|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-432 |
3.55e-94 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 287.56 E-value: 3.55e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 25 VFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITM 104
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQD--WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 105 GLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGI 184
Cdd:cd17365 79 LLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 185 GMIPLLLIPFIIRylpesiqfllsrnrqeevdkilnrfqiefyakdethqapsnirkkngfltlfskeyikATLLFWITY 264
Cdd:cd17365 159 GGVPPLILLPLLR----------------------------------------------------------GTLLLWVTF 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 265 IMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKP-SV 343
Cdd:cd17365 181 FMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPaSL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 344 SIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLA 423
Cdd:cd17365 261 VLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALG 340
|
....*....
gi 447105862 424 AISVFFIPT 432
Cdd:cd17365 341 ALAVLLLRL 349
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-403 |
4.63e-79 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 249.97 E-value: 4.63e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 17 SNSITKLVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICC 96
Cdd:TIGR00895 11 LSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAE--WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 97 LALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDF 176
Cdd:TIGR00895 89 ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 177 GWRIMFGIG-MIPLLLIPFIIRYLPESIQFLLSRnRQEEVDKILNRF--QIEFYAKDETHQAPSNIRKKNG-FLTLFSKE 252
Cdd:TIGR00895 169 GWRSLFYVGgIAPLLLLLLLMRFLPESIDFLVSK-RPETVRRIVNAIapQMQAEAQSALPEQKSTQGTKRSvFKALFQGK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 253 YIKATLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAI 332
Cdd:TIGR00895 248 TARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVF 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447105862 333 CIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIM 403
Cdd:TIGR00895 328 AVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-428 |
1.33e-46 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 163.93 E-value: 1.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 25 VFICWLAILADGYDLGIYGAVLPKLLEDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITM 104
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 105 GLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFML----EDFGWRI 180
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 181 MFGIGMIPLLLIPFIIRYlpesiqfllsrnrqeevdkilnrfqiefyakdethqapsnirkkngfltlfskeyikaTLLF 260
Cdd:cd17316 161 LFLIGALPALLALLLRRR----------------------------------------------------------TLLL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 261 WITYIMGMFLIYGLNTWLPQMMRQA-GYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTI 339
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 340 KPSVSIIYLLIG--LAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFS 417
Cdd:cd17316 263 LLSGSPTLLLLLlfILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILA 342
|
410
....*....|.
gi 447105862 418 FAGLLAAISVF 428
Cdd:cd17316 343 LLAIVALIVAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-433 |
1.01e-44 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 159.27 E-value: 1.01e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSI 102
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQAD--LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 103 TMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMF 182
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 183 GIGMIPLLLIPFIirylpesiqfllsrnrqeevdkilnrfqiefyakdethqapsnirkkngfltlfskeyikATLLFWI 262
Cdd:COG2271 168 LILGLPGLLLALL------------------------------------------------------------RFWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 263 TYIMGMFLIYGLNTWLPQMMRQA-GYPLGSSLSFLLMLNITAAIGALFAGAIADRIGA--KIVISISYLMAAICIGLLTI 339
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 340 KPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMqYDLAWNFYLFSFA 419
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA-TGYQAAFLLLAAL 346
|
410
....*....|....
gi 447105862 420 GLLAAISVFFIPTK 433
Cdd:COG2271 347 ALLAALLALLLLRE 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-433 |
7.69e-44 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 157.46 E-value: 7.69e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMG 105
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAE--FGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 106 LAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFML----EDFGWRIM 181
Cdd:cd17371 80 LCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 182 FGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDkilnrfqiefyakdethQAPSnirkkngFLTLFSKEYIKATLLFW 261
Cdd:cd17371 160 FLLGALPALLVLFIRRFVKEPPQWQAARAARRHFA-----------------DRPS-------LRELFSPPLLRTTLLAS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 262 ITYIMGMFLIYGLNTWLPQMMRQA-GYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIK 340
Cdd:cd17371 216 LLATGALGGYYGITTWLPSYLTGErGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 341 P-SVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMqYDLAWNFYLFS-F 418
Cdd:cd17371 296 PlSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATS-GSLGTAIAVFAaV 374
|
410
....*....|....*
gi 447105862 419 AGLLAAISVFFIPTK 433
Cdd:cd17371 375 YYIAGLVLALLLPET 389
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
17-405 |
7.98e-44 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 157.82 E-value: 7.98e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 17 SNSITKLVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICC 96
Cdd:PRK11551 9 SSSRLALTIGLCFLVALLEGLDLQSAGVAAPRMAQE--FGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 97 LALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDF 176
Cdd:PRK11551 87 VALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 177 GWRIMFGIGMI-PLLLIPFIIRYLPESIQFLlsrnrqeevdkilnrfqiefyakdethQAPSNIRKKNGFL-TLFSKEYI 254
Cdd:PRK11551 167 AWRHIFYVGGVgPLLLVPLLMRWLPESRAFA---------------------------QAAGAGKQRAPVLrALFGEGRA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 255 KATLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYlmAAICI 334
Cdd:PRK11551 220 TATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIY--AGILA 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447105862 335 GLLTIKPSVSIIYLLIG--LAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTM 405
Cdd:PRK11551 298 SLAALAAAPSFAGMLLAgfAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-392 |
4.65e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.18 E-value: 4.65e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 21 TKLVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALF 100
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD--LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 101 SITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRI 180
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 181 MFGIGMIP-LLLIPFIIRYLPESIQFLLSRNRQEEVDKILNRfqiefyakdethqapsnirkkngfltlfskeyikATLL 259
Cdd:COG2814 166 VFLVNAVLaLLALLLLLRLLPESRPAARARLRGSLRELLRRP----------------------------------RLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 260 FWITYIMGMFLIYGLNTWLPQMM-RQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLT 338
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447105862 339 IKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGA 392
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-433 |
8.85e-33 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 127.69 E-value: 8.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSI 102
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEE--FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 103 TMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMF 182
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 183 GIGMIPLLLIPFIIRylpesiqfllsrnrqeevdkilnrfqieFYAKDETHQAPSNIRKK-NGFLTLFSkeyIKATLLFW 261
Cdd:COG2223 163 LILGILLLVVAVLAW----------------------------LFLRDPPAGAAAAAKASlRDQLEALR---DPRFWLLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 262 ITYIMGMFLIYGLNTWLPQMMR-QAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISY-LMAAICIGLLTI 339
Cdd:COG2223 212 LLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFaLMALGLLLLALA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 340 KPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFA 419
Cdd:COG2223 292 LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVL 371
|
410
....*....|....
gi 447105862 420 GLLAAISVFFIPTK 433
Cdd:COG2223 372 ALVALVLTLLLYRR 385
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
71-431 |
4.48e-28 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 115.88 E-value: 4.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 71 FGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFI 150
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIV 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 151 YALMFTGYPLGIVLGAILSMFMLEdfgWRIMFGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILNR--------F 222
Cdd:TIGR00898 218 GTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRiakingkkL 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 223 QIEFYAKDETHQAPSNiRKKNGFLTLF-SKEYIKATLLFWITYIMGMFLIYGLntwlpqMMRQAGypLGSSLSFLLMLNI 301
Cdd:TIGR00898 295 PAEVLSLSLEKDLSSS-KKQYSFLDLFrTPNLRKTTLCLMMLWFTTAFSYYGL------VLDLGN--LGGNIYLDLFISG 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 302 TAAIGALFAGAIA-DRIGAKIVISISYLMAAICIGLLTIKPsVSIIYLLIGLAGIGSVGITQILNA---YVTQYFPSHIR 377
Cdd:TIGR00898 366 LVELPAKLITLLLiDRLGRRYTMAASLLLAGVALLLLLFVP-VDLYFLRTALAVLGKFGITSAFQMvylYTAELYPTVVR 444
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447105862 378 ATSLGWGLGLGRVGAIAGPILVgiiMTMQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:TIGR00898 445 NLGVGVCSTMARVGSIISPFLV---YLGEKWLFLPLVLFGGLALLAGILTLFLP 495
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-430 |
3.85e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 108.82 E-value: 3.85e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 28 CWLAILADGYDLGIYGAVLPKLLEdnSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLA 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE--SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 108 ALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMI 187
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 188 PLLL-IPFIIRYLPESiqfllsrnrqeevdkilnrfqiefyAKDETHQAPSNIRKKNGFLTLFSKEYIkatLLFWITYIM 266
Cdd:cd17325 159 LALLaLVLALLLLPEP-------------------------RPPPNKRAVSAARLRSGLRLLLRDRRL---LALFLAIFV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 267 GMFLIYGLNTWLPQMMRQAGyPLGSSLSFLLML--NITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVS 344
Cdd:cd17325 211 LAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGaqGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFW 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 345 IIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTmQYDLAWNFYLFSFAGLLAA 424
Cdd:cd17325 290 LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAA 368
|
....*.
gi 447105862 425 ISVFFI 430
Cdd:cd17325 369 VLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-396 |
1.84e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.35 E-value: 1.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 29 WLAILADGYDLGIYGAVLPKLLEDnSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAA 108
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 109 LAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIgMIP 188
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI-LAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 189 LLLIPFIIRYLPESiqfllsrnrqeevdkilnrfqiefyaKDETHQAPSNIRKKNGFLTLFSKEYIKATLLFWITYIMGM 268
Cdd:pfam07690 160 LSLLAAVLLLLPRP--------------------------PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 269 FLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAK---IVISISYLMAAICIGLLTIKPSVSI 345
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 447105862 346 IYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGP 396
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-430 |
4.92e-25 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 105.35 E-value: 4.92e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGIYGAVLPKLLednswALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSI 102
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTIMKDL-----GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 103 TMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMF 182
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 183 GIGMIPLLLIpfiirylpesiqfllsrnrqeevdkilnrfqiefyakdethqapsnirkknGFLTLFskeYIKATLLFWI 262
Cdd:cd17319 161 IIEGLLGLLL---------------------------------------------------AVLWWF---YLRQVWGLAL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 263 TYIMGMFLIYGLNTWLPQMMRQA-GYPLGSSLSFLLMLNITAAIGALFAGAIADRI---GAKIVISISYLMAAICIGLLT 338
Cdd:cd17319 187 GYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAY 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 339 IKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSF 418
Cdd:cd17319 267 LTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAA 346
|
410
....*....|..
gi 447105862 419 AGLLAAISVFFI 430
Cdd:cd17319 347 VALLAALLVLLL 358
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
22-433 |
8.98e-24 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 102.70 E-value: 8.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 22 KLVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFS 101
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKAD--LGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 102 ITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIM 181
Cdd:PRK12307 95 VGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 182 FGIGMIPLLLIPFIIRYLPESIQFLLSRnrqeevdkilnrfqiefYAKDETHQAPSNIRKKNGFLTLFSKEYIKATLLFW 261
Cdd:PRK12307 175 FFVGLLPVLLVIYIRARAPESKEWEEAK-----------------LSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 262 ITyimgMFLIYG----LNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLL 337
Cdd:PRK12307 238 IV----LFSIFGanwpIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 338 TIKPSVSiiYLLIGLAGIG----SVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGII-MTMQYDLAWN 412
Cdd:PRK12307 314 FRIPQDN--YLLLGACLFGlmatNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLgITMGLGAALT 391
|
410 420
....*....|....*....|.
gi 447105862 413 FYLFSFAGLLAAISVFFIPTK 433
Cdd:PRK12307 392 FIVAFWTATILLIIGLSIPDR 412
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
56-430 |
1.92e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.01 E-value: 1.92e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 56 ALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTAS 135
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 136 ALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMF-GIGMIPLLLIPFIIRYLPesiqfllsrnrqee 214
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFlAIAVLALLAALLLWRLLP-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 215 vdkilnrfqiefyakDETHQAPSNIRKKNGFLTLFSKeyiKATLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLS 294
Cdd:cd17324 176 ---------------SLPPKKPGSLGLLSSLLLLLRN---PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 295 FLLML-NITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFP 373
Cdd:cd17324 238 GLLLLfGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447105862 374 SHiRATSLGWGLGLGRVGAIAGPILVGIIMTMqydLAWNFYLFSFAGLLAAISVFFI 430
Cdd:cd17324 318 EA-RGLASSLYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-202 |
2.81e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 96.42 E-value: 2.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 11 STKTIFSNSITKLVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRK 90
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAAD--LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 91 WTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSM 170
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159
|
170 180 190
....*....|....*....|....*....|..
gi 447105862 171 FMLEDFGWRIMFGIGMIPLLLIPFIIRYLPES 202
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGLLALVLRLRLPES 191
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-428 |
4.51e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 97.11 E-value: 4.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 29 WLAILADGYDLGIYGAVLPKLLEDNSWalSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAA 108
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGL--SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 109 LAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLE--DFGWRIMFGIGM 186
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 187 IPLLLIPFIIRYLPESIQFLLSRNRQEEvdkilnrfqiefyakdethqapsniRKKNGFLTLFSKEYIKATLLFWITYIM 266
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEA-------------------------SSKSVLKLLKRVLKNPGLWLLLLAIFL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 267 GMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLN-ITAAIGALFAGAIADR-IGAKIVISISYLMAAICIGLLTIKPSVS 344
Cdd:cd06174 215 VNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFgLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 345 IIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLAA 424
Cdd:cd06174 295 LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
....
gi 447105862 425 ISVF 428
Cdd:cd06174 375 ILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-430 |
1.99e-21 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 95.33 E-value: 1.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSI 102
Cdd:COG2807 18 LLLLAIVLVALNLRPAITSVGPLLPEIRAD--LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 103 TMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKkRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMF 182
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 183 GIGMIPLLLIPFIIrylpesiqFLLSRNRqeevdkilnrfqiefyaKDETHQAPSNIRKKNGFltlfskeyiKATLLFWI 262
Cdd:COG2807 175 AVWALLALLALLLW--------LPLLRRR-----------------PAAAAAAPAAASLRSLW---------RSPLAWLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 263 TYIMGM--FLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGA-KIVISISYLMAAICIGLLTI 339
Cdd:COG2807 221 TLFFGLqsLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDrRPLLLLLGLLGLAGLLGLLL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 340 KPSvSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSL-GWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSF 418
Cdd:COG2807 301 APG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAA 379
|
410
....*....|..
gi 447105862 419 AGLLAAISVFFI 430
Cdd:COG2807 380 LAVLMLVAGLLA 391
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
26-430 |
2.06e-20 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 93.22 E-value: 2.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLleDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMG 105
Cdd:PRK03893 23 SAAWLGYLLDGFDFVLITLVLTEV--QGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 106 LAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIG 185
Cdd:PRK03893 101 ACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 186 MIPLLLIPFIIRYLPESIQFllsRNRQEEVDKILNRFQIEFYAKDETHQAPSNIRKKNGFLTLFSKEYIKATLLF----- 260
Cdd:PRK03893 181 ILPIIFALWLRKNLPEAEDW---KEKHAGKAPVRTMVDILYRGEHRIINILLTLAAAAALWFCFAGNLQNAAIVAvlgll 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 261 ----------------WITYIMGMFLIYG--LNTW-----LPQMMRQ-AGYPLGSSLSFLLMLNITAAIGALFAGAIADR 316
Cdd:PRK03893 258 caaifisfmvqssgkrWPTGVMLMVVVLFafLYSWpiqalLPTYLKTdLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDW 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 317 IGAKIVISISYLMAAICIGLLTIKPSVSIIYL--LIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIA 394
Cdd:PRK03893 338 LGTRKAYVCSLLISQLLIIPVFAIGGANVWVLglLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFTYNVGALGGAL 417
|
410 420 430
....*....|....*....|....*....|....*.
gi 447105862 395 GPILvGIIMTMQYDLAWNfyLFSFAGLLAAISVFFI 430
Cdd:PRK03893 418 APIL-GALIAQRLDLGTA--LASLSFSLTFVVILLI 450
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
24-429 |
8.33e-20 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 90.66 E-value: 8.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 24 VVFICWLAILADGYDLGIYGA----VLPKLLEDnswALSPAhAGTIASYALFGM-F----IGAILVGTITDLIGRKWTLI 94
Cdd:cd17369 3 VALASLVGTAIEWYDFFIYGTaaalVFNKLFFP---AVDPA-AGTLAAFATFGVgFlarpLGGVVFGHFGDRIGRKKTLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 95 CCLALFSITMGLAALAPSPELFGLW--------RFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLG- 165
Cdd:cd17369 79 LTLLLMGIATFLIGLLPTYAQIGILapillvllRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLAt 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 166 ---AILSMFMLEDF----GWRIMFgIGMIPLLLIPFIIRY-LPESIQFLlsrnRQEEVDKILNRFQIEFYAKDethqaps 237
Cdd:cd17369 159 gvfLLLSALLSDEAflswGWRIPF-LLSAVLVAVGLYIRLrLEETPVFR----RAKEAGQVVRAPLVEVLRRH------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 238 nirkkngfltlfSKEYIKATLLFWITYIM-GMFLIYGLnTWLPQmmrQAGYPLGSSLSFLLMLNITAAIGALFAGAIADR 316
Cdd:cd17369 227 ------------WRALLLAIGLRLAENVLfYLFTTFAL-SYATQ---TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 317 IGAKIVISISYLMAAICI----GLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRAT--SLGWGLGLGRV 390
Cdd:cd17369 291 VGRRPVYLAGALLAALFAfpffWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTgaSLGYQLGAILG 370
|
410 420 430
....*....|....*....|....*....|....*....
gi 447105862 391 GAIAgPILVGIIMTMQYDLAWNFYLFSFAGLLAAISVFF 429
Cdd:cd17369 371 GGFA-PLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
36-430 |
5.98e-19 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 88.48 E-value: 5.98e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 36 GYDLGIYGAVLPKLLEDNSWALSPAHAGTIASY---------ALFGMFIGAILVGTITDLIGRKWTLICCLALFSIT--- 103
Cdd:pfam00083 13 GYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSvlsglivsiFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGavl 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 104 MGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFML---EDFGWRI 180
Cdd:pfam00083 93 QGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNktsNSDGWRI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 181 MFGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILNRFQIEFYA-------KDETHQAPSniRKKNGFLTLFSKEY 253
Cdd:pfam00083 173 PLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVdreldeiKDSLEAGQE--AEKASWKELFSTKT 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 254 IKATLLFWITYIMGMFL--IYGLNTWLPQMMRQAGYPLGSSLSFLLM-LNITAAIGALFagaIADRIGAKIVISISYLMA 330
Cdd:pfam00083 251 RRQRLLIGVMLQIFQQLtgINAIFYYSTTIFENLGLSDSFLVTIIVGvVNFVFTFIAIF---LVDRFGRRPLLLLGAAGM 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 331 AICIGLLTI-----------KPSVSIIYLLIGLAGIGsVGITQILNAYVTQYFPSHIRATslgwGLGLGRVGAIAGPILV 399
Cdd:pfam00083 328 AICFVILGIvallgvsksdwAGIVAIVFIALFIAFFA-MGWGPVPWVIVSELFPLSVRSK----AMALATAANWLANFLI 402
|
410 420 430
....*....|....*....|....*....|.
gi 447105862 400 GIIMTMQYDLAWNFYLFSFAGLLAAISVFFI 430
Cdd:pfam00083 403 GFLFPIITDAIGLGYTFFIFAGLLVLFIIFV 433
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-430 |
1.92e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 83.39 E-value: 1.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 40 GIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW 119
Cdd:cd17474 16 SIVDPILPAIAEA--LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 120 RFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFmLEDFGWRIMFgigMIPLLLIPFIIryl 199
Cdd:cd17474 94 RALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPF---FLLAALIPVAF--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 200 peSIQFLLSRNRQEEVDKIlnrfqiefyaKDETHQAPSNIRKKNGFLTLFskeyikatllfwITYIMGMFLIYGLNTWLP 279
Cdd:cd17474 167 --LAILFLLPEPKEKAKSS----------SATKLRDLKKALRGRGLLTFL------------VSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 280 QMMRQAGY--PLGSSLSFLLMLnITAAIGALFAGAI-ADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIG 356
Cdd:cd17474 223 FLLELLYGisPIIIGLLFAGWS-VLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447105862 357 SVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMtMQYDLAWNFYLFSFAGLLAAISVFFI 430
Cdd:cd17474 302 LGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL-EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-430 |
1.45e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.05 E-value: 1.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 21 TKLVVFICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALF 100
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDA--FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 101 SITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIyALMFTGYPLGIVLGAILSMFML---EDFG 177
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLIllgLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 178 WRIMFGIGMIPLLLIPFIIRYLPesiqfllsrnrqeevdkilnrfqiefyAKDETHQAPSNIRKKNGFLTLFSKeyiKAT 257
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSK---------------------------LPEIEEEEEEAAGSAASLKSLLKN---PRL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 258 LLFWITYIMGMFLIYGLNTWLPQMMRQA-GYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGL 336
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 337 LTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHiRATSLGWGLGLGRVGAIAGPILVGIIMTMqYDLAWNFYLF 416
Cdd:COG0738 293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADA-FGLRAAFLVP 370
|
410
....*....|....
gi 447105862 417 SFAGLLAAISVFFI 430
Cdd:COG0738 371 LVCYLLILLLALAL 384
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
23-433 |
2.75e-16 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 80.31 E-value: 2.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGIYGAVLPKLLEDNSWA--LSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALF 100
Cdd:cd17358 2 LATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSlpLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 101 SITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKK-RQSFIYALMFTgYPLGIVLGAILSMFMledfGWR 179
Cdd:cd17358 82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNvRGALGSLNQLL-VNIGILLGYVLGSFL----PWR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 180 IMFGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILNRF-------QIEFYAKDETHQAPSNIRKKNGFLTLFSKE 252
Cdd:cd17358 157 TLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLrgkdadiSKEAAEIQEELAELEKEAKESSFSDLFQRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 253 YIKATLLfwityIMGMFL------IYGLNTWLPQMMRQAGYPLGSSLSFlLMLNITAAIGALFAGAIADRIGAKIVISIS 326
Cdd:cd17358 237 YLKPLVI-----GLGLMLfqqlsgINAVIFYASSIFDEAGSGLDPNTAT-IIIGVVQVVGTLVATLLVDRLGRRPLLLVS 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 327 YLMAAIC----------------IGLLTIKPSVSIIyLLIGLAGIGSVGITQILNAYVtqyFPSHIRatslgwGLGLGRV 390
Cdd:cd17358 311 AIGMGIGllalglyfylqehgalLSSVSWLPLVGLV-IYIISFSIGLGPLPWVIMSEI---FPAKIK------GLAGSLV 380
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 447105862 391 GAIAGPILVGIIMTMQY-DLAWN----FYLFS-FAGLLAAISVFFIP-TK 433
Cdd:cd17358 381 TLVNWLFAFIVTKTFPFlTLAWGasgtFWIFAgICGLALVFVLLFVPeTK 430
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
41-428 |
1.23e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 74.90 E-value: 1.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 41 IYGAVLPKLLED--NSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGL 118
Cdd:cd17478 10 FYQGFLPALLPLliAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 119 WRFIGGIGLGGVIPTASALTVEYSPKKRqSFIYALMFTGYPLGIVLGAILSMFMLEDFGwrimfGIGMIPLLLIPFIIry 198
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGGRR-GLAMSIFSVGGNLGFALGPLIAAALVALFG-----GLGLLILLIIPGLA-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 199 lpesIQFLLSRNRQEEVdkilnrfqiefYAKDETHQAPSNIRKKNGFLtlfskeyiKATLLFWITYIMGMFLIYGLNTWL 278
Cdd:cd17478 162 ----VALLLLRLRPLKK-----------PEAKKAAAKSSARSTLKGVW--------RALLLLLIIVFLRSWVLSSLTTFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 279 PQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVsIIYLLIGLAGIGSV 358
Cdd:cd17478 219 PFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI-WSYILLVLAGFLLF 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447105862 359 GITQILNAYVTQYFPSHIR-ATSLGWGLGLGrVGAIAGPILvGIIMTMqYDLAWNFYLFSFAGLLAAISVF 428
Cdd:cd17478 298 ASFPVTVVLAQELLPGNVGlASGLMMGLSFG-LGGIGAPVL-GALADA-FGLESVLLILALLPLLGALLAF 365
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
75-428 |
1.31e-14 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 75.10 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 75 IGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW--------RFIGGIGLGGVIPTASALTVEYSPKKR 146
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIGIAapllvllaRLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 147 QSFIYALMFTGYPLGIV----LGAILSMFM----LEDFGWRIMFGIGMIPLLLIPFIIRYLPESIQFlLSRNRQEEVDKI 218
Cdd:cd17368 135 RGFYTSWQSASQQVAIVagalVGYLLSLTLtaeaLAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAF-LERKARPTRREL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 219 LNRFqiefyakdethqaPSNIRK-KNGFLTLfskeyIKATLLFwitYIMGMFLIYGLNTWLpqmmrqaGYPLGSSLSFLL 297
Cdd:cd17368 214 FALL-------------ANNRRIiLLGMLLV-----AGSTVTF---YFTTVYTPTYAKTVL-------GLSARDSFLVTL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 298 MLNITAAIGALFAGAIADRIGAKIVISISYLMAAICI----GLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFP 373
Cdd:cd17368 266 LAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLypvfAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFP 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447105862 374 SHIRAT--SLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLF--SFAGLLAAISVF 428
Cdd:cd17368 346 VRVRSTgfSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMgaALLGLLATLMLR 404
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
67-430 |
2.14e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 74.23 E-value: 2.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 67 SYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSP-ELFGLWRFIGGIGLGGVIPTASALTVEYSPKK 145
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFER 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 146 RQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGI-GMIPLLLIPFIIrylpesiqfLLSRNRQEEVDKILnrfqi 224
Cdd:cd17355 125 RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVlALLALLVLVPVL---------LLLRRRPADLALRA----- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 225 efyAKDETHQAPSNIRKKngfltlfskeyIKATLLFWI---TYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNI 301
Cdd:cd17355 191 ---YDDASPASPGSTLKE-----------ALRSASFWLlalAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 302 TAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLA-GIGSVGITQILNAYVTQYFPSHIRATS 380
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGATVPLTAALAARYFGARSYGTL 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 447105862 381 LGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLAAISVFFI 430
Cdd:cd17355 337 FGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
64-407 |
4.56e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 73.36 E-value: 4.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 64 TIASYAL-FGMFIgaILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYS 142
Cdd:cd17321 36 VVNAYLLaFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 143 PKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIgMIPLLLIPFIirylpesiqfllsrnrqeevdkilnrf 222
Cdd:cd17321 114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI-NVPIGLVALL--------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 223 qiefyakdethqapsnirkkngfltlFSKEYIKATLlfwiTYIMGMFLIYGLNTWLPQMMrQAGYPLGSSLSFLLML--N 300
Cdd:cd17321 166 --------------------------LARTFSGAVL----AAFLLGAALGGLLFLLPLYL-QGVLGYSPLQAGLALLplA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 301 ITAAIGALFAGAIADRIGAKIVISISYLMAAI-CIGLLTIKPSVSIIYLLIGLA--GIGSVGITQILNAYVTQYFPSHIR 377
Cdd:cd17321 215 LAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVgLLLLALLGADSSVWLLLPGLVllGLGLGLFATPLTNAALSSVPKEKA 294
|
330 340 350
....*....|....*....|....*....|
gi 447105862 378 ATSLGWGLGLGRVGAIAGPILVGIIMTMQY 407
Cdd:cd17321 295 GAASGILNTARQLGGALGVALLGALLTAGL 324
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
30-431 |
5.52e-14 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 72.92 E-value: 5.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 30 LAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAAL 109
Cdd:cd17441 6 LAWMADAMEMMILSILAPQLHCE--WRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 110 APSPELFGLWRfIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPL 189
Cdd:cd17441 84 APIYSWILVLR-GLVGFGIGGVPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 190 LLIPFIIRYLPESIQFllsrnrqeevdkilnrfqiefyakdethqapsnirkkngfltlfskeyiKATLLFWITYIMGMF 269
Cdd:cd17441 163 LIFAVLCFWLPESARY-------------------------------------------------WTTILLWFIWFSNAF 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 270 LIYGLNTWLPQMMRQAGYPLGSSLSF-------------------LLMLNITAAIGALFAGAIADRIGAKIVISISYLMA 330
Cdd:cd17441 194 SYYGLVLLTTELFQAGDVCSGSSGKKvegkcsleceylttsdymdLLWTTLSEFPGLLVTLWIIDRFGRKKTMALCFFVF 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 331 AICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLA 410
Cdd:cd17441 274 SFCTLLLFSCVGRFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLT 353
|
410 420
....*....|....*....|.
gi 447105862 411 WNFYlfSFAGLLAAISVFFIP 431
Cdd:cd17441 354 LSVY--SGCCLLAAIASCFLP 372
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
26-283 |
1.88e-13 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 71.88 E-value: 1.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMG 105
Cdd:cd17438 2 FVLGLALMADGVEVFVVGFVLPSAEKD--MCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 106 LAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFG-------- 177
Cdd:cd17438 80 LSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtn 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 178 -----WRIMFGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILNRFQiefyakdethqaPSNIRKKNGFLTLFSKE 252
Cdd:cd17438 160 yhfhsWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIH------------DTNMRAKGTPEKVFTVS 227
|
250 260 270
....*....|....*....|....*....|...
gi 447105862 253 YIKA--TLLFWITYIMGMFLIYGLNTWLPQMMR 283
Cdd:cd17438 228 NIKRknTLFLAVVWFTMAFSYYGLTVWFPDMIR 260
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
58-429 |
2.95e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.70 E-value: 2.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 58 SPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASAL 137
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 138 TVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEvdk 217
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT--- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 218 ilnrfqiefyakdethQAPSNIRKKNGFLTlfskeyikATLLFWITYIMGMFLiyglnTWLPQMMRQAGYPLGSSlsFLL 297
Cdd:cd17489 186 ----------------RAFRRLVEKKVLPP--------ALILFLASIAYGAIS-----TFLPLYAAERGISNAGL--FFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 298 MLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIR 377
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 447105862 378 ATSLGWGLGLGRVGAIAGPILVGIIMT-MQYDlawnfYLFSFAGLLAAISVFF 429
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAElFGYR-----AMFLLAAVVVLLALVL 362
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
255-429 |
4.67e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 70.00 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 255 KATLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICI 334
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 335 GLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTmQYDLAWNFY 414
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFGWRWVFL 168
|
170
....*....|....*
gi 447105862 415 LFSFAGLLAAISVFF 429
Cdd:COG2814 169 VNAVLALLALLLLLR 183
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
62-425 |
1.43e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 68.79 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 62 AGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEY 141
Cdd:cd17329 37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 142 SPKKRQSFIYALMFTGYPLGIVLGAILSMFMLE-DFGWRIMFGIGMiPLLLIPFIIRYLPESIqfllsrnrqeevdkiln 220
Cdd:cd17329 117 TTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLySFRLLFLAAAVL-FLLAALVLLFLLPETR----------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 221 rfqiefyAKDETHQAPSNIRKKNGFLTLfskeyiKATLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLN 300
Cdd:cd17329 179 -------PKRRAAEKTEILRGYKIVLRD------RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 301 -ITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRAT 379
Cdd:cd17329 246 aLLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447105862 380 SLGWGLGLGRVGAIAGPILVGIIMTMQYDlAWNFYLFSFAGLLAAI 425
Cdd:cd17329 326 YMGFYALAWGLGRAIGPLVGGLLLDLLGP-GLPWLILAALGLIAAA 370
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
26-284 |
1.52e-12 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 69.62 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMG 105
Cdd:TIGR01299 170 FVLGLALMADGVEVFVVGFVLPSAEKD--LCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAF 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 106 LAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEY--SPKKRQSFIYALMFtgYPLGIVLGAILSMFMLEDFGWRIMFG 183
Cdd:TIGR01299 248 FSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFlaQEKRGEHLSWLCMF--WMIGGIYAAAMAWAIIPHYGWSFQMG 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 184 -------------IGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILN---------RFQIE----------FYAKDE 231
Cdd:TIGR01299 326 sayqfhswrvfviVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKlihdtnmraKGHPEkvfsvnhiktIHQEDE 405
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447105862 232 THQAPSN-----------IRKKNG-----FLTLFSKEYIKATLLFWITYIMGMFLIYGLNTWLPQMMRQ 284
Cdd:TIGR01299 406 LIEIESDtgtwyqrcfvrALSEGGgiwgnFLRCFNPEVREITIKLMGVWFTLSFGYYGLSVWFPDMIKH 474
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
75-431 |
1.74e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 75 IGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEY-SPKKRQSFI-YA 152
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYfEGEERAKMLgLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 153 LMFTGyplgivLGAILSMF---MLEDFGWRIMFGIGMIPLLLIPFIIRYLPESiqfllsrnrqeevdkilnrfqiefyaK 229
Cdd:cd17473 130 SAAMS------LGGVVFLLlggALAEIGWRAPFLVYLLALPVLILVLLFLPEP--------------------------A 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 230 DETHQAPSNIRKKNGFLTlfskeyIKATLLFWITYIMGMFLIYGLNTWLPQMMRQAGypLGSSLSFLLML---NITAAIG 306
Cdd:cd17473 178 RKSKSAASPGAATAAALP------WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG--GGSAALIGLALaiaSLAGAIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 307 ALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLG 386
Cdd:cd17473 250 ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447105862 387 LGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17473 330 AFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
39-339 |
2.20e-12 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 68.44 E-value: 2.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 39 LGIYGAVLPKLLEDNSWalspahaGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALF---SITMGLAALAPSPEL 115
Cdd:cd17357 35 VDRYGLNLSDSELDLLW-------SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLvvsSLLMFLSKSAKSPEL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 116 FGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSM-FML-EDFGWRIMFGIGMIPLLLIP 193
Cdd:cd17357 108 LIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLpSVLgTETLWPYLLFFPGIPALLQL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 194 FIIRYLPESIQFLL-SRNRQEEVDKILNRFQIEFYAKDETHQ------APSNIRKKNGFLTLFSKEYIKATLLFWITYIM 266
Cdd:cd17357 188 AALPFFPESPKFLLiSKGDEEEAEKSLKFLRGIEDDVDQELEeikkesEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVSA 267
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447105862 267 GMFL--IYGLNTWLPQMMRQAGY-PLGSSL--SFLLMLNItaaIGALFAGAIADRIGAKIVISISYLMAAICIGLLTI 339
Cdd:cd17357 268 SQQFsgINAIFFYSTFIFENAGFsPQLAEWanLGIGIVNV---LSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSV 342
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
226-431 |
2.71e-12 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 67.95 E-value: 2.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 226 FYAKDETHQAPSNIRKKNGFLTLFSKEYIK---ATLLFWITYIMGMFLIYglntwlpqMMRQAGYPLGSSLSFLLMLNIT 302
Cdd:cd17370 175 FVVKEYPRPPKLRKKSKKTSLKKLPKAFWLyllAVALFALGNFSFAFLIL--------RAQELGLSAALIPLLYALFNLV 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 303 AAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGsVGITQ-ILNAYVTQYFPSHIRATSL 381
Cdd:cd17370 247 YALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLY-MGAQEsIERAAVADLVPAELRGTAY 325
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 447105862 382 GW-GLGLGrVGAIAGPILVGIImtmqYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17370 326 GLfNTVVG-IGWLLASLIAGYL----WDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
75-387 |
2.97e-12 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 67.70 E-value: 2.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 75 IGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW--------RFIGGIGLGGVIPTASALTVEYSPKKR 146
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIGIWapiilllaRLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 147 Q----SFIYALMFTGYPLGIVLGAILSMFMLED----FGWRIMFGIGMIPLLLIPFIIRYLPESIQFLlsrnrqeevdki 218
Cdd:cd17367 135 RgfysSFQYVTLIGGQLLALGVLLVLQHTLGEDqmaaWGWRIPFLLGGVLAVVVLWLRRGLEETESFE------------ 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 219 lnrfqiefyakdethQAPSNIRKKNGFLTLFSKEYIKATLLFWITyIMGMFLIYGLNTWLPQMMRQ-AGYPLGSSLSFLL 297
Cdd:cd17367 203 ---------------AIAESNEASAGTLRELRRHPRELLLVVGLT-AGGTLAFYTWTTYLQKFLVNtAGFSKGDATWITT 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 298 MLNITAAIGALFAGAIADRIGAK-IVISISYLMAAICIGLLTI---KPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFP 373
Cdd:cd17367 267 AALLVFMLLQPLGGRLSDRIGRRpLLLFFGIGGTLATVPLLSAldhTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFP 346
|
330
....*....|....
gi 447105862 374 SHIRATSLGWGLGL 387
Cdd:cd17367 347 THVRALGVGLPYAL 360
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
70-431 |
3.66e-12 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 67.22 E-value: 3.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 70 LFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSF 149
Cdd:cd17317 35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 150 IYALMFTGYPLGIVLGAILSMFMLEdfgWR-IMFGIGMIPLLLIPFIirylpesiqFLLSRNrqeevdkilnrfqiefya 228
Cdd:cd17317 115 VGILFGLFWALGYMLLALLAYLIRD---WRwLQLAISLPGLLFLLLL---------WWLPRR------------------ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 229 kdethqapsnirkkngfltlfskeyikaTLLFWITYIMGMFLIYGLntwLPQMMRQAGYPLgssLSFLLMlNITAAIGAL 308
Cdd:cd17317 165 ----------------------------TIIVGLIWFVTSLVYYGL---SLNSSNLGGNLY---LNFFLS-GLVEIPAYF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 309 FAGAIADRIGAKIVISISYLMAAICIG----LLTIKPSVSIIYLLIGLAGIGSVgiTQILNAYVTQYFPSHIRATSLGWG 384
Cdd:cd17317 210 LALLLLDRLGRRWTLSGSLLLAGLACLvtalLPDDENTLALTLALVGKFAISAA--FSVIYLYTAELYPTVVRNTGVGLC 287
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 447105862 385 LGLGRVGAIAGPILVgiiMTMQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17317 288 STVARVGAILAPFIV---LLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
72-431 |
1.22e-11 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 65.39 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 72 GMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFiy 151
Cdd:cd17374 47 GLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRAL-- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 152 ALMFTGYPLGI---VLGAIlsMFMLEDfgWRIMFGIGMIPLLLIPFIIRYLPESIQFLlsrnrqeevdkilnrfqiefya 228
Cdd:cd17374 125 AITLTSCFFSIgqmLLAGL--AYAIRD--WRLLQLVVSVPFFLFFLYSWWLPKRTLIL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 229 kdethqapsnirkkngFLTLFskeyikATLLFWITYIMGMFLIyGLNTWLPQMMRQAGYPLGSSLSFLLMlnitaaigal 308
Cdd:cd17374 179 ----------------SFVWF------ANSFSYYGLSLDLQHL-GLNVFLLQFLFGAVEVPARCLALFLL---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 309 fagaiaDRIGAKIVISISYLMAAICIGLLTIKPS-VSIIYLLIGLAGIGSVGIT-QILNAYVTQYFPSHIRATSLGWGLG 386
Cdd:cd17374 226 ------NHMGRRISQAVLLLLAGLCILANIFVPQeMQTLRTVLAVLGKGSSAAAfTISYVYTAELFPTVLRQTGMGLNSM 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447105862 387 LGRVGAIAGPiLVGIIMTMQYDLAWNFYlFSFAgLLAAISVFFIP 431
Cdd:cd17374 300 FARIGGILAP-LIMLLGVYSPLLPMIIY-GVLP-ILAGLLALLLP 341
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
26-283 |
2.05e-11 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 65.59 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMG 105
Cdd:cd17363 2 FVLGLALMADGVEVFVVGFVLPSAEKD--MCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 106 LAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEY-SPKKRQSFIYAL-MFtgYPLGIVLGAILSMFMLEDFG------ 177
Cdd:cd17363 80 LSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFlAREKRGEHLSWLcMF--WMIGGLYASAMAWAIIPHYGwgfsmg 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 178 -------WRIMFGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILNRFQiefyakdethqaPSNIRKKNGFLTLFS 250
Cdd:cd17363 158 tayqfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVH------------DTNMRAKGHPERVFT 225
|
250 260 270
....*....|....*....|....*....|....*
gi 447105862 251 KEYIK--ATLLFWITYIMGMFLIYGLNTWLPQMMR 283
Cdd:cd17363 226 VSHIKrmNTLFLAIVWFTMSFSYYGLTVWFPDMIK 260
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
255-433 |
2.74e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.88 E-value: 2.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 255 KATLLFWITYIMGMFLIYGLNTWL-----PQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLM 329
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALwgpliPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 330 AAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHiRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDL 409
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161
|
170 180
....*....|....*....|....
gi 447105862 410 AWNFYLFSFAGLLAAISVFFIPTK 433
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSK 185
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
26-283 |
3.22e-11 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 65.05 E-value: 3.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMG 105
Cdd:cd17439 2 FVLGLALMADGVEVFVVGFVLPSAEKD--MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 106 LAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFG-- 183
Cdd:cd17439 80 FSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQMGsa 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 184 -----------IGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILNRFQiefyakdethqaPSNIRKKNGFLTLFSKE 252
Cdd:cd17439 160 yqfhswrvfvlVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVH------------DTNMRAKGHPERVFSVT 227
|
250 260 270
....*....|....*....|....*....|...
gi 447105862 253 YIK--ATLLFWITYIMGMFLIYGLNTWLPQMMR 283
Cdd:cd17439 228 HIKrrITLMMMAVWFTMSFSYYGLTVWFPDMIK 260
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
55-430 |
5.26e-11 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 63.71 E-value: 5.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 55 WALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRfIGGIGLGGVIPTA 134
Cdd:cd17372 29 WNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILR-CLVGLGLGGGPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 135 SALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPFIIRYLPesiqfllsrnrqee 214
Cdd:cd17372 108 ASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTP-------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 215 vdkilnrfqiefyakdethqapsnirkkngfltlfskeyiKATLLFWITYIMGMFLIYGLnTWLPQMMRQAGYPLGSSLS 294
Cdd:cd17372 174 ----------------------------------------KTTLLLWVIWFGNAFAYYGV-VLLTTELNNSHNVCGSKSD 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 295 F---------------------LLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLA 353
Cdd:cd17372 213 SdsgesptekqcrnsndvdyrdVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSPFILTVLLFGG 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447105862 354 GIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAwnFYLFSFAGLLAAISVFFI 430
Cdd:cd17372 293 RACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIA--LLLFSVVCLVSAICVCLL 367
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
40-424 |
8.96e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 62.96 E-value: 8.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 40 GIYGAVLPKLLEDNSwaLSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW 119
Cdd:cd17477 13 GLLLPLLSLRLEREG--VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 120 RFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPFIIRYL 199
Cdd:cd17477 91 RFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 200 PESiqfllsrnRQEEVDKIlnrfqiefyakdethqapsnirkknGFLTLFSkeyiKATLLFWITYIMGMFLIyGLNTWLP 279
Cdd:cd17477 171 AAP--------EIEEAESI-------------------------SLRRLLR----IAPLALLGAFVAGFLEG-AFYSLLP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 280 QMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSI-IYLLIGLAGIGSV 358
Cdd:cd17477 213 LYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLaLLVLLFLWGGAAG 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447105862 359 GITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLAA 424
Cdd:cd17477 293 PLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-431 |
9.82e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.98 E-value: 9.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 30 LAILADGYDLGIYGAVLPKLLEDnsWALSPAHAG-TIASYALFGMfIGAILVGTITDLIGRKWTLICCLALFSITMGLAA 108
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQRE--FGTSAAAVSwVLTAYLLVGA-VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 109 LAPSPELFGLWRFiGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWR----IMFGI 184
Cdd:cd17504 80 FAPNLPVLIAGRA-LQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRwifwTAAPV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 185 GMIPLLLIPFI-IRYLpesiqfllsrnrqeevdkilnrfqiefyakdethqapsniRKKNGFLTLFskeyikATLLFwit 263
Cdd:cd17504 159 AVLLAALVPLIdLRLL----------------------------------------RRRNVLLANI------TALLA--- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 264 yIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAA--IGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKP 341
Cdd:cd17504 190 -GFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVmlIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLH 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 342 -SVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQ-------------- 406
Cdd:cd17504 269 sSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYtvsitsggvptega 348
|
410 420
....*....|....*....|....*
gi 447105862 407 YDLAwnFYLFSFAGLLAAISVFFIP 431
Cdd:cd17504 349 YVLA--FLIGAALALAALLLSLLIP 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
57-427 |
1.84e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.26 E-value: 1.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 57 LSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASA 136
Cdd:cd17475 28 LSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 137 LTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPFIIrylpesiqFLLSRNRQEevd 216
Cdd:cd17475 108 AIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLF--------WLFYREPPA--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 217 kilnrfqiefyAKDETHQAPSNIRKKNGFLTlfskeyikaTLLFWITYIMGMFLI---YGLNT-WLPQMMRQAGYPLGSS 292
Cdd:cd17475 177 -----------ASAATESASTLLRSLKEVLR---------NRDVWLIAIAGALLVapqFALLTfLLLFLHDHLGLSVVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 293 LSFLLMLNITAAIGALFAGAIADRIGA----KIVISISYLMAAICIGLLTIKPSVSI--IYLLIGLAGIGSVGITQILNA 366
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVFGgrrrPVLVITAAIAAAALLVLSLLSPGTPLwlLVLLLILLGLFAIGWNGLYLT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447105862 367 YVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLAAISV 427
Cdd:cd17475 317 LVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
36-429 |
2.21e-10 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 61.81 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 36 GYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPEL 115
Cdd:cd17359 14 GYDTGVINGALPFLQTD--FNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 116 FGLWRFIGGIGLGGVIPTASALTVEYSPKKR--------QSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMI 187
Cdd:cd17359 92 FIIARIIGGLAVGGASALVPMYIAEVAPAEIrgrlvslnQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 188 PLLLIPFIIRYLPESIQFLLSRNRQeevdkilnrfqiefyakdethqapsnirkkngfltlfskeyikatlLFWITYIMG 267
Cdd:cd17359 172 PAILFLLGMLFIPESPRWLVSKGKP----------------------------------------------ILIIGIGLA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 268 MF-LIYGLNTWL---PQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAK-------IVISISYLMAAICIGL 336
Cdd:cd17359 206 IFqQFVGINVIFyygPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKpllligsIGMAISLLLIGTAFYF 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 337 LTIKPSVSIIYLLIGLAGIGSVGITQILNAYV--TQYFPSHIRatslGWGLGLGRVGAIAGPILVGI---IMTMQYDLAW 411
Cdd:cd17359 286 APGSQASGIVALVLILLFVAFFAMSWGPVTWVllSEIFPNRIR----GLAMGIAVFFLWIANFLVSLtfpILLAAFGLAF 361
|
410
....*....|....*...
gi 447105862 412 NFYLFSFAGLLAAISVFF 429
Cdd:cd17359 362 TFLIFAVICVLAFLFVWK 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
260-429 |
2.49e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 61.67 E-value: 2.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 260 FWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLN-ITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLT 338
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFsLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 339 IKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTmQYDLAWNFYLFSF 418
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGWRAAFLILAI 159
|
170
....*....|.
gi 447105862 419 AGLLAAISVFF 429
Cdd:pfam07690 160 LSLLAAVLLLL 170
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
36-202 |
2.57e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 61.82 E-value: 2.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 36 GYDLGIYGAVLPKLLEDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPEL 115
Cdd:cd17315 10 GYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 116 FGLWRFIGGIGLGGVIPTASALTVEYSPKKrqsfIYALMFTGYPLGIVLGAILSMFMLEDF------GWRIMFGIGMIPL 189
Cdd:cd17315 90 LIVGRFLLGLGVGLASVLVPLYISEIAPAK----IRGALGTLNQLMITFGILLAYLLGLALslsppgWWRLMFALAAVPA 165
|
170
....*....|...
gi 447105862 190 LLIPFIIRYLPES 202
Cdd:cd17315 166 LLQLLLMFFLPES 178
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
36-202 |
3.09e-10 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 61.52 E-value: 3.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 36 GYDLGIYGAVLPKLLED-NSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPE 114
Cdd:cd17360 10 GYDTGVISGALLYIKDDlGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 115 LFGLWRFIGGIGLGGVIPTASALTVEYSPKK---RQSFIYALMFTGYPL-GIVLGAILSMFmleDFGWRIMFGIGMIPLL 190
Cdd:cd17360 90 VLIVGRVLVGLGVGIASMTVPLYIAEAAPPRirgRLVTINVLFITGGQFvAYVINGAFSYL---PGGWRWMLGLAAVPAV 166
|
170
....*....|..
gi 447105862 191 LIPFIIRYLPES 202
Cdd:cd17360 167 LQFIGLLFLPES 178
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
31-431 |
3.64e-10 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 61.14 E-value: 3.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 31 AILADGYDLGIYGAVLP---KLLEDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLA 107
Cdd:cd17364 7 GFFTDAYDLFSISLVTKilgRLYYGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 108 ALAPSPELFG------LWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLE------- 174
Cdd:cd17364 87 ALSPGSTPLGvmgwliFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAifehplp 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 175 -------DFGWRIMFGIGMIP-LLLIPFIIRYLPESIQFLLsrnrqeevdkilnrFQIEFYAkdethqapsnirkkngfL 246
Cdd:cd17364 167 agtyhhaDLVWRIVLGLGAIPaLSVLYFRKHLLGTAGTWFL--------------LDIAFYG-----------------Q 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 247 TLFSKeyikatllfwiTYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLmlnitaaiGALFAGAIADRIGAK------ 320
Cdd:cd17364 216 NLFQS-----------TIISAIGFSKTMNAYQELFNIAVGQLIIALAGTVP--------GYWFTVFLIDRIGRKkiqmmg 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 321 -IVISISYLMAAICIGLLTIKPSVSI-IYLLIGLAG-IGSVGITQILNAYVtqyFPSHIRATSLGWGLGLGRVGAIAGPI 397
Cdd:cd17364 277 fFGMTIFLLILAGPYDHWKISTIGFFvLYGLTFFFSnFGPNTTTFIVPAEV---FPARVRSTCHGISAASGKIGAIVGSF 353
|
410 420 430
....*....|....*....|....*....|....
gi 447105862 398 LVGIIMTmQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17364 354 LFLSLTQ-NIGVRNVLIILAGVALLGIILTLLFP 386
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
75-202 |
4.58e-10 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 60.88 E-value: 4.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 75 IGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALM 154
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFP 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 447105862 155 FTGYPLGIVLGAILSMF---MLEDFGWRIMFGIGMIPLLLIPFIIRYLPES 202
Cdd:cd17437 127 EIFINIGILLGYVSNYAfsgLPLHVGWRLMLGVGAVPSLFLAIGVLAMPES 177
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
36-202 |
1.23e-09 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 59.67 E-value: 1.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 36 GYDLGIYGAVL-----PKLLEDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALA 110
Cdd:cd17362 10 GYDIGATSGALlsitsPALSGTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 111 PSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDF-GWRIMFGIGMIPL 189
Cdd:cd17362 90 PSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPA 169
|
170
....*....|...
gi 447105862 190 LLIPFIIRYLPES 202
Cdd:cd17362 170 LLLGIGMWFLPPS 182
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
26-283 |
1.39e-09 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 59.93 E-value: 1.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMG 105
Cdd:cd17440 2 FVLGMALMADGVEVFVVGFVLPSAETD--MCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 106 LAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFG-------- 177
Cdd:cd17440 80 LSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsa 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 178 -----WRIMFGIGMIPLLLIPFIIRYLPESIQFLLSRNRQEEVDKILNRFQiefyakdethqaPSNIRKKNGFLTLFSKE 252
Cdd:cd17440 160 yqfhsWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIH------------DTNMRARGQPEKVFTVN 227
|
250 260 270
....*....|....*....|....*....|...
gi 447105862 253 YIK--ATLLFWITYIMGMFLIYGLNTWLPQMMR 283
Cdd:cd17440 228 RIKkdNTIKLTIVWLTLSFGYYGLSVWFPDVIK 260
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
42-402 |
1.60e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 59.24 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 42 YGAVLPKLLEDNSWalSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRF 121
Cdd:cd06180 18 YTPLLPLMLAELGL--SYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 122 IGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLE-----DFGWRIMFGIGMIpLLLIPFII 196
Cdd:cd06180 96 LAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGgglswRAGWLALALLSAV-LLLLSFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 197 RYLPESiqfllsrnrqeevdkilnrfqiefyakDETHQAPSNIRKKNGFLTLfskEYIKATLLFWITYImgmflIYGlnT 276
Cdd:cd06180 175 LRRGPS---------------------------APTEASAAESAPGLNRPLW---RLALAYGLFGFGYI-----ITA--T 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 277 WLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIG 356
Cdd:cd06180 218 FLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGT 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 447105862 357 SVGITQILNAYVTQYFPSH----IRATSLGWGlglgrVGAIAGPILVGII 402
Cdd:cd06180 298 FMAITALVMALARELAPPAapraLALMTASFG-----VGQILGPLLAGWL 342
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
57-429 |
1.89e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 59.16 E-value: 1.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 57 LSPAHAGTIASYALFGMFIGA---------ILVGTITDLIGRKWTLICCLALFSITMGL-AALAPSPELFGLWRFIGGIG 126
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAygisqmllrIPLGILSDRIGKRKLFIIIGLLFTVLASLiMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 127 LGGVIpTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRImfgigmipllliPFIIRYLPESIQFL 206
Cdd:cd17490 99 AATWV-SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRA------------PFLLAALAGVLGFI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 207 LSRNRQEEvdkilnrfqiefyaKDETHQAPSNIRK-----KNGFLTLFSkeyIKATLLFWITYIMGMfliyglnTWLPQM 281
Cdd:cd17490 166 LSLFIKEE--------------RREKKPVLTELKEllsvlKDKKLLFFS---LLAILQQMITFSTTF-------GFTPLI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 282 MRQAGYPlGSSLSFLLMLN-ITAAIGALFAGAIA-DRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVG 359
Cdd:cd17490 222 AKQLGAS-SFQLGLLSIIYlLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGI 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 360 ITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMqYDLAWNFYLFSFAGLLAAISVFF 429
Cdd:cd17490 301 LFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEA-FGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
269-431 |
3.14e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 58.21 E-value: 3.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 269 FLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYL 348
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 349 LIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTM-QYDLAWNFYLFSFAGLLAAISV 427
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAAALALLAAILL 169
|
....
gi 447105862 428 FFIP 431
Cdd:cd06174 170 LLVV 173
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
58-402 |
6.76e-09 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 57.47 E-value: 6.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 58 SPAHAGTIASYAL-FGMFIGAIL---VGTITDLIGRK--WTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGL--GG 129
Cdd:COG2270 46 DPAAATALWGYALaIAGLLVALLapvLGAIADRSGRKkpFLAFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGfeGS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 130 VIPTASALtVEYSPKKRQSFIYALMF-TGYPLGIVLGAI-LSMFML-EDFGWR--------------IMFGIGMIPLLLi 192
Cdd:COG2270 126 LVFYNAFL-PDIATPEEIGRVSGLGWaLGYLGGVLLLLInLALFLKpEAFGLPdageavrisflltaLWWLLFALPLFL- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 193 pfiirYLPESiqfllsrnrqeevdkilnrfqiefyAKDETHQAPSNIRkkNGFLTLFS-----KEYiKATLLFWITYimg 267
Cdd:COG2270 204 -----FLPER-------------------------PRPGPAPPRGAVR--AGFRELRRtlrelRRY-RDLLRFLLAY--- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 268 MFLIYGLNTwlpqMMRQAGYpLGSS---------LSFLLMLNITAAIGALFAGAIADRIGAKIVISIS-YLMAAICIGLL 337
Cdd:COG2270 248 FFYRDGVQT----VIAFAGI-YAAGvlgfsttelIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSlVIWIVVCLAAY 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447105862 338 TIkPSVSIIYLLIGLAGIgSVGITQILN-AYVTQYFPSHIRATSLG-WGLgLGRVGAIAGPILVGII 402
Cdd:COG2270 323 FL-TTALAFWILGLLIGL-VMGGIQALSrSLLARLIPPGREAEFFGlYAL-SGKAASFLGPLLFGLV 386
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
301-431 |
3.60e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 3.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 301 ITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATS 380
Cdd:cd17489 42 LAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEG 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 447105862 381 LGWgLGLGRVGAIA-GPILvGIIMTMQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17489 122 IGY-YGLATTLAMAlGPAL-GLFLYQHLGFAVLFIVAAVLALLALLLVFLVK 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
40-430 |
5.94e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 5.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 40 GIYGAVLPKLLEDNsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKW-----TLICCLALFSITMGLAALAPSPE 114
Cdd:COG2211 27 GLLSAYLLYFYTDV-LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 115 ------LFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQ-SFIYALMFTGYPLGIVLGAILSMFMLEDF------GWRIM 181
Cdd:COG2211 106 ptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 182 FGIGMIpLLLIPFIIRYlpesiqfllsrnrqeevdkilnrfqieFYAKDETHQAPSNIRKKNGFLTLFSkeyIKATLLFW 261
Cdd:COG2211 186 ALIFAV-LGLLAFLLTF---------------------------FGTKERPVPEEEKVSLKESLKALLK---NRPFLLLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 262 ITYIMGMFLIYGLNTWLPQMMRQA-GYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAI-CIGLLTI 339
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALgLLLLFFL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 340 KP-SVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRAT------------SLGWGLGLGRVGAIAGPILV------G 400
Cdd:COG2211 315 GPgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglyfgifTFAIKLGQALAGALAGLLLAlfgyvaG 394
|
410 420 430
....*....|....*....|....*....|
gi 447105862 401 IIMTMQYDLAWNFYLFSFAGLLAAISVFFI 430
Cdd:COG2211 395 AAQSPSALTGIRLLFFLLPAVLLLLAALLL 424
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
300-431 |
6.27e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 6.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 300 NITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRAT 379
Cdd:cd17325 41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 447105862 380 SLGWGLGLGRVGAIAGPILVGIImTMQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17325 121 AMGIFSSAIGLGFLIGPLLGGLL-ADALGYRAPFLVCAALALLALVLALLLL 171
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
254-431 |
7.00e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.66 E-value: 7.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 254 IKATLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAIC 333
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 334 IGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMqYDLAWNF 413
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA-LGWRWIF 171
|
170
....*....|....*...
gi 447105862 414 YLFSFAGLLAAISVFFIP 431
Cdd:COG0477 172 LINAPLGLLALVLRLRLP 189
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-430 |
1.32e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 58 SPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW-----RFIGGIGLGGVIP 132
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWlllvlAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 133 TASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPFIIRYLPesiqfllsrnrq 212
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIR------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 213 eevdkilnrfqiefYAKDETHQAPSNIRKKNGFLTLFSKEYIKATLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSS 292
Cdd:cd06173 180 --------------RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 293 LSFLL-MLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQY 371
Cdd:cd06173 246 YGLLLaAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447105862 372 FPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMqYDLAWNFYLFSFAGLLAAISVFFI 430
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADA-LGLSAVFLLAGALLLLAALLLLLL 383
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
278-431 |
3.21e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.18 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 278 LPQMMRQAGYPlGSSLSFLLML-NITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIG 356
Cdd:COG2807 41 LPEIRADLGLS-ATQAGLLTTLpLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447105862 357 SVGITQILNAYVTQYFPSHI-RATSLgWGLGLGrVGAIAGPILVGIIMTMqydLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:COG2807 120 IAVGNVLLPGLIKRWFPDRVgLMTGL-YTAAMG-LGAALAAGLTVPLAAA---LGWRGALAVWALLALLALLLWLP 190
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
262-432 |
4.91e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 4.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 262 ITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKP 341
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 342 SVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLG-WGLGLGrVGAIAGPILVGIIMtmqyDLAWNFYLFSFAG 420
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGlWGAVVG-IGAALGPLLGGLLL----ELFGWRWIFLINV 157
|
170
....*....|..
gi 447105862 421 LLAAISVFFIPT 432
Cdd:cd17321 158 PIGLVALLLART 169
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
64-430 |
5.28e-07 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 51.46 E-value: 5.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 64 TIASYALfGMFIGAILVGTITDLIGRKWTLICClALFSIT----MGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTV 139
Cdd:cd17432 55 TVSIFPL-GGLFGSLLVGPLVIRLGRKGTLLLN-NIFAIVaailMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 140 EYSPKKRQSFI---YALMFTgypLGIVLGAILSMFML--EDFGWRIMFGIGMIPLLLIPFIIRYLPESIQFLL-SRNRQE 213
Cdd:cd17432 133 ESAPKNLRGAVglvPAIFIT---LGILLGQVLGLRELlgNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLiEKGDEE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 214 EVDKILNRF------QIEFYAKDETHQAPSNIRKKNgFLTLFSKEYIKATLLFWITYIMGMFLIyGLNT---WLPQMMRQ 284
Cdd:cd17432 210 AARKALQRLrgkedvDDEMEEMLEEQRAEKGVGTVS-VLELFRDRSVRWQLISIIVLMAGQQLC-GINAiyfYADSIFLE 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 285 AGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIK----------PSVSIIYLLIGLAG 354
Cdd:cd17432 288 AGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVAlslqntvswmPYLSIVCIFAYIAS 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 355 --IGSVGITQILnayVTQYF------PSHIRATSLGWgLGLGRVGAIAGPILVGIimtmqydLAWNFYLFSFAGLLAAIS 426
Cdd:cd17432 368 fgIGPAGVPFIL---TTEIFdqssrpAAFMVAGSLNW-LSNFLVGLLFPFIQEGL-------GAYCFLVFAVICLLTAIY 436
|
....
gi 447105862 427 VFFI 430
Cdd:cd17432 437 IFFV 440
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
29-429 |
8.25e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 50.65 E-value: 8.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 29 WLAILADGYDLGIYGAVLPKLLED-NSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLA 107
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREfNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 108 ALAPSPELFGLWRFiGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGI-GM 186
Cdd:cd17330 82 GLSRNLWLLFLARF-LDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVaAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 187 IPLLLIPFIIRYLPESIQFLLsrnrqeevdkilnrfqiefyakdethqapsnirkkngfltlfskeyikATLLFWITYIM 266
Cdd:cd17330 161 LALLNLVLVLFFLPPLRRLLL------------------------------------------------VYFLIALAFAG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 267 gmfLIYGLNTWLPQMMRQAGYPLGssLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSII 346
Cdd:cd17330 193 ---LESVFSLFLKDRFGFSPSQIG--LLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 347 YLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIImtmqYDLAWNFYLFSFAGLLAAIS 426
Cdd:cd17330 268 VLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL----YSFLGPGVPFLLAAGLLLIA 343
|
...
gi 447105862 427 VFF 429
Cdd:cd17330 344 LFL 346
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
53-430 |
9.58e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 50.65 E-value: 9.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 53 NSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIP 132
Cdd:cd17320 27 RDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 133 TASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWR----IMFGIGMIPLLLipfIIRYLPESiqfLLS 208
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRaifvFLALLGLLLLLL---VLLFLPET---LPE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 209 RNRQEEVDKILnrfqiefyakdethqapsnirkKNGFLTLFSKEYIKATLLFWITyiMGMFLIYglNTWLPQMMRQAGYP 288
Cdd:cd17320 181 EKRKPLLSSLL----------------------RAYKRVLKNRRFLGYALALGLS--FAGLFAY--LAAAPFIYIEQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 289 LGSSLSFLLMLNITAAI-GALFAGAIADRIGAK---IVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGI-GSVGIT-Q 362
Cdd:cd17320 235 SPAQFGLLFALNAIALIlGSLLNGRLVRRFGPRrllRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIfFGFGLIfP 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447105862 363 ILNAYVTQYFPSHI-RATSLgwgLGLGRVGAIAgpILVGIIMTMQYDLAWNFYLFSFAGLLAAISVFFI 430
Cdd:cd17320 315 NATSLALEPFPHVAgTASAL---LGFLQFLIGA--LAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
257-430 |
1.14e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.29 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 257 TLLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLM--LNITAAIGALFAGAIADRIGAKIVISISYLMAAICI 334
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFaaGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 335 GLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGpILVGIIMTMQYDLAWNFY 414
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA-ALVASLLIPLLSGDWGWR 159
|
170
....*....|....*.
gi 447105862 415 LFSFAGLLAAISVFFI 430
Cdd:cd17316 160 ILFLIGALPALLALLL 175
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
256-430 |
1.63e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 49.93 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 256 ATLLFWITYIMGMFLIY----GLNTWLPQMMRQAGYPLGSSL-SFLLMLN-ITAAIGALFAGAIADRIGAKIVISISYLM 329
Cdd:cd17313 241 LVIFFWWIAFFPFELFFtdymGEEVYHGTSAASSHYGAGVRMgAWGLLIFsLAFLIFSLPIGKLGKKIGRKKVYLIGLVL 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 330 AAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRatSLGWGLGLGRVGAIAGPILVGIIMTMQYDL 409
Cdd:cd17313 321 FAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGR--GQGTDTGLLNLAISLAQILVSLLAGPIIDV 398
|
170 180
....*....|....*....|.
gi 447105862 410 AWNFYLFSFAGLLAAISVFFI 430
Cdd:cd17313 399 KGYGTVFPVAAVASFLSLVGA 419
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
23-221 |
1.82e-06 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 50.03 E-value: 1.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGI-------------------YGAVLPKLLEDNSWALSpahagtIASYALFGMfIGAILVGTI 83
Cdd:cd17431 1 FAVFVAVLGSLQFGYNTGVinapqkvieefynktlgdrYGEPISPETLTTLWSLS------VAIFSVGGM-IGSFSVGLF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 84 TDLIGRKWTLIC--CLALF-SITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPL 160
Cdd:cd17431 74 VNRFGRRNSMLYnnLLAFAgAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVV 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447105862 161 GIVLGAILSM--FMLEDFGWRIMFGIGMIPLLLIPFIIRYLPESIQFLLS-RNRQEEVDKILNR 221
Cdd:cd17431 154 GILISQIFGLefILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLInRNEEEEAKSVLKK 217
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
65-202 |
2.53e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.87 E-value: 2.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 65 IASYALfGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPK 144
Cdd:TIGR00880 4 LAGYAL-GQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 447105862 145 KRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPF-IIRYLPES 202
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIlLAFLLPET 141
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
69-404 |
4.63e-06 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 48.57 E-value: 4.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 69 ALFGMFIGAILVGTITDLIGRK-------WTLICCLALFSITMGLAALAPSPELFgLWRFIGGIGLGGVIPTASALTVEY 141
Cdd:TIGR00887 65 ASIGTLAGQLFFGWLADKLGRKrvygmelIIMIIATVASGLSPGSSPKSVMATLC-FWRFWLGVGIGGDYPLSAIITSEF 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 142 SPKKRQSFIYALMFTGYPLGIVLGAILSMFMLE-----------------------DFGWRIMFGIGMIPLLLIPFIIRY 198
Cdd:TIGR00887 144 ATKKWRGAMMAAVFAMQGFGILAGAIVALIVLAgfkhsleaaadeasctgscvpavDYMWRILIGFGAVPALLALYFRLT 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 199 LPESI--QFLLSRNRQEEVDKILNRFQIEFYAKDETHQAPSN---IRKKN--GFLTLFSK-EYIKATLLFWITYIMGMFL 270
Cdd:TIGR00887 224 IPETPryTADVAKDVEQAASDMSAVLQVKIEAEPDEVEKASTaveVPKASwsDFFTHFFKwRHGKHLLGTAGSWFLLDIA 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 271 IYGLNTWLPQMMRQAGY-PLGSSLSFLLMLNITA-----------AIGALFAGAIADRIGAKIV-----ISISYLMAAIC 333
Cdd:TIGR00887 304 FYGVNLNQKVILSAIGYsPPAATNNAYEELYKTAvgnliialagtVPGYWVTVFLVDIIGRKPIqlmgfFILTVLFFVLG 383
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447105862 334 IGLLTIKPS--VSIIYLLIGLAGIGSVGITQILNAYVtqyFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMT 404
Cdd:TIGR00887 384 FAYNHLSTHgfLAIYVLAQFFANFGPNATTFIVPGEV---FPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQ 453
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
79-356 |
4.85e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 79 LVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGY 158
Cdd:cd17503 50 LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 159 PLGIVLGAILSMFMLEDFGWRIMF----GIGMIPLLLIPFIirylpeSIQFLLSRNrqeevdkilnrfqiefyakdethq 234
Cdd:cd17503 130 LLAPAIGPTLGGWLTDNLSWRWIFyinlPIGILALLLAPLL------DLRLFKDRN------------------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 235 apsnirkkngfLTLFSkeyikatllfwITYIMGMFLIYGLNTWLPQMMrQAGYPLGSSLSFLLML--NITAAIGALFAGA 312
Cdd:cd17503 180 -----------FTLGL-----------LLSFLLGLGLFGAMFLLPLYL-QNVLGYSAFESGLVLApgGLASAILSPLVGR 236
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 447105862 313 IADRIGAKIVISISYLMAAIC---IGLLTIKPSVSIIYLLIGLAGIG 356
Cdd:cd17503 237 LLDKFGPRLLLLAGLLLLALGtllLAFLTPDTSLWLIILPLFIRGLG 283
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
42-402 |
6.83e-06 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 47.75 E-value: 6.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 42 YGAVLPKLLEDNSWalSPAHAGTIASYALFGMFIGAIL--VGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW 119
Cdd:pfam06779 12 YTPILPVMIAEGQF--SLSQAGLLAAANYAGYLAGALLasFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 120 RFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDF--GWRIMFGIGMIPLLLIPFIIR 197
Cdd:pfam06779 90 RFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGlgGSSLWYGAGVLSAVLTLAVFP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 198 YLPESiqfllsrnrqeevdkilnrfqiefYAKDETHQAPSNIRKKNGFLTLfskEYIKATLLFWITYIMGMfliyglnTW 277
Cdd:pfam06779 170 LLPRR------------------------APRHASAPAPAAKPLQRSLPLW---ILTLAYGLAGFGYIITA-------TF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 278 LPQMMRQAGYplGSSLSFLL--MLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGI 355
Cdd:pfam06779 216 LPAMARDGFG--GPAAAALFwsLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGG 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 447105862 356 GSVGITQILNAYVTQYFPSHIRATSLGWGLGLGrVGAIAGPILVGII 402
Cdd:pfam06779 294 TFMAITSLVMQLARELAPPAPRRLLGLMTASFG-IGQILGPLLASLL 339
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
258-430 |
8.64e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.60 E-value: 8.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 258 LLFWITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLL 337
Cdd:cd17353 217 LLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 338 TIKPSVSIIYLL-IGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGiimtmQYDLAWNF-YL 415
Cdd:cd17353 297 PFIGSVAVLFVLgVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-----YVLYTGGYnAA 371
|
170
....*....|....*
gi 447105862 416 FSFAGLLAAISVFFI 430
Cdd:cd17353 372 FIIAAALSLVALALA 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-164 |
1.01e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 1 MQPSAPPHLESTKTIFSNSITKLVVFICWLAILADGYDLGIYGAVLPKLLEDNSwALSPAHAGTIASYALFGMFIGAILV 80
Cdd:COG2814 185 LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLA 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 81 GTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPL 160
Cdd:COG2814 264 GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
....
gi 447105862 161 GIVL 164
Cdd:COG2814 344 GGPL 347
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-196 |
1.06e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 12 TKTIFSNSITKLVVFICWLAILAdgydlGIYGAVLPKLLEDNsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKW 91
Cdd:cd06173 202 RYLRRSPLLRLLLLALALFALLG-----GALTVLLPLLAKEV-LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 92 TLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMF 171
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
170 180
....*....|....*....|....*
gi 447105862 172 MLEDFGWRIMFGIGMIPLLLIPFII 196
Cdd:cd06173 356 LADALGLSAVFLLAGALLLLAALLL 380
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
44-402 |
1.35e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.99 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 44 AVLPKLLEdnSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPS-PELFGLWRFI 122
Cdd:TIGR00881 16 LAMPYLVE--EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSlWVMAALWALN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 123 GGIGLGGVIPTASALTVEYSPKKRQSFiYALMFTGYPLGIVLGAILSMF-MLEDFGWRIMFGIGMIPLLLIPFIIrylpe 201
Cdd:TIGR00881 94 GIFQGMGWPPCGRTVTKWFSRSERGTW-VSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLIC----- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 202 siqFLLSRNR-----QEEVDKILNRfqiefYAKDETHQAPSNIRKKNGFLT--LFSKEYIkatlLFWITYIMGMFLIYGL 274
Cdd:TIGR00881 168 ---FLLLRDSpqscgLPPAEEMPNE-----EPDGDAEKKEEELTKKQIFLQyvLLNKVLW----YISLGYVFVYVVRTGI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 275 NTWLPQMMRQA-GYPLGSSLSFLLMLNITAAIGALFAGAIADRI--GAKIVISISYlMAAICIGLLTI-------KPSVS 344
Cdd:TIGR00881 236 LDWSPLYLTQEkGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFF-MALIIVSLLVYwlnpaanPLMDL 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447105862 345 IIYLLIGLAGIGSVGITQILnayVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGII 402
Cdd:TIGR00881 315 ICLFALGFLVYGPQMLIGVI---ASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
262-427 |
2.69e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.11 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 262 ITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKP 341
Cdd:cd17355 10 LILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 342 SVSIIYLLIGLAGIGSVG-ITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGiIMTMQYDLAWNFYLFSFAG 420
Cdd:cd17355 90 SLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGA-ALIEAFGWRTALLVLALLA 168
|
....*..
gi 447105862 421 LLAAISV 427
Cdd:cd17355 169 LLVLVPV 175
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
245-428 |
3.68e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.73 E-value: 3.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 245 FLTLFSKEYIKATLLFWITYIMGMFLIYGLNTWLPQMMRQ-AGYPLGSSLSFLLMLNITAAIGALFAGAIADRIG----A 319
Cdd:cd17312 173 ILFFFLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEvKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFggrrA 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 320 KIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSH-IRATSLGWGLGLGRVGAIAGPIL 398
Cdd:cd17312 253 PIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLP 332
|
170 180 190
....*....|....*....|....*....|
gi 447105862 399 VGIImTMQYDLAWNFYLFSFAGLLAAISVF 428
Cdd:cd17312 333 LGYI-IDHYGWSTVFYFLISAALLSVLLLL 361
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
35-205 |
4.53e-05 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 45.49 E-value: 4.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 35 DGYDLGIYGAVLPKLLEDNSW-ALSPAhAGTIASYALFG---MF--IGAILVGTITDLIGRKWTLICCLALFSITMGLAA 108
Cdd:PRK09952 34 DWYDFLLYGITAALVFNREFFpQVSPA-MGTLAAFATFGvgfLFrpLGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 109 LAPSPELFGLW--------RFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLG----AILSMFMLED- 175
Cdd:PRK09952 113 LLPSFSTIGWWapvllvtlRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLStglvSLISMMTTDEq 192
|
170 180 190
....*....|....*....|....*....|....
gi 447105862 176 ---FGWRIMFgIGMIPLLLIPFIIRY-LPESIQF 205
Cdd:PRK09952 193 flsWGWRIPF-LFSIVLVLIALWVRNgMEESAEF 225
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
70-193 |
6.52e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 44.88 E-value: 6.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 70 LFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSF 149
Cdd:PRK11043 51 LAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANR 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 447105862 150 IYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGI--GMIPLLLIP 193
Cdd:PRK11043 131 VFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATlfAITLLLILP 176
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
23-382 |
7.34e-05 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 44.87 E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGIYGAVLPKL--LEDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALF 100
Cdd:cd17433 2 LATFAAVLGPLSFGFVLGYSSPAIPSLqrIADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 101 SITMGLAALAPSpelfgLWRFIGGIGLGGVIPTASALTVE-YSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWR 179
Cdd:cd17433 82 IAGFTVITAAQN-----VWMLYVGRLLTGLASGVTSLVVPvYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDWR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 180 IMFGIGMIPLLLIPFIIRYLPESIQFLLSRN-RQEEVDKILNRFQIEFYAKDETHQAPSNIRKKNGFLTL-------FSK 251
Cdd:cd17433 157 WLAVLGSIPPTLMLLLMCFMPETPRFLLTQHrRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLallkqpgIYK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 252 EYIKATLLFWITYIMGmflIYGLNTWLPQMMRQAGYPLGSSLSFllmlnITAAIGALF---AGAIADRIGAKIVISISYL 328
Cdd:cd17433 237 PLIIGVSLMAFQQLTG---INAVMFYAETIFEEAKFKDSSVASV-----IVAAIQVLFtavAALIMDRAGRKVLLVLSGV 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447105862 329 MAAICIGLLTIKPSVSIIYLLIGLAgigsVGITQILNAYVTQYFPSHIRATSLG 382
Cdd:cd17433 309 VMVFSTAAFGWLAVGSMGFFIAGFA----VGWGPIPWLVMSEIFPLHVRGVASG 358
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
36-210 |
7.57e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 44.79 E-value: 7.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 36 GYDLGIYGAVLPKLleDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPEL 115
Cdd:cd17435 14 GYELGIISGALLQL--RTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 116 FGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILS-MFMLEDFGWRIMFGIGMIPLLLIPF 194
Cdd:cd17435 92 LIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNyAFANVSNGWKYMFGLVIPLAALQAI 171
|
170
....*....|....*.
gi 447105862 195 IIRYLPESIQFLLSRN 210
Cdd:cd17435 172 AMYFLPPSPRFLVMKD 187
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
301-431 |
8.05e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 8.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 301 ITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTI-----KPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSH 375
Cdd:cd06173 45 LPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKE 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 447105862 376 IRATSLGWGLGLGRVGAIAGPILVGIIMTmQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd06173 125 QLVRANALNSLATQLARIIGPALGGLLVA-LLGPGGAFAINALSFLLSALLLLFIR 179
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
73-199 |
1.04e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.12 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 73 MFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYA 152
Cdd:cd17489 240 LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANG 319
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447105862 153 LMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPFIIRYL 199
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
89-415 |
1.06e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 89 RKWtLICCLALFSITMGLAALAPS-PELFGLwRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAI 167
Cdd:cd17327 71 SKW-LSVFIVLWGLLTLLTAAVKNfGGLIAL-RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 168 LSMFMLED------FGWRIMFGI-GMIPLLLIPFIIRYLPEsiqfllsrnrqeevdkilNRFQIEFYAKDETHQAPSNIR 240
Cdd:cd17327 149 LAYGVFKIlgvgglAGWRWLFIIeGLITIIIGLVIFFWLPD------------------NPSKAWFLTEEEKELAVERLR 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 241 KKNGFL--TLFSKEYIKATLLFWITYIMGMFLI------YGLNTWLPQMMRQAGYplgSSLSFLLMLNITAAIGA---LF 309
Cdd:cd17327 211 ANQTGKgdQKFKWKQIKEAFKDPRTWLLFLFFFcsqitnNGISNFLPLILKSLGF---YSLQTNLLSVPIGALGAvslLI 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 310 AGAIADRIGAK-IVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHI-RATSLGWGLGL 387
Cdd:cd17327 288 AALLSDRFKKRgLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTkRATVLAIMLIF 367
|
330 340
....*....|....*....|....*...
gi 447105862 388 GRVGAIAGPILVGIIMTMQYDLAWNFYL 415
Cdd:cd17327 368 YNVGNIVAPQIFRAGDAPRYIPGNIALL 395
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
305-433 |
1.11e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 44.14 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 305 IGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIgsVGITQ-ILNAYVTQYFPSHIRATSLGW 383
Cdd:cd17390 46 FSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI--FKHTQsLCKAYLSDLVSEQERSRVLGR 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 447105862 384 GLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLAAISVFFIPTK 433
Cdd:cd17390 124 FNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLLSK 173
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
258-429 |
1.15e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 258 LLFWITYIMGM--FLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRI-GAKIVISISYLMAAICI 334
Cdd:cd17339 197 LAWQVTLFMGLqsLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLkNQRPIVVLLAVLFIIGV 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 335 GLLTIKPSVSIIYLLIgLAGIGSVGITQILNAYVTQYFPSHIRATSL-GWGLGLGRVGAIAGPILVGIIMTMQYDLAWNF 413
Cdd:cd17339 277 LGLLFAPTALALLWAV-LLGLGGGAAFSLALTLISLRSSDPAEAAALsGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPL 355
|
170
....*....|....*.
gi 447105862 414 YLFSFAGLLAAISVFF 429
Cdd:cd17339 356 VLLLALTVLQLVAGLG 371
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-429 |
1.40e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 62 AGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPS-PELFGLWRFIGGIGLGGviPTASALTVE 140
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNvWQLLILRLLQGVFSGYV--PNATALIAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 141 YSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIgMIPLLLIPFIIrylpeSIQFLLSRNRQEEVDKILN 220
Cdd:cd17391 116 QTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI-TGGLLFLAFLL-----TLFFVKEDFKPVEKKKMVS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 221 RFQIEFYAKDethqapsnirkKNGFLTLFSKEYIKATLLFWITYIMGMFlIYGLNTWLPQMMRQAGYPLGSSlsfllmlN 300
Cdd:cd17391 190 TKEVWNSVPN-----------PSLLISLFVTTFIIQLANQSIEPILTLY-IRQLMGDASNLAFISGLVFSAT-------G 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 301 ITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATS 380
Cdd:cd17391 251 VSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRI 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 447105862 381 LGWGLGLGRVGAIAGPILVGIImTMQYDLAWNFYLFSFAGLLAAISVFF 429
Cdd:cd17391 331 FGYNQSFQYLGNVAGPLLGSAI-AAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
28-402 |
1.41e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 28 CWLAILADGYDLGIYGAVLPKLLEdnSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLA 107
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEE--AFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 108 ALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKrQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMI 187
Cdd:cd17333 79 FATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 188 PLLLIPFIIRYLPESIQFLLSRNRQEEVDKILnrfqiefyakdethqapsnirkkngfLTLFSKEYIKATLLFWITYIMG 267
Cdd:cd17333 158 LIYLLLAILILLTLFPELPSARNPQQSVGAFS--------------------------ASASRLLRNPSIILGALALFLY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 268 MFLIYGLNTWLPQ-MMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAK--IVISISYLMAAICIGLLTIKPSVS 344
Cdd:cd17333 212 VGAETAFSSWVPSyLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHtlLVLSGSGALLGLLILLLAPTLVVG 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447105862 345 IIYLLIGlaGIGSVGITQILNAYVTQYFPSHiRATSLGWGLGLGRVGAIAGPILVGII 402
Cdd:cd17333 292 LVATALL--GLFMAALFPTILSLGISNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
278-431 |
1.66e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 278 LPQMMRQAGYPLGSSLSFLLML-NITAAIGALFAGAIADRIGAKIVISISYLMAAI--CIGLLTikPSVSIIYLLIGLAG 354
Cdd:cd17473 22 LPAIAQHFVPNSELLVPLLLTLpALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIggVAGLFL--DSLYALLASRALLG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447105862 355 IGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAwnFYLFSFAGLLAAISVFFIP 431
Cdd:cd17473 100 IGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAP--FLVYLLALPVLILVLLFLP 174
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
278-432 |
1.91e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 278 LPQMMRQAGyPLGSSLSFLLMLNITAAIGALFA----GAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLA 353
Cdd:cd17330 19 LPFYVREFN-KLGASGYYVGLLQSSYSLGQFLAsplwGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447105862 354 GIGSVGITqILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMqYDLAWNFYLFSFAGLLAAISVFFIPT 432
Cdd:cd17330 98 GLTGGNVS-VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP-YGYALPFLVAAALALLNLVLVLFFLP 174
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
14-382 |
2.21e-04 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 43.55 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 14 TIFSNSITKLVVFICWLAILADGYDLGIYGAV---LPKLLEDNSwalSPAhAGTIASYALFGM-FI----GAILVGTITD 85
Cdd:PRK10642 7 TIIDDGKLRKAITAASLGNAMEWFDFGVYGFVayaLGKVFFPGA---DPS-VQMIAALATFSVpFLirplGGLFFGMLGD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 86 LIGRKWTLICCLALFSITMGLAALAPSPELFGLW--------RFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTG 157
Cdd:PRK10642 83 KYGRQKILAITIVIMSISTFCIGLIPSYATIGIWapillllcKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 158 YPLGIVLGA----ILSMFMLE----DFGWRIMFGIGMiPLLLIPFIIRY-LPESIQFllsrnrQEEVDKIlnrfqiefyA 228
Cdd:PRK10642 163 SIAGFVLGAgvvvLISTIVGEanflDWGWRIPFFIAL-PLGIIGLYLRHaLEETPAF------QQHVDKL---------E 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 229 KDETHQAPSniRKKNGFLTLFSKEyiKATLLFWITYIMGMFLI-YGLNTWLPQMMrqaGYPLGSSLSFLLMLNITAAIGA 307
Cdd:PRK10642 227 QGDREGLQD--GPKVSFKEIATKH--WRSLLTCIGLVIATNVTyYMLLTYMPSYL---SHNLHYSEDHGVLIIIAIMIGM 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 308 LFA----GAIADRIGAKIVIsisyLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYV-------TQYFPSHI 376
Cdd:PRK10642 300 LFVqpvmGLLSDRFGRRPFV----ILGSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTgvmastlPAMFPTHI 375
|
....*.
gi 447105862 377 RATSLG 382
Cdd:PRK10642 376 RYSALA 381
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
57-402 |
3.05e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 57 LSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASA 136
Cdd:cd17328 31 IDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 137 LTVEYSPKKRQSFIYALMFTGYPLGIVLGAIL-SMFMLEDFGWRIMF---GIGMIPLLLIPFIIRYLPESIQfllsrnrq 212
Cdd:cd17328 111 IIADLFPKEKRTRALGVFYFAIPLGSGLGYVVgGLVAQATGGWRWAFrvtGVLGVLLAILLLLFVREPPRGA-------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 213 eevdkilnrfqiefyAKDETHQAPSNIRKKNGFLTLFSKeyiKATLLFWITYIMGMFLIYGLNTWLPQ-MMRQAGYPLGS 291
Cdd:cd17328 183 ---------------AEGGVMAKSTATSFLADLKALAKN---PSFILSTLGFTAVSFVTGALAFWAPTfFLRAFGVGDLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 292 ----SLSFLLMLNITAAIGALFAGAIADRIGAK------IVISISYLMAAICIGLLTIKPSVSIIYLLI-GLAGIGSVGI 360
Cdd:cd17328 245 sadvGLIFGAITCIAGVLGVLLGGILADRLRRKtpradpLVCAVGLLAAAPFLFLALVLALSNLLLAWVlLFLGEFLLSL 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447105862 361 TQILNAYVTQY--FPSHiRATSLGW-GLGLGRVGAIAGPILVGII 402
Cdd:cd17328 325 NWAPVFAILLYvvIPTR-RSTASAIqILLSHLLGDAGSPYLIGLI 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
301-431 |
3.37e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.56 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 301 ITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATS 380
Cdd:cd17474 45 LPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKA 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 447105862 381 LGWGLGLGRVGAIAGPILVGIIMTMQYdlAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17474 125 MGLYEAALGLGIAVGPLLGGLLAAISW--RYPFFLLAALIPVAFLAILFLL 173
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
63-353 |
4.14e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.16 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 63 GTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW--RFIGGIGLGGVIPTASALTVE 140
Cdd:cd17380 37 GLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLIlsRILLGLGEGVHFPSMTSLFSR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 141 YSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMF-GIGMIPLLLIPFIIRYLPEsiqfllsrnrqeevdkil 219
Cdd:cd17380 117 WVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFyFFGLLGLLWALVWLIYLPP------------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 220 nrfqiefyakdethqapsnirkkngfltlfskeyikatllFWITYI---MGMFLIYGLNTWLPQMMRQAGYPLGSSLSFL 296
Cdd:cd17380 179 ----------------------------------------VWAIIVahfCMNWGFYILLSWLPTYFHEVLVPLAKGWVFN 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447105862 297 LMLNITAAIGALFAGAIADRIGA---------KIVISISYLMAAICIGLL--TIKPSVSIIYLLIGLA 353
Cdd:cd17380 219 VVPWLVMFPSSNVAGWLADHLISrgwtvtsvrKLMQSIGFLGPALFLLLLshTDSFSLALLCMSVALG 286
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
51-207 |
5.38e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.85 E-value: 5.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 51 EDNSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALA-PSPELFGLWRFIGGIGLGG 129
Cdd:cd17356 36 NTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGF 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 130 VIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSM---FMLEDFGWRIMFGIGMIPLLLIPFIIRYLPESIQFL 206
Cdd:cd17356 116 ASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYgthKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL 195
|
.
gi 447105862 207 L 207
Cdd:cd17356 196 Y 196
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
63-254 |
5.45e-04 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 41.99 E-value: 5.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 63 GTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITmGLAALAP--------SPELFGLWRFIGGIGLGGV-IPT 133
Cdd:PRK10077 58 GFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFIS-ALGSAWPefgftsigPDNTGYVPEFVIYRIIGGIgVGL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 134 ASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFM------------LEDFGWRIMFGIGMIPLLLIPFIIRYLPE 201
Cdd:PRK10077 137 ASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVnyfiarsgdaswLNTDGWRYMFASEAIPALLFLMLLYFVPE 216
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 447105862 202 SIQFLLSRNRQEEVDKILNRFQIEFYAK---DETHQAPSNIRKKNGFLTLFSKEYI 254
Cdd:PRK10077 217 TPRYLMSRGKQEQAEGILRKIMGNTLATqalQEIKHSLDHGRKTGGKLLMFGVGVI 272
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
70-429 |
6.77e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.60 E-value: 6.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 70 LFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSF 149
Cdd:TIGR00710 50 LLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSR 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 150 IYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFG-IGMIPLLLIPFIIRYLPESiqflLSRNRQEEVDKILNRFQIEFya 228
Cdd:TIGR00710 130 IYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAfLSLAGILLSALIFFILPET----LPYEARIQISTYFETFLLLL-- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 229 kdethqapsniRKKNGFLTLFSKEYIKATLLFWITyiMGMFLIYGLNTWLPQMmrqagyplgssLSFLLMLNITAAI-GA 307
Cdd:TIGR00710 204 -----------KSKMFWGYALIYGASFGGFFAFFS--GAPFVYIDIMGVSPSV-----------FGLLFALNIIAMIfGG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 308 LFAGAIADRIGAKIVISISYLMAAICIGLLTIK-----PSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHI-RATSL 381
Cdd:TIGR00710 260 FLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITailglGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAgTASAL 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 447105862 382 GWGLGLGrVGAIAGPILVGIIMtmqyDLAWNFYLFSFagLLAAISVFF 429
Cdd:TIGR00710 340 FGTLRLV-LGAIVGYLVSLIHG----NTAWPMSLSCL--VLAVVSVLA 380
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
255-402 |
7.61e-04 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 41.44 E-value: 7.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 255 KATLLFWITYimgMFLIYGLNTwlpqMMRQA--------GYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISIS 326
Cdd:cd17482 188 KQLLLFLIAY---FFYIDGVQT----IIRMAtiygaeegKLGSSALILALLLTQFVAFPGALLFGWLAERFGAKRAILVS 260
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447105862 327 yLMAAICIGLLTIK-PSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPILVGII 402
Cdd:cd17482 261 -LVIYILICIYAYFmLTAWDFWILAALIGLVQGGIQALSRSLFGRLIPKGKSAEFFGFYNISGKFAAIIGPLLFGLI 336
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
37-197 |
7.97e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 41.57 E-value: 7.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 37 YDLGIYGaVLPKLLEDNSWALSPAHAGTIASYALFGMF-----IGAILVGTITDLIGRKWTLICCLALFSITMGLAALAP 111
Cdd:cd17366 13 FDFGVYG-YLAVTIGKVFFPGGDPTAQLLATFATFAVAflvrpLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 112 SPELFGLW--------RFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALM----FTGYPLGIVLGAILSMFM----LED 175
Cdd:cd17366 92 TYATIGVWapillllaRMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLefgtLAGFILGAGLVTLLTLLLteaqMLD 171
|
170 180
....*....|....*....|..
gi 447105862 176 FGWRIMFGIGMiPLLLIPFIIR 197
Cdd:cd17366 172 WGWRIPFLIAA-PLGLVGLYLR 192
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
298-431 |
1.40e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.64 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 298 MLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIR 377
Cdd:cd17315 42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIR 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 447105862 378 ATsLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWN--FYLFSFAGLLAAISVFFIP 431
Cdd:cd17315 122 GA-LGTLNQLMITFGILLAYLLGLALSLSPPGWWRlmFALAAVPALLQLLLMFFLP 176
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
75-213 |
1.82e-03 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 40.31 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 75 IGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLW--------RFIGGIGLGGVIPTASALTVEYSPKKR 146
Cdd:PRK15075 71 LGAIVLGAYIDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAapllvllgRLLQGFSAGVELGGVSVYLAEIATPGR 150
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447105862 147 QSFI---------YALMFTGYpLGIVLGAILSMFMLEDFGWRIMFGIGmipLLLIPFIirylpesiqFLLSRNRQE 213
Cdd:PRK15075 151 KGFYtswqsasqqVAVVFAAL-LGYLLNQWLSPAQMAEWGWRIPFLIG---CLIVPFI---------FLIRRSLEE 213
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
44-430 |
2.00e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.28 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 44 AVLPKLLEdnSWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFGLWRFig 123
Cdd:cd17331 21 PVLPYLTK--KLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL-- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 124 GIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFGIGMIPLLLIPFIIRYLPESI 203
Cdd:cd17331 97 PSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSN 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 204 QFLLSRNRQEEVDKILNRFQIEFYakdethqapSNIRKKNGFLTLFSkeyIKATLLFWITYIMGMFLIYGLNTwLPQMMR 283
Cdd:cd17331 177 TKSKREKEAKESASPPSVFNLKEI---------LRLLRLPGVAFLLL---VKLLSGLPIGMFQSMFSLVAMDF-FGLTPE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 284 QAGYPLgsSLSFLLmlniTAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQI 363
Cdd:cd17331 244 ENGYLM--SYAGVL----GMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447105862 364 LNAYVTQYFPSHIRATSLGWGLGLGRVGAIAGPiLVGIIMTMQYDLaWNFYLFSFAGLLAAISVFFI 430
Cdd:cd17331 318 ITSLLTKAVPPEDTGTALGLSHALFSLVRTVSP-TIGGALLQAYGF-PSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
317-431 |
2.10e-03 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 40.18 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 317 IGAKIVISISYLMAAICIGLLTI-KPSVSIIYLLIGLAGIGSVGITqILNAYVTQYFPSHIRATSLGWGLGLGRVGAIAG 395
Cdd:cd17442 263 LGRRLSLVITMGLTAIFFLLLNIcTSSAGLTIFLFMLRALVSANFN-TVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVA 341
|
90 100 110
....*....|....*....|....*....|....*.
gi 447105862 396 PILVGIIMTMQYDLAwnFYLFSFAGLLAAISVFFIP 431
Cdd:cd17442 342 PFISQVLMSASVLGA--LCLFSSVCIVCAISAFTLP 375
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
89-200 |
2.24e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 39.87 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 89 RKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAIL 168
Cdd:PRK03545 73 RRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPL 152
|
90 100 110
....*....|....*....|....*....|...
gi 447105862 169 SMFMLEDFGWRIMFG-IGMIPLLLIPFIIRYLP 200
Cdd:PRK03545 153 GRVIGQYLGWRTTFLaIGGGALITLLLLIKLLP 185
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
8-196 |
3.74e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 8 HLESTKTIFSNSITKLVVFICWLAILadgydlgiygAVLPKLLEdNSWALSPAHAGTIASYALFGMFIGAILVGTITDL- 86
Cdd:cd17474 193 KALRGRGLLTFLVSAFLYFFLYFAFL----------TYLPFLLE-LLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKr 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 87 IGRKWTLICCLALFSITMGLAALAPSPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGA 166
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP 341
|
170 180 190
....*....|....*....|....*....|
gi 447105862 167 ILSMFMLEDFGWRIMFGIGMIPLLLIPFII 196
Cdd:cd17474 342 LLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
294-431 |
3.80e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.07 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 294 SFLL-MLNITAAIGALFAGAIADR--IGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQ 370
Cdd:cd17352 221 AFLLsIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILAD 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447105862 371 YFPSHIRATSLGWGLGLGRVGAIAGPILVGIIMTMQYDLAWNFYLFSFAGLLAAISVFFIP 431
Cdd:cd17352 301 LVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
38-355 |
4.24e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 39.31 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 38 DLGIYGaVLPKLLEDnsWALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSITMGLAALAPSPELFG 117
Cdd:PRK10091 19 EFGIMG-VLTELAHD--VGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 118 LWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMFG-IGMIPLLLIPFII 196
Cdd:PRK10091 96 IGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLlIAVFNIAVLASIY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 197 RYLPESiqfllsrnrqEEVDKILNRFQIEFYAKdethQAPsnirkkngFLTLFSKEYIKATLLFWITYIMgmfliyglnt 276
Cdd:PRK10091 176 FWVPDI----------RDEAKGGLREQFHFLRS----PAP--------WLIFAATMFGNAGVFAWFSYIK---------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 277 wlPQMMRQAGYPlGSSLSFLLML-NITAAIGALFAGAIADRIGAKIVISISYLMaaICIGLLTI-----KPSVSIIYLLI 350
Cdd:PRK10091 224 --PYMMFISGFS-ETSMTFIMMLvGLGMVLGNLLSGRLSGRYSPLRIAAVTDFI--IVLALLMLfffggMKTASLIFAFI 298
|
....*
gi 447105862 351 GLAGI 355
Cdd:PRK10091 299 CCAGL 303
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
26-187 |
5.73e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 38.78 E-value: 5.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 26 FICWLAILADGYDLGIYGAVLPKLLEdnSWALSPAHAG-TIASYAL-FGMFIgaILVGTITDLIGRKWTLICCLALFSIT 103
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGD--SFGTSPNQLSwLAASYSLtVGTFI--LIFGRLGDIYGHKKMFVIGSFWFAIW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 104 MGLAALAPSPELFGLWRFIGGIGLGGVIPTASA-LTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRIMF 182
Cdd:cd17476 77 SLIAGFSPNFIFFIICRALQGLGPAFLLPNAMAlLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156
|
....*
gi 447105862 183 GIGMI 187
Cdd:cd17476 157 WFLAI 161
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
261-428 |
5.74e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.90 E-value: 5.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 261 WITYIMGMFLIYGLNTWLPQMMRQAGYPLGSSLSFLLMLNITAAIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIK 340
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 341 PSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLG-WGLGLgRVGAIAGPILVGIIMTMQYDLAWNFYLFSFA 419
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSfWNCSH-NVGGGLLPPLVLFGIAELYSWHWVFIVPGII 159
|
....*....
gi 447105862 420 GLLAAISVF 428
Cdd:TIGR00881 160 AIIVSLICF 168
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-196 |
8.97e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 37.97 E-value: 8.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 23 LVVFICWLAILADGYDLGIYgavLPKLLEDNSwALSPAHAGTIASYALFGMFIGAILVGTITDLIGRKWTLICCLALFSI 102
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTF---LPTYLQTVL-GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 103 TMGLAALAP--SPELFGLWRFIGGIGLGGVIPTASALTVEYSPKKRQSFIYALMFTGYPLGIVLGAILSMFMLEDFGWRI 180
Cdd:cd17316 256 LALPLFYLLsgSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*.
gi 447105862 181 MFGIGMIPLLLIPFII 196
Cdd:cd17316 336 VPALILALLAIVALIV 351
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
304-430 |
9.85e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 37.92 E-value: 9.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447105862 304 AIGALFAGAIADRIGAKIVISISYLMAAICIGLLTIKPSVSIIYLLIGLAGIGSVGITQILNAYVTQYFPSHIRATSLGW 383
Cdd:cd17477 45 LLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGL 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447105862 384 GLGLGRVGAIAGPILVGIIMTMqydlAWNFYLFSFAGLLAAISVFFI 430
Cdd:cd17477 125 YSTVLGLGFALGPLLLALVGTA----GALPFLIAAVLLLLALVPLLL 167
|
|
| |
