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Conserved domains on  [gi|447173001|ref|WP_001250257|]
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MULTISPECIES: response regulator transcription factor [Bacillus]

Protein Classification

response regulator transcription factor( domain architecture ID 11433066)

OmpR family response regulator transcription factor with a signal receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding domain that may be part of a two-component regulatory system

CATH:  3.40.50.2300
Gene Ontology:  GO:0006355|GO:0003677|GO:0000160|GO:0000156
PubMed:  11226872|10966457|31100988
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-215 1.21e-56

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 178.61  E-value: 1.21e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVT 79
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRaRPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSncnQQNEITFyqfkDLFVDASSNIVKKGGKNLSLTKREYD 159
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR---AAEVLRV----GDLLDLAAREVTRDGEPVELTPKEFR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447173001 160 LLVFLIKNKNTILSREMLLNQVWGHnVVVNPNVVDLYIGYVRKKLkcekKNRYIQT 215
Cdd:COG0745  154 LLELLMRNPGRVVSREQLLEEVWGY-DYGDDRTVDVHISRLRKKL----EDDLIET 204
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-215 1.21e-56

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 178.61  E-value: 1.21e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVT 79
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRaRPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSncnQQNEITFyqfkDLFVDASSNIVKKGGKNLSLTKREYD 159
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR---AAEVLRV----GDLLDLAAREVTRDGEPVELTPKEFR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447173001 160 LLVFLIKNKNTILSREMLLNQVWGHnVVVNPNVVDLYIGYVRKKLkcekKNRYIQT 215
Cdd:COG0745  154 LLELLMRNPGRVVSREQLLEEVWGY-DYGDDRTVDVHISRLRKKL----EDDLIET 204
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 2-222 1.02e-51

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 166.74  E-value: 1.02e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001    2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIV 78
Cdd:TIGR02154   3 RRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPETraiPIIML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITfyQFKDLFVDASSNIVKKGGKNLSLTKREY 158
Cdd:TIGR02154  83 TARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRPQLSDEVI--EVGDLSLDPVAHRVFRGGQPLSLGPTEF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001  159 DLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGYS 222
Cdd:TIGR02154 161 RLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLEDPVQTVRGAGYR 224
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
4-221 3.38e-41

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 139.62  E-value: 3.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAESGVPIIMLTAKSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITfyqFKDLFVDASSNIVKKGGKNLSLTKREYDLLVF 163
Cdd:NF040689  81 TVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEVLR---IGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVA 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447173001 164 LIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKN-RYIQTIHGRGY 221
Cdd:NF040689 158 LARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIERDPENpEIVVTVRGVGY 216
resp_reg_YycF NF040534
response regulator YycF;
2-221 6.80e-38

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 131.38  E-value: 6.80e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDN 81
Cdd:NF040534   1 KKILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  82 ISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR----SNCNQQNEITFYQFKDLFVDASSNIVKKGGKNLSLTKRE 157
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRhqqqNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIELTHRE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447173001 158 YDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKN-RYIQTIHGRGY 221
Cdd:NF040534 161 FELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHpEWIVTRRGVGY 225
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
2-221 5.50e-36

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 126.76  E-value: 5.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIV 78
Cdd:PRK10161   3 RRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTrdiPVVML 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITfyQFKDLFVDASSNIVKKGGKNLSLTKREY 158
Cdd:PRK10161  83 TARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVI--EMQGLSLDPTSHRVMAGEEPLEMGPTEF 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447173001 159 DLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGY 221
Cdd:PRK10161 161 KLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGY 223
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-116 5.53e-26

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 97.32  E-value: 5.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR---LVKMTPVIIV 78
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKrdeMTRDIPIIML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447173001  79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
148-223 3.61e-22

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 86.03  E-value: 3.61e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447173001  148 GKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKL-KCEKKNRYIQTIHGRGYSM 223
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLeDDPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 148-221 1.59e-21

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 84.53  E-value: 1.59e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001   148 GKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGY 221
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGDPRLIETVRGVGY 74
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-215 1.21e-56

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 178.61  E-value: 1.21e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVT 79
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRaRPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSncnQQNEITFyqfkDLFVDASSNIVKKGGKNLSLTKREYD 159
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR---AAEVLRV----GDLLDLAAREVTRDGEPVELTPKEFR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447173001 160 LLVFLIKNKNTILSREMLLNQVWGHnVVVNPNVVDLYIGYVRKKLkcekKNRYIQT 215
Cdd:COG0745  154 LLELLMRNPGRVVSREQLLEEVWGY-DYGDDRTVDVHISRLRKKL----EDDLIET 204
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 2-222 1.02e-51

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 166.74  E-value: 1.02e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001    2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIV 78
Cdd:TIGR02154   3 RRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPETraiPIIML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITfyQFKDLFVDASSNIVKKGGKNLSLTKREY 158
Cdd:TIGR02154  83 TARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRPQLSDEVI--EVGDLSLDPVAHRVFRGGQPLSLGPTEF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001  159 DLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGYS 222
Cdd:TIGR02154 161 RLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLEDPVQTVRGAGYR 224
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
4-221 3.38e-41

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 139.62  E-value: 3.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAESGVPIIMLTAKSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITfyqFKDLFVDASSNIVKKGGKNLSLTKREYDLLVF 163
Cdd:NF040689  81 TVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEVLR---IGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVA 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447173001 164 LIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKN-RYIQTIHGRGY 221
Cdd:NF040689 158 LARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIERDPENpEIVVTVRGVGY 216
resp_reg_YycF NF040534
response regulator YycF;
2-221 6.80e-38

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 131.38  E-value: 6.80e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDN 81
Cdd:NF040534   1 KKILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  82 ISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR----SNCNQQNEITFYQFKDLFVDASSNIVKKGGKNLSLTKRE 157
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRhqqqNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIELTHRE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447173001 158 YDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKN-RYIQTIHGRGY 221
Cdd:NF040534 161 FELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHpEWIVTRRGVGY 225
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
2-221 5.50e-36

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 126.76  E-value: 5.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIV 78
Cdd:PRK10161   3 RRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTrdiPVVML 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITfyQFKDLFVDASSNIVKKGGKNLSLTKREY 158
Cdd:PRK10161  83 TARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVI--EMQGLSLDPTSHRVMAGEEPLEMGPTEF 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447173001 159 DLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGY 221
Cdd:PRK10161 161 KLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGY 223
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 3-221 3.94e-35

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 124.27  E-value: 3.94e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLV-KMTPVIIVTDN 81
Cdd:PRK09836   2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSAnKGMPILLLTAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  82 ISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNcnqqNEITFYQFK--DLFVDASSNIVKKGGKNLSLTKREYD 159
Cdd:PRK09836  82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGA----AVIIESQFQvaDLMVDLVSRKVTRSGTRITLTSKEFT 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447173001 160 LLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGY 221
Cdd:PRK09836 158 LLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDNDFEPKLIQTVRGVGY 219
cztR_silR_copR TIGR01387
heavy metal response regulator; Members of this family contain a response regulator receiver ...
 4-223 5.28e-35

heavy metal response regulator; Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions]


Pssm-ID: 130454 [Multi-domain]  Cd Length: 218  Bit Score: 123.76  E-value: 5.28e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001    4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLV-KMTPVIIVTDNI 82
Cdd:TIGR01387   1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKDDYDLIILDVMLPGMDGWQILQTLRRSgKQTPVLFLTARD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQneiTFYQFKDLFVDASSNIVKKGGKNLSLTKREYDLLV 162
Cdd:TIGR01387  81 SVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRSHSLNS---TVLEIADLRMDSVRHRVSRGNIRITLTRKEFQLLW 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447173001  163 FLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGYSM 223
Cdd:TIGR01387 158 LLMRRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRAKVDDPFEEKLIHTIRGMGYVL 218
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-224 1.51e-34

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 122.99  E-value: 1.51e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIyEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTD 80
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLL-DDSIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITFYQFKDLFVDASSniVKKG-------GKNLSL 153
Cdd:PRK10955  80 RGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDALS--LNPGrqeasfdGQTLEL 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447173001 154 TKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNR-YIQTIHGRGYSMV 224
Cdd:PRK10955 158 TGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHpWFKTLRGRGYLMV 229
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-224 4.29e-33

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 118.85  E-value: 4.29e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKkIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTD 80
Cdd:PRK11517   1 MKILLIEDNQRTQEW-VTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQqneiTFYQFKDLFVDASSNIVKKGGKNLSLTKREYDL 160
Cdd:PRK11517  80 RDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALN----STLEISGLRMDSVSQSVSRDNISITLTRKEFQL 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001 161 LVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGYSMV 224
Cdd:PRK11517 156 LWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDPFPEKLIATIRGMGYSFV 219
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 1-221 5.65e-33

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 118.75  E-value: 5.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTD 80
Cdd:PRK10529   1 MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEiTFYQFKDLFVDASSNIVKKGGKNLSLTKREYDL 160
Cdd:PRK10529  81 RSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATPAPD-PLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRL 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447173001 161 LVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCE-KKNRYIQTIHGRGY 221
Cdd:PRK10529 160 LAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDpARPRHFITETGIGY 221
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-222 9.82e-30

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 110.44  E-value: 9.82e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEG----HFILKLhnenEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPV 75
Cdd:PRK11083   3 QPTILLVEDEQAIADTLVYALQSEGftveWFERGL----PALDKLRQQPPDLVILDVGLPDISGFELCRQLLaFHPALPV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  76 IIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSN--CNQQNEITFYQFKdlfVDASSNIVKKGGKNLSL 153
Cdd:PRK11083  79 IFLTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKkfAAPSPVIRIGHFE---LDEPAARISYFGTPLTL 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001 154 TKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRY-IQTIHGRGYS 222
Cdd:PRK11083 156 TRYEFLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLRAINPDLSpINTHRGMGYS 225
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-221 3.03e-29

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 109.39  E-value: 3.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNI 82
Cdd:PRK10710  12 RILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRsnCNQQNEITFYQFK-DLFVDASSNIVKKGGKNLSLTKREYDLL 161
Cdd:PRK10710  92 EEIDRLLGLEIGADDYICKPYSPREVVARVKTILRR--CKPQRELQQQDAEsPLIIDESRFQASWRGKMLDLTPAEFRLL 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447173001 162 VFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLK-CEKKNRYIQTIHGRGY 221
Cdd:PRK10710 170 KTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLEsLDAEQSFIRAVYGVGY 230
PRK10336 PRK10336
two-component system response regulator QseB;
1-223 8.69e-29

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 107.67  E-value: 8.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRqVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLV-KMTPVIIVT 79
Cdd:PRK10336   1 MR-ILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKgQREPVLILT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEItfyQFKDLFVDASSNIVKKGGKNLSLTKREYD 159
Cdd:PRK10336  80 ARDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNEL---RHGNVMLDPGKRIATLAGEPLTLKPKEFA 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001 160 LLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEkknrYIQTIHGRGYSM 223
Cdd:PRK10336 157 LLELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSD----FIRTVHGIGYTL 216
orf27 CHL00148
Ycf27; Reviewed
 3-221 1.24e-28

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 107.88  E-value: 1.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNI 82
Cdd:CHL00148   8 KILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVPIIMLTALG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQN----EITFYQFKDLFVDASSNIVKKGGKNLSLTKREY 158
Cdd:CHL00148  88 DVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSFSskipNSSIIRIGFLKIDLNKKQVYKNNERIRLTGMEF 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447173001 159 DLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNV--VDLYIGYVRKKLKCEKKN-RYIQTIHGRGY 221
Cdd:CHL00148 168 SLLELLISKSGEIFSRATILKEVWGYTPERHIDTrvVDVHISRLRAKLEDDPSNpDLILTARGTGY 233
PRK10643 PRK10643
two-component system response regulator PmrA;
3-225 9.55e-28

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 105.12  E-value: 9.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT-PVIIVTDN 81
Cdd:PRK10643   2 KILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTlPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  82 ISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEItfyQFKDLFVDASSNIVKKGGKNLSLTKREYDLL 161
Cdd:PRK10643  82 DTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQGENEL---QVGNLTLNLGRQQVWLDGQELILTPKEFALL 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001 162 VFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLkceKKNRyIQTIHGRGYSMVE 225
Cdd:PRK10643 159 SRLMLKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRDKV---GKDR-IRTVRGFGYMLVA 218
ompR PRK09468
osmolarity response regulator; Provisional
 21-224 1.65e-26

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 101.97  E-value: 1.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  21 LTQEGhFILKLHNENEGLNIIYEQD-WDIIILDW-----DSLSIsgpeiCRQIRLVK-MTPVIIVTDNISSKDCVAGLQA 93
Cdd:PRK09468  25 LTEQG-FQVRSAANAEQMDRLLTREsFHLMVLDLmlpgeDGLSI-----CRRLRSQNnPTPIIMLTAKGEEVDRIVGLEI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  94 GADDYIRKPFAKEELVARVQAILRRSN-------CNQQNEITFYQFKdlfVDASSNIVKKGGKNLSLTKREYDLLVFLIK 166
Cdd:PRK09468  99 GADDYLPKPFNPRELLARIRAVLRRQApelpgapSQEEEVIAFGKFK---LNLGTRELFRGDEPMPLTTGEFAVLKALVS 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 447173001 167 NKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKN-RYIQTIHGRGYSMV 224
Cdd:PRK09468 176 HPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEEDPAHpRYIQTVWGLGYVFV 234
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-116 5.53e-26

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 97.32  E-value: 5.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR---LVKMTPVIIV 78
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKrdeMTRDIPIIML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447173001  79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-118 2.56e-25

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 95.57  E-value: 2.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAKDS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:cd17614   81 EVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 135-223 4.78e-25

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 94.08  E-value: 4.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001 135 LFVDASSNIVKKGGKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQ 214
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPEPRLIK 80


                 ....*....
gi 447173001 215 TIHGRGYSM 223
Cdd:cd00383   81 TVRGVGYRL 89
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-117 7.04e-25

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 96.13  E-value: 7.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLV---KMTPVII 77
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADprtADIPIIF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 447173001  78 VTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILR 117
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVAR 120
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-117 8.85e-25

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 94.09  E-value: 8.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI 82
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQsLPVLILTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILR 117
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
PRK10816 PRK10816
two-component system response regulator PhoP;
1-221 1.37e-24

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 96.73  E-value: 1.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRqVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT-PVIIVT 79
Cdd:PRK10816   1 MR-VLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSlPILVLT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITFYQFKdlfVDASSNIVKKGGKNLSLTKREYD 159
Cdd:PRK10816  80 ARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQ---VDLSRRELSINDEVIKLTAFEYT 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447173001 160 LLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGY 221
Cdd:PRK10816 157 IMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGY 218
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-119 3.46e-24

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 92.73  E-value: 3.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVTDNI 82
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRsEGRATPVLILTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRS 119
Cdd:cd19934   81 SWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRRA 117
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-117 9.44e-24

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 91.57  E-value: 9.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   5 LVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR---LVKMTPVIIVTDN 81
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRsdpKTSSIPIIMLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447173001  82 ISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILR 117
Cdd:cd19937   81 GEEFDKVLGLELGADDYITKPFSPRELLARVKAVLR 116
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-118 1.06e-23

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 91.13  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   5 LVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVK-MTPVIIVTDNIS 83
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGiETPVLLLTALDA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:cd17625   81 VEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
PRK10766 PRK10766
two-component system response regulator TorR;
4-218 1.72e-23

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 93.56  E-value: 1.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:PRK10766   5 ILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVTGRTD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEIT------FYQFKDLFVDASSNIVKKGGKNLSLTKRE 157
Cdd:PRK10766  85 SIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRISLARQAQPHaqeednCYRFAGYCLNVSRRTLERNGEPIKLTKAE 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447173001 158 YDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEkknrYIQTIHG 218
Cdd:PRK10766 165 YELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKLNPD----LFVTQHG 221
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-118 2.26e-23

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 90.52  E-value: 2.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLV-KMTPVIIVTDNI 82
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAgNDLPILVLTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:cd17627   81 SVSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
148-223 3.61e-22

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 86.03  E-value: 3.61e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447173001  148 GKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKL-KCEKKNRYIQTIHGRGYSM 223
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLeDDPRDPRLIKTVRGVGYRL 77
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-116 3.63e-22

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 87.46  E-value: 3.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI 82
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVkTPILILSGLA 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-118 4.51e-22

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 86.98  E-value: 4.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLMLTARGD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:cd17623   81 DIDRILGLELGADDYLPKPFNPRELVARIRAILRR 115
PRK15479 PRK15479
transcriptional regulator TctD;
1-223 6.27e-22

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 89.78  E-value: 6.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLViKNERSLAKKIVSGLTQEGhFILKLhnENEGL---NIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT-PVI 76
Cdd:PRK15479   1 MRLLLA-EDNRELAHWLEKALVQNG-FAVDC--VFDGLaadHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTlPVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  77 IVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITFYQFkdLFVDASSNIVKkgGKNLSLTKR 156
Cdd:PRK15479  77 LLTARSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQLGEL--IFHDEGYFLLQ--GQPLALTPR 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447173001 157 EYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLkcEKKNRYIQTIHGRGYSM 223
Cdd:PRK15479 153 EQALLTVLMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKL--QGSDVRITTLRGLGYVL 217
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 148-221 1.59e-21

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 84.53  E-value: 1.59e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001   148 GKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKNRYIQTIHGRGY 221
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGDPRLIETVRGVGY 74
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-102 4.93e-21

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 84.00  E-value: 4.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   5 LVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDW---DslsISGPEICRQIR-LVKMTPVIIVTD 80
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVmlpG---MDGFEVCRRLReKGSDIPIIMLTA 77

                         90       100
                 ....*....|....*....|..
gi 447173001  81 NISSKDCVAGLQAGADDYIRKP 102
Cdd:cd17574   78 KDEEEDKVLGLELGADDYITKP 99
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 1-221 5.06e-21

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 87.56  E-value: 5.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVT- 79
Cdd:PRK13856   1 MKHVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILR-RSNCNQQNEITFYQFKDLFVDASS-NIVKKGGKNLSLTKRE 157
Cdd:PRK13856  81 DRLEEADKVVALELGATDFIAKPFGTREFLARIRVALRvRPNVVRTKDRRSFCFADWTLNLRQrRLISEAGGEVKLTAGE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447173001 158 YDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKN-RYIQTIHGRGY 221
Cdd:PRK13856 161 FNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRRKLEQDPANpQLIKTARGAGY 225
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 4-119 7.61e-21

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 83.94  E-value: 7.61e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI 82
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPdVPVLFLTAKD 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRS 119
Cdd:cd17615   82 SVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRRS 118
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 4-126 1.44e-20

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 85.99  E-value: 1.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVI---KNERSLAKKIvsgLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVII 77
Cdd:COG3437    9 VLIVdddPENLELLRQL---LRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTrdiPVIF 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 447173001  78 VTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNE 126
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELD 134
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 3-116 1.56e-20

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 83.29  E-value: 1.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNI 82
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTAKS 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17626   82 DTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 4-102 3.06e-20

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 81.72  E-value: 3.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVT--D 80
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRaAGKQTPVLMLTarD 80

                         90       100
                 ....*....|....*....|..
gi 447173001  81 NISskDCVAGLQAGADDYIRKP 102
Cdd:cd19935   81 SVE--DRVKGLDLGADDYLVKP 100
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-116 1.21e-19

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 80.88  E-value: 1.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNI 82
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVPIIMVTARV 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd19938   81 EEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-126 2.57e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 85.40  E-value: 2.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVT 79
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRaLDPDLPVILLT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNE 126
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENA 128
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-113 5.93e-19

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 78.73  E-value: 5.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001    4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPtTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 447173001   83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQ 113
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 4-118 6.15e-17

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 73.56  E-value: 6.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd19939    2 ILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVPILMLTARTE 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:cd19939   82 EMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-102 1.26e-16

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 72.26  E-value: 1.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   5 LVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVTDNIS 83
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLReLPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 447173001  84 SKDCVAGLQAGADDYIRKP 102
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
PRK11173 PRK11173
two-component response regulator; Provisional
 3-221 2.67e-16

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 75.05  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNE---RSLAKKIVSGltqEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVT 79
Cdd:PRK11173   5 HILIVEDElvtRNTLKSIFEA---EGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRS-NCNQQNE----ITFYQFKDLFVDASS-NIVKKGGKNLSL 153
Cdd:PRK11173  82 GRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTmNLGTVSEerrsVESYKFNGWELDINSrSLISPDGEQYKL 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447173001 154 TKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLYIGYVRKKLKCEKKN-RYIQTIHGRGY 221
Cdd:PRK11173 162 PRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTpEIIATIHGEGY 230
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
130-224 8.20e-16

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 70.32  E-value: 8.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001 130 YQFKDLFVDASSNIVKKGGKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNvvdLY--IGYVRKKLK-C 206
Cdd:COG3710    3 YRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNS---LTqaISRLRKALGdD 79

                         90
                 ....*....|....*...
gi 447173001 207 EKKNRYIQTIHGRGYSMV 224
Cdd:COG3710   80 GLEPRLIRTVPRRGYRLV 97
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 4-117 1.33e-15

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 70.10  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd17622    3 ILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLTALDS 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAILR 117
Cdd:cd17622   83 DIDHILGLELGADDYVVKPVEPAVLLARLRALLR 116
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-119 2.90e-15

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 69.49  E-value: 2.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR---LVKMTPVII 77
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRalpRLPDIPIIA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 447173001  78 VTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRS 119
Cdd:COG0784   85 LTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARA 126
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-126 3.04e-15

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 69.61  E-value: 3.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHF--ILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVII 77
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFevVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPdVDVIV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 447173001  78 VTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNE 126
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQ 131
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 4-102 1.51e-14

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 66.84  E-value: 1.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVPVIMVTAKDS 80

                         90
                 ....*....|....*....
gi 447173001  84 SKDCVAGLQAGADDYIRKP 102
Cdd:cd17621   81 EIDKVVGLELGADDYVTKP 99
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 4-102 5.63e-14

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 65.26  E-value: 5.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSAVPVIVLSARDE 80

                         90
                 ....*....|....*....
gi 447173001  84 SKDCVAGLQAGADDYIRKP 102
Cdd:cd17620   81 ESDKIAALDAGADDYLTKP 99
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 21-103 1.15e-13

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 64.44  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  21 LTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIVTDNISSKDCVAGLQAGADD 97
Cdd:cd17538   19 LSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETrhiPVIMITALDDREDRIRGLEAGADD 98


                 ....*.
gi 447173001  98 YIRKPF 103
Cdd:cd17538   99 FLSKPI 104
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 4-116 1.88e-13

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 64.65  E-value: 1.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRL---VKMTPVIIVTD 80
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSdpdLKDIPVILLTT 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17598   81 LSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-114 1.22e-12

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 62.08  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVT-DNI 82
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISgDRR 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQA 114
Cdd:cd17594   82 DEIDRVVGLELGADDYLAKPFGLRELLARVRA 113
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 4-113 3.66e-12

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 60.86  E-value: 3.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd17619    3 ILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIILVTGRDD 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQ 113
Cdd:cd17619   83 EVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 41-221 4.41e-11

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 60.42  E-value: 4.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  41 IYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSN 120
Cdd:PRK10701  41 ILREQPDLVLLDIMLPGKDGMTICRDLRPKWQGPIVLLTSLDSDMNHILALEMGACDYILKTTPPAVLLARLRLHLRQNE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001 121 CNQQNE------ITFY---QFKDLFVDASSNIVKKGGKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPN 191
Cdd:PRK10701 121 QATQTKglqetsLTPYkalHFGTLTIDPVNRQVTLAGEEISLSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDR 200

                        170       180       190
                 ....*....|....*....|....*....|.
gi 447173001 192 VVDLYIGYVRKKLKCEKKNRY-IQTIHGRGY 221
Cdd:PRK10701 201 SVDVAISRLRKKLLDNAAEPYrIKTVRNKGY 231
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 4-116 4.66e-11

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 58.06  E-value: 4.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVPIIFISSRDD 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447173001  84 SKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd18159   81 NMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 36-117 6.56e-11

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 57.52  E-value: 6.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  36 EGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQA 114
Cdd:cd17535   35 EALALLRELRPDVVLMDLSMPGMDGIEALRRLRrRYPDLKVIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRA 114


                 ...
gi 447173001 115 ILR 117
Cdd:cd17535  115 VAA 117
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-120 1.23e-10

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 58.43  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQ--VLVIKNERSLAKKIVSGLTQEGHFIL-KLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVII 77
Cdd:COG3707    1 MRGlrVLVVDDEPLRRADLREGLREAGYEVVaEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVIL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 447173001  78 VTDNiSSKDCV-AGLQAGADDYIRKPFAKEELVARVQAILRRSN 120
Cdd:COG3707   81 LTAY-SDPELIeRALEAGVSAYLVKPLDPEDLLPALELALARFR 123
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 4-116 2.48e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 56.19  E-value: 2.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGH-FILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRL---VKMTPVIIVT 79
Cdd:cd19923    3 VLVVDDFSTMRRIIKNLLKELGFnNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRAdgaLSHLPVLMVT 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd19923   83 AEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKIF 119
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 4-112 2.75e-10

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 55.90  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVK-MTPVIIVTDNI 82
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHpSIVVIVLSDNP 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARV 112
Cdd:cd17573   81 KTEQEIEAFKEGADDYIAKPFDFKVLVARI 110
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 21-103 3.45e-10

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 55.21  E-value: 3.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  21 LTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIVTDNISSKDCVAGLQAGADD 97
Cdd:cd19920   18 LRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATrhiPVIFLTALTDTEDKVKGFELGAVD 97


                 ....*.
gi 447173001  98 YIRKPF 103
Cdd:cd19920   98 YITKPF 103
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-119 4.71e-10

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 55.28  E-value: 4.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI 82
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLpTSVIVITAHG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQ-AILRRS 119
Cdd:cd17572   81 SVDIAVEAMRLGAYDFLEKPFDADRLRVTVRnALKHRK 118
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 11-110 5.41e-10

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 55.17  E-value: 5.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  11 RSLAKKIvsgLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR----LVKMTPVIIVTDNISSKD 86
Cdd:cd17546   11 RKVLKKL---LEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRelegGGRRTPIIALTANALEED 87

                         90       100
                 ....*....|....*....|....
gi 447173001  87 CVAGLQAGADDYIRKPFAKEELVA 110
Cdd:cd17546   88 REKCLEAGMDDYLSKPVKLDQLKE 111
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 36-113 7.62e-10

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 54.76  E-value: 7.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  36 EGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARV 112
Cdd:cd17551   36 EALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLedvPIVMITADTDREVRLRALEAGATDFLTKPFDPVELLARV 115


                 .
gi 447173001 113 Q 113
Cdd:cd17551  116 R 116
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 4-118 1.36e-09

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 54.24  E-value: 1.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEgHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLV---KMTPVIIVTD 80
Cdd:cd17539    1 VLLVDDRPSSAERIAAMLSSE-HEVVVEADPDEALFRAAEGPFDLVIVSLALEDFDGLRLCSQLRSLertRQLPILAVAD 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:cd17539   80 PGDRGRLIRALEIGVNDYLVRPIDPNELLARVRTQIRR 117
PRK10610 PRK10610
chemotaxis protein CheY;
5-118 2.14e-09

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 53.82  E-value: 2.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   5 LVIKNERSLAKKIVSGLTQEGHF--ILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR----LVKMtPVIIV 78
Cdd:PRK10610   8 FLVVDDFSTMRRIVRNLLKELGFnnVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRadgaMSAL-PVLMV 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 447173001  79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:PRK10610  87 TAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEK 126
pleD PRK09581
response regulator PleD; Reviewed
 21-117 2.99e-09

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 56.06  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  21 LTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMT---PVIIVT--DNISSKdcVAGLQAGA 95
Cdd:PRK09581  22 LLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDPATthiPVVMVTalDDPEDR--VRGLEAGA 99

                         90       100
                 ....*....|....*....|..
gi 447173001  96 DDYIRKPFAKEELVARVQAILR 117
Cdd:PRK09581 100 DDFLTKPINDVALFARVKSLTR 121
REC_RitR-like cd19922
receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus ...
 4-112 9.01e-09

receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus pneumoniae RitR (Repressor of iron transport Regulator, formerly RR489) is an orphan two-component signal transduction response regulator that is required for lung pathogenicity. It acts to repress iron uptake via binding the pneumococcal iron uptake (Piu) transporter promoter. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. However, members of this family do not contain the phosphorylatable aspartic acid residue and are phosphorylation-independent.


Pssm-ID: 381149 [Multi-domain]  Cd Length: 110  Bit Score: 51.71  E-value: 9.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDniS 83
Cdd:cd19922    1 ILLLEKERNLAHFLSLELQKEGYRVDLVETGQEALSLALETDYDLILLNVNLSDMSAQDFAEKLSRIKPASVIIVLD--H 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447173001  84 SKDcVAG----LQAGADDYIRKPFAKEELVARV 112
Cdd:cd19922   79 WED-LQEeleeVQRFAVSYVVKPVLISNLVDKI 110
pleD PRK09581
response regulator PleD; Reviewed
 3-122 1.23e-08

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 54.52  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIyEQDWDIIILDWDSLSISGPEICRQIRL---VKMTPVIIVT 79
Cdd:PRK09581 157 RILLVDDDVSQAERIANILKEEFRVVVVSDPSEALFNAA-ETNYDLVIVSANFENYDPLRLCSQLRSkerTRYVPILLLV 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 447173001  80 DNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCN 122
Cdd:PRK09581 236 DEDDDPRLVKALELGVNDYLMRPIDKNELLARVRTQIRRKRYQ 278
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 4-102 5.54e-08

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 49.37  E-value: 5.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNIS 83
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLPVIFLTSKDD 80

                         90
                 ....*....|....*....
gi 447173001  84 SKDCVAGLQAGADDYIRKP 102
Cdd:cd19936   81 EIDEVFGLRMGADDYITKP 99
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-125 9.39e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 51.77  E-value: 9.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVTD 80
Cdd:PRK11361   5 NRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRsHETRTPVILMTA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQN 125
Cdd:PRK11361  85 YAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQLQSMKKEI 129
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 49-119 1.08e-07

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 50.48  E-value: 1.08e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447173001  49 IILDWDSLSISGPEICRqiRLVKM---TPVIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRS 119
Cdd:COG4566   47 LLLDVRMPGMSGLELQE--ELAARgspLPVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARD 118
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-145 1.11e-07

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 50.59  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   1 MRQVLVIKNERSLAKKIVSGLTQEGHF--ILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVII 77
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDLevVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLReLDPPPPIIF 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447173001  78 VTdniSSKD-CVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEITFYQFKDLFVDASSNIVK 145
Cdd:COG3279   81 TT---AYDEyALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDRIFVKSGGKLVK 146
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 9-102 1.38e-07

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 48.13  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   9 NERSLAKKIVS-GLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR---LVKMTPVIIVTDNISS 84
Cdd:cd17602    5 DDRPSIQKMIEyFLEKQGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRkssALKDTPIIMLTGKDGL 84

                         90
                 ....*....|....*...
gi 447173001  85 KDCVAGLQAGADDYIRKP 102
Cdd:cd17602   85 VDRIRAKMAGASGYLTKP 102
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 4-102 1.84e-07

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 48.35  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI 82
Cdd:cd17555    3 ILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPdTPVIVVSGAG 82

                         90       100
                 ....*....|....*....|
gi 447173001  83 SSKDCVAGLQAGADDYIRKP 102
Cdd:cd17555   83 VMSDAVEALRLGAWDYLTKP 102
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 4-108 5.17e-07

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 46.85  E-value: 5.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQD--WDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDN 81
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKdeFDLVITDVHMPDMDGFEFLELIRLEMDLPVIMMSAD 80

                         90       100
                 ....*....|....*....|....*..
gi 447173001  82 ISSKDCVAGLQAGADDYIRKPFAKEEL 108
Cdd:cd17584   81 GSTSTVMKGLAHGACDYLLKPVSIEDL 107
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-115 1.12e-06

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 47.22  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVTD 80
Cdd:COG4567    5 RSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALReRDPDARIVVLTG 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQAI 115
Cdd:COG4567   85 YASIATAVEAIKLGADDYLAKPADADDLLAALERA 119
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
120-221 1.14e-06

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 48.69  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001 120 NCNQQneitfYQFKDlFVDASSNIVKKGGKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVWGHNVVVNPNVVDLyIGY 199
Cdd:PRK12370   9 VSNKK-----FVFDD-FILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRC-IYA 81

                         90       100
                 ....*....|....*....|..
gi 447173001 200 VRKKLKCEKKNRYIQTIHGRGY 221
Cdd:PRK12370  82 LRRILSEDKEHRYIETLYGQGY 103
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 4-115 3.38e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 44.52  E-value: 3.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI 82
Cdd:cd17554    3 ILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPdLPVIICTAYS 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447173001  83 SSKDCVAGLqaGADDYIRKPFAKEELVARVQAI 115
Cdd:cd17554   83 EYKSDFSSW--AADAYVVKSSDLTELKETIKRL 113
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 36-114 6.55e-06

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 45.40  E-value: 6.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  36 EGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIV-TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQA 114
Cdd:PRK10651  43 QGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVfSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQ 122
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 2-116 1.13e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 43.06  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLV---KMTPVIIV 78
Cdd:cd17562    1 KKILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLpayKFTPILML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447173001  79 TDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17562   81 TTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-110 1.80e-05

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 42.45  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDwdslsISGP-----EICRQIR---LVKMTPV 75
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSD-----IGMPgmdgyELARRLRelpWLANTPA 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 447173001  76 IIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVA 110
Cdd:cd17580   76 IALTGYGQPEDRERALEAGFDAHLVKPVDPDELIE 110
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 4-102 1.87e-05

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 42.36  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVK---MTPVIIVTD 80
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNAdfdTIPVIFLTA 80

                         90       100
                 ....*....|....*....|..
gi 447173001  81 NISSKDCVAGLQAGADDYIRKP 102
Cdd:cd19927   81 KGMTSDRIKGYNAGCDGYLSKP 102
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 4-102 2.39e-05

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 42.07  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHF--ILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTD 80
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEAGFevVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPdTKIIILSG 81

                         90       100
                 ....*....|....*....|..
gi 447173001  81 NISSKDCVAGLQAGADDYIRKP 102
Cdd:COG4753   82 YSDFEYAQEAIKLGADDYLLKP 103
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 32-122 3.27e-05

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 43.63  E-value: 3.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   32 HNENEGLNIIYEQDWDIIILD-----WDSLSISgpEICRQIRLVKMTPVIIVT----DNISSKdcvaGLQAGADDYIRKP 102
Cdd:TIGR02875  35 HNGVDALELIKEQQPDVVVLDiimphLDGIGVL--EKLNEIELSARPRVIMLSafgqEKITQR----AVALGADYYVLKP 108

                          90       100
                  ....*....|....*....|
gi 447173001  103 FAKEELVARVQAILRRSNCN 122
Cdd:TIGR02875 109 FDLEILAARIRQLAWGTNAD 128
PRK15115 PRK15115
response regulator GlrR; Provisional
 4-119 7.50e-05

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 42.90  E-value: 7.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQI-RLVKMTPVIIVTDNI 82
Cdd:PRK15115   8 LLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIqKVQPGMPVIILTAHG 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRS 119
Cdd:PRK15115  88 SIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALEQS 124
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 4-124 8.89e-05

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 42.94  E-value: 8.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVK-MTPVIIVTDNI 82
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHpMLPVIIMTAHS 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 447173001  83 SSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQ 124
Cdd:PRK10923  86 DLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQQQ 127
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 47-115 1.57e-04

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 40.09  E-value: 1.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447173001  47 DIIILDWDSLSISGPEICRQIR---LVKMTPVIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAI 115
Cdd:cd17557   54 DLILLDLNMPRMDGFEVLREIKadpDLRRIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSL 125
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 126-225 2.05e-04

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 41.57  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001 126 EITFyQFKDLFVDASSNIVKKGGKNLSLTKREYDLLVFLIKNKNTILSREMLLNQVW------GHNVVVNpnvvdlyIGY 199
Cdd:PRK10153   3 QPVF-RIGEWLVTPSENKISRQGREVTLEPRLIDLLVFFAQHSGEVLSRDELIDHVWdraivtDHVVTQS-------ISE 74

                         90       100
                 ....*....|....*....|....*...
gi 447173001 200 VRKKLK--CEKKNRYIQTIHGRGYSMVE 225
Cdd:PRK10153  75 LRKSLKdgREDNPEYIVTVPKRGYKLVA 102
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
3-119 3.42e-04

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 41.17  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR-LVKMTPVIIVTDN 81
Cdd:PRK10365   7 DILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKaLNPAIPVLIMTAY 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 447173001  82 ISSKDCVAGLQAGADDYIRKPFAKEelvaRVQAILRRS 119
Cdd:PRK10365  87 SSVETAVEALKTGALDYLIKPLDFD----NLQATLEKA 120
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 32-112 3.65e-04

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 39.04  E-value: 3.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  32 HNENEGLNIIyEQDWDI--IILDWDSLSISGPEICRQIRLV--KMTPVIIvtdNISSKD----CVAGLQAGADDYIRKPF 103
Cdd:cd17544   31 ANGQEALEVL-EQHPDIklVITDYNMPEMDGFELVREIRKKysRDQLAII---GISASGdnalSARFIKAGANDFLTKPF 106


                 ....*....
gi 447173001 104 AKEELVARV 112
Cdd:cd17544  107 LPEEFYCRV 115
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 4-102 4.14e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 38.51  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIY---------EQDWDIIILDWDSLSISGPEICRQIR---LVK 71
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLEnlakegndlSKELDLIITDIEMPKMDGYELTFELRddpRLA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 447173001  72 MTPVIIVTDNISSKDCVAGLQAGADDYIRKP 102
Cdd:cd19924   81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 21-112 4.51e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 38.68  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  21 LTQEGHFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIR---LVKMTPVIIVTDNISSKDCVAGLQAGADD 97
Cdd:cd17548   19 LESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKedpATRDIPVIALTAYAMKGDREKILEAGCDG 98

                         90
                 ....*....|....*
gi 447173001  98 YIRKPFAKEELVARV 112
Cdd:cd17548   99 YISKPIDTREFLETV 113
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 11-110 8.09e-04

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 37.90  E-value: 8.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  11 RSLAKKIVSGLTQEghfILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKM-TPVIIVTDNI--SSKDC 87
Cdd:cd17593   14 KQLARALPADWDVE---ITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLeTKVIVVSGDVqpEAKER 90

                         90       100
                 ....*....|....*....|...
gi 447173001  88 VAGLqaGADDYIRKPFAKEELVA 110
Cdd:cd17593   91 VLEL--GALAFLKKPFDPEKLAQ 111
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 4-113 8.61e-04

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 37.86  E-value: 8.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHFILKLHNENEGLNIIYEQDWDIIILD-WdsL-SISGPEICRQIR-LVKMTPVIIVTD 80
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDiW--LpDMDGLELLKEIKeKYPDLPVIMISG 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 447173001  81 NISSKDCVAGLQAGADDYIRKPFAKEELVARVQ 113
Cdd:cd17550   79 HGTIETAVKATKLGAYDFIEKPLSLDRLLLTIE 111
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 4-114 8.83e-04

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 37.99  E-value: 8.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   4 VLVIKNERSLAKKIVSGLTQEGHF--ILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDN 81
Cdd:cd19925    3 VLIVEDDPMVAEIHRAYVEQVPGFtvIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTA 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 447173001  82 ISSKDCV-AGLQAGADDYIRKPFAKEELVARVQA 114
Cdd:cd19925   83 ANDVETVrEALRLGVVDYLIKPFTFERLRQRLER 116
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 11-116 1.47e-03

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 37.26  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  11 RSLAKKIvsgLTQEG-HFILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTDNISSKDCVA 89
Cdd:cd17542   13 RMMLKDI---LTKAGyEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSAMGQEEMVK 89

                         90       100
                 ....*....|....*....|....*...
gi 447173001  90 -GLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17542   90 eAIKAGAKDFIVKPFQPERVLEAVEKVL 117
fixJ PRK09390
response regulator FixJ; Provisional
 58-175 2.30e-03

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 37.67  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  58 ISGPEICRQIRLVK-MTPVIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAILRRSNCNQQNEitfyqfkdlf 136
Cdd:PRK09390  60 IDGIELLRRLKARGsPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAKSE---------- 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 447173001 137 vDASSNIVKKGGknlSLTKREYDLLVFLIKNK-NTILSRE 175
Cdd:PRK09390 130 -AVAADIRARIA---SLSERERQVMDGLVAGLsNKVIARD 165
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 36-117 3.47e-03

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 36.36  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  36 EGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTdniSSKDCVAgLQA---GADDYIRKPFAKEEL---V 109
Cdd:cd17532   35 EALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFV---TAYDEYA-VEAfelNAVDYLLKPFSEERLaeaL 110


                 ....*...
gi 447173001 110 ARVQAILR 117
Cdd:cd17532  111 AKLRKRLS 118
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 36-118 3.75e-03

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 36.16  E-value: 3.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  36 EGLNIIYEQDWDIIILDwdslsI-----SGPEICRQIR-LVKMTPVIIVTdnisskdcvaG----------LQAGADDYI 99
Cdd:cd17536   36 EALELIEEHKPDIVITD-----IrmpgmDGLELIEKIReLYPDIKIIILS----------GyddfeyaqkaIRLGVVDYL 100

                         90
                 ....*....|....*....
gi 447173001 100 RKPFAKEELVARVQAILRR 118
Cdd:cd17536  101 LKPVDEEELEEALEKAKEE 119
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 49-116 4.16e-03

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 36.03  E-value: 4.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447173001  49 IILDWDSLSISGPEICRQIRLVKMT-PVIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQAIL 116
Cdd:cd17537   48 LVLDVRMPGMSGLELQDELLARGSNiPIIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-118 4.70e-03

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 35.85  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   2 RQVLVIKNERSLAKKIVSGLTQEGHFIL-KLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTd 80
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVgEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLT- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 447173001  81 NISSKDCV--AGlQAGADDYIRKPFAKEELVARVQAILRR 118
Cdd:cd19932   80 AYSQQDLVerAK-EAGAMAYLVKPFSESDLIPAIEMAIAR 118
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 3-113 6.05e-03

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 35.33  E-value: 6.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001   3 QVLVIKNERS----LAKkivsGLTQEGHFILKLHNENEGLNIIyEQDW-DIIILDWDSLSISGPEICRQIRL-VKMTPVI 76
Cdd:cd19919    2 TVWIVDDDSSirwvLER----ALAGAGLTVTSFENAQEALAAL-ASSQpDVLISDIRMPGMDGLALLAQIKQrHPDLPVI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 447173001  77 IVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQ 113
Cdd:cd19919   77 IMTAHSDLDSAVSAYQGGAFEYLPKPFDIDEAVALVE 113
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
36-114 6.39e-03

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 36.75  E-value: 6.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  36 EGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTP-VIIVTDNISSKDCVAGLQAGADDYIRKPFAKEELVARVQA 114
Cdd:PRK10403  43 SAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAqIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 32-112 8.03e-03

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 34.93  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  32 HNENEGLNIIYEQDWDIIILDWD-SLSISGPEICRQIRLVKMTP----VIIVTDNISSKDCVAGLQAGADDYIRKPFAKE 106
Cdd:cd17589   30 SSGEEALRMCENKTYDIVLCDYNlGKGKNGQQLLEELRHKKLISpstvFIMVTGESSRAMVLSALELEPDDYLLKPFTVS 109


                 ....*.
gi 447173001 107 ELVARV 112
Cdd:cd17589  110 ELRERL 115
PRK14084 PRK14084
DNA-binding response regulator;
21-124 8.59e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 36.27  E-value: 8.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447173001  21 LTQEGHF--ILKLHNENEGLNIIYEQDWDIIILDWDSLSISGPEICRQIRLVKMTPVIIVTdNISSKDCVAGLQAGADDY 98
Cdd:PRK14084  20 LNEIGGFeeINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFA-TAHDQFAVKAFELNATDY 98

                         90       100
                 ....*....|....*....|....*....
gi 447173001  99 IRKPFAK---EELVARVQAILRRSNCNQQ 124
Cdd:PRK14084  99 ILKPFEQkriEQAVNKVRATKAKDDNNAS 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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