|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
4-458 |
0e+00 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 821.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 4 MQRSKDSLAKWLSAILPVVIVGLVGLFAVTVIRDYGRETAAARQTLLEKGSVLIRALESGSRVGMGMRMHHAQQQALLEE 83
Cdd:PRK10364 1 MQRSKDSLAKWLSALLPVVIVGLVGLFSVTVIRDYGRETAAARQTLLEKGSVLIRALESGSRVGMGMRMHHAQQQALLEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 84 MAGQPGVRWFAVTDEQGTIVMHSNSGMMGKQLYSPQEMQQLHPGDEEAWRRIDSADGEPVLEIYRQFQPMFAAGMHRMRH 163
Cdd:PRK10364 81 MAGQPGVRWFAVTDEQGTIVAHSNPGMVGKQLYSPQEMQQLHPGDEEAWRRIDSADGEPVLEIYRQFQPMFAAGMHGMRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 164 MQQY--AATPQAIFIAFDASNIVSAEDREQRNTLIILFALATVLLASVLSFFWYRRYLRSRQLLQDEMKRKEKLVALGHL 241
Cdd:PRK10364 161 MQQYaaANTPQAIFIAFDASNLVSAQAREQRNTLIILFALATVLLASLLAFFWYRRYLRSRQLLQDEMKRKEKLVALGHL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 242 AAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVELNTLINHSLQLV 321
Cdd:PRK10364 241 AAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHSLQLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 322 SQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 401
Cdd:PRK10364 321 SQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 447134643 402 FTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRKDPQG 458
Cdd:PRK10364 401 FTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDPQG 457
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
222-450 |
1.16e-85 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 266.71 E-value: 1.16e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 222 RQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGgEAHQLAQVMAKEADRLNRVVSELLELVKPT 301
Cdd:COG3852 119 RKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELPDD-ELREYTQLIIEEADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 302 HLALQAVELNTLINHSLQLVSQDANSReIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTAS----- 376
Cdd:COG3852 198 PPEREPVNLHEVLERVLELLRAEAPKN-IRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRverqv 276
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447134643 377 -----ESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 450
Cdd:COG3852 277 tlgglRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
124-449 |
1.45e-80 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 253.57 E-value: 1.45e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 124 LHPGDEEAWRRIDSADGEPVLEIYRQFQPMFAAGMHRMRHMQQYAATPQAIFIAFDASNIVSAEDREQRNTLIILFALAT 203
Cdd:COG4191 38 LLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDIT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 204 VLlasvlsffwyRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKG---LAKYFAERASAGGEAHQLAQVM 280
Cdd:COG4191 118 EL----------ERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGnaeLLRRRLEDEPDPEELREALERI 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 281 AKEADRLNRVVSELLELVKPTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLN 360
Cdd:COG4191 188 LEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLIN 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 361 AIQAI--GQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA--EGTGLGLAVVHNIVEQHGGTIQVASQ 436
Cdd:COG4191 268 AIDAMeeGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESE 347
|
330
....*....|...
gi 447134643 437 EGKGATFTLWLPV 449
Cdd:COG4191 348 PGGGTTFTITLPL 360
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
224-449 |
1.00e-78 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 250.65 E-value: 1.00e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 224 LLQD--EMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEA-----HQLAQVMAKEADRLNRVVSELLE 296
Cdd:COG5000 185 VFDDitELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEdredlERALDTIIRQVDRLKRIVDEFLD 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 297 LVKPTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTAS 376
Cdd:COG5000 265 FARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTR 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447134643 377 ESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:COG5000 345 REDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
220-451 |
2.95e-74 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 244.49 E-value: 2.95e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 220 RSRqlLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAqVMAKEADRLNRVVSELLELVK 299
Cdd:PRK11360 374 RKR--LQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLS-VVLREVDRLNKVIDQLLEFSR 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 300 PTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESG 379
Cdd:PRK11360 451 PRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYS 530
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447134643 380 AG-VKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNI 451
Cdd:PRK11360 531 DGqVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
225-449 |
3.46e-69 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 227.94 E-value: 3.46e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 225 LQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFaeRASAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLA 304
Cdd:COG5809 257 LEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLL--KDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIK 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 305 LQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISV-TASESGAGVK 383
Cdd:COG5809 335 YEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIeTKAEDDDKVV 414
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447134643 384 ISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:COG5809 415 ISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
143-450 |
3.41e-67 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 217.85 E-value: 3.41e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 143 VLEIYRQFQPMFAAGMHRMRHMQQYAATPQAIFIAFDASNIVSAEDREQRNTLIILFALATVLLASVLSFFWYRRYLRSR 222
Cdd:COG0642 15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 223 QLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAggEAHQLAQVMAKEADRLNRVVSELLELVK--- 299
Cdd:COG0642 95 LLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDE--EQREYLETILRSADRLLRLINDLLDLSRlea 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 300 -PTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASES 378
Cdd:COG0642 173 gKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447134643 379 GAGVKISVTDSGKGIAADQLEAIFTPYFTTKA----EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 450
Cdd:COG0642 253 GDRVRISVEDTGPGIPPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
217-449 |
1.18e-65 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 215.03 E-value: 1.18e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 217 RYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKyFAERASAGGEAHQLAQVMAKEADRLNRVVSELLE 296
Cdd:COG5807 126 RDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQ-LLQESREDSEREEYFNIIISEIDRINTIITELLV 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 297 LVKPTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTAS 376
Cdd:COG5807 205 LSKPKKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTY 284
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447134643 377 ESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:COG5807 285 VEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
114-450 |
3.71e-63 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 209.41 E-value: 3.71e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 114 QLYSPQEMQQLHPGDEEAWRRIDSADGEPVLEIYRQFQPMFAAGMHRMRHMQQYAATPQAIFIAFDASNIVSAEDREQRN 193
Cdd:COG5002 43 LLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 194 TLIILFALATVLLASVLSFFWYRRYLRSRQLLQDEMKRKEKLvaLGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEA 273
Cdd:COG5002 123 ELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQM--RREFVANVSHELRTPLTSIRGYLELLLDGAADDPEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 274 HQ-LAQVMAKEADRLNRVVSELLELVK----PTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPD 348
Cdd:COG5002 201 RReYLEIILEEAERLSRLVNDLLDLSRlesgELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPD 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 349 RLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTT------KAEGTGLGLAVVHN 422
Cdd:COG5002 281 RLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVdksrsrETGGTGLGLAIVKH 360
|
330 340
....*....|....*....|....*...
gi 447134643 423 IVEQHGGTIQVASQEGKGATFTLWLPVN 450
Cdd:COG5002 361 IVEAHGGRIWVESEPGKGTTFTITLPLA 388
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
194-449 |
4.30e-63 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 209.72 E-value: 4.30e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 194 TLIILFALATVLLASVLSFfwyrryLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEA 273
Cdd:COG5806 163 YFIIIQLLAMLIAVYLIEN------LIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKR 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 274 HQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQV 353
Cdd:COG5806 237 KQYIRIALEELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGL-YIEGDRQKLQQC 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 354 LLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQV 433
Cdd:COG5806 316 LINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRV 395
|
250
....*....|....*.
gi 447134643 434 ASQEGKGATFTLWLPV 449
Cdd:COG5806 396 ESEVGKGTTFTITLPL 411
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
208-449 |
6.46e-63 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 211.51 E-value: 6.46e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 208 SVLSFFWYRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASaggEAHQLAQVMAKEADRL 287
Cdd:COG5805 257 SVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIE---DKEEYFDIMLSELDRI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 288 NRVVSELLELVKPTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQ 367
Cdd:COG5805 334 ESIISEFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPN 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 368 HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWL 447
Cdd:COG5805 414 GGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
|
..
gi 447134643 448 PV 449
Cdd:COG5805 494 PL 495
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
225-449 |
2.71e-62 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 202.06 E-value: 2.71e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 225 LQDEMKRKEKLVAL-GHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQ-LAQVMAKEADRLNRVVSELLELVK--- 299
Cdd:COG2205 2 LEEALEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERReLLEIIRESAERLLRLIEDLLDLSRles 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 300 -PTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASES 378
Cdd:COG2205 82 gKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447134643 379 GAGVKISVTDSGKGIAADQLEAIFTPYF----TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
134-449 |
1.00e-58 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 199.59 E-value: 1.00e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 134 RIDSADGEPVLEIYRQFQPMFAAGMHRmrHMQQYAATPQAIFIAFDASNIVSAEDREQRNTLIILFALATVLLASVLSFF 213
Cdd:COG5808 138 LINILDPDKYIEIVDQNGQSVFTSGHR--EESKSVSNKLDKVPWEVEVYPNPVTNDELGQALAIRKLIILVLISIIFLLL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 214 WYRRYLRSRQL---LQDEMKRKEKLValGHLAAGVAHEIRNPLSSIKGLAKYFAERAsAGGEAHQLAQVMAKEADRLNRV 290
Cdd:COG5808 216 QYNLLKRKTLLervIQEINTQKLELI--GTFAASTAHEIRNPLTSIKGFIQLLQEKY-PELEDQKYFDIIQEEIQRINQI 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 291 VSELLELVKPTHLALQAVELNTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGV 370
Cdd:COG5808 293 VSEFLVLGKPTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGK 372
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447134643 371 ISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:COG5808 373 LTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPL 451
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
11-452 |
3.67e-44 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 161.49 E-value: 3.67e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 11 LAKWLSAILPVVIVGLVGLFAVTVIRDYGRETAAARQTLLEKGSVLIRALESGSRVGMGMRMHHAQQQALLEEMAGQPGV 90
Cdd:COG4251 66 LLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 91 RWFAVTDEQGTIVMHSNSGMMGKQLYSPQEMQQLHPGDEEAWRRIDSADGEPVLEIYRQFQPMFAAGMHRMRHMQQYAAT 170
Cdd:COG4251 146 ALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 171 PQAIFIAFDASNIVSAEDREQRNTLIILFALATVLLasvlsffwyRRYLRSRQLLQDEMKRKEKlvALGHLAAGVAHEIR 250
Cdd:COG4251 226 GLLLLLLLLLVLLLLLILLLLLLILVLELLELRLEL---------EELEEELEERTAELERSNE--ELEQFAYVASHDLR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 251 NPLSSIKGLAKYFAERASA--GGEAHQLAQVMAKEADRLNRVVSELLEL--VKPTHLALQAVELNTLINHSLQLVSQDAN 326
Cdd:COG4251 295 EPLRKISGFSQLLEEDYGDklDEEGREYLERIRDAAERMQALIDDLLAYsrVGRQELEFEPVDLNELLEEVLEDLEPRIE 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 327 SREIQLRFtanDTLPEIQADPDRLTQVLLNLYLNAI--QAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTP 404
Cdd:COG4251 375 ERGAEIEV---GPLPTVRGDPTLLRQVFQNLISNAIkySRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEI 451
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 447134643 405 YFT----TKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 452
Cdd:COG4251 452 FQRlhsrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
216-449 |
5.82e-38 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 147.13 E-value: 5.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 216 RRYLRS-RQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSEL 294
Cdd:PRK13837 427 RRRLETeRDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQI 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 295 LELVKPTHLALQAVELNTLINHSLQLVSQDANSR-EIQLRFTANDTLpeIQADPDRLTQVLLNLYLNAIQAIGQHGVISV 373
Cdd:PRK13837 507 LAFGRKGERNTKPFDLSELVTEIAPLLRVSLPPGvELDFDQDQEPAV--VEGNPAELQQVLMNLCSNAAQAMDGAGRVDI 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 374 TASES---------------GAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEG 438
Cdd:PRK13837 585 SLSRAklrapkvlshgvlppGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVG 664
|
250
....*....|.
gi 447134643 439 KGATFTLWLPV 449
Cdd:PRK13837 665 RGTRFDVYLPP 675
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
345-449 |
1.32e-37 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 132.77 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 345 ADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA-----EGTGLGLAV 419
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrkiGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 447134643 420 VHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-449 |
1.84e-36 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 129.85 E-value: 1.84e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 347 PDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIV 424
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRII 80
|
90 100
....*....|....*....|....*
gi 447134643 425 EQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
246-450 |
4.57e-34 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 131.51 E-value: 4.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 246 AHEIRNPLSSIKGLAKyfaerasaGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLAlqAVeLNTLINhslqlvsqDA 325
Cdd:COG3290 197 RHDFRNHLHTISGLLQ--------LGEYDEALEYIDEISEELQELIDSLLSRIGNPVLA--AL-LLGKAA--------RA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 326 NSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAI----GQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 401
Cdd:COG3290 258 RERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKI 337
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 447134643 402 FTPYFTTKA-EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 450
Cdd:COG3290 338 FERGFSTKLgEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
350-447 |
1.51e-33 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 121.94 E-value: 1.51e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK----AEGTGLGLAVVHNIVE 425
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 447134643 426 QHGGTIQVASQEGKGATFTLWL 447
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
345-451 |
1.65e-32 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 119.40 E-value: 1.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 345 ADPDRLTQVLLNLYLNAIQAIGQHGVISVTASEsGAGVKISVTDSGKGIAADQLEAIFTPYFT---TKAEGTGLGLAVVH 421
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 447134643 422 NIVEQHGGTIQVASQEGKGATFTLWLPVNI 451
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
2.86e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 107.48 E-value: 2.86e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAIGQHGV------ISVTASESGAgVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNI 423
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreltIRTSPADDRA-VTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSI 79
|
90 100
....*....|....*....|....*
gi 447134643 424 VEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16920 80 IEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
225-449 |
8.38e-28 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 113.89 E-value: 8.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 225 LQDEMKRKEKLVALghlaagVAHEIRNPLS-------SIKGLAKYFAERASAGGEAhQLAQVMAKEADRLNRVVSELLEL 297
Cdd:PRK09303 144 LLEQLKFKDRVLAM------LAHDLRTPLTaaslaleTLELGQIDEDTELKPALIE-QLQDQARRQLEEIERLITDLLEV 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 298 VKP--THLALQAVELNtlinhsLQLVSQDANSrEIQLRFTANDT---------LPEIQADPDRLTQVLLNLYLNAIQAIG 366
Cdd:PRK09303 217 GRTrwEALRFNPQKLD------LGSLCQEVIL-ELEKRWLAKSLeiqtdipsdLPSVYADQERIRQVLLNLLDNAIKYTP 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 367 QHGVISVTA-SESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK----AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGA 441
Cdd:PRK09303 290 EGGTITLSMlHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPrdegTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGS 369
|
....*...
gi 447134643 442 TFTLWLPV 449
Cdd:PRK09303 370 CFHFTLPV 377
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
222-449 |
1.01e-27 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 112.87 E-value: 1.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 222 RQLLQdEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFaERASAGGEAHQLAQVMAKEADRLNRVVSELLelvKPT 301
Cdd:PRK11073 115 RRLSQ-EQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLL-SKALPDPALTEYTKVIIEQADRLRNLVDRLL---GPQ 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 302 HLALQAVE-LNTLINHSLQLVSQDAnSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQ-HGVISV---TAS 376
Cdd:PRK11073 190 RPGTHVTEsIHKVAERVVQLVSLEL-PDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPeGGTITLrtrTAF 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 377 ESGA-------GVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKgATFTLWLPV 449
Cdd:PRK11073 269 QLTLhgeryrlAARIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
246-449 |
4.86e-27 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 113.02 E-value: 4.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 246 AHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAkEADRLNRVVSELLELVK----PTHLALQAVELNTLINHSLQLV 321
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPEDRARFTGNILT-QSARLQQLIDRLLELARleqrQELEVLEPVALAALLEELVEAR 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 322 SQDANSREIQLRFTANDTlpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 401
Cdd:PRK11100 343 EAQAAAKGITLRLRPDDA--RVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRI 420
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 447134643 402 F-----TPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:PRK11100 421 FerfysLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
222-449 |
8.00e-27 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 113.23 E-value: 8.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 222 RQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGgeaHQLAQVMAKEADRLNRVVS-------EL 294
Cdd:PRK13557 147 RRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHP---DADRGRMARSVENIRAAAEraatltqQL 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 295 LELVKPTHLALQAVELNTLINHSLQLVSQdANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISV- 373
Cdd:PRK13557 224 LAFARKQRLEGRVLNLNGLVSGMGELAER-TLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIr 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 374 TASE--------------SGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE--GTGLGLAVVHNIVEQHGGTIQVASQE 437
Cdd:PRK13557 303 TRNVeiededlamyhglpPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEgkGTGLGLSMVYGFAKQSGGAVRIYSEV 382
|
250
....*....|..
gi 447134643 438 GKGATFTLWLPV 449
Cdd:PRK13557 383 GEGTTVRLYFPA 394
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-447 |
4.10e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 101.76 E-value: 4.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAIG--QHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVE 425
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|..
gi 447134643 426 QHGGTIQVASQEGKGATFTLWL 447
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTFDL 102
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
226-448 |
1.02e-24 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 107.08 E-value: 1.02e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 226 QDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKgLAKYFAERASAGGEAHQLAQV---MAKEADRLNRVVSELLELVKPTH 302
Cdd:COG4192 421 QDELIQAAKMAVVGQTMTSLAHELNQPLNAMS-MYLFSAKKALEQENYAQLPTSldkIEGLIERMDKIIKSLRQFSRKSD 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 303 LALQAVELNTLINHSLQLVSQDANSREIQLrftandTLPE---IQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESG 379
Cdd:COG4192 500 TPLQPVDLRQVIEQAWELVESRAKPQQITL------HIPDdlmVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNA 573
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447134643 380 AGVKISVTDSGKGIAAdqLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:COG4192 574 ENLRVAISDNGNGWPL--VDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
350-449 |
1.88e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 97.18 E-value: 1.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQaIGQHGVISVTAS-----ESGAGVKISVTDSGKGIAADQLEAIFTPY------FTTKAEGTGLGLA 418
Cdd:cd16922 1 LRQILLNLLGNAIK-FTEEGEVTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 447134643 419 VVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
350-448 |
3.94e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 93.98 E-value: 3.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAIGQHGVISVTASE---------------SGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEG-- 412
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNqrvdadyalnyrdliPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGkg 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 447134643 413 TGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
238-448 |
7.89e-23 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 100.54 E-value: 7.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 238 LGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTH----LALQAVELNTL 313
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNgqlaLERVRLDLAAE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 314 INHSLQLVSQDANSREIQLRFTANDTLPeiqADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGI 393
Cdd:TIGR01386 321 LAKVAEYFEPLAEERGVRIRVEGEGLVR---GDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGI 397
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447134643 394 AADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKgATFTLWLP 448
Cdd:TIGR01386 398 PPEHLSRLFDRFYrvdparSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
245-457 |
1.68e-21 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 97.70 E-value: 1.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 245 VAHEIRNPLSSIKGLAKYFAErASAGGEAHQLAQVMAKEADRLNRVVSELLELVK----PTHLALQAVELNTLINHSLQL 320
Cdd:PRK11091 290 ISHELRTPLNGIVGLSRILLD-TELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKmerrKLQLDNQPIDFTDFLADLENL 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 321 VSQDANSREIQLRFTANDTLPE-IQADPDRLTQVLLNLYLNAIQaIGQHGVISVTAS-ESGAGVKISVTDSGKGIAADQL 398
Cdd:PRK11091 369 SGLQAEQKGLRFDLEPLLPLPHkVITDGTRLRQILWNLISNAVK-FTQQGGVTVRVRyEEGDMLTFEVEDSGIGIPEDEL 447
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447134643 399 EAIFTPYFTTK-------AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRKDPQ 457
Cdd:PRK11091 448 DKIFAMYYQVKdshggkpATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVE 513
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
240-450 |
2.61e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 97.02 E-value: 2.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 240 HLAAgVAHEIRNPLSSIKGlAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVK----PTHLALQAVELNTLIN 315
Cdd:PRK15347 401 HLTT-ISHEIRTPLNGVLG-ALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRiesgQMTLSLEETALLPLLD 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 316 HSLQLVSQDANSREIQLRFTANDTLP-EIQADPDRLTQVLLNLYLNAIQaIGQHGVISVTASESGAGVKISVTDSGKGIA 394
Cdd:PRK15347 479 QAMLTIQGPAQSKSLTLRTFVGAHVPlYLHLDSLRLRQILVNLLGNAVK-FTETGGIRLRVKRHEQQLCFTVEDTGCGID 557
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 447134643 395 ADQLEAIFTPYFTT--KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 450
Cdd:PRK15347 558 IQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
1.17e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 86.69 E-value: 1.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAI-GQHGVISVTASESGA----------GVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLA 418
Cdd:cd16918 1 LIQVFLNLVRNAAQALaGSGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 447134643 419 VVHNIVEQHGGTIQVASQEGKgATFTLWLP 448
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
241-449 |
2.75e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 92.67 E-value: 2.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 241 LAAGVAHEIRNPLSSIKgLAkyfAERASAGGEahQLAQVMAKEADRLNRVVSELLELVKP-THLALQAVELNTLINHSLQ 319
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIR-LA---TEMMSEEDG--YLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEVIA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 320 LVSQDAnsREIQLRFtaNDTLPEIQADPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIAADQLE 399
Cdd:PRK09467 306 AESGYE--REIETAL--QPGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLK 379
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 447134643 400 AIFTPyFTT--KA---EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:PRK09467 380 HLFQP-FTRgdSArgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
243-457 |
2.96e-20 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 93.82 E-value: 2.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 243 AGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLaQVMAKEADRLNRVVSELLELV------KPTHLALQAVELNTLINH 316
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLLADNPALNAQRDDL-RAITDSGESLLTILNDILDYSaieaggKNVSVSDEPFEPRPLLES 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 317 SLQLVSQDANSREIQLRFTANDTLPE-IQADPDRLTQVLLNLYLNAIQaIGQHGVISVTASESGAGVKISVTDSGKGIAA 395
Cdd:PRK11466 528 TLQLMSGRVKGRPIRLATDIADDLPTaLMGDPRRIRQVITNLLSNALR-FTDEGSIVLRSRTDGEQWLVEVEDSGCGIDP 606
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447134643 396 DQLEAIFTPY--FTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRKDPQ 457
Cdd:PRK11466 607 AKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATAPVP 670
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-448 |
3.44e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 85.28 E-value: 3.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 346 DPDRLTQVLLNLYLNAIQAIGQ------HGVISVTASESGAgVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAV 419
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGrpsdvgEVRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAI 79
|
90 100
....*....|....*....|....*....
gi 447134643 420 VHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16944 80 VKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
5.04e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 84.68 E-value: 5.04e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNI 423
Cdd:cd16949 1 LARALENVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 447134643 424 VEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
241-450 |
1.52e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 91.64 E-value: 1.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 241 LAAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHqLAQVMAKEADRLN--RVVSELLELVKPT----HLALQAVELNTLI 314
Cdd:PRK10490 667 LLAALSHDLRTPLTVLFGQAEILTLDLASEGSPH-ARQASEIRQQVLNttRLVNNLLDMARIQsggfNLRKEWLTLEEVV 745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 315 NHSLQLVSQDANSREIQLRFTANDTLpeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIA 394
Cdd:PRK10490 746 GSALQMLEPGLSGHPINLSLPEPLTL--IHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIP 823
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 395 ADQLEAIFTPYFTTKAE----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 450
Cdd:PRK10490 824 PGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
1.55e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 83.53 E-value: 1.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAI--GQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPY----FTTKAEGTGLGLAVVHNI 423
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrlhSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 447134643 424 VEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-448 |
2.24e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 83.28 E-value: 2.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 346 DPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK------AEGTGLGLAV 419
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVEssrnraSGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 447134643 420 VHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
243-448 |
3.11e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 89.68 E-value: 3.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 243 AGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVKPThlALQAVELNTLIN--HSLQL 320
Cdd:PRK11006 209 ANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIE--AAPTIDLNEKVDvpMMLRV 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 321 VSQDANS---REIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQ 397
Cdd:PRK11006 287 LEREAQTlsqGKHTITFEVDNSL-KVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEH 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 447134643 398 LEAI---FtpYFTTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:PRK11006 366 IPRLterF--YRVDKARsrqtgGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
228-454 |
6.18e-19 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 90.18 E-value: 6.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 228 EMKRKEKL---VALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVKPT--- 301
Cdd:PRK09959 699 EVERNKAInatVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIEsgn 778
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 302 -HLALQAVELNTLINHSLQLVSQDANSREIQLrfTANDTLPE---IQADPDRLTQVLLNLYLNAIQaIGQHGVISVTAS- 376
Cdd:PRK09959 779 yQLQPQWVDIPTLVQNTCHSFGAIAASKSIAL--SCSSTFPDhylVKIDPQAFKQVLSNLLSNALK-FTTEGAVKITTSl 855
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 377 ----ESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA----EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:PRK09959 856 ghidDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAgrqqTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
....*.
gi 447134643 449 VNITRK 454
Cdd:PRK09959 936 VEISQQ 941
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-448 |
7.28e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 81.56 E-value: 7.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 356 NLYLNAIQAIG----QHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGT-GLGLAVVHNIVEQHGGT 430
Cdd:cd16915 7 NLIDNALDALAatgaPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGGS 86
|
90
....*....|....*...
gi 447134643 431 IQVASQEGKGATFTLWLP 448
Cdd:cd16915 87 ITVESEPGGGTTFSIRIP 104
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
245-453 |
2.17e-18 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 87.29 E-value: 2.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 245 VAHEIRNPLSSIKgLAKYFAERASagGEAHQLAQVmAKEADRLNRVVSELLEL----VKpTHLALQAVELNTLINHSLQL 320
Cdd:PRK09470 250 ISHELRTPLTRLQ-LATALLRRRQ--GESKELERI-ETEAQRLDSMINDLLVLsrnqQK-NHLERETFKANSLWSEVLED 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 321 VSQDANSREIQLRFTANdtlPE---IQADPDRLTQVLLNLYLNAIQAIGQHgvISVTASESGAGVKISVTDSGKGIAADQ 397
Cdd:PRK09470 325 AKFEAEQMGKSLTVSAP---PGpwpINGNPNALASALENIVRNALRYSHTK--IEVAFSVDKDGLTITVDDDGPGVPEEE 399
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447134643 398 LEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITR 453
Cdd:PRK09470 400 REQIFRPFYRVdeardrESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
346-448 |
2.80e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 80.23 E-value: 2.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 346 DPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA-GVKISVTDSGKGIAADQLEAIFTPY------FTTKAEGTGLGLA 418
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLnRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 447134643 419 VVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
188-450 |
1.20e-17 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 85.07 E-value: 1.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 188 DREQRNTLIILFALATvLLASVLSFfwyrryLRSRQLLQdEMKR----KEKLVA--------------LGHLA------- 242
Cdd:PRK10549 159 DKQQRRTSWLIVALST-LLAALATF------LLARGLLA-PVKRlvegTHKLAAgdfttrvtptsrdeLGRLAqdfnqla 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 243 --------------AGVAHEIRNPLSSIKGLAkyfaerasaggEAHQ--LAQVMAKEADRLNRVVSELLELVKPTH---- 302
Cdd:PRK10549 231 stlekneqmrrdfmADISHELRTPLAVLRGEL-----------EAIQdgVRKFTPESVASLQAEVGTLTKLVDDLHqlsl 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 303 -----LALQAVELNtlINHSLQLVSqdANSREI----QLRFTANdtLPE---IQADPDRLTQVLLNLYLNAIQAIGQHGV 370
Cdd:PRK10549 300 sdegaLAYRKTPVD--LVPLLEVAG--GAFRERfasrGLTLQLS--LPDsatVFGDPDRLMQLFNNLLENSLRYTDSGGS 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 371 ISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFT 444
Cdd:PRK10549 374 LHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSIT 453
|
....*.
gi 447134643 445 LWLPVN 450
Cdd:PRK10549 454 VELPLE 459
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
244-457 |
2.80e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 83.50 E-value: 2.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 244 GVAHEIRNPLSSIKglakYFAERASAGGEAHQLAqvMAKEADRLNRVVSELL---ELVKP-THLALQAVELNTLIN---H 316
Cdd:PRK10604 218 GIAHELRTPLVRLR----YRLEMSDNLSAAESQA--LNRDIGQLEALIEELLtyaRLDRPqNELHLSEPDLPAWLSthlA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 317 SLQLVSQDansREIQLrftanDTLPEIQ---ADPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGI 393
Cdd:PRK10604 292 DIQAVTPE---KTVRL-----DTPHQGDygaLDMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPGI 361
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 394 AADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRKDPQ 457
Cdd:PRK10604 362 PPEERERVFEPFVRLDPSrdratgGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHNLPQFT 431
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
350-455 |
9.38e-16 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 79.57 E-value: 9.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAIGQ--HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQH 427
Cdd:PRK11086 434 LITILGNLIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENL 513
|
90 100
....*....|....*....|....*...
gi 447134643 428 GGTIQVASQEGKGATFTLWLPVNITRKD 455
Cdd:PRK11086 514 GGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
242-448 |
2.11e-15 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 78.28 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 242 AAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVKPT----HLALQAVELNTLINHS 317
Cdd:PRK09835 266 SADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADnnqlIPEKKMLDLADEVGKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 318 LQLVSQDANSREIQLRFtaNDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQ 397
Cdd:PRK09835 346 FDFFEAWAEERGVELRF--VGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEH 423
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 447134643 398 LEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASqEGKGATFTLWLP 448
Cdd:PRK09835 424 LPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
4.03e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 70.94 E-value: 4.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAIGqhGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA----EGTGLGLAVVHNIVE 425
Cdd:cd16950 1 LKRVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 447134643 426 QHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-447 |
6.21e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 70.90 E-value: 6.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 343 IQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESgAGVKISVTDSGKGIAADQLEAIFTPYF---TTKAEGTGLGLAV 419
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSI 85
|
90 100
....*....|....*....|....*...
gi 447134643 420 VHNIVEQHGGTIQVASQEGKGATFTLWL 447
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-449 |
1.29e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 69.38 E-value: 1.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNI 423
Cdd:cd16939 1 MARALDNLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*.
gi 447134643 424 VEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
246-440 |
8.87e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 73.14 E-value: 8.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 246 AHEIRNPLSSIKGLAKyFAERA--SAGGEAHQLAQvMAKEADRLNRVVSELLELVKPTHLA----LQAVELNTLINHSLQ 319
Cdd:PRK10337 245 AHELRSPLAALKVQTE-VAQLSddDPQARKKALLQ-LHAGIDRATRLVDQLLTLSRLDSLDnlqdVAEIPLEDLLQSAVM 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 320 LVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGagvkISVTDSGKGIAADQLE 399
Cdd:PRK10337 323 DIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPEALA 398
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 447134643 400 AIFTPYFT---TKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKG 440
Cdd:PRK10337 399 RIGERFYRppgQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
194-450 |
1.26e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 72.36 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 194 TLIILFALATVLLASVLSFFWYRRYLRSRQLLQDEMKRKEKLVaLGHLAAGVAHEIRNPLSSIKGLA---KYFAERASAG 270
Cdd:COG2972 157 RLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGD-LVRLEVSGNDEIGILARSFNEMVeriKELIEEVYEL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 271 GEAHQLAQVMAKEAdRLNR--------VVSELLELVKPTHLALQAVELNTLINHSLQLVSQDA-NSREI----------Q 331
Cdd:COG2972 236 ELEKKEAELKALQA-QINPhflfntlnSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVtLEEELeliksyleiqK 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 332 LRFtaNDTLP-EIQADPDRLTQVLLNLYL-----NAIQA----IGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 401
Cdd:COG2972 315 LRF--GDRLEvEIEIDEELLDLLIPKLILqplveNAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKL 392
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 447134643 402 FTPyFTTKAEGTGLGLAVVHNIVEQH---GGTIQVASQEGKGATFTLWLPVN 450
Cdd:COG2972 393 LEE-LSSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIPLE 443
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
348-448 |
4.10e-13 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 67.22 E-value: 4.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 348 DRLTQVLLNLYLNAI----------QAIGQ--HGVISVTASESGAGVKISVTDSGKGI---------------AADQLEA 400
Cdd:cd16916 37 EKLADPLTHLLRNAVdhgieapeerLAAGKppEGTITLRAEHQGNQVVIEVSDDGRGIdrekirekaiergliTADEAAT 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447134643 401 ---------IFTPYFTTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:cd16916 117 lsddevlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
274-449 |
1.12e-12 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 69.83 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 274 HQLAQVMAKEADRLNRVVSELLELVkpthLALQAVELNTLINHSLQLVSQDANS--REIQLRFTANDT------LPEIqA 345
Cdd:COG0643 205 DESLRELEEALEQLSRLTRELQDGV----MRLRMVPISTVFNRFPRMVRDLARElgKEVELVIEGEETeldrtvLERL-G 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 346 DPdrltqvLLNLYLNAI----------QAIG--QHGVISVTASESGAGVKISVTDSGKGI---------------AADQL 398
Cdd:COG0643 280 DP------LVHLVRNAVdhgietpeerLAAGkpETGTITLSAYHEGGRVVIEVSDDGRGLdlekirakaiekgliTAEEA 353
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447134643 399 EA---------IFTPYFTTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:COG0643 354 AAlsdeellelIFAPGFSTAEEvtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-447 |
2.52e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 63.69 E-value: 2.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 344 QADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFT------TKAEGTGLGL 417
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTledsrnSAKQGNGLGL 94
|
90 100 110
....*....|....*....|....*....|
gi 447134643 418 AVVHNIVEQHGGTIQVASQEGKGATFTLWL 447
Cdd:cd16947 95 TITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
2.82e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.98 E-value: 2.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAI-GQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEG------TGLGLAVVHN 422
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 447134643 423 IVEQHGGTIQVASQE----GKGATFTLWLP 448
Cdd:cd16953 81 IIEAHGGISVAENHNqpgqVIGARFTVQLP 110
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
235-299 |
3.55e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.46 E-value: 3.55e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447134643 235 LVALGHLAAGVAHEIRNPLSSIKGLAKYFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVK 299
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-445 |
5.44e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.09 E-value: 5.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 346 DPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFT-----TKAEGTGLGLAVV 420
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFV 80
|
90 100
....*....|....*....|....*.
gi 447134643 421 HNIVEQHGGTIQVAS-QEGKGATFTL 445
Cdd:cd16945 81 QEVAQLHGGRITLRNrPDGVLAFLTL 106
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
309-443 |
6.54e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 62.65 E-value: 6.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 309 ELNTLINhSLQLVSQDANsREIQLRFTANDTLPeiqADPDRLTQVLLNLYLNAIQ-AIGQhgvISVTASESGAGVKISVT 387
Cdd:cd16954 2 LLDSLCS-ALNKVYQRKG-VSISLDISPELRFP---GERNDLMELLGNLLDNACKwCLEF---VEVTARQTDGGLHLIVD 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 447134643 388 DSGKGIAADQLEAIFT--PYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATF 443
Cdd:cd16954 74 DDGPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARF 131
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
1.55e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 60.86 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF----TTKAEGTGLGLAVVHNIVE 425
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|...
gi 447134643 426 QHGGTIQvASQEGKGATFTLWLP 448
Cdd:cd16923 81 LHGGSAS-AEYDDNHDLFKVRLP 102
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
237-299 |
2.02e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.15 E-value: 2.02e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447134643 237 ALGHLAAGVAHEIRNPLSSIKGLAKyFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVK 299
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLE-LLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
237-302 |
2.19e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 59.12 E-value: 2.19e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447134643 237 ALGHLAAGVAHEIRNPLSSIKGLAKyFAERASAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTH 302
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLE-LLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-448 |
2.49e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 60.38 E-value: 2.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 360 NAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK-----AEGTGLGLAVVHNIVEQHGGTIQVA 434
Cdd:cd16948 16 NALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGHKIDVE 95
|
90
....*....|....
gi 447134643 435 SQEGKGATFTLWLP 448
Cdd:cd16948 96 SEVGEGTTFTITFP 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
343-448 |
2.85e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 65.77 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 343 IQADPDRLTQVLLNLYLNAIQaIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA------EGTGLG 416
Cdd:PRK10841 556 LNGDPMRLQQVISNLLSNAIK-FTDTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrnfQGTGLG 634
|
90 100 110
....*....|....*....|....*....|..
gi 447134643 417 LAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:PRK10841 635 LAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
223-455 |
4.05e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 64.22 E-value: 4.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 223 QLLQ--DEMKRKEKLvalghLAAGVAHEIRNPLSSIKgLAKYFAERASaggeaHQLAQVMAKEADRLNRVVSELLELVKP 300
Cdd:PRK10755 125 QLVSrlTSTLDQERL-----FTADVAHELRTPLAGIR-LHLELLEKQH-----HIDVAPLIARLDQMMHTVEQLLQLARA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 301 TH-LA---LQAVEL-NTLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTA 375
Cdd:PRK10755 194 GQsFSsghYQTVKLlEDVILPSQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKL 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 376 SESGAGVKISVTDSGKGIAADQLEAIFTPY--FTTKAEGTGLGLAVVHNIVEQHGGTIQVAS-QEGKGATFTLWLPVNIT 452
Cdd:PRK10755 274 SQEDGGAVLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLPKAQN 353
|
...
gi 447134643 453 RKD 455
Cdd:PRK10755 354 VAN 356
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-446 |
5.99e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.40 E-value: 5.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 346 DPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGT-----GLGLAVV 420
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIA 80
|
90 100
....*....|....*....|....*.
gi 447134643 421 HNIVEQHGGTIQVASQEGKGATFTLW 446
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-448 |
1.09e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 58.37 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 356 NLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGG 429
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIErcrntgGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 447134643 430 TIQVASQEGKGATFTLWLP 448
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
346-452 |
6.45e-10 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 61.40 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 346 DPDRLTQVLLNLYLNAIQaIGQHGVISV-----TASESGAGVKISVTDSGKGIAADQLEAIFTPYftTKAE--------G 412
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIK-FTESGNIDIlvelrALSNTKVQLEVQIRDTGIGISERQQSQLFQAF--RQADasisrrhgG 481
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 447134643 413 TGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 452
Cdd:PRK11107 482 TGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDLN 521
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
195-449 |
2.80e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 57.71 E-value: 2.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 195 LIILFALATVLLASVLSFFWYR-RYLRSRQLLQDEMKRKEKLVALG---HLAA----GVAHEirnpLSSIK----GLAKY 262
Cdd:COG4585 7 LGALALLVGALLGLLLALVLLRaRRAERAAELERELAARAEEAREEerrRIARelhdGVGQS----LSAIKlqleAARRL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 263 FAERASAGGEAHQLAQVMAKEA-DRLNRVVSELLELVKPTHLALQAVElntlinhslQLVSQDANSREIQLRFTANDTLP 341
Cdd:COG4585 83 LDADPEAAREELEEIRELAREAlAELRRLVRGLRPPALDDLGLAAALE---------ELAERLLRAAGIRVELDVDGDPD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 342 EIQADpdrltqVLLNLYL-------NAIQaigqHG---VISVTASESGAGVKISVTDSGKGIAADQleaiftpyfttkAE 411
Cdd:COG4585 154 RLPPE------VELALYRivqealtNALK----HAgatRVTVTLEVDDGELTLTVRDDGVGFDPEA------------AP 211
|
250 260 270
....*....|....*....|....*....|....*...
gi 447134643 412 GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 449
Cdd:COG4585 212 GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
305-449 |
1.07e-08 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 57.22 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 305 LQAVELNTLINHSLQLVSQDANSREIQLRFTAndtlPEIQADPDRLTQV--LLN-LYLNAIQ---AIGQHGVISVTASES 378
Cdd:COG3920 356 WEGVDLRDYLRELLEPLRDSYGGRGIRIELDG----PDVELPADAAVPLglILNeLVTNALKhafLSGEGGRIRVSWRRE 431
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447134643 379 GAGVKISVTDSGKGIAADqleaiftpyfTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEgkGATFTLWLPV 449
Cdd:COG3920 432 DGRLRLTVSDNGVGLPED----------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPL 490
|
|
| PRK10547 |
PRK10547 |
chemotaxis protein CheA; Provisional |
363-448 |
2.55e-05 |
|
chemotaxis protein CheA; Provisional
Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 46.65 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 363 QAIGQHGV--ISVTASESGAGVKISVTDSGKGIAADQLEA---------------------IFTPYFTTkAE------GT 413
Cdd:PRK10547 409 LAAGKNSVgnLILSAEHQGGNICIEVTDDGAGLNRERILAkaasqglavsenmsdeevgmlIFAPGFST-AEqvtdvsGR 487
|
90 100 110
....*....|....*....|....*....|....*
gi 447134643 414 GLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:PRK10547 488 GVGMDVVKRNIQEMGGHVEIQSKQGKGTTIRILLP 522
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
340-448 |
1.57e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 44.05 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 340 LPEiQADPDRLTQVLLNLYLNAIQAIGQ----HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGT-- 413
Cdd:PRK15053 424 LPP-GLDSTEFAAIVGNLLDNAFEASLRsdegNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPge 502
|
90 100 110
....*....|....*....|....*....|....*.
gi 447134643 414 -GLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 448
Cdd:PRK15053 503 hGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-448 |
2.03e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 40.51 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 360 NAIQAIGQH----GVISVTASESGAGVKISVTDSGKGIAADQLEAIftpyFTTKAEGTGLGLAVVHNIV-----EQHGgt 430
Cdd:cd16924 12 NAIQHGLSPltdkGVVTISALKEDNHVMIEVEDNGRGIDPKVLNIL----GKKPKEGNGIGLYNVHQRLillfgEDYG-- 85
|
90
....*....|....*...
gi 447134643 431 IQVASQEGKGATFTLWLP 448
Cdd:cd16924 86 IHIASEPDKGTRITFTIP 103
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
371-441 |
2.72e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 43.08 E-value: 2.72e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447134643 371 ISVTASESGAGVKISVTDSGKGIAADQLEAIFT--PYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGA 441
Cdd:PRK10815 398 VEISARQTDEHLHIVVEDDGPGIPESKRELIFDrgQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGA 470
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
331-426 |
3.88e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.28 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 331 QLRFTANDTLPEIQADPDRLTQVLLNLY---LNAIQ---AIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEaiftP 404
Cdd:COG2172 13 LARRAVRALLRELGLDEDDADDLVLAVSeavTNAVRhayGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP----D 88
|
90 100
....*....|....*....|..
gi 447134643 405 YFTTKAEGtGLGLAVVHNIVEQ 426
Cdd:COG2172 89 PYSTLAEG-GRGLFLIRRLMDE 109
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
369-445 |
4.06e-04 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 40.21 E-value: 4.06e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447134643 369 GVISVTASESGAGVKISVTDSGKGIaaDQLEAIFTPYFTTKA--EGTGLGLAVVHNIVEQhggtIQVASQEGKGATFTL 445
Cdd:cd16942 61 GIVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTTKPelERSGMGFTIMENFMDE----VIVESEVNKGTTVYL 133
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
310-445 |
4.61e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 40.25 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 310 LNTLINHSLQLvsqdANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQA----IGQHGVISVTASESGAGVKIS 385
Cdd:cd16935 2 LDSLLSEKLEL----AREKGIEFTIEIDIPI-LLPISPLDLCIIFGNLLDNAIEAcakiDKENRFIHLKIRQKKGFLIIS 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447134643 386 VTDSGKGiaadQLEAIFTPYFTTKAE-GTGLGLAVVHNIVEQHGGTIQVASQEGKgatFTL 445
Cdd:cd16935 77 IENSYEG----ELKKKNGLFLSTKKDkNHGIGLKSIREIVKKYNGNLSIEYENGI---FTL 130
|
|
| sCache_3_2 |
pfam17203 |
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ... |
40-157 |
2.22e-03 |
|
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435783 [Multi-domain] Cd Length: 140 Bit Score: 38.16 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 40 RETAAARQTLLEKGSVLIRAL--ESGSRVGMGMRMHHAQQQALLEEMAGQPGVRWFAVTDEQGTIVMHSNSGMMGKQLYS 117
Cdd:pfam17203 1 QLRADLTRQLERRALALARSVaaSPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSG 80
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 447134643 118 PQEMQQLHPGdeEAWRRIDSADGEPVLEIYRqfqPMFAAG 157
Cdd:pfam17203 81 PATAPALTAG--RSYTGTVTGTLGPSLDAKL---PIFDAD 115
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
350-445 |
3.04e-03 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 37.19 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQA---IGQHGVISVTASESGAGVKISV--TDSGKGIAADQLeaiftPYFTTKAEGTGLGLAVVHNIV 424
Cdd:pfam14501 6 LCVIFGNLLDNAIEAcskIDDNRFIRLKIREKQNFLIIRIenTYEGELKFEGKL-----PSTKTKGDGHGIGLKSIRRIV 80
|
90 100
....*....|....*....|.
gi 447134643 425 EQHGGTIQVASQEGkgaTFTL 445
Cdd:pfam14501 81 KKYGGNLSTEIENG---IFTL 98
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-448 |
3.89e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 37.02 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 371 ISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKaEGTGLGLavvHNIVEQHGG------TIQVASQEGKGATFT 444
Cdd:cd16957 27 VRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE-KGTGTAL---ENLNRRLIGlfgseaCLHIESEVHGGTEVW 102
|
....
gi 447134643 445 LWLP 448
Cdd:cd16957 103 FVIP 106
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-448 |
4.66e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 37.40 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 350 LTQVLLNLYLNAIQAiGQHGVISVTASESGAGVKISVTDSGKGIaadqleaiftPYFTTKAEGTGLGLAVVHNIVEQHGG 429
Cdd:cd16951 44 VNELLQNALKHAFSD-REGGTITIRSVVDGDYLRITVIDDGVGL----------PQDEDWPNKGSLGLQIVRSLVEGELK 112
|
90
....*....|....*....
gi 447134643 430 TIQVASQEGKGATFTLWLP 448
Cdd:cd16951 113 AFLEVQSAENGTRVNIDIP 131
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
360-447 |
6.75e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 35.71 E-value: 6.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447134643 360 NAIQ---AIGQHGVISVTASESGAGVKISVTDSGKGIAadqLEAIFTPYfTTKAEGtGLGLAVVHNIVEQHGGTiqvASQ 436
Cdd:cd16936 11 NAVRhayRHDGPGPVRLELDLDPDRLRVEVTDSGPGFD---PLRPADPD-AGLREG-GRGLALIRALMDEVGYR---RTP 82
|
90
....*....|.
gi 447134643 437 EGKgatfTLWL 447
Cdd:cd16936 83 GGK----TVWL 89
|
|
| |
