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Conserved domains on  [gi|447113812|ref|WP_001191068|]
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MULTISPECIES: acid resistance transcriptional activator GadX [Enterobacteriaceae]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 11484544)

AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 1-274 0e+00

DNA-binding transcriptional regulator GadX; Provisional


:

Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 527.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812   1 MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKIS 80
Cdd:PRK09978   1 MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  81 SLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWT 160
Cdd:PRK09978  81 SLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240
Cdd:PRK09978 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 447113812 241 ERSAQGLPNRDSAASIVAQGNFYGTDRSAEGIRL 274
Cdd:PRK09978 241 ERSAQGLPNRDSAASIVAQGNFYGTDRSAEGIRL 274
 
Name Accession Description Interval E-value
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 1-274 0e+00

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 527.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812   1 MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKIS 80
Cdd:PRK09978   1 MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  81 SLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWT 160
Cdd:PRK09978  81 SLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240
Cdd:PRK09978 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 447113812 241 ERSAQGLPNRDSAASIVAQGNFYGTDRSAEGIRL 274
Cdd:PRK09978 241 ERSAQGLPNRDSAASIVAQGNFYGTDRSAEGIRL 274
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
158-239 3.96e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 100.32  E-value: 3.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812   158 EWTLARIASELLMSPSLLKKKLREEE-TSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTP 236
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETgTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 447113812   237 TEY 239
Cdd:smart00342  81 SEY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
160-245 1.96e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.44  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 160 TLARIASELLMSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTE 238
Cdd:COG2207  170 TLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249


                 ....*..
gi 447113812 239 YQERSAQ 245
Cdd:COG2207  250 YRKRLRA 256
HTH_18 pfam12833
Helix-turn-helix domain;
164-242 1.14e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 73.01  E-value: 1.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  164 IASELLMSPSLLKKKLREEE-TSYSQLLTECRMQRALQ-LIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQE 241
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELgLSPKEYLRRLRLERARRlLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 447113812  242 R 242
Cdd:pfam12833  81 R 81
 
Name Accession Description Interval E-value
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 1-274 0e+00

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 527.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812   1 MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKIS 80
Cdd:PRK09978   1 MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVLVSRDTLSLFLPMLKEEALNLHAHKKVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  81 SLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWT 160
Cdd:PRK09978  81 SLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240
Cdd:PRK09978 161 LARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 447113812 241 ERSAQGLPNRDSAASIVAQGNFYGTDRSAEGIRL 274
Cdd:PRK09978 241 ERSAQGLPNRDSAASIVAQGNFYGTDRSAEGIRL 274
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
158-239 3.96e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 100.32  E-value: 3.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812   158 EWTLARIASELLMSPSLLKKKLREEE-TSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTP 236
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETgTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 447113812   237 TEY 239
Cdd:smart00342  81 SEY 83
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 117-256 3.22e-25

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 100.54  E-value: 3.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 117 LIFALLSVFLEDEHFIPLLLN-VLQPNMRTRvcTVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRM 195
Cdd:PRK09940 110 LLFSCLSIFAACKGFITLLTNgVLSVSGKVR--NIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARM 187

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447113812 196 QRALQLIVIHGfSIKRVAVSCGYHSVSYFIYVFRNYYGMTP----TEYQERSAQGLPNRDSAASI 256
Cdd:PRK09940 188 QHAKNLIRVEG-SVNKIAEQCGYASTSYFIYAFRKHFGNSPkrvsKEYRCQRHTGMNTGNTMSAL 251
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 102-239 5.20e-24

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 98.53  E-value: 5.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 102 QNKNLRYAEMLRKRALIFaLLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLRE 181
Cdd:PRK15185 167 NNKSCIENEELIPYFLLF-LLTAFLRLPESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAE 245

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447113812 182 EETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEY 239
Cdd:PRK15185 246 EGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 9-239 1.29e-23

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 97.06  E-value: 1.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812   9 LIAYARHKYILTMVNGEYRYFNGGDLVFADASQ---IRVDKCVE--NFVLVSRDTLSLflpmlkEEALN--LHAHKKISS 81
Cdd:PRK15186  41 LIKLTTGKISITTSSGEYITASGPMLIFLAKDQtihITMEETHEqlNYNLIELDSASI------KNAYNffLYEHADFSA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  82 LLVHHCSRDI--PVFQEVAQL-----SQNKNLRYAEMlRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNN 154
Cdd:PRK15186 115 PLTKPTTKHLlaPIETGVARVfnllhSSNKSQKLSQD-KKEYLIRFLLSEFIYEPEAFALFRELSQNTLAENIYNIIISD 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 155 IAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGM 234
Cdd:PRK15186 194 ISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKT 273


                 ....*
gi 447113812 235 TPTEY 239
Cdd:PRK15186 274 TPSEF 278
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
160-245 1.96e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.44  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 160 TLARIASELLMSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTE 238
Cdd:COG2207  170 TLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249


                 ....*..
gi 447113812 239 YQERSAQ 245
Cdd:COG2207  250 YRKRLRA 256
HTH_18 pfam12833
Helix-turn-helix domain;
164-242 1.14e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 73.01  E-value: 1.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  164 IASELLMSPSLLKKKLREEE-TSYSQLLTECRMQRALQ-LIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQE 241
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELgLSPKEYLRRLRLERARRlLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 447113812  242 R 242
Cdd:pfam12833  81 R 81
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 121-239 2.16e-16

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 77.38  E-value: 2.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 121 LLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQ 200
Cdd:PRK15044 171 LISAFVRKPGGFDFLERAIKITTKEKVYNIIISDLTRKWSQAEVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIK 250

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 447113812 201 LIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEY 239
Cdd:PRK15044 251 LLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITPLSF 289
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 145-244 1.03e-13

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 70.08  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 145 TRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIViHGFSIKRVAVSCGYHSVSY 223
Cdd:COG2169   87 ARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAAGFGSLSR 165

                         90       100
                 ....*....|....*....|.
gi 447113812 224 FIYVFRNYYGMTPTEYQERSA 244
Cdd:COG2169  166 FYEAFKKLLGMTPSAYRRGGA 186
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
94-244 2.99e-12

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 65.38  E-value: 2.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  94 FQEVAQLSQNKNlRYAEMLRKRALIFALLSVFLEDEhfiplllNVLQPNMRTRV---CTVINNNIAHEWTLARIASELLM 170
Cdd:PRK10572 140 FGQIEQAGQSEG-RYSELLAMNLLERLLLRCMEAIP-------ESLHPPMDPRVreaCQYISDHLASEFDIESVAQHVCL 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447113812 171 SPSLLKKKLREE-ETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSA 244
Cdd:PRK10572 212 SPSRLAHLFRQQlGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARCE 286
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 146-242 1.97e-11

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 63.25  E-value: 1.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 146 RVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEeTSYS--QLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSY 223
Cdd:COG4977  214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAA-TGTTpaRYLQRLRLERARRLLETTDLSIEEIAAACGFGSASH 292

                         90
                 ....*....|....*....
gi 447113812 224 FIYVFRNYYGMTPTEYQER 242
Cdd:COG4977  293 FRRAFRRRFGVSPSAYRRR 311
ftrA PRK09393
transcriptional activator FtrA; Provisional
 151-244 2.09e-09

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 57.28  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 151 INNNIAHEWTLARIASELLMSPSLLKKKLREE--ETSYSQLLTEcRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVF 228
Cdd:PRK09393 227 MRAHLAEPHTVASLAARAAMSPRTFLRRFEAAtgMTPAEWLLRE-RLARARDLLESSALSIDQIAERAGFGSEESLRHHF 305

                         90
                 ....*....|....*.
gi 447113812 229 RNYYGMTPTEYQERSA 244
Cdd:PRK09393 306 RRRAATSPAAYRKRFG 321
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 205-239 2.32e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 46.38  E-value: 2.32e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 447113812  205 HGFSIKRVAVSCGYhSVSYFIYVFRNYYGMTPTEY 239
Cdd:pfam00165   7 TNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQY 40
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
95-245 2.26e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 47.74  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  95 QEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVL-QPNMRTRVCTVINNNIAHEWTLARIASELLMSPS 173
Cdd:PRK13502 128 QVINQLEHESNGRDPLANEMAELLFGQLVMTLKRHRYATDDLPATsRETLLDKLITALANSLECPFALDAFCQQEQCSER 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447113812 174 LLKKKLREEE-TSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQ 245
Cdd:PRK13502 208 VLRQQFRAQTgMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRHLSNQ 280
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
64-245 4.17e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 41.24  E-value: 4.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812  64 PMLKEEALNLHAHKKISSLLVHHCSRDIPVFQEVAQLsqnknlryaemlrkralIFALLSVFLEDEHFI-----PLLLNV 138
Cdd:PRK13500 144 PHWRLGSVGMAQARQVIGQLEHESSQHVPFANEMAEL-----------------LFGQLVMLLNRHRYTsdslpPTSSET 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 139 LQPNMRTRVCTVINNNIAhewtLARIASELLMSPSLLKKKLREEE-TSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCG 217
Cdd:PRK13500 207 LLDKLITRLAASLKSPFA----LDKFCDEASCSERVLRQQFRQQTgMTINQYLRQVRVCHAQYLLQHSRLLISDISTECG 282

                        170       180
                 ....*....|....*....|....*...
gi 447113812 218 YHSVSYFIYVFRNYYGMTPTEYQERSAQ 245
Cdd:PRK13500 283 FEDSNYFSVVFTRETGMTPSQWRHLNSQ 310
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 151-191 7.08e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 36.36  E-value: 7.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 447113812  151 INNNIAHEWTLARIASELLMSPSLLKKKLREE-ETSYSQLLT 191
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYtGVTPSQYRH 42
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
151-245 1.84e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 39.12  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447113812 151 INNNIAHEWTLARIASELLMSPSLLKKKLREEE-TSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFR 229
Cdd:PRK13501 185 LQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTgMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFT 264

                         90
                 ....*....|....*.
gi 447113812 230 NYYGMTPTEYQERSAQ 245
Cdd:PRK13501 265 REAGMTPRDYRQRFIR 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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