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Conserved domains on  [gi|447131546|ref|WP_001208802|]
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MULTISPECIES: type II secretion system F family protein [Enterobacteriaceae]

Protein Classification

type II secretion system F family protein( domain architecture ID 13630622)

type II secretion system (T2SS) F family protein may play a role in nonspecific adherence to surfaces

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PulF super family cl34272
Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, ...
 96-287 3.10e-08

Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


The actual alignment was detected with superfamily member COG1459:

Pssm-ID: 441068 [Multi-domain]  Cd Length: 399  Bit Score: 54.73  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546  96 AVISAGIRSGSIVDALQFATTLTDAKKQLHQAIWQMAIYPVGLLIMMTGTLYVLNTELIPVLSKISSpdswsgALG---- 171
Cdd:COG1459  129 NMVRAGEASGNLDEVLERLADYLEKQEELRKKIKSALIYPAIVLVVAIGVVLFLLTFVVPQFAGIFE------SFGaelp 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546 172 ----FLYGLSLFVDNYGAICAVLFAVVTGVISWSLKNWKSRSLADNI---MPW--SIYKDIQGAAFLLNMAALLKAKMTT 242
Cdd:COG1459  203 lltrILIALSDFLQNYWWLLLLGLVLLVVGFRRLLRTPKGRLRLDRLllkLPVigPLIRKAALARFARTLATLLSSGVPL 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 447131546 243 LNSLNVLQDFAS-PWLSTRLDSIIYRVRQGDHLGLALRQCGYqFPS 287
Cdd:COG1459  283 LEALEIAAEVVGnRVLREALEEARERVREGESLSEALEASGL-FPP 327
T2SSF pfam00482
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
 27-149 7.33e-05

Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).


:

Pssm-ID: 425708 [Multi-domain]  Cd Length: 119  Bit Score: 41.94  E-value: 7.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546   27 FYEALRFLLENKQPLKTALEQMRDawtdfGRKWHPFAELATDCIESLRE-NSGENSLEYTLGLWVPQEEAAVISAGIRSG 105
Cdd:pfam00482   1 FLRQLATLLRAGLPLVEALEILAE-----EAENGPLREELRRIAERVREgGSLSEALARTPSSVFPPLLVALIAAGESGG 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 447131546  106 SIVDALQFATTLTDAKKQLHQAIWQMAIYPVGLLIMMTGTLYVL 149
Cdd:pfam00482  76 NLAEVLERLADYLEEERELRRKIKAALLYPLILLVVALLVLLIL 119
 
Name Accession Description Interval E-value
PulF COG1459
Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, ...
 96-287 3.10e-08

Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441068 [Multi-domain]  Cd Length: 399  Bit Score: 54.73  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546  96 AVISAGIRSGSIVDALQFATTLTDAKKQLHQAIWQMAIYPVGLLIMMTGTLYVLNTELIPVLSKISSpdswsgALG---- 171
Cdd:COG1459  129 NMVRAGEASGNLDEVLERLADYLEKQEELRKKIKSALIYPAIVLVVAIGVVLFLLTFVVPQFAGIFE------SFGaelp 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546 172 ----FLYGLSLFVDNYGAICAVLFAVVTGVISWSLKNWKSRSLADNI---MPW--SIYKDIQGAAFLLNMAALLKAKMTT 242
Cdd:COG1459  203 lltrILIALSDFLQNYWWLLLLGLVLLVVGFRRLLRTPKGRLRLDRLllkLPVigPLIRKAALARFARTLATLLSSGVPL 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 447131546 243 LNSLNVLQDFAS-PWLSTRLDSIIYRVRQGDHLGLALRQCGYqFPS 287
Cdd:COG1459  283 LEALEIAAEVVGnRVLREALEEARERVREGESLSEALEASGL-FPP 327
T2SSF pfam00482
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
 228-335 4.70e-05

Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).


Pssm-ID: 425708 [Multi-domain]  Cd Length: 119  Bit Score: 42.32  E-value: 4.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546  228 FLLNMAALLKAKMTTLNSLNVLQDFAS-PWLSTRLDSIIYRVRQGDHLGLALRQCGYQFPSREAANFLSLL-QGDGATEL 305
Cdd:pfam00482   1 FLRQLATLLRAGLPLVEALEILAEEAEnGPLREELRRIAERVREGGSLSEALARTPSSVFPPLLVALIAAGeSGGNLAEV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 447131546  306 IGNYGQRWLVQTLERVKKRAAVVRLIMLIF 335
Cdd:pfam00482  81 LERLADYLEEERELRRKIKAALLYPLILLV 110
T2SSF pfam00482
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
 27-149 7.33e-05

Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).


Pssm-ID: 425708 [Multi-domain]  Cd Length: 119  Bit Score: 41.94  E-value: 7.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546   27 FYEALRFLLENKQPLKTALEQMRDawtdfGRKWHPFAELATDCIESLRE-NSGENSLEYTLGLWVPQEEAAVISAGIRSG 105
Cdd:pfam00482   1 FLRQLATLLRAGLPLVEALEILAE-----EAENGPLREELRRIAERVREgGSLSEALARTPSSVFPPLLVALIAAGESGG 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 447131546  106 SIVDALQFATTLTDAKKQLHQAIWQMAIYPVGLLIMMTGTLYVL 149
Cdd:pfam00482  76 NLAEVLERLADYLEEERELRRKIKAALLYPLILLVVALLVLLIL 119
GspF TIGR02120
type II secretion system protein F; This membrane protein is a component of the terminal ...
 96-286 1.45e-03

type II secretion system protein F; This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273980 [Multi-domain]  Cd Length: 399  Bit Score: 40.39  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546   96 AVISAGIRSGSIVDALQFATTLTDAKKQLHQAIWQMAIYPVgllIMMTGTLYVLNTELIPVLSKISSPDSWSGA-----L 170
Cdd:TIGR02120 130 ALVAAGEASGALDAVLERLADYLEERQALRSKITTALIYPA---VLTVVAIGVVIFLLAYVVPKVVEQFAHMKQtlpllT 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546  171 GFLYGLSLFVDNYGAICAVLFAVVTGVISWSLK--NWK---SRSLADNIMPWSIYKDIQGAAFLLNMAALLKAKMTTLNS 245
Cdd:TIGR02120 207 RALIALSDFLRSWGWALLAALAALVVLFRRLLRdpAFRlrfDRRLLRLPVIGRLVRGLNTARFARTLSILLSSGVPLLRA 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 447131546  246 LNVL-QDFASPWLSTRLDSIIYRVRQGDHLGLALRQCGyQFP 286
Cdd:TIGR02120 287 LQIArETLTNRALRAAVEDAAARVREGGSLSRALRATG-LFP 327
 
Name Accession Description Interval E-value
PulF COG1459
Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, ...
 96-287 3.10e-08

Type II secretory pathway, component PulF [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441068 [Multi-domain]  Cd Length: 399  Bit Score: 54.73  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546  96 AVISAGIRSGSIVDALQFATTLTDAKKQLHQAIWQMAIYPVGLLIMMTGTLYVLNTELIPVLSKISSpdswsgALG---- 171
Cdd:COG1459  129 NMVRAGEASGNLDEVLERLADYLEKQEELRKKIKSALIYPAIVLVVAIGVVLFLLTFVVPQFAGIFE------SFGaelp 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546 172 ----FLYGLSLFVDNYGAICAVLFAVVTGVISWSLKNWKSRSLADNI---MPW--SIYKDIQGAAFLLNMAALLKAKMTT 242
Cdd:COG1459  203 lltrILIALSDFLQNYWWLLLLGLVLLVVGFRRLLRTPKGRLRLDRLllkLPVigPLIRKAALARFARTLATLLSSGVPL 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 447131546 243 LNSLNVLQDFAS-PWLSTRLDSIIYRVRQGDHLGLALRQCGYqFPS 287
Cdd:COG1459  283 LEALEIAAEVVGnRVLREALEEARERVREGESLSEALEASGL-FPP 327
T2SSF pfam00482
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
 228-335 4.70e-05

Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).


Pssm-ID: 425708 [Multi-domain]  Cd Length: 119  Bit Score: 42.32  E-value: 4.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546  228 FLLNMAALLKAKMTTLNSLNVLQDFAS-PWLSTRLDSIIYRVRQGDHLGLALRQCGYQFPSREAANFLSLL-QGDGATEL 305
Cdd:pfam00482   1 FLRQLATLLRAGLPLVEALEILAEEAEnGPLREELRRIAERVREGGSLSEALARTPSSVFPPLLVALIAAGeSGGNLAEV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 447131546  306 IGNYGQRWLVQTLERVKKRAAVVRLIMLIF 335
Cdd:pfam00482  81 LERLADYLEEERELRRKIKAALLYPLILLV 110
T2SSF pfam00482
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
 27-149 7.33e-05

Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).


Pssm-ID: 425708 [Multi-domain]  Cd Length: 119  Bit Score: 41.94  E-value: 7.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546   27 FYEALRFLLENKQPLKTALEQMRDawtdfGRKWHPFAELATDCIESLRE-NSGENSLEYTLGLWVPQEEAAVISAGIRSG 105
Cdd:pfam00482   1 FLRQLATLLRAGLPLVEALEILAE-----EAENGPLREELRRIAERVREgGSLSEALARTPSSVFPPLLVALIAAGESGG 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 447131546  106 SIVDALQFATTLTDAKKQLHQAIWQMAIYPVGLLIMMTGTLYVL 149
Cdd:pfam00482  76 NLAEVLERLADYLEEERELRRKIKAALLYPLILLVVALLVLLIL 119
GspF TIGR02120
type II secretion system protein F; This membrane protein is a component of the terminal ...
 96-286 1.45e-03

type II secretion system protein F; This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273980 [Multi-domain]  Cd Length: 399  Bit Score: 40.39  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546   96 AVISAGIRSGSIVDALQFATTLTDAKKQLHQAIWQMAIYPVgllIMMTGTLYVLNTELIPVLSKISSPDSWSGA-----L 170
Cdd:TIGR02120 130 ALVAAGEASGALDAVLERLADYLEERQALRSKITTALIYPA---VLTVVAIGVVIFLLAYVVPKVVEQFAHMKQtlpllT 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447131546  171 GFLYGLSLFVDNYGAICAVLFAVVTGVISWSLK--NWK---SRSLADNIMPWSIYKDIQGAAFLLNMAALLKAKMTTLNS 245
Cdd:TIGR02120 207 RALIALSDFLRSWGWALLAALAALVVLFRRLLRdpAFRlrfDRRLLRLPVIGRLVRGLNTARFARTLSILLSSGVPLLRA 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 447131546  246 LNVL-QDFASPWLSTRLDSIIYRVRQGDHLGLALRQCGyQFP 286
Cdd:TIGR02120 287 LQIArETLTNRALRAAVEDAAARVREGGSLSRALRATG-LFP 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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