|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-378 |
8.85e-100 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 301.05 E-value: 8.85e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 15 CFSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 95 AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS 174
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 175 LLAFLLGLLVDIPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSEiASYFFILYALV 254
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN-AGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 255 VVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATA 334
Cdd:cd17489 240 LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 447113062 335 TYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLY 378
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-379 |
1.66e-51 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 176.61 E-value: 1.66e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 15 CFSSLFLFLTFYMLMTTLPVYViDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 95 AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 175 LLAFLLGLLVD-----IPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGL--SEIASYF 247
Cdd:cd17325 161 LLALVLALLLLpeprpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlsPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 248 FILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNH 327
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447113062 328 RRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-344 |
1.16e-44 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 157.83 E-value: 1.16e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 171 SVFSLLAFLLGLLVdIPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLSE-IASYFF 248
Cdd:COG2814 171 AVLALLALLLLLRL-LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSAsAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 249 ILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHR 328
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....*.
gi 447113062 329 RGSATATYFSFFDSGI 344
Cdd:COG2814 330 RGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-348 |
3.25e-39 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 143.33 E-value: 3.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 14 TCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYF 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 94 GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVF 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 174 SLLAFLLGLLVDIPHEAPVSKQKREK-----MKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSEIASYFF 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEArlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 249 I-LYALVVVISRPFTGKIFDRFGEN---VLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAA 324
Cdd:pfam07690 241 LgLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 447113062 325 PNHRRGSATATYFSFFDSGIGFGS 348
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-387 |
4.06e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 110.73 E-value: 4.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 15 CFSSLFLFLTFYMLMTTLPV---YVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVM 91
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVaapPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 92 YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCS 171
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 172 VFSLLAFLlgllvdipheapvskqkrekmkwkdliePSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLS-EIASYFFI 249
Cdd:COG2271 172 LPGLLLAL----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSlAQAGLLLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 250 LYALVVVISRPFTGKIFDRFGENVLVYPAI--IIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNH 327
Cdd:COG2271 224 LPFLAGIVGSLLGGWLSDRLGRRRKLVLAIglLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 328 RRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYGLHGRKQK 387
Cdd:COG2271 304 ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-379 |
9.78e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 109.97 E-value: 9.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPvYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILP-AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLG--LTIISHFSFTVLFI 168
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGglLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 169 VCSVFSLLAFLLGLLVDIPHEAPVSKQKREKMKwKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKEL--GLSEIASY 246
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDLK-KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLygISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 247 FFILYALVVVISRPFTGKIFD-RFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAP 325
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447113062 326 NHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-356 |
5.41e-26 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 107.64 E-value: 5.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 14 TCFSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYF 93
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARD-LGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 94 GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVF 173
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 174 SLLAFllgllvdipheapvskqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLSEI-ASYFFILY 251
Cdd:cd17321 160 GLVAL--------------------------LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLqAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 252 ALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFW---FLGAGMLIGLGYGTLIPSFQTIAISAAPNHR 328
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSvwlLLPGLVLLGLGLGLFATPLTNAALSSVPKEK 293
|
330 340
....*....|....*....|....*...
gi 447113062 329 RGSATATYFSFFDSGIGFGSFILGIVAA 356
Cdd:cd17321 294 AGAASGILNTARQLGGALGVALLGALLT 321
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
16-381 |
1.25e-25 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 106.54 E-value: 1.25e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 96 QSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIIShFSFTVLFI---VCSV 172
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLaaaVLFL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 173 FSLLAFLLGLLVDIPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGL--SEIASYFFIL 250
Cdd:cd17329 165 LAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGlgESLLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 251 YALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRG 330
Cdd:cd17329 245 NALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRG 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 447113062 331 SATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYGL 381
Cdd:cd17329 325 SYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-379 |
1.97e-25 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 106.16 E-value: 1.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 16 FSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFIS-----LSLFLAATV 90
Cdd:cd06173 6 LAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:cd06173 85 ALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 171 SVFSLLAFLLGLLvdIPHEAPVSKQKREKMKWKDLIE--------PSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLS 241
Cdd:cd06173 165 ALSFLLSALLLLF--IRRPPPAAPGESSSLLLRDLREglrylrrsPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 242 EIA-SYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIA 320
Cdd:cd06173 243 AAGyGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLL 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447113062 321 ISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd06173 323 QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
16-377 |
3.50e-25 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 105.32 E-value: 3.50e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 16 FSSLFLFLTFYMLMTTLPVyVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:cd17324 6 LAAFAIGTTEYVIQGLLPD-IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 96 QSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSL 175
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 176 LAFLLGLLV--DIPHEAPVSKQKReKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKEL--GLSEIASYFFILY 251
Cdd:cd17324 165 LAALLLWRLlpSLPPKKPGSLGLL-SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpgFSSSAIIGLLLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 252 ALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHrRGS 331
Cdd:cd17324 244 GVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447113062 332 ATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17324 323 ASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-387 |
5.44e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.57 E-value: 5.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 12 LGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVM 91
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 92 YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCS 171
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 172 VFS--LLAFLLGLLVDIPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLSEI-ASYF 247
Cdd:COG2223 167 ILLlvVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAAtAGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 248 FILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFW-FLGAGMLIGLGYGTLIPSFQTIAISAAPN 326
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWlFLVLFLLLGLALGGGNGAVFALVPDIFPT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447113062 327 HRRGSATATYFSFFDSGIGFGSFILG-IVAAKSSYHNMYFIAAIIVAFTLLLYYGLHGRKQK 387
Cdd:COG2223 327 KNAGAVYGLVGAAGGLGGFLGPLLFGaLLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-174 |
3.93e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.79 E-value: 3.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA 88
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 89 TVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFI 168
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
....*.
gi 447113062 169 VCSVFS 174
Cdd:cd17325 359 AAAALL 364
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-377 |
6.76e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 93.03 E-value: 6.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 27 MLMTTLPVyVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRF 106
Cdd:cd17504 14 MLSPALPT-IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 107 LHGIGFGMATTATGtIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVDI 186
Cdd:cd17504 93 LQGIGGAVFPLAFA-LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 187 pheapvsKQKREKMKWKdliepSSIPIALTGFVLAFSYSGILSFIPI-YAKELGLSEIASYFFIL-YALVVVISRPFTGK 264
Cdd:cd17504 172 -------RLLRRRNVLL-----ANITALLAGFGMFMVFQLLPQLLQLpTPTGFGLGITEAGLLLLpGALVMLIAGPLAGR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 265 IFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLI-GLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSG 343
Cdd:cd17504 240 LIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLiGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 447113062 344 IGFGSFILGIVAAKSS-------------YHNMYFIAAIIVAFTLLL 377
Cdd:cd17504 320 SAIGPAIAGAILTTYTvsitsggvptegaYVLAFLIGAALALAALLL 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-390 |
6.81e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 93.38 E-value: 6.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:COG0738 44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 126 VAPAHRRGeALAYFGVFMSLPMVIGPFLGLTIISH---FSFTVLFIVCSVFSLLAFLLGLLVDIPHEAPVSKQKREkmKW 202
Cdd:COG0738 124 LGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG--SA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 203 KDLIEPSSIPIALTGFVLAFSYSG----ILSFIPIYAKE-LGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLVY 276
Cdd:COG0738 201 ASLKSLLKNPRLLLGGLAIFLYVGaegaIGDWLPLYLKDvLGLSEaTAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 277 PAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHrRGSATATYFSFFDSGIGFGSFILGIVAA 356
Cdd:COG0738 281 LSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLAD 359
|
330 340 350
....*....|....*....|....*....|....
gi 447113062 357 KSSYHNMYFIaaIIVAFTLLLYYGLHGRKQKFKK 390
Cdd:COG0738 360 AFGLRAAFLV--PLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
16-377 |
9.83e-21 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 92.62 E-value: 9.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 96 QSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLgLTIISHFSFTvLFIVCSVFSL 175
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGAL-PFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 176 LAFLLGLLVdiPHEAPVSKQkREKMKWKDLIepSSIPIALTG-FVLAFSYSGILSFIPIYAKELGLSE-IASYFFILYAL 253
Cdd:cd17477 160 LALVPLLLT--RRAAPEIEE-AESISLRRLL--RIAPLALLGaFVAGFLEGAFYSLLPLYGLRLGLSVaQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 254 VVVISRPFTGKIFDRFG-ENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSA 332
Cdd:cd17477 235 GGLLLQWPLGWLADRFDrRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447113062 333 TATYFSFFDSGIGFGSFILGIVAAKSSYHNM-YFIAAIIVAFTLLL 377
Cdd:cd17477 315 NAALLLLYGLGSVIGPLLAGALMDAFGPHGLfLFLAAVALLFLLFL 360
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
44-354 |
1.33e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 92.25 E-value: 1.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17503 30 LDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTIL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVDIpheapvskqkrekmkwK 203
Cdd:cd17503 110 LRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLDL----------------R 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 204 DLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLS-EIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIII 281
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSaFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447113062 282 FTIGMFILSQ--AQTSFWFL-GAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIV 354
Cdd:cd17503 254 LALGTLLLAFltPDTSLWLIiLPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-379 |
6.74e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.18 E-value: 6.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 15 CFSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 95 AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT---------V 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwravfliaaA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 166 LFIVCSVFSLLAFLLGLLVDIPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLS--EI 243
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsvAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 244 ASYFFILYALVVVISRPFTGKIFDR-FGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAIS 322
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113062 323 AAPNHRRGSATATYFSFFDSGIGFGSFILGIV-AAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-379 |
7.88e-20 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 89.94 E-value: 7.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17473 34 ELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLG---LTIISHFSFTV--LFIVCSVFSLLAfllgllvdIPHEAPVSKQKRE 198
Cdd:cd17473 114 GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGgalAEIGWRAPFLVylLALPVLILVLLF--------LPEPARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 199 --KMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGL--SEIASYFFILYALVVVISRPFTGKIFDRFGENVL 274
Cdd:cd17473 186 pgAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgsAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 275 VYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILG-I 353
Cdd:cd17473 266 LAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGpL 345
|
330 340
....*....|....*....|....*.
gi 447113062 354 VAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17473 346 VNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
18-378 |
1.89e-19 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 89.17 E-value: 1.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 18 SLFLFLTFY---MLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:PRK05122 21 VMFTFISYLtigLPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 95 AQ--------SLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVL 166
Cdd:PRK05122 101 AGllaawpvlSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 167 FIVCSVFSLLAFLLGLLVDiphEAPVSKQKREKMkWKDLIEpssipIALTGFVLAFS---YSGILSFIPIYAKELGLSEi 243
Cdd:PRK05122 181 GLLIMLLALLGLLLARPRP---AVPPVKGERLPF-RRVLGR-----VWPYGMGLALAsigFGTIATFITLYYAARGWDG- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 244 ASYFFILYALVVVISRPFTGKIFDRF-GENVlvypAIIIF---TIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTI 319
Cdd:PRK05122 251 AALALTLFGVAFVGARLLFGNLINRLgGLRV----AIVSLlveILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447113062 320 AISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII----VAFTLLLY 378
Cdd:PRK05122 327 AVKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAallgLALTWLLY 389
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
16-377 |
5.86e-19 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 87.81 E-value: 5.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:PRK12382 22 FAVFLTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGLAYLLA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 96 ---QSLFLLLALRFLHG---IGFGMATTATGTI---VTDVAPAHRrGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVL 166
Cdd:PRK12382 102 ailPVSAPFKFALLVVGrliLGFGESQLLTGALtwgLGLVGPKHS-GKVMSWNGMAMYGALAAGAPLGLLLHSHFGFAAL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 167 FIVCSVFSLLAFLLGLLVdipheAPVSKQKREKMKWKDLIEPssipIALTGFVLAFS---YSGILSFIPIYAKELGLSeI 243
Cdd:PRK12382 181 ALTTMVLPLLAWAFNGTV-----RKVPAHAGERPSLWSVVGL----IWKPGLGLALQgvgFAVIGTFVSLYFASKGWA-M 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 244 ASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISA 323
Cdd:PRK12382 251 AGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKR 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447113062 324 APNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:PRK12382 331 VPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIV 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-174 |
7.56e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 84.18 E-value: 7.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLkgkPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA 88
Cdd:cd17489 194 KKVLPPALILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 89 TVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFI 168
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFL 350
|
....*.
gi 447113062 169 VCSVFS 174
Cdd:cd17489 351 LAAVVV 356
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
25-377 |
1.19e-17 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 83.40 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 25 FYMLMTTLPVYVID--GLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLL 102
Cdd:cd17330 12 FGIVFPVLPFYVREfnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 103 ALRFLHGIgFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGL 182
Cdd:cd17330 92 LARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 183 lvdipheapvskqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIPIYAK---ELGLSEIASYFFILYALVVVISR 259
Cdd:cd17330 171 ----------------------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKdrfGFSPSQIGLLLALVGIAGILAQL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 260 PFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSF 339
Cdd:cd17330 229 LLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSL 308
|
330 340 350
....*....|....*....|....*....|....*...
gi 447113062 340 FDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17330 309 QSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
47-377 |
4.55e-17 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 81.46 E-value: 4.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 47 IGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDV 126
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 127 APAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIV---CSVFSLLAFllgllvdipheapvskqkrekmkwk 203
Cdd:cd17502 112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInlpIGGLALALL------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 204 dliePSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLSEI-ASYFFILYALVVVISRPFTGKIFDRFG-ENVLVYPAII 280
Cdd:cd17502 167 ----RTILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATkSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 281 IFTIGMFILSQ--AQTSFWFL-GAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATyFSFFDSgIGFGSFIlgivaak 357
Cdd:cd17502 243 LMSVGAGLLTTltLDTSKWLLiGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATAT-NTFFRS-LGGTLGV------- 313
|
330 340
....*....|....*....|
gi 447113062 358 sSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17502 314 -AITDVFLVALALAALAFLL 332
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
22-376 |
1.03e-16 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 80.72 E-value: 1.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 22 FLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVF-LISSVLCRPFtGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFL 100
Cdd:cd17472 9 MLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYgLTQAIFQIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 101 LLALRFLHGIGfgmATTATGT-IVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLL-AF 178
Cdd:cd17472 88 LILGRALQGSG---AISSVVMaLLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVsLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 179 LLGLLVDIPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSEIASYFFILYALVVVIs 258
Cdd:cd17472 165 ILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGF- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 259 rpFTGKIFDRFGENV-----LVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIG-LGYGTLIPSFQTIAISAAPNHRRGSA 332
Cdd:cd17472 244 --ILMVPFVIYAEKKgkmkqVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFfIGFNLLEALLPSLVSKIAPKEYRGTA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 447113062 333 TATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLL 376
Cdd:cd17472 322 MGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
213-377 |
1.58e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.02 E-value: 1.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPaQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
....*.
gi 447113062 372 AFTLLL 377
Cdd:COG2814 175 LLALLL 180
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-379 |
1.95e-16 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 79.96 E-value: 1.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 15 CFSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKIlFISLSLFLA--ATVMY 92
Cdd:cd17490 2 LIIVFLFWFSQYVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKL-FIIIGLLFTvlASLIM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 93 FGAQSLFLLLALRFLHGIGFGMATTATgTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSV 172
Cdd:cd17490 80 ILFPSPWGLLIARFLSGIAAATWVSFT-VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 173 FSLLAFLLGLLVDIPHEAPVSKQKREK-----MKWKDLIEPSsipiALTGFVLAFSYSGILSFIPIYAKELG-----LSE 242
Cdd:cd17490 159 AGVLGFILSLFIKEERREKKPVLTELKellsvLKDKKLLFFS----LLAILQQMITFSTTFGFTPLIAKQLGassfqLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 243 IASYFFILYALVVVISRPFtgkIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAIS 322
Cdd:cd17490 235 LSIIYLLPNALASLLSGTL---FYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIE 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447113062 323 AAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII--VAFTLLLYY 379
Cdd:cd17490 312 GVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIalLAAILSLAY 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
213-398 |
1.44e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.25 E-value: 1.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSEIASYFFI-LYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVgLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180
....*....|....*....|....*..
gi 447113062 372 AFTLLLYYGLHGRKQKFKKQPTDGKIS 398
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEAEAGTRA 187
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
213-381 |
2.07e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 2.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVaQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170
....*....|
gi 447113062 372 AFTLLLYYGL 381
Cdd:cd17325 161 LLALVLALLL 170
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
16-379 |
3.60e-15 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 76.15 E-value: 3.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEI----GLVATVFLISSVLCRPFTGKWLDDLGRKKILF-ISLSLFLAATV 90
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLrASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFgAQSLFLLLALRFLHGIGFGMATTATgTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:cd17391 83 MAF-VTNVWQLLILRLLQGVFSGYVPNAT-ALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 171 SVFSLLAFLLGLLVDIPHEAPVSKQKREKMK--WKDLIEPSSI-PIALTGFVLAFSYSGILSFIPIYAKELG-----LSE 242
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKevWNSVPNPSLLiSLFVTTFIIQLANQSIEPILTLYIRQLMgdasnLAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 243 IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAIS 322
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447113062 323 AAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17391 321 ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSF 377
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-381 |
1.22e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 74.53 E-value: 1.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17320 33 ASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVdIPHEAPVSKQK-REKMKW 202
Cdd:cd17320 113 RDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF-LPETLPEEKRKpLLSSLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 203 KDLIEPSSIPIALT-GFVLAFSYSGILSFIP----IYAKELGLS-EIASYFFILYALVVVISRPFTGKIFDRFGENVLVY 276
Cdd:cd17320 192 RAYKRVLKNRRFLGyALALGLSFAGLFAYLAaapfIYIEQLGLSpAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 277 PAIIIFTIG-----MFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPnHRRGSATATYFSFFDSGIGFGSFIL 351
Cdd:cd17320 272 LGLLLLLAAalvllLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALV 350
|
330 340 350
....*....|....*....|....*....|
gi 447113062 352 GIVAAkSSYHNMYFIAAIIVAFTLLLYYGL 381
Cdd:cd17320 351 GLLPN-GTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-377 |
2.93e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 73.36 E-value: 2.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 47 IGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDV 126
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 127 APaHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF---SFTVLFIVCSVFSLLAFLLGLLvDIPHEAPVSKQKREKMKWK 203
Cdd:cd17478 113 AG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFgglGLLILLIIPGLAVALLLLRLRP-LKKPEAKKAAAKSSARSTL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 204 DLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSEI-ASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIF 282
Cdd:cd17478 191 KGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVfAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 283 TIGMFILSQAQtSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHrRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHN 362
Cdd:cd17478 271 APFLLLFLLTP-GIWSYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLES 348
|
330
....*....|....*
gi 447113062 363 MYFIAAIIVAFTLLL 377
Cdd:cd17478 349 VLLILALLPLLGALL 363
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
17-377 |
5.11e-14 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 72.58 E-value: 5.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 17 SSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLG-RKKILFIS-LSLFLAATVMYFG 94
Cdd:cd17471 4 ATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLAlLAGALGYLLFAFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 95 AQSLFLLLALRFLHGIGfGMATTATGTIVTDVAPAHRRGEALAYFGV---FMSLPMVIGPFLGLTIISHFSFTVLFIVCS 171
Cdd:cd17471 84 RNYWVLLLVGVVLLSLG-AAAFPQLFALAREYADRSSGRDATLFNSVlraAFSLAWVIGPPLAFLLLDVLGFTGLFLLAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 172 VFSLLAFLLGLLV--DIPHEAPVSKQKREKMKWKDliePSSIPIALTGFVLAFSYSGI-LSFIPIY-AKELGLSEiaSYF 247
Cdd:cd17471 163 LLYLVVALLVLFLlpSVKPPAQKATPASSLVKAPV---NRRLLLLFAAFTLLFAANSMyIIAMPLYvTNELGGSE--SWV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 248 FILYALVVVISRPF---TGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTlipsFQTIAISAA 324
Cdd:cd17471 238 GLLFGLAAALEIPImllAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGI----TAGLGISYF 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447113062 325 PN---HRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17471 314 QDlmpGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
12-377 |
5.67e-14 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 72.58 E-value: 5.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 12 LGTCFSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVM 91
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 92 YFG-AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEAlayFGVFMSLPM---VIGPFL--GLTIISHFSFTV 165
Cdd:cd17370 81 LLAlAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKA---FGLHRALDTlgaVLGPLLaaLLLYLLGGNYRT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 166 LFIVCSVFSLLAFLL-GLLVDIPHEAPVSKQKREKMKWKDLiePSSIPIALTG-FVLAFSYSGIlSFIPIYAKELGLS-E 242
Cdd:cd17370 158 IFLLAAIPALLALLIlLFVVKEYPRPPKLRKKSKKTSLKKL--PKAFWLYLLAvALFALGNFSF-AFLILRAQELGLSaA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 243 IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAIS 322
Cdd:cd17370 235 LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVAD 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 447113062 323 AAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17370 315 LVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-290 |
1.10e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.00 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPVYViDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 171 SVFSLLAFLLGLLVDIPHEAPVSKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSEIASYFFIL 250
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 447113062 251 YALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILS 290
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
213-379 |
5.41e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 69.37 E-value: 5.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIY-AKELGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILS 290
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPtEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 291 QAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII 370
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
....*....
gi 447113062 371 VAFTLLLYY 379
Cdd:pfam07690 161 SLLAAVLLL 169
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
46-378 |
1.68e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.07 E-value: 1.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRF-LHGIGFGMATTATGTIVT 124
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGlLGGGGAGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 125 DVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS-------FTVLFIVCSVFSLLAFLLGLLVDIPHEAPVSKQKR 197
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwrtallvLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 198 EKMKWKDLIEPSSIPI-ALTGFVLAFSYSGILSFIPIYAKELGLSEI-ASYFFILYALVVVISRPFTGKIFDRFGENVLV 275
Cdd:cd17355 199 PGSTLKEALRSASFWLlALAFFLCGFAVVGLIVHLVPYLADRGISPAaAAVALALIGLFNIVGRLLSGWLGDRYSPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 276 YPAIIIFTIGMFILSQAQ-TSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIV 354
Cdd:cd17355 279 AASYALRALGLALLLLLPfPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
330 340
....*....|....*....|....*..
gi 447113062 355 AAKSSYHNMYFIAAI---IVAFTLLLY 378
Cdd:cd17355 359 YDRTGSYTAAWALAValgLIAALLVLP 385
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
46-377 |
2.43e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.98 E-value: 2.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 126 VAPaHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVDIPHEAPVSKQKREKMKWKDL 205
Cdd:COG2807 134 WFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLW 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 206 IEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSE-IASYFFILYALVVVISRPFTGKIFDRFG-ENVLVYPAIIIFT 283
Cdd:COG2807 213 RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAaTAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 284 IGMFILSQAQTSFWFLGAgMLIGLGYGTLIPSFQTIAISAAPNHRR-GSATATYFSFFDSGIGFGSFILGIVAAKSSYHN 362
Cdd:COG2807 293 AGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSWT 371
|
330
....*....|....*
gi 447113062 363 MYFIAAIIVAFTLLL 377
Cdd:COG2807 372 AALLLLAALAVLMLV 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-174 |
5.42e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.43 E-value: 5.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFGAQ--SLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFI 168
Cdd:COG2271 262 LLLLALlpSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
....*.
gi 447113062 169 VCSVFS 174
Cdd:COG2271 342 LLAALA 347
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-360 |
6.62e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.85 E-value: 6.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 1 MQSEKLWTKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDL----GRKK 76
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 77 ------ILFISLSLFLAATVMYFGAQSLFL-LLALRFLHGIGFGMATTATGTIVTDVAP-AHRRGEALAYFGVFMSLPMV 148
Cdd:COG2211 82 pwiligAIPLALSFVLLFTAPDLSPTGKLIyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 149 IGPFLGLTIISHFS------FTVLFIVCSVFSLLAFLLGLLVdiPHEAPVSKQKREKMK--WKDLIEPSS-IPIALTGFV 219
Cdd:COG2211 162 LASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFG--TKERPVPEEEKVSLKesLKALLKNRPfLLLLLAYLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 220 LAFSYSGILSFIPIYAKE-LGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGM--FILSQAQTS 295
Cdd:COG2211 240 FFLALALVAALLLYYFKYvLGLSAaLVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLllLFFLGPGNL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447113062 296 FWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGS---ATATYFSFFD----SGIGFGSFILGIVAAKSSY 360
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrREGLYFGIFTfaikLGQALAGALAGLLLALFGY 391
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
7-373 |
1.77e-11 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 65.33 E-value: 1.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 7 WTKDFLGTCFSSLFLFLTFYMLMTTLPVYV----IDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISl 82
Cdd:PRK09874 12 WKRNLTVAWLGCFLTGAAFSLVMPFLPLYVeqlgVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRS- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 83 SLFLAATVMYFG-AQSLFLLLALRFLHGIGFGMATTATGTIVTDVaPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF 161
Cdd:PRK09874 91 ALGMGIVMVLMGlAQNIWQFLILRALLGLLGGFVPNANALIATQV-PRNKSGWALGTLSTGGVSGALLGPLAGGLLADSY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 162 SF-TVLFIVCSVFSLLAFLLGLLVDiPHEAPVSKqkREKMKWKDLIEPSSIP-----IALTGFVLAFSYSGILSFIPIYA 235
Cdd:PRK09874 170 GLrPVFFITASVLFLCFLVTLFCIR-ENFQPVSK--KEMLHMREVVTSLKNPklvlsLFVTTLIIQVATGSIAPILTLYV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 236 KELG-----LSEIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYG 310
Cdd:PRK09874 247 RELAgnvsnIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADG 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447113062 311 TLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAF 373
Cdd:PRK09874 327 ALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLF 389
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-164 |
7.15e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.38 E-value: 7.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA 88
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 89 TVMYF--GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAH-------RRGEALAYFGVFMSLPMVIGPFLGLTIIS 159
Cdd:COG2211 308 LLLLFflGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
....*
gi 447113062 160 HFSFT 164
Cdd:COG2211 388 LFGYV 392
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
48-174 |
9.11e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 59.59 E-value: 9.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 48 GLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVA 127
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447113062 128 PAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS 174
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILA 127
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
8-172 |
1.82e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.82 E-value: 1.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 8 TKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 88 ATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSL-----PMVIGPFLGLTIISHFS 162
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLgqflsPLVLGPLVNLTGGLSGA 355
|
170
....*....|
gi 447113062 163 FTVLFIVCSV 172
Cdd:cd17473 356 FLILGVLALV 365
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
44-377 |
7.25e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.91 E-value: 7.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17365 33 PAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFllgllvdipheapvskqkrekmkwk 203
Cdd:cd17365 113 SEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 204 dLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLS-EIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIF 282
Cdd:cd17365 168 -PLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSlSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 283 TIGMFILSQAQTSFWFLGAgmlIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSfFDSGIGFGSFILG------IVAA 356
Cdd:cd17365 247 AVSLALLGVSPASLVLLYV---LVFLAGACVNGAQVGLYALAARFYPTEVRATGVG-WALGVGRLGAILGpllgglLLAA 322
|
330 340
....*....|....*....|.
gi 447113062 357 KSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17365 323 GLGPESVFLALAIPAALGALA 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-372 |
9.71e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.51 E-value: 9.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 34 VYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFG 113
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 114 MATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLlvdipheapvs 193
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 194 kqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIPIY-AKELGLSEIASYFF-ILYALVVVISRPFTGKIFDRFGE 271
Cdd:cd17319 176 -----------FYLRQVWGLALGYFGINYALYGLLTWLPTYlKQARGFSLKQVGLLaAIPFLAGAIGMILGGRLSDRLLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 272 NVLVYPAIIIF--TIGMFILSQAQTSFWFLGAGMLIGL-GYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGS 348
Cdd:cd17319 245 GARRLVIIIGLllAAVGLLLAYLTTSPVVAVILLSLAGfGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAP 324
|
330 340
....*....|....*....|....
gi 447113062 349 FILGIVAAKSSYHNMYFIAAIIVA 372
Cdd:cd17319 325 LLIGYLVDATGSYTAAFLFLAAVA 348
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
213-382 |
1.21e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLS-EIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALPSIAADLGASsAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:COG0477 99 APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG 178
|
170
....*....|.
gi 447113062 372 AFTLLLYYGLH 382
Cdd:COG0477 179 LLALVLRLRLP 189
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
70-379 |
1.30e-09 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 59.76 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 70 DDLGRKKILFISLSLFLAATVM-----YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMS 144
Cdd:pfam05977 70 DNFDRRKIMLAGQLLLALVSTLltllaGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYN 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 145 LPMVIGPFLGLTIISHF--SFTVLFIVCSVFSLLAFLLGLlvdiPHEAPVSKQKREKM------KWKdlIEPSSIPIA-- 214
Cdd:pfam05977 150 IARSVGPALGGVLLAAFgpAFTFALNALSYFAVIAALWRW----KRAAPASPLPRERIfgavraGLR--FTAMSRELRsv 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 215 -LTGFVLAFSYSGILSFIPIYAKELGLSEIASYFFILYALVV--VISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:pfam05977 224 lVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVgaILGALSLPRLRERLGSDRLVLLASVVTALVLLSLAL 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:pfam05977 304 APNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAAL 383
|
....*...
gi 447113062 372 AFTLLLYY 379
Cdd:pfam05977 384 LAGAAAGL 391
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-377 |
2.11e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.38 E-value: 2.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLP-VYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAAT 89
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPvLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 90 VMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT----V 165
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 166 LFIVCSVFSLLAFllgllvdipheapvskqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIP-IYAKELGLSEIA 244
Cdd:cd17316 161 LFLIGALPALLAL--------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPtYLQTVLGLSPAT 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 245 SYFFILYALVV-VISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQA--QTSFWFLGAGMLIGLGYGTLIPSFQTIAI 321
Cdd:cd17316 215 SSLYLLLISLGaLVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLA 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447113062 322 SAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17316 295 ELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
46-376 |
2.71e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 58.49 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:cd17333 32 DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 126 VAPaHRRGEALAYFGVFMSLPMVIGPFLGLTII-SHFSFTVLFIVCSVFSLLAFLLGLLVDIPHEAPVS-KQKREKMKWK 203
Cdd:cd17333 112 LFE-ESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARnPQQSVGAFSA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 204 DLIEPSSIPIALTGFVLAFSYSG----ILSFIPIYAKELGLS--EIASYFFILYALVVVISRPFTGKIFDRFGENVLVYP 277
Cdd:cd17333 191 SASRLLRNPSIILGALALFLYVGaetaFSSWVPSYLVEKKHVsdGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 278 AIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPnHRRGSATATYFSFFDSGIGFGSFILG-IVAA 356
Cdd:cd17333 271 SGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGfIAEA 349
|
330 340
....*....|....*....|
gi 447113062 357 KSSYHNMYFIAAIIVAFTLL 376
Cdd:cd17333 350 VGIQTAMLLITILYAIIFVL 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
6-161 |
7.45e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 7.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 6 LWTKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLF 85
Cdd:cd17321 165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447113062 86 LAATVMYFGAQSLFLLLALRFLH---GIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF 161
Cdd:cd17321 245 AVGLLLLALLGADSSVWLLLPGLvllGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-174 |
7.67e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 57.05 E-value: 7.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLD-DLGRKKILFISLSLFLA 87
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 88 ATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFL-GLTIISHFSFTVL 166
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLaGFLLAATFGLTGA 362
|
....*...
gi 447113062 167 FIVCSVFS 174
Cdd:cd06174 363 FLVLAVLL 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-173 |
1.08e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.47 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17329 202 FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:cd17329 282 VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIL 361
|
...
gi 447113062 171 SVF 173
Cdd:cd17329 362 AAL 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-174 |
1.82e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.66 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 8 TKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 88 ATV-MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF-SFTV 165
Cdd:COG2223 284 GLLlLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTA 363
|
....*....
gi 447113062 166 LFIVCSVFS 174
Cdd:COG2223 364 AFLVFAVLA 372
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
19-382 |
2.60e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 55.28 E-value: 2.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 19 LFLFLTFYMLMTTLPVYVID-GLKgkPEEIGLVATVFLISSVLCRPFTGKWLDDLG-RKKILFISLSLFLAATVMYFGAQ 96
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQlGLS--PTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 97 SLFLLLALRFlhgIGFGMATTATGTIVTDVAPAHRRGEALAYFGV--FMSLPMVIGPFLGLTIISHFS----FTVLFIVC 170
Cdd:cd17335 85 QIFWLLLLLV---ILGAFFSAPVVPLVDSITLQYLGEERERYGKQrlWGSIGFGIAALLVGILIDRSStyknYTIAFYVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 171 SVFSLLAFLLGLLVDIPheapvSKQKREKMKWKDLIE----PSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSEIA-S 245
Cdd:cd17335 162 AVLMLLALLLALKFPFR-----PKHPEPNENTGGLLAllrnPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLiG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 246 YFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAP 325
Cdd:cd17335 237 LLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAP 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113062 326 NHRRGSATATYFS-FFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYGLH 382
Cdd:cd17335 317 PGLRATAQGLLQGlYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
213-377 |
1.16e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.33 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSEIA-SYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQlQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
....*.
gi 447113062 372 AFTLLL 377
Cdd:cd17321 161 LVALLL 166
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
251-377 |
1.39e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.96 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 251 YALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRG 330
Cdd:cd17503 40 YLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRG 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447113062 331 SATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17503 120 AAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
213-379 |
1.40e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.40 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSEIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQA 292
Cdd:cd06179 3 LCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 293 QTSFWFLGAGMLIGLGYGTlIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKS--SYHNMYFIAAII 370
Cdd:cd06179 83 KSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIF 161
|
....*....
gi 447113062 371 VAFTLLLYY 379
Cdd:cd06179 162 NALALILLF 170
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
218-377 |
2.95e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 52.23 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 218 FVLAFSYSGILSFIPIYAKELG------LSEIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:PRK09874 24 FLTGAAFSLVMPFLPLYVEQLGvtghsaLNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLgYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:PRK09874 104 AQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVL 182
|
....*.
gi 447113062 372 AFTLLL 377
Cdd:PRK09874 183 FLCFLV 188
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
20-299 |
3.43e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.84 E-value: 3.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 20 FLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISlslFLAATVMYFGAQSLF 99
Cdd:cd17331 10 VLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLS---FLSSALSYLLLAFAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 100 LLLALRFLHGIGFGMAT-TATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSF-------TVLFIVCS 171
Cdd:cd17331 87 SVPMLFLSRLPSVFMHAmQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEqaaalvaAVGSLLSI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 172 VFSLLAFLLGLLVDIPHEAPVSKQKREKMKWKDLIE----PSSIPIALTGFVLAFSYSGILSFIPIYAKE---LGLSE-- 242
Cdd:cd17331 167 VLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRllrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDffgLTPEEng 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113062 243 -IASYFFILYALVVVISRPFTGKifdRFGENVLVYPAIIIFTIGMFILSQAQTSFWFL 299
Cdd:cd17331 247 yLMSYAGVLGMVVQGLLVGPLTK---RFGERSLLKLSVALLAIGYLLLAFVTTVWQLL 301
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
231-378 |
3.92e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 51.41 E-value: 3.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 231 IPIYAKELGLSEIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYG 310
Cdd:cd17502 19 LPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGG 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447113062 311 TLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLY 378
Cdd:cd17502 99 GLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL 166
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
211-379 |
1.32e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.85 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 211 IPIALTGFVLAFSYSGILSFIPIYAKELGLSEIASYFFIL-YALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFIL 289
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFaFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 290 SQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRgSATATYFSFFDSGIGFGSFILGIVAAKS---SYHNMYFI 366
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA-SRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYLI 169
|
170
....*....|...
gi 447113062 367 AAIIVAFTLLLYY 379
Cdd:COG0738 170 LAVLLLLLALLFL 182
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
11-375 |
2.94e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.84 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDglkgkPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLD-----EAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT----VL 166
Cdd:cd17371 80 LCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiawrVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 167 FIVCSVFSLLAFLLGLLVDIPHEAPVSKQKREKMKWKDLI----EPSSIPIALTGFVLA----FSYSGILSFIPIYAK-E 237
Cdd:cd17371 160 FLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLrelfSPPLLRTTLLASLLAtgalGGYYGITTWLPSYLTgE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 238 LGLSEIASyffiLYALVVVISRPFTGKIF-----DRFGENvlvyPAIIIFTIG-------MFILSQAQTSFWFLGAgmLI 305
Cdd:cd17371 240 RGLSFEGS----AGYLVVTILGGFLGYLAggflaDRIGRR----NNFALFALGsaisillYFFLPLSPTLILILGF--PL 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447113062 306 GLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHN-------MYFIAAIIVAFTL 375
Cdd:cd17371 310 GFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTaiavfaaVYYIAGLVLALLL 386
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
227-377 |
3.07e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.89 E-value: 3.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 227 ILSFI-PIYAKELGLSEIASYFFILYALV-VVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGML 304
Cdd:TIGR00895 35 AMGFAaPAISAEWGLDPVQLGFLFSAGLIgMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFL 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447113062 305 IGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:TIGR00895 115 AGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLL 187
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
8-162 |
4.11e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 8 TKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447113062 88 ATVM---YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS 162
Cdd:cd17503 257 GTLLlafLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRT 334
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-355 |
4.70e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.14 E-value: 4.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:TIGR00881 31 DLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 126 VAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIIS-----HFSFTVLFIVCSVFSLLAFLLG---------------LLVD 185
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAelyswHWVFIVPGIIAIIVSLICFLLLrdspqscglppaeemPNEE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 186 IPHEAPVSKQKREKMK---WKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAK-ELGLS-EIASYFFILYALVVVISRP 260
Cdd:TIGR00881 191 PDGDAEKKEEELTKKQiflQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTqEKGFSkEKASWAFTLYELGGLVGTL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 261 FTGKIFDRFGEN-----VLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIG-LGYGTlIPSFQTIAISAAPNHRRGSATA 334
Cdd:TIGR00881 271 LAGWLSDKLFNGrrgplAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGfLVYGP-QMLIGVIASELAPKKAAGTAAG 349
|
330 340
....*....|....*....|..
gi 447113062 335 tYFSFFDSGIG-FGSFILGIVA 355
Cdd:TIGR00881 350 -FVGFFAYLGGiLAGLPLGYLA 370
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
18-379 |
4.86e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 48.15 E-value: 4.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 18 SLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQS 97
Cdd:TIGR00710 14 SILGPLGIDMYLPAFPEIAAD-LSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 98 LFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLA 177
Cdd:TIGR00710 93 IETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 178 FLLGLLVdIPHEAPVSKQKREKMKWKDLIEP-SSIPIALTGFVLAFSYSGILSFIP----IYAKELGLS-EIASYFFILY 251
Cdd:TIGR00710 173 SALIFFI-LPETLPYEARIQISTYFETFLLLlKSKMFWGYALIYGASFGGFFAFFSgapfVYIDIMGVSpSVFGLLFALN 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 252 ALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTS---FW--FLGAGMLIGLGYGTLIPSFQTIAISAAPn 326
Cdd:TIGR00710 252 IIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILglgSWamIIGPMMFVGIGNSMISSIAMAYALEDFP- 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 447113062 327 HRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:TIGR00710 331 HVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYY 383
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
44-357 |
6.57e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 47.74 E-value: 6.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:TIGR00895 51 PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALV 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS----------------------------- 174
Cdd:TIGR00895 131 SEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPlllllllmrflpesidflvskrpetvrri 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 175 LLAFLLGLLVDIPHEAPVSKQKRE------KMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELG--LSEIASY 246
Cdd:TIGR00895 211 VNAIAPQMQAEAQSALPEQKSTQGtkrsvfKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGfsLSLAATG 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 247 FFILYAlVVVISRPFTGKIFDRFGENVLVYPAIIIfTIGMFILSQAQTSF-WFLGAGMLIGLGYGTLIPSFQTIAISAAP 325
Cdd:TIGR00895 291 GALFNF-GGVIGSIIFGWLADRLGPRVTALLLLLG-AVFAVLVGSTLFSPtLLLLLGAIAGFFVNGGQSGLYALMALFYP 368
|
330 340 350
....*....|....*....|....*....|...
gi 447113062 326 NHRRGSATATYFsffdsGIG-FGSFILGIVAAK 357
Cdd:TIGR00895 369 TAIRATGVGWAI-----GIGrLGAIIGPILAGY 396
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
223-381 |
6.78e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 6.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 223 SYSGILS-FIPIYAKELGLS-EIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLG 300
Cdd:cd17478 10 FYQGFLPaLLPLLIAKLGLSyAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 301 AGMLIGLGYGTLIPSFQTIAISAAPNhRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYG 380
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR 168
|
.
gi 447113062 381 L 381
Cdd:cd17478 169 L 169
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
213-377 |
1.85e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.42 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAfsysgILSFI-PIYAKELGLSEIASYFFILYALV-VVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILS 290
Cdd:cd17365 8 IVLDGFDLA-----VMGFVaPALAQDWGLSPAQLGPVGSAALFgMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 291 QAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII 370
Cdd:cd17365 83 FAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVP 162
|
....*..
gi 447113062 371 VAFTLLL 377
Cdd:cd17365 163 PLILLPL 169
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-377 |
1.90e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.46 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFI-SLSLFLAATVMYFgAQSLFLLLALRFLHGIGFGMATTATGTIVT 124
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVgLLLMGAAALLMAL-VGSYPVLLVLLFLVGAGYGSVQPGGGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 125 DVAPAHRRGEALayfGVF-MSLPMviGPFLG----LTIISHFSFTVLFIVCSVFSLLAFLLGLLVDIPHEAPVSKQKREK 199
Cdd:cd17475 111 RWFPPRERGLAM---GIRqTGVPL--GGALAaallPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 200 MKWKDLIE----PSSIPIALTGFVLAFSYSGILSFIPIYAKE---LGLSEIASYFFILYALVVViSRPFTGKIFDRF--G 270
Cdd:cd17475 186 TLLRSLKEvlrnRDVWLIAIAGALLVAPQFALLTFLLLFLHDhlgLSVVAAGALLAVAQLGGAL-GRIGLGRVSDRVfgG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 271 ENVLVYPAIIIFTIGMFILSQ---AQTSFWFLGAGM-LIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGF 346
Cdd:cd17475 265 RRRPVLVITAAIAAAALLVLSllsPGTPLWLLVLLLiLLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAI 344
|
330 340 350
....*....|....*....|....*....|..
gi 447113062 347 GSFILG-IVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17475 345 GPPLFGlLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
12-174 |
2.28e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.03 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 12 LGTCFSSLFLFLTFYMLMTTLPVYVID----GLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 88 ATVMY-FGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS---- 162
Cdd:cd17504 260 GLLLLaLLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTvsit 339
|
170 180
....*....|....*....|.
gi 447113062 163 ---------FTVLFIVCSVFS 174
Cdd:cd17504 340 sggvptegaYVLAFLIGAALA 360
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
213-377 |
3.98e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 3.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQ 291
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTaLIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 292 AQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSsyHNMYFIAAIIV 371
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG--ALPFLIAAVLL 158
|
....*.
gi 447113062 372 AFTLLL 377
Cdd:cd17477 159 LLALVP 164
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
213-377 |
4.07e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSEIASYF----FILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFI 288
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYvgllQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 289 LSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPnHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAA 368
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDE-EERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
....*....
gi 447113062 369 IIVAFTLLL 377
Cdd:cd17330 160 ALALLNLVL 168
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
221-382 |
4.20e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.31 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 221 AFSYSGILSFIPIYAKELGLSEIASYFFI-LYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAqTSFWFL 299
Cdd:cd17475 9 SLVAQGIPALAPFLQEDLHLSLAQVGLLLsALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV-GSYPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 300 GAGM-LIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLY 378
Cdd:cd17475 88 LVLLfLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLF 167
|
....
gi 447113062 379 YGLH 382
Cdd:cd17475 168 WLFY 171
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
48-154 |
4.55e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 45.34 E-value: 4.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 48 GLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATgTIVTDVA 127
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVT 145
|
90 100
....*....|....*....|....*..
gi 447113062 128 PAHRRGEALAYFGVFMSLPMVIGPFLG 154
Cdd:cd17389 146 SPKKRSKGMALIGVAFSLGFIIGPMIG 172
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
251-377 |
6.30e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 45.06 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 251 YALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRG 330
Cdd:TIGR00711 46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRG 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447113062 331 SATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:TIGR00711 126 RAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVV 172
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
213-381 |
7.06e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 7.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 213 IALTGFVLAFSYSGILSFIPIYAKELGLSEIASYFFILYAlVVVISRPFTGKIF----DRFGENVLVYPAIIIFTIGMFI 288
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFA-AGFLGRPIGALLFgylgDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 289 LSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHN----MY 364
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwriLF 162
|
170
....*....|....*..
gi 447113062 365 FIAAIIVAFTLLLYYGL 381
Cdd:cd17316 163 LIGALPALLALLLRRRT 179
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
245-377 |
7.23e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 42.64 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 245 SYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAA 324
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 447113062 325 PNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
47-375 |
8.39e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 44.37 E-value: 8.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 47 IGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV--MYFGAQSLFLLLALRFLHG-IGFGMATTATGTIV 123
Cdd:COG2270 54 WGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATaaLFFVAPGGLWLGLLLFVLAnIGFEGSLVFYNAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TDVAPAHRRGE------ALAYFG----VFMSLPMVIGP-FLGLT---IISHFSFTVLFIVCSVFSLLAFLLGLLVDIPHE 189
Cdd:COG2270 134 PDIATPEEIGRvsglgwALGYLGgvllLLINLALFLKPeAFGLPdagEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 190 APVSKQKREKMK--WKDLIEPSSIPIALTgFVLAF-----SYSGILSFIPIYA-KELGLSEIA-SYFFILYALVVVISRP 260
Cdd:COG2270 214 APPRGAVRAGFRelRRTLRELRRYRDLLR-FLLAYffyrdGVQTVIAFAGIYAaGVLGFSTTElIVFGLLVQIVAALGAL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 261 FTGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSatatYFSFF 340
Cdd:COG2270 293 LFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAE----FFGLY 368
|
330 340 350
....*....|....*....|....*....|....*....
gi 447113062 341 D----SGIGFGSFILGIVAAKSSYHNmYFIAAIIVAFTL 375
Cdd:COG2270 369 AlsgkAASFLGPLLFGLVTQLTGSQR-LGILSLIVFFVI 406
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
43-354 |
8.66e-05 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 44.16 E-value: 8.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 43 KPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILfISLSLFLAAtVMYFGAQSLFLLLALRFLHGI-GFGMATTATGT 121
Cdd:pfam12832 32 NPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAV-VRLASILAA-VLFLSVLFIPISLTFWWLALLvVLFSFFWNAIL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 122 IVTDVAPAHRRGEALAYFG---VFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLV--DIPHEAPVSKQK 196
Cdd:pfam12832 110 PQFEVATLQHLGEKRKDYGrqrLWGSVGFALSVFGLGALFDHYSVGLLPSVLFYLFAALMLLSLLLplAPPEMEYESKGG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 197 REKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLV 275
Cdd:pfam12832 190 SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNtLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 276 YPAIIIFTIGMFILSQAQTSFWF-LGAGMLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSF-FDSGIGFGSFILGI 353
Cdd:pfam12832 270 IIALLLTALRWLLYAFFVENPWLvLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLyFGLGGALGSLIGGQ 349
|
.
gi 447113062 354 V 354
Cdd:pfam12832 350 L 350
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
44-323 |
1.11e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 44.13 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGrKKILFISLSLFLAATVMYFG----AQSLFLLLALR----FLHGIGFGMA 115
Cdd:cd17385 33 DTIIGLVFGCFALVIFLTSPIFGKYLVKIG-AKFMFVAGMFVSGGCTILFGfldrVPDGTVFIALCflvrIVEAVGFAAF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 116 TTATGTIVTDVAPAHRrGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVdIPHEAPVSKQ 195
Cdd:cd17385 112 ITASFAIIAKEFPNNI-ATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFI-LPRYDDDPSP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 196 KREKMkWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSEIA-SYFFILYALVVVISRPFTGKIFDR--FGEN 272
Cdd:cd17385 190 KSGSM-LKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPGQvGLMFLILAGSYAISAPLWGWLSDKkkIPKW 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113062 273 VLVYPAIIIfTIGMFILSQA-----QTSFWFLGAGM-LIGLGYG-TLIPSFQTIAISA 323
Cdd:cd17385 269 LMVIGSIIT-GVGFLLLGPApllpiKSELWMVIIGLvLLGLSLGaALVPTFPELLNCA 325
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
28-330 |
1.49e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.39 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 28 LMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLF-LAATVMYFgAQSLFLLLALRF 106
Cdd:cd17388 21 VLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAaLDYLLMAF-APTLWWLYLGRI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 107 LHGIGFGMATTATGTIVtDVAPAHRRGEALAYFGVFMSLPMVIGPFLGlTIISHFSFTVLFIVCSVFSLLAFLLGLLVdI 186
Cdd:cd17388 100 IAGITGATGAVAAAYIA-DVTPPEQRARNFGLLGAAFGLGFIAGPALG-GLLGEISPRAPFLVAAGLNGLNFLLGLFV-L 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 187 PHEAPvsKQKREKMKWKDLIEPSSI----------PIALTGFVLAFSYSGILSFIPIYAKE--------LGLSeiasyfF 248
Cdd:cd17388 177 PESLP--PERRRAFRWRRANPFGSLrwltgfpgllGLLAVFFLIQLIGQVPATTWVLFTEDrfdwsptmVGLS------L 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 249 ILYALVVVISRPF-TGKIFDRFGENVLVYPAIIIFTIGMFILSQAQTSFWFLGAGMLIGLGyGTLIPSFQTIAISAAPNH 327
Cdd:cd17388 249 AVFGLLHALFQAFvTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALG-GIAGPALQGLLSRQVPEN 327
|
...
gi 447113062 328 RRG 330
Cdd:cd17388 328 EQG 330
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
46-377 |
1.63e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.40 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:cd17393 35 ALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 126 VAPAHRRgEALAYFGVFMSLPMVIGPFLG-LTIISHFSFTVLFIVCSVFSLLAFLLGLLVDIPH---EAPVSKQKREKMK 201
Cdd:cd17393 115 VERAYGR-PIMSSLHAMWSLGGLAGALLGaAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGtgeAAEDRPDGAGKPG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 202 WKdLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGLSE-IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAI 279
Cdd:cd17393 194 FL-LPNRLLLLLGLLALAAALAEGAAADWSALYLRDvLGASAaLAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 280 IIFTIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPsfqtIAISAA---PNHRRGSATATYFSFFDSGIGFGSFILGIVAA 356
Cdd:cd17393 273 LLAALGLLLALLAPSVWVALAGFALMGLGLSVVVP----LAFSAAgalPGLAAGIAVARVATLGYLGFLVGPPLIGFLAD 348
|
330 340
....*....|....*....|.
gi 447113062 357 KSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17393 349 ATGLRTAFLVVALLALLVALL 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
9-173 |
2.15e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDL---GRKKILFISLSLF 85
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 86 LAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFL-GLTIISHFSFT 164
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDATGSYT 338
|
....*....
gi 447113062 165 VLFIVCSVF 173
Cdd:cd17319 339 AAFLFLAAV 347
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
46-377 |
2.73e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA-TVMYFGAQSLFLLLALRFLHGIGFGMA-TTATGTIV 123
Cdd:cd17353 39 SVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGfILSAFAISLPLLFLGYGVLGGIGAGIGyITPVSTAV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TdVAPAHR----------RGEALAYFGVFMSLPM----VIGPFLGLTIIshfsFTVLFIVCSVFSLLAFLLGLLVDIPHE 189
Cdd:cd17353 119 K-WFPDKRglatgiviagFGLGSLIFSPLIAYLIntvgVPTTFLILGII----FLIIIVIGAFLIRDPPKGWVPPGVDPL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 190 APVSKQKREKMKWKDLIE-PSSIPIALTGFVLAFSYSGILSFIPIYAKELGLSE--IASYFFILYALVVVISRPFTGKIF 266
Cdd:cd17353 194 ANNAENSPRDYTPREMLRtPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDagIAALAVSILSIFNGGGRPFWGWLS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 267 DRFGENVLVYPAIIIFTIGMFILSQAQ-TSFWFLGAGMLIGLGYGTLIPSFqtIAISAapnHRRGSAT-ATYFSFFDSGI 344
Cdd:cd17353 274 DKIGRKNTLSIAFLIQGVAMFLLPFIGsVAVLFVLGVALIGFCYGGGFALF--PALTA---DFFGTKNaGTNYGLLYTAK 348
|
330 340 350
....*....|....*....|....*....|....*..
gi 447113062 345 GFGSFILGIVAAK----SSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17353 349 GVGGLIGPIIAAYvlytGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
44-307 |
3.41e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.56 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17358 40 VAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 124 TDVAPAHRRGEalayFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLV------------------- 184
Cdd:cd17358 120 AEIAPKNVRGA----LGSLNQLLVNIGILLGYVLGSFLPWRTLALIGAIPPVVFLILLFFIpesprwlakkgreeeaeks 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 185 ---------DIPHEAPVSKQKREKMK-------WKDLIEPSSIPIALTGFVLAFSY--SGILSFIpIYA----KELGLSE 242
Cdd:cd17358 196 lqflrgkdaDISKEAAEIQEELAELEkeakessFSDLFQRKYLKPLVIGLGLMLFQqlSGINAVI-FYAssifDEAGSGL 274
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447113062 243 IASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFILSqaqTSFWFLGAGMLIGL 307
Cdd:cd17358 275 DPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALG---LYFYLQEHGALLSS 336
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
63-309 |
3.51e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 42.32 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 63 PFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYF-GV 141
Cdd:PRK10473 56 LFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLnGI 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 142 FMSLPmVIGPFLGLTIISHFSFTVLF-------IVCSVFSLLAFLLGLLVDIPHEAPVSKQKREKMKWKDLIEPSSIPIA 214
Cdd:PRK10473 136 TCIIP-VLAPVLGHLIMLKFPWQSLFytmaamgILVLLLSLFILKETRPARAPAASSKPRENSESLLNRFFLSRLVITTL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 215 ltgfvlafSYSGILSFIP----IYAKELGLS-EIASYFFILYALVVVISRPFTGKIFDRFGENVLVYPAIIIFTIGMFIL 289
Cdd:PRK10473 215 --------SVTVILTFVNtspvLLMEQMGFSrGEYAIIMALTAGVSMTVSFSTPFALGIFKPRTLMLTSQVLFLAAGITL 286
|
250 260
....*....|....*....|
gi 447113062 290 SQAQTSFWFLGAGMLIGLGY 309
Cdd:PRK10473 287 ALSPSHAVSLFGITLICAGF 306
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
39-174 |
4.14e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.18 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 39 GLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTA 118
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113062 119 TGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS--FTVLFIVCSVFS 174
Cdd:cd17315 108 VPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPA 165
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
222-379 |
5.70e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.79 E-value: 5.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 222 FSYSGILSFIPIYAKE---LGLSEIASYFFI-LYALVVVISRPFTGKIFDRF-GENVLVYPAIIIFTIGMFILSQAQTSF 296
Cdd:cd17346 16 FSYYGMRAILILYLTAqlgDGFSEADAASIYgAYTALVYLTPIIGGWLADKVlGARRTVFIGGILMALGYLLLALSPFSV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 297 WFLGAGM-LIGLGYGTLIPSFQTI--AISAAPNHRRGSAtatyFSFFDSGIGFGSF----ILGIVAAKSSYHNMYFIAAI 369
Cdd:cd17346 96 SMLYLGLaLIIVGNGLFKPNISSLvgKLYDENDPRRDSG----FSIFYMGINLGAFlaplLCGTLGDNYGYHYGFGLAAV 171
|
170
....*....|
gi 447113062 370 IVAFTLLLYY 379
Cdd:cd17346 172 GMLLGLLIFL 181
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
15-174 |
6.75e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.46 E-value: 6.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 15 CFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIG-----LVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAAT 89
Cdd:cd17313 246 WWIAFFPFELFFTDYMGEEVYHGTSAASSHYGAGvrmgaWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGM 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 90 VMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRR--GEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLF 167
Cdd:cd17313 326 ALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVF 405
|
....*..
gi 447113062 168 IVCSVFS 174
Cdd:cd17313 406 PVAAVAS 412
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
6-173 |
7.10e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 7.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 6 LWTKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCR-PFTGKWLDDLGRKKILFISLSL 84
Cdd:cd17330 171 FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 85 FLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT 164
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG 330
|
....*....
gi 447113062 165 VLFIVCSVF 173
Cdd:cd17330 331 VPFLLAAGL 339
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
15-172 |
7.28e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.44 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 15 CFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDL-GRKKILFISLSLFLAATVMYF 93
Cdd:cd17331 213 LLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRfGERSLLKLSVALLAIGYLLLA 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447113062 94 GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSV 172
Cdd:cd17331 293 FVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAA 371
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
11-173 |
1.90e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGkWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17352 185 FVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLG-LLADKPRIGRLYLYIFTLLILGL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 91 MYFG---AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIG-PFLGLTIISHFSFTVL 166
Cdd:cd17352 263 SLLAfplATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGpPIAGLLRDYTGDYDAA 342
|
....*..
gi 447113062 167 FIVCSVF 173
Cdd:cd17352 343 FYFCGAC 349
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
22-173 |
1.90e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 39.90 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 22 FLTFYMLMTTLPVYvIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLL 101
Cdd:cd17390 9 LFGVSMILPLLSTH-IRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALL 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447113062 102 LALRFLHGIgFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLG--LTIISHFSFTVLFIVCSVF 173
Cdd:cd17390 88 FLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGghLAETDGGFYYVALLCSAIF 160
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
46-154 |
3.32e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 39.26 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:cd17362 40 QSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAE 119
|
90 100
....*....|....*....|....*....
gi 447113062 126 VAPAHRRGEALAYFGVFMSLPMVIGPFLG 154
Cdd:cd17362 120 TSPSHIRGLLVSLKELFIVLGILLGYVSG 148
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
228-350 |
3.48e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.41 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 228 LSFIPIYAKELGLSEI-ASYFFILYALVVVISRPFTGKIFDRFG-ENVLVYPAII--IFTIGMFILSQAQTSFWF-LGAG 302
Cdd:cd17337 17 QGFLSPYLVDLGFSEAqAALLFTVYGLTVAIASWLSGVLAELFGpRRVMLIGLIIwlVFEVLFLAFGLPSHNYPLmLLTY 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 447113062 303 MLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIG-FGSFI 350
Cdd:cd17337 97 GLRGFGYPLFAYSFLVWITYRTPAERLGSAVGWFWFAFTGGLPvLGSYL 145
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
48-133 |
4.82e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.70 E-value: 4.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 48 GLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVA 127
Cdd:cd17359 39 GLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVA 118
|
....*.
gi 447113062 128 PAHRRG 133
Cdd:cd17359 119 PAEIRG 124
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-373 |
5.14e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 16 FSSLFLFLtFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSV---LCRPFTGKWLDDLGRKKILFISLSLFLAA-TVM 91
Cdd:cd17314 7 VSFLLSAM-STGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLgmlLTQPILGFIADSFGPRPLMALAGIMVLAGyTYL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 92 YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPaHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSF--TVLFIV 169
Cdd:cd17314 86 SYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLalVYTILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 170 CSVFSLLAFLLGLLVDIPHEAPVSKQKREKmKWKDLIEPSSIPIALTGFVLAFSYS-GILSFIPIYAKELGLSEIASYFF 248
Cdd:cd17314 165 ILAAIVLSVVSLLGFKEPPDNQARLHVQKK-KTQTMGEIFRDKVFWILFIAIFLVLiGGFLFIANMASLVRSLQLDAPSF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 249 I-----LYALVVVISRPFTGKIFDRFGENVLVYPAIIIF---TIGMFILSQAQTSFWFLGAGMLIGLGYGTLIPSFQTIA 320
Cdd:cd17314 244 VtklmsIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTIlglGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATV 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 447113062 321 ISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAF 373
Cdd:cd17314 324 STVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVF 376
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
11-127 |
5.49e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 5.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKwLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17332 223 FLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPL-KKRFGKKKAFFIGLLLAILGLL 301
|
90 100 110
....*....|....*....|....*....|....*....
gi 447113062 91 MYF--GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVA 127
Cdd:cd17332 302 LLFflPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVI 340
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-173 |
5.64e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 5.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113062 23 LTFYMLMTTLPVYVIDgLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLL 102
Cdd:cd17478 209 WVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYI 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447113062 103 ALRFLhGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLtIISHFSFTVLFIVCSVF 173
Cdd:cd17478 288 LLVLA-GFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGA-LADAFGLESVLLILALL 356
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
19-93 |
7.23e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 38.11 E-value: 7.23e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447113062 19 LFLFLTFYMLMTTLPVYVIDGLKGKPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYF 93
Cdd:cd17366 203 LVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAF 277
|
|
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