|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
5-380 |
5.34e-87 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 268.73 E-value: 5.34e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 5 AFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIESSLTLSELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFS 84
Cdd:COG5002 9 LALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 85 IFSSYLYIFYRHERKLYYETCIKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQAEQAKSEL 164
Cdd:COG5002 89 LLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 165 ITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQ 244
Cdd:COG5002 169 VANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 245 LTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPST 324
Cdd:COG5002 249 VVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEE 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447166045 325 DLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:COG5002 329 DLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKgTTFTITL 385
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
146-380 |
4.86e-80 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 245.59 E-value: 4.86e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 146 QLKVSIDEERQAEQAKSELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQ 225
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 226 NKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYE 305
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447166045 306 SNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRstNTGGSGLGLAIAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSR--GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTL 234
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
144-380 |
8.36e-68 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 217.08 E-value: 8.36e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 144 VEQLKVSIDEERQAEQAKSELITNVSHDLRTPLTSIVGYVNLIHHDnyrDEVELRHYIQVIYDKVTRLNALMNDLFEYTR 223
Cdd:COG0642 93 LLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE---LDEEQREYLETILRSADRLLRLINDLLDLSR 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 224 VQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITA 303
Cdd:COG0642 170 LEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSV 249
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447166045 304 YESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRstNTGGSGLGLAIAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:COG0642 250 RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSR--RGGGTGLGLAIVKRIVELHGGTIEVESEPGKgTTFTVTL 325
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
155-380 |
7.79e-50 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 170.47 E-value: 7.79e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 155 RQAEQAKSELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSV 234
Cdd:TIGR02966 108 RRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDE 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 235 PIDIVELLGQLTVQFRIQLQEAN----IDCRPffpskKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMI 310
Cdd:TIGR02966 188 PVDMPALLDHLRDEAEALSQGKNhqitFEIDG-----GVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGA 262
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447166045 311 AIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVKL 380
Cdd:TIGR02966 263 EFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESElGKGSTFSFIF 333
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
143-383 |
5.55e-48 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 171.47 E-value: 5.55e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 143 IVEQLKvsIDEERQaeqaksELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEvEL-RHYIQVIYDKVTRLNALMNDLFEY 221
Cdd:NF033092 362 VTEQEK--IEQERR------EFVANVSHELRTPLTTMRSYLEALADGAWKDP-ELaPRFLGVTQNETERMIRLVNDLLQL 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 222 TRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDI 301
Cdd:NF033092 433 SRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITF 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 302 TAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYS-DDKKTTFTVKL 380
Cdd:NF033092 513 RLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESeEGKGTTIYFTL 592
|
...
gi 447166045 381 qPY 383
Cdd:NF033092 593 -PY 594
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
151-380 |
1.74e-45 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 161.67 E-value: 1.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 151 IDEERQAEQAKS--ELITNVSHDLRTPLTSIVGYVNLIHHDnYRDEVE-----LRHYIQVIYDKVTRLNALMNDLFEYTR 223
Cdd:COG5000 189 ITELLRAERLAAwgELARRIAHEIKNPLTPIQLSAERLRRK-LADKLEedredLERALDTIIRQVDRLKRIVDEFLDFAR 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 224 VQNKELSlysvPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITA 303
Cdd:COG5000 268 LPEPQLE----PVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVST 343
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447166045 304 YESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEVYS-DDKKTTFTVKL 380
Cdd:COG5000 344 RREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESrPGGGTTFTIRL 415
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
30-380 |
1.25e-39 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 147.24 E-value: 1.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 30 ITELIIYRLVTSVIESSLTLSELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHERKLYYETCIKKM 109
Cdd:COG4251 141 ALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLS 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 110 IEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQAEQAKSEL-ITN---------VSHDLRTPLTSI 179
Cdd:COG4251 221 LGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELeRSNeeleqfayvASHDLREPLRKI 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 180 VGYVNLIHHDnYRDEV--ELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLysVPIDIVELLGQLTVQFRIQLQEAN 257
Cdd:COG4251 301 SGFSQLLEED-YGDKLdeEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEF--EPVDLNELLEEVLEDLEPRIEERG 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 258 --IDCRPFfpskkLMVLADGDKLVRVFENLIINAIAYGNDGDY--IDITAYESNNMIAIDITNYGQPIPSTDLPHIFERF 333
Cdd:COG4251 378 aeIEVGPL-----PTVRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIF 452
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 447166045 334 YRVekSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVKL 380
Cdd:COG4251 453 QRL--HSRDEYEGTGIGLAIVKKIVERHGGRIWVESEpGEGATFYFTL 498
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
133-380 |
1.06e-38 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 144.07 E-value: 1.06e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 133 LEELASGVNQIVEQLKvsideerQAEQAKSELITNVSHDLRTPLTSIVGY--VNLIHHdnyRDEVELRHYIQVIYDKVTR 210
Cdd:TIGR01386 220 LRELAQSFNAMLGRLE-------DAFQRLSQFSADLAHELRTPLTNLLGQtqVALSQP---RTGEEYREVLESNLEELER 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 211 LNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPffpSKKLMVLADGDKLVRVFENLIINAI 290
Cdd:TIGR01386 290 LSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRV---EGEGLVRGDPQMFRRAISNLLSNAL 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 291 AYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSD 370
Cdd:TIGR01386 367 RHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESP 446
|
250
....*....|
gi 447166045 371 DKKTTFTVKL 380
Cdd:TIGR01386 447 DGKTRFILRF 456
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
153-380 |
1.11e-37 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 139.21 E-value: 1.11e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 153 EERQAEQAKS--ELITNVSHDLRTPLTSIVGYVNLIHHDNyrDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELS 230
Cdd:COG3852 125 ELRRAEKLAAvgELAAGLAHEIRNPLTGIRGAAQLLEREL--PDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPERE 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 231 lysvPIDIVELLGQLTVQFRIQLQeANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAI-AYGNDG---------DYID 300
Cdd:COG3852 203 ----PVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAeAMPEGGtitirtrveRQVT 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 301 ITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEVYS-DDKKTTFTVK 379
Cdd:COG3852 278 LGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESePGKGTTFRIY 351
|
.
gi 447166045 380 L 380
Cdd:COG3852 352 L 352
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
32-380 |
1.00e-36 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 136.47 E-value: 1.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 32 ELIIYRLVTSVIESSLTLSELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSyLYIFYRHERKLYYETCIKKMIE 111
Cdd:COG4191 5 LLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLL-LELLLLLLALLGGLLRLLLLLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 112 EIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQAE-----QAK----SELITNVSHDLRTPLTSIVGY 182
Cdd:COG4191 84 LLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQeqlvqSEKlaalGELAAGIAHEINNPLAAILGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 183 VNLIHH--DNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELslysVPIDIVELLGQLTVQFRIQLQEANIDC 260
Cdd:COG4191 164 AELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEER----EPVDLNELIDEALELLRPRLKARGIEV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 261 RPFFPSKKLMVLADGDKLVRVFENLIINAI-AY-GNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFY---R 335
Cdd:COG4191 240 ELDLPPDLPPVLGDPGQLEQVLLNLLINAIdAMeEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkP 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447166045 336 VEKsrstntgGSGLGLAIAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:COG4191 320 VGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGgTTFTITL 358
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
106-365 |
4.76e-34 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 131.29 E-value: 4.76e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 106 IKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLkvsideERQaEQAKSELITNVSHDLRTPLTSIVGYVNL 185
Cdd:PRK10549 192 VKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTL------EKN-EQMRRDFMADISHELRTPLAVLRGELEA 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 186 IHHDNYRDEVELRHYIQViydKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPFFP 265
Cdd:PRK10549 265 IQDGVRKFTPESVASLQA---EVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLP 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 266 sKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTG 345
Cdd:PRK10549 342 -DSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASG 420
|
250 260
....*....|....*....|
gi 447166045 346 GSGLGLAIAKSIVELHKGTI 365
Cdd:PRK10549 421 GSGLGLAICLNIVEAHNGRI 440
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
278-380 |
1.13e-31 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 115.39 E-value: 1.13e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRstNTGGSGLGLAIAKSI 357
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSR--EGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 447166045 358 VELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:cd00075 79 VEAHGGRITVESEPGGgTTFTVTL 102
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
133-380 |
2.23e-31 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 124.11 E-value: 2.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 133 LEELASGVNQIVEQLkvsidEERQAEQAKseLITNVSHDLRTPLTSIVGYVNLIHHDNyRDEVELRhyiQVIY---DKVT 209
Cdd:PRK09835 241 LEQLVLSFNHMIERI-----EDVFTRQSN--FSADIAHEIRTPITNLITQTEIALSQS-RSQKELE---DVLYsnlEELT 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 210 RLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRpfFPSKKLMVLADGDKLVRVFENLIINA 289
Cdd:PRK09835 310 RMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELR--FVGDPCQVAGDPLMLRRAISNLLSNA 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 290 IAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYS 369
Cdd:PRK09835 388 LRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS 467
|
250
....*....|.
gi 447166045 370 DDKKTTFTVKL 380
Cdd:PRK09835 468 DARGTRFVISL 478
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-380 |
6.37e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 113.64 E-value: 6.37e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRstNTGGSGLGLAIAKSI 357
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|...
gi 447166045 358 VELHKGTIEVYSDDKKTTFTVKL 380
Cdd:cd16923 79 IELHGGSASAEYDDNHDLFKVRL 101
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
155-381 |
1.25e-30 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 123.15 E-value: 1.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 155 RQAEQ--AKSELITNVSHDLRTPLTSIVGYVNLIHhdNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRvQNKElslY 232
Cdd:PRK11360 382 ARQERlaALGELVAGVAHEIRNPLTAIRGYVQIWR--QQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR-PRES---Q 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 233 SVPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAI-AYGNDGDyIDI-TAYESNNMI 310
Cdd:PRK11360 456 WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVqAISARGK-IRIrTWQYSDGQV 534
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447166045 311 AIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVKLQ 381
Cdd:PRK11360 535 AVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEpGVGTTFTLYLP 600
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
273-380 |
3.50e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 111.97 E-value: 3.50e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 273 ADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVeKSRSTNTGGSGLGLA 352
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRT-DKRSRKIGGTGLGLS 79
|
90 100
....*....|....*....|....*....
gi 447166045 353 IAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGgTTFTITL 108
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
111-382 |
6.76e-30 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 119.34 E-value: 6.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 111 EEIRYIANGNFNHKVSIV--NHNYLE----ELASGvnqivEQLKVSID--EERQAEQAKSELITNVSHDLRTPLTSIVGY 182
Cdd:PRK11006 151 EFTQYLKTRDFSRPLTLVlnNGRHLEirvmPYTEG-----QLLMVARDvtQMHQLEGARRNFFANVSHELRTPLTVLQGY 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 183 VNLIHHDNYrdEVELRH-YIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELL------------GQLTVQF 249
Cdd:PRK11006 226 LEMMQDQPL--EGALREkALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLrvlereaqtlsqGKHTITF 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 250 RIqlqeanidcrpffpSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHI 329
Cdd:PRK11006 304 EV--------------DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRL 369
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 447166045 330 FERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVKLQP 382
Cdd:PRK11006 370 TERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEvGKGTRFSFVLPE 423
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
116-369 |
5.13e-28 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 114.74 E-value: 5.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 116 IANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQAEQAKSELITNVSHDLRTPLTSIVGYVNLIHhdNYRDEV 195
Cdd:NF040691 226 FAAGDLSERMPVKGEDDLARLARSFNQMADSLQRQIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVIH--DSRDDF 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 196 E--LRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLA 273
Cdd:NF040691 304 DpaTARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEV 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 274 DGDKLVRVFENLIINAIAYGnDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAI 353
Cdd:NF040691 384 DPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAI 462
|
250
....*....|....*.
gi 447166045 354 AKSIVELHKGTIEVYS 369
Cdd:NF040691 463 ALEDARLHGGWLEAWG 478
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
265-381 |
2.51e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 99.51 E-value: 2.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 265 PSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNT 344
Cdd:cd16947 8 PDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAK 87
|
90 100 110
....*....|....*....|....*....|....*...
gi 447166045 345 GGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVKLQ 381
Cdd:cd16947 88 QGNGLGLTITKRLAESMGGSIYVNSKpYEKTVFTVTLK 125
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
151-384 |
5.58e-25 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 105.83 E-value: 5.58e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 151 IDEERQAEQAK---------SELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEvelRHYIQVIYDKVTRLNALMNDLFEY 221
Cdd:COG5809 251 ITERKKLEELLrkseklsvvGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQ---KTYLDIMLSELDRIESIISEFLVL 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 222 TRVQNKELSlysvPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDI 301
Cdd:COG5809 328 AKPQAIKYE----PKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITI 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 302 -TAYESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVK 379
Cdd:COG5809 404 eTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEvGKGTTFSIT 477
|
....*
gi 447166045 380 LqPYK 384
Cdd:COG5809 478 L-PIK 481
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
273-380 |
1.33e-24 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 97.05 E-value: 1.33e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 273 ADGDKLVRVFENLIINAIAYGNDGDYIDITAyESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKsrsTNTGGSGLGLA 352
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100
....*....|....*....|....*....
gi 447166045 353 IAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGgTTVTLTL 105
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
116-367 |
1.47e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 104.30 E-value: 1.47e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 116 IANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQaeqakseLITNVSHDLRTPLtsivgyVNLihhdNYR--- 192
Cdd:PRK10604 174 LGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQ-------LIDGIAHELRTPL------VRL----RYRlem 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 193 ----DEVELrhyiQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPffPSKK 268
Cdd:PRK10604 237 sdnlSAAES----QALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDT--PHQG 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 269 LMVLADGDKLVRVFENLIINAIAYGndGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSG 348
Cdd:PRK10604 311 DYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCG 388
|
250
....*....|....*....
gi 447166045 349 LGLAIAKSIVELHKGTIEV 367
Cdd:PRK10604 389 LGLAIVHSIALAMGGSVNC 407
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
151-381 |
5.98e-24 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 102.89 E-value: 5.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 151 IDEERQAEQ--AKSE-------LITNVSHDLRTPLTSIVGYVNLIHHDnyrdEVELRHYIQVIYDKVTRLNALMNDLFey 221
Cdd:COG5805 268 ITEKKEAEElmARSEklsiagqLAAGIAHEIRNPLTSIKGFLQLLQPG----IEDKEEYFDIMLSELDRIESIISEFL-- 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 222 trVQNKELSLYSVPIDIVELLGQLtvqfrIQLQEA-----NIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDG 296
Cdd:COG5805 342 --ALAKPQAVNKEKENINELIQDV-----VTLLETeailhNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNG 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 297 DYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTT 375
Cdd:COG5805 415 GTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKvGKGTT 488
|
....*.
gi 447166045 376 FTVKLQ 381
Cdd:COG5805 489 FTITLP 494
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
131-372 |
1.69e-23 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 102.42 E-value: 1.69e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 131 NYLEELAsgVNQIVEQLKvsIDEERqaEQAKSELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVelRHYIQV--IYDKV 208
Cdd:PRK10490 640 NALERLT--LTASEEQAR--LASER--EQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGS--PHARQAseIRQQV 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 209 TRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRpfFPSKKLMVLADGDKLVRVFENLIIN 288
Cdd:PRK10490 712 LNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLS--LPEPLTLIHVDGPLFERVLINLLEN 789
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 289 AIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNtgGSGLGLAIAKSIVELHKGTIEVY 368
Cdd:PRK10490 790 AVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIP--GVGLGLAICRAIVEVHGGTIWAE 867
|
....
gi 447166045 369 SDDK 372
Cdd:PRK10490 868 NRPE 871
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
170-367 |
2.65e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 101.07 E-value: 2.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 170 HDLRTPLTSIVGYVNLIHHDNYRDEVelRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQF 249
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPPPEDR--ARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAR 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 250 RIQLQEANIDCRPFFPSkkLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHI 329
Cdd:PRK11100 343 EAQAAAKGITLRLRPDD--ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRI 420
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 447166045 330 FERFY---RVEKSRStntgGSGLGLAIAKSIVELHKGTIEV 367
Cdd:PRK11100 421 FERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTL 457
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
152-380 |
7.96e-23 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 99.48 E-value: 7.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 152 DEERQAEQ--AKSELITNVSHDLRTPLTSIVGYVNLIHhDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRvqNKEL 229
Cdd:PRK10364 226 DEMKRKEKlvALGHLAAGVAHEIRNPLSSIKGLAKYFA-ERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVK--PTHL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 230 SLYsvPIDIVELlgqltVQFRIQLQEANIDCR----PFFPSKKL-MVLADGDKLVRVFENLIINAI-AYGNDGdYIDITA 303
Cdd:PRK10364 303 ALQ--AVDLNDL-----INHSLQLVSQDANSReiqlRFTANDTLpEIQADPDRLTQVLLNLYLNAIqAIGQHG-VISVTA 374
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447166045 304 YESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEVYSDD-KKTTFTVKL 380
Cdd:PRK10364 375 SESGAGVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEgKGATFTLWL 446
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
110-380 |
1.42e-22 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 99.72 E-value: 1.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 110 IEEIRYIAnGNFNHKVSIVNHNYlEELASGVNQIVEQLKVSideERQAEQA---KSELITNVSHDLRTPLTSIVGYVNLI 186
Cdd:PRK15347 349 LDELGSIA-KAYNQLLDTLNEQY-DTLENKVAERTQALAEA---KQRAEQAnkrKSEHLTTISHEIRTPLNGVLGALELL 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 187 HHDNYRDevELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQ--LTVQFRIQLQEANIDC--RP 262
Cdd:PRK15347 424 QNTPLTA--EQMDLADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQamLTIQGPAQSKSLTLRTfvGA 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 263 FFPSKKLMvlaDGDKLVRVFENLIINAIAYGNDGdYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEksrsT 342
Cdd:PRK15347 502 HVPLYLHL---DSLRLRQILVNLLGNAVKFTETG-GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD----T 573
|
250 260 270
....*....|....*....|....*....|....*....
gi 447166045 343 NTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVKL 380
Cdd:PRK15347 574 HSQGTGLGLTIASSLAKMMGGELTLFSTpGVGSCFSLVL 612
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-365 |
2.97e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 90.46 E-value: 2.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDgdYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSI 357
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
....*...
gi 447166045 358 VELHKGTI 365
Cdd:cd16949 79 IEQHGGKI 86
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
274-365 |
7.07e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 89.44 E-value: 7.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 274 DGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAI 353
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90
....*....|..
gi 447166045 354 AKSIVELHKGTI 365
Cdd:cd16946 81 CHNIALAHGGTI 92
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
159-378 |
2.96e-21 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 94.25 E-value: 2.96e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 159 QAKSELITNVSHDLRTPLTSIVGYV-----NLIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYS 233
Cdd:PRK09303 149 KFKDRVLAMLAHDLRTPLTAASLALetlelGQIDEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEALRFNP 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 234 VPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITA-YESNNMIAI 312
Cdd:PRK09303 229 QKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMlHRTTQKVQV 308
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447166045 313 DITNYGQPIPSTDLPHIFERFYRVekSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKT---TFTV 378
Cdd:PRK09303 309 SICDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGscfHFTL 375
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
116-365 |
3.28e-21 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 94.61 E-value: 3.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 116 IANGNFnhkvsiVNHNYLEE-----LASGV--NQIVEqlkvSIDEERQAEQAkseLITNVSHDLRTPLTSIVGYVNLI-- 186
Cdd:PRK09470 204 VAQGNL------RQHPELETgpqefRQAGAsfNQMVT----ALERMMTSQQR---LLSDISHELRTPLTRLQLATALLrr 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 187 HHDNYRDevelrhyIQVIYDKVTRLNALMNDLFEYTRVQ-NKELSLYSVPIDivELLGQLTVQFRIQLQEANIDCRPFFP 265
Cdd:PRK09470 271 RQGESKE-------LERIETEAQRLDSMINDLLVLSRNQqKNHLERETFKAN--SLWSEVLEDAKFEAEQMGKSLTVSAP 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 266 SKKLMVLADGDKLVRVFENLIINAIAYGNDgdYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTG 345
Cdd:PRK09470 342 PGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESG 419
|
250 260
....*....|....*....|
gi 447166045 346 GSGLGLAIAKSIVELHKGTI 365
Cdd:PRK09470 420 GTGLGLAIVENAIQQHRGWV 439
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
151-380 |
4.37e-20 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 92.31 E-value: 4.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 151 IDEERQAEQA-------KSELITNVSHDLRTPLTSIVGyVNLIHHDNYRDEvELRHYIQVIYDKVTRLNALMNDLFEYTR 223
Cdd:PRK11091 266 ITERKRYQDAlekasrdKTTFISTISHELRTPLNGIVG-LSRILLDTELTA-EQRKYLKTIHVSAITLGNIFNDIIDMDK 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 224 VQNKELSLYSVPIDIVELLGQLTVQFRIQLQEA----NIDCRPFFPSKklmVLADGDKLVRVFENLIINAIAYGNDGDYI 299
Cdd:PRK11091 344 MERRKLQLDNQPIDFTDFLADLENLSGLQAEQKglrfDLEPLLPLPHK---VITDGTRLRQILWNLISNAVKFTQQGGVT 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 300 DITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTG-GSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFT 377
Cdd:PRK11091 421 VRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEeGKGSCFT 500
|
...
gi 447166045 378 VKL 380
Cdd:PRK11091 501 LTI 503
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
282-382 |
6.50e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 84.18 E-value: 6.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 282 FENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELH 361
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|..
gi 447166045 362 KGTIEVYSD-DKKTTFTVKLQP 382
Cdd:cd16952 85 DARLLIASElGKGSRFTCLFPS 106
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
155-367 |
7.33e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 90.74 E-value: 7.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 155 RQAEQAKSELITNVSHDLRTPLTSI-VGYVNLIHHDNYrdeveLRHYIqvIYDkVTRLNALMNDLFEYTRvQNKELSLys 233
Cdd:PRK09467 223 KQLEDDRTLLMAGVSHDLRTPLTRIrLATEMMSEEDGY-----LAESI--NKD-IEECNAIIEQFIDYLR-TGQEMPM-- 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 234 VPIDIVELLG---------QLTVQFRIQLQEANIDCRPFfpSKKlmvladgdklvRVFENLIINAIAYGNDgdYIDITAY 304
Cdd:PRK09467 292 EMADLNALLGeviaaesgyEREIETALQPGPIEVPMNPI--AIK-----------RALANLVVNAARYGNG--WIKVSSG 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447166045 305 ESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNtgGSGLGLAIAKSIVELHKGTIEV 367
Cdd:PRK09467 357 TEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVEL 417
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
284-381 |
2.75e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 82.54 E-value: 2.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 284 NLIINAIAYGNDGdYIDITAY-----ESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIV 358
Cdd:cd16922 7 NLLGNAIKFTEEG-EVTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLV 85
|
90 100
....*....|....*....|....
gi 447166045 359 ELHKGTIEVYS-DDKKTTFTVKLQ 381
Cdd:cd16922 86 ELMGGDISVESePGQGSTFTFTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
169-380 |
1.05e-18 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 86.83 E-value: 1.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 169 SHDLRTPLTSIVGYVNLIHHDnyrdevELRHYIQVIYDKVTRLNAlmndlFEYTRVQNKELS--LYSVpIDIVELLGqlt 246
Cdd:COG3290 197 RHDFRNHLHTISGLLQLGEYD------EALEYIDEISEELQELID-----SLLSRIGNPVLAalLLGK-AARARERG--- 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 247 vqfrIQLqeaNIDCRPFFPSKKLmvlaDGDKLVRVFENLIINAI--AYGNDGD--YIDITAYESNNMIAIDITNYGQPIP 322
Cdd:COG3290 262 ----IDL---TIDIDSDLPDLPL----SDTDLVTILGNLLDNAIeaVEKLPEEerRVELSIRDDGDELVIEVEDSGPGIP 330
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 323 STDLPHIFERFYrveksrSTNTG-GSGLGLAIAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:COG3290 331 EELLEKIFERGF------STKLGeGRGLGLALVKQIVEKYGGTIEVESEEGEgTVFTVRL 384
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
121-369 |
7.46e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 85.34 E-value: 7.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 121 FNHKVSIVNHNYlEELASGVNQIVEQLKVSIDEERQA-------EQAKSELITNVSHDLRTPLTSIVGYVNLIHHD---- 189
Cdd:PRK11466 398 FRSNVHALNRHR-EQLAAQVKARTAELQELVIEHRQAraeaekaSQAKSAFLAAMSHEIRTPLYGILGTAQLLADNpaln 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 190 NYRDevelrhYIQVIYDKVTRLNALMNDLFEYTRVQ--NKELSLYSVPIDIVELLGQLtvqfrIQLQEANIDCRPF---- 263
Cdd:PRK11466 477 AQRD------DLRAITDSGESLLTILNDILDYSAIEagGKNVSVSDEPFEPRPLLEST-----LQLMSGRVKGRPIrlat 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 264 -----FPSkklMVLADGDKLVRVFENLIINAIAYGNDGdYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEK 338
Cdd:PRK11466 546 diaddLPT---ALMGDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSG 621
|
250 260 270
....*....|....*....|....*....|.
gi 447166045 339 SRstntGGSGLGLAIAKSIVELHKGTIEVYS 369
Cdd:PRK11466 622 KR----GGTGLGLTISSRLAQAMGGELSATS 648
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-366 |
1.72e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 74.41 E-value: 1.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGndGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRStnTGGSGLGLAIAKSI 357
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
....*....
gi 447166045 358 VELHKGTIE 366
Cdd:cd16950 77 SDAHGGSLT 85
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
158-223 |
2.56e-15 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 69.93 E-value: 2.56e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447166045 158 EQAKSELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEvELRHYIQVIYDKVTRLNALMNDLFEYTR 223
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDE-EQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
274-367 |
5.41e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 70.60 E-value: 5.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 274 DGDKLVRVFENLIINAIAYGNDGDYID-ITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLA 352
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRcILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90
....*....|....*
gi 447166045 353 IAKSIVELHKGTIEV 367
Cdd:cd16925 81 IVKEFVELHGGTVTV 95
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
74-369 |
5.63e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 76.26 E-value: 5.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 74 MMIVSylFLFSIFSSYLYIFYRHERKLyyetciKKMIEEIRYIANGNFNHKVSIVNHNYLEELA-------SGVNQIVEQ 146
Cdd:COG4192 331 IALLS--LLLAVLINYFYVRRRLVKRL------NALSDAMAAIAAGDLDVPIPVDGNDEIGRIArllrvfrDQAIEKTQE 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 147 LKVSIDEERQAE----QAKSELI------------TNVSHDLRTPLTSIVGYVNLIH----HDNYRdevELRHYIQVIYD 206
Cdd:COG4192 403 LETEIEERKRIEknlrQTQDELIqaakmavvgqtmTSLAHELNQPLNAMSMYLFSAKkaleQENYA---QLPTSLDKIEG 479
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 207 KVTRLNALMNDLFEYTRVQNKELslysVPIDIVELLGQ--LTVQFRIQLQEANIDCRPFfpskkLMVLADGDKLVRVFEN 284
Cdd:COG4192 480 LIERMDKIIKSLRQFSRKSDTPL----QPVDLRQVIEQawELVESRAKPQQITLHIPDD-----LMVQGDQVLLEQVLVN 550
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 285 LIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDlpHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGT 364
Cdd:COG4192 551 LLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFT------TTKEVGLGLGLSICRSIMQQFGGD 622
|
....*
gi 447166045 365 IEVYS 369
Cdd:COG4192 623 LYLAS 627
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
274-365 |
1.53e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 69.03 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 274 DGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNtGGSGLGLAI 353
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90
....*....|..
gi 447166045 354 AKSIVELHKGTI 365
Cdd:cd16975 80 AKNLVEKHGGSL 91
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-365 |
2.02e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 68.75 E-value: 2.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYG-NDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYrVEKSRSTNTG-GSGLGLAIAK 355
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90
....*....|
gi 447166045 356 SIVELHKGTI 365
Cdd:cd16953 80 QIIEAHGGIS 89
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-380 |
2.83e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 68.22 E-value: 2.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRStntgGSGLGLAIAKSI 357
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYRI 79
|
90 100
....*....|....*....|....
gi 447166045 358 VELHKGTIEVYS-DDKKTTFTVKL 380
Cdd:cd16943 80 IQKHGGTIRVASvPGGGTRFTIIL 103
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
168-382 |
2.11e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 71.63 E-value: 2.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 168 VSHDLRTPLTSIVGYVNlIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKElslySVPIDIVELLGQLTV 247
Cdd:PRK13837 457 IAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERN----TKPFDLSELVTEIAP 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 248 QFRIQLQE-ANIDCRpfFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESN---------------NMIA 311
Cdd:PRK13837 532 LLRVSLPPgVELDFD--QDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrapkvlshgvlppgRYVL 609
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447166045 312 IDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTFTVKLQP 382
Cdd:PRK13837 610 LRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTvGRGTRFDVYLPP 675
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
275-367 |
2.21e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 65.89 E-value: 2.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 275 GDKLVrVFE---NLIINAIAYGNDGDYIDITAyESNNMIAIDITNYGQPIPSTDLPHIFERFYRvekSRSTNTGGSGLGL 351
Cdd:cd16940 9 GDALL-LFLllrNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYR---SDGQNYGGSGLGL 83
|
90
....*....|....*.
gi 447166045 352 AIAKSIVELHKGTIEV 367
Cdd:cd16940 84 SIVKRIVELHGGQIFL 99
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
143-380 |
2.55e-13 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 71.69 E-value: 2.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 143 IVEQLKVSIDEERQAEQAKSELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRHyIQVIYDKVTRLNALMNDLFEYT 222
Cdd:PRK09959 694 LIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEA-ISLAYATGQSLLGLIGEILDVD 772
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 223 RVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANI--DCRPFFPSKKLmVLADGDKLVRVFENLIINAIAYGNDGDYID 300
Cdd:PRK09959 773 KIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIalSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKFTTEGAVKI 851
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 301 ITAY----ESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNtgGSGLGLAIAKSIVELHKGTIEVYSDDK-KTT 375
Cdd:PRK09959 852 TTSLghidDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGiGTT 929
|
....*
gi 447166045 376 FTVKL 380
Cdd:PRK09959 930 FTITI 934
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
133-380 |
4.51e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 69.72 E-value: 4.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 133 LEELAsgvnQIVEQLKVSIDEERQAEQ-AKSELITNVSHDLRTPLTSIVGYVNLIhhDNYRDEVELRHYIQVIYDKVTRL 211
Cdd:PRK11073 105 LLEMA----PMDNQRRLSQEQLQHAQQvAARDLVRGLAHEIKNPLGGLRGAAQLL--SKALPDPALTEYTKVIIEQADRL 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 212 NALMNDLFEYTRV-QNKELSLYSVPIDIVELLgQLTVQFRIQLQEaniDCRPFFPSkklmVLADGDKLVRVFENLIINAI 290
Cdd:PRK11073 179 RNLVDRLLGPQRPgTHVTESIHKVAERVVQLV-SLELPDNVRLIR---DYDPSLPE----LAHDPDQIEQVLLNIVRNAL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 291 -AYGNDGDYIDI---TAYESN------NMIA-IDITNYGQPIPstdlPHIFER-FYRVEKSRStntGGSGLGLAIAKSIV 358
Cdd:PRK11073 251 qALGPEGGTITLrtrTAFQLTlhgeryRLAArIDIEDNGPGIP----PHLQDTlFYPMVSGRE---GGTGLGLSIARNLI 323
|
250 260
....*....|....*....|..
gi 447166045 359 ELHKGTIEVYSDDKKTTFTVKL 380
Cdd:PRK11073 324 DQHSGKIEFTSWPGHTEFSVYL 345
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
160-226 |
5.17e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 63.38 E-value: 5.17e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447166045 160 AKSELITNVSHDLRTPLTSIVGYVNLIhhDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQN 226
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELL--RDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-367 |
2.86e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 62.45 E-value: 2.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDgdYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSI 357
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90
....*....|
gi 447166045 358 VELHKGTIEV 367
Cdd:cd16939 79 ALWHGGHVEC 88
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-378 |
1.55e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 60.76 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTgGSGLGLAIAKSI 357
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYLVKKL 84
|
90 100
....*....|....*....|....
gi 447166045 358 VE--LHKgtIEVYSDDKK-TTFTV 378
Cdd:cd16948 85 CDklGHK--IDVESEVGEgTTFTI 106
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
160-226 |
6.43e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.58 E-value: 6.43e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447166045 160 AKSELITNVSHDLRTPLTSIVGYVNLIhhDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQN 226
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELL--LDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-367 |
9.65e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 58.24 E-value: 9.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTgGSGLGLAIAKSI 357
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEV 83
|
90
....*....|
gi 447166045 358 VELHKGTIEV 367
Cdd:cd16945 84 AQLHGGRITL 93
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
156-369 |
1.53e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 63.07 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 156 QAEQAKSELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVElrhyiqviydkvtRLNALMN-----------DLFEYTRV 224
Cdd:PRK10841 442 QASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVD-------------RLVTAMNnssslllkiisDILDFSKI 508
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 225 QNKELSLYSVPIDIVELLGQLT-------VQFRIQLQeanidCrpfFPSKKLMVLADGD--KLVRVFENLIINAIAYGND 295
Cdd:PRK10841 509 ESEQLKIEPREFSPREVINHITanylplvVKKRLGLY-----C---FIEPDVPVALNGDpmRLQQVISNLLSNAIKFTDT 580
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447166045 296 GDYIdITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYS 369
Cdd:PRK10841 581 GCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDS 653
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
170-361 |
2.51e-10 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 61.59 E-value: 2.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 170 HDLRTPLTS--IVGYVNLIHHDnyrDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTV 247
Cdd:PRK10337 246 HELRSPLAAlkVQTEVAQLSDD---DPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVM 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 248 QFRIQLQEANIDCRPFFPSKK--------LMVLadgdkLVRvfeNLIINAIAYGNDGDYIDITAYESnnmiAIDITNYGQ 319
Cdd:PRK10337 323 DIYHTAQQAGIDVRLTLNAHPvirtgqplLLSL-----LVR---NLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGP 390
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 447166045 320 PIPSTDLPHIFERFYR---VEKSrstntgGSGLGLAIAKSIVELH 361
Cdd:PRK10337 391 GVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLH 429
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-381 |
2.80e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 56.95 E-value: 2.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAIAYGNDGD--YIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEkSRStNTGGSGLGLAIAK 355
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SRE-EYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 447166045 356 SIVELHKGTIEVYSD-DKKTTFTVKLQ 381
Cdd:cd16921 79 KIIERHGGRIWLESEpGEGTTFYFTLP 105
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-380 |
3.39e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 57.03 E-value: 3.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAI--AYGNDGDYIDITAYESNNMIA---------IDITNYGQPIPSTDLPHIFERFYrveksrSTNTGG 346
Cdd:cd16918 1 LIQVFLNLVRNAAqaLAGSGGEIILRTRTQRQVTLGhprhrlalrVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....
gi 447166045 347 SGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKL 380
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSL 108
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
156-381 |
4.88e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 58.32 E-value: 4.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 156 QAEQAKSELITNVSHDLRTPLTSIVGYVNLIH----HDNYRDevelrhYIQVIYDKVTRLNALMNDLFEYTRVQNKELSL 231
Cdd:PRK11107 288 EAARIKSEFLANMSHELRTPLNGVIGFTRQTLktplTPTQRD------YLQTIERSANNLLAIINDILDFSKLEAGKLVL 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 232 YSVPIDIVELLGQLtvqfrIQLQ---------EANIDCRPFFPSKklmVLADGDKLVRVFENLIINAIAYGNDGDyIDI- 301
Cdd:PRK11107 362 ENIPFSLRETLDEV-----VTLLahsahekglELTLNIDPDVPDN---VIGDPLRLQQIITNLVGNAIKFTESGN-IDIl 432
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 302 ---TAYESNNM-IAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSD-DKKTTF 376
Cdd:PRK11107 433 velRALSNTKVqLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQpNRGSTF 512
|
....*..
gi 447166045 377 --TVKLQ 381
Cdd:PRK11107 513 wfHLPLD 519
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
278-384 |
2.41e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 55.69 E-value: 2.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAI--AYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAK 355
Cdd:PRK11086 434 LITILGNLIENALeaVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVK 507
|
90 100 110
....*....|....*....|....*....|
gi 447166045 356 SIVELHKGTIEVYSDDKK-TTFTVKLqPYK 384
Cdd:PRK11086 508 QSVENLGGSIAVESEPGVgTQFFVQI-PWD 536
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
141-363 |
2.54e-08 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 54.97 E-value: 2.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 141 NQIVEQLKVSIDEERQaeqakseLITNVSHDLRTPLTSIvgyvnlihhdnyRDEVEL---RHYIQVIyDKVTRLNALM-- 215
Cdd:PRK10755 124 NQLVSRLTSTLDQERL-------FTADVAHELRTPLAGI------------RLHLELlekQHHIDVA-PLIARLDQMMht 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 216 -NDLFEYTRVQNKELSLYSVPIDIV------------ELLGQLTVQFRIQLQEANIDCRpffpskklmvladGDK-LVRV 281
Cdd:PRK10755 184 vEQLLQLARAGQSFSSGHYQTVKLLedvilpsqdelsEMLEQRQQTLLLPESAADITVQ-------------GDAtLLRL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 282 -FENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEksrsTNTGGSGLGLAIAKSIVEL 360
Cdd:PRK10755 251 lLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQL 326
|
...
gi 447166045 361 HKG 363
Cdd:PRK10755 327 HHG 329
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
6-380 |
3.58e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 55.02 E-value: 3.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 6 FDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIESSLTLSELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSI 85
Cdd:COG2972 90 LLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLL 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 86 FSSYLYIFYRHerklyYETCIKKMIEEIRYIANGNFnHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQAEQAK--SE 163
Cdd:COG2972 170 ALLLSYLLSRS-----ITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKkeAE 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 164 LITNVS----HDLRTPLTSIVGYVNLihhdnyRDEVELRHYIQviydkvtrlnaLMNDLFEYTRVQNKELSLYSVPIDIV 239
Cdd:COG2972 244 LKALQAqinpHFLFNTLNSIRWLAEL------EDPEEAEEMLE-----------ALSKLLRYSLSKGDELVTLEEELELI 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 240 E--LLGQLT-----VQFRIQLQEANIDCRpfFPskKLMVLAdgdkLVrvfENLIINAIAYGNDGDYIDITAYESNNMIAI 312
Cdd:COG2972 307 KsyLEIQKLrfgdrLEVEIEIDEELLDLL--IP--KLILQP----LV---ENAIEHGIEPKEGGGTIRISIRKEGDRLVI 375
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447166045 313 DITNYGQPIPSTDLPHIFERFyrveksrSTNTGGSGLGLAIAKSIVELH---KGTIEVYS-DDKKTTFTVKL 380
Cdd:COG2972 376 TVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYygeEYGLEIESePGEGTTVTIRI 440
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
281-380 |
1.61e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 48.93 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 281 VFENLIINAI----AYGNDGDYIDI-TAYESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAK 355
Cdd:cd16920 4 VLINLVRNGIeamsEGGCERRELTIrTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICR 77
|
90 100
....*....|....*....|....*.
gi 447166045 356 SIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:cd16920 78 SIIEAHGGRLSVESPAGGgATFQFTL 103
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
266-369 |
5.05e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 48.40 E-value: 5.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 266 SKKLMVLADGDKLVRVFENLIINAIAYGNDgdYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRStntg 345
Cdd:cd16954 26 SPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP---- 99
|
90 100
....*....|....*....|....
gi 447166045 346 GSGLGLAIAKSIVELHKGTIEVYS 369
Cdd:cd16954 100 GQGLGLAIAKEIVEQYGGELSLSD 123
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-380 |
6.60e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 47.28 E-value: 6.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAI----AYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYrveksrSTN-TGGSGLGLA 352
Cdd:cd16915 1 LITIVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV------STKgQGERGIGLA 74
|
90 100
....*....|....*....|....*....
gi 447166045 353 IAKSIVELHKGTIEVYSDDKK-TTFTVKL 380
Cdd:cd16915 75 LVRQSVERLGGSITVESEPGGgTTFSIRI 103
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
278-380 |
2.52e-06 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 45.67 E-value: 2.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAI---AYGNDGDYIDITAYESNNMIAIDITNY--GQPIPSTDLPhiferfyrvekSRSTNTGGSGLGLA 352
Cdd:pfam14501 6 LCVIFGNLLDNAIeacSKIDDNRFIRLKIREKQNFLIIRIENTyeGELKFEGKLP-----------STKTKGDGHGIGLK 74
|
90 100
....*....|....*....|....*...
gi 447166045 353 IAKSIVELHKGTIEVYSDDKktTFTVKL 380
Cdd:pfam14501 75 SIRRIVKKYGGNLSTEIENG--IFTLSI 100
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
106-367 |
1.02e-05 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 47.42 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 106 IKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQAEQAKSELITNVSHDLRTPLTSIVgyVNL 185
Cdd:COG2770 240 LRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALL--LLL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 186 IHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPFFP 265
Cdd:COG2770 318 LALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAA 397
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 266 SKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRSTNTG 345
Cdd:COG2770 398 LAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAA 477
|
250 260
....*....|....*....|..
gi 447166045 346 GSGLGLAIAKSIVELHKGTIEV 367
Cdd:COG2770 478 LLLLAALGALELLLLEEEEEAG 499
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-367 |
5.09e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 42.06 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 278 LVRVFENLIINAI--AYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYR---VEKsrstntgGSGLGLA 352
Cdd:cd16976 1 IQQVLMNLLQNALdaMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTtkpVGK-------GTGLGLS 73
|
90
....*....|....*
gi 447166045 353 IAKSIVELHKGTIEV 367
Cdd:cd16976 74 ISYGIVEEHGGRLSV 88
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
266-367 |
5.78e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 45.01 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 266 SKKLMVLADGDKLVRVFENLIINAIAYGNDgdYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRStntg 345
Cdd:PRK10815 367 SPEITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP---- 440
|
90 100
....*....|....*....|..
gi 447166045 346 GSGLGLAIAKSIVELHKGTIEV 367
Cdd:PRK10815 441 GQGLGLSVAREITEQYEGKISA 462
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
285-378 |
8.87e-05 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 41.89 E-value: 8.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 285 LIINAIAYGNDGD---YIDITAYESNNMIAIDITNYGQPIPSTDLPHiferfyRVEKSRSTNTGGSGLGLAIAKSIVElh 361
Cdd:pfam13581 39 ACTNAVEHAYREGpegPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP------PDLEEPDEDRKEGGRGLALIRGLMD-- 110
|
90
....*....|....*..
gi 447166045 362 kgTIEVYSDDKKTTFTV 378
Cdd:pfam13581 111 --DVEYTRGGEGNTVRM 125
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
106-367 |
1.20e-04 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 44.10 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 106 IKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDE---ERQAEQAKSELITNVSHDLRTPLTSIVGY 182
Cdd:COG3850 146 LRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAEleeEEELEAELELLALLDELLLLAALLLLLAL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 183 VNLIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYTRVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRP 262
Cdd:COG3850 226 LLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEAL 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 263 FFPSKKLMVLADGDKLVRVFENLIINAIAYGNDGDYIDITAYESNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSRST 342
Cdd:COG3850 306 LLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEA 385
|
250 260
....*....|....*....|....*
gi 447166045 343 NTGGSGLGLAIAKSIVELHKGTIEV 367
Cdd:COG3850 386 LGLLAEASEGAAGQGAGLVDVEGGV 410
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
310-367 |
1.26e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 40.98 E-value: 1.26e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 447166045 310 IAIDITNYGQPIPSTDLPHIFERFYrveksrSTNTGGSGLGLAIAKSIVELHKGTIEV 367
Cdd:cd16944 42 IVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTGLGLAIVKKIMEEHGGRISL 93
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-380 |
3.95e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 37.17 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 248 QFRIQLQEANIDCRPFFPSKKLMVLADGDkLVRVFENLIINAI---AYGNDGD-YIDITAYESNNMIAIDITNYGQPips 323
Cdd:cd16935 8 EKLELAREKGIEFTIEIDIPILLPISPLD-LCIIFGNLLDNAIeacAKIDKENrFIHLKIRQKKGFLIISIENSYEG--- 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 447166045 324 tDLPHIFERFYrveKSRSTNtgGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKL 380
Cdd:cd16935 84 -ELKKKNGLFL---STKKDK--NHGIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
106-172 |
7.91e-03 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 38.08 E-value: 7.91e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447166045 106 IKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQ-AEQ--AKSELITNVSHDL 172
Cdd:COG0840 210 LRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVREsAEQvaSASEELAASAEEL 279
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
106-147 |
9.40e-03 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 33.96 E-value: 9.40e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 447166045 106 IKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQL 147
Cdd:cd06225 4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| |
