NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|447142925|ref|WP_001220181|]
View 

MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Enterobacteriaceae]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007814)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0090729
PubMed:  20143871|20487277|28279904|15718296

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-95 4.95e-20

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


:

Pssm-ID: 442885  Cd Length: 96  Bit Score: 76.85  E-value: 4.95e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447142925  4 IKLMPKANEDLEGIWYYSYHHFGEPQADRYVEHLSDVLQILSNN-NIGTPRPELG-EGIFVLPFERHVIYFLQSPGEIIV 81
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDWGPEAAERYLDEIEEAIELLAEFpELGRPRPELRvPGLRELVVGPYVIFYRVDDDTVEI 82

                        90
                ....*....|....
gi 447142925 82 IRILNQNQDATRHL 95
Cdd:COG3668  83 LRVLHGRRDLPALL 96
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-95 4.95e-20

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 76.85  E-value: 4.95e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447142925  4 IKLMPKANEDLEGIWYYSYHHFGEPQADRYVEHLSDVLQILSNN-NIGTPRPELG-EGIFVLPFERHVIYFLQSPGEIIV 81
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDWGPEAAERYLDEIEEAIELLAEFpELGRPRPELRvPGLRELVVGPYVIFYRVDDDTVEI 82

                        90
                ....*....|....
gi 447142925 82 IRILNQNQDATRHL 95
Cdd:COG3668  83 LRVLHGRRDLPALL 96
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 4-90 2.38e-10

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 52.05  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447142925   4 IKLMPKANEDLEGIWYYsYHHFGEPQADRYVEHLSDVLQILSNN-NIGTPRPELG-EGIFVLPFERHVIYFLQSPGEII- 80
Cdd:pfam05016  1 VILTPKALKDLKKIADY-IAQDNPDAAERFLKALEEALELLAENpALGRPLPEGGlKGLRRIRIGDYRIIYRIDDDDLVi 79

                         90
                 ....*....|.
gi 447142925  81 -VIRILNQNQD 90
Cdd:pfam05016 80 lILRVGHRRRD 90
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-95 4.95e-20

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 76.85  E-value: 4.95e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447142925  4 IKLMPKANEDLEGIWYYSYHHFGEPQADRYVEHLSDVLQILSNN-NIGTPRPELG-EGIFVLPFERHVIYFLQSPGEIIV 81
Cdd:COG3668   3 VRWTPEAEADLEEIYDYIAEDWGPEAAERYLDEIEEAIELLAEFpELGRPRPELRvPGLRELVVGPYVIFYRVDDDTVEI 82

                        90
                ....*....|....
gi 447142925 82 IRILNQNQDATRHL 95
Cdd:COG3668  83 LRVLHGRRDLPALL 96
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 4-90 2.38e-10

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 52.05  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447142925   4 IKLMPKANEDLEGIWYYsYHHFGEPQADRYVEHLSDVLQILSNN-NIGTPRPELG-EGIFVLPFERHVIYFLQSPGEII- 80
Cdd:pfam05016  1 VILTPKALKDLKKIADY-IAQDNPDAAERFLKALEEALELLAENpALGRPLPEGGlKGLRRIRIGDYRIIYRIDDDDLVi 79

                         90
                 ....*....|.
gi 447142925  81 -VIRILNQNQD 90
Cdd:pfam05016 80 lILRVGHRRRD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH