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Conserved domains on  [gi|447149183|ref|WP_001226439|]
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MULTISPECIES: putative holin [Salmonella]

Protein Classification

putative holin( domain architecture ID 10594037)

putative holin with 2 or 3 transmembrane segments may function in the transport of murein hydrolases (endolysins) across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Holin_2-3 pfam13272
Putative 2/3 transmembrane domain holin; Holin_2-3 is a putative holins with 2 or 3 ...
 9-95 2.11e-26

Putative 2/3 transmembrane domain holin; Holin_2-3 is a putative holins with 2 or 3 transmembrane segments. It consists of many proteobacterial proteins ranging in size from about 70 aas to 120 aas. They have 2 or 3 predicted TMSs. Although some are annotated as phage proteins or holins, none appears to be functionally characterized.


:

Pssm-ID: 433075  Cd Length: 106  Bit Score: 93.57  E-value: 2.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447149183    9 LSGWLIASVVLFALIGWTSSAQIPVVIYKLSLVSLSAVLGYWLDRSLFPWARPDSF-------------------CPWEE 69
Cdd:pfam13272   1 LLWWLLIALVLLLVVALISPQQLPVVLYKLSLVTLAAVLGYWLDRWLFPYARPGSYlcedwrhegdfldgradypVVRGY 80

                          90       100
                  ....*....|....*....|....*.
gi 447149183   70 SLCCAAAMIRRAIIVAAICLAVALGL 95
Cdd:pfam13272  81 ETVFAAAMLRRAVIVAAAMLAVGLGL 106
 
Name Accession Description Interval E-value
Holin_2-3 pfam13272
Putative 2/3 transmembrane domain holin; Holin_2-3 is a putative holins with 2 or 3 ...
 9-95 2.11e-26

Putative 2/3 transmembrane domain holin; Holin_2-3 is a putative holins with 2 or 3 transmembrane segments. It consists of many proteobacterial proteins ranging in size from about 70 aas to 120 aas. They have 2 or 3 predicted TMSs. Although some are annotated as phage proteins or holins, none appears to be functionally characterized.


Pssm-ID: 433075  Cd Length: 106  Bit Score: 93.57  E-value: 2.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447149183    9 LSGWLIASVVLFALIGWTSSAQIPVVIYKLSLVSLSAVLGYWLDRSLFPWARPDSF-------------------CPWEE 69
Cdd:pfam13272   1 LLWWLLIALVLLLVVALISPQQLPVVLYKLSLVTLAAVLGYWLDRWLFPYARPGSYlcedwrhegdfldgradypVVRGY 80

                          90       100
                  ....*....|....*....|....*.
gi 447149183   70 SLCCAAAMIRRAIIVAAICLAVALGL 95
Cdd:pfam13272  81 ETVFAAAMLRRAVIVAAAMLAVGLGL 106
 
Name Accession Description Interval E-value
Holin_2-3 pfam13272
Putative 2/3 transmembrane domain holin; Holin_2-3 is a putative holins with 2 or 3 ...
 9-95 2.11e-26

Putative 2/3 transmembrane domain holin; Holin_2-3 is a putative holins with 2 or 3 transmembrane segments. It consists of many proteobacterial proteins ranging in size from about 70 aas to 120 aas. They have 2 or 3 predicted TMSs. Although some are annotated as phage proteins or holins, none appears to be functionally characterized.


Pssm-ID: 433075  Cd Length: 106  Bit Score: 93.57  E-value: 2.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447149183    9 LSGWLIASVVLFALIGWTSSAQIPVVIYKLSLVSLSAVLGYWLDRSLFPWARPDSF-------------------CPWEE 69
Cdd:pfam13272   1 LLWWLLIALVLLLVVALISPQQLPVVLYKLSLVTLAAVLGYWLDRWLFPYARPGSYlcedwrhegdfldgradypVVRGY 80

                          90       100
                  ....*....|....*....|....*.
gi 447149183   70 SLCCAAAMIRRAIIVAAICLAVALGL 95
Cdd:pfam13272  81 ETVFAAAMLRRAVIVAAAMLAVGLGL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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