glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
4-365
2.99e-54
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
The actual alignment was detected with superfamily member TIGR04516:
Pssm-ID: 471961 Cd Length: 418 Bit Score: 184.38 E-value: 2.99e-54
glycosyltransferase, activator-dependent family; Many biosynthesis clusters for secondary ...
4-365
2.99e-54
glycosyltransferase, activator-dependent family; Many biosynthesis clusters for secondary metabolites feature a glycosyltransferase gene next to a P450 homolog, often with the P450 lacking a critical heme-binding Cys. These P540-derived sequences seem to be allosteric activators of glycosyltransferases such as the member of this family. This model describes a set of related glycosyltransferases, many of which can be recognized as activator-dependent from genomic context.
Pssm-ID: 275309 Cd Length: 418 Bit Score: 184.38 E-value: 2.99e-54
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
4-363
3.72e-48
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.
Pssm-ID: 340817 [Multi-domain] Cd Length: 404 Bit Score: 167.73 E-value: 3.72e-48
Protein of unknown function (DUF1205); This family represents a conserved region of unknown ...
164-259
1.31e-33
Protein of unknown function (DUF1205); This family represents a conserved region of unknown function within bacterial glycosyl transferases. Many family members contain pfam03033.
Pssm-ID: 369050 Cd Length: 95 Bit Score: 120.31 E-value: 1.31e-33
Semialdehyde dehydrogenase, NAD binding domain; The semialdehyde dehydrogenase family is found ...
2-55
2.15e-03
Semialdehyde dehydrogenase, NAD binding domain; The semialdehyde dehydrogenase family is found in N-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in arginine biosynthesis, and aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. This family is also found in yeast and fungal Arg5,6 protein, which is cleaved into the enzymes N-acety-gamma-glutamyl-phosphate reductase and acetylglutamate kinase. These are also involved in arginine biosynthesis. All proteins in this entry contain a NAD binding region of semialdehyde dehydrogenase.
Pssm-ID: 214863 [Multi-domain] Cd Length: 123 Bit Score: 37.53 E-value: 2.15e-03
glycosyltransferase, activator-dependent family; Many biosynthesis clusters for secondary ...
4-365
2.99e-54
glycosyltransferase, activator-dependent family; Many biosynthesis clusters for secondary metabolites feature a glycosyltransferase gene next to a P450 homolog, often with the P450 lacking a critical heme-binding Cys. These P540-derived sequences seem to be allosteric activators of glycosyltransferases such as the member of this family. This model describes a set of related glycosyltransferases, many of which can be recognized as activator-dependent from genomic context.
Pssm-ID: 275309 Cd Length: 418 Bit Score: 184.38 E-value: 2.99e-54
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
4-363
3.72e-48
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.
Pssm-ID: 340817 [Multi-domain] Cd Length: 404 Bit Score: 167.73 E-value: 3.72e-48
Protein of unknown function (DUF1205); This family represents a conserved region of unknown ...
164-259
1.31e-33
Protein of unknown function (DUF1205); This family represents a conserved region of unknown function within bacterial glycosyl transferases. Many family members contain pfam03033.
Pssm-ID: 369050 Cd Length: 95 Bit Score: 120.31 E-value: 1.31e-33
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
11-368
1.55e-27
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]
Pssm-ID: 273616 [Multi-domain] Cd Length: 392 Bit Score: 111.70 E-value: 1.55e-27
Semialdehyde dehydrogenase, NAD binding domain; The semialdehyde dehydrogenase family is found ...
2-55
2.15e-03
Semialdehyde dehydrogenase, NAD binding domain; The semialdehyde dehydrogenase family is found in N-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in arginine biosynthesis, and aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. This family is also found in yeast and fungal Arg5,6 protein, which is cleaved into the enzymes N-acety-gamma-glutamyl-phosphate reductase and acetylglutamate kinase. These are also involved in arginine biosynthesis. All proteins in this entry contain a NAD binding region of semialdehyde dehydrogenase.
Pssm-ID: 214863 [Multi-domain] Cd Length: 123 Bit Score: 37.53 E-value: 2.15e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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