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MULTISPECIES: dihydroxy-acid dehydratase [Bacillus]
Protein Classification
dihydroxy-acid dehydratase ( domain architecture ID 10011557 )
dihydroxy-acid dehydratase catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
List of domain hits
Name
Accession
Description
Interval
E-value
PRK00911
PRK00911 dihydroxy-acid dehydratase; Provisional
1-554
0e+00
dihydroxy-acid dehydratase; Provisional
Pssm-ID: 234861
Cd Length: 552
Bit Score: 1034.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 1 MRSDMI K KG FDK APHRS L L K ATGL K DEDFDKPFI A I C NS FI EI I P GHK HLNE FGKL VKE A VRAAG M VPFEFNTIGV D DGI 80
Cdd:PRK00911 1 MRSDMI T KG VER APHRS M L R ATGL T DEDFDKPFI G I A NS WN EI T P CNI HLNE LADA VKE G VRAAG G VPFEFNTIGV S DGI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 81 AMGH I GM R YSL P SRE I IADS V ETVVNAHWFDG MIC IP N CDK IT PGM M MAA L R I N I P TV FV S GGP MAA G K t S KG EVVD L S S 160
Cdd:PRK00911 81 AMGH E GM K YSL V SRE V IADS I ETVVNAHWFDG LVA IP G CDK NM PGM L MAA A R L N V P SI FV Y GGP ILP G R - L KG KDLT L V S 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 161 VFE G VGAY QS GKISEEELK D IE DHG CP SC GSC S GMFTAN S M N CL C E V LG LA LPG N G S I L A I D PR R E EL IKQ A A E KLKI L I 240
Cdd:PRK00911 160 VFE A VGAY AA GKISEEELK E IE RNA CP GA GSC G GMFTAN T M A CL I E A LG MS LPG S G T I P A V D AE R D EL ARE A G E AVVE L L 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 241 E R DIKPRDI V T E EA IDD A F A L DMA M GGSTN T VLH T LA L A Q EAG L D YDMNRIDAV S R R V PHL CKVS P ASNWH MED IDR AGG 320
Cdd:PRK00911 240 E K DIKPRDI L T R EA FEN A I A V DMA L GGSTN A VLH L LA I A H EAG V D LTLDDFNRI S K R T PHL ADLK P SGKYV MED LHE AGG 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 321 I S A IL KE MS r KE G V LH L D RI T A TG Q TL R EN I A E A EIK D KE VI HS L E NP H S EE GGL R ILKGNLA KD GAV I K SGATEVKR F E 400
Cdd:PRK00911 320 I P A VM KE LL - DA G L LH G D CL T V TG K TL A EN L A D A PDP D QD VI RP L D NP I S PT GGL A ILKGNLA PE GAV V K IAGVKPEM F T 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 401 GP CVI F N S QD EA LAG I ML GK V K K GDVVVIRYEGP R GGPGM P EMLAPTSAI A G M GLG AE VAL L TDGRFSG AS RG IS VGH I S 480
Cdd:PRK00911 399 GP ARV F D S EE EA MEA I LA GK I K A GDVVVIRYEGP K GGPGM R EMLAPTSAI V G A GLG DD VAL I TDGRFSG GT RG LC VGH V S 478
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447178558 481 PEAA A GG M IAL L E Q GDI VC ID VEE R L L E V R VSDEEL EK R KKE WK R PEPK V K T G W L GR YA QM V T SA N TGAV LKI P 554
Cdd:PRK00911 479 PEAA V GG P IAL V E D GDI IT ID APN R T L D V L VSDEEL AR R RAA WK P PEPK Y K R G V L AK YA KL V S SA S TGAV TDP P 552
Name
Accession
Description
Interval
E-value
PRK00911
PRK00911 dihydroxy-acid dehydratase; Provisional
1-554
0e+00
dihydroxy-acid dehydratase; Provisional
Pssm-ID: 234861
Cd Length: 552
Bit Score: 1034.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 1 MRSDMI K KG FDK APHRS L L K ATGL K DEDFDKPFI A I C NS FI EI I P GHK HLNE FGKL VKE A VRAAG M VPFEFNTIGV D DGI 80
Cdd:PRK00911 1 MRSDMI T KG VER APHRS M L R ATGL T DEDFDKPFI G I A NS WN EI T P CNI HLNE LADA VKE G VRAAG G VPFEFNTIGV S DGI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 81 AMGH I GM R YSL P SRE I IADS V ETVVNAHWFDG MIC IP N CDK IT PGM M MAA L R I N I P TV FV S GGP MAA G K t S KG EVVD L S S 160
Cdd:PRK00911 81 AMGH E GM K YSL V SRE V IADS I ETVVNAHWFDG LVA IP G CDK NM PGM L MAA A R L N V P SI FV Y GGP ILP G R - L KG KDLT L V S 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 161 VFE G VGAY QS GKISEEELK D IE DHG CP SC GSC S GMFTAN S M N CL C E V LG LA LPG N G S I L A I D PR R E EL IKQ A A E KLKI L I 240
Cdd:PRK00911 160 VFE A VGAY AA GKISEEELK E IE RNA CP GA GSC G GMFTAN T M A CL I E A LG MS LPG S G T I P A V D AE R D EL ARE A G E AVVE L L 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 241 E R DIKPRDI V T E EA IDD A F A L DMA M GGSTN T VLH T LA L A Q EAG L D YDMNRIDAV S R R V PHL CKVS P ASNWH MED IDR AGG 320
Cdd:PRK00911 240 E K DIKPRDI L T R EA FEN A I A V DMA L GGSTN A VLH L LA I A H EAG V D LTLDDFNRI S K R T PHL ADLK P SGKYV MED LHE AGG 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 321 I S A IL KE MS r KE G V LH L D RI T A TG Q TL R EN I A E A EIK D KE VI HS L E NP H S EE GGL R ILKGNLA KD GAV I K SGATEVKR F E 400
Cdd:PRK00911 320 I P A VM KE LL - DA G L LH G D CL T V TG K TL A EN L A D A PDP D QD VI RP L D NP I S PT GGL A ILKGNLA PE GAV V K IAGVKPEM F T 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 401 GP CVI F N S QD EA LAG I ML GK V K K GDVVVIRYEGP R GGPGM P EMLAPTSAI A G M GLG AE VAL L TDGRFSG AS RG IS VGH I S 480
Cdd:PRK00911 399 GP ARV F D S EE EA MEA I LA GK I K A GDVVVIRYEGP K GGPGM R EMLAPTSAI V G A GLG DD VAL I TDGRFSG GT RG LC VGH V S 478
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447178558 481 PEAA A GG M IAL L E Q GDI VC ID VEE R L L E V R VSDEEL EK R KKE WK R PEPK V K T G W L GR YA QM V T SA N TGAV LKI P 554
Cdd:PRK00911 479 PEAA V GG P IAL V E D GDI IT ID APN R T L D V L VSDEEL AR R RAA WK P PEPK Y K R G V L AK YA KL V S SA S TGAV TDP P 552
IlvD
COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
1-554
0e+00
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439899
Cd Length: 558
Bit Score: 1033.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 1 MRSD MIK KG FDK AP H R S LL K ATGL K DEDF D KP F I A I C NS FI EI I PGH K HL NEFGKL VKE AV RAAG M VPFEFNTI G V D DGI 80
Cdd:COG0129 4 MRSD TVT KG RER AP A R A LL R ATGL T DEDF G KP I I G I A NS WN EI V PGH V HL DDLAEA VKE GI RAAG G VPFEFNTI A V S DGI 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 81 AMGH I GMRYSLPSRE I IADS V ET V VNAH W FDG MI CIP N CDKITPGM M MAA L R I NIP TV FV S GGPM AA GK T s K G EVV D LSS 160
Cdd:COG0129 84 AMGH E GMRYSLPSRE L IADS I ET M VNAH C FDG LV CIP G CDKITPGM L MAA A R L NIP SI FV Y GGPM LP GK Y - D G KDL D IVD 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 161 VFE G VGAY QS GKIS E EELK D IE DHG CP S CGSCSGMFTAN S M N CL C E V LGL A LPG N G S I L A IDPR R EE L IKQ A AEKLKI L I 240
Cdd:COG0129 163 VFE A VGAY AA GKIS D EELK E IE RNA CP G CGSCSGMFTAN T M A CL T E A LGL S LPG S G T I P A VSAE R RR L ARE A GRRIVE L V 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 241 E R DIKPRDI V T E EA IDD A F A L DMA M GGSTNTVLH T LA L A Q EAG L D YDMNRI D AV SRR V PHLC KVS P ASNW HMED ID RAGG 320
Cdd:COG0129 243 E K DIKPRDI L T R EA FEN A I A V DMA L GGSTNTVLH L LA I A H EAG V D LTLDDF D RI SRR T PHLC DLK P SGKY HMED LH RAGG 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 321 I S A IL KE MSRK e G V LH L D RI T A TG Q TL R EN I A E A E I - K D KE VI HS L E NP H S EE GGL R IL K GNLA K DGAV I K SGATEVK -- 397
Cdd:COG0129 323 I P A VM KE LLDA - G L LH G D CL T V TG K TL A EN L A D A D I d R D QD VI RP L D NP Y S PT GGL A IL R GNLA P DGAV V K TAGVDES ml 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 398 R FEGP CVI F N S QD EA LAG I ML GK V K K GDVVVIRYEGP R GGPGM P EML A PTSA IA GMGLG AE VAL L TDGRFSG AS RG I S V G 477
Cdd:COG0129 402 V FEGP ARV F D S EE EA VEA I LG GK I K A GDVVVIRYEGP K GGPGM R EML S PTSA LK GMGLG KS VAL I TDGRFSG GT RG L S I G 481
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447178558 478 H I SPEAA A GG M IAL L E Q GDI VC ID VEE R L L EVR VSDEEL EK R KKE WK R PEP K V KT G W L GR YA QM V T SA NT GAV LKI P 554
Cdd:COG0129 482 H V SPEAA E GG P IAL V E D GDI IT ID IPA R T L DLL VSDEEL AR R RAA WK P PEP R V TS G V L AK YA KL V S SA SK GAV TDP P 558
ILVD_EDD
pfam00920 Dehydratase family;
31-549
0e+00
Dehydratase family;
Pssm-ID: 459998
Cd Length: 513
Bit Score: 888.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 31 KP F I A I C NS FIEII P G H K HL N E FGKL VKE A VR A AG M VP F EFNTIGV D DGIAMGH I GMRYSLPSRE I IADS V E TVVN AH W F 110
Cdd:pfam00920 1 KP I I G I A NS YSDLV P C H V HL R E LAEA VKE G VR E AG G VP A EFNTIGV C DGIAMGH E GMRYSLPSRE L IADS I E EMLR AH P F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 111 DG MIC I PN CDKI T PGM M MAA L R I NIP TV FVSGGPM AA G KTSKG E vvdlssv FE G VGAY QS GKISEEEL KD IE DHG CP S CG 190
Cdd:pfam00920 81 DG LVL I GG CDKI V PGM L MAA A R L NIP AI FVSGGPM LP G GSGTD E ------- FE A VGAY AA GKISEEEL LE IE RAA CP G CG 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 191 SC S GM F TAN S M N CL C E V LGL A LPG NGS I L A IDPR R EE L IKQ A AEKLKI L I E R DIKPRDI V T EE A IDD A FAL DMA M GGSTN 270
Cdd:pfam00920 154 SC G GM G TAN T M A CL A E A LGL S LPG SAT I P A VSAE R LR L ARE A GRRIVE L V E E DIKPRDI L T RK A FEN A IVV DMA L GGSTN 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 271 T VLH T LA L A Q EAG L D YDMNRI D AV SR R VP H L CKVS P ASNWH MED ID RAGG IS A I LKE M sr KEGV LH L D RI T A TG Q TL R EN 350
Cdd:pfam00920 234 A VLH L LA I A R EAG V D LTLDDF D RI SR K VP L L ADLK P SGKYL MED FH RAGG VP A V LKE L -- LDAL LH G D VL T V TG K TL G EN 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 351 I A E AE IK D KE VI HS L E NP H S EE GGL RI LKGNLA K DGAV I K SG A T -- E VKR FEGP CVI F N S QDE ALA G I ML GK V K K GDVVV 428
Cdd:pfam00920 312 L A D AE VR D QD VI RP L D NP I S PT GGL AV LKGNLA P DGAV V K TS A V dp E MLV FEGP ARV F D S EED ALA A I LD GK I K A GDVVV 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 429 IRYEGP R GGPGMPEML A PTSA IA G M GLG AE VAL L TDGRFSGASRG I S V GH I SPEAA A GG M IAL LEQ GDI VC ID VEE R L L E 508
Cdd:pfam00920 392 IRYEGP K GGPGMPEML T PTSA LL G A GLG KD VAL I TDGRFSGASRG P S I GH V SPEAA V GG P IAL VRD GDI IR ID IPN R T L D 471
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 447178558 509 VR VSDEEL EK R KKE WK R PEPKVK - T G W L GR YA QM V T SA NT GA 549
Cdd:pfam00920 472 LL VSDEEL AA R RAA WK P PEPKVK g R G Y L AK YA KL V S SA SE GA 513
ilvD
TIGR00110 dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth ...
21-552
0e+00
dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth step in valine and isoleucine biosynthesis. It contains a catalytically essential [4Fe-4S] cluster This model generates scores of up to 150 bits vs. 6-phosphogluconate dehydratase, a homologous enzyme. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272910
Cd Length: 535
Bit Score: 845.16
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 21 ATG LK DEDF D KPFI AIC NS FIE I I PGH K HL NEFGKL VKE AVR AAG M V P FEFNTI G V D DGIAMGH I GM R YSLPSREIIADS 100
Cdd:TIGR00110 1 ATG FT DEDF G KPFI GVA NS YTT I V PGH M HL RDLAQA VKE GIE AAG G V A FEFNTI A V C DGIAMGH E GM K YSLPSREIIADS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 101 VET V VNAH W FDG MI CIP N CDKITPGM M MAA L R I NIP TV FV S GGPM AA G K T SK G EVV DL S S V FE G VG A Y QS GKISEEEL KD 180
Cdd:TIGR00110 81 VET M VNAH R FDG LV CIP S CDKITPGM L MAA A R L NIP SI FV T GGPM LP G H T KL G KKI DL V S A FE A VG E Y AA GKISEEEL EE 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 181 IE DHG CP S CGSCSGMFTAN S M N CL C E V LGL A LPG NGSI LA IDPRREELI K QAAEKLKI L IERD IKPRDI V T E EA IDD A FA 260
Cdd:TIGR00110 161 IE RSA CP G CGSCSGMFTAN T M A CL T E A LGL S LPG CSTM LA TSAEKKRIA K NSGKRIVE L VKKN IKPRDI L T K EA FEN A IT 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 261 L DMA M GGSTNTVLH T LA L A Q EAG L D YDMNRI D AV SR R VPH LCKVS P ASNWH MED ID RAGGI S A I LKE MS R k EG V LH L D RI 340
Cdd:TIGR00110 241 V DMA L GGSTNTVLH L LA I A N EAG V D LSLDDF D RL SR K VPH IASLA P SGKYV MED LH RAGGI P A V LKE LD R - EG L LH G D TL 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 341 T A TG Q TL R E NIAE A EIK -- DKE VI HS L E NP HSE EGGL R ILKGNLA KD GAV I K SGATE -- VKR FEGP CVI F N S QD EAL AG I 416
Cdd:TIGR00110 320 T V TG K TL G E ILEQ A PVI pe GQD VI RP L D NP VHQ EGGL A ILKGNLA PN GAV V K IAGVD ed MTK FEGP AKV F E S EE EAL EA I 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 417 ML GK V K K GDVVVIRYEGP R GGPGMPEMLAPTSAI A GMGLG AE VAL L TDGRFSG AS RG ISV GH I SPEAA A GG M IAL L E Q GD 496
Cdd:TIGR00110 400 LG GK I K E GDVVVIRYEGP K GGPGMPEMLAPTSAI K GMGLG KS VAL I TDGRFSG GT RG LCI GH V SPEAA E GG P IAL V E D GD 479
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 447178558 497 I VC ID VEE R L L EVR VSDEEL EK R KKE WK R PEP KVKT G W L GR YA QM V T SA NT GAVL K 552
Cdd:TIGR00110 480 I II ID IPN R K L DLQ VSDEEL AE R RAS WK A PEP RYVK G Y L AK YA KL V S SA DE GAVL D 535
Name
Accession
Description
Interval
E-value
PRK00911
PRK00911 dihydroxy-acid dehydratase; Provisional
1-554
0e+00
dihydroxy-acid dehydratase; Provisional
Pssm-ID: 234861
Cd Length: 552
Bit Score: 1034.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 1 MRSDMI K KG FDK APHRS L L K ATGL K DEDFDKPFI A I C NS FI EI I P GHK HLNE FGKL VKE A VRAAG M VPFEFNTIGV D DGI 80
Cdd:PRK00911 1 MRSDMI T KG VER APHRS M L R ATGL T DEDFDKPFI G I A NS WN EI T P CNI HLNE LADA VKE G VRAAG G VPFEFNTIGV S DGI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 81 AMGH I GM R YSL P SRE I IADS V ETVVNAHWFDG MIC IP N CDK IT PGM M MAA L R I N I P TV FV S GGP MAA G K t S KG EVVD L S S 160
Cdd:PRK00911 81 AMGH E GM K YSL V SRE V IADS I ETVVNAHWFDG LVA IP G CDK NM PGM L MAA A R L N V P SI FV Y GGP ILP G R - L KG KDLT L V S 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 161 VFE G VGAY QS GKISEEELK D IE DHG CP SC GSC S GMFTAN S M N CL C E V LG LA LPG N G S I L A I D PR R E EL IKQ A A E KLKI L I 240
Cdd:PRK00911 160 VFE A VGAY AA GKISEEELK E IE RNA CP GA GSC G GMFTAN T M A CL I E A LG MS LPG S G T I P A V D AE R D EL ARE A G E AVVE L L 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 241 E R DIKPRDI V T E EA IDD A F A L DMA M GGSTN T VLH T LA L A Q EAG L D YDMNRIDAV S R R V PHL CKVS P ASNWH MED IDR AGG 320
Cdd:PRK00911 240 E K DIKPRDI L T R EA FEN A I A V DMA L GGSTN A VLH L LA I A H EAG V D LTLDDFNRI S K R T PHL ADLK P SGKYV MED LHE AGG 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 321 I S A IL KE MS r KE G V LH L D RI T A TG Q TL R EN I A E A EIK D KE VI HS L E NP H S EE GGL R ILKGNLA KD GAV I K SGATEVKR F E 400
Cdd:PRK00911 320 I P A VM KE LL - DA G L LH G D CL T V TG K TL A EN L A D A PDP D QD VI RP L D NP I S PT GGL A ILKGNLA PE GAV V K IAGVKPEM F T 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 401 GP CVI F N S QD EA LAG I ML GK V K K GDVVVIRYEGP R GGPGM P EMLAPTSAI A G M GLG AE VAL L TDGRFSG AS RG IS VGH I S 480
Cdd:PRK00911 399 GP ARV F D S EE EA MEA I LA GK I K A GDVVVIRYEGP K GGPGM R EMLAPTSAI V G A GLG DD VAL I TDGRFSG GT RG LC VGH V S 478
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447178558 481 PEAA A GG M IAL L E Q GDI VC ID VEE R L L E V R VSDEEL EK R KKE WK R PEPK V K T G W L GR YA QM V T SA N TGAV LKI P 554
Cdd:PRK00911 479 PEAA V GG P IAL V E D GDI IT ID APN R T L D V L VSDEEL AR R RAA WK P PEPK Y K R G V L AK YA KL V S SA S TGAV TDP P 552
IlvD
COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
1-554
0e+00
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439899
Cd Length: 558
Bit Score: 1033.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 1 MRSD MIK KG FDK AP H R S LL K ATGL K DEDF D KP F I A I C NS FI EI I PGH K HL NEFGKL VKE AV RAAG M VPFEFNTI G V D DGI 80
Cdd:COG0129 4 MRSD TVT KG RER AP A R A LL R ATGL T DEDF G KP I I G I A NS WN EI V PGH V HL DDLAEA VKE GI RAAG G VPFEFNTI A V S DGI 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 81 AMGH I GMRYSLPSRE I IADS V ET V VNAH W FDG MI CIP N CDKITPGM M MAA L R I NIP TV FV S GGPM AA GK T s K G EVV D LSS 160
Cdd:COG0129 84 AMGH E GMRYSLPSRE L IADS I ET M VNAH C FDG LV CIP G CDKITPGM L MAA A R L NIP SI FV Y GGPM LP GK Y - D G KDL D IVD 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 161 VFE G VGAY QS GKIS E EELK D IE DHG CP S CGSCSGMFTAN S M N CL C E V LGL A LPG N G S I L A IDPR R EE L IKQ A AEKLKI L I 240
Cdd:COG0129 163 VFE A VGAY AA GKIS D EELK E IE RNA CP G CGSCSGMFTAN T M A CL T E A LGL S LPG S G T I P A VSAE R RR L ARE A GRRIVE L V 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 241 E R DIKPRDI V T E EA IDD A F A L DMA M GGSTNTVLH T LA L A Q EAG L D YDMNRI D AV SRR V PHLC KVS P ASNW HMED ID RAGG 320
Cdd:COG0129 243 E K DIKPRDI L T R EA FEN A I A V DMA L GGSTNTVLH L LA I A H EAG V D LTLDDF D RI SRR T PHLC DLK P SGKY HMED LH RAGG 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 321 I S A IL KE MSRK e G V LH L D RI T A TG Q TL R EN I A E A E I - K D KE VI HS L E NP H S EE GGL R IL K GNLA K DGAV I K SGATEVK -- 397
Cdd:COG0129 323 I P A VM KE LLDA - G L LH G D CL T V TG K TL A EN L A D A D I d R D QD VI RP L D NP Y S PT GGL A IL R GNLA P DGAV V K TAGVDES ml 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 398 R FEGP CVI F N S QD EA LAG I ML GK V K K GDVVVIRYEGP R GGPGM P EML A PTSA IA GMGLG AE VAL L TDGRFSG AS RG I S V G 477
Cdd:COG0129 402 V FEGP ARV F D S EE EA VEA I LG GK I K A GDVVVIRYEGP K GGPGM R EML S PTSA LK GMGLG KS VAL I TDGRFSG GT RG L S I G 481
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447178558 478 H I SPEAA A GG M IAL L E Q GDI VC ID VEE R L L EVR VSDEEL EK R KKE WK R PEP K V KT G W L GR YA QM V T SA NT GAV LKI P 554
Cdd:COG0129 482 H V SPEAA E GG P IAL V E D GDI IT ID IPA R T L DLL VSDEEL AR R RAA WK P PEP R V TS G V L AK YA KL V S SA SK GAV TDP P 558
ILVD_EDD
pfam00920 Dehydratase family;
31-549
0e+00
Dehydratase family;
Pssm-ID: 459998
Cd Length: 513
Bit Score: 888.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 31 KP F I A I C NS FIEII P G H K HL N E FGKL VKE A VR A AG M VP F EFNTIGV D DGIAMGH I GMRYSLPSRE I IADS V E TVVN AH W F 110
Cdd:pfam00920 1 KP I I G I A NS YSDLV P C H V HL R E LAEA VKE G VR E AG G VP A EFNTIGV C DGIAMGH E GMRYSLPSRE L IADS I E EMLR AH P F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 111 DG MIC I PN CDKI T PGM M MAA L R I NIP TV FVSGGPM AA G KTSKG E vvdlssv FE G VGAY QS GKISEEEL KD IE DHG CP S CG 190
Cdd:pfam00920 81 DG LVL I GG CDKI V PGM L MAA A R L NIP AI FVSGGPM LP G GSGTD E ------- FE A VGAY AA GKISEEEL LE IE RAA CP G CG 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 191 SC S GM F TAN S M N CL C E V LGL A LPG NGS I L A IDPR R EE L IKQ A AEKLKI L I E R DIKPRDI V T EE A IDD A FAL DMA M GGSTN 270
Cdd:pfam00920 154 SC G GM G TAN T M A CL A E A LGL S LPG SAT I P A VSAE R LR L ARE A GRRIVE L V E E DIKPRDI L T RK A FEN A IVV DMA L GGSTN 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 271 T VLH T LA L A Q EAG L D YDMNRI D AV SR R VP H L CKVS P ASNWH MED ID RAGG IS A I LKE M sr KEGV LH L D RI T A TG Q TL R EN 350
Cdd:pfam00920 234 A VLH L LA I A R EAG V D LTLDDF D RI SR K VP L L ADLK P SGKYL MED FH RAGG VP A V LKE L -- LDAL LH G D VL T V TG K TL G EN 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 351 I A E AE IK D KE VI HS L E NP H S EE GGL RI LKGNLA K DGAV I K SG A T -- E VKR FEGP CVI F N S QDE ALA G I ML GK V K K GDVVV 428
Cdd:pfam00920 312 L A D AE VR D QD VI RP L D NP I S PT GGL AV LKGNLA P DGAV V K TS A V dp E MLV FEGP ARV F D S EED ALA A I LD GK I K A GDVVV 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 429 IRYEGP R GGPGMPEML A PTSA IA G M GLG AE VAL L TDGRFSGASRG I S V GH I SPEAA A GG M IAL LEQ GDI VC ID VEE R L L E 508
Cdd:pfam00920 392 IRYEGP K GGPGMPEML T PTSA LL G A GLG KD VAL I TDGRFSGASRG P S I GH V SPEAA V GG P IAL VRD GDI IR ID IPN R T L D 471
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 447178558 509 VR VSDEEL EK R KKE WK R PEPKVK - T G W L GR YA QM V T SA NT GA 549
Cdd:pfam00920 472 LL VSDEEL AA R RAA WK P PEPKVK g R G Y L AK YA KL V S SA SE GA 513
ilvD
TIGR00110 dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth ...
21-552
0e+00
dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth step in valine and isoleucine biosynthesis. It contains a catalytically essential [4Fe-4S] cluster This model generates scores of up to 150 bits vs. 6-phosphogluconate dehydratase, a homologous enzyme. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272910
Cd Length: 535
Bit Score: 845.16
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 21 ATG LK DEDF D KPFI AIC NS FIE I I PGH K HL NEFGKL VKE AVR AAG M V P FEFNTI G V D DGIAMGH I GM R YSLPSREIIADS 100
Cdd:TIGR00110 1 ATG FT DEDF G KPFI GVA NS YTT I V PGH M HL RDLAQA VKE GIE AAG G V A FEFNTI A V C DGIAMGH E GM K YSLPSREIIADS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 101 VET V VNAH W FDG MI CIP N CDKITPGM M MAA L R I NIP TV FV S GGPM AA G K T SK G EVV DL S S V FE G VG A Y QS GKISEEEL KD 180
Cdd:TIGR00110 81 VET M VNAH R FDG LV CIP S CDKITPGM L MAA A R L NIP SI FV T GGPM LP G H T KL G KKI DL V S A FE A VG E Y AA GKISEEEL EE 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 181 IE DHG CP S CGSCSGMFTAN S M N CL C E V LGL A LPG NGSI LA IDPRREELI K QAAEKLKI L IERD IKPRDI V T E EA IDD A FA 260
Cdd:TIGR00110 161 IE RSA CP G CGSCSGMFTAN T M A CL T E A LGL S LPG CSTM LA TSAEKKRIA K NSGKRIVE L VKKN IKPRDI L T K EA FEN A IT 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 261 L DMA M GGSTNTVLH T LA L A Q EAG L D YDMNRI D AV SR R VPH LCKVS P ASNWH MED ID RAGGI S A I LKE MS R k EG V LH L D RI 340
Cdd:TIGR00110 241 V DMA L GGSTNTVLH L LA I A N EAG V D LSLDDF D RL SR K VPH IASLA P SGKYV MED LH RAGGI P A V LKE LD R - EG L LH G D TL 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 341 T A TG Q TL R E NIAE A EIK -- DKE VI HS L E NP HSE EGGL R ILKGNLA KD GAV I K SGATE -- VKR FEGP CVI F N S QD EAL AG I 416
Cdd:TIGR00110 320 T V TG K TL G E ILEQ A PVI pe GQD VI RP L D NP VHQ EGGL A ILKGNLA PN GAV V K IAGVD ed MTK FEGP AKV F E S EE EAL EA I 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 417 ML GK V K K GDVVVIRYEGP R GGPGMPEMLAPTSAI A GMGLG AE VAL L TDGRFSG AS RG ISV GH I SPEAA A GG M IAL L E Q GD 496
Cdd:TIGR00110 400 LG GK I K E GDVVVIRYEGP K GGPGMPEMLAPTSAI K GMGLG KS VAL I TDGRFSG GT RG LCI GH V SPEAA E GG P IAL V E D GD 479
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 447178558 497 I VC ID VEE R L L EVR VSDEEL EK R KKE WK R PEP KVKT G W L GR YA QM V T SA NT GAVL K 552
Cdd:TIGR00110 480 I II ID IPN R K L DLQ VSDEEL AE R RAS WK A PEP RYVK G Y L AK YA KL V S SA DE GAVL D 535
PRK12448
PRK12448 dihydroxy-acid dehydratase; Provisional
1-550
0e+00
dihydroxy-acid dehydratase; Provisional
Pssm-ID: 237104
Cd Length: 615
Bit Score: 750.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 1 M RS DMIKK G FDK A PH R S L LK ATG L KDEDF D KP F IA IC NSF IEII PGH K HL NEF G K LV KEAVR AAG M V PF EFNTI G VDDGI 80
Cdd:PRK12448 3 Y RS RTTTH G RNM A GA R A L WR ATG M KDEDF G KP I IA VV NSF TQFV PGH V HL KDL G Q LV AREIE AAG G V AK EFNTI A VDDGI 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 81 AMGH I GM R YSLPSRE I IADSVE TV VNAH WF D G M I CI P NCDKITPGM M MAALR I NIP T VFVSGGPM A AGKT - SKGEVVD L S 159
Cdd:PRK12448 83 AMGH G GM L YSLPSRE L IADSVE YM VNAH CA D A M V CI S NCDKITPGM L MAALR L NIP V VFVSGGPM E AGKT k LSDKIIK L D 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 160 S V FEG V G A YQS g KI S E E ELKD IE DHG CP S CGSCSGMFTANSMNCL C E V LGL A LPGNGS I LA IDPR R EE L IKQ A AEKLKI L 239
Cdd:PRK12448 163 L V DAM V A A ADP - SV S D E DVAQ IE RSA CP T CGSCSGMFTANSMNCL T E A LGL S LPGNGS L LA THAD R KQ L FLE A GRRIVE L 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 240 IE R ------- DIK PR D I V T EE A IDD A FA LD M AMGGSTNTVLH T LA L AQEA GL D YD M NR ID AV SR R VP H LCKV S P A - SNW H 311
Cdd:PRK12448 242 AK R yyeqdde SVL PR S I A T KA A FEN A MT LD I AMGGSTNTVLH L LA A AQEA EV D FT M AD ID RL SR K VP C LCKV A P N t QKY H 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 312 MED ID RAGGI SA IL K E MS R K e G V LH L D RI T AT G Q TL R E NIAEAE I --- K D KE V --------------------------- 361
Cdd:PRK12448 322 MED VH RAGGI MG IL G E LD R A - G L LH T D VP T VH G L TL G E ALDQWD I mrt Q D EA V keffraapggirttvafsqdcrwdsld 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 362 ------- I H S L E NPH S EE GGL RI L K GN L A K DG AVI K S - G AT E - VKR F E GP CVI F N SQD E A LAG I ML GKVK K GDVVVIRYE 432
Cdd:PRK12448 401 tdrengc I R S V E HAY S KD GGL AV L Y GN I A E DG CIV K T a G VD E s ILK F T GP ARV F E SQD D A VEA I LG GKVK A GDVVVIRYE 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 433 GP R GGPGM P EML A PTS AIAGM GLG AEV AL L TDGRFSG ASR G I S V GH I SPEAA A GG M I A L L E Q GDI VC ID VEE R LLEVR VS 512
Cdd:PRK12448 481 GP K GGPGM Q EML Y PTS YLKSK GLG KAC AL I TDGRFSG GTS G L S I GH V SPEAA S GG A I G L V E D GDI IE ID IPN R SINLL VS 560
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 447178558 513 DEEL EK R KKE -------- WK - RPEPKVKTGW L GR YA QMV TSA NT GAV 550
Cdd:PRK12448 561 DEEL AA R RAA qeargdka WK p KNRERKVSFA L KA YA ALA TSA DK GAV 607
PRK06131
PRK06131 dihydroxy-acid dehydratase; Validated
15-551
3.20e-151
dihydroxy-acid dehydratase; Validated
Pssm-ID: 235708
Cd Length: 571
Bit Score: 445.78
E-value: 3.20e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 15 HRS LL K AT G LK DE D FD - K P F I A ICN SFIEII P GHK H LNEFGKL VK EA V RA AG MV P F EF NT I gvddgi AM G HIGM R ysl P S 93
Cdd:PRK06131 21 HRS FM K NQ G YP DE L FD g R P I I G ICN TWSDLN P CNA H FRQLAER VK RG V LE AG GF P V EF PV I ------ SL G ESFL R --- P T 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 94 ---- R EII A DS VE TVVNAHWF DG MICIPN CDK I TP GMM M A A LRINI P TVFV SGGPM AA GK t S KGE VVDL - SS V FEGVGAY 168
Cdd:PRK06131 92 amly R NLA A MD VE EMIRGYPI DG VVLLGG CDK T TP ALL M G A ASVDL P AIVL SGGPM LN GK - H KGE RLGS g TD V WKYWEEL 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 169 QS G K I SE EE LKDI E DHGCP S C G S C SG M F TA NS M N C LC E V LG LA LPGN GS I L A I D P RR EELIKQAAEKLKILIER D I KP R D 248
Cdd:PRK06131 171 RA G E I DL EE FLEA E AGMAR S A G T C NT M G TA ST M A C MA E A LG MS LPGN AA I P A V D A RR IRMAELTGRRIVEMVHE D L KP S D 250
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 249 I V T E EA IDD A FALDM A M GGSTN T V L H TL A L A QE AG LDY D MNRI D AVS R R VP H L CKVS P ASNWH MED IDR AGG IS A I L K E M 328
Cdd:PRK06131 251 I L T R EA FEN A IRVNA A I GGSTN A V I H LI A I A GR AG VEL D LDDW D RIG R D VP V L VNLQ P SGEYL MED FYY AGG LP A V L R E L 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 329 SR keg V LHLD RI T AT G Q TL R EN I A E A EIKDKE VI HS L E NP HSE EGG LRI L K GNLA K DGAVIK - S G A T - E VKRF EG PC V I F 406
Cdd:PRK06131 331 GE --- L LHLD AL T VN G K TL G EN L A G A PVYNDD VI RP L D NP LKP EGG IAV L R GNLA P DGAVIK p S A A S p E LLKH EG RA V V F 407
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 407 NS -------- Q D EA L A gimlgk V KKGD V V V I R YE GP R G G PGMPE -- MLAPTSAIAGM G LGAE V AL l T D G R F SG ASR G IS V 476
Cdd:PRK06131 408 EG yedykari D D PD L D ------ V DEDT V L V L R NA GP K G Y PGMPE vg NMPIPKKLLRQ G VKDM V RI - S D A R M SG TAY G TV V 480
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447178558 477 G H IS PEAAAGG MI AL LEQ GD IVCI DV EE R L L EVR VSDEEL EK R KKE W KR P E P KVKT G WLGR Y AQM V TS A NT G AVL 551
Cdd:PRK06131 481 L H VA PEAAAGG PL AL VRT GD RIRL DV PA R R L DLL VSDEEL AR R RAA W PP P P P RAER G YQEL Y RDH V LQ A DE G CDF 555
PRK13017
PRK13017 dihydroxy-acid dehydratase; Provisional
13-552
2.44e-126
dihydroxy-acid dehydratase; Provisional
Pssm-ID: 237272
Cd Length: 596
Bit Score: 382.77
E-value: 2.44e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 13 A PHRSLLKAT GL KD E DFD -- KP F I A I CNSFIEII P GHK H LN E FGKL VKE AV R A AG MV P F EF NTI gvddgi AMGHI G M R ys 90
Cdd:PRK13017 27 A LYLERYMNY GL TR E ELQ sg KP I I G I AQTGSDLS P CNR H HL E LAER VKE GI R D AG GI P M EF PVH ------ PIQET G K R -- 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 91 l P S ---- R EIIADSVETVVNAHWF DG MICIPN CDK I TP GMM MAA LRINI P TVFV SGGPM AA G K t SK GE V V DLSS V - FEGV 165
Cdd:PRK13017 99 - P T aald R NLAYLGLVEILYGYPL DG VVLTTG CDK T TP ACL MAA ATVDL P AIVL SGGPM LD G W - HE GE R V GSGT V i WKAR 176
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 166 GAYQS G K I SE EE LKDIEDHGC PS C G S C SG M F TA NS MN C L C E V LG LA LPG NGS I L A IDPR R EELIKQAAEKLKILIER D I K 245
Cdd:PRK13017 177 ELLAA G E I DY EE FMELVASSA PS V G H C NT M G TA ST MN A L A E A LG MS LPG CAA I P A PYRE R GQMAYATGKRIVEMVWE D L K 256
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 246 P R DI V T E EA IDD A FALDM A M GGSTN TVL H TL A L A QE AG LDYDMNRIDA V SRR VP H L CKVS PA SNWHM ED ID RAGG IS A I L 325
Cdd:PRK13017 257 P S DI L T R EA FEN A IVVNS A I GGSTN API H LI A I A RH AG VELSLDDWQR V GED VP L L VNLQ PA GKYLG ED FH RAGG VP A V L 336
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 326 K E MS R K e G V LH L D RI T AT G Q T LR ENIA E A EIK D KE VI HSLEN P HS E EG G LRI L K GNL A k D G A VI K ------------- S G 392
Cdd:PRK13017 337 A E LL R A - G L LH G D AL T VS G R T IG ENIA G A PAP D RD VI RPYDA P LK E RA G FLV L R GNL F - D S A IM K tsviseefreryl S E 414
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 393 ATEVKR FEG PC V I F NSQDEAL A G I --- M L G k VKKGDVV VIR YE GP R G G PG MP E -- MLA P TS A IAGM G LGAEVAL l T DGR F 467
Cdd:PRK13017 415 PGDENA FEG RA V V F DGPEDYH A R I ddp A L D - IDEHCIL VIR GA GP V G Y PG SA E vv NMQ P PA A LLKR G IRSLPCI - G DGR Q 492
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 468 SG A S RGI S VGHI SPEAA A GG MI ALL EQ GD IVC ID VEE R LLE V R VSDEEL EK R KKEW K R P E P KVK T G W LGR Y AQM V TSAN T 547
Cdd:PRK13017 493 SG T S GSP S ILNA SPEAA V GG GL ALL RT GD RIR ID LNK R RVD V L VSDEEL AR R RAAL K P P V P PSQ T P W QEL Y RKH V GQLS T 572
....*
gi 447178558 548 GA V L K 552
Cdd:PRK13017 573 GA C L E 577
PRK13016
PRK13016 dihydroxy-acid dehydratase; Provisional
15-549
2.57e-126
dihydroxy-acid dehydratase; Provisional
Pssm-ID: 237271
Cd Length: 577
Bit Score: 382.15
E-value: 2.57e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 15 HRS LLKAT G LKD EDFD - KP F IAI C N SFIEII P G H K H LN E FGKL VK EA V RA AG MV P F E FNTIGVDDGI a MGHIG M R Y slps 93
Cdd:PRK13016 25 HRS RMMQM G YAP EDFD g KP V IAI L N TWSDAN P C H G H FR E RVED VK RG V LQ AG GF P L E LPALSLSENF - VKPTT M L Y ---- 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 94 R EII A DSV E TVVNA H WF DG MICIPN CDK I TPG MM M A A LRINI P TVFVSG GPM AA G KT s K G E V VDLS S - VFEGVGAYQS G K 172
Cdd:PRK13016 100 R NLL A MET E ELIRS H PV DG AVLMGG CDK T TPG LV M G A ISMGL P MIYLPA GPM LR G NY - R G K V LGSG S d AWKYWDERRA G N 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 173 I SEE E LKD IE DHGCP S C G S C SG M F TA NS M NCLC E V LGL A LPG NG SI L A I D PRREELIKQAAEKLKILIER D IK P RD I V T E 252
Cdd:PRK13016 179 I TQA E WLE IE GGIAR S Y G T C MT M G TA ST M TAIA E A LGL T LPG AS SI P A A D ANHQRMAALCGRRIVEMVWE D LT P SQ I L T K 258
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 253 E A IDD A FALD MA M G G STN T V L H TL A L A QE AG LDYDMNRI D AVS R R VP HLCKVS P A - SNWH MED IDR AGG IS A I lke M SRK 331
Cdd:PRK13016 259 A A FEN A ITVA MA T G C STN A V I H LI A M A RR AG VPLSLDDL D RCG R T VP VIANIR P S g KTYL MED FFY AGG LR A L --- M KQL 335
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 332 EGV LHLD RI T A TG Q TL RE N IAE A EIKDKE VI HS L E NP HSE EG G L RI L K GNLA K DGAVIK SG A TEV K -- RFE GP CVI F N S Q 409
Cdd:PRK13016 336 GDK LHLD AL T V TG K TL GD N LEG A KVYNDD VI RP L D NP VYA EG S L AV L R GNLA P DGAVIK PA A CDP K fl VHR GP ALV F D S Y 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 410 D E AL A G I MLGK -- V KKGD V V V I R YE GP R GGPGMPE -- ML APTSAIAGM G L g AEVALLT D G R F SG A S R G IS V G H IS PEA AA 485
Cdd:PRK13016 416 P E MK A A I DDEN ld V TPDH V M V L R NA GP Q GGPGMPE wg ML PIPKKLLKQ G V - RDMVRIS D A R M SG T S Y G AC V L H VA PEA YV 494
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447178558 486 GG MI AL LEQ GDI VCI DV EE R L L EVR VSDEEL EK R KKE W KR PE PKVKT G WLGRYA Q M V TS A NT G A 549
Cdd:PRK13016 495 GG PL AL VRT GDI IEL DV PA R R L HLL VSDEEL AR R RAA W QP PE RRYER G YGWMFS Q H V EQ A DK G C 558
yjhG_yagF
TIGR03432 putative dehydratase, YjhG/YagF family; This homolog of dihydroxy-acid dehydratases has an odd, ...
52-511
5.74e-65
putative dehydratase, YjhG/YagF family; This homolog of dihydroxy-acid dehydratases has an odd, sparse distribution. Members are found in two Acidobacteria, two Planctomycetes, Bacillus clausii KSM-K16, and (in two copies each) in strains K12-MG1655 and W3110 of Escherichia coli. The local context is not well conserved, but a few members are adjacent to homologs of the gluconate:H+ symporter (see TIGR00791). [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 163260
Cd Length: 640
Bit Score: 223.52
E-value: 5.74e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 52 E F G K L V K E A --- VRAA G M VPF EFNTIGVD DG IAM G HI GM RY SLP S R EII A DSVETVVNAH - WFD G M I C I PN CDK IT P G MM 127
Cdd:TIGR03432 85 E V G L L M K A A aee IKRD G A VPF AGFVSDPC DG RTQ G TT GM FD SLP Y R NDA A MVMRRLIRSL p TRK G V I G I AT CDK GL P A MM 164
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 128 MA - A LRINI PTV F V S GG PMAAGKTSK -- G E V vdlssvf EGV GA - YQS G K I SE EE LKDI edh GC PS C G S ---- C SGMF TA N 199
Cdd:TIGR03432 165 MA l A ATHHL PTV L V P GG VTLPPEVGE da G K V ------- QTI GA r FSN G E I TL EE AAEA --- GC RA C A S pggg C QFLG TA A 234
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 200 SMNCLC E V LGLALP GNGSILAID P RREELIKQA A EKLKI L IERDIKP RDI V T EE AI DD A FALDM A M GGSTN TV LH TL A L A 279
Cdd:TIGR03432 235 TSQVVA E A LGLALP HSALAPSGQ P IWLDMARRS A RAALE L SQKGLST RDI L T DK AI EN A MVVHA A F GGSTN LL LH IP A I A 314
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 280 QE AG LDY ---- D MN RI D avs R R VP H L CKVS P AS -- NWHMEDIDR AGG ISAILKEM s R KE G V LH L D RI T A TG Q TL R EN I -- 351
Cdd:TIGR03432 315 HA AG CRR ptvd D WT RI N --- R K VP R L VDAL P NG pv GHPTVRVFL AGG VPEVMLHL - R RA G L LH E D VL T V TG E TL G EN L dw 390
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 352 --------------- AEAEIKDKE VI H S LENPH s EE G GLRIL --- KGNLA KD G A VIKS -------- GATE V K R FE GP CVI 405
Cdd:TIGR03432 391 wenserrarmkqrlr ERDGVDPDD VI M S PAQAK - AR G LTSTV tfp KGNLA PE G S VIKS taidpsvv DEDG V Y R HT GP ARV 469
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447178558 406 F N S QDE A L A G I ML GK VKK GDV V V IRYE GP R G G p GM P E MLAP TSA IAGMGL G AE VAL L TD G RFSG A S R G ISV GH IS PEA A A 485
Cdd:TIGR03432 470 F S S EKS A I A A I KH GK IEA GDV L V LIGR GP S G T - GM E E TYQV TSA LKYLSF G KH VAL I TD A RFSG V S T G ACI GH VG PEA L A 548
490 500
....*....|....*....|....*.
gi 447178558 486 GG M I ALLEQ GD IVC I DVEERL LE VR V 511
Cdd:TIGR03432 549 GG P I GKVRD GD LIE I IIDRNT LE GT V 574
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
