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Conserved domains on  [gi|447114864|ref|WP_001192120|]
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MULTISPECIES: carbohydrate ABC transporter permease [Streptococcus]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 30-279 7.94e-94

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 278.13  E-value: 7.94e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  30 PFYWILTGAFKSQPDTIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQR 109
Cdd:COG0395   31 PLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLAAYALARFRFRGRK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 110 ILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLI--GWPFGVFLMKQFSENIPTELLESAKIDGCGEIRTFW 187
Cdd:COG0395  111 LLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLafGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFW 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 188 SVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKS 267
Cdd:COG0395  191 RIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGTDWGLLMAAAVIATLPVLILFLFLQRY 270

                        250
                 ....*....|..
gi 447114864 268 FTQGITMGAVKG 279
Cdd:COG0395  271 FVRGLTAGAVKG 282
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 30-279 7.94e-94

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 278.13  E-value: 7.94e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  30 PFYWILTGAFKSQPDTIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQR 109
Cdd:COG0395   31 PLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLAAYALARFRFRGRK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 110 ILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLI--GWPFGVFLMKQFSENIPTELLESAKIDGCGEIRTFW 187
Cdd:COG0395  111 LLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLafGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFW 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 188 SVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKS 267
Cdd:COG0395  191 RIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGTDWGLLMAAAVIATLPVLILFLFLQRY 270

                        250
                 ....*....|..
gi 447114864 268 FTQGITMGAVKG 279
Cdd:COG0395  271 FVRGLTAGAVKG 282
ABC_arch_GlcU NF040932
glucose ABC transporter permease GlcU;
30-272 2.27e-33

glucose ABC transporter permease GlcU;


Pssm-ID: 468865  Cd Length: 272  Bit Score: 122.81  E-value: 2.27e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  30 PFYWILTGAFKSQPDTIVIPPQWFPKMPTMENFQQlmVQNPALQWMWNSVFISLVTMFLVCATSSLAGY---VLAKKRFY 106
Cdd:NF040932  19 PLYAMVINGLKSNFEVLSTPVLVPPSKPTLSAYYT--VWSGLAPPLINSLIVVIPVALISTFLGAMGAYffyRLSERHSI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 107 GQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGW--PFGVFLMKQFSENIPTELLESAKIDGCGEIR 184
Cdd:NF040932  97 LSDFLFSLIALATFIPYQATLVPLTRLEVSLGLFNTYWGLIFALLIFyiPTAALLMSIFIPVLPKYLIEAARIDGASDWT 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 185 TFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVF 264
Cdd:NF040932 177 IFWKVVLPLTVPGFISTLIFIFIESWNNFFIPLVLTTTPSMRLIPVAVRSYTGGYGTLYNESFAAAVIASIVPLLIFIFL 256


                 ....*...
gi 447114864 265 QKSFTQGI 272
Cdd:NF040932 257 GRYFIRGL 264
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
75-272 7.96e-26

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 102.89  E-value: 7.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  75 MWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWP 154
Cdd:PRK10973  77 LLNSFVMAFSITVGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 155 FGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVAT 234
Cdd:PRK10973 157 TATFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKG 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 447114864 235 MQA--EMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGI 272
Cdd:PRK10973 237 MIAtgEGTTEWNQVMAAMLLTLIPPVVIVLAMQRAFVRGL 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-258 2.11e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  75 MWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMG-----IHDTLWAVILP 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgilPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 150 LIGW-PFGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTI 228
Cdd:cd06261   81 LLLIaPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 447114864 229 SLGVATMQAEMATNYGLIMAGAALAAVPIV 258
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 93-264 5.37e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 68.48  E-value: 5.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864   93 SSLAGYVLAKKR-FYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGW--PFGVFLMKQFSENIPT 169
Cdd:pfam00528   1 GIPLGIIAALRRgRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGwaGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  170 ELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSrqnltISLGVATMQAEMATNYGLIMAG 249
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW-----PGLGLLLIEAILGYDYPEIQGP 155

                         170
                  ....*....|....*
gi 447114864  250 AALAAVPIVTVFLVF 264
Cdd:pfam00528 156 VLAAALILLLLNLLV 170
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 60-213 3.94e-04

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 41.59  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864   60 ENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGI 139
Cdd:TIGR03262  41 ANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  140 HDTL---------WAVILPLIGWPFGVFLMKQFS--ENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFIN 208
Cdd:TIGR03262 121 LKGLlggfsiygfWGIVIGEVFYTFPHALMILVTalSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTL 200


                  ....*
gi 447114864  209 TWNDY 213
Cdd:TIGR03262 201 VITDF 205
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 30-279 7.94e-94

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 278.13  E-value: 7.94e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  30 PFYWILTGAFKSQPDTIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQR 109
Cdd:COG0395   31 PLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLAAYALARFRFRGRK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 110 ILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLI--GWPFGVFLMKQFSENIPTELLESAKIDGCGEIRTFW 187
Cdd:COG0395  111 LLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLafGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFW 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 188 SVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKS 267
Cdd:COG0395  191 RIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGTDWGLLMAAAVIATLPVLILFLFLQRY 270

                        250
                 ....*....|..
gi 447114864 268 FTQGITMGAVKG 279
Cdd:COG0395  271 FVRGLTAGAVKG 282
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 30-279 5.20e-57

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 184.20  E-value: 5.20e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  30 PFYWILTGAFKsqPDTIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQR 109
Cdd:COG3833   32 PILWVVSASFN--PGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLIVAVVTAIISVFLAALAAYAFSRFRFKGRK 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 110 ILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIG--WPFGVFLMKQFSENIPTELLESAKIDGCGEIRTFW 187
Cdd:COG3833  110 AGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGgaIPFNTWLMKGYFDTIPKELDEAAKIDGASHFQIFF 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 188 SVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVATMQA-EMATNYGLIMAGAALAAVPIVTVFLVFQK 266
Cdd:COG3833  190 RIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSdQRNTNWGVFAAGAVLVAIPIVILFLFLQR 269

                        250
                 ....*....|...
gi 447114864 267 SFTQGITMGAVKG 279
Cdd:COG3833  270 YLVSGLTAGGVKG 282
ABC_arch_GlcU NF040932
glucose ABC transporter permease GlcU;
30-272 2.27e-33

glucose ABC transporter permease GlcU;


Pssm-ID: 468865  Cd Length: 272  Bit Score: 122.81  E-value: 2.27e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  30 PFYWILTGAFKSQPDTIVIPPQWFPKMPTMENFQQlmVQNPALQWMWNSVFISLVTMFLVCATSSLAGY---VLAKKRFY 106
Cdd:NF040932  19 PLYAMVINGLKSNFEVLSTPVLVPPSKPTLSAYYT--VWSGLAPPLINSLIVVIPVALISTFLGAMGAYffyRLSERHSI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 107 GQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGW--PFGVFLMKQFSENIPTELLESAKIDGCGEIR 184
Cdd:NF040932  97 LSDFLFSLIALATFIPYQATLVPLTRLEVSLGLFNTYWGLIFALLIFyiPTAALLMSIFIPVLPKYLIEAARIDGASDWT 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 185 TFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVF 264
Cdd:NF040932 177 IFWKVVLPLTVPGFISTLIFIFIESWNNFFIPLVLTTTPSMRLIPVAVRSYTGGYGTLYNESFAAAVIASIVPLLIFIFL 256


                 ....*...
gi 447114864 265 QKSFTQGI 272
Cdd:NF040932 257 GRYFIRGL 264
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
75-272 7.96e-26

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 102.89  E-value: 7.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  75 MWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWP 154
Cdd:PRK10973  77 LLNSFVMAFSITVGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 155 FGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTISLGVAT 234
Cdd:PRK10973 157 TATFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKG 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 447114864 235 MQA--EMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGI 272
Cdd:PRK10973 237 MIAtgEGTTEWNQVMAAMLLTLIPPVVIVLAMQRAFVRGL 276
malG PRK10998
maltose ABC transporter permease MalG;
70-279 9.07e-22

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 92.08  E-value: 9.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  70 PALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQR-ILFAIFIAAMaLPKQVVLVPLVRIVNFMGIH------DT 142
Cdd:PRK10998  80 PVLLWLWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKAtLLKGMLIFQM-FPAVLSLVALYALFDRLGQYipfiglNT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 143 LWAVILP-LIGWPFGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLT 221
Cdd:PRK10998 159 HGGVIFAyLGGIALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLR 238

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447114864 222 SRQNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGAVKG 279
Cdd:PRK10998 239 DVNSYTLAVGMQQYLNPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 50-263 6.77e-18

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 80.93  E-value: 6.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  50 PQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVP 129
Cdd:COG1177   38 LTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 130 LVRIVNFMGIHDTLWAVILPLIGW--PFGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFI 207
Cdd:COG1177  118 LLLLFSALGLSGGLWGLILAHVVFtlPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFT 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447114864 208 NTWNDYFMQLvMLTSRQNLTISLGVATMqaemaTNYGLIMAGAALAAVPIVTVFLV 263
Cdd:COG1177  198 LSFDEFVITL-FLAGPGVTTLPVYIYSM-----IRRGISPEINALSTLLILLSLLL 247
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-258 2.11e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  75 MWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMG-----IHDTLWAVILP 149
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgilPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 150 LIGW-PFGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRQNLTI 228
Cdd:cd06261   81 LLLIaPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 447114864 229 SLGVATMQAEMATNYGLIMAGAALAAVPIV 258
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 93-264 5.37e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 68.48  E-value: 5.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864   93 SSLAGYVLAKKR-FYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGW--PFGVFLMKQFSENIPT 169
Cdd:pfam00528   1 GIPLGIIAALRRgRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGwaGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  170 ELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSrqnltISLGVATMQAEMATNYGLIMAG 249
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW-----PGLGLLLIEAILGYDYPEIQGP 155

                         170
                  ....*....|....*
gi 447114864  250 AALAAVPIVTVFLVF 264
Cdd:pfam00528 156 VLAAALILLLLNLLV 170
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
52-264 4.88e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 65.57  E-value: 4.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  52 WFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVV----L 127
Cdd:COG1178  317 ALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVLglglL 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 128 VPLVRIVNFmGIHDTLWAVILP--LIGWPFGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFT 205
Cdd:COG1178  397 LLFNRPLPL-LLYGTLAILVLAyvVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLV 475

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447114864 206 FINTWNDYfmQLVMLTSRQNlTISLGVATMQaemATNYGLIMAGAALAAVPIVTVFLVF 264
Cdd:COG1178  476 FVTSMKEL--SATLLLRPPG-FETLAVLIYQ---LASSGRYGEAAALALLLVLVSLLPV 528
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 30-263 2.15e-10

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 59.78  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  30 PFYWILTGAFKSQPDTIVIPPQWfpkmpTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQR 109
Cdd:COG1176   29 PLLLLLVYSFTTRDPYGGVVPGF-----TLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGYPIAYFLARAPPRWRN 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 110 ILFAIFIAAMALPkqvVLV-------------PLVRIVNFMGIHD-------TLWAVILPL--IGWPFGVFLMKQFSENI 167
Cdd:COG1176  104 LLLLLVILPFWTS---FLVrtyawivllgrngLLNSLLLALGLIDeplrllyTEFAVVIGLvyVYLPFMVLPLYAALEKI 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 168 PTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLvMLTSRQNLTISLgVATMQAEMATNYGLim 247
Cdd:COG1176  181 DPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPA-LLGGGKVLMIGN-LIYQQFLSALNWPL-- 256

                        250
                 ....*....|....*.
gi 447114864 248 aGAALAAVPIVTVFLV 263
Cdd:COG1176  257 -AAALAVVLLLIVLLV 271
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
60-222 7.53e-09

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 55.53  E-value: 7.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  60 ENFQQLMvQNPALqwmWNSVFISLVTMFLVCATSSLAGYVLA---KKRFYGQRILFAIFIAAMALPKQVVLV-------- 128
Cdd:COG1175   63 DNYARLF-TDPRF---WNALGNTLLFTVVSVPLQLVLGLLLAlllNRKLRGRGFFRTLFFLPWVISPVVVALiwkwlfnp 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864 129 ---PLVRIVNFMGIHDT---------LWAVILPLI--GWPFGVFLmkqFS---ENIPTELLESAKIDGCGEIRTFWSVAF 191
Cdd:COG1175  139 dygLLNALLGALGLEPInwlgdpslaLPAVIIVTVwkGTGFNMLI---FLaglQSIPRELYEAARIDGASPWQRFRRITL 215

                        170       180       190
                 ....*....|....*....|....*....|.
gi 447114864 192 PIVKPGFAALAIFTFINTWNdYFMQLVMLTS 222
Cdd:COG1175  216 PLLRPTILFVLVLSTIGALQ-VFDLVYVLTG 245
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
76-213 1.08e-08

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 55.55  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  76 WNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGW-- 153
Cdd:COG1178   57 GNTLLLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNGLLNTLLRALFGLEPPdi 136

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447114864 154 ---------------PFGVFLMKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDY 213
Cdd:COG1178  137 yglggiilvlvlfnyPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADF 211
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 60-213 3.94e-04

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 41.59  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864   60 ENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGI 139
Cdd:TIGR03262  41 ANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  140 HDTL---------WAVILPLIGWPFGVFLMKQFS--ENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFIN 208
Cdd:TIGR03262 121 LKGLlggfsiygfWGIVIGEVFYTFPHALMILVTalSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTL 200


                  ....*
gi 447114864  209 TWNDY 213
Cdd:TIGR03262 201 VITDF 205
cysT CHL00187
sulfate transport protein; Provisional
 94-206 2.53e-03

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 38.46  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447114864  94 SLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLV----------RIVNFMGIHD--TLWAVILPLI--GWPFGVFL 159
Cdd:CHL00187  76 LLIAWVLVRYNFPGKRLLDAAVDLPFALPTSVAGLTLAtvygdngwigHLLSHLGIQIvfTKLGVLLAMIfvSFPFVVRT 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 447114864 160 MKQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTF 206
Cdd:CHL00187 156 IQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALLTGLALTF 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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