
gi 447099583 380 LCFLNGDLARAFNLIEKSIALEPN 403
Cdd:COG4783   81 ALLKAGDYDEALALLEKALKLDPE 104
PRK15479 PRK15479
transcriptional regulator TctD;
15-103 1.06e-04

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 43.94  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  15 FGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSAS-VASDESLTRCIYALRKLLHENKQckY 93
Cdd:PRK15479 129 LGELIFHDEGYFLLQGQPLALTPREQALLTVLMYRRTRPVSRQQLFEQVFSLNdEVSPESIELYIHRLRKKLQGSDV--R 206

                         90
                 ....*....|
gi 447099583  94 IETVYGRGYR 103
Cdd:PRK15479 207 ITTLRGLGYV 216
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 322-480 1.60e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.59  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  322 AVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALE 401
Cdd:TIGR00990 350 ALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLD 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  402 PNKMgISILKLIILYYTsplDNAISFALNLNSQNTCNNPIITSILAMFMAL---KGHNDKA-KSLLLKLEPEHGLDYTCV 477
Cdd:TIGR00990 430 PDFI-FSHIQLGVTQYK---EGSIASSMATFRRCKKNFPEAPDVYNYYGELlldQNKFDEAiEKFDTAIELEKETKPMYM 505


                  ...
gi 447099583  478 NSL 480
Cdd:TIGR00990 506 NVL 508
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 309-463 2.06e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  309 LLGLSEQKQAittAVTSIEKALEINPSNSQALGLLglisglkdehsvSNVLFKQAH----------LLK--PNSPDVYYY 376
Cdd:TIGR02917 202 LLLSLGNIEL---ALAAYRKAIALRPNNIAVLLAL------------ATILIEAGEfeeaekhadaLLKkaPNSPLAHYL 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  377 QSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAISFaLNLNSQNTCNNPIITSILAMFMALKGHN 456
Cdd:TIGR02917 267 KALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQY-LNQILKYAPNSHQARRLLASIQLRLGRV 345


                  ....*..
gi 447099583  457 DKAKSLL 463
Cdd:TIGR02917 346 DEAIATL 352
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 359-403 2.22e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 2.22e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 447099583 359 LFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPN 403
Cdd:COG5010   76 LLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD 120
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
330-483 2.38e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 330 LEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISI 409
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 410 LKLIILYYTSPLDNAISF---ALNLNSqntcNNPIITSILAMFMALKGHNDKAKSLL---LKLEPEHGLDYTCVNSLYTK 483
Cdd:COG0457   81 NLGLALQALGRYEEALEDydkALELDP----DDAEALYNLGLALLELGRYDEAIEAYeraLELDPDDADALYNLGIALEK 156
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
276-401 2.61e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 276 LKRALVIFRDCVSTQPQNTLPYCCLAEChisLALLGLSEQkqaittAVTSIEKALEINPSNSQALGLLGLISGLKDEHSV 355
Cdd:COG0457   58 YEEALADYEQALELDPDDAEALNNLGLA---LQALGRYEE------ALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 447099583 356 SNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALE 401
Cdd:COG0457  129 AIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAA 174
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 368-469 3.88e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 3.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 368 PNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAISF---ALNLNSqntcNNPIITS 444
Cdd:COG4235   14 PNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELlerALALDP----DNPEALY 89

                         90       100
                 ....*....|....*....|....*...
gi 447099583 445 ILAMFMALKGHNDKAKSL---LLKLEPE 469
Cdd:COG4235   90 LLGLAAFQQGDYAEAIAAwqkLLALLPA 117
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
360-470 5.52e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.82  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 360 FKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAIS-F--ALNLNSQNT 436
Cdd:COG4785   96 FDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIAdLekALELDPNDP 175

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447099583 437 CNnpiitSILAMFMALKGHNDKAKSLLLKLEPEH 470
Cdd:COG4785  176 ER-----ALWLYLAERKLDPEKALALLLEDWATA 204
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 275-403 5.82e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 5.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  275 SLKRALVIFRDCVSTQPQNTLPYCCLAECHISLallglSEQKQAITtavtSIEKALEINPSNSQALGLLGLISGLKDEHS 354
Cdd:TIGR02917 616 DLNKAVSSFKKLLALQPDSALALLLLADAYAVM-----KNYAKAIT----SLKRALELKPDNTEAQIGLAQLLLAAKRTE 686

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 447099583  355 VSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPN 403
Cdd:TIGR02917 687 SAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPS 735
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
37-105 5.96e-04

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 41.63  E-value: 5.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583  37 PKELGVIILLLNADGEIVSKEEIIDKVWSASV-ASDESLTRCIYALRKLLHENKQCKYIETVYGRGYRFT 105
Cdd:PRK10161 157 PTEFKLLHFFMTHPERVYSREQLLNHVWGTNVyVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFS 226
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 359-516 1.04e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 359 LFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAISF---ALNLNSqn 435
Cdd:COG3914  100 LYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAAlrrALELDP-- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 436 tcNNPIITSILAMFMALKGHNDKAKSLL---LKLEPEHglDYTCVNSLYTKFLIYGASIKNDIMKLLANISTNKINGVIL 512
Cdd:COG3914  178 --DNAEALNNLGNALQDLGRLEEAIAAYrraLELDPDN--ADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPF 253


                 ....
gi 447099583 513 PLIY 516
Cdd:COG3914  254 ALLY 257
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 274-470 1.17e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 274 ESLKRALVIFRDCVSTQPQNtlpycclAECHISLALLglSEQKQAITTAVTSIEKALEINPSNSQALGLLGLISGLKDEH 353
Cdd:COG2956   22 GQPDKAIDLLEEALELDPET-------VEAHLALGNL--YRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447099583 354 SVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSPLDNAISF---ALN 430
Cdd:COG2956   93 DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEAlekALK 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 447099583 431 LNSqntcNNPIITSILAMFMALKGHNDKAKSLL---LKLEPEH 470
Cdd:COG2956  173 LDP----DCARALLLLAELYLEQGDYEEAIAALeraLEQDPDY 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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