|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-378 |
7.94e-103 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 308.75 E-value: 7.94e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 15 CFSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 95 AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS 174
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 175 LLAFLLGLLVNIPHEAPVKKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLADiASYFFIVYALV 254
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN-AGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 255 VVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATA 334
Cdd:cd17489 240 LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 447113088 335 TYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLY 378
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-379 |
4.36e-54 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 183.55 E-value: 4.36e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 15 CFSSLFLFLTFYMLMTTLPVYViDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 95 AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 175 LLAFLLGLLV-----NIPHEAPVKKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLADIA--SYF 247
Cdd:cd17325 161 LLALVLALLLlpeprPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqiGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 248 FIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNH 327
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447113088 328 RRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-344 |
4.29e-45 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 158.98 E-value: 4.29e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 171 SVFSLLAFLLGLLVnIPHEAPVKKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGL-ADIASYFF 248
Cdd:COG2814 171 AVLALLALLLLLRL-LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLsASAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 249 IVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHR 328
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....*.
gi 447113088 329 RGSATATYFSFFDSGI 344
Cdd:COG2814 330 RGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-348 |
4.77e-39 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 142.94 E-value: 4.77e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 14 TCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYF 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 94 GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVF 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 174 SLLAFLLGLLVNIPHEAPVKKQKREK-----MKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLADIASYFF 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEArlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 249 I-VYALVVVISRPFTGKIFDRYGEN---VLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAA 324
Cdd:pfam07690 241 LgLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 447113088 325 PNHRRGSATATYFSFFDSGIGFGS 348
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-379 |
1.80e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 111.89 E-value: 1.80e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPvYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILP-AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLG--LTIISHFSFTVLFI 168
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGglLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 169 VCSVFSLLAFLLGLLVNIPHEAPVKKQKREKMKwKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKEL--GLADIASY 246
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDLK-KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLygISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 247 FFIVYALVVVISRPFTGKIFD-RYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAP 325
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447113088 326 NHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-387 |
5.11e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 110.34 E-value: 5.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 15 CFSSLFLFLTFYMLMTTLPV---YVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVM 91
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVaapPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 92 YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCS 171
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 172 VFSLLAFLlgllvnipheapvkkqkrekmkwkdliePSSIPIALTGFVLAFSYSGILSFIPIYAKELGLADI--ASYFFI 249
Cdd:COG2271 172 LPGLLLAL----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLaqAGLLLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 250 VYALVVVISRPFTGKIFDRYGENVLVYPAI--IIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNH 327
Cdd:COG2271 224 LPFLAGIVGSLLGGWLSDRLGRRRKLVLAIglLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 328 RRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYGLHGRKQK 387
Cdd:COG2271 304 ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
16-381 |
3.93e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 108.08 E-value: 3.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 96 QSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIIShFSFTVLFI---VCSV 172
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLaaaVLFL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 173 FSLLAFLLGLLVNIPHEAPVKKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGL--ADIASYFFIV 250
Cdd:cd17329 165 LAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGlgESLLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 251 YALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRG 330
Cdd:cd17329 245 NALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRG 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 447113088 331 SATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYGL 381
Cdd:cd17329 325 SYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-379 |
1.90e-25 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 106.16 E-value: 1.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFIS-----LSLFLAATV 90
Cdd:cd06173 6 LAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:cd06173 85 ALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 171 SVFSLLAFLLGLLvnIPHEAPVKKQKREKMKWKDLIE--------PSSIPIALTGFVLAFSYSGILSFIPIYAKELGLAD 242
Cdd:cd06173 165 ALSFLLSALLLLF--IRRPPPAAPGESSSLLLRDLREglrylrrsPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 243 IASYFFI--VYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIA 320
Cdd:cd06173 243 AAGYGLLlaAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLL 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447113088 321 ISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd06173 323 QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-356 |
5.68e-25 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 104.56 E-value: 5.68e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 14 TCFSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYF 93
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARD-LGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 94 GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVF 173
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 174 SLLAFllgllvnipheapvkkqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGL-ADIASYFFIVY 251
Cdd:cd17321 160 GLVAL--------------------------LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYsPLQAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 252 ALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALS--QAQTPFWFLSAG-VLIGLGYGTLIPSFQTIAISAAPNHR 328
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllGADSSVWLLLPGlVLLGLGLGLFATPLTNAALSSVPKEK 293
|
330 340
....*....|....*....|....*...
gi 447113088 329 RGSATATYFSFFDSGIGFGSFILGIVAA 356
Cdd:cd17321 294 AGAASGILNTARQLGGALGVALLGALLT 321
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
16-377 |
1.57e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 103.40 E-value: 1.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLTFYMLMTTLPVyVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:cd17324 6 LAAFAIGTTEYVIQGLLPD-IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 96 QSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSL 175
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 176 LAFLLGLLV--NIPHEAPVKKQKReKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKEL--GLADIASYFFIVY 251
Cdd:cd17324 165 LAALLLWRLlpSLPPKKPGSLGLL-SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpgFSSSAIIGLLLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 252 ALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHrRGS 331
Cdd:cd17324 244 GVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447113088 332 ATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17324 323 ASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-387 |
7.29e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 96.10 E-value: 7.29e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLTFY--MLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYF 93
Cdd:COG2223 9 LATLAFFLAFGvwYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 94 GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVF 173
Cdd:COG2223 89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 174 S--LLAFLLGLLVNIPHEAPVKKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE---LGLADIASYFF 248
Cdd:COG2223 169 LlvVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqfgLSAATAGLLAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 249 IvYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFW-FLSAGVLIGLGYGTLIPSFQTIAISAAPNH 327
Cdd:COG2223 249 L-FALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWlFLVLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447113088 328 RRGSATATYFSFFDSGIGFGSFILG-IVAAKSSYHNMYFIAAIIVAFTLLLYYGLHGRKQK 387
Cdd:COG2223 328 NAGAVYGLVGAAGGLGGFLGPLLFGaLLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-174 |
3.28e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.18 E-value: 3.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA 88
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 89 TVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFI 168
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
....*.
gi 447113088 169 VCSVFS 174
Cdd:cd17325 359 AAAALL 364
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
18-378 |
8.66e-21 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 93.03 E-value: 8.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 18 SLFLFLTFY---MLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:PRK05122 21 VMFTFISYLtigLPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 95 AQ--------SLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVL 166
Cdd:PRK05122 101 AGllaawpvlSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 167 FIVCSVFSLLAFLLGLLVnipheAPVKKQKREKMKWKDLIEPssipIALTGFVLAFS---YSGILSFIPIYAKELGLADi 243
Cdd:PRK05122 181 GLLIMLLALLGLLLARPR-----PAVPPVKGERLPFRRVLGR----VWPYGMGLALAsigFGTIATFITLYYAARGWDG- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 244 ASYFFIVYALVVVISRPFTGKIFDRY-GENVlvypAIIIF---TIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTI 319
Cdd:PRK05122 251 AALALTLFGVAFVGARLLFGNLINRLgGLRV----AIVSLlveILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447113088 320 AISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII----VAFTLLLY 378
Cdd:PRK05122 327 AVKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAallgLALTWLLY 389
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-390 |
1.31e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 92.61 E-value: 1.31e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:COG0738 44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 126 VAPAHRRGeALAYFGVFMSLPMVIGPFLGLTIISH---FSFTVLFIVCSVFSLLAFLLGLLVNIPHEAPVKKQKREkmKW 202
Cdd:COG0738 124 LGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG--SA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 203 KDLIEPSSIPIALTGFVLAFSYSG----ILSFIPIYAKE-LGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVY 276
Cdd:COG0738 201 ASLKSLLKNPRLLLGGLAIFLYVGaegaIGDWLPLYLKDvLGLsEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 277 PAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHrRGSATATYFSFFDSGIGFGSFILGIVAA 356
Cdd:COG0738 281 LSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLAD 359
|
330 340 350
....*....|....*....|....*....|....
gi 447113088 357 KSSYHNMYFIaaIIVAFTLLLYYGLHGRKQKFKK 390
Cdd:COG0738 360 AFGLRAAFLV--PLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
16-377 |
1.50e-20 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 91.85 E-value: 1.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 96 QSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLgLTIISHFSFTvLFIVCSVFSl 175
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGAL-PFLIAAVLL- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 176 laFLLGLLVNIPHEAPVKKQKREKMKWKDLIepSSIPIALTG-FVLAFSYSGILSFIPIYAKELGL-ADIASYFFIVYAL 253
Cdd:cd17477 159 --LLALVPLLLTRRAAPEIEEAESISLRRLL--RIAPLALLGaFVAGFLEGAFYSLLPLYGLRLGLsVAQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 254 VVVISRPFTGKIFDRYG-ENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSA 332
Cdd:cd17477 235 GGLLLQWPLGWLADRFDrRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447113088 333 TATYFSFFDSGIGFGSFILGIVAAKSSYHNM-YFIAAIIVAFTLLL 377
Cdd:cd17477 315 NAALLLLYGLGSVIGPLLAGALMDAFGPHGLfLFLAAVALLFLLFL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-379 |
1.63e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.10 E-value: 1.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 15 CFSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFG 94
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 95 AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT---------V 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwravfliaaA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 166 LFIVCSVFSLLAFLLGLLVNIPHEAPVKKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELG--LADI 243
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGglSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 244 ASYFFIVYALVVVISRPFTGKIFDRY-GENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAIS 322
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113088 323 AAPNHRRGSATATYFSFFDSGIGFGSFILGIV-AAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-379 |
3.58e-20 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 91.10 E-value: 3.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 40 LKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTAT 119
Cdd:cd17473 30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 120 GTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLG---LTIISHFSFTV--LFIVCSVFSLLAfllgllvnIPHEAPVKK 194
Cdd:cd17473 110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGgalAEIGWRAPFLVylLALPVLILVLLF--------LPEPARKSK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 195 QKRE--KMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLAD--IASYFFIVYALVVVISRPFTGKIFDRYG 270
Cdd:cd17473 182 SAASpgAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSaaLIGLALAIASLAGAIGALLFGRLKRRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 271 ENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFI 350
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|
gi 447113088 351 LG-IVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17473 342 LGpLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-377 |
1.03e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 89.56 E-value: 1.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 27 MLMTTLPVyVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRF 106
Cdd:cd17504 14 MLSPALPT-IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 107 LHGIGFGMATTATGtIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVNI 186
Cdd:cd17504 93 LQGIGGAVFPLAFA-LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 187 pheapvkKQKREKMKWKdliepSSIPIALTGFVLAFSYSGILSFIPI-YAKELGLADIASYFFIV-YALVVVISRPFTGK 264
Cdd:cd17504 172 -------RLLRRRNVLL-----ANITALLAGFGMFMVFQLLPQLLQLpTPTGFGLGITEAGLLLLpGALVMLIAGPLAGR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 265 IFDRYGENVLVYPAIIIFTIGMFALS-QAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSG 343
Cdd:cd17504 240 LIARVGPRRVLLIGLVISAVGLLLLAlLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 447113088 344 IGFGSFILGIVAAKSS-------------YHNMYFIAAIIVAFTLLL 377
Cdd:cd17504 320 SAIGPAIAGAILTTYTvsitsggvptegaYVLAFLIGAALALAALLL 366
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
44-354 |
1.27e-19 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 89.56 E-value: 1.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17503 30 LDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTIL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVNIpheapvkkqkrekmkwK 203
Cdd:cd17503 110 LRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLDL----------------R 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 204 DLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIII 281
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYsAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447113088 282 FTIGMFALSQ--AQTPFWFLS-AGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIV 354
Cdd:cd17503 254 LALGTLLLAFltPDTSLWLIIlPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
16-377 |
2.66e-19 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 88.58 E-value: 2.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGA 95
Cdd:PRK12382 22 FAVFLTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGLAYLLA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 96 ---QSLFLLLALRFLHG---IGFGMATTATGTI---VTDVAPAHRrGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVL 166
Cdd:PRK12382 102 ailPVSAPFKFALLVVGrliLGFGESQLLTGALtwgLGLVGPKHS-GKVMSWNGMAMYGALAAGAPLGLLLHSHFGFAAL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 167 FIVCSVFSLLAFLLGLLVnipheAPVKKQKREKMKWKDLIEPssipIALTGFVLAFS---YSGILSFIPIYAKELGLADi 243
Cdd:PRK12382 181 ALTTMVLPLLAWAFNGTV-----RKVPAHAGERPSLWSVVGL----IWKPGLGLALQgvgFAVIGTFVSLYFASKGWAM- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 244 ASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISA 323
Cdd:PRK12382 251 AGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKR 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 447113088 324 APNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:PRK12382 331 VPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIV 384
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
13-377 |
1.95e-18 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 85.71 E-value: 1.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 13 GTCFSSLFLFLTFYmlmttlpVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMY 92
Cdd:cd17330 9 ALGFGIVFPVLPFY-------VREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 93 FGAQSLFLLLALRFLHGIgFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSV 172
Cdd:cd17330 82 GLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 173 FSLLAFLLGLlvnipheapvkkqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIPIYAK---ELGLADIASYFFI 249
Cdd:cd17330 161 LALLNLVLVL----------------------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKdrfGFSPSQIGLLLAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 250 VYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRR 329
Cdd:cd17330 219 VGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQ 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 447113088 330 GSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17330 299 GKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-174 |
4.81e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 84.57 E-value: 4.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLkgrPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA 88
Cdd:cd17489 194 KKVLPPALILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 89 TVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFI 168
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFL 350
|
....*.
gi 447113088 169 VCSVFS 174
Cdd:cd17489 351 LAAVVV 356
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
47-377 |
2.68e-17 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 82.23 E-value: 2.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 47 IGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDV 126
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 127 APAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIvcsvfsllafllgllVNIPHEAPVKkqkrekmkwkdLI 206
Cdd:cd17502 112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY---------------INLPIGGLAL-----------AL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 207 EPSSIPIALTGFVLAFSYSGILSFIPIYAKE-LGL-ADIASYFFIVYALVVVISRPFTGKIFDRYG-ENVLVYPAIIIFT 283
Cdd:cd17502 166 LRTILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDsATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 284 IGMFALSQ--AQTPFWFLS-AGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATyFSFFDSgIGFGSFIlgivaaksSY 360
Cdd:cd17502 246 VGAGLLTTltLDTSKWLLIgYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATAT-NTFFRS-LGGTLGV--------AI 315
|
330
....*....|....*..
gi 447113088 361 HNMYFIAAIIVAFTLLL 377
Cdd:cd17502 316 TDVFLVALALAALAFLL 332
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
22-376 |
9.81e-17 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 80.72 E-value: 9.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 22 FLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVF-LISSVLCRPFtGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFL 100
Cdd:cd17472 9 MLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYgLTQAIFQIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 101 LLALRFLHGIGfgmATTATGT-IVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFL 179
Cdd:cd17472 88 LILGRALQGSG---AISSVVMaLLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 180 LGLLVnIPHEAPVK--KQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLAdiASYFFIVYALVVVI 257
Cdd:cd17472 165 ILLFF-VPDPPKIVqiSEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGG--KGQLWKVYLPAILI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 258 SRpFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ-----AQTPFWFLSAGVLIG-LGYGTLIPSFQTIAISAAPNHRRGS 331
Cdd:cd17472 242 GF-ILMVPFVIYAEKKGKMKQVFVSSILLIAVGFllllfAATSLWLLIIGLIIFfIGFNLLEALLPSLVSKIAPKEYRGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447113088 332 ATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLL 376
Cdd:cd17472 321 AMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
213-377 |
1.12e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.40 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ 291
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGAsPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 292 AQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
....*.
gi 447113088 372 AFTLLL 377
Cdd:COG2814 175 LLALLL 180
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-379 |
1.17e-16 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 80.73 E-value: 1.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 15 CFSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKIlFISLSLFLA--ATVMY 92
Cdd:cd17490 2 LIIVFLFWFSQYVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKL-FIIIGLLFTvlASLIM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 93 FGAQSLFLLLALRFLHGIGFGMATTATgTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSV 172
Cdd:cd17490 80 ILFPSPWGLLIARFLSGIAAATWVSFT-VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 173 FSLLAFLLGLLVNIPHEAPVKKQKREK-----MKWKDLIEPSsipiALTGFVLAFSYSGILSFIPIYAKELGLADIA-SY 246
Cdd:cd17490 159 AGVLGFILSLFIKEERREKKPVLTELKellsvLKDKKLLFFS----LLAILQQMITFSTTFGFTPLIAKQLGASSFQlGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 247 FFIVYALVVVISRPFTGKIF-DRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAP 325
Cdd:cd17490 235 LSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVP 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447113088 326 NHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII--VAFTLLLYY 379
Cdd:cd17490 315 AEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIalLAAILSLAY 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
16-379 |
2.17e-16 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 80.00 E-value: 2.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEI----GLVATVFLISSVLCRPFTGKWLDDLGRKKILF-ISLSLFLAATV 90
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLrASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFgAQSLFLLLALRFLHGIGFGMATTATGTIVTdVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:cd17391 83 MAF-VTNVWQLLILRLLQGVFSGYVPNATALIAS-QTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 171 SVFslLAFLLGLLVNIPHEA--PVKKQKREKMK--WKDLIEPSSI-PIALTGFVLAFSYSGILSFIPIYAKELG-----L 240
Cdd:cd17391 161 GGL--LFLAFLLTLFFVKEDfkPVEKKKMVSTKevWNSVPNPSLLiSLFVTTFIIQLANQSIEPILTLYIRQLMgdasnL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 241 ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIA 320
Cdd:cd17391 239 AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLL 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447113088 321 ISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSF 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
213-381 |
5.37e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 78.77 E-value: 5.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIYAKELGLAD-IASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ 291
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVaQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 292 AQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170
....*....|
gi 447113088 372 AFTLLLYYGL 381
Cdd:cd17325 161 LLALVLALLL 170
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
12-377 |
3.66e-15 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 76.04 E-value: 3.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 12 LGTCFSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVM 91
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 92 YFG-AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEAlayFGVFMSLPM---VIGPFL--GLTIISHFSFTV 165
Cdd:cd17370 81 LLAlAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKA---FGLHRALDTlgaVLGPLLaaLLLYLLGGNYRT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 166 LFIVCSVFSLLAFLLGLLVNIPHEAPVKKQ-KREKMKWKDLiePSSIPIALTG-FVLAFSYSGIlSFIPIYAKELGLADI 243
Cdd:cd17370 158 IFLLAAIPALLALLILLFVVKEYPRPPKLRkKSKKTSLKKL--PKAFWLYLLAvALFALGNFSF-AFLILRAQELGLSAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 244 -ASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAIS 322
Cdd:cd17370 235 lIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVAD 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 447113088 323 AAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17370 315 LVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
213-392 |
9.94e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.94 E-value: 9.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIYAKELGLADIASYFFI-VYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ 291
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVgLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 292 AQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180
....*....|....*....|.
gi 447113088 372 AFTLLLYYGLHGRKQKFKKQR 392
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEA 181
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
17-377 |
3.09e-14 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 73.35 E-value: 3.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 17 SSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLG-RKKILFIS-LSLFLAATVMYFG 94
Cdd:cd17471 4 ATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLAlLAGALGYLLFAFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 95 AQSLFLLLALRFLHGIGfGMATTATGTIVTDVAPAHRRGEALAYFGV---FMSLPMVIGPFLGLTIISHFSFTVLFIVCS 171
Cdd:cd17471 84 RNYWVLLLVGVVLLSLG-AAAFPQLFALAREYADRSSGRDATLFNSVlraAFSLAWVIGPPLAFLLLDVLGFTGLFLLAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 172 VFSLLAFLLGLLV--NIPHEAPVKKQKREKMKWKDliePSSIPIALTGFVLAF--SYSGILSfIPIY-AKELGL-ADIAS 245
Cdd:cd17471 163 LLYLVVALLVLFLlpSVKPPAQKATPASSLVKAPV---NRRLLLLFAAFTLLFaaNSMYIIA-MPLYvTNELGGsESWVG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 246 YFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTlipsFQTIAISAAP 325
Cdd:cd17471 239 LLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGI----TAGLGISYFQ 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 447113088 326 N---HRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17471 315 DlmpGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-381 |
6.78e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 72.61 E-value: 6.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17320 33 ASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVnIPHEAPVKKQK-REKMKW 202
Cdd:cd17320 113 RDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF-LPETLPEEKRKpLLSSLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 203 KDLIEPSSIPIALT-GFVLAFSYSGILSFIP----IYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVY 276
Cdd:cd17320 192 RAYKRVLKNRRFLGyALALGLSFAGLFAYLAaapfIYIEQLGLsPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 277 PAIIIFTIGMFALS-----QAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPnHRRGSATATYFSFFDSGIGFGSFIL 351
Cdd:cd17320 272 LGLLLLLAAALVLLlaallGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALV 350
|
330 340 350
....*....|....*....|....*....|
gi 447113088 352 GIVAAkSSYHNMYFIAAIIVAFTLLLYYGL 381
Cdd:cd17320 351 GLLPN-GTALPMGLLILVLGLLALLLLILL 379
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-290 |
1.19e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.00 E-value: 1.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPVYViDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 171 SVFSLLAFLLGLLVNIPHEAPVKKQKREKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLADIASYFFIV 250
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 447113088 251 YALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALS 290
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
7-373 |
1.45e-13 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 71.49 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 7 WTKDFLGTCFSSLFLFLTFYMLMTTLPVYV----IDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISl 82
Cdd:PRK09874 12 WKRNLTVAWLGCFLTGAAFSLVMPFLPLYVeqlgVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRS- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 83 SLFLAATVMYFG-AQSLFLLLALRFLHGIGFGMATTATGTIVTDVaPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF 161
Cdd:PRK09874 91 ALGMGIVMVLMGlAQNIWQFLILRALLGLLGGFVPNANALIATQV-PRNKSGWALGTLSTGGVSGALLGPLAGGLLADSY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 162 SF-TVLFIVCSVFSLLAFLLGLLVnipHEAPVKKQKREKMKWKDLIEPSSIP-----IALTGFVLAFSYSGILSFIPIYA 235
Cdd:PRK09874 170 GLrPVFFITASVLFLCFLVTLFCI---RENFQPVSKKEMLHMREVVTSLKNPklvlsLFVTTLIIQVATGSIAPILTLYV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 236 KELG-----LADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYG 310
Cdd:PRK09874 247 RELAgnvsnIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADG 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447113088 311 TLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAF 373
Cdd:PRK09874 327 ALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLF 389
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-377 |
2.10e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 70.66 E-value: 2.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 47 IGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDV 126
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 127 APaHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF---SFTVLFIVCSVFSLLAFLLGLLVnIPHEAPVKKQKREKMKWK 203
Cdd:cd17478 113 AG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFgglGLLILLIIPGLAVALLLLRLRPL-KKPEAKKAAAKSSARSTL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 204 DLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLADI-ASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIF 282
Cdd:cd17478 191 KGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVfAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 283 TIGMFALSQAQtPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHrRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHN 362
Cdd:cd17478 271 APFLLLFLLTP-GIWSYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLES 348
|
330
....*....|....*
gi 447113088 363 MYFIAAIIVAFTLLL 377
Cdd:cd17478 349 VLLILALLPLLGALL 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
213-379 |
2.97e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.06 E-value: 2.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIY-AKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALS 290
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGIsPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 291 QAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII 370
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
....*....
gi 447113088 371 VAFTLLLYY 379
Cdd:pfam07690 161 SLLAAVLLL 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-360 |
4.34e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.23 E-value: 4.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 1 MQSEKLWTKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDL----GRKK 76
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 77 ------ILFISLSLFLAATVMYFGAQSLFL-LLALRFLHGIGFGMATTATGTIVTDVAP-AHRRGEALAYFGVFMSLPMV 148
Cdd:COG2211 82 pwiligAIPLALSFVLLFTAPDLSPTGKLIyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 149 IGPFLGLTIISHFS------FTVLFIVCSVFSLLAFLLGLLVNipHEAPVKKQKREKMK--WKDLIEPSS-IPIALTGFV 219
Cdd:COG2211 162 LASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGT--KERPVPEEEKVSLKesLKALLKNRPfLLLLLAYLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 220 LAFSYSGILSFIPIYAKE-LGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGM--FALSQAQTP 295
Cdd:COG2211 240 FFLALALVAALLLYYFKYvLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLllLFFLGPGNL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447113088 296 FWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGS---ATATYFSFFD----SGIGFGSFILGIVAAKSSY 360
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrREGLYFGIFTfaikLGQALAGALAGLLLALFGY 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-174 |
6.21e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.43 E-value: 6.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFGAQ--SLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFI 168
Cdd:COG2271 262 LLLLALlpSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
....*.
gi 447113088 169 VCSVFS 174
Cdd:COG2271 342 LLAALA 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
46-377 |
7.24e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.44 E-value: 7.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 126 VAPaHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLVNIPHEAPVKKQKREKMKWKDL 205
Cdd:COG2807 134 WFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLW 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 206 IEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYG-ENVLVYPAIIIFT 283
Cdd:COG2807 213 RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLsAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 284 IGMFALSQAQTPFWFLSAgVLIGLGYGTLIPSFQTIAISAAPNHRR-GSATATYFSFFDSGIGFGSFILGIVAAKSSYHN 362
Cdd:COG2807 293 AGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSWT 371
|
330
....*....|....*
gi 447113088 363 MYFIAAIIVAFTLLL 377
Cdd:COG2807 372 AALLLLAALAVLMLV 386
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
46-378 |
1.84e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.98 E-value: 1.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRF-LHGIGFGMATTATGTIVT 124
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGlLGGGGAGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 125 DVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS-------FTVLFIVCSVFSLLAFLLGLLVNIPHEAPVKKQKR 197
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwrtallvLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 198 EKMKWKDLIEPSSIPI-ALTGFVLAFSYSGILSFIPIYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLV 275
Cdd:cd17355 199 PGSTLKEALRSASFWLlALAFFLCGFAVVGLIVHLVPYLADRGIsPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 276 YPAIIIFTIGMFALSQAQTPFWFLSA-GVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIV 354
Cdd:cd17355 279 AASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
330 340
....*....|....*....|....*..
gi 447113088 355 AAKSSYHNMYFIAAI---IVAFTLLLY 378
Cdd:cd17355 359 YDRTGSYTAAWALAValgLIAALLVLP 385
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
48-174 |
6.01e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 59.97 E-value: 6.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 48 GLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVA 127
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447113088 128 PAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS 174
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILA 127
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-164 |
1.37e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.61 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA 88
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 89 TVMYF--GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAH-------RRGEALAYFGVFMSLPMVIGPFLGLTIIS 159
Cdd:COG2211 308 LLLLFflGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
....*
gi 447113088 160 HFSFT 164
Cdd:COG2211 388 LFGYV 392
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
8-172 |
1.52e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.21 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 8 TKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 88 ATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSL-----PMVIGPFLGLTIISHFS 162
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLgqflsPLVLGPLVNLTGGLSGA 355
|
170
....*....|
gi 447113088 163 FTVLFIVCSV 172
Cdd:cd17473 356 FLILGVLALV 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
213-382 |
1.63e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 61.37 E-value: 1.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ 291
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALPSIAADLGAsSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 292 AQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:COG0477 99 APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG 178
|
170
....*....|.
gi 447113088 372 AFTLLLYYGLH 382
Cdd:COG0477 179 LLALVLRLRLP 189
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
46-376 |
2.93e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 61.18 E-value: 2.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:cd17333 32 DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 126 VAPaHRRGEALAYFGVFMSLPMVIGPFLGLTII-SHFSFTVLFIVCSVFSLLAFLLGLLVNIPHEAPVK-KQKREKMKWK 203
Cdd:cd17333 112 LFE-ESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARnPQQSVGAFSA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 204 DLIEPSSIPIALTGFVLAFSYSG----ILSFIPIYAKELGLAD--IASYFFIVYALVVVISRPFTGKIFDRYGENVLVYP 277
Cdd:cd17333 191 SASRLLRNPSIILGALALFLYVGaetaFSSWVPSYLVEKKHVSdgLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 278 AIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPnHRRGSATATYFSFFDSGIGFGSFILG-IVAA 356
Cdd:cd17333 271 SGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGfIAEA 349
|
330 340
....*....|....*....|
gi 447113088 357 KSSYHNMYFIAAIIVAFTLL 376
Cdd:cd17333 350 VGIQTAMLLITILYAIIFVL 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-372 |
3.23e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 3.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 34 VYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFG 113
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 114 MATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLlvnipheapvk 193
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 194 kqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLADI--ASYFFIVYALVVVISRPFTGKIFDRYGE 271
Cdd:cd17319 176 -----------FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLkqVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 272 NVLVYPAIIIF---TIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGS 348
Cdd:cd17319 245 GARRLVIIIGLllaAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAP 324
|
330 340
....*....|....*....|....
gi 447113088 349 FILGIVAAKSSYHNMYFIAAIIVA 372
Cdd:cd17319 325 LLIGYLVDATGSYTAAFLFLAAVA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-174 |
2.69e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 58.21 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLD-DLGRKKILFISLSLFLA 87
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 88 ATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFL-GLTIISHFSFTVL 166
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLaGFLLAATFGLTGA 362
|
....*...
gi 447113088 167 FIVCSVFS 174
Cdd:cd06174 363 FLVLAVLL 370
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
19-382 |
3.94e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 57.98 E-value: 3.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 19 LFLFLTFYMLMTTLPVYvidgLKGR---PEEIGLVATVFLISSVLCRPFTGKWLDDLG-RKKILFISLSLFLAATVMYFG 94
Cdd:cd17335 7 FFFFAALGSLLPFLSVY----LKQLglsPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 95 AQSLFLLLALRFlhgIGFGMATTATGTIVTDVAPAHRRGEALAYFGV--FMSLPMVIGPFLGLTIISHFS----FTVLFI 168
Cdd:cd17335 83 VAQIFWLLLLLV---ILGAFFSAPVVPLVDSITLQYLGEERERYGKQrlWGSIGFGIAALLVGILIDRSStyknYTIAFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 169 VCSVFSLLAFLLGLLVNIPheapvKKQKREKMKWKDLIE----PSSIPIALTGFVLAFSYSGILSFIPIYAKELGL-ADI 243
Cdd:cd17335 160 VFAVLMLLALLLALKFPFR-----PKHPEPNENTGGLLAllrnPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGsKTL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 244 ASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISA 323
Cdd:cd17335 235 IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 324 APNHRRGSATATYFS-FFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYGLH 382
Cdd:cd17335 315 APPGLRATAQGLLQGlYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-377 |
7.78e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.84 E-value: 7.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLP-VYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAAT 89
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPvLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 90 VMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT----V 165
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 166 LFIVCSVFSLLAFllgllvnipheapvkkqkrekmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIP-IYAKELGL-ADI 243
Cdd:cd17316 161 LFLIGALPALLAL--------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPtYLQTVLGLsPAT 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 244 ASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISA 323
Cdd:cd17316 215 SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLA 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447113088 324 A--PNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17316 295 ElfPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
6-161 |
8.44e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 8.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 6 LWTKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLF 85
Cdd:cd17321 165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447113088 86 LAATVMYFGAQSLFLLLALRFLH---GIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF 161
Cdd:cd17321 245 AVGLLLLALLGADSSVWLLLPGLvllGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
44-377 |
8.93e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.44 E-value: 8.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17365 33 PAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFllgllvnipheapvkkqkrekmkwk 203
Cdd:cd17365 113 SEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 204 dLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLA-DIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIF 282
Cdd:cd17365 168 -PLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSlSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 283 TIGMFALS-QAQTPFWFLSAGVLIGLGygtlIPSFQTIAISAAPNHRRGSATATYFSfFDSGIGFGSFILG------IVA 355
Cdd:cd17365 247 AVSLALLGvSPASLVLLYVLVFLAGAC----VNGAQVGLYALAARFYPTEVRATGVG-WALGVGRLGAILGpllgglLLA 321
|
330 340
....*....|....*....|..
gi 447113088 356 AKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17365 322 AGLGPESVFLALAIPAALGALA 343
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-173 |
1.03e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.47 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17329 202 FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVC 170
Cdd:cd17329 282 VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIL 361
|
...
gi 447113088 171 SVF 173
Cdd:cd17329 362 AAL 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-174 |
1.79e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.66 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 8 TKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 88 ATV-MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF-SFTV 165
Cdd:COG2223 284 GLLlLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTA 363
|
....*....
gi 447113088 166 LFIVCSVFS 174
Cdd:COG2223 364 AFLVFAVLA 372
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
70-379 |
2.64e-08 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 55.53 E-value: 2.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 70 DDLGRKKILFISLSLFLAATVM-----YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMS 144
Cdd:pfam05977 70 DNFDRRKIMLAGQLLLALVSTLltllaGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYN 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 145 LPMVIGPFLGLTIISHF--SFTVLFIVCSVFSLLAFLLGLlvniPHEAPVKKQKREKM------KWKdlIEPSSIPIA-- 214
Cdd:pfam05977 150 IARSVGPALGGVLLAAFgpAFTFALNALSYFAVIAALWRW----KRAAPASPLPRERIfgavraGLR--FTAMSRELRsv 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 215 -LTGFVLAFSYSGILSFIPIYAKELGLADIASYFFIVYALVV--VISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ 291
Cdd:pfam05977 224 lVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVgaILGALSLPRLRERLGSDRLVLLASVVTALVLLSLAL 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 292 AQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:pfam05977 304 APNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAAL 383
|
....*...
gi 447113088 372 AFTLLLYY 379
Cdd:pfam05977 384 LAGAAAGL 391
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
218-398 |
9.95e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.42 E-value: 9.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 218 FVLAFSYSGILSFIPIYAKELGLADI------ASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ 291
Cdd:cd17391 6 FFTGIGFSLIAPFLPLYIEQLGVTSGglvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 292 AQTPFWFLSAGVLIGLGYGTlIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:cd17391 86 VTNVWQLLILRLLQGVFSGY-VPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLL 164
|
170 180
....*....|....*....|....*..
gi 447113088 372 AFTLLLyyGLHGRKQKFKKQRTDGQIS 398
Cdd:cd17391 165 FLAFLL--TLFFVKEDFKPVEKKKMVS 189
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
249-377 |
2.01e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.58 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 249 IVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHR 328
Cdd:cd17503 38 TSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEK 117
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 447113088 329 RGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17503 118 RGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
231-378 |
2.37e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 52.18 E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 231 IPIYAKELGLADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYG 310
Cdd:cd17502 19 LPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGG 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447113088 311 TLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLY 378
Cdd:cd17502 99 GLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL 166
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
218-377 |
4.28e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 51.46 E-value: 4.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 218 FVLAFSYSGILSFIPIYAKELGLADIASY------FFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQ 291
Cdd:PRK09874 24 FLTGAAFSLVMPFLPLYVEQLGVTGHSALnmwsglVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 292 AQTPFWFLSAGVLIGLgYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIV 371
Cdd:PRK09874 104 AQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVL 182
|
....*.
gi 447113088 372 AFTLLL 377
Cdd:PRK09874 183 FLCFLV 188
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
227-377 |
9.06e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.43 E-value: 9.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 227 ILSFI-PIYAKELGLaDIASYFFIVYA--LVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGV 303
Cdd:TIGR00895 35 AMGFAaPAISAEWGL-DPVQLGFLFSAglIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRF 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447113088 304 LIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:TIGR00895 114 LAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLL 187
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
213-379 |
1.45e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 50.32 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIYAKELGLADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQA 292
Cdd:cd06179 3 LCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 293 QTPFWFLSAGVLIGLGYGTlIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKS--SYHNMYFIAAII 370
Cdd:cd06179 83 KSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIF 161
|
....*....
gi 447113088 371 VAFTLLLYY 379
Cdd:cd06179 162 NALALILLF 170
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-377 |
1.88e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.54 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFI-SLSLFLAATVMYFgAQSLFLLLALRFLHGIGFGMATTATGTIVT 124
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVgLLLMGAAALLMAL-VGSYPVLLVLLFLVGAGYGSVQPGGGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 125 DVAPAHRRGEALayfGVF-MSLPMviGPFLG----LTIISHFSFTVLFIVCSVFSLLAFLLGLLVNIPHEAPVKKQKREK 199
Cdd:cd17475 111 RWFPPRERGLAM---GIRqTGVPL--GGALAaallPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 200 MKWKDLIE----PSSIPIALTGFVLAFSYSGILSFIPIYAKE---LGLADIASYFFIVYALVVViSRPFTGKIFDRY--G 270
Cdd:cd17475 186 TLLRSLKEvlrnRDVWLIAIAGALLVAPQFALLTFLLLFLHDhlgLSVVAAGALLAVAQLGGAL-GRIGLGRVSDRVfgG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 271 ENVLVYPAIIIFTIGMFALSQ---AQTPFWFLsAGVLIGLGYGTL--IPSFQTIAISAAPNHRRGSATATYFSFFDSGIG 345
Cdd:cd17475 265 RRRPVLVITAAIAAAALLVLSllsPGTPLWLL-VLLLILLGLFAIgwNGLYLTLVAESAGPEQAGTALGLANTINFIGIA 343
|
330 340 350
....*....|....*....|....*....|...
gi 447113088 346 FGSFILG-IVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17475 344 IGPPLFGlLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
20-299 |
2.16e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 49.14 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 20 FLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISlslFLAATVMYFGAQSLF 99
Cdd:cd17331 10 VLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLS---FLSSALSYLLLAFAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 100 LLLALRFLHGIGFGMAT-TATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSF-------TVLFIVCS 171
Cdd:cd17331 87 SVPMLFLSRLPSVFMHAmQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEqaaalvaAVGSLLSI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 172 VFSLLAFLLGLLVNIPHEAPVKKQKREKMKWKDLIE----PSSIPIALTGFVLAFSYSGILSFIPIYAKE---LGLAD-- 242
Cdd:cd17331 167 VLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRllrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDffgLTPEEng 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113088 243 -IASYFFIVYALVVVISRPFTGKifdRYGENVLVYPAIIIFTIGMFALSQAQTPFWFL 299
Cdd:cd17331 247 yLMSYAGVLGMVVQGLLVGPLTK---RFGERSLLKLSVALLAIGYLLLAFVTTVWQLL 301
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
213-377 |
2.17e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.12 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAfsysgILSFI-PIYAKELGLADIASYFFIVYALV-VVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALS 290
Cdd:cd17365 8 IVLDGFDLA-----VMGFVaPALAQDWGLSPAQLGPVGSAALFgMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 291 QAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAII 370
Cdd:cd17365 83 FAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVP 162
|
....*..
gi 447113088 371 VAFTLLL 377
Cdd:cd17365 163 PLILLPL 169
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
44-357 |
3.10e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.89 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:TIGR00895 51 PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALV 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFS----------------------------- 174
Cdd:TIGR00895 131 SEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPlllllllmrflpesidflvskrpetvrri 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 175 LLAFLLGLLVNIPHEAPVKKQKRE------KMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELG--LADIASY 246
Cdd:TIGR00895 211 VNAIAPQMQAEAQSALPEQKSTQGtkrsvfKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGfsLSLAATG 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 247 FFIVYAlVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPN 326
Cdd:TIGR00895 291 GALFNF-GGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPT 369
|
330 340 350
....*....|....*....|....*....|..
gi 447113088 327 HRRGSATATYFsffdsGIG-FGSFILGIVAAK 357
Cdd:TIGR00895 370 AIRATGVGWAI-----GIGrLGAIIGPILAGY 396
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
8-162 |
3.63e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.73 E-value: 3.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 8 TKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447113088 88 ATVM---YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS 162
Cdd:cd17503 257 GTLLlafLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRT 334
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
11-375 |
6.03e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.07 E-value: 6.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDglkgrPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLD-----EAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT----VL 166
Cdd:cd17371 80 LCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiawrVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 167 FIVCSVFSLLAFLLGLLVNIPHEAPVKKQKREKMKWKDLI----EPSSIPIALTGFVLA----FSYSGILSFIPIYAK-E 237
Cdd:cd17371 160 FLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLrelfSPPLLRTTLLASLLAtgalGGYYGITTWLPSYLTgE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 238 LGLADIASYFFIVY-ALVVVISRPFTGKIFDRYGENvlvyPAIIIFTIGMFALSQAQTPF-----WFLSAGVLIGLGYGT 311
Cdd:cd17371 240 RGLSFEGSAGYLVVtILGGFLGYLAGGFLADRIGRR----NNFALFALGSAISILLYFFLplsptLILILGFPLGFFASG 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447113088 312 LIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHN-------MYFIAAIIVAFTL 375
Cdd:cd17371 316 PFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTaiavfaaVYYIAGLVLALLL 386
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
213-377 |
6.24e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.96 E-value: 6.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIYAKELGLADIASYF----FIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFA 288
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYvgllQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 289 LSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPnHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAA 368
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDE-EERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
....*....
gi 447113088 369 IIVAFTLLL 377
Cdd:cd17330 160 ALALLNLVL 168
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-355 |
6.82e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 47.76 E-value: 6.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:TIGR00881 31 DLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 126 VAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIIS-----HFSFTVLFIVCSVFSLLAFLLG----LLVNIP--------- 187
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAelyswHWVFIVPGIIAIIVSLICFLLLrdspQSCGLPpaeempnee 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 188 --HEAPVKKQKREKMK---WKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAK-ELGL-ADIASYFFIVYALVVVISRP 260
Cdd:TIGR00881 191 pdGDAEKKEEELTKKQiflQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTqEKGFsKEKASWAFTLYELGGLVGTL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 261 FTGKIFDRYGEN-----VLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIG-LGYGTlIPSFQTIAISAAPNHRRGSATA 334
Cdd:TIGR00881 271 LAGWLSDKLFNGrrgplAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGfLVYGP-QMLIGVIASELAPKKAAGTAAG 349
|
330 340
....*....|....*....|..
gi 447113088 335 tYFSFFDSGIG-FGSFILGIVA 355
Cdd:TIGR00881 350 -FVGFFAYLGGiLAGLPLGYLA 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
223-393 |
7.28e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 7.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 223 SYSGILS-FIPIYAKELGLAD-IASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLS 300
Cdd:cd17478 10 FYQGFLPaLLPLLIAKLGLSYaQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 301 AGVLIGLGYGTLIPSFQTIAISAAPNhRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYYG 380
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR 168
|
170
....*....|...
gi 447113088 381 LHGRKQKFKKQRT 393
Cdd:cd17478 169 LRPLKKPEAKKAA 181
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
46-377 |
9.39e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.22 E-value: 9.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAA-TVMYFGAQSLFLLLALRFLHGIGFGMA-TTATGTIV 123
Cdd:cd17353 39 SVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGfILSAFAISLPLLFLGYGVLGGIGAGIGyITPVSTAV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TdVAPAHR----------RGEALAYFGVFMSLPM----VIGPFLGLTIIshfsFTVLFIVCSVFSLLAFLLGLLVNIPHE 189
Cdd:cd17353 119 K-WFPDKRglatgiviagFGLGSLIFSPLIAYLIntvgVPTTFLILGII----FLIIIVIGAFLIRDPPKGWVPPGVDPL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 190 APVKKQKREKMKWKDLIE-PSSIPIALTGFVLAFSYSGILSFIPIYAKELGLAD--IASYFFIVYALVVVISRPFTGKIF 266
Cdd:cd17353 194 ANNAENSPRDYTPREMLRtPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDagIAALAVSILSIFNGGGRPFWGWLS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 267 DRYGENVLVYPAIIIFTIGMFALSQAQ-TPFWFLSAGVLIGLGYGTLIPSFqtIAISAapnHRRGSAT-ATYFSFFDSGI 344
Cdd:cd17353 274 DKIGRKNTLSIAFLIQGVAMFLLPFIGsVAVLFVLGVALIGFCYGGGFALF--PALTA---DFFGTKNaGTNYGLLYTAK 348
|
330 340 350
....*....|....*....|....*....|....*..
gi 447113088 345 GFGSFILGIVAAK----SSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17353 349 GVGGLIGPIIAAYvlytGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
213-381 |
1.21e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 213 IALTGFVLAFSYSGILSFIPIYAKELGLADIASYFFIVYAlVVVISRPFTGKIF----DRYGENVLVYPAIIIFTIGMFA 288
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFA-AGFLGRPIGALLFgylgDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 289 LSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHN----MY 364
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwriLF 162
|
170
....*....|....*..
gi 447113088 365 FIAAIIVAFTLLLYYGL 381
Cdd:cd17316 163 LIGALPALLALLLRRRT 179
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
12-174 |
2.22e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.03 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 12 LGTCFSSLFLFLTFYMLMTTLPVYVID----GLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLA 87
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 88 ATVMY-FGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS---- 162
Cdd:cd17504 260 GLLLLaLLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTvsit 339
|
170 180
....*....|....*....|.
gi 447113088 163 ---------FTVLFIVCSVFS 174
Cdd:cd17504 340 sggvptegaYVLAFLIGAALA 360
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
18-379 |
3.37e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.45 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 18 SLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQS 97
Cdd:TIGR00710 14 SILGPLGIDMYLPAFPEIAAD-LSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 98 LFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLA 177
Cdd:TIGR00710 93 IETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 178 FLLGLLVnIPHEAPVKKQKREKMKWKDLIEP-SSIPIALTGFVLAFSYSGILSFIP----IYAKELGLA-DIASYFFIVY 251
Cdd:TIGR00710 173 SALIFFI-LPETLPYEARIQISTYFETFLLLlKSKMFWGYALIYGASFGGFFAFFSgapfVYIDIMGVSpSVFGLLFALN 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 252 ALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQ---TPFWFLSAGV--LIGLGYGTLIPSFQTIAISAAPn 326
Cdd:TIGR00710 252 IIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAilgLGSWAMIIGPmmFVGIGNSMISSIAMAYALEDFP- 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 447113088 327 HRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:TIGR00710 331 HVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYY 383
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
231-377 |
3.47e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 45.83 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 231 IPIYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGY 309
Cdd:TIGR00711 25 IPTIAGDLGSsLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGG 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447113088 310 GTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:TIGR00711 105 GPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVV 172
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
48-154 |
3.65e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 45.34 E-value: 3.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 48 GLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATgTIVTDVA 127
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVT 145
|
90 100
....*....|....*....|....*..
gi 447113088 128 PAHRRGEALAYFGVFMSLPMVIGPFLG 154
Cdd:cd17389 146 SPKKRSKGMALIGVAFSLGFIIGPMIG 172
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
245-377 |
5.58e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 42.64 E-value: 5.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 245 SYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAA 324
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 447113088 325 PNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
47-375 |
7.96e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 44.37 E-value: 7.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 47 IGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATV--MYFGAQSLFLLLALRFLHG-IGFGMATTATGTIV 123
Cdd:COG2270 54 WGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATaaLFFVAPGGLWLGLLLFVLAnIGFEGSLVFYNAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TDVAPAHRRGE------ALAYFG----VFMSLPMVIGP-FLGLT---IISHFSFTVLFIVCSVFSLLAFLLGLLVNIPHE 189
Cdd:COG2270 134 PDIATPEEIGRvsglgwALGYLGgvllLLINLALFLKPeAFGLPdagEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 190 APVKKQKREKMK--WKDLIEPSSIPIALTgFVLAF-----SYSGILSFIPIYA-KELGLADIA-SYFFIVYALVVVISRP 260
Cdd:COG2270 214 APPRGAVRAGFRelRRTLRELRRYRDLLR-FLLAYffyrdGVQTVIAFAGIYAaGVLGFSTTElIVFGLLVQIVAALGAL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 261 FTGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSatatYFSFF 340
Cdd:COG2270 293 LFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAE----FFGLY 368
|
330 340 350
....*....|....*....|....*....|....*....
gi 447113088 341 D----SGIGFGSFILGIVAAKSSYHNmYFIAAIIVAFTL 375
Cdd:COG2270 369 AlsgkAASFLGPLLFGLVTQLTGSQR-LGILSLIVFFVI 406
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
28-330 |
1.32e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 28 LMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLF-LAATVMYFgAQSLFLLLALRF 106
Cdd:cd17388 21 VLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAaLDYLLMAF-APTLWWLYLGRI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 107 LHGIGFGMATTATGTIVtDVAPAHRRGEALAYFGVFMSLPMVIGPFLGlTIISHFSFTVLFIVCSVFSLLAFLLGLLVni 186
Cdd:cd17388 100 IAGITGATGAVAAAYIA-DVTPPEQRARNFGLLGAAFGLGFIAGPALG-GLLGEISPRAPFLVAAGLNGLNFLLGLFV-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 187 pHEAPVKKQKREKMKWKDLiepssipIALTGFVLAFSYSGIL----SFIPIYAKELGLADIASYF--------------- 247
Cdd:cd17388 176 -LPESLPPERRRAFRWRRA-------NPFGSLRWLTGFPGLLgllaVFFLIQLIGQVPATTWVLFtedrfdwsptmvgls 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 248 FIVYALVVVISRPF-TGKIFDRYGENVLVYPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGyGTLIPSFQTIAISAAPN 326
Cdd:cd17388 248 LAVFGLLHALFQAFvTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALG-GIAGPALQGLLSRQVPE 326
|
....
gi 447113088 327 HRRG 330
Cdd:cd17388 327 NEQG 330
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
46-377 |
2.07e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.02 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:cd17393 35 ALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 126 VAPAHRRgEALAYFGVFMSLPMVIGPFLGLTIIS-------HFS-FTVLFIVCSVFSLLAFLLGLLVNIPHEAPVKKQKR 197
Cdd:cd17393 115 VERAYGR-PIMSSLHAMWSLGGLAGALLGAAAIGagvspgvHLLaAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 198 EKmkwkdLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLAD--IASYFFIVYALVVVISRPFTGKIFDRYGENVLV 275
Cdd:cd17393 194 FL-----LPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASaaLAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 276 YPAIIIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPsfqtIAISAA---PNHRRGSATATYFSFFDSGIGFGSFILG 352
Cdd:cd17393 269 RAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVP----LAFSAAgalPGLAAGIAVARVATLGYLGFLVGPPLIG 344
|
330 340
....*....|....*....|....*
gi 447113088 353 IVAAKSSYHNMYFIAAIIVAFTLLL 377
Cdd:cd17393 345 FLADATGLRTAFLVVALLALLVALL 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
9-173 |
3.14e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.56 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 9 KDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDL---GRKKILFISLSLF 85
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 86 LAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFL-GLTIISHFSFT 164
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDATGSYT 338
|
....*....
gi 447113088 165 VLFIVCSVF 173
Cdd:cd17319 339 AAFLFLAAV 347
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
39-174 |
3.79e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.18 E-value: 3.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 39 GLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTA 118
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 447113088 119 TGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFS--FTVLFIVCSVFS 174
Cdd:cd17315 108 VPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPA 165
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
44-323 |
4.09e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 42.21 E-value: 4.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGrKKILFISLSLFLAATVMYFG----AQSLFLLLALR----FLHGIGFGMA 115
Cdd:cd17385 33 DTIIGLVFGCFALVIFLTSPIFGKYLVKIG-AKFMFVAGMFVSGGCTILFGfldrVPDGTVFIALCflvrIVEAVGFAAF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 116 TTATGTIVTDVAPAHRrGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIV--CSVFSLLAFLLGLlvnIPHEAPVK 193
Cdd:cd17385 112 ITASFAIIAKEFPNNI-ATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVlgCLLLLTVPLNMFI---LPRYDDDP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 194 KQKREKMkWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRY--G 270
Cdd:cd17385 188 SPKSGSM-LKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLsPGQVGLMFLILAGSYAISAPLWGWLSDKKkiP 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 447113088 271 ENVLVYPAIII----FTIGMFALSQAQTPFWFLSAG-VLIGLGYG-TLIPSFQTIAISA 323
Cdd:cd17385 267 KWLMVIGSIITgvgfLLLGPAPLLPIKSELWMVIIGlVLLGLSLGaALVPTFPELLNCA 325
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
15-172 |
5.12e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.82 E-value: 5.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 15 CFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDL-GRKKILFISLSLFLAATVMYF 93
Cdd:cd17331 213 LLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRfGERSLLKLSVALLAIGYLLLA 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447113088 94 GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSV 172
Cdd:cd17331 293 FVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAA 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
6-173 |
5.69e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 5.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 6 LWTKDFLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDD-LGRKKILFISLSL 84
Cdd:cd17330 171 FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERKLLRLGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 85 FLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSFT 164
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG 330
|
....*....
gi 447113088 165 VLFIVCSVF 173
Cdd:cd17330 331 VPFLLAAGL 339
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
247-379 |
6.56e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.41 E-value: 6.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 247 FFIVYALVVVISRPFTGKIFDRYGENVLVYPAI-------------------IIFTIGMFALSQAQTPFWFLSAG-VLIG 306
Cdd:cd17346 27 LYLTAQLGDGFSEADAASIYGAYTALVYLTPIIggwladkvlgarrtvfiggILMALGYLLLALSPFSVSMLYLGlALII 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447113088 307 LGYGTLIPSFQTI--AISAAPNHRRGSAtatyFSFFDSGIGFGSF----ILGIVAAKSSYHNMYFIAAIIVAFTLLLYY 379
Cdd:cd17346 107 VGNGLFKPNISSLvgKLYDENDPRRDSG----FSIFYMGINLGAFlaplLCGTLGDNYGYHYGFGLAAVGMLLGLLIFL 181
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
15-174 |
7.37e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.46 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 15 CFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIG-----LVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAAT 89
Cdd:cd17313 246 WWIAFFPFELFFTDYMGEEVYHGTSAASSHYGAGvrmgaWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGM 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 90 VMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRR--GEALAYFGVFMSLPMVIGPFLGLTIISHFSFTVLF 167
Cdd:cd17313 326 ALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVF 405
|
....*..
gi 447113088 168 IVCSVFS 174
Cdd:cd17313 406 PVAAVAS 412
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
221-382 |
1.15e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.68 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 221 AFSYSGILSFIPIYAKELGLADIASYFFI-VYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALSQAqTPFWFL 299
Cdd:cd17475 9 SLVAQGIPALAPFLQEDLHLSLAQVGLLLsALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV-GSYPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 300 SAG-VLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAFTLLLY 378
Cdd:cd17475 88 LVLlFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLF 167
|
....
gi 447113088 379 YGLH 382
Cdd:cd17475 168 WLFY 171
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
11-173 |
1.47e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGkWLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17352 185 FVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLG-LLADKPRIGRLYLYIFTLLILGL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 91 MYFG---AQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIG-PFLGLTIISHFSFTVL 166
Cdd:cd17352 263 SLLAfplATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGpPIAGLLRDYTGDYDAA 342
|
....*..
gi 447113088 167 FIVCSVF 173
Cdd:cd17352 343 FYFCGAC 349
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
44-290 |
1.53e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 40.64 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17358 40 VAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TDVAPAHRRGEalayFGVFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLV------------------- 184
Cdd:cd17358 120 AEIAPKNVRGA----LGSLNQLLVNIGILLGYVLGSFLPWRTLALIGAIPPVVFLILLFFIpesprwlakkgreeeaeks 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 185 ---------NIPHEAPVKKQKREKMK-------WKDLIEPSSIPIALTGFVLAFSY--SGILSFIpIYA----KELGLAD 242
Cdd:cd17358 196 lqflrgkdaDISKEAAEIQEELAELEkeakessFSDLFQRKYLKPLVIGLGLMLFQqlSGINAVI-FYAssifDEAGSGL 274
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 447113088 243 IASYFFIVYALVVVISRPFTGKIFDRYGENVLVYPAIIIFTIGMFALS 290
Cdd:cd17358 275 DPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALG 322
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
22-173 |
1.65e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.29 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 22 FLTFYMLMTTLPVYvIDGLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLL 101
Cdd:cd17390 9 LFGVSMILPLLSTH-IRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALL 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447113088 102 LALRFLHGIgFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLG--LTIISHFSFTVLFIVCSVF 173
Cdd:cd17390 88 FLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGghLAETDGGFYYVALLCSAIF 160
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-373 |
1.76e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.09 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 16 FSSLFLFLtFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSV---LCRPFTGKWLDDLGRKKILFISLSLFLAA-TVM 91
Cdd:cd17314 7 VSFLLSAM-STGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLgmlLTQPILGFIADSFGPRPLMALAGIMVLAGyTYL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 92 YFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPaHRRGEALAYFGVFMSLPMVIGPFLGLTIISHFSF--TVLFIV 169
Cdd:cd17314 86 SYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLalVYTILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 170 CSVFSLLAFLLGLLVNIPHEAPVKKQKREKmKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELG--LADIASYF 247
Cdd:cd17314 165 ILAAIVLSVVSLLGFKEPPDNQARLHVQKK-KTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVrsLQLDAPSF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 248 FI----VYALVVVISRPFTGKIFDRYGENVLVYPAIIIF---TIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFQTIA 320
Cdd:cd17314 244 VTklmsIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTIlglGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATV 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 447113088 321 ISAAPNHRRGSATATYFSFFDSGIGFGSFILGIVAAKSSYHNMYFIAAIIVAF 373
Cdd:cd17314 324 STVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVF 376
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
63-168 |
2.72e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 39.62 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 63 PFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVAPAHRRGEALAYF-GV 141
Cdd:PRK10473 56 LFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLnGI 135
|
90 100
....*....|....*....|....*..
gi 447113088 142 FMSLPmVIGPFLGLTIISHFSFTVLFI 168
Cdd:PRK10473 136 TCIIP-VLAPVLGHLIMLKFPWQSLFY 161
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
46-154 |
2.81e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 39.64 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 46 EIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTD 125
Cdd:cd17362 40 QSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAE 119
|
90 100
....*....|....*....|....*....
gi 447113088 126 VAPAHRRGEALAYFGVFMSLPMVIGPFLG 154
Cdd:cd17362 120 TSPSHIRGLLVSLKELFIVLGILLGYVSG 148
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
11-127 |
3.36e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.51 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 11 FLGTCFSSLFLFLTFYMLMTTLPVYVIDGLKGRPEEIGLVATVFLISSVLCRPFTGKwLDDLGRKKILFISLSLFLAATV 90
Cdd:cd17332 223 FLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPL-KKRFGKKKAFFIGLLLAILGLL 301
|
90 100 110
....*....|....*....|....*....|....*....
gi 447113088 91 MYF--GAQSLFLLLALRFLHGIGFGMATTATGTIVTDVA 127
Cdd:cd17332 302 LLFflPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVI 340
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
44-354 |
3.68e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 39.15 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILfISLSLFLAAtVMYFGAQSLFLLLALRFLHGI-GFGMATTATGTI 122
Cdd:pfam12832 33 PSEIGLITAILPLTRILAPPIWGWLADRTGKRKAV-VRLASILAA-VLFLSVLFIPISLTFWWLALLvVLFSFFWNAILP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 123 VTDVAPAHRRGEALAYFG---VFMSLPMVIGPFLGLTIISHFSFTVLFIVCSVFSLLAFLLGLLV--NIPHEAPVKKQKR 197
Cdd:pfam12832 111 QFEVATLQHLGEKRKDYGrqrLWGSVGFALSVFGLGALFDHYSVGLLPSVLFYLFAALMLLSLLLplAPPEMEYESKGGS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 198 EKMKWKDLIEPSSIPIALTGFVLAFSYSGILSFIPIYAKELGLAD-IASYFFIVYALVVVISRPFTGKIFDRYGENVLVY 276
Cdd:pfam12832 191 KAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNtLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 277 PAIIIFTIGMFALSQ-AQTPFWFLSAGVLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSF-FDSGIGFGSFILGIV 354
Cdd:pfam12832 271 IALLLTALRWLLYAFfVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLyFGLGGALGSLIGGQL 350
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
48-133 |
4.62e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.70 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 48 GLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIVTDVA 127
Cdd:cd17359 39 GLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVA 118
|
....*.
gi 447113088 128 PAHRRG 133
Cdd:cd17359 119 PAEIRG 124
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
228-350 |
6.33e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.25 E-value: 6.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 228 LSFIPIYAKELGL-ADIASYFFIVYALVVVISRPFTGKIFDRYG-ENVLVYPAII--IFTIGM--FALSQAQTPFWFLSA 301
Cdd:cd17337 17 QGFLSPYLVDLGFsEAQAALLFTVYGLTVAIASWLSGVLAELFGpRRVMLIGLIIwlVFEVLFlaFGLPSHNYPLMLLTY 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 447113088 302 GvLIGLGYGTLIPSFQTIAISAAPNHRRGSATATYFSFFDSGIG-FGSFI 350
Cdd:cd17337 97 G-LRGFGYPLFAYSFLVWITYRTPAERLGSAVGWFWFAFTGGLPvLGSYL 145
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
44-358 |
6.39e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.37 E-value: 6.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 44 PEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLLALRFLHGIGFGMATTATGTIV 123
Cdd:cd17328 33 DSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTII 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 124 TDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLTIISHF-SFTVLFIVCSVFSLLAFL-LGLLVNIPHEAPVKKQKREKMK 201
Cdd:cd17328 113 ADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAIlLLLFVREPPRGAAEGGVMAKST 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 202 WKDLIE--------PSSIPIALTGFVLAFSYSGILSFIPIY------AKELGLADIASYFFIVYA---LVVVISRPFTGK 264
Cdd:cd17328 193 ATSFLAdlkalaknPSFILSTLGFTAVSFVTGALAFWAPTFflrafgVGDLSSADVGLIFGAITCiagVLGVLLGGILAD 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 265 IFDRYGENVLVY-PAI-----IIFTIGMFALSQAQTPFWFLSAGVLIGLGYGTLIPSFqTIAISAAPNHRRGSATAtYFS 338
Cdd:cd17328 273 RLRRKTPRADPLvCAVgllaaAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVF-AILLYVVIPTRRSTASA-IQI 350
|
330 340
....*....|....*....|.
gi 447113088 339 FFDSGIG-FGSFILGIVAAKS 358
Cdd:cd17328 351 LLSHLLGdAGSPYLIGLISDL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-173 |
7.03e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 7.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113088 23 LTFYMLMTTLPVYVIDgLKGRPEEIGLVATVFLISSVLCRPFTGKWLDDLGRKKILFISLSLFLAATVMYFGAQSLFLLL 102
Cdd:cd17478 209 WVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYI 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447113088 103 ALRFLhGIGFGMATTATGTIVTDVAPAHRRGEALAYFGVFMSLPMVIGPFLGLtIISHFSFTVLFIVCSVF 173
Cdd:cd17478 288 LLVLA-GFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGA-LADAFGLESVLLILALL 356
|
|
| |
