|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
10-884 |
0e+00 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 565.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 10 EALLNHVNRYQAGRLTVFLGAAPGVGKTYAMLARAKELFQQGTDVVVGIVETHGRIETLKILEGLPQIARKEMQYQGHIL 89
Cdd:PRK10490 11 DRLLEQTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPPKRIHHRGRHI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 90 EEMDLDAILLRHPQIVLVDELAHRNVPNSRHERRWQDVNELLDAGIDVFTAINIQHLESLNDVVYQITGIRVNETVPDRV 169
Cdd:PRK10490 91 SEFDLDAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGIQVRETVPDPF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 170 FDRIRDIRLIDLPVSELIERLHQGKVYVPEQANLALQGFFSISNLTALRELAMQCVAEHVDSDLKESYASKGLKSI-SLQ 248
Cdd:PRK10490 171 FDAADEVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDHQGEEKVwHTR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 249 NELMIAIdGQGS-SEYLVRAGCRLAERYGATWTVVNVAK----SLDFGQSSGnsykkeyieIDRAFELARQLGGRTEILY 323
Cdd:PRK10490 251 DAILLCI-GHNTgSEKLVRTAARLAARLGSVWHAVYVETprlhRLPEKKRRA---------ILSALRLAQELGAETATLS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 324 GHRVASVLMDAAVDRGISNLVIGK-SISPWWLKL-FKKNLAQQ---------LLNQENSIALTILHPEQGTKKINQLEKP 392
Cdd:PRK10490 321 DPAEEKAVLRYAREHNLGKIIIGRrASRRWWRREsFADRLARLgpdldlvivALDEPPARAIAKAPDSRPFKEKWRVQIQ 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 393 SFLslkesvfVLAVTCASI-FIAHFAEVLFGIEDFSVIFIISVLIVATKTRMLAAVVAALICFLAYNFFFIAPRYTFQIS 471
Cdd:PRK10490 401 GCL-------VAIALCALItLIAMQWLPAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVS 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 472 AHQGVVTVVAFFAAALIAGRLASQLRQQVLSLKAANAYTTVMQDLARKLSSAVNLEEVMQTGRMTLETQLQTKVWISIRD 551
Cdd:PRK10490 474 DVQYLLTFAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLLPD 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 552 -----KIISSDIELNDKEKVAAEWCLKHQQPCGRFTDTLSQSNWWFLPLLEQKNSLGIVGIyfkdEVVSLNF----EQKK 622
Cdd:PRK10490 554 dngklQPLTHDQGMTPWDDAIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAV----EPGNLRQlmipEQQR 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 623 LTESVIEYIAQAALRTQLVNELEQAKVTSETERLRSALLSSVSHDLRSPLASIIGAADTLA-NFKAE------MTEQDQQ 695
Cdd:PRK10490 630 LLETFTLLIANALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTlDLASEgspharQASEIRQ 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 696 DLLETIhlegerldRYIQNLLDMTRLGHEGLTLKRDWIGVDELIGSATRRLKRYKPDTQVVVQLPEQSISLYVHPALVEQ 775
Cdd:PRK10490 710 QVLNTT--------RLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFER 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 776 AIFNVLENAANFSPPDESVMIRAQLsSEDEVKIEIEDKGAGIPEDERHRIFDMFytiERGDRGKF--GTGLGLTIVKAII 853
Cdd:PRK10490 782 VLINLLENAVKYAGAQAEIGIDAHV-EGERLQLDVWDNGPGIPPGQEQLIFDKF---ARGNKESAipGVGLGLAICRAIV 857
|
890 900 910
....*....|....*....|....*....|.
gi 447114342 854 GAHMGTIEAfSGRQNKGTLIQIKLPIHPVKE 884
Cdd:PRK10490 858 EVHGGTIWA-ENRPEGGACFRVTLPLETPPE 887
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
22-229 |
8.80e-128 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 382.53 E-value: 8.80e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 22 GRLTVFLGAAPGVGKTYAMLARAKELFQQGTDVVVGIVETHGRIETLKILEGLPQIARKEMQYQGHILEEMDLDAILLRH 101
Cdd:pfam02702 3 GRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILARR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 102 PQIVLVDELAHRNVPNSRHERRWQDVNELLDAGIDVFTAINIQHLESLNDVVYQITGIRVNETVPDRVFDRIRDIRLIDL 181
Cdd:pfam02702 83 PEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELVDL 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 447114342 182 PVSELIERLHQGKVYVPEQANLALQGFFSISNLTALRELAMQCVAEHV 229
Cdd:pfam02702 163 TPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
639-881 |
5.31e-70 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 231.33 E-value: 5.31e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 639 QLVNELEQAKvtsETERLRSALLSSVSHDLRSPLASIIGAADTLANfKAEMTEQDQQDLLETIHLEGERLDRYIQNLLDM 718
Cdd:COG2205 1 ELEEALEELE---ELERLKSEFLANVSHELRTPLTSILGAAELLLD-EEDLSPEERRELLEIIRESAERLLRLIEDLLDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 719 TRLGHEGLTLKRDWIGVDELIGSATRRLKRY--KPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMI 796
Cdd:COG2205 77 SRLESGKLSLELEPVDLAELLEEAVEELRPLaeEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 797 RAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKfGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIK 876
Cdd:COG2205 157 SAR-REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-GTGLGLAIVKRIVEAHGGTIWVES-EPGGGTTFTVT 233
|
....*
gi 447114342 877 LPIHP 881
Cdd:COG2205 234 LPLAE 238
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
487-881 |
1.00e-55 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 197.47 E-value: 1.00e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 487 LIAGRLASQLRQQVLSLKAANAYTTVMQDLARKLSSAVNLEEVMQTGRMTLETQLQTKVWISIRDKIISSDIELNDKEKV 566
Cdd:COG5002 1 LLLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 567 AAEWCLKHQQPCGRFTDTLSQSNWWFLPLLEQKNSLGIVGIYFKDEVVSLNFEQKKLTESVIEYIAQAALRTQLVNELEQ 646
Cdd:COG5002 81 LALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 647 AkvtsetERLRSALLSSVSHDLRSPLASIIGAADTLANfKAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGL 726
Cdd:COG5002 161 L------EQMRREFVANVSHELRTPLTSIRGYLELLLD-GAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGEL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 727 TLKRDWIGVDELIGSATRRLKRY--KPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQlSSED 804
Cdd:COG5002 234 KLEKEPVDLAELLEEVVEELRPLaeEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLR-EEDD 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447114342 805 EVKIEIEDKGAGIPEDERHRIFDMFYTIERGD-RGKFGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPIHP 881
Cdd:COG5002 313 QVRISVRDTGIGIPEEDLPRIFERFYRVDKSRsRETGGTGLGLAIVKHIVEAHGGRIWVES-EPGKGTTFTITLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
623-880 |
1.44e-51 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 183.96 E-value: 1.44e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 623 LTESVIEYIAQAALRTQLVNELEQAkvtsetERLRSALLSSVSHDLRSPLASIIGAADTLAnfkaEMTEQDQQDLLETIH 702
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEA------NEAKSRFLANVSHELRTPLTAIRGYLELLL----EELDEEQREYLETIL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 703 LEGERLDRYIQNLLDMTRLGHEGLTLKRDWIGVDELIGSATRRLKRY--KPDTQVVVQLPEQSISLYVHPALVEQAIFNV 780
Cdd:COG0642 152 RSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLaeEKGIELELDLPDDLPTVRGDPDRLRQVLLNL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 781 LENAANFSPPDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKfGTGLGLTIVKAIIGAHMGTI 860
Cdd:COG0642 232 LSNAIKYTPEGGTVTVSVR-REGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIVELHGGTI 309
|
250 260
....*....|....*....|
gi 447114342 861 EAFSgRQNKGTLIQIKLPIH 880
Cdd:COG0642 310 EVES-EPGKGTTFTVTLPLA 328
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
399-881 |
2.22e-35 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 141.46 E-value: 2.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 399 ESVFVLAVTCASIFIAHFAEVLFGIEDFSVIFIISVLIVATKTRMLAAVVAALICFLAYNFFFIAPRYTFQISAHQGVVT 478
Cdd:COG4251 18 LLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 479 VVAFFAAALIAGRLASQLRQQVLSLKAANAYTTVMQDLARKLSSAVNLEEVMQTGRMTLETQLQTKVWISIRDKIISSDI 558
Cdd:COG4251 98 LVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 559 ELNDKEKVAAEWCLKHQQPCGRFTDTLSQSNWWFLPLLEQKNSLGIVGIYFKDEVVSLNFEQKKLTESVIEYIAQAALRT 638
Cdd:COG4251 178 LELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLEL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 639 QLVNELEQAKVTSETERLRSA------LLSSVSHDLRSPLASIIGAADTLANFKAEMTEQDQQDLLETIHLEGERLDRYI 712
Cdd:COG4251 258 RLELEELEEELEERTAELERSneeleqFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLERIRDAAERMQALI 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 713 QNLLDMTRLGHEGLTLKrdWIGVDELIGSATRRLKRYKPDTQVVVQLPEqSISLYVHPALVEQAIFNVLENAANFSPPDE 792
Cdd:COG4251 338 DDLLAYSRVGRQELEFE--PVDLNELLEEVLEDLEPRIEERGAEIEVGP-LPTVRGDPTLLRQVFQNLISNAIKYSRPGE 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 793 S--VMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKfGTGLGLTIVKAIIGAHMGTIEAfSGRQNKG 870
Cdd:COG4251 415 PprIEIGAE-REGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE-GTGIGLAIVKKIVERHGGRIWV-ESEPGEG 491
|
490
....*....|.
gi 447114342 871 TLIQIKLPIHP 881
Cdd:COG4251 492 ATFYFTLPKAP 502
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
660-881 |
1.05e-34 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 137.79 E-value: 1.05e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 660 LLSSVSHDLRSPLASIIGAADTLANFKAEMTEQDQQDL---LETIHLEGERLDRYIQNLLDMTRLGheglTLKRDWIGVD 736
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLeraLDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLN 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 737 ELIGSATR--RLKRYKPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQLSsEDEVKIEIEDKG 814
Cdd:COG5000 280 ELLREVLAlyEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE-DGRVRIEVSDNG 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447114342 815 AGIPEDERHRIFDMFYTiergDRGKfGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPIHP 881
Cdd:COG5000 359 PGIPEEVLERIFEPFFT----TKPK-GTGLGLAIVKKIVEEHGGTIELES-RPGGGTTFTIRLPLAE 419
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
613-880 |
1.66e-33 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 132.61 E-value: 1.66e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 613 VVSLNFEQKKLTESVIEYIAQAALRTQLVNELEQAKVT-SETERLRS--ALLSSVSHDLRSPLASIIGAADTLAN-FKAE 688
Cdd:COG4191 95 LLLLAALDAEENAELEELERDITELERAEEELRELQEQlVQSEKLAAlgELAAGIAHEINNPLAAILGNAELLRRrLEDE 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 689 MTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEgltlKRDWIGVDELIGSATRRLKRY--KPDTQVVVQLPEQSISL 766
Cdd:COG4191 175 PDPEELREALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNELIDEALELLRPRlkARGIEVELDLPPDLPPV 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 767 YVHPALVEQAIFNVLENAANFSPPDES--VMIRAQLSsEDEVKIEIEDKGAGIPEDERHRIFDMFYTieRGDRGKfGTGL 844
Cdd:COG4191 251 LGDPGQLEQVLLNLLINAIDAMEEGEGgrITISTRRE-GDYVVISVRDNGPGIPPEVLERIFEPFFT--TKPVGK-GTGL 326
|
250 260 270
....*....|....*....|....*....|....*.
gi 447114342 845 GLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPIH 880
Cdd:COG4191 327 GLSISYGIVEKHGGRIEVES-EPGGGTTFTITLPLA 361
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
666-881 |
1.01e-32 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 133.05 E-value: 1.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 666 HDLRSPLASIIGAADTLANfkaEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLKRDWIGVDELI-----G 740
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQE---DPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLeelveA 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 741 SATRRLKRykpdtQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQLSsEDEVKIEIEDKGAGIPED 820
Cdd:PRK11100 342 REAQAAAK-----GITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVD-GEQVALSVEDQGPGIPDY 415
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447114342 821 ERHRIFDMFYTIERGDRGKFGTGLGLTIVKAIIGAHMGTIEaFSGRQNKGTLIQIKLPIHP 881
Cdd:PRK11100 416 ALPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVT-LRNRPEGGVLATLTLPRHF 475
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
637-884 |
2.73e-30 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 123.42 E-value: 2.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 637 RTQLVNELEQAkvtsetERLRSA--LLSSVSHDLRSPLASIIGAADTLANfkaEMTEQDQQDLLETIHLEGERLDRYIQN 714
Cdd:COG3852 119 RKRLERELRRA------EKLAAVgeLAAGLAHEIRNPLTGIRGAAQLLER---ELPDDELREYTQLIIEEADRLNNLVDR 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 715 LLDMTRLGHegltLKRDWIGVDELIGSATRRLK-RYKPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDES 793
Cdd:COG3852 190 LLSFSRPRP----PEREPVNLHEVLERVLELLRaEAPKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGT 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 794 VMIR---------AQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTiergdrGKF-GTGLGLTIVKAIIGAHMGTIEAF 863
Cdd:COG3852 266 ITIRtrverqvtlGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFT------TKEkGTGLGLAIVQKIVEQHGGTIEVE 339
|
250 260
....*....|....*....|.
gi 447114342 864 SgRQNKGTLIQIKLPIHPVKE 884
Cdd:COG3852 340 S-EPGKGTTFRIYLPLEQAEE 359
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
770-879 |
1.10e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 102.34 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 770 PALVEQAIFNVLENAANFSPPDESVMIRAQLSsEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKFGTGLGLTIV 849
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLERD-GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIV 81
|
90 100 110
....*....|....*....|....*....|
gi 447114342 850 KAIIGAHMGTIEaFSGRQNKGTLIQIKLPI 879
Cdd:smart00387 82 KKLVELHGGEIS-VESEPGGGTTFTITLPL 110
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
653-883 |
5.59e-25 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 110.83 E-value: 5.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 653 TERLRS--ALLSSVSHDLRSPLASIIGAADTLanfKAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLKR 730
Cdd:PRK11360 384 QERLAAlgELVAGVAHEIRNPLTAIRGYVQIW---RQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVS 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 731 dwigVDELIGSATRRLK--RYKPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQLSSEDEVKI 808
Cdd:PRK11360 461 ----LNALVEEVLQLFQtaGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAV 536
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447114342 809 EIEDKGAGIPEDERHRIFDMFYTIergdRGKfGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPIHPVK 883
Cdd:PRK11360 537 SIEDNGCGIDPELLKKIFDPFFTT----KAK-GTGLGLALSQRIINAHGGDIEVES-EPGVGTTFTLYLPINPQG 605
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
611-883 |
3.78e-24 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 106.94 E-value: 3.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 611 DEVVSLNFEQ-KKLTESVIEYIAQAALRTQLVNELEQakVTSETERLrsalLSSVSHDLRSPLASIIGAADTLANFKAEM 689
Cdd:PRK09470 202 DEVAQGNLRQhPELETGPQEFRQAGASFNQMVTALER--MMTSQQRL----LSDISHELRTPLTRLQLATALLRRRQGES 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 690 TEqdqqdlLETIHLEGERLDRYIQNLLDMTRLGH------EGLTLKRDWigvDELIGSATRRLKRYKPDTQVVVQLPEQS 763
Cdd:PRK09470 276 KE------LERIETEAQRLDSMINDLLVLSRNQQknhlerETFKANSLW---SEVLEDAKFEAEQMGKSLTVSAPPGPWP 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 764 IslYVHPALVEQAIFNVLENAANFSPPDESVMIRAQlssEDEVKIEIEDKGAGIPEDERHRIFDMFY-TIERGDRGKFGT 842
Cdd:PRK09470 347 I--NGNPNALASALENIVRNALRYSHTKIEVAFSVD---KDGLTITVDDDGPGVPEEEREQIFRPFYrVDEARDRESGGT 421
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 447114342 843 GLGLTIVKAIIGAHMGTIEAfSGRQNKGTLIQIKLPIHPVK 883
Cdd:PRK09470 422 GLGLAIVENAIQQHRGWVKA-EDSPLGGLRLTIWLPLYKRS 461
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
770-881 |
8.92e-24 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 96.67 E-value: 8.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 770 PALVEQAIFNVLENAANFSPPDESVMIRaqLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERgdRGKFGTGLGLTIV 849
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVT--LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK--RGGGGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|..
gi 447114342 850 KAIIGAHMGTIEAFSgRQNKGTLIQIKLPIHP 881
Cdd:pfam02518 79 RKLVELLGGTITVES-EPGGGTTVTLTLPLAQ 109
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
401-499 |
1.41e-23 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 95.99 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 401 VFVLAVTCASIFIAHFAEVLFGIEDFSVIFIISVLIVATKTRMLAAVVAALICFLAYNFFFIAPRYTFQISAHQGVVTVV 480
Cdd:pfam13493 2 LLAVLILALATLLALLLRPLLPLANIALLFLLAVLLVALRGGRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGYLLTLV 81
|
90
....*....|....*....
gi 447114342 481 AFFAAALIAGRLASQLRQQ 499
Cdd:pfam13493 82 VFLLVALLTSTLTARLRRQ 100
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
643-880 |
2.39e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 101.59 E-value: 2.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 643 ELEQAKVTSETERLRSALLSSVSHDLRSPLASIIGAADTLAnfkaEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLG 722
Cdd:COG5809 256 KLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLK----DTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 723 heglTLKRDWIGVDELIGSATRRL--KRYKPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQL 800
Cdd:COG5809 332 ----AIKYEPKDLNTLIEEVIPLLqpQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 801 SSEDEVKIEIEDKGAGIPEDERHRIFDMFYTI-ERgdrgkfGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPI 879
Cdd:COG5809 408 EDDDKVVISVTDEGCGIPEERLKKLGEPFYTTkEK------GTGLGLMVSYKIIEEHGGKITVES-EVGKGTTFSITLPI 480
|
.
gi 447114342 880 H 880
Cdd:COG5809 481 K 481
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
610-860 |
3.01e-20 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 93.86 E-value: 3.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 610 KDEVVSLNFEQKKLTESVIEYIAQAALRTQLVNELEQAKVTSET--ERLRSA--LLSSVSHDLRSPL--ASIigAADTLA 683
Cdd:PRK09303 100 QQEGATYSGLGENLQPSEIDSGRYSQELLQLSDELFVLRQENETllEQLKFKdrVLAMLAHDLRTPLtaASL--ALETLE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 684 ----NFKAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLKRDWIGVDELIGSATRRL------KRYKPDT 753
Cdd:PRK09303 178 lgqiDEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELekrwlaKSLEIQT 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 754 QVVVQLPeqsiSLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIE 833
Cdd:PRK09303 258 DIPSDLP----SVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLP 333
|
250 260
....*....|....*....|....*..
gi 447114342 834 RgDRGKFGTGLGLTIVKAIIGAHMGTI 860
Cdd:PRK09303 334 R-DEGTEGYGIGLSVCRRIVRVHYGQI 359
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
251-377 |
4.58e-20 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 86.53 E-value: 4.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 251 LMIAIDGQGSSEYLVRAGCRLAERYGATWTVVNVAksldfGQSSGNSYKKEYIEIDRAFELARQLGGRTEILYGHRVASV 330
Cdd:cd01987 2 ILVCISSSPTSEKLIRRAARLAERLNGELTAVYVE-----TPEESRLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEA 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 447114342 331 LMDAAVDRGISNLVIGKSISPWWLKLFKKNLAQQLLNQENSIALTIL 377
Cdd:cd01987 77 IVEFARERNVTQIVLGQSRRRRWRRLFKGSLVDRLLREAPNIDVHIV 123
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
657-879 |
6.10e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 93.44 E-value: 6.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 657 RSALLSSVSHDLRSPLASIigaadTLAnfkAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLKRDwigVD 736
Cdd:PRK09467 229 RTLLMAGVSHDLRTPLTRI-----RLA---TEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMAD---LN 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 737 ELIG-SATRRLKRykpDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDesvmirAQLSSEDE---VKIEIED 812
Cdd:PRK09467 298 ALLGeVIAAESGY---EREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGW------IKVSSGTEgkrAWFQVED 368
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447114342 813 KGAGIPEDERHRIFDMFytiERGD--RGKFGTGLGLTIVKAIIGAHMGTIEaFSGRQNKGTLIQIKLPI 879
Cdd:PRK09467 369 DGPGIPPEQLKHLFQPF---TRGDsaRGSSGTGLGLAIVKRIVDQHNGKVE-LGNSEEGGLSARAWLPL 433
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
770-861 |
1.21e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 84.82 E-value: 1.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 770 PALVEQAIFNVLENAANFSPPDESVMIRAQLSSEdEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKFGTGLGLTIV 849
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFSPEGGLIALQLEADTE-GIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80
|
90
....*....|..
gi 447114342 850 KAIIGAHMGTIE 861
Cdd:cd16945 81 QEVAQLHGGRIT 92
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
774-878 |
4.11e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 83.14 E-value: 4.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 774 EQAIFNVLENAANFSPPDESVMIRAQlssEDEVKIEIEDKGAGIPEDERHRIFDMFYTI-ERGDRGKFGTGLGLTIVKAI 852
Cdd:cd16949 2 ARALENVLRNALRYSPSKILLDISQD---GDQWTITITDDGPGVPEDQLEQIFLPFYRVdSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 447114342 853 IGAHMGTIEAfSGRQNKGTLIQIKLP 878
Cdd:cd16949 79 IEQHGGKIKA-SNRKPGGLRVRIWLP 103
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
609-879 |
5.14e-19 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 92.66 E-value: 5.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 609 FKDEVVSLNFEQKKLTESVIeyiAQAALRTQLVNELEQAKVTSE-TERLRSALLSSVSHDLRSPLASIIGAADTLANFKA 687
Cdd:PRK11466 398 FRSNVHALNRHREQLAAQVK---ARTAELQELVIEHRQARAEAEkASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPA 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 688 emtEQDQQDLLETIHLEGERLDRYIQNLLDMTRL--GHEGLTLKRDWIGVDELIGSATR----RLKRY--KPDTQVVVQL 759
Cdd:PRK11466 475 ---LNAQRDDLRAITDSGESLLTILNDILDYSAIeaGGKNVSVSDEPFEPRPLLESTLQlmsgRVKGRpiRLATDIADDL 551
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 760 PEqsiSLYVHPALVEQAIFNVLENAANFSppDESVMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIErGDRGk 839
Cdd:PRK11466 552 PT---ALMGDPRRIRQVITNLLSNALRFT--DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVS-GKRG- 624
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 447114342 840 fGTGLGLTIVKAIIGAHMGTIEAfSGRQNKGTLIQIKLPI 879
Cdd:PRK11466 625 -GTGLGLTISSRLAQAMGGELSA-TSTPEVGSCFCLRLPL 662
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
765-877 |
8.25e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 82.84 E-value: 8.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 765 SLYVH--PALVEQAIFNVLENAANFSPPDESVMIRaqLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYtieRGD-RGKFG 841
Cdd:cd16940 4 DIQVQgdALLLFLLLRNLVDNAVRYSPQGSRVEIK--LSADDGAVIRVEDNGPGIDEEELEALFERFY---RSDgQNYGG 78
|
90 100 110
....*....|....*....|....*....|....*.
gi 447114342 842 TGLGLTIVKAIIGAHMGTIEaFSGRQNKGTLIQIKL 877
Cdd:cd16940 79 SGLGLSIVKRIVELHGGQIF-LGNAQGGGLEAWVRL 113
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
775-878 |
4.81e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 80.23 E-value: 4.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 775 QAIFNVLENAANFSPpDESVMIRAQLSSEDE----VKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKF-GTGLGLTIV 849
Cdd:cd16922 3 QILLNLLGNAIKFTE-EGEVTLRVSLEEEEEdgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYgGTGLGLAIS 81
|
90 100
....*....|....*....|....*....
gi 447114342 850 KAIIGAHMGTIEAFSgRQNKGTLIQIKLP 878
Cdd:cd16922 82 KKLVELMGGDISVES-EPGQGSTFTFTLP 109
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
770-879 |
9.70e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 79.39 E-value: 9.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 770 PALVEQAIFNVLENAANFSPPDESVMIRAQLSsEDEVKIEIEDKGAGIPEDERHRIFDMFYTIER-GDrgkfGTGLGLTI 848
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAH-VDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvGE----GTGLGLSL 75
|
90 100 110
....*....|....*....|....*....|.
gi 447114342 849 VKAIIGAHMGTIEAFSgRQNKGTLIQIKLPI 879
Cdd:cd16943 76 SYRIIQKHGGTIRVAS-VPGGGTRFTIILPI 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
660-879 |
2.95e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 85.61 E-value: 2.95e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 660 LLSSVSHDLRSPLASIIGAADTLANfKAEMTEQDQQdLLETIHLEGERLDRYIQNLLDMTRLGHegLTLKRdwIGVDELI 739
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYFAE-RAPAGGEAHQ-LAQVMAKEADRLNRVVSELLELVKPTH--LALQA--VDLNDLI 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 740 GSATRRLKRYKPDTQVVVQL--PEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQlSSEDEVKIEIEDKGAGI 817
Cdd:PRK10364 314 NHSLQLVSQDANSREIQLRFtaNDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTAS-ESGAGVKISVTDSGKGI 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447114342 818 PEDERHRIFDMFYTIeRGDrgkfGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPI 879
Cdd:PRK10364 393 AADQLEAIFTPYFTT-KAE----GTGLGLAVVHNIVEQHGGTIQVAS-QEGKGATFTLWLPV 448
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
657-860 |
5.48e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 84.27 E-value: 5.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 657 RSALLSSVSHDLRSPLASIigaadtlaNFKAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLKRDWIGVD 736
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRL--------RYRLEMSDNLSAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 737 ELIGSATRRLKRYKPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSppdESVMIRAQLSSEDEVKIEIEDKGAG 816
Cdd:PRK10604 284 AWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA---HSRVRVSLLLDGNQACLIVEDDGPG 360
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 447114342 817 IPEDERHRIFDMFYTIERG-DRGKFGTGLGLTIVKAIIGAHMGTI 860
Cdd:PRK10604 361 IPPEERERVFEPFVRLDPSrDRATGGCGLGLAIVHSIALAMGGSV 405
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
632-879 |
8.61e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 85.46 E-value: 8.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 632 AQAALRTQlvnELEQAKVTSE-TERLRSALLSSVSHDLRSPLASIIGAADTLANfkAEMTEQdQQDLLETIHLEGERLDR 710
Cdd:PRK15347 375 NKVAERTQ---ALAEAKQRAEqANKRKSEHLTTISHEIRTPLNGVLGALELLQN--TPLTAE-QMDLADTARQCTLSLLA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 711 YIQNLLDMTRLGHEGLTLKRDWIGVDELIGSA---------TRRLKRYkpdTQVVVQLPEqsiSLYVHPALVEQAIFNVL 781
Cdd:PRK15347 449 IINNLLDFSRIESGQMTLSLEETALLPLLDQAmltiqgpaqSKSLTLR---TFVGAHVPL---YLHLDSLRLRQILVNLL 522
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 782 ENAANFSpPDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIergDRGKFGTGLGLTIVKAIigAHM--GT 859
Cdd:PRK15347 523 GNAVKFT-ETGGIRLRVK-RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQA---DTHSQGTGLGLTIASSL--AKMmgGE 595
|
250 260
....*....|....*....|
gi 447114342 860 IEAFSgRQNKGTLIQIKLPI 879
Cdd:PRK15347 596 LTLFS-TPGVGSCFSLVLPL 614
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
773-878 |
1.62e-16 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 75.99 E-value: 1.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 773 VEQAIFNVLENAANFSPPDESVMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTI-ERGDRGKFGTGLGLTIVKA 851
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGdGSSTRAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|....*..
gi 447114342 852 IIGAHMGTIeAFSGRQNKGTLIQIKLP 878
Cdd:cd16925 85 FVELHGGTV-TVSDAPGGGALFQVELP 110
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
775-878 |
7.97e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 74.15 E-value: 7.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 775 QAIFNVLENAANFSPPDESVMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTiERGDRGKFGT--GLGLTIVKAI 852
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYT-ERPANEAFGQhsGLGLSISRQI 81
|
90 100
....*....|....*....|....*....
gi 447114342 853 IGAHMGTIEAFSGRQN---KGTLIQIKLP 878
Cdd:cd16953 82 IEAHGGISVAENHNQPgqvIGARFTVQLP 110
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
637-879 |
2.30e-15 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 80.76 E-value: 2.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 637 RTQLVNELEQAkvtsetERLRSALLSSVSHDLRSPLASIIGAA----DTlanfkaEMTEQdQQDLLETIHLEGERLDRYI 712
Cdd:PRK11091 269 RKRYQDALEKA------SRDKTTFISTISHELRTPLNGIVGLSrillDT------ELTAE-QRKYLKTIHVSAITLGNIF 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 713 QNLLDMTRLGHEGLTL---KRDWIG-VDEL--IGSATRRLKRYKPDTQVVVQLPEQSIslyVHPALVEQAIFNVLENAAN 786
Cdd:PRK11091 336 NDIIDMDKMERRKLQLdnqPIDFTDfLADLenLSGLQAEQKGLRFDLEPLLPLPHKVI---TDGTRLRQILWNLISNAVK 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 787 FSPpDESVMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKF--GTGLGLTIVKAIIGAhMGTIEAFS 864
Cdd:PRK11091 413 FTQ-QGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPatGTGIGLAVSKRLAQA-MGGDITVT 490
|
250
....*....|....*..
gi 447114342 865 GRQNKGT--LIQIKLPI 879
Cdd:PRK11091 491 SEEGKGScfTLTIHAPA 507
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-878 |
1.69e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 70.26 E-value: 1.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 772 LVEQAIFNVLENAAN-----FSPPDEsVMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTiergDRGKfGTGLGL 846
Cdd:cd16944 4 QISQVLTNILKNAAEaiegrPSDVGE-VRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVT----TRPK-GTGLGL 77
|
90 100 110
....*....|....*....|....*....|..
gi 447114342 847 TIVKAIIGAHMGTIEaFSGRQNKGTLIQIKLP 878
Cdd:cd16944 78 AIVKKIMEEHGGRIS-LSNREAGGACIRIILP 108
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-878 |
2.39e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 69.72 E-value: 2.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 779 NVLENAANFSPPDESVMIRAQLSsEDEVKIEIEDKGAGIPEDERHRIFDMFYtieRGD--RGKFGTGLGLTIVKAIIGAH 856
Cdd:cd16923 7 NLLSNAIKYSPENTRIYITSFLT-DDVVNIMFKNPSSHPLDFKLEKLFERFY---RGDnsRNTEGAGLGLSIAKAIIELH 82
|
90 100
....*....|....*....|..
gi 447114342 857 MGTIEAFSgrQNKGTLIQIKLP 878
Cdd:cd16923 83 GGSASAEY--DDNHDLFKVRLP 102
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-878 |
2.68e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.40 E-value: 2.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 773 VEQAIFNVLENAANFSppDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYtieRGD--RGKFGTGLGLTIVK 850
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSD-GEGNRTRIQVLDNGPGIAPEEVDELFQPFY---RGDnaRGTSGTGLGLAIVQ 74
|
90 100
....*....|....*....|....*...
gi 447114342 851 AIIGAHMGTIEaFSGRQNKGTLIQIKLP 878
Cdd:cd16950 75 RISDAHGGSLT-LANRAGGGLCARIELP 101
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-878 |
3.52e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 69.35 E-value: 3.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 773 VEQAIFNVLENA--ANFSPPDES--VMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIErgdrgKFGTGLGLTI 848
Cdd:cd16920 1 IQQVLINLVRNGieAMSEGGCERreLTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTK-----SEGLGMGLSI 75
|
90 100 110
....*....|....*....|....*....|
gi 447114342 849 VKAIIGAHMGTIeAFSGRQNKGTLIQIKLP 878
Cdd:cd16920 76 CRSIIEAHGGRL-SVESPAGGGATFQFTLP 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
643-884 |
4.80e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 76.70 E-value: 4.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 643 ELEQAKVTSETERlRSALLSSVSHDLRSPLASIIGAADTLANfkAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLG 722
Cdd:PRK09959 699 EVERNKAINATVA-KSQFLATMSHEIRTPISSIMGFLELLSG--SGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIE 775
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 723 HEGLTLKRDWIGVDELIGSATRRLKRYKPDTQVVVQ----LPEQSIsLYVHPALVEQAIFNVLENAANFSpPDESVMIRA 798
Cdd:PRK09959 776 SGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsstFPDHYL-VKIDPQAFKQVLSNLLSNALKFT-TEGAVKITT 853
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 799 QLSSEDE----VKIEIEDKGAGIPEDERHRIFDMFYTIERGdRGKFGTGLGLTIVKAIIGAHMGTIeAFSGRQNKGTLIQ 874
Cdd:PRK09959 854 SLGHIDDnhavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAG-RQQTGSGLGLMICKELIKNMQGDL-SLESHPGIGTTFT 931
|
250
....*....|
gi 447114342 875 IKLPIHPVKE 884
Cdd:PRK09959 932 ITIPVEISQQ 941
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
607-879 |
1.00e-13 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 74.11 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 607 IYFKDEVVSLNFEQKKLTESVIEYIAQAALRTQ---LVNELEQAKVTSETerlrsalLSSVSHDLRSPLASIIGaadtla 683
Cdd:COG3290 143 ILLNGRVLVVNRVPIRDDGRVVGAVATFRDRTElerLEEELEGVKELAEA-------LRAQRHDFRNHLHTISG------ 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 684 nfkaemteqdqqdLLETIHLEgeRLDRYIQNLLDMTRLGHEGLTLKRDWIGVDELIGSATRRLKRYKPDTQVVV--QLPE 761
Cdd:COG3290 210 -------------LLQLGEYD--EALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIdsDLPD 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 762 QSISlyvhPALVEQAIFNVLENA---ANFSPPDE---SVMIRaqlSSEDEVKIEIEDKGAGIPEDERHRIFDM-FYTier 834
Cdd:COG3290 275 LPLS----DTDLVTILGNLLDNAieaVEKLPEEErrvELSIR---DDGDELVIEVEDSGPGIPEELLEKIFERgFST--- 344
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 447114342 835 gdRGKFGTGLGLTIVKAIIGAHMGTIEaFSGRQNKGTLIQIKLPI 879
Cdd:COG3290 345 --KLGEGRGLGLALVKQIVEKYGGTIE-VESEEGEGTVFTVRLPK 386
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
664-860 |
1.69e-13 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 74.04 E-value: 1.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 664 VSHDLRSPLASIIgaADTLANFKAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLKRDWIGVDELIGSAT 743
Cdd:PRK09835 269 IAHEIRTPITNLI--TQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVF 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 744 RRLKRYKPDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERH 823
Cdd:PRK09835 347 DFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQ-EVDHQVQLVVENPGTPIAPEHLP 425
|
170 180 190
....*....|....*....|....*....|....*....
gi 447114342 824 RIFDMFYTIE--RGDRGKfGTGLGLTIVKAIIGAHMGTI 860
Cdd:PRK09835 426 RLFDRFYRVDpsRQRKGE-GSGIGLAIVKSIVVAHKGTV 463
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
654-720 |
2.12e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 65.70 E-value: 2.12e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447114342 654 ERLRSALLSSVSHDLRSPLASIIGAADTLANfkAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTR 720
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEE--ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
639-881 |
3.58e-13 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 72.74 E-value: 3.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 639 QLVNELEQakvtseTERLRSALLSSVSHDLRSPLASIIGAADTLanfkaemteQD--QQDLLETIH-LEGE--RLDRYIQ 713
Cdd:PRK10549 228 QLASTLEK------NEQMRRDFMADISHELRTPLAVLRGELEAI---------QDgvRKFTPESVAsLQAEvgTLTKLVD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 714 NL--LDMTRLGheGLTLKRDWIGVDELI---GSATRRLKRYKPDTqVVVQLPEQsISLYVHPALVEQAIFNVLENAANFS 788
Cdd:PRK10549 293 DLhqLSLSDEG--ALAYRKTPVDLVPLLevaGGAFRERFASRGLT-LQLSLPDS-ATVFGDPDRLMQLFNNLLENSLRYT 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 789 PPDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERG-DRGKFGTGLGLTIVKAIIGAHMGTIEA----F 863
Cdd:PRK10549 369 DSGGSLHISAE-QRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSrNRASGGSGLGLAICLNIVEAHNGRIIAahspF 447
|
250
....*....|....*...
gi 447114342 864 SGRQnkgtlIQIKLPIHP 881
Cdd:PRK10549 448 GGVS-----ITVELPLER 460
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
774-862 |
4.30e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 66.33 E-value: 4.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 774 EQAIFNVLENAANFSPPDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERG-DRGKFGTGLGLTIVKAI 852
Cdd:cd16946 6 QQLFVNLLENSLRYTDTGGKLRIRAA-QTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrNRASGGSGLGLAICHNI 84
|
90
....*....|
gi 447114342 853 IGAHMGTIEA 862
Cdd:cd16946 85 ALAHGGTISA 94
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
657-724 |
5.40e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 64.54 E-value: 5.40e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447114342 657 RSALLSSVSHDLRSPLASIIGAADTLANFKaemTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHE 724
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEK---LDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
653-879 |
5.63e-13 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 72.46 E-value: 5.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 653 TERLRSA--LLSSVSHDLRSPLASIIGaadTLANFKAEMTEQDqqDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLkr 730
Cdd:COG5805 281 SEKLSIAgqLAAGIAHEIRNPLTSIKG---FLQLLQPGIEDKE--EYFDIMLSELDRIESIISEFLALAKPQAVNKEK-- 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 731 dwIGVDELIGS------ATRRLKrykpDTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPDESVMIRAQLSsED 804
Cdd:COG5805 354 --ENINELIQDvvtlleTEAILH----NIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEE-DN 426
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447114342 805 EVKIEIEDKGAGIPEDERHRIFDMFYTIErgdrgKFGTGLGLTIVKAIIGAHMGTIEaFSGRQNKGTLIQIKLPI 879
Cdd:COG5805 427 SVIIRVIDEGIGIPEERLKKLGEPFFTTK-----EKGTGLGLMVSYKIIENHNGTID-IDSKVGKGTTFTITLPL 495
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
639-878 |
1.22e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 70.38 E-value: 1.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 639 QLVNELEQakvTSETERLRSAllsSVSHDLRSPLASIigaadtlaNFKAEMTEQ----DQQDLLETIhlegERLDRYIQN 714
Cdd:PRK10755 125 QLVSRLTS---TLDQERLFTA---DVAHELRTPLAGI--------RLHLELLEKqhhiDVAPLIARL----DQMMHTVEQ 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 715 LLDMTRLGHE---GLTLKRDWigVDELIGSATRRLKRYKPDTQVVVQLPEQSISLYVH--PALVEQAIFNVLENAANFSP 789
Cdd:PRK10755 187 LLQLARAGQSfssGHYQTVKL--LEDVILPSQDELSEMLEQRQQTLLLPESAADITVQgdATLLRLLLRNLVENAHRYSP 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 790 PDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYtieRGDRGKFGTGLGLTIVKAIIGAHMGTIEAFSGRQNK 869
Cdd:PRK10755 265 EGSTITIKLS-QEDGGAVLAVEDEGPGIDESKCGELSKAFV---RMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERS 340
|
....*....
gi 447114342 870 GTLIQIKLP 878
Cdd:PRK10755 341 GTRAWVWLP 349
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
657-724 |
3.70e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 62.20 E-value: 3.70e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447114342 657 RSALLSSVSHDLRSPLASIIGAADTLANfkAEMTEqDQQDLLETIHLEGERLDRYIQNLLDMTRLGHE 724
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLD--TELSE-EQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-878 |
5.05e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 63.19 E-value: 5.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 773 VEQAIFNVLENAANFSPP-DESVMIRAQ------LSSEDE---VKIEIEDKGAGIPEDERHRIFDMFYTIERGdrgkfGT 842
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRtqrqvtLGHPRHrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGREN-----GT 75
|
90 100 110
....*....|....*....|....*....|....*.
gi 447114342 843 GLGLTIVKAIIGAHMGTIEAFSgrQNKGTLIQIKLP 878
Cdd:cd16918 76 GLGLAIAQNIVSQHGGVIECDS--QPGHTVFSVSLP 109
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
624-881 |
1.64e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 68.17 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 624 TESVIEYIAQAALRTQ---LVNELEQAkvtsetERLRS--ALLSSVSHDLRSPLASIIGAADtLANFKAEMTEQDQQDLL 698
Cdd:PRK13837 418 LDCLAHAIERRRLETErdaLERRLEHA------RRLEAvgTLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYID 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 699 ETIHlEGERLDRYIQNLLDMTRLGHegLTLKRdwIGVDELIGSATRRLKRYKPDT-QVVVQLPEQSISLYVHPALVEQAI 777
Cdd:PRK13837 491 EIIS-AGARARLIIDQILAFGRKGE--RNTKP--FDLSELVTEIAPLLRVSLPPGvELDFDQDQEPAVVEGNPAELQQVL 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 778 FNVLENAANFSPPDESVMI---RAQLSSEDE-----------VKIEIEDKGAGIPEDERHRIFDMFYTIERGdrgkfGTG 843
Cdd:PRK13837 566 MNLCSNAAQAMDGAGRVDIslsRAKLRAPKVlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFTTRAG-----GTG 640
|
250 260 270
....*....|....*....|....*....|....*...
gi 447114342 844 LGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPIHP 881
Cdd:PRK13837 641 LGLATVHGIVSAHAGYIDVQS-TVGRGTRFDVYLPPSS 677
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-877 |
3.05e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 61.38 E-value: 3.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 754 QVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSppDESVMIRAQLSS-EDEVKIEIEDKGAGIPEDERHRIFDMFYTI 832
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYG--SDGKFLGMTLREdEKHVYIDIWDKGKGISETEKDHVFERLYTL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 447114342 833 ERG-DRGKFGTGLGLTIVKAIIGAhMGTIEAFSGRQNKGTLIQIKL 877
Cdd:cd16947 80 EDSrNSAKQGNGLGLTITKRLAES-MGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
776-856 |
3.63e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 60.68 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 776 AIFNVLENAANFSPPDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIER-GDRGKFGTGLGLTIVKAIIG 854
Cdd:cd16952 4 AFSNLVSNAVKYTPPSDTITVRWS-QEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIeRCRNTGGTGLGLAIVKHVMS 82
|
..
gi 447114342 855 AH 856
Cdd:cd16952 83 RH 84
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
622-883 |
4.29e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 66.92 E-value: 4.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 622 KLTESVIEyIAQAAlrtqlvnelEQAkvtSETerlRSALLSSVSHDLRSPLASIIGAADTLanfKAEMTEQDQQDLLETI 701
Cdd:PRK10841 428 KMEESLQE-MAQAA---------EQA---SQS---KSMFLATVSHELRTPLYGIIGNLDLL---QTKELPKGVDRLVTAM 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 702 HLEGERLDRYIQNLLDMTRLGHEGLTLKRDWIGVDELIGSAT---------RRLKRY---KPDTQVvvqlpeqsiSLYVH 769
Cdd:PRK10841 489 NNSSSLLLKIISDILDFSKIESEQLKIEPREFSPREVINHITanylplvvkKRLGLYcfiEPDVPV---------ALNGD 559
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 770 PALVEQAIFNVLENAANFSppDESVMIRAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKF-GTGLGLTI 848
Cdd:PRK10841 560 PMRLQQVISNLLSNAIKFT--DTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFqGTGLGLAI 637
|
250 260 270
....*....|....*....|....*....|....*
gi 447114342 849 VKAIIGAHMGTIEAFSgRQNKGTLIQIKLPIHPVK 883
Cdd:PRK10841 638 CEKLINMMDGDISVDS-EPGMGSQFTIRIPLYGAQ 671
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
661-862 |
5.38e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 65.81 E-value: 5.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 661 LSSVSHDLRSPLASIIGAADTLANFKAEMTEQDQQDLLETIhlegERLDRYIQNLLDMTRLGHEGLTLKRDWIGVDELIG 740
Cdd:PRK10815 270 LTDLTHSLKTPLAVLQSTLRSLRSGKQMSVEQAEPIMLEQI----SRISQQIGYYLHRASMRSEHNLLSRELHSVAPLLD 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 741 SATRRLKRykpdtqvVVQLPEQSISLYVHPALV---EQAIF-----NVLENAANFSPpdESVMIRAQLSsEDEVKIEIED 812
Cdd:PRK10815 346 NLTSALNK-------VYQRKGVNITLDISPEITfvgEKNDFmevmgNVLDNACKYCL--EFVEISARQT-DEHLHIVVED 415
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 447114342 813 KGAGIPEDERHRIFDmfytieRGDRG---KFGTGLGLTIVKAIIGAHMGTIEA 862
Cdd:PRK10815 416 DGPGIPESKRELIFD------RGQRAdtlRPGQGLGLSVAREITEQYEGKISA 462
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-862 |
3.32e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 57.83 E-value: 3.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 773 VEQAIFNVLENAANFSppDESVMIrAQLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERG-DRGKFGTGLGLTIVKA 851
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRI-ALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSrDRATGGFGLGLAIVHR 77
|
90
....*....|.
gi 447114342 852 IIGAHMGTIEA 862
Cdd:cd16939 78 VALWHGGHVEC 88
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-878 |
4.49e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 57.34 E-value: 4.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 773 VEQAIFNVLENAANFSPPDESVMIRAQLSSE-DEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKfGTGLGLTIVKA 851
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVgEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYE-GTGVGLAIVRK 79
|
90 100
....*....|....*....|....*..
gi 447114342 852 IIGAHMGTIEAFSGrQNKGTLIQIKLP 878
Cdd:cd16921 80 IIERHGGRIWLESE-PGEGTTFYFTLP 105
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
660-879 |
6.82e-10 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 61.64 E-value: 6.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 660 LLSSVSHDLRSPLASIIGAADTLANFKAEmteqdqQDLLETIHLEGERLDRyIQNLLDmtRLghegLTLKRDWIGVDELI 739
Cdd:PRK11073 133 LVRGLAHEIKNPLGGLRGAAQLLSKALPD------PALTEYTKVIIEQADR-LRNLVD--RL----LGPQRPGTHVTESI 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 740 GSATRRLKRY----KPDTQVVVQ-----LPEqsisLYVHPALVEQAIFNVLENAAN-FSPPDESVMIRA----QLSSEDE 805
Cdd:PRK11073 200 HKVAERVVQLvsleLPDNVRLIRdydpsLPE----LAHDPDQIEQVLLNIVRNALQaLGPEGGTITLRTrtafQLTLHGE 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 806 -----VKIEIEDKGAGIPEDerhrIFD-MFYTIERGDRGkfGTGLGLTIVKAIIGAHMGTIEAFS--GRqnkgTLIQIKL 877
Cdd:PRK11073 276 ryrlaARIDIEDNGPGIPPH----LQDtLFYPMVSGREG--GTGLGLSIARNLIDQHSGKIEFTSwpGH----TEFSVYL 345
|
..
gi 447114342 878 PI 879
Cdd:PRK11073 346 PI 347
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-860 |
2.66e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 56.10 E-value: 2.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 779 NVLENAANFSppDESVMIRAQLSSEDeVKIEIEDKGAGIPEDERHRIFDMFytiERGDRGKFGTGLGLTIVKAIIGAHMG 858
Cdd:cd16954 44 NLLDNACKWC--LEFVEVTARQTDGG-LHLIVDDDGPGVPESQRSKIFQRG---QRLDEQRPGQGLGLAIAKEIVEQYGG 117
|
..
gi 447114342 859 TI 860
Cdd:cd16954 118 EL 119
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
640-856 |
2.73e-09 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 60.43 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 640 LVNELEQ--AKVTSETERLRSaLLSSVSHDLRSPLASIIGAADT--LANFKAEMteqdQQDLLETIHLEGERLDRYIQNL 715
Cdd:PRK10337 219 LVEALNQlfARTHAMMVRERR-FTSDAAHELRSPLAALKVQTEVaqLSDDDPQA----RKKALLQLHAGIDRATRLVDQL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 716 LDMTRLGHEGLTLKRDWIGVDELIGSATrrLKRYKP----DTQVVVQLPEQSISLYVHPALVEQAIFNVLENAANFSPPD 791
Cdd:PRK10337 294 LTLSRLDSLDNLQDVAEIPLEDLLQSAV--MDIYHTaqqaGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQG 371
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447114342 792 ESVMIRAqlsseDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDrgKFGTGLGLTIVKAIIGAH 856
Cdd:PRK10337 372 SVVDVTL-----NARNFTVRDNGPGVTPEALARIGERFYRPPGQE--ATGSGLGLSIVRRIAKLH 429
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
774-878 |
2.81e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 55.46 E-value: 2.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 774 EQAIFNVLENAANFSPPDESVMIRA--------------QLSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIErgDRGK 839
Cdd:cd16919 2 ELAILNLAVNARDAMPEGGRLTIETsnqrvdadyalnyrDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTK--EVGK 79
|
90 100 110
....*....|....*....|....*....|....*....
gi 447114342 840 fGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLP 878
Cdd:cd16919 80 -GTGLGLSMVYGFVKQSGGHLRIYS-EPGVGTTVRIYLP 116
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-860 |
9.25e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 53.61 E-value: 9.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 773 VEQAIFNVLENAANFSPPDESVMIRAQLSSE-DEVKIEIEDKGAGIPEDERHRIFDMFYTIErgDRGKfGTGLGLTIVKA 851
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLgGRLVLVVRDNGPGIAEEHLSRVFDPFFTTK--PVGK-GTGLGLSISYG 77
|
....*....
gi 447114342 852 IIGAHMGTI 860
Cdd:cd16976 78 IVEEHGGRL 86
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
643-882 |
1.01e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 59.09 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 643 ELEQAKVTS-ETERLRSALLSSVSHDLRSPLASIIGAADTLanFKAEMTEqDQQDLLETIHLEGERLDRYIQNLLDMTRL 721
Cdd:PRK11107 278 ELDLAKKRAqEAARIKSEFLANMSHELRTPLNGVIGFTRQT--LKTPLTP-TQRDYLQTIERSANNLLAIINDILDFSKL 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 722 GHEGLTLK------RDWIgvDELI----GSAtrRLKRYKPDTQVVVQLPEQSISlyvHPALVEQAIFNVLENAANFSPpD 791
Cdd:PRK11107 355 EAGKLVLEnipfslRETL--DEVVtllaHSA--HEKGLELTLNIDPDVPDNVIG---DPLRLQQIITNLVGNAIKFTE-S 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 792 ESVMIRAQLSSEDEVKIEIE----DKGAGIPEDERHRIFDMF----YTIERgdrgKFG-TGLGLTIVKAIIGAHMGTIEa 862
Cdd:PRK11107 427 GNIDILVELRALSNTKVQLEvqirDTGIGISERQQSQLFQAFrqadASISR----RHGgTGLGLVITQKLVNEMGGDIS- 501
|
250 260
....*....|....*....|....
gi 447114342 863 FSGRQNKGTL----IQIKLPIHPV 882
Cdd:PRK11107 502 FHSQPNRGSTfwfhLPLDLNPNPI 525
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
654-878 |
1.32e-08 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 58.10 E-value: 1.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 654 ERLRSALLSSVSHDLRSPLASIIGAAdtlanfkaEMTEQD------QQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLT 727
Cdd:PRK11006 201 EGARRNFFANVSHELRTPLTVLQGYL--------EMMQDQplegalREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTI 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 728 LKRDWIGVDELIgsatRRLKRykpDTQVVVQlPEQSISLYVHPALV-----EQ---AIFNVLENAANFSPPDESVMIRAQ 799
Cdd:PRK11006 273 DLNEKVDVPMML----RVLER---EAQTLSQ-GKHTITFEVDNSLKvfgneDQlrsAISNLVYNAVNHTPEGTHITVRWQ 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 800 LSSEDeVKIEIEDKGAGIPEDERHRIFDMFYTIERG-DRGKFGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLP 878
Cdd:PRK11006 345 RVPQG-AEFSVEDNGPGIAPEHIPRLTERFYRVDKArSRQTGGSGLGLAIVKHALSHHDSRLEIES-EVGKGTRFSFVLP 422
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
776-878 |
1.57e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 53.06 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 776 AIFNVLENAANFSPPDESVMIRAQlSSEDEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKFGTGLGLTIVKAIIGA 855
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLVKKLCDK 87
|
90 100
....*....|....*....|...
gi 447114342 856 HMGTIEAFSgRQNKGTLIQIKLP 878
Cdd:cd16948 88 LGHKIDVES-EVGEGTTFTITFP 109
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
779-878 |
4.81e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 51.52 E-value: 4.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 779 NVLENA--ANFSPPDESVMIRAQLSSE-DEVKIEIEDKGAGIPEDERHRIFDM-FYTIERGDRgkfgtGLGLTIVKAIIG 854
Cdd:cd16915 7 NLIDNAldALAATGAPNKQVEVFLRDEgDDLVIEVRDTGPGIAPELRDKVFERgVSTKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|....
gi 447114342 855 AHMGTIEAFSGrQNKGTLIQIKLP 878
Cdd:cd16915 82 RLGGSITVESE-PGGGTTFSIRIP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
768-879 |
3.10e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.91 E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 768 VHPALVEQAIFNVLENAANFSPPDESVMIRAQ---LSSEDE-----------VKIEIEDKGAGIPEDERHRIFDMFYTIE 833
Cdd:PRK13557 273 IDPTQAEVALLNVLINARDAMPEGGRVTIRTRnveIEDEDLamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTK 352
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 447114342 834 rgDRGKfGTGLGLTIVKAIIGAHMGTIEAFSgRQNKGTLIQIKLPI 879
Cdd:PRK13557 353 --EEGK-GTGLGLSMVYGFAKQSGGAVRIYS-EVGEGTTVRLYFPA 394
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
598-879 |
7.32e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 52.71 E-value: 7.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 598 QKNSLGIVGIYFKDEVVSLNFEQKKLTESVIEYIAQaalrtqlVNELEQAKVTSETERLRSALLSsvsHDLRSPLASIig 677
Cdd:COG2972 196 EKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEE-------VYELELEKKEAELKALQAQINP---HFLFNTLNSI-- 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 678 aadtlanfkAEMTEQDQQdlletihlegERLDRYIQNLLDMTRLGhegLTLKRDWIGVDELIGSATRRLK----RYKPDT 753
Cdd:COG2972 264 ---------RWLAELEDP----------EEAEEMLEALSKLLRYS---LSKGDELVTLEEELELIKSYLEiqklRFGDRL 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 754 QVVVQLPEQSISLYVhPA-----LVEQAIFNVLENaanfSPPDESVMIRAQLSsEDEVKIEIEDKGAGIPEDERHRIFDM 828
Cdd:COG2972 322 EVEIEIDEELLDLLI-PKlilqpLVENAIEHGIEP----KEGGGTIRISIRKE-GDRLVITVEDNGVGMPEEKLEKLLEE 395
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 447114342 829 FYTIERgdrgkfGTGLGLTIVKAIIGAHMG---TIEAFSgRQNKGTLIQIKLPI 879
Cdd:COG2972 396 LSSKGE------GRGIGLRNVRERLKLYYGeeyGLEIES-EPGEGTTVTIRIPL 442
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-860 |
9.17e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 48.23 E-value: 9.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 772 LVEQAIFNVLENAANFSPPDESVMIRAQLSSEdEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKFGTGLGLTIVKA 851
Cdd:cd16975 4 LLSRALINIISNACQYAPEGGTVSISIYDEEE-YLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKN 82
|
....*....
gi 447114342 852 IIGAHMGTI 860
Cdd:cd16975 83 LVEKHGGSL 91
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
623-860 |
1.75e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 48.53 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 623 LTESVIEYIAQAALRTQ-LVNELEQAKVTSEteRLRSA---------------LLSSVSHDLRSPLASIIGAADTLAnfK 686
Cdd:COG4192 385 IARLLRVFRDQAIEKTQeLETEIEERKRIEK--NLRQTqdeliqaakmavvgqTMTSLAHELNQPLNAMSMYLFSAK--K 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 687 AEMTEQDQQ--DLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLkrdwIGVDELIGSATRRLK-RYKPDtQVVVQLPeQS 763
Cdd:COG4192 461 ALEQENYAQlpTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVEsRAKPQ-QITLHIP-DD 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 764 ISLYVHPALVEQAIFNVLENAANFSPPDESVMIrAQLSSEDEVKIEIEDKGAGIPEDERhrIFDMFYTIErgdrgKFGTG 843
Cdd:COG4192 535 LMVQGDQVLLEQVLVNLLVNALDAVATQPQISV-DLLSNAENLRVAISDNGNGWPLVDK--LFTPFTTTK-----EVGLG 606
|
250
....*....|....*..
gi 447114342 844 LGLTIVKAIIGAHMGTI 860
Cdd:COG4192 607 LGLSICRSIMQQFGGDL 623
|
|
| Usp |
pfam00582 |
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ... |
251-346 |
5.66e-05 |
|
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.
Pssm-ID: 425765 [Multi-domain] Cd Length: 137 Bit Score: 43.94 E-value: 5.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 251 LMIAIDGQGSSEYLVRAGCRLAERYGATWTVVNVAKSLDFGQSSG----------NSYKKEYIEIDRAFELARQLGGRTE 320
Cdd:pfam00582 1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLadesaeeeelELELAEAEALAAAAAAEAGGVKVEV 80
|
90 100
....*....|....*....|....*.
gi 447114342 321 ILYGHRVASVLMDAAVDRGISNLVIG 346
Cdd:pfam00582 81 VVVVGDPAEEILEVAEEEDADLIVMG 106
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
779-878 |
7.44e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 46.36 E-value: 7.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 779 NVLENA--ANFSPPDESVMIRAQLSSE-DEVKIEIEDKGAGIPEDERHRIFDMFYTIERGDRGKFgtGLGLTIVKAIIGA 855
Cdd:PRK15053 439 NLLDNAfeASLRSDEGNKIVELFLSDEgDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEH--GIGLYLIASYVTR 516
|
90 100
....*....|....*....|...
gi 447114342 856 HMGTIeAFSGRQNKGTLIQIKLP 878
Cdd:PRK15053 517 CGGVI-TLEDNDPCGTLFSIFIP 538
|
|
| UspA |
COG0589 |
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms]; |
252-346 |
1.13e-04 |
|
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
Pssm-ID: 440354 Cd Length: 136 Bit Score: 42.99 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 252 MIAIDGQGSSEYLVRAGCRLAERYGATWTVVNVAKSLDFGQSSGNSYKKEYIE-----IDRAFELARQLGG--RTEILYG 324
Cdd:COG0589 6 LVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELEEELREeaeeaLEEAAERLEEAGVevETVVREG 85
|
90 100
....*....|....*....|..
gi 447114342 325 HrVASVLMDAAVDRGISNLVIG 346
Cdd:COG0589 86 D-PAEAILEAAEELDADLIVMG 106
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
771-852 |
2.93e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 38.74 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 771 ALVEqAIFNVLEnAANFSPPDESVMIRAQLSsEDEVKIEIEDKGAGIPEDErhrifdmfytIERGDRGKFGTGLGLTIVK 850
Cdd:COG2172 38 AVSE-AVTNAVR-HAYGGDPDGPVEVELELD-PDGLEIEVRDEGPGFDPED----------LPDPYSTLAEGGRGLFLIR 104
|
..
gi 447114342 851 AI 852
Cdd:COG2172 105 RL 106
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
633-881 |
5.59e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.60 E-value: 5.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 633 QAALRTQLVNELEQAKvtsETERLRSA--LlssvsHDlrsplasIIGAADTLANFKAEMTEQDQQDLLETIHLEGERLDR 710
Cdd:COG4585 35 AAELERELAARAEEAR---EEERRRIAreL-----HD-------GVGQSLSAIKLQLEAARRLLDADPEAAREELEEIRE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 711 YIQNLLDMTR-----LGHEGLtlkrDWIGVDELIGSATRRLKRyKPDTQVVVQLPEQSISLyvhPALVEQAIFNV----L 781
Cdd:COG4585 100 LAREALAELRrlvrgLRPPAL----DDLGLAAALEELAERLLR-AAGIRVELDVDGDPDRL---PPEVELALYRIvqeaL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 782 ENAANFSPPDEsVMIRAQLSsEDEVKIEIEDKGAGIPEDERHrifdmfytiergdrgkfGTGLGLTIVKAIIGAHMGTIE 861
Cdd:COG4585 172 TNALKHAGATR-VTVTLEVD-DGELTLTVRDDGVGFDPEAAP-----------------GGGLGLRGMRERAEALGGTLT 232
|
250 260
....*....|....*....|
gi 447114342 862 AFSgRQNKGTLIQIKLPIHP 881
Cdd:COG4585 233 IGS-APGGGTRVRATLPLAA 251
|
|
| Voltage_CLC |
pfam00654 |
Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane ... |
409-490 |
8.87e-03 |
|
Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains.
Pssm-ID: 425802 [Multi-domain] Cd Length: 344 Bit Score: 39.45 E-value: 8.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114342 409 ASIFIAHFAEVLFGIE----DFSVIFIISVLIvatktrmlAAVVAALICFLaynFFFIAPRYTFQISAHQGVVTVVAFFA 484
Cdd:pfam00654 99 AAAFNAPLAGVLFALEelsrSFSLRALIPVLL--------ASVVAALVSRL---IFGNSPLFSVGEPGSLSLLELPLFIL 167
|
....*.
gi 447114342 485 AALIAG 490
Cdd:pfam00654 168 LGILCG 173
|
|
| |
