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Conserved domains on  [gi|447102834|ref|WP_001180090|]
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MULTISPECIES: multidrug efflux MFS transporter MdfA [Enterobacteriaceae]

Protein Classification

MFS transporter( domain architecture ID 11487773)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
7-410 0e+00

MdfA family multidrug efflux MFS transporter;


:

Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 700.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   7 SGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 86
Cdd:PRK15402   3 PLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  87 AGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIH 166
Cdd:PRK15402  83 AGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIH 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 167 VLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIII 246
Cdd:PRK15402 163 VLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVIL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 247 ITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFG 326
Cdd:PRK15402 243 ISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 327 IGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGQFNLFNLVNGILWLSLMVIFLKDKQMGN 406
Cdd:PRK15402 323 IGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPMGN 402


                 ....
gi 447102834 407 SHEG 410
Cdd:PRK15402 403 AHEG 406
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
7-410 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 700.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   7 SGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 86
Cdd:PRK15402   3 PLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  87 AGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIH 166
Cdd:PRK15402  83 AGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIH 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 167 VLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIII 246
Cdd:PRK15402 163 VLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVIL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 247 ITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFG 326
Cdd:PRK15402 243 ISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 327 IGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGQFNLFNLVNGILWLSLMVIFLKDKQMGN 406
Cdd:PRK15402 323 IGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPMGN 402


                 ....
gi 447102834 407 SHEG 410
Cdd:PRK15402 403 AHEG 406
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-398 1.24e-85

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 265.59  E-value: 1.24e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  19 PLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLA 98
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  99 ILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFA 178
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 179 ALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYG 258
Cdd:cd17320  161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 259 LLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLT 338
Cdd:cd17320  241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 339 LFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWlNGGNGQFNLFNLVNGILWLSLMVIF 398
Cdd:cd17320  321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-359 8.99e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 123.55  E-value: 8.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  13 RQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWF 92
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  93 IVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEG 172
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 173 MFVLFAALAAISFFGLQRAMPETATRIGEKlslkeLGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQL 252
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESRPAARAR-----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 253 SSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGgwpimIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANA 332
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG-----LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        330       340
                 ....*....|....*....|....*...
gi 447102834 333 GLVRLTL-FASDMSKGTVSAAMGMLQML 359
Cdd:COG2814  316 LLQALVAeLAPPEARGRASGLYNSAFFL 343
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 32-369 4.03e-30

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 119.80  E-value: 4.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLL 111
Cdd:TIGR00710  20 GIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRA 191
Cdd:TIGR00710 100 RFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  192 MPETATRIgEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAG 271
Cdd:TIGR00710 180 LPETLPYE-ARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFG 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  272 NLLLARLTSRRTVRSLIIMGGWpIMIGLLVAAAATVISSHAYLWMTAGLSIY-AFGIGLANAGLVRLTLFASDMSKGTVS 350
Cdd:TIGR00710 259 GFLNGRFIKKWGAKSLLRMGLI-LFAVSAVLLEITAILGLGSWAMIIGPMMFvGIGNSMISSIAMAYALEDFPHVAGTAS 337

                         330       340
                  ....*....|....*....|
gi 447102834  351 AAMGMLQM-LIFTVGIEISK 369
Cdd:TIGR00710 338 ALFGTLRLvLGAIVGYLVSL 357
MFS_1 pfam07690
Major Facilitator Superfamily;
58-364 2.64e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.47  E-value: 2.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFG--LQRAMPETATRIGEKLSLKELGRDYKLV 215
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLllLPRPPPESKRPKPAEEARLSLIVAWKAL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  216 LKNGRF--VAGALALGFVSLPLLAWIAqspiIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGw 293
Cdd:pfam07690 198 LRDPVLwlLLALLLFGFAFFGLLTYLP----LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL- 272

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447102834  294 pIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSK-GTVSAAMGMLQMLIFTVG 364
Cdd:pfam07690 273 -LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEErGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
7-410 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 700.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   7 SGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 86
Cdd:PRK15402   3 PLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  87 AGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIH 166
Cdd:PRK15402  83 AGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIH 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 167 VLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIII 246
Cdd:PRK15402 163 VLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVIL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 247 ITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFG 326
Cdd:PRK15402 243 ISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 327 IGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGQFNLFNLVNGILWLSLMVIFLKDKQMGN 406
Cdd:PRK15402 323 IGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPMGN 402


                 ....
gi 447102834 407 SHEG 410
Cdd:PRK15402 403 AHEG 406
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
15-403 6.61e-109

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 326.40  E-value: 6.61e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  15 ALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIV 94
Cdd:PRK15403  14 TLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  95 TCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMF 174
Cdd:PRK15403  94 ACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLF 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 175 VLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSS 254
Cdd:PRK15403 174 AIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTT 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 255 YEYGLLQVPIFGALIAGNLLLARLTSRRTvRSLIIMGGWPI-MIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAG 333
Cdd:PRK15403 254 SQFAWTQVPVFGAVIVANAIVARFVKDPT-EPRFIWRAVPIqLVGLALLIVGNLLWPHVWLWSVLGTSLYAFGIGLIFPT 332

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 334 LVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGQFNLFNLVNGILWLSLMVIFLKDKQ 403
Cdd:PRK15403 333 LFRFTLFSNNLPKGTVSASLNMVILMVMAVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVR 402
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-398 1.24e-85

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 265.59  E-value: 1.24e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  19 PLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLA 98
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  99 ILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFA 178
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 179 ALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYG 258
Cdd:cd17320  161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 259 LLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLT 338
Cdd:cd17320  241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 339 LFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWlNGGNGQFNLFNLVNGILWLSLMVIF 398
Cdd:cd17320  321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-359 8.99e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 123.55  E-value: 8.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  13 RQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWF 92
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  93 IVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEG 172
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 173 MFVLFAALAAISFFGLQRAMPETATRIGEKlslkeLGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQL 252
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESRPAARAR-----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 253 SSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGgwpimIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANA 332
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG-----LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        330       340
                 ....*....|....*....|....*...
gi 447102834 333 GLVRLTL-FASDMSKGTVSAAMGMLQML 359
Cdd:COG2814  316 LLQALVAeLAPPEARGRASGLYNSAFFL 343
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 32-369 4.03e-30

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 119.80  E-value: 4.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLL 111
Cdd:TIGR00710  20 GIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRA 191
Cdd:TIGR00710 100 RFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  192 MPETATRIgEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAG 271
Cdd:TIGR00710 180 LPETLPYE-ARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFG 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  272 NLLLARLTSRRTVRSLIIMGGWpIMIGLLVAAAATVISSHAYLWMTAGLSIY-AFGIGLANAGLVRLTLFASDMSKGTVS 350
Cdd:TIGR00710 259 GFLNGRFIKKWGAKSLLRMGLI-LFAVSAVLLEITAILGLGSWAMIIGPMMFvGIGNSMISSIAMAYALEDFPHVAGTAS 337

                         330       340
                  ....*....|....*....|
gi 447102834  351 AAMGMLQM-LIFTVGIEISK 369
Cdd:TIGR00710 338 ALFGTLRLvLGAIVGYLVSL 357
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-398 7.26e-26

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 107.51  E-value: 7.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  22 LVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILL 101
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 102 AQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWI--HVLPWEGMFVLFAA 179
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 180 LAAISFFGLQRAMPETATRIGEK---LSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYE 256
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKneeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 257 YGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGwpiMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVR 336
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG---LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447102834 337 LTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHaWLNGGNGQFNLFNLVNGILWLSLMVIF 398
Cdd:cd06174  318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF-LLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 32-364 7.63e-22

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 96.10  E-value: 7.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLL 111
Cdd:cd17474   14 GVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGaAWIHVLPWEGMFVLFAALAAISFFGLQRA 191
Cdd:cd17474   94 RALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG-GLLAAISWRYPFFLLAALIPVAFLAILFL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 192 MPETATRigEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAG 271
Cdd:cd17474  173 LPEPKEK--AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 272 NLLLARLTSRRtvrsliIMGGWPIMIGLLVAAAATVI--SSHAYLWMTAGLSIYAFGIGLANAGL-VRLTLFASDMSKGT 348
Cdd:cd17474  251 SLFVGRLLKKR------FGARRILVIGLLLYALSLLLlgFVPSLALLLIAIVLFGLGLGLNLPLLtTLVTELAPEEERGT 324

                        330
                 ....*....|....*.
gi 447102834 349 VSAAMGMLQMLIFTVG 364
Cdd:cd17474  325 ASSLYNFVRFLGQAVG 340
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
30-289 9.90e-19

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 87.26  E-value: 9.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  30 YIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFT 109
Cdd:PRK11043  19 FLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 110 LLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITA-LMANVALiAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGL 188
Cdd:PRK11043  99 VLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFAtIMPLVAL-SPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPT 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 189 QRAMPETATRIGEKLSLkelgrDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIitgEQL--SSYEYGLLQVPIFG 266
Cdd:PRK11043 178 LRLKPSKKARKQSQDAL-----TFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFIL---EQMgySPADIGLSYVPQTI 249

                        250       260
                 ....*....|....*....|....*..
gi 447102834 267 ALIAG----NLLLARLTSRRTVRSLII 289
Cdd:PRK11043 250 AFLVGgygcRAALQKWGGEQLLPWLLV 276
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-364 6.19e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 84.55  E-value: 6.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIE 106
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFF 186
Cdd:cd17325   86 QLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 187 GLQRAMPETA-TRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIF 265
Cdd:cd17325  166 LALLLLPEPRpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 266 GALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATvisshAYLWMTAGLSIYAFGIGLAN-AGLVRLTLFASDM 344
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFpATLALLADIVPPE 320

                        330       340
                 ....*....|....*....|
gi 447102834 345 SKGTVSAAMGMLQMLIFTVG 364
Cdd:cd17325  321 GRGTAMGLFNTAFSLGMVLG 340
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 27-303 7.06e-18

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 83.32  E-value: 7.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIE 106
Cdd:COG0477   24 FLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFF 186
Cdd:COG0477  104 LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 187 gLQRAMPETATRIGEKLSLKELGrdykLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFG 266
Cdd:COG0477  184 -LRLRLPESRGLLLALLALALAA----LLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLL 258

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 447102834 267 ALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAA 303
Cdd:COG0477  259 LAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_1 pfam07690
Major Facilitator Superfamily;
58-364 2.64e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.47  E-value: 2.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFG--LQRAMPETATRIGEKLSLKELGRDYKLV 215
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLllLPRPPPESKRPKPAEEARLSLIVAWKAL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  216 LKNGRF--VAGALALGFVSLPLLAWIAqspiIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGw 293
Cdd:pfam07690 198 LRDPVLwlLLALLLFGFAFFGLLTYLP----LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL- 272

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447102834  294 pIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSK-GTVSAAMGMLQMLIFTVG 364
Cdd:pfam07690 273 -LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEErGTASGLYNTAGSLGGALG 343
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
34-247 2.69e-17

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 82.66  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  34 DMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRF 113
Cdd:PRK11102   8 DMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 114 LQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMP 193
Cdd:PRK11102  88 LHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447102834 194 ET-ATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIII 247
Cdd:PRK11102 168 ETlPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYI 222
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 71-368 5.30e-17

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 81.84  E-value: 5.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  71 LLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVA 150
Cdd:cd17321   50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVV 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 151 LIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFglqrampetatrigeklslkeLGRdyklvlkngRFVAGALALGF 230
Cdd:cd17321  130 GIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL---------------------LAR---------TFSGAVLAAFL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 231 VSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLvaAAATVISS 310
Cdd:cd17321  180 LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL--LLALLGAD 257

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447102834 311 HAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSK-GTVSAAMGMLQMLIFTVGIEIS 368
Cdd:cd17321  258 SSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKaGAASGILNTARQLGGALGVALL 316
emrD PRK11652
multidrug transporter EmrD;
58-223 4.66e-16

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 79.18  E-value: 4.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:PRK11652  49 MAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKlslKELGRDYKLVLK 217
Cdd:PRK11652 129 QLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETRPADARR---TRVLASYRTLLS 205


                 ....*.
gi 447102834 218 NGRFVA 223
Cdd:PRK11652 206 NRRFNC 211
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-365 3.34e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.45  E-value: 3.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:COG2271   51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFglqrampetatrigeklslkelgrdyklvlk 217
Cdd:COG2271  131 ERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL------------------------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 218 nGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRsliimGGWPIMI 297
Cdd:COG2271  180 -LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-----RKLVLAI 253

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 298 GLLVAAAATVISSHA--YLWMTAGLSIYAFGIGLANAglVRLTLFASDMSKGTVSAAMGMLQMLIFTVGI 365
Cdd:COG2271  254 GLLLAALALLLLALLpsPALAIALLFLAGFGLGGAFG--LLWALAAELFPKKARGTASGLVNTFGFLGGA 321
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 58-365 5.61e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 72.58  E-value: 5.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17324   40 VSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPE 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETAtriGEKLSLKELGRDYKLVLK 217
Cdd:cd17324  120 KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLP---PKKPGSLGLLSSLLLLLR 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 218 NGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMI 297
Cdd:cd17324  197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447102834 298 GLLVAAAAtvissHAYLWMTAGLSIYAFGIGLANAGlvrLTLFASDMSKGTVSAAMGmLQMLIFTVGI 365
Cdd:cd17324  277 LLLLTLLG-----PSPLLLLVGLVLWGLGFFAAHSA---LQTRVLRLAPEARGLASS-LYLAAYNLGG 335
2_A_01_02 TIGR00880
Multidrug resistance protein;
59-195 8.74e-14

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 68.06  E-value: 8.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   59 TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAV 138
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 447102834  139 CIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPET 195
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
32-330 1.79e-13

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 71.21  E-value: 1.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLL 111
Cdd:PRK10473  18 GIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAI----SFFG 187
Cdd:PRK10473  98 RFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILvlllSLFI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 188 LQRAMPetaTRIGEKLSLKELGRDyklVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGA 267
Cdd:PRK10473 178 LKETRP---ARAPAASSKPRENSE---SLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGEYAIIMALTAGV 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447102834 268 LIAGNLLLARLTSRRTVRSLIIMGgwpimIGLLVAAAATVISSHAYLWMTAGLSI----YAFGIGLA 330
Cdd:PRK10473 252 SMTVSFSTPFALGIFKPRTLMLTS-----QVLFLAAGITLALSPSHAVSLFGITLicagFSVGFGVA 313
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 67-392 1.40e-12

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 68.40  E-value: 1.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  67 FLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGIslCFIGAVGYAAIQESFEEAVCIKITALM 146
Cdd:cd17472   47 IFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 147 ANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELgrdYKLVLKNGRFVAGAL 226
Cdd:cd17472  125 GASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKK---LKKLLKNKRLLRLDF 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 227 ALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGgwpiMIGLLVAAAAT 306
Cdd:cd17472  202 SIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSS----ILLIAVGFLLL 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 307 VISSHAYLWMTAGLSIYAFGIGLANAGLVRL-TLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGQFNLFNL 385
Cdd:cd17472  278 LFAATSLWLLIIGLIIFFIGFNLLEALLPSLvSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTIL 357


                 ....*..
gi 447102834 386 VNGILWL 392
Cdd:cd17472  358 ILALLWL 364
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
58-332 5.97e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.83  E-value: 5.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:COG2223   46 FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATriGEKLSLKELGRDYKLVLK 217
Cdd:COG2223  126 RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA--GAAAAAKASLRDQLEALR 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 218 NGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQ--VPIFGAL--IAGNLLLARLTSRRTVrsliimggW 293
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAalFALLGALgrPLGGWLSDRIGGRRVL--------L 275

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 447102834 294 PIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANA 332
Cdd:COG2223  276 IVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 27-186 6.85e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 66.44  E-value: 6.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIE 106
Cdd:cd17323    9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFF 186
Cdd:cd17323   89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLI 168
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 75-365 1.44e-11

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 65.29  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  75 LSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAP 154
Cdd:cd17503   54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 155 LLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGlqrampetatrigekLSLKELGrdyklVLKNGRFVAGALALGFVSLP 234
Cdd:cd17503  134 AIGPTLGGWLTDNLSWRWIFYINLPIGILALLL---------------APLLDLR-----LFKDRNFTLGLLLSFLLGLG 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 235 LLAWIAQSPIIIITGEQLSSYEYGLLQVPifGALIAGnlLLARLTSRRTVRsliIMGGWPIMIGLLVAAAATVISSH--- 311
Cdd:cd17503  194 LFGAMFLLPLYLQNVLGYSAFESGLVLAP--GGLASA--ILSPLVGRLLDK---FGPRLLLLAGLLLLALGTLLLAFltp 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447102834 312 --AYLWMTAGLSIYAFGIGLANAGLVRLTLfaSDMSKGTVSAA---MGMLQMLIFTVGI 365
Cdd:cd17503  267 dtSLWLIILPLFIRGLGMGLVFMPLNTLAL--NSLPPEQIGDAtalFNTIRQLGGSIGT 323
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 31-364 3.44e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 61.09  E-value: 3.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  31 IGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLA-----GVVWFIVTCLAILLAQNI 105
Cdd:cd06173   13 LGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 106 EQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISF 185
Cdd:cd06173   93 WLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSA 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 186 FGLQ--RAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVP 263
Cdd:cd06173  173 LLLLfiRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 264 IFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAatvisSHAYLWMTAGLSIYAFGIGLANAGL-VRLTLFAS 342
Cdd:cd06173  253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVP 327

                        330       340
                 ....*....|....*....|..
gi 447102834 343 DMSKGTVSAAMGMLQMLIFTVG 364
Cdd:cd06173  328 DELRGRVFSVYNALNSGAMPLG 349
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 35-364 7.86e-10

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 59.90  E-value: 7.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  35 MIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFL 114
Cdd:cd17504   14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 115 QGISLCFIGaVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFglqrAMPE 194
Cdd:cd17504   94 QGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA----LVPL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 195 TATRIgeklsLKElgRDYKLVLKNGRFVAGALALGFVSLPLLawiAQSPIIIITGeqLSSYEYGLLQVPIFGALIAGNLL 274
Cdd:cd17504  169 IDLRL-----LRR--RNVLLANITALLAGFGMFMVFQLLPQL---LQLPTPTGFG--LGITEAGLLLLPGALVMLIAGPL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 275 LARLTSRRTVRSLIIMGGWPIMIGLLvaAAATVISSHAylWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKgtVSAAMG 354
Cdd:cd17504  237 AGRLIARVGPRRVLLIGLVISAVGLL--LLALLHSSLW--ALVVALLLIGIGLGLAFASLPNIVVESVPPDR--TGIATG 310

                        330
                 ....*....|
gi 447102834 355 MLQmLIFTVG 364
Cdd:cd17504  311 MNT-VLRTIG 319
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 59-376 8.71e-10

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 59.88  E-value: 8.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  59 TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAV 138
Cdd:cd17502   37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 139 CIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQrampetatrigeklslkelgrdyklvlkn 218
Cdd:cd17502  117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALLR----------------------------- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 219 gRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSR-RTVRSLIIMGGwpiMI 297
Cdd:cd17502  168 -TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtGRYKPLIVIGT---IL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 298 GLLVAAAATVISSHAYLWMTAGLS-IYAFGIGLAN-AGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNG 375
Cdd:cd17502  244 MSVGAGLLTTLTLDTSKWLLIGYLiLLGLGLGIGFqQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFLVAL 323


                 .
gi 447102834 376 G 376
Cdd:cd17502  324 A 324
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 62-196 3.67e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 58.08  E-value: 3.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  62 LAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIK 141
Cdd:cd17371   44 LAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGK 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447102834 142 ITALMANVALIAPLLGPLVGAAWIHVLP----WEGMFvLFAALAAISFFGLQRAMPETA 196
Cdd:cd17371  124 ALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLF-LLGALPALLVLFIRRFVKEPP 181
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 22-326 7.39e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 57.24  E-value: 7.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  22 LVLYEFSTYIGNDMIQPGM-LAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAIL 100
Cdd:cd17329    4 LLIGSFLNRLGFFMVWPFMaIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 101 LAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGaAWIHVLPWEGMFVLFAAL 180
Cdd:cd17329   84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 181 AAISFFGLQRAMPETATRIGEKLsLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLL 260
Cdd:cd17329  163 FLLAALVLLFLLPETRPKRRAAE-KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447102834 261 qVPIFGALI-AGNLLLARLTSRRTVRSLIIMGgwpimIGLLVAAAATVISSHAYLWMTAGLSIYAFG 326
Cdd:cd17329  242 -LALNALLIvLLQFPVARLVERFRLRKILMIG-----ILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 27-328 7.80e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.83  E-value: 7.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIE 106
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFF 186
Cdd:cd17489   86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 187 GLQRAMPETATRIGEklslKELGRDYKLVLKNGRFVAGALALGFVSLPLLAwiaqspiiIITGEQLSSYEYGLLQVPIFG 266
Cdd:cd17489  166 LVFLVKDPPPVAAEE----AEAGTRAFRRLVEKKVLPPALILFLASIAYGA--------ISTFLPLYAAERGISNAGLFF 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447102834 267 ALIAGNLLLARLTSRRTvrSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIG 328
Cdd:cd17489  234 TVYAIALLLSRPFSGKL--SDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG 293
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 41-334 8.12e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 56.84  E-value: 8.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  41 LAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLC 120
Cdd:cd17316   25 LAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 121 FIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLP----WEGMFVLFAALAAISFFGLqrampeta 196
Cdd:cd17316  105 GEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLALLLR-------- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 197 trigeklslkelgrdyklvlknGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLA 276
Cdd:cd17316  177 ----------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447102834 277 RLTSRRTVRSLIIMGgwpIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGL 334
Cdd:cd17316  235 LLSDRIGRKKTLVIG---LILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAL 289
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 58-228 1.32e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 56.21  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:TIGR00895  58 FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKR 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLK 217
Cdd:TIGR00895 138 FRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQ 217

                         170
                  ....*....|.
gi 447102834  218 NGRFVAGALAL 228
Cdd:TIGR00895 218 MQAEAQSALPE 228
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 58-183 2.33e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 55.28  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17365   40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPAR 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 447102834 138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAI 183
Cdd:cd17365  120 RRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI 165
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 58-356 5.85e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 54.11  E-value: 5.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17319   44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 138 VCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLqrampetatrigeklslkelgrdYKLVLK 217
Cdd:cd17319  124 ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLW-----------------------WFYLRQ 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 218 NGRFVAGALALGFVSLPLLAWIaqsPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSliimGGWPIMI 297
Cdd:cd17319  181 VWGLALGYFGINYALYGLLTWL---PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA----RRLVIII 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447102834 298 GLLVAAAATVISSHAY-LWMT-AGLSIYAFGIGLANAGL-VRLTLFASDMSKGTVSAAMGML 356
Cdd:cd17319  254 GLLLAAVGLLLAYLTTsPVVAvILLSLAGFGIGAASPVFwSLPADLLPGEAAATAGGLINSG 315
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 53-132 1.73e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 52.58  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  53 WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQE 132
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 72-183 2.42e-06

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 49.27  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  72 LGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVAL 151
Cdd:cd17396   55 AGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSF 134

                         90       100       110
                 ....*....|....*....|....*....|..
gi 447102834 152 IAPLLGPLVGAAWIHVLPWEGMFVLFAALAAI 183
Cdd:cd17396  135 GQFLLPFIIAFLAANNLWYGWSFIVPAAVLVL 166
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-196 4.94e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.33  E-value: 4.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRR--PVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFE 135
Cdd:COG2271  222 LSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447102834 136 EAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETA 196
Cdd:COG2271  302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
73-331 6.46e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 6.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  73 GPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALi 152
Cdd:COG0738   64 GRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSL- 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 153 APLLGPLVGAAWIHV---LPWEGMFVLFAALAAISFFGLQRA-MPETATRIGEKlslKELGRDYKLVLKNGRFVAGALAL 228
Cdd:COG0738  143 GALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSkLPEIEEEEEEA---AGSAASLKSLLKNPRLLLGGLAI 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 229 GFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVi 308
Cdd:COG0738  220 FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPG- 298

                        250       260
                 ....*....|....*....|...
gi 447102834 309 sshaylWMTAGLSIYAFGIGLAN 331
Cdd:COG0738  299 ------PWLALIGLALVGLGLSL 315
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
65-332 9.43e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.59  E-value: 9.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  65 GMFLQWLLGPLSDRIG-----RRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFigAVGYAAIQESFEEAVC 139
Cdd:COG2211   59 DAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLL--GLAYTLVNIPYSALGA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 140 ---------IKITALMANVALIAPLLGPLVGAAWIHVLP------WEGMFVLFAALAAISFFGLQRAMPETATRIGEKLS 204
Cdd:COG2211  137 eltpdyeerTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 205 LKElgrDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTV 284
Cdd:COG2211  217 LKE---SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK 293

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 447102834 285 RSLIIMGgwpIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANA 332
Cdd:COG2211  294 KKAFIIG---LLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILV 338
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 58-334 3.53e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.65  E-value: 3.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVG-YAAIQESFEE 136
Cdd:cd17330   40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQaYIADITDEEE 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 137 avcikITALMANVAL---IAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPetatrigeklslkelgrdyk 213
Cdd:cd17330  120 -----RAKAFGIISAafgLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP-------------------- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 214 lvlkngrFVAGALALGFVSlpLLAWIAQSPIIIITGEQ---LSSYEYGLLQVPI-FGALIAGNLLLARLTSRRTVRSLII 289
Cdd:cd17330  175 -------PLRRLLLVYFLI--ALAFAGLESVFSLFLKDrfgFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLR 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 447102834 290 MGGWPIMIGLLVAAAATVISshaylWMTAGLSIYAFGIGLANAGL 334
Cdd:cd17330  246 LGLLLAIIGLLLLPFASSVP-----LLVLAAAILAFGTGIVFPAL 285
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
59-364 3.85e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.63  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  59 TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAV 138
Cdd:COG2807   60 TLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 139 CIkITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSlkelGRDYKLVLKN 218
Cdd:COG2807  140 GL-MTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA----AASLRSLWRS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 219 GRFVAGALALGFVSLPLLAWIAQSPIIIIT---GEQLSSYEYGLLQ-VPIFGALIAGnLLLARLTSRRTVrsliimggwp 294
Cdd:COG2807  215 PLAWLLTLFFGLQSLLYYAVVAWLPPILRDaglSAATAGLLLSLFQlAGIPGSLLVP-LLADRLGDRRPL---------- 283

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447102834 295 imigLLVAAAATVISSHAYLWMTAGLS-IYAFGIGLANAGLVRLTL-FASDMSK--GTVSAAMGMLQMLIFTVG 364
Cdd:COG2807  284 ----LLLLGLLGLAGLLGLLLAPGSLPwLWAVLLGLGQGGLFPLALtLIGLRARtpAEAAALSGMAQSVGYLLA 353
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 71-361 3.92e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 45.26  E-value: 3.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  71 LLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIK----ITALM 146
Cdd:cd17473   54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKmlglQSAAM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 147 ANVALIAPLLGPLVGAawihvLPWEGMFVLFaALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLvlkNGRFVAGAL 226
Cdd:cd17473  134 SLGGVVFLLLGGALAE-----IGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASPGAATAAALP---WKRVLPIYF 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 227 ALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLiimggwpIMIGLLVAAAAT 306
Cdd:cd17473  205 LAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL-------LAIGFALMALGF 277

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447102834 307 VISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLIF 361
Cdd:cd17473  278 LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFF 332
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 53-185 4.18e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 45.33  E-value: 4.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  53 WVPTSMTayLAGGMFLqWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQE 132
Cdd:cd17476   37 WLAASYS--LTVGTFI-LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGR 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 447102834 133 SFEEAVCIKIT-ALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISF 185
Cdd:cd17476  114 TYPPGPRKNIVfSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVA 167
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 50-183 7.52e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.47  E-value: 7.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  50 GIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAI-LLAQNIEQFTLLRFLQGISLCFIGAVGYA 128
Cdd:cd17477  221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLpLVPGLPLALLVLLFLWGGAAGPLYTLALA 300

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447102834 129 AIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAI 183
Cdd:cd17477  301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
20-131 3.32e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  20 LCLVLYEFSTYIGNDMIQPGMLAVVEQY-QAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLA 98
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447102834  99 ILLAQNiEQFTLLrflqgISLCFIGAVGYAAIQ 131
Cdd:COG2211  311 LFFLGP-GNLWLL-----LVLAALAGIGLGAIL 337
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 40-365 3.37e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 42.64  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  40 MLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGI-- 117
Cdd:cd17355   26 IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGgg 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 118 SLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAwIHVLPWEGMFVLFAALAAI----SFFGLQRAMP 193
Cdd:cd17355  106 AGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAAL-IEAFGWRTALLVLALLALLvlvpVLLLLRRRPA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 194 ETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIitGEQLSSYEYGLLQVPIFGAL-IAGN 272
Cdd:cd17355  185 DLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL--ADRGISPAAAAVALALIGLFnIVGR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 273 LLLARLTSRRTVRSLIImggwPIMIGLLVAAAATVISSHAYLWmtagLSIYAFGIGLANAGLVRLT-LFASDMSKGTVSA 351
Cdd:cd17355  263 LLSGWLGDRYSPRRLLA----ASYALRALGLALLLLLPFPPLA----LLLFAALFGLGWGATVPLTaALAARYFGARSYG 334

                        330
                 ....*....|....
gi 447102834 352 AMGMLQMLIFTVGI 365
Cdd:cd17355  335 TLFGLVFAPHQLGS 348
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 71-186 4.99e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 4.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  71 LLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCiKITALMANVA 150
Cdd:cd17471  254 LAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPG-LATTLYSNAS 332

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447102834 151 LIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFF 186
Cdd:cd17471  333 RIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 52-185 6.66e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.39  E-value: 6.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  52 DWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQ 131
Cdd:cd17477   31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLN 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 447102834 132 ESFEEAVCIKITALMANVALIAPLLGPLVgAAWIHVLPWEgMFVLFAALAAISF 185
Cdd:cd17477  111 ALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGAL-PFLIAAVLLLLAL 162
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 58-188 8.28e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 8.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17325  241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 447102834 138 VCIKITAL----MANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGL 188
Cdd:cd17325  321 GRGTAMGLfntaFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 62-128 9.14e-04

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 40.99  E-value: 9.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447102834  62 LAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYA 128
Cdd:cd17444   46 LVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYA 112
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 70-332 1.16e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 40.74  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  70 WLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQ--------FTLLRFLQGISLCFIGAVGYAAIQESFEE----- 136
Cdd:cd17367   58 WLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPgrrgf 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 137 -AVCIKITALMANV--ALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFgLQRAMPETATRIGEKLSLKELGRDYK 213
Cdd:cd17367  138 ySSFQYVTLIGGQLlaLGVLLVLQHTLGEDQMAAWGWRIPFLLGGVLAVVVLW-LRRGLEETESFEAIAESNEASAGTLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 214 LVLKNGRfvAGALALGFV---SLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLII- 289
Cdd:cd17367  217 ELRRHPR--ELLLVVGLTaggTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLf 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 447102834 290 --MGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANA 332
Cdd:cd17367  295 fgIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAV 339
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 64-117 1.34e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 40.64  E-value: 1.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 447102834  64 GGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGI 117
Cdd:cd17358   53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGF 106
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 73-335 1.55e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  73 GPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFI-GAVGYAAIQESFEE---AVCIKITALMAN 148
Cdd:cd17391   57 GRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVpNATALIASQTPKEKsgwALGTLSTGVVAG 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 149 ValiapLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPE--TATRIGEKLSLKELGRdyklVLKNGRFVAGAL 226
Cdd:cd17391  137 T-----LIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEdfKPVEKKKMVSTKEVWN----SVPNPSLLISLF 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 227 ALGFVSLPLLAWIAqsPIIIITGEQLSSYEYGLLQVP--IFGALIAGNLLLARLTSRRTVRsliiMGGWPIMIGLLVAAA 304
Cdd:cd17391  208 VTTFIIQLANQSIE--PILTLYIRQLMGDASNLAFISglVFSATGVSSLLSAPRLGKLGDR----IGHHRILLGALLASA 281

                        250       260       270
                 ....*....|....*....|....*....|.
gi 447102834 305 ATVISShAYLWMTAGLSIYAFGIGLANAGLV 335
Cdd:cd17391  282 LLYIPQ-AFVQTPWQLGILRFLLGLATGGLL 311
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 55-119 2.63e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 39.58  E-value: 2.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447102834  55 PTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISL 119
Cdd:cd17374   38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAV 102
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 71-188 2.70e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.92  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  71 LLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGaVGYAAIQESFEEAVCIKITALMANVA 150
Cdd:cd06179   51 IVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQGVVNLVA 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 447102834 151 LIAPLLGPLVGAAWIHVLP--WEGMFVLFAALAAISFFGL 188
Cdd:cd06179  130 SPGSALGPLIAGALVEANAagWRWIFYINAIFNALALILL 169
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 54-117 3.32e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 39.38  E-value: 3.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447102834  54 VPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGI 117
Cdd:cd17377   41 VSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGV 104
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 34-176 3.42e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 39.67  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   34 DMIQPGMLAVVEQYQAGIDWVptsMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRF 113
Cdd:TIGR00711  22 NVAIPTIAGDLGSSLSQVQWV---ITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447102834  114 LQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVL 176
Cdd:TIGR00711  99 IQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 71-186 5.30e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  71 LLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVA 150
Cdd:cd06173  263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447102834 151 LIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFF 186
Cdd:cd06173  343 SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 58-124 6.46e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 38.43  E-value: 6.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLA-QNIEQFTLLRFLQGISLCFIGA 124
Cdd:cd17367  265 TTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAlDHTDSPYTAFALVLVGLVFLSG 332
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 35-363 6.67e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 38.75  E-value: 6.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834   35 MIQPGMLAVVEQYQAGIdWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLL--- 111
Cdd:PRK08633   31 LIQNTLIKAYDGSEQVI-LTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAfav 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  112 RFLQGISLCFIGAVGYAAIQE-----------SFEEAVCI-KITALMANVALIAPLLGPLVGAAW---IHVLPWegMFVL 176
Cdd:PRK08633  110 TFLLGAQSAIYSPAKYGIIPElvgkenlsranGLLEAFTIvAILAGTALFSFLFESVNGNTPSEIlgrIAPAGL--VLLA 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  177 FAALAAISFFGLQRaMPETATRIGEK---LSLKELGRDYKLVLKNG---RFVAGALALGFVSLPLLAWIaQSPIIIITGE 250
Cdd:PRK08633  188 VAVLGLIFAYRLPK-VPAAAPEVFDKkkyLFPKLLWRNLKLLRSDRvlwLAIIGLSYFWFISQLAQANF-PAYAKEVLGL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  251 QLSSYEYGLLQVPIFGaLIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAylwmtagLSIYAFGIGla 330
Cdd:PRK08633  266 DNTFQVQYLLAASAIG-IGIGSLLAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVL-------VLFFLFGFS-- 335

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 447102834  331 nAGLVRLTL------FASDMSKGTVSAA------MGMLQMLIFTV 363
Cdd:PRK08633  336 -AGLFIVPLnaliqfRAPEKELGKVLAAnnflqnVGMLLFLALTT 379
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 58-186 9.05e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 37.97  E-value: 9.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTC--LAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIQESFE 135
Cdd:cd17316  219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP 298

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 447102834 136 EAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFF 186
Cdd:cd17316  299 TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
Sugar_tr pfam00083
Sugar (and other) transporter;
60-119 9.50e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.02  E-value: 9.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447102834   60 AYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVT---CLAILLAQNIEQFTLLRFLQGISL 119
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGavlQGAAKGKWSVYQLIVGRVLVGIGV 116
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 27-188 9.66e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 37.99  E-value: 9.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834  27 FSTYIGNDMIQPGMLAVvEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIE 106
Cdd:cd17313  257 FTDYMGEEVYHGTSAAS-SHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVT 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447102834 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAV--CIKITALMANVALIAPLLGPLVGAAWIHVlpwEGMFVLFAALAAIS 184
Cdd:cd17313  336 VALVLFALGGIGWATININPYPLVSDYHSESGrgQGTDTGLLNLAISLAQILVSLLAGPIIDV---KGYGTVFPVAAVAS 412


                 ....
gi 447102834 185 FFGL 188
Cdd:cd17313  413 FLSL 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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