|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
23-495 |
0e+00 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 900.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 23 KTKKAITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAI 102
Cdd:PRK10642 13 KLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 103 TVIIMSISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAA 182
Cdd:PRK10642 93 TIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 183 TVALITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHSEQQAQKSK-----PQKFSFKEIFVKHKRSL 257
Cdd:PRK10642 173 VVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDReglqdGPKVSFKEIATKHWRSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 258 LVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYP 337
Cdd:PRK10642 253 LTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLAIP 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 338 AFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPA 417
Cdd:PRK10642 333 AFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESTQNLMMPA 412
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447183265 418 YYLMICGVVGIATAMYLKETANKPLIGGVPIAHNIEEAQELLEEFHETIEQKIENIDQKIQELQQKRQKLADKHPDIA 495
Cdd:PRK10642 413 YYLMVVAVIGLITGVTMKETANRPLKGATPAASDIQEAKEILVEHYDNIEQKIDDIDQEIAELQAKRTRLVQQHPRID 490
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
28-438 |
0e+00 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 538.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 28 ITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIM 107
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 108 SISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALI 187
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 188 THAVGEARFAEWGWRIPFFLALPLGIIGLYLRnrleetpvyqqhseqqaqkskpqkfsfkeifvkhkRSLLVCIGLVIST 267
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR-----------------------------------RPLLICIGLVLVF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 268 NVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGVN 347
Cdd:cd17366 206 NVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSI 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 348 YQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTAT-LVETTHNLMVPAYYLMICGVV 426
Cdd:cd17366 286 AAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASwLVSATGNPLMPAYYLMVAAVV 365
|
410
....*....|..
gi 447183265 427 GIATAMYLKETA 438
Cdd:cd17366 366 GLVAVLFLTETA 377
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
34-427 |
1.02e-152 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 440.56 E-value: 1.02e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 34 GNAIEWFDFGVYGYVAYVLGKVFFPDA-SPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTF 112
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSgDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 113 GIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAVG 192
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 193 EARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYqqhsEQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYY 272
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVF----EKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 273 MLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFV-LLNSGVNYQIF 351
Cdd:TIGR00883 237 LITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMaLLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447183265 352 IGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVI-AGLTPTLTATLVETTHNLMVPAYYLMICGVVG 427
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIfGGFAPYIAAALVAMTGDWYAIGYYLAALALIG 393
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
25-432 |
6.38e-137 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 400.75 E-value: 6.38e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 25 KKAITAAALGNAIEWFDFGVYGYVA-YVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAIT 103
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAaLVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 104 VIIMSISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAAT 183
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 184 VALITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHSEQQAQKSKPqkfsFKEIFVKHKRSLLVCIGL 263
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAP----LVEVLRRHWRALLLAIGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 264 VISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLN 343
Cdd:cd17369 237 RLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 344 SGVNYQIFIGLLILALSL-NMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTAT-LVETTHNLMVPAYYLM 421
Cdd:cd17369 317 TGSTWLIVLAAVVVLGVLhGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATaLVAATGSWWPVALYLA 396
|
410
....*....|.
gi 447183265 422 ICGVVGIATAM 432
Cdd:cd17369 397 ALAVISLVAAL 407
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
28-435 |
3.07e-100 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 306.91 E-value: 3.07e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 28 ITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIM 107
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 108 SISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALI 187
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 188 THAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPvyqqHSEQQAQKSKPQKFSFKEiFVKHKRSLLVCIGLVIST 267
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETE----SFEAIAESNEASAGTLRE-LRRHPRELLLVVGLTAGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 268 NVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRP-FIFIGSFSLIFlSYPAFVLLNSGV 346
Cdd:cd17367 236 TLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPlLLFFGIGGTLA-TVPLLSALDHTD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 347 NYQIFIGLLILALSL---NMSIgvMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVEttHNLMVPAYYLMIC 423
Cdd:cd17367 315 SPYTAFALVLVGLVFlsgYTSI--NAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLK--SIGHEWVFFWYVA 390
|
410
....*....|..
gi 447183265 424 GVVGIATAMYLK 435
Cdd:cd17367 391 GLIAISLVVYLR 402
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
28-438 |
4.48e-92 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 286.19 E-value: 4.48e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 28 ITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIM 107
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 108 SISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALI 187
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 188 THAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHseqqaqKSKPQKFSFKEIFVKHKRSLLVCIGLVIST 267
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLER------KARPTRRELFALLANNRRIILLGMLLVAGS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 268 NVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGVN 347
Cdd:cd17368 235 TVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 348 YQIFIG-LLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVI-AGLTPTLTATLVETTHNLMVPAYYLMICGV 425
Cdd:cd17368 315 FGRLLLvLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIfGGFAQFIVTWLIELTGSPLAPAWYLMGAAL 394
|
410
....*....|...
gi 447183265 426 VGIATAMYLKETA 438
Cdd:cd17368 395 LGLLATLMLRETA 407
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-432 |
1.24e-85 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 267.55 E-value: 1.24e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 28 ITAAALGNAIEWFDFGVYGYVAYVLGKVFfpdaSPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIM 107
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 108 SISTFGIGLIPSyetiglwaPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGaatvALI 187
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA----ALV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 188 THAVGEARFAEWGWRIPFFLALPLGIIGLYLRnrleetpvyqqhseqqaqkskpqkfsfkeifvkhkRSLLVCIGLVIST 267
Cdd:cd17316 145 ASLLIPLLSGDWGWRILFLIGALPALLALLLR-----------------------------------RRTLLLILLWFFI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 268 NVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGVn 347
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSP- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 348 YQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVG 427
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
|
....*
gi 447183265 428 IATAM 432
Cdd:cd17316 349 LIVAL 353
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
23-437 |
2.79e-84 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 266.98 E-value: 2.79e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 23 KTKKAITAAALGNAIEWFDFGVYGYVA-YVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLA 101
Cdd:PRK09952 19 RARRAALGSFAGAVVDWYDFLLYGITAaLVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLM 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 102 ITVIIMSISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGA 181
Cdd:PRK09952 99 LTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLST 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 182 ATVALITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHSEQQAQKSKpqKFSFKEIFVKHKRSLLVCI 261
Cdd:PRK09952 179 GLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKK--RIPVIEALLRHPGAFLKII 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 262 GLVISTNVTYYMLLTYLPSYFSHNLGYSEAhgALIIIAVMVGML--FVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAF 339
Cdd:PRK09952 257 ALRLCELLTMYIVTAFALNYSTQNLGLPRE--LFLNIGLLVGGLscLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFF 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 340 VLLNSGVNYQIFIGLLILA-LSLNMSIGVMASTLPALFPTEIRYSALGIAFNF-SVVIAGLTPTLTATLVETTH-NLMVP 416
Cdd:PRK09952 335 MALEAQSIFWIVFFSIMLAnIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVaSVVGGGFTPFIAAALVTYFGgSWHSV 414
|
410 420
....*....|....*....|.
gi 447183265 417 AYYLMICGVVGIATAMYLKET 437
Cdd:PRK09952 415 AIYLLAGCLISAMTALLMKDN 435
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
26-442 |
1.32e-71 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 233.68 E-value: 1.32e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 26 KAITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVI 105
Cdd:PRK15075 15 RAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 106 IMSISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVA 185
Cdd:PRK15075 95 IMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 186 LITHAVGEARFAEWGWRIPFF---LALPLgiiGLYLRNRLEETPvyqqhsEQQAQKSKPqkfSFKEIF---VKHKRSLLV 259
Cdd:PRK15075 175 LLNQWLSPAQMAEWGWRIPFLigcLIVPF---IFLIRRSLEETE------EFLARKHRP---SMREIFrslAANWRIVLA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 260 CIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAF 339
Cdd:PRK15075 243 GMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYPAL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 340 VLLNSGVNY-QIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVI-AGLTPTLTATLVETTHNLMVPA 417
Cdd:PRK15075 323 SWLVAAPSFaRMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIfGGFTPAISTWLIHVTGDKAAPG 402
|
410 420
....*....|....*....|....*
gi 447183265 418 YYLMICGVVGIATAMYLKETANKPL 442
Cdd:PRK15075 403 YWLSFAAVCGLIATLVLYRRRGARL 427
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
27-396 |
9.75e-67 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 221.22 E-value: 9.75e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 27 AITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVII 106
Cdd:PRK10406 23 AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 107 MSISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVAL 186
Cdd:PRK10406 103 MCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 187 ITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETpvyqqhsEQQAQKSKPQKFSFKEIFvKHKRSLLVCIGLVIS 266
Cdd:PRK10406 183 LQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET-------SQQETRALKEAGSLKGLW-RNRRAFIMVLGFTAA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 267 TNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRR-PFIFIGSFSLIFlSYPAFVLLNSG 345
Cdd:PRK10406 255 GSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRtSMLCFGSLAALF-TVPILSALQNV 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447183265 346 VNYQIFIGLLILALSLNMSIGVMASTLPA-LFPTEIRysALGIAFNFSVVIA 396
Cdd:PRK10406 334 SSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVR--ALGVGLSYAVANA 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
31-443 |
4.03e-60 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 204.04 E-value: 4.03e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 31 AALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAAL-----ATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVI 105
Cdd:pfam00083 5 AALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALsvlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 106 IMSISTFGIGLIPSYetiglWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVA 185
Cdd:pfam00083 85 LFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 186 LITHAVgearfAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQH---------SEQQAQKSKPQKFSFKEIFVKHKRS 256
Cdd:pfam00083 160 GLNKTS-----NSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEkgrleeareVLAKLRGVPDVDRELDEIKDSLEAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 257 --------------------LLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEahgALIIIAVMVGMLFVQPVIG-YLS 315
Cdd:pfam00083 235 qeaekaswkelfstktrrqrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD---SFLVTIIVGVVNFVFTFIAiFLV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 316 DKFGRRPFIFIGSFS----LIFLSYPAFVLLN--SGVNYQIFIGLLILALSLNMSIG-VMASTLPALFPTEIRYSALGIA 388
Cdd:pfam00083 312 DRFGRRPLLLLGAAGmaicFVILGIVALLGVSksDWAGIVAIVFIALFIAFFAMGWGpVPWVIVSELFPLSVRSKAMALA 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 447183265 389 FNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYLKETANKPLI 443
Cdd:pfam00083 392 TAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLE 446
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-437 |
3.33e-44 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 160.16 E-value: 3.33e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 30 AAALGNAIEWFDFGVYGYVAYVLGKVFFPDAspsvqmIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSI 109
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDE------AEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 110 STFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDfgsiAGFVLGAATVALITH 189
Cdd:cd17371 77 FTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ----SGWAVGWLLATLLAA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 190 AVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHseQQAQKSKPQKFSFKEIFVKH-KRSLLVCIGLVISTN 268
Cdd:cd17371 145 LLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAA--RAARRHFADRPSLRELFSPPlLRTTLLASLLATGAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 269 VTYYMLLTYLPSYFSHNLGYSEaHGALIIIAVMV-GMLFVQPVIGYLSDKFGRRPfIFIGSFSLIFLSYPAFVLLNSGvN 347
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSF-EGSAGYLVVTIlGGFLGYLAGGFLADRIGRRN-NFALFALGSAISILLYFFLPLS-P 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 348 YQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLveTTHNLMVPAYYLM--ICGV 425
Cdd:cd17371 300 TLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFL--ATSGSLGTAIAVFaaVYYI 377
|
410
....*....|..
gi 447183265 426 VGIATAMYLKET 437
Cdd:cd17371 378 AGLVLALLLPET 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-441 |
8.81e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 158.89 E-value: 8.81e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 27 AITAAALGNAIEWFDFGVYGYVAYVLGKVFfpDASPSVQMIAalatFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVII 106
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF--GLSAAQLGLL----FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 107 MSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAATVAL 186
Cdd:COG2223 80 LGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLA----AGGGNLGAAVAAF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 187 ITHAVgearFAEWGWRIPFFL-ALPLGIIGLYLRNRLEETPvyqqhsEQQAQKSKPQKFSFKEIFvKHKRSLLVCIGLVI 265
Cdd:COG2223 148 LAPLL----IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPP------AGAAAAAKASLRDQLEAL-RDPRFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 266 STnVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPfIFIGSFSLIFLSYPAFVLLNSG 345
Cdd:COG2223 217 TF-GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 346 VnYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGV 425
Cdd:COG2223 295 L-WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLAL 373
|
410
....*....|....*.
gi 447183265 426 VGIATAMYLKETANKP 441
Cdd:COG2223 374 VALVLTLLLYRRPRRA 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-398 |
5.00e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 155.90 E-value: 5.00e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 24 TKKAITAAALGNAIEWFDFGVYGYVAYVLGKVFfpDASPSvqmiAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAIT 103
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADL--GASPA----QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 104 VIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAAT 183
Cdd:COG2814 82 LLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 184 VALITHAvgearfaeWGWRIPFFLALPLGIIGLYLRNR-LEETPvyqqhseqqAQKSKPQKFSFKEIFvkHKRSLLVCIG 262
Cdd:COG2814 154 GGLLADL--------FGWRWVFLVNAVLALLALLLLLRlLPESR---------PAARARLRGSLRELL--RRPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 263 LVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGsFSLIFLSYPAFVLL 342
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG-LLLLALGLLLLALA 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447183265 343 NSGVnyQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGL 398
Cdd:COG2814 294 GSLW--LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-438 |
3.48e-41 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 151.18 E-value: 3.48e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 26 KAITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASpsvqmiAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVI 105
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAA------QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 106 IMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVA 185
Cdd:COG2271 84 LWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 186 LITHAvgearfaeWGWRIPFFLALPLGIIGLYLRnrleetpvyqqhseqqaqkskpqkfsfkeifvkhkrsLLVCIGLVI 265
Cdd:COG2271 156 WLLAA--------FGWRAAFLILGLPGLLLALLR-------------------------------------FWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 266 STNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRP-FIFIGSFSLIFLSYPAFVLLNS 344
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPS 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 345 GvnYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICG 424
Cdd:COG2271 271 P--ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALAL 348
|
410
....*....|....
gi 447183265 425 VVGIATAMYLKETA 438
Cdd:COG2271 349 LAALLALLLLRETR 362
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
23-329 |
6.89e-36 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 134.94 E-value: 6.89e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 23 KTKKAITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDaSPSVQMIAALAtfsvpFIFRPLGGLFFGHLGDKYGRQKVLAI 102
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGAS-SAQLGWIVSAY-----LLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 103 TVIIMSISTFGIGLIPSyetiglwaPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAA 182
Cdd:COG0477 85 GLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 183 TVALITHAvgearfaeWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHSEQQAQKSKPQKFSFKEIFVKHKRSLLVCIG 262
Cdd:COG0477 157 LGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447183265 263 LVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSF 329
Cdd:COG0477 229 LLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
73-387 |
3.87e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.37 E-value: 3.87e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIF 152
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 153 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAAtvalithaVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPvyqqHS 232
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPL--------LGGLLADALGYRAPFLVCAALALLALVLALLLLPEP----RP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 233 EQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIG 312
Cdd:cd17325 177 PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAG 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447183265 313 YLSDKFGRRPFIFIGSFsLIFLSYPAFVLLNSGvnYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGI 387
Cdd:cd17325 257 KLSDRIGRKPLILIGLL-LSAVALLLLPLATSF--WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-407 |
4.61e-28 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 115.53 E-value: 4.61e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 25 KKAITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASpSVQMIAALATFSVPFifrplGGLFFGHLGDKYGRQKVLAITV 104
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPV-QLGFLFSAGLIGMAF-----GALFFGPLADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 105 IIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAATV 184
Cdd:TIGR00895 90 LLFSVFTLLCALATNV--------TQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM----FCGYPIGAAVG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 185 ALITHAVGearfAEWGWRIPFFLA--------------LPLGIIGLYLR---------NRLEETPVYQQHSEQQAQKSKP 241
Cdd:TIGR00895 158 GFLAGWLI----PVFGWRSLFYVGgiaplllllllmrfLPESIDFLVSKrpetvrrivNAIAPQMQAEAQSALPEQKSTQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 242 Q--KFSFKEIFV-KHKRSLLVCIGLVISTNVTYYMLLTYLPsYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKF 318
Cdd:TIGR00895 234 GtkRSVFKALFQgKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 319 GRRPFIFIGSFSLIFLSYPAFVLLNSGVnyqIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGL 398
Cdd:TIGR00895 313 GPRVTALLLLLGAVFAVLVGSTLFSPTL---LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAII 389
|
....*....
gi 447183265 399 TPTLTATLV 407
Cdd:TIGR00895 390 GPILAGYLL 398
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
73-400 |
1.17e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 113.28 E-value: 1.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIF 152
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 153 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAvgearfaeWGWRIPFFLALPLGIIGLYLRNRLEETPVyqqhS 232
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--------FGWRAAFLILAILSLLAAVLLLLPRPPPE----S 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 233 EQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHnLGYSEAHGALIIIAVMVGMLFVQPVIG 312
Cdd:pfam07690 178 KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 313 YLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFS 392
Cdd:pfam07690 257 RLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
|
....*...
gi 447183265 393 VVIAGLTP 400
Cdd:pfam07690 337 SLGGALGP 344
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
26-432 |
2.47e-25 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 108.63 E-value: 2.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 26 KAITAAALGNAIEWFDFGVYGYVAYVLGKVFfpdaspSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVI 105
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLITLVLTEVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 106 IMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAATVA 185
Cdd:PRK03893 94 LFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL----ISGFSIGAVVAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 186 LITHAVGEArfaeWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQhsEQQAQKSKPQKFSFkeIFVKHKRSL-------- 257
Cdd:PRK03893 162 QVYSLVVPV----WGWRALFFIGILPIIFALWLRKNLPEAEDWKE--KHAGKAPVRTMVDI--LYRGEHRIInilltlaa 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 258 ----------------------LVCIGLVISTNV--------TYYMLL--------------TYLPSYFSHNLGYSEAHG 293
Cdd:PRK03893 234 aaalwfcfagnlqnaaivavlgLLCAAIFISFMVqssgkrwpTGVMLMvvvlfaflyswpiqALLPTYLKTDLGYDPHTV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 294 ALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLlnsGVNYQIFIGLLILALSLnMSIGVmASTLP 373
Cdd:PRK03893 314 ANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAI---GGANVWVLGLLLFFQQM-LGQGI-SGLLP 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447183265 374 AL----FPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETT---HNLMVPAYYLMICGVVGIATAM 432
Cdd:PRK03893 389 KLiggyFDTEQRAAGLGFTYNVGALGGALAPILGALIAQRLdlgTALASLSFSLTFVVILLIGLDM 454
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
73-428 |
8.40e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 97.11 E-value: 8.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGAAIF 152
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 153 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALIthavgeARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPvyqQHS 232
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGIL------ASSLGFGWRAVFLIAAALALLAAILLLLVVPDP---PES 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 233 EQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVI-STNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVI 311
Cdd:cd06174 180 ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIfLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 312 GYLSDKFGRRPFIFIgsFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNF 391
Cdd:cd06174 260 GLLSDRLIGRKPLLL--IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTF 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 447183265 392 SVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGI 428
Cdd:cd06174 338 GFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
25-422 |
2.84e-21 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 96.15 E-value: 2.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 25 KKAITAAALGNAIEWFDFGVYGYVAYVLgkvffpDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITV 104
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLI------KADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 105 IIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAATV 184
Cdd:PRK12307 91 VAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL----VSGFGIGNIIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 185 ALITHAVGEArfaeWGWRIPFFLALPLGIIGLYLRNRLEET-----PVYQQHSEQQAQKSKPQKFSFKEIFVKHKRSLLV 259
Cdd:PRK12307 159 AYFMPSFAEA----YGWRAAFFVGLLPVLLVIYIRARAPESkeweeAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 260 CIGLVI-STNVTYYMLLTYLPSYFSHNlGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPA 338
Cdd:PRK12307 235 CVFIVLfSIFGANWPIFGLLPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 339 FVLlnSGVNYQIFIGLLILALSLNMSI-GVMASTLPALFPTEIRYSALGIAFNFSVViAGLTPTLTATLVETTHNLMVPA 417
Cdd:PRK12307 314 FRI--PQDNYLLLGACLFGLMATNVGVgGLVPKFLYDYFPLEVRGLGTGLIYNLAAT-SGTFNSMAATWLGITMGLGAAL 390
|
....*
gi 447183265 418 YYLMI 422
Cdd:PRK12307 391 TFIVA 395
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
82-406 |
1.94e-20 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 93.02 E-value: 1.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFGSIAGFVLGAATVALITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYqqhseqqaqkskp 241
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 242 qkfsfkeIFVKHKRSLLVCIGL-----VISTNVTYYmlltYLPSYFShNLGYSEAHGALI--------IIAVMVGMLFVq 308
Cdd:cd17359 190 -------LVSKGKPILIIGIGLaifqqFVGINVIFY----YGPEIFQ-NAGFSENAALLQtigigvvnVIFTIIAILLV- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 309 pvigylsDKFGRRPFIFIGSF----SLIFLSYPAFVLLNSGVN-YQIFIGLLILALSLNMSIG-VMASTLPALFPTEIRY 382
Cdd:cd17359 257 -------DKVGRKPLLLIGSIgmaiSLLLIGTAFYFAPGSQASgIVALVLILLFVAFFAMSWGpVTWVLLSEIFPNRIRG 329
|
330 340 350
....*....|....*....|....*....|
gi 447183265 383 SALGIA------FNFsvVIAGLTPTLTATL 406
Cdd:cd17359 330 LAMGIAvfflwiANF--LVSLTFPILLAAF 357
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
85-434 |
3.56e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 91.85 E-value: 3.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 85 LFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglwaPILLLIVKIVQGFSiggeysGAAIF------VAEYSP 158
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIG------AAAIMpaslalIAATFP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 159 DRKRGFMGSWLDFGSIAGFVLGAATVALITHAvgearfaeWGWRIPFFLALPLGIIGLYLrnrleetpvyqqhseqqaqk 238
Cdd:cd17321 115 GERRGRALGLWGAVVGIGAALGPLLGGLLLEL--------FGWRWIFLINVPIGLVALLL-------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 239 skpqkfsfkeifvkHKRSLLVCIGLVIsTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKF 318
Cdd:cd17321 167 --------------ARTFSGAVLAAFL-LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 319 GRRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTE-----------IRY--SAL 385
Cdd:cd17321 232 GPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEkagaasgilntARQlgGAL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 447183265 386 GIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYL 434
Cdd:cd17321 312 GVALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALAL 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
73-434 |
1.35e-19 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 89.94 E-value: 1.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglwaPILLLIVKIVQGFSIGGEYSGAAIF 152
Cdd:cd17319 44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS--------LTSLYVLRFLLGVAEAGFFPGAIKA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 153 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAvgearfaeWGWRIPFFLalpLGIIGLYLrnrleeTPVYqqhs 232
Cdd:cd17319 116 LAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL--------FGWRWAFII---EGLLGLLL------AVLW---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 233 eqqaqkskpqkfsfkeiFVKHKRSLLVCIGlVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIG 312
Cdd:cd17319 175 -----------------WFYLRQVWGLALG-YFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 313 YLSDKF---GRRPFIFIGSFSLIFLSYPAFVLLNSGVnyqIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAF 389
Cdd:cd17319 237 RLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVV---AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLIN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447183265 390 NFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYL 434
Cdd:cd17319 314 SGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
82-372 |
1.68e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.92 E-value: 1.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGfmgswldfgSIAGFVLGAATVALITHAVGEARFAE-WGWRIPFFLALPLGIIGLYLRNRLEETpvyqqhseQQAQKSK 240
Cdd:cd17324 121 RG---------RAIGLVFSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLLPS--------LPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 241 PQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGR 320
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 447183265 321 RPFIFIGSFSLIFLsypAFVLLNSGVNYQIFIGLLILALsLNMSIGVMASTL 372
Cdd:cd17324 264 RALLIALLLLAAAL---LLLTLLGPSPLLLLVGLVLWGL-GFFAAHSALQTR 311
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
63-431 |
1.06e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 87.61 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 63 SVQMIAALATFS--VPFIFRPLgglfFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGF 140
Cdd:cd17478 29 SYAQAGLLVSVFsiTSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY--------WLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 141 SIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIaGFVLGAATVALIthavgearFAEWGWRIPFFLALPLGIIGLYLRN 220
Cdd:cd17478 97 GSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNL-GFALGPLIAAAL--------VALFGGLGLLILLIIPGLAVALLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 221 RLeetpvyqQHSEQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNlGYSEAHGALIIIAV 300
Cdd:cd17478 168 RL-------RPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 301 MVGMLFVQPVIGYLSDKFGRRpFIFIGSFSLIFLSYPAFVLLNSGVNYqifIGLLILALSLNMSIGVMASTLPALFPTEI 380
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRR-RVIIASLLLAAPFLLLFLLTPGIWSY---ILLVLAGFLLFASFPVTVVLAQELLPGNV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 447183265 381 RYsALGIAFNFSVVIAGLTPTLTATLVETTHnlmvPAYYLMICGVVGIATA 431
Cdd:cd17478 316 GL-ASGLMMGLSFGLGGIGAPVLGALADAFG----LESVLLILALLPLLGA 361
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
52-434 |
1.16e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 87.63 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 52 LGKVFFPDASPSVQMIaalatFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLL 131
Cdd:cd17473 25 IAQHFVPNSELLVPLL-----LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--------AL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 132 LIVKIVQGFSIGGEYSGAAIFVAEYSPDRKR----GFMGSWLDFGSIAGFVLGAAtvalithavgearFAEWGWRIPFFL 207
Cdd:cd17473 92 LASRALLGIGVAGIMTLATALIGDYFEGEERakmlGLQSAAMSLGGVVFLLLGGA-------------LAEIGWRAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 208 -ALPLGIIGLYLRNRLEETPVYQQHSEQQAQKSKPqkfsfkeifvKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNL 286
Cdd:cd17473 159 yLLALPVLILVLLFLPEPARKSKSAASPGAATAAA----------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 287 GYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGsFSLIFLSYpaFVLLNSGVNYQIFIGLLILALSLNMSIG 366
Cdd:cd17473 229 GGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG-FALMALGF--LLLALASGLWVVLLGAILAGLGFGLLLP 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447183265 367 VMASTLPALFPTEIRYSALGI---AFNFSvviAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYL 434
Cdd:cd17473 306 TLNSWAMSLVPPELRGRAMGIvtsAFFLG---QFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
68-434 |
2.12e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.85 E-value: 2.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 68 AALATfSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYS 147
Cdd:COG2807 55 AGLLT-TLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIGAGIAVGNV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 148 GAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHavgearfaeWGWRIPF-FLALPLGIIGLYLrnrleetp 226
Cdd:COG2807 126 LLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA---------LGWRGALaVWALLALLALLLW-------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 227 VYQQHSEQQAQKSKPQKFSFKEIFvKHKRSLLVCIGLVIsTNVTYYMLLTYLPSYFsHNLGYSEAHGALIIIAVMVGMLF 306
Cdd:COG2807 189 LPLLRRRPAAAAAAPAAASLRSLW-RSPLAWLLTLFFGL-QSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 307 VQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGVnyqIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSAL- 385
Cdd:COG2807 266 GSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSL---PWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALs 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 447183265 386 GIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYL 434
Cdd:COG2807 343 GMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-373 |
3.80e-18 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 86.49 E-value: 3.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 23 KTKKAITAAALGNAIewFDFGVYGYVAYVLGKVFFpdASPSVqmiAALATFSVPF---IFRPLGGLFFGHLGDKYGRQK- 98
Cdd:COG2211 10 KEKLAYGLGDLGLNL--AFGLLSAYLLYFYTDVLG--LSAAL---VGLILLVARLwdaITDPLIGALSDRTRTRWGRRRp 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 99 VLAITVIIMSISTFGIGLIPSYETIG--LWAPILLLIvkivqgFSIGgeYSGAAI----FVAEYSPDRK-RGFMGSWLDF 171
Cdd:COG2211 83 WILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLL------LGLA--YTLVNIpysaLGAELTPDYEeRTRLSSWRFA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 172 GSIAGFVLGAATVALITHAVGEArfAEWGWRIPFFLALPLGIIGLYL-RNRLEETPVyqqhseqqaqkSKPQKFSFKEIF 250
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGD--AALGYRLTALIFAVLGLLAFLLtFFGTKERPV-----------PEEEKVSLKESL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 251 --VKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPfIFIGS 328
Cdd:COG2211 222 kaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKK-AFIIG 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447183265 329 FSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLP 373
Cdd:COG2211 301 LLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
40-388 |
5.60e-18 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 85.79 E-value: 5.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 40 FDFGVYGYVAYVLGKVFF----PDASPSVQMIAALATFSVPFifrplGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIG 115
Cdd:cd17364 13 YDLFSISLVTKILGRLYYggkgSLPSGVSGLVNAAALVGTII-----GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 116 LIPSYETIGLWApiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFM----GSWLDFGSIAGfvlgaATVALITHAV 191
Cdd:cd17364 88 LSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavFAMQGFGILAG-----AIVTLILSAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 192 GEARF-------AEWGWRIPFFLALPLGIIGLYLRnrleetpvyqqhseqqaqkskpqkfsfkeifvkhkRSLLVCIGLV 264
Cdd:cd17364 161 FEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFR-----------------------------------KHLLGTAGTW 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 265 ISTNVTYYMLLTYLPSYFS----------HNLGYSEAHGALIIIAvmVGMLFVQPVIGYLSDKFGRRPFIFIGSFSL-IF 333
Cdd:cd17364 206 FLLDIAFYGQNLFQSTIISaigfsktmnaYQELFNIAVGQLIIAL--AGTVPGYWFTVFLIDRIGRKKIQMMGFFGMtIF 283
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447183265 334 LSYPAFVLLNSGVNYQIFIGLLILALSL-NMSIGVMASTLPA-LFPTEIRYSALGIA 388
Cdd:cd17364 284 LLILAGPYDHWKISTIGFFVLYGLTFFFsNFGPNTTTFIVPAeVFPARVRSTCHGIS 340
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-434 |
9.66e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 84.57 E-value: 9.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 63 SVQMIAALatfsvpfIFRPLGGLffghLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglwaPILLLIVKIVQGFSI 142
Cdd:cd17489 38 GLFTLAAL-------LARPFAGR----LLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 143 GGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAvgearfaeWGWRIPFFLALPLGIIGLYLRNRL 222
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH--------LGFAVLFIVAAVLALLALLLVFLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 223 EETPVyqqhseQQAQKSKPQKFSFKEIFVkhKRSLLVCIGLVISTnVTYYMLLTYLPSYFSHnLGYSEAhgALIIIAVMV 302
Cdd:cd17489 171 KDPPP------VAAEEAEAGTRAFRRLVE--KKVLPPALILFLAS-IAYGAISTFLPLYAAE-RGISNA--GLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 303 GMLFVQPVIGYLSDKFGRRPFIFIGsfsLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRY 382
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKTVIIPG---LLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447183265 383 SALGIAFNFSVVIAGLTPTLTATLVETTHnlmVPAYYLMICGVVGIATAMYL 434
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFG---YRAMFLLAAVVVLLALVLYI 364
|
|
| Osmo_CC |
pfam08946 |
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal ... |
451-494 |
1.08e-17 |
|
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function.
Pssm-ID: 430338 Cd Length: 45 Bit Score: 76.65 E-value: 1.08e-17
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 447183265 451 NIEEAQELLEEFHETIEQKIENIDQKIQELQQKRQKLADKHPDI 494
Cdd:pfam08946 2 DRQEAKELLQEHYDNIEQKIEDIDEEIAALEEKRQRLVDQHPHI 45
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
66-387 |
3.46e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 83.00 E-value: 3.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 66 MIAALAT-FSVPFIFRplgGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGG 144
Cdd:cd17474 35 QVGLLITaFTLPAAVL---MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL--------LLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 145 EYSGAAIFVAEYSPDRKR----GFMGSWLDFGSIAGFVLGAAtvalithavgearFAEWGWRIPFFLALPLGIIGLYLRN 220
Cdd:cd17474 104 LGPLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLGGL-------------LAAISWRYPFFLLAALIPVAFLAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 221 RLEEtpvyqqhSEQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAV 300
Cdd:cd17474 171 FLLP-------EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGW 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 301 MVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSypaFVLLNSGVNYQIFIGLLILA-LSLNMSIGVMASTLPALFPTE 379
Cdd:cd17474 244 SVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS---LLLLGFVPSLALLLIAIVLFgLGLGLNLPLLTTLVTELAPEE 320
|
....*...
gi 447183265 380 IRYSALGI 387
Cdd:cd17474 321 ERGTASSL 328
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
35-407 |
2.77e-16 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 79.94 E-value: 2.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 35 NAIEWFDFGVYGYVAyvlgkvffPDASPSVQMIAALAT--FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTF 112
Cdd:cd17365 8 IVLDGFDLAVMGFVA--------PALAQDWGLSPAQLGpvGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 113 GIGLIPSYETIGLWapilllivKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAATVALITHAVG 192
Cdd:cd17365 80 LTAFAQSVLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLM----FCGYPLGAALGGFLAAALI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 193 EArfaeWGWRIPFFL-ALPLGIIGLYLRNRLeetpvyqqhseqqaqkskpqkfsfkeifvkhkrSLLVCIGLVIstnVTY 271
Cdd:cd17365 148 PA----FGWRSVFLLgGVPPLILLPLLRGTL---------------------------------LLWVTFFMGL---LLV 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 272 YMLLTYLPSYFSHNlGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRP----FIFIGSFSLIFLSYPAFVLLnsgvn 347
Cdd:cd17365 188 YLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRvlalFFALGAVSLALLGVSPASLV----- 261
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 348 yQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLV 407
Cdd:cd17365 262 -LLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLL 320
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
82-442 |
1.99e-15 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 78.52 E-value: 1.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYT--------VFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFgsiaGFVLGAATVALITHAVgearfAEWGWrIPFFLALPLGIIGLY------------LRNRLEETPVYQ 229
Cdd:TIGR00898 214 RAIVGTLIQV----FFSLGLVLLPLVAYFI-----PDWRW-LQLAVSLPTFLFFLLswfvpesprwliSQGRIEEALKIL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 230 QH----------------SEQQAQKSKPQKFSFKEIFVKHK--RSLLVCIGLVISTNVTYYMLLtylpsyfshnLGYSEA 291
Cdd:TIGR00898 284 QRiakingkklpaevlslSLEKDLSSSKKQYSFLDLFRTPNlrKTTLCLMMLWFTTAFSYYGLV----------LDLGNL 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 292 HGALIIIAVMVGML-FVQPVIGYLS-DKFGRRP------FIFIGSFSLIFLSYPAFVLLNSGVnyqIFIGLLILALSLNM 363
Cdd:TIGR00898 354 GGNIYLDLFISGLVeLPAKLITLLLiDRLGRRYtmaaslLLAGVALLLLLFVPVDLYFLRTAL---AVLGKFGITSAFQM 430
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 364 sigVMASTlPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATlveTTHNLMVPAYYLMICGVVGIATAMYLKETANKPL 442
Cdd:TIGR00898 431 ---VYLYT-AELYPTVVRNLGVGVCSTMARVGSIISPFLVYL---GEKWLFLPLVLFGGLALLAGILTLFLPETKGVPL 502
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
26-236 |
2.13e-15 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 78.62 E-value: 2.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 26 KAITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVpFIFRPLGGLFFGHLGDKYGRQKVLAITVI 105
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVSAAVNGSA-SIGTLAGQLFFGWLADKLGRKRVYGMELI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 106 IMSISTFGIGLIPSYETIGLWApiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRG-FMGSWLDFgsiAGF-VLGAAT 183
Cdd:TIGR00887 95 IMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGaMMAAVFAM---QGFgILAGAI 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447183265 184 VALITHAVGEARF----------------AEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQ---QHSEQQA 236
Cdd:TIGR00887 170 VALIVLAGFKHSLeaaadeasctgscvpaVDYMWRILIGFGAVPALLALYFRLTIPETPRYTadvAKDVEQA 241
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
31-443 |
2.64e-15 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 78.15 E-value: 2.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 31 AALGNAIEWFDFGVYG--YVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMS 108
Cdd:TIGR00879 33 AAIGGLMFGYDTGVIGgaLALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 109 ISTFGIGLIPsyetiGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGS----WLDFGSIAGFVLGAATV 184
Cdd:TIGR00879 113 IGAILMGLAA-----FALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSlyqlAITFGILVAYGFGSGKV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 185 ALIThavgearfaEWGWRIPFFLALPLGIIGL-----------YL-----------------------RNRLEETPVYQQ 230
Cdd:TIGR00879 188 SLNN---------TLGWRIPLGLQLIPAGLLFlglfflpesprWLvgkgrveearkslarlrgtsgedKELLDELELIDI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 231 HSEQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVM-VGMLFVQP 309
Cdd:TIGR00879 259 KRSIEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGaVNFAFTFV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 310 VIgYLSDKFGRRPFIFIG-------SFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPA-LFPTEIR 381
Cdd:TIGR00879 339 AI-FLVDRFGRRPLLLIGaagmaicLFVLGILGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSeIFPLSLR 417
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447183265 382 YSALGIAFN----FSVVIAGLTPTLTATLvettHNLMVPAYYLMICGVVGIATAMYLKETANKPLI 443
Cdd:TIGR00879 418 PKGISIAVAanwlANFIVGFLFPTMLESI----GVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLE 479
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
65-440 |
3.72e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.12 E-value: 3.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 65 QMIAALATFSVPFIfrpLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGG 144
Cdd:COG0738 44 QAGLLLFAFFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 145 EYSGAAIFVAEYSPDRKRGFMgSWLD-FGSIAGFVLGAATVALITHAVGEArfaewgWRIPFFL--ALPLGIIGLYLRNR 221
Cdd:COG0738 113 LDVAANPYVAALGPETAASRL-NLLHaFFSLGALLGPLLGGLLILLGLSLS------WHLPYLIlaVLLLLLALLFLRSK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 222 LEETpvyqqhsEQQAQKSKPQKFSFKEIFvKHKRSLLVCIGLVISTnVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVM 301
Cdd:COG0738 186 LPEI-------EEEEEEAAGSAASLKSLL-KNPRLLLGGLAIFLYV-GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 302 VGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLsypAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEiR 381
Cdd:COG0738 257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG---LLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-T 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 382 YSALGIAFNFSVVIAGLTPTLTATLVETThNLMVPAYYLMICGVVGIATAMYLKETANK 440
Cdd:COG0738 333 AAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
30-393 |
8.45e-14 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 72.61 E-value: 8.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 30 AAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQ--MIAALATFSVpfifrpLGGLFFGHLGDKYGRQKVLAITVIIM 107
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQglVVSSLLLGAA------IGSLFGGPLADRFGRRKSLLIAAVLY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 108 SISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGS----WLDFGSIAGFVLGAAT 183
Cdd:cd17315 75 VIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTlnqlMITFGILLAYLLGLAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 184 VALIThavgearfaeWGWRIPFFLALPLGIIGLYLRNRLEETPVyqqhseqqaqkskpqkfsfkeifvkhkrsLLVCIGL 263
Cdd:cd17315 147 SLSPP----------GWWRLMFALAAVPALLQLLLMFFLPESRA-----------------------------LLVGVGL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 264 VIST-----NVTYYmlltYLPSYFShNLGySEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIG----SFSLIFL 334
Cdd:cd17315 188 QLLQqltgiNAVMY----YAPTIFK-SAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGfagmAASLLLL 261
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447183265 335 SYPAFVLLNS-GVNYQIFIGLLILALSLNMSIGVMASTL-PALFPTEIRysALGIAFNFSV 393
Cdd:cd17315 262 AIAFLLPALAkAAGWLALLGILLYIAAFAMGAGPVPWLLlSEIFPLRIR--GKGMAIATLV 320
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
82-434 |
7.47e-13 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 69.53 E-value: 7.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFgsiaGFVLGAATVALITHAVGEARFAEWGWRIPFFLALPLgiiglylrnrleetpvyqqhseqqaqkskp 241
Cdd:cd17317 112 RSFVGILFGL----FWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLL------------------------------ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 242 qkfsfkeIFVKHKRSLLVCIgLVISTNVTYYMLLTYLPS---YFSHNLGYSeahGALIIIAVMVGMLFVqpvigylsDKF 318
Cdd:cd17317 158 -------LWWLPRRTIIVGL-IWFVTSLVYYGLSLNSSNlggNLYLNFFLS---GLVEIPAYFLALLLL--------DRL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 319 GRRPfIFIGSFSLIFLS-YPAFVLLNSGVNYQIfigllILALSLNMSIGVMASTLPA----LFPTEIRYSALGIAFNFSV 393
Cdd:cd17317 219 GRRW-TLSGSLLLAGLAcLVTALLPDDENTLAL-----TLALVGKFAISAAFSVIYLytaeLYPTVVRNTGVGLCSTVAR 292
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 447183265 394 VIAGLTPTLTATlveTTHNLMVPAYYLMICGVVGIATAMYL 434
Cdd:cd17317 293 VGAILAPFIVLL---GKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
68-434 |
8.53e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 69.95 E-value: 8.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 68 AALATFSVPFIfrpLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETIGLWAP-ILLLIVKIVQGFSIGGEY 146
Cdd:cd06173 38 LVLAAFFLPFL---LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLlVLAFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 147 SGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAVGEArfaewgwrIPFFLALPLGIIGLYLRNRLEETP 226
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA--------INALSFLLSALLLLFIRRPPPAAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 227 vyqqhseqqAQKSKPQKFSFKEIF--VKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGM 304
Cdd:cd06173 187 ---------GESSSLLLRDLREGLryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 305 LFVQPVIGYLSDKFGRRPFIFIGSFsLIFLSYPAFVLLNSGvnYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSA 384
Cdd:cd06173 258 LLGALLLGRLSKRRRRGRLLLIGAL-LLGLALLVLGLSPSL--WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 447183265 385 LGIAFNFSVVIAGLTPTLTATLVETTHnlmvPAYYLMICGVVGIATAMYL 434
Cdd:cd06173 335 FSVYNALNSGAMPLGALLAGLLADALG----LSAVFLLAGALLLLAALLL 380
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
82-434 |
9.64e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 69.53 E-value: 9.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17320 49 LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSVVARAIVRDLYSGAE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 R----GFMGSWLDFGSIAGFVLGAATVALithavgearfaeWGWRIPF-FLALPLGIIGLYLRNRLEETPVYqqhseqQA 236
Cdd:cd17320 121 LakifSLLMMILAIAPALAPLLGGLLLLF------------FGWRAIFvFLALLGLLLLLLVLLFLPETLPE------EK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 237 QKSKPQKF--SFKEIFvKHKRSL--LVCIGLVISTNVTYYMLLTYLpsYFSHnLGYSEAHGALIIIAVMVGMLFVQPVIG 312
Cdd:cd17320 183 RKPLLSSLlrAYKRVL-KNRRFLgyALALGLSFAGLFAYLAAAPFI--YIEQ-LGLSPAQFGLLFALNAIALILGSLLNG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 313 YLSDKFGRRPFIFIGSFSLIF--LSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPtEIRYSALGIAFN 390
Cdd:cd17320 259 RLVRRFGPRRLLRLGLLLLLAaaLVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGF 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 447183265 391 FSVVIAGLTPTLTATLVETTHNLMvPAYYLmICGVVGIATAMYL 434
Cdd:cd17320 338 LQFLIGALAGALVGLLPNGTALPM-GLLIL-VLGLLALLLLILL 379
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
88-375 |
2.32e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 68.37 E-value: 2.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 88 GHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGS 167
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 168 WLDFGSIAGFVLGAATVALITHAvgearfaeWGWRIPFFLALPLGIIGLYLrnrleeTPVYQQHseqqaqkskpqkfsfk 247
Cdd:cd17503 124 LVGLVILLAPAIGPTLGGWLTDN--------LSWRWIFYINLPIGILALLL------APLLDLR---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 248 eIFvKHKRSLLVCIGLVISTnVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIG 327
Cdd:cd17503 174 -LF-KDRNFTLGLLLSFLLG-LGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 447183265 328 sFSLIFLSYPAFVLLNSGVNYQIFIGLLILaLSLNMSIGVMASTLPAL 375
Cdd:cd17503 251 -LLLLALGTLLLAFLTPDTSLWLIILPLFI-RGLGMGLVFMPLNTLAL 296
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
82-442 |
4.33e-12 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 67.76 E-value: 4.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFGSIAGFVLGAATVALITHAVgearfaeWGWRIPFFLALPLGII---GLYlrnRLEETPVYQQhseqqaqk 238
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAAPPALLlgiGMW---FLPPSPRWQG-------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 239 skpqkfsfkeifvKHKRSLLVCIGLVISTNVT-YYMLLTYLPSYFShNLGYSeAHGALIIIAVMVGM--LFVQPVIGYLS 315
Cdd:cd17362 188 -------------NYRKPLIIGLGLVLFQQITgQPSVLYYAATIFK-SAGFS-AASDATLVSVGLGVfkLLMTIVAVLLV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 316 DKFGRRPFIFIG------SFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMA-STLPALFPTEIRYSALGIA 388
Cdd:cd17362 253 DKLGRRPLLLGGvsgmvvSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQISFGPISwLMVSEIFPLRVRGRAIALA 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447183265 389 --FNFsvvIAGLTPTLT-ATLVETthnLMVPAYYLmICGVVGIAT----AMYLKETANKPL 442
Cdd:cd17362 333 vlVNF---GSNALVSLAfLPLQEL---IGLPGTFL-GFGVIGVLAllfiYFTVPETKGLSL 386
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
73-434 |
4.68e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.68 E-value: 4.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetigLWAPILLLIVkiVQGFSIGGEYSGAAIF 152
Cdd:cd17355 44 FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS-----LWQLYLLWGL--LGGGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 153 VAEYSPDRKRGF-MGSWLDFGSIAGFVLGAATVALITHavgearfaeWGWRIPF-----FLALPLGIIGLYLRNRLEET- 225
Cdd:cd17355 117 VAAWWFERRRGLaLGILTAGGGLGSLVFLPLGAALIEA---------FGWRTALlvlalLALLVLVPVLLLLRRRPADLa 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 226 -PVYQQHSEQQAqkskpqKFSFKEIFvKHKRSLLVCIGLvISTNVTYYMLLTYLPSYFSHnLGYSEAHGALIIIAVMVGM 304
Cdd:cd17355 188 lRAYDDASPASP------GSTLKEAL-RSASFWLLALAF-FLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 305 LFVQPVIGYLSDKFGRRPFIFIGSFS-------LIFLSYPAFVLLNSGVnyqiFIGLLILALslnmsIGVMASTLPALFP 377
Cdd:cd17355 259 IVGRLLSGWLGDRYSPRRLLAASYALralglalLLLLPFPPLALLLFAA----LFGLGWGAT-----VPLTAALAARYFG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447183265 378 TEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYL 434
Cdd:cd17355 330 ARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
85-390 |
4.75e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 67.20 E-value: 4.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 85 LFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKR-- 162
Cdd:cd17502 48 PIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERgk 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 163 --GFMGSWLDFGSIAGFVLGAAtvalithavgearFAE-WGWRIPFFLALPLGIIGLY-LRNrleetpvyqqhseqqaqk 238
Cdd:cd17502 120 yqGYIGAVFGIASVAGPLIGGA-------------FTDhLSWRWCFYINLPIGGLALAlLRT------------------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 239 skpqkfsfkeifvkhkrSLLVCIGLVISTnVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKF 318
Cdd:cd17502 169 -----------------ILLSSIFGFLFG-GALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKT 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447183265 319 GRRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILaLSLNMSIGVMASTLPALFPTEIRYSALGIAFN 390
Cdd:cd17502 231 GRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLIL-LGLGLGIGFQQPLVAVQNAVPPADVGVATATN 301
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
84-392 |
7.88e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.88 E-value: 7.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 84 GLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFsigGEYSGAAI---FVAEYSPDR 160
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--------WQLLLFRALVGI---GEASYSPIaptIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 161 KRGFMGSWLDF----GSIAGFVLGaatvALITHAVGearfaewGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHSEQQA 236
Cdd:cd17328 120 KRTRALGVFYFaiplGSGLGYVVG----GLVAQATG-------GWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 237 QKSKPQKF--SFKEIFvKHKRSLLVCIGLVISTNVTyYMLLTYLPSYFSHNLGYSE--------AHGALIIIAVMVGMLF 306
Cdd:cd17328 189 AKSTATSFlaDLKALA-KNPSFILSTLGFTAVSFVT-GALAFWAPTFFLRAFGVGDlssadvglIFGAITCIAGVLGVLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 307 VqpviGYLSDKFGR-----RPFI-FIGSFSLIFLSYPAFVL--LNSGVNYqIFIGLLILALSLNMSIgVMASTLPALFPT 378
Cdd:cd17328 267 G----GILADRLRRktpraDPLVcAVGLLAAAPFLFLALVLalSNLLLAW-VLLFLGEFLLSLNWAP-VFAILLYVVIPT 340
|
330
....*....|....
gi 447183265 379 eIRYSALGIAFNFS 392
Cdd:cd17328 341 -RRSTASAIQILLS 353
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
83-388 |
9.83e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 66.52 E-value: 9.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 83 GGLFFGHLGDKYGRQKVLaitviIMSISTFGiglIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKR 162
Cdd:PRK11551 66 GALLGGRLADRIGRKRIL-----IVSVALFG---LFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 163 GFMGSWLdfgsIAGFVLGAATVALITHAVGEARfaewGWRIPFFL--ALPLGIIGLYLRnRLEETPVYQQHSEQQAQKSk 240
Cdd:PRK11551 138 GTAVSLM----YCGVPFGGALASVIGVLAAGDA----AWRHIFYVggVGPLLLVPLLMR-WLPESRAFAQAAGAGKQRA- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 241 pqkfSFKEIFVKHKRSlLVCIGLVIS---TNVTYYMLLTYLPSYFSHNlGYSEAHGALIIIAVMVGMLFVQPVIGYLSDK 317
Cdd:PRK11551 208 ----PVLRALFGEGRA-TATLLLWISyffTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIGALMDR 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447183265 318 FGRRPFIfIGSFSLIFLSYPAFVLLNSgvnyqiFIGLLILALSLNMSIGVMASTL----PALFPTEIRYSALGIA 388
Cdd:PRK11551 282 LRPRRVV-LLIYAGILASLAALAAAPS------FAGMLLAGFAAGLFVVGGQSVLyalaPLFYPTQVRGTGVGAA 349
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
82-429 |
3.34e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.95 E-value: 3.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETIGLWapiLLLIvkivqGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVL---LFLV-----GAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGF-MGswldfgsI--AGFVLGAATVALITHAVGEARfaewGWRIPFFLALPLGIIG---LYLRNRLEETPVYQQHSEQQ 235
Cdd:cd17475 118 RGLaMG-------IrqTGVPLGGALAAALLPPLALHY----GWRAAFVVAGLVSILAavlFWLFYREPPAASAATESAST 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 236 AQKSKPQKFSFKEIfvkhKRSLLVCIGLVISTnvtyYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLS 315
Cdd:cd17475 187 LLRSLKEVLRNRDV----WLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 316 DKF--GRRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILalslnmsIGVMASTLPALFPTEIRYSA--------- 384
Cdd:cd17475 259 DRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLIL-------LGLFAIGWNGLYLTLVAESAgpeqagtal 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447183265 385 -LGIAFNFSVVIAGltPTLTATLVETTHNLMVPAYYLMICGVVGIA 429
Cdd:cd17475 332 gLANTINFIGIAIG--PPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
72-431 |
9.63e-11 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 63.39 E-value: 9.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 72 TFSVpfiFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGgeYSGAAI 151
Cdd:cd17331 43 TFSV---LQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVP--------MLFLSRLPSVFMHA--MQAAQM 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 152 FVAEYSPDRKR----GFMGswLDFGsiAGFVLGAATVALITHAVGEarfaewgwRIPFFLALPLGIIGLYLRNRLEETPV 227
Cdd:cd17331 110 VVTDLTDPGERaaalGRLG--LSYG--IGMVVGSFLGGLLTKKFGE--------QAAALVAAVGSLLSIVLVILLIPSNT 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 228 Y-QQHSEQQAQKSKPQKFSFKEI--FVKHKRSLLVCIGLVIS---TNVTYYMLLTYLPSYFshNLGYSEAhGALIIIAVM 301
Cdd:cd17331 178 KsKREKEAKESASPPSVFNLKEIlrLLRLPGVAFLLLVKLLSglpIGMFQSMFSLVAMDFF--GLTPEEN-GYLMSYAGV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 302 VGMLFVQPVIGYLSDKFGRRpFIFIGSFSLIFLSYPAFVLLNSgvNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIR 381
Cdd:cd17331 255 LGMVVQGLLVGPLTKRFGER-SLLKLSVALLAIGYLLLAFVTT--VWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDT 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 447183265 382 YSALGIAFNFSVVIAGLTPTLTATLVettHNLMVPAYYLMICGVVGIATA 431
Cdd:cd17331 332 GTALGLSHALFSLVRTVSPTIGGALL---QAYGFPSFGLLGAAINGLLTV 378
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
74-442 |
1.05e-10 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 63.36 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 74 SVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFV 153
Cdd:cd17358 48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVW--------MLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 154 AEYSPDRKRGFMGS----WLDFGSIAGFVLGA----ATVALITHAVgearfaewgwRIPFFLALP--------LGIIGL- 216
Cdd:cd17358 120 AEIAPKNVRGALGSlnqlLVNIGILLGYVLGSflpwRTLALIGAIP----------PVVFLILLFfipesprwLAKKGRe 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 217 --------YLRNR-------LEETPVYQQHSEQQAQKSKPQKFSFKEIFvkhkRSLLVCIGLVI------STNVTYYMLl 275
Cdd:cd17358 190 eeaekslqFLRGKdadiskeAAEIQEELAELEKEAKESSFSDLFQRKYL----KPLVIGLGLMLfqqlsgINAVIFYAS- 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 276 tylpSYF-SHNLGYSEAHGALIIIAVMVGMLFVQPVigyLSDKFGRRP-------FIFIGSFSL-IFLSYPAFVLLNSGV 346
Cdd:cd17358 265 ----SIFdEAGSGLDPNTATIIIGVVQVVGTLVATL---LVDRLGRRPlllvsaiGMGIGLLALgLYFYLQEHGALLSSV 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 347 NYQIFIGLLILALSLNMSIG----VMASTLpalFPTEIRYSALGIAFnfsvviagLTPTLTATLVETTHNLMVPAYYL-- 420
Cdd:cd17358 338 SWLPLVGLVIYIISFSIGLGplpwVIMSEI---FPAKIKGLAGSLVT--------LVNWLFAFIVTKTFPFLTLAWGAsg 406
|
410 420
....*....|....*....|....*...
gi 447183265 421 ------MICGVVGIATAMYLKETANKPL 442
Cdd:cd17358 407 tfwifaGICGLALVFVLLFVPETKGKSL 434
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
85-412 |
1.55e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.60 E-value: 1.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 85 LFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKR-- 162
Cdd:cd17504 49 PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--------LIAGRALQGIGGAVFPLAFALVREEFPPERVPva 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 163 -GFMGSWLDFGSIAGFVLGAATVALithavgearfaeWGWRIPFFLALPLGIIGLYLrnrleeTPVYqqhseqqaqksKP 241
Cdd:cd17504 121 qGILSATFGIGAGIGLPLGGWIVQH------------LGWRWIFWTAAPVAVLLAAL------VPLI-----------DL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 242 QKFSFKEIFVKHKRSLLVCIGLVIstnvTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRR 321
Cdd:cd17504 172 RLLRRRNVLLANITALLAGFGMFM----VFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 322 PFIFIGSFsLIFLSYPAFVLLNSGVnYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPT 401
Cdd:cd17504 248 RVLLIGLV-ISAVGLLLLALLHSSL-WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPA 325
|
330
....*....|.
gi 447183265 402 LtATLVETTHN 412
Cdd:cd17504 326 I-AGAILTTYT 335
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
74-357 |
1.79e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 62.58 E-value: 1.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 74 SVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglwaPILLLIVKIVQGFSIGGEYSGAAIFV 153
Cdd:cd17477 38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 154 AEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAvgearfaewGWRiPFFLA---LPLGIIGLYLRNRLeetpvyqq 230
Cdd:cd17477 110 NALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA---------GAL-PFLIAavlLLLALVPLLLTRRA-------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 231 hseqQAQKSKPQKFSFKEIFVKHKRSLLVCI--GLVISTnvtyymLLTYLPSYFSHnLGYSEAHGALIIIAVMVGMLFVQ 308
Cdd:cd17477 172 ----APEIEEAESISLRRLLRIAPLALLGAFvaGFLEGA------FYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 447183265 309 PVIGYLSDKFGRRPFIFIGSFSLIFLSypAFVLLNSGVNYQIFIGLLIL 357
Cdd:cd17477 241 WPLGWLADRFDRRRVLLGCALLGALAA--LLLPLVPGLPLALLVLLFLW 287
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
71-440 |
3.22e-10 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 61.89 E-value: 3.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 71 ATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGL---IPSYEtiglwapiLLLIVKIVQGFSIGGEYS 147
Cdd:cd17357 53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLsksAKSPE--------LLIFGRFLVGIACGLSTG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 148 GAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAatVALITHAVGearfAEWGWRIPFFLALPLGIIGL----------- 216
Cdd:cd17357 125 FVPMYLQEISPSELRGALGSLTQIGVTLGILLGQ--VFGLPSVLG----TETLWPYLLFFPGIPALLQLaalpffpespk 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 217 -----------------YLRNRL-EETPVYQQHSEQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVIST-------NVTY 271
Cdd:cd17357 199 flliskgdeeeaekslkFLRGIEdDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVSAsqqfsgiNAIF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 272 YmlltYLPSYFShNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFS----LIFLSYPAFVLLNSGVN 347
Cdd:cd17357 279 F----YSTFIFE-NAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVcavaLLLMSVFLFLSEQNSWM 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 348 YQIFIGLLIL-ALSLNMSIGVMASTLPA-LFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETthnlmVPAYYLMICGV 425
Cdd:cd17357 354 SYGCIVAIFLfIFFFAIGLGPIPWFIGAeLFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSI-----GGGFVFIIFAI 428
|
410
....*....|....*....
gi 447183265 426 VGIATA----MYLKETANK 440
Cdd:cd17357 429 PCALFLlylyRYLPETKGR 447
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
42-333 |
3.27e-10 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 61.87 E-value: 3.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 42 FGVY-GYVAYVLGKVFFPDASPSVQMIAALAT------FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGI 114
Cdd:cd17345 6 LGIFiGYAGYYLVRNNFSLAQPYLIEQYGLSKteigliGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 115 GLIPSYETIGLWAPILLLIVKIVQGFSiggeYSGAAIFVAEYSPDRKRGFmgsWLDFGSIAGFVLGAATVALIthAVGEA 194
Cdd:cd17345 86 GFVPSATSSVGLMFILLFLNGWFQGMG----WPPSGRTMVHWFSKKERGT---WTSIWNISHNVGGGLVGPLA--GLGLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 195 RFAEWGWR----IPFFLALPLGIIGLYLR---------NRLEETpvYQQHSEQQAQKSKPQKFSFKEIFVKH----KRSL 257
Cdd:cd17345 157 IFGDGWWRgafiFPAIIAIIVAVIVLFLGkdtpeseglPPIEEY--KGDYPEEADGEEEEQELSAWEIFVKYvlknKLLW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 258 LVCIglvisTNVTYYML----LTYLPSYFSHNLGYSEAHGALII----IAVMVGMLfvqpVIGYLSDKF--GRRPFIFIG 327
Cdd:cd17345 235 YIAI-----ANVFVYLVrygiLDWAPTYLSEVKGFSKAQAMWAFslfeWAAIPGTL----LAGWLSDKLfkGRRAPTGII 305
|
....*.
gi 447183265 328 SFSLIF 333
Cdd:cd17345 306 FMILVI 311
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
254-437 |
7.69e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.37 E-value: 7.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 254 KRSLLVCIGLVISTNVTYYMLLTYLPSYfSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPfIFIGSFSLIF 333
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR-VLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 334 LSYPAFVLLNSGvnYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNL 413
Cdd:COG2814 87 LGSLLCALAPSL--WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180
....*....|....*....|....
gi 447183265 414 MVPAYYLMICGVVGIATAMYLKET 437
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPES 188
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
64-376 |
8.15e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 60.67 E-value: 8.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 64 VQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIG 143
Cdd:cd17323 31 VSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAM--------LIILRFLQGFFGS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 144 GEYSGAAIFVAEYSPDRKRG-FMGSWldfgsIAGFVLGAATVALITHAVGEArfaeWGWRIPFFLalpLGIIGLylrnrl 222
Cdd:cd17323 103 SPLAIGAGTIADLFTPEERGkAMGVY-----SLGPLLGPALGPIIGGFITQS----LGWRWIFWF---LAIISG------ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 223 eetpvyqqhseqqaqkskpqkFSFKEIFVKHKRSLLVCIGLVIStNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMV 302
Cdd:cd17323 165 ---------------------FCLILIFLFLPIVLLLGLYVGLV-YAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGI 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 303 GMLFVQPVIGYLSDKFGRR-----PFIFIGSFSLIFLSYPAFVLLnsgvnyqifIGLLILALSLNMSIGVMASTLPALF 376
Cdd:cd17323 223 GALIGSIIGGRLSDYYYRRlkkknGGKPEPEARLPPAFIGAFLFP---------IGLFIFGWTIYPHIHWIVPIIGSAF 292
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
270-434 |
1.76e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.35 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 270 TYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGsfsLIFLSYPAFVLLNSGVNYQ 349
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 350 IFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVEtthNLMVPAYYLMICGVVGIA 429
Cdd:pfam07690 88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS---LFGWRAAFLILAILSLLA 164
|
....*
gi 447183265 430 TAMYL 434
Cdd:pfam07690 165 AVLLL 169
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
82-442 |
2.05e-09 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 59.71 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFG-----IGLIPSYE-TIGLWapILLLIVKIVQGFSIGGEYSGAAIFVAE 155
Cdd:PRK10077 70 IGGALGGYCSNRFGRRDSLKIAAVLFFISALGsawpeFGFTSIGPdNTGYV--PEFVIYRIIGGIGVGLASMLSPMYIAE 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 156 YSPDRKRGFMGSWLDFGSIAGFVLgaatVALITHAVGEARFAEW----GWRIPFFL-ALPLGIIGLYLRNrLEETPVY-- 228
Cdd:PRK10077 148 IAPAHIRGKLVSFNQFAIIFGQLV----VYFVNYFIARSGDASWlntdGWRYMFASeAIPALLFLMLLYF-VPETPRYlm 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 229 QQHSEQQAQ--------KSKPQ------KFSFKEIFVKHKR-----SLLVCIGLVIST-------NVTYYmlltYLPSYF 282
Cdd:PRK10077 223 SRGKQEQAEgilrkimgNTLATqalqeiKHSLDHGRKTGGKllmfgVGVIVIGVMLSVfqqfvgiNVVLY----YAPEIF 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 283 ShNLGYSEAHGAL-IIIAVMVGMLFVQPVIgYLSDKFGRRPFIFIGSFSL-IFLSYPAFVLLNSGVNYQIFIGLLILALS 360
Cdd:PRK10077 299 K-TLGASTDIALLqTIIVGVINLTFTVLAI-MTVDKFGRKPLQIIGALGMaIGMFSLGTAFYTQAPGIVALLSMLFYVAA 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 361 LNMSIGVMASTLPA-LFPTEIRYSALGIA------FNFsvVIAGLTPTL--TATLVETTHNLMvpAYYLMicGVVGIATA 431
Cdd:PRK10077 377 FAMSWGPVCWVLLSeIFPNAIRGKALAIAvaaqwiANY--FVSWTFPMMdkNSWLVAHFHNGF--SYWIY--GCMGVLAA 450
|
410
....*....|....*
gi 447183265 432 MYL----KETANKPL 442
Cdd:PRK10077 451 LFMwkfvPETKGKTL 465
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
30-385 |
2.02e-08 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 56.16 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 30 AAALGNAIEWFDFGVYG--YVAYVLGkvffpdASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQK-VLAITVII 106
Cdd:pfam13347 4 SGALAAGIKYAGLATYLlyFYTDVLG------LSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRpWLLLSAII 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 107 MSISTFGIGLIPSYETIGL--WAPILLLIVKIVQGFSIGGEYSgaaiFVAEYSPDRK-RGFMGSWLDFGSIAGFVLGAA- 182
Cdd:pfam13347 78 LAVSFILLFTPPELGRAPLfiWLLATYILLRIAYTFFEIPYWS----LGPELTRDYDeRTSLTSYRSFFSVGGGLLAAAl 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 183 --TVALITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRleETPVYQQHSEQQAQKSKPQKFSFKEIFvkHKRSLLVC 260
Cdd:pfam13347 154 afPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTK--ERVSMRSKEDTGQKEAGSLLDMLKEVF--RNRAFLIL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 261 IGLVISTNVTYYMLLTYLPSYFSHNLGySEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSypAFV 340
Cdd:pfam13347 230 LASFLLAALAMGVLNGLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGF--ALA 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 447183265 341 LLNSGVNYQIFIGLLILAlslNMSIGVMASTLPALFPTEIRYSAL 385
Cdd:pfam13347 307 LLLGPNNTLLFLVLYIII---GFGYGSSFFLPWSMLADVVDYGEL 348
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
63-340 |
2.80e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 55.73 E-value: 2.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 63 SVQMIAALAtFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFsI 142
Cdd:cd17391 33 LVELWSGLA-FSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGV-F 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 143 GGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGaatvALITHAVGEArfaeWGWRIPFFLALPLGIIGLYLrnrl 222
Cdd:cd17391 103 SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIG----PLLGGFLADL----FGIRNVFFITGGLLFLAFLL---- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 223 eetPVYQQHSEQQAQKSKPQKfSFKEIF--VKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHnLGYSEAHGALI---I 297
Cdd:cd17391 171 ---TLFFVKEDFKPVEKKKMV-STKEVWnsVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQ-LMGDASNLAFIsglV 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 447183265 298 IAVM-VGMLFVQPVIGYLSDKFGRRPFIFIGS-FSLIFLSYPAFV 340
Cdd:cd17391 246 FSATgVSSLLSAPRLGKLGDRIGHHRILLGALlASALLYIPQAFV 290
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
259-441 |
7.22e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 7.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 259 VCIGLVIStNVTYYMLLTYLPSYFSHnLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFsLIFLSYPA 338
Cdd:cd17325 1 LSLALFLD-MLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLL-LLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 339 FVLLNSGvnYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHnLMVPAY 418
Cdd:cd17325 78 FAFATSY--WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFL 154
|
170 180
....*....|....*....|...
gi 447183265 419 YLMICGVVGIATAMYLKETANKP 441
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPP 177
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
85-358 |
7.89e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 54.23 E-value: 7.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 85 LFFGHLGDKYGRQKVLAITVIIMSISTFGIGLI-PSYETiglwapilLLIVKIVQGFSiGGEYSGAAIFVAEYSPDRKRG 163
Cdd:TIGR00886 55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSV--------LLLIRLFIGIA-GGSFASCMPWISFFFPKKIQG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 164 ----FMGSWLDFG-SIAGFVLGAATVALITHAVGEARFAeWGWRIPFFLALPLGIIGLYLRNRLEETPvyqqhseqqAQK 238
Cdd:TIGR00886 126 talgLAAGWGNMGgGVAQFVMPPIIGSLIFGGGQPAHLA-WGWAFVIVPAGILLLPALLIFFVGADTP---------PGK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 239 SKPQKFSFKEIFV--KHKRSLLVCIgLVISTNVTYYMLLTYLPSYFSHNLGYSEAH-GALIIIAVMVGmLFVQPVIGYLS 315
Cdd:TIGR00886 196 PATGKLSFKEALKvfGNRHTWILAL-LYSVTFGSFLGVSSIFAMLFKDQFGLSKVQaGAYASLGGFLG-SLARPAGGAIS 273
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 447183265 316 DKFGRRPfIFIGSFSLIFLSYPAFVL-LNSGVNYQIFIGLLILA 358
Cdd:TIGR00886 274 DRLGGAR-KLLMNFLGVAMGAFLVVLgLVSDGSLAAFIVLFVAL 316
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
73-361 |
9.36e-08 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 54.36 E-value: 9.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFgigLIPSYETIGLwapILLLIVKIVQGFSIGGEYSGAAIF 152
Cdd:TIGR00894 82 LSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISI---VIPWAAGGGI---ALVVFCRVIQGLAQGSVSPATHKI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 153 VAEYSPDRKRGFMGSwldfGSIAGFVLGAATVALIThavGEARFAEWGWRIPFFLALPLGI---------------IGLY 217
Cdd:TIGR00894 156 IVKWAPPKERSRLLG----MSTSGFQLGTFIFLPIS---GWLCESWGGWPMIFYVFGIVGCawsllwfvfpaddpsIHPC 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 218 LRNRLEEtpvYQQHSEQQAQKSKPQKFSFKEIFVKhkRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALII 297
Cdd:TIGR00894 229 ISKFEKK---YINSSLQGQKGSTRQSLPIKAIPKS--LPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLS 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 298 IAVMVGMLFVQPVIGYLSD----------KFGRRPFIFIGSFSLIFLSYPA------------FVLLNSGVNYQIFIGLL 355
Cdd:TIGR00894 304 SLPYLFAWLCSIFAGYLADflkssktlslTAARKIFNGIGGLGPGIFAYALpylsaafyltiiILTLANAVSSGPLAGVL 383
|
....*.
gi 447183265 356 ILALSL 361
Cdd:TIGR00894 384 INSLDL 389
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
82-442 |
9.61e-08 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 54.18 E-value: 9.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIImsistFGIGLIPSYETIGLWApiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVI-----YIIGAIIQVAAIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFGSIAGFVLGAATVaLITHavgeARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQhseqqaqkskp 241
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAYCIN-YGTH----KLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWLY----------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 242 qkfsfkeifvkhkRSLLVcIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHG---ALIIIAVMVGMLFVQPvigYLSDKF 318
Cdd:cd17356 197 -------------RTILG-IMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPlltSIILYIVNFVSTIPGL---FFVDKF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 319 GRRPFIFIGSFS-LIFLSYPAFVL-------------LNSGVNYQIFIGLLILAlSLNMSIGVMASTLPA-LFPteIRYS 383
Cdd:cd17356 260 GRRTCLLIGAAGmSICLFIYAAVGvrylipnpqsgtsNKSAGNGMIVFICLFIF-SFATTWGPIAWVYVAeVFP--LRVR 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 384 ALGIAFNFSV------VIAGLTPTLTATLvetthnlmvPAYYLMICGVVGIATAMY----LKETANKPL 442
Cdd:cd17356 337 SKGMALATAFnwlwnfLISFFTPFIIGSI---------GFKYYYIFAGCNLLAFIVvfffVPETKGLTL 396
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
82-430 |
1.01e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.16 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglwaPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--------PWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFGSIAGFVLGAATVALITHAVGEARFAewgwrIPFFLALPLGIIGLYLRNRLEETpvyqqhseQQAQKSKP 241
Cdd:cd17329 122 RTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFL-----AAAVLFLLAALVLLFLLPETRPK--------RRAAEKTE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 242 QKFSFKeIFVKHKRSLLVCIGLVISTnVTYYMLLTYLPSYFSHNLGYSE-AHGALIIIAVMVGMLFvQPVIGYLSDKFGR 320
Cdd:cd17329 189 ILRGYK-IVLRDRAFLLFLLASFLIS-LIYFQLESTLPVYVVEILGLGEsLLGLLLALNALLIVLL-QFPVARLVERFRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 321 RPFIFIGsfsLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIR---YSALGIAFNFSVVIAG 397
Cdd:cd17329 266 RKILMIG---ILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRgsyMGFYALAWGLGRAIGP 342
|
330 340 350
....*....|....*....|....*....|...
gi 447183265 398 ltptLTATLVETTHNLMVPAYYLMICGVVGIAT 430
Cdd:cd17329 343 ----LVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
88-414 |
1.47e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 53.39 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 88 GHLGDKYGRQKVLAITVIIMSISTFgigLIPSYETIGLWApilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGS 167
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 168 wldfGSIAGFVLGAAtvalITHAVGEARFAEWGWRIPFFLalpLGIIG-----LYLRNRLeetPVYQqhseqqaqkskpq 242
Cdd:cd17318 151 ----IAYSGSQFGTV----IAMPLSGFLCESLGWPSIFYI---FGGLGllwclLWFFLVL---PVWA------------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 243 kfsfkeIFVKHkrsllvciglvISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDK----- 317
Cdd:cd17318 204 ------IVVAH-----------FGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWlrsrg 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 318 -----FGRRPFIFIGSF----SLIFLSYPafvllnsGVNYQIFIGLLILALSLN--MSIGVMASTLpALFPteiRYSA-- 384
Cdd:cd17318 267 ilsttTVRKLFTSIGFLgpgvFLIALGYL-------GSNATLAVVFLTLSVGLSgaCYSGFLVNHL-DLAP---NYAGtl 335
|
330 340 350
....*....|....*....|....*....|
gi 447183265 385 LGIAFNFSVVIAGLTPTLTATLVETTHNLM 414
Cdd:cd17318 336 MGITNTAATIAGIISPLIVGAIVKNDQTIG 365
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
82-428 |
1.73e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 53.05 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17312 53 VGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSL--------WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFGSIAGFVLGAATVALITHAVGearfaewgWRIPFFLALPLGIIG-LYLRNRLEETPVYQQHseqqaqksk 240
Cdd:cd17312 125 RGTVYGIWSTSHNFGGILAPILAASLASYYG--------WRAAFLVPGIVGLVVaIILFFFLRDSPPYVWV--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 241 pqkFSFKEIFVKHKRsllvciglvistnvtyYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGR 320
Cdd:cd17312 188 ---LSLAYAFVYIVR----------------YACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 321 RPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILA-LSLN---MSIGVMASTlpALFPTEIRYSALGIAFNFSVVIA 396
Cdd:cd17312 249 GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIgFFVGgpiNLIGGAAAQ--DIGRKEAAGTATGFVGLFGYLGA 326
|
330 340 350
....*....|....*....|....*....|..
gi 447183265 397 GLTPTLTATLVETTHNLMVpAYYLMICGVVGI 428
Cdd:cd17312 327 SLAGLPLGYIIDHYGWSTV-FYFLISAALLSV 357
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
82-214 |
3.23e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 49.57 E-value: 3.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 447183265 162 RGFMgswldfgsIAGFVLGAATVALITHAVGEARFAEWGWRIPFFLALPLGII 214
Cdd:TIGR00880 85 RGVA--------LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
270-441 |
3.36e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.21 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 270 TYYMLLTYLPSYfSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGsFSLIFLSYPAFVLLNSGVnyQ 349
Cdd:cd17489 11 SFYLLLPVLPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIG-LLIFALATLLYLLATSVA--L 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 350 IFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETThNLMVPAYYLMICGVVGIA 429
Cdd:cd17489 87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLFIVAAVLALLALL 165
|
170
....*....|..
gi 447183265 430 TAMYLKETANKP 441
Cdd:cd17489 166 LVFLVKDPPPVA 177
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
66-427 |
3.61e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 52.17 E-value: 3.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 66 MIAALATFsVPFIFRPLGGLFFghlgDKYGRQKVLAITVIIMSIstfgiGLIPSYETIGLWapILLLIVKIVQGFSIGGE 145
Cdd:cd17352 42 WIGSLLLG-VSLFSGPLSSALV----NRFGCRPVAIAGGLLAAL-----GLLLSSFATSLW--QLYLTYGVLGGLGLGLI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 146 YSGAAIFVAEYSpDRKRGF-MGSwldfgSIAGFVLGAATVALITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRnrlee 224
Cdd:cd17352 110 YSPAIVIVGQYF-EKKRGLaTGI-----AVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR----- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 225 tpvyqqhseqqaqkskpqkfsfkeiFVKHKRSLLVCIGLVIsTNVTYYMLLTYLPSYFShNLGYSEAHGALIIIAVMVGM 304
Cdd:cd17352 179 -------------------------LLKDPTFVLLALGVSF-AMLGFFVPFVYLPSYAK-SLGIDESDAAFLLSIIGISD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 305 LFVQPVIGYLSDKFG-RRPFIFIGSFSLIFLSYPAFVLLNSGVNyQIFIGLLIlALSLNMSIGVMASTLPALFPTEIRYS 383
Cdd:cd17352 232 IVGRILLGLLADKPRiGRLYLYIFTLLILGLSLLAFPLATTYVG-LIVFSVLF-GFCSGSYSSLTPVILADLVGLEKLSN 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 447183265 384 ALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVG 427
Cdd:cd17352 310 AYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLS 353
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
267-398 |
4.03e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.23 E-value: 4.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 267 TNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLiFLSYPAFVLLNSGv 346
Cdd:cd17329 11 NRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLR-ALGFALLGFAHSP- 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 447183265 347 nYQIFIGLLILALSLNMSIGVMASTLPALFPTEIR---YSALGIAFNFSVVIAGL 398
Cdd:cd17329 89 -WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRtraFSLLYWAINLGVAIGPL 142
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
82-406 |
5.49e-07 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 51.50 E-value: 5.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEV--------LIVGRVLVGLGVGIASMTVPLYIAEAAPPRI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGS----WLDFGSIAGFVLGAAtvalITHAVGearfaewGWRIPFFLALPLGIIGLYLRNRLEETPVYqqhseqqaq 237
Cdd:cd17360 122 RGRLVTinvlFITGGQFVAYVINGA----FSYLPG-------GWRWMLGLAAVPAVLQFIGLLFLPESPRW--------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 238 kskpqkfsfKEIFvkhkRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIG-YLSD 316
Cdd:cd17360 182 ---------PSTR----RALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGmYLID 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 317 KFGRRPFIFIGSF----SLIFLSypAFVLLnsgvnyqIFIGLLILALSLNMsiGVMASTLPA-LFPTEIRYSALGIA--- 388
Cdd:cd17360 249 KFGRRKLLLISLFgvivALVVLA--VWLAL-------VGLILYLAFFAPGM--GPVPWTVNSeIYPLWARGTGGGCAaav 317
|
330
....*....|....*....
gi 447183265 389 -FNFSVVIAGLTPTLTATL 406
Cdd:cd17360 318 nWVFNLLVSQTFLTLTQAI 336
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
167-373 |
6.36e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 51.45 E-value: 6.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 167 SWLDFGSIAGFVLGAATVALITHAVGEaRFAEWGWRIPFFLALPLGIIGLYLR--NRLEETPVyqqhsEQQAQKSKPQKF 244
Cdd:cd17332 139 SWRMFFATIGGLLVTVLPPPLVAYFGG-GNASRGYFLTALIIGIIGIILLLICffGTRERVVP-----PEEEKSKLPLLK 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 245 SFKEIFvkHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGySEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFI 324
Cdd:cd17332 213 SLKALL--KNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAF 289
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 447183265 325 FIGSfSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLP 373
Cdd:cd17332 290 FIGL-LLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA 337
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
85-398 |
3.41e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 85 LFFGHLGDKYGRQKVLAIT-VIIMSISTFGIGLIPSyetiglWAPILLLIVkivqgfsigGEYSGAAI-------FVAEY 156
Cdd:cd17370 52 LFSGYLSDRTGKRKPLVILgYGLSALAKPLLALAGS------WQLVLLLRI---------LERLGKGIrtpprdaLLADA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 157 SPDRKRGFMGSWLDFGSIAGFVLGAATVALIthavgeARFAEWGWRIPFFLALPLGIIGLYLRNRLEETpvYQQHSEQQA 236
Cdd:cd17370 117 TPPSGRGKAFGLHRALDTLGAVLGPLLAALL------LYLLGGNYRTIFLLAAIPALLALLILLFVVKE--YPRPPKLRK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 237 QKSKPQKFSFKEIFVKhkrsLLVCIGLVISTNVTYYMLLTYLpsyfshnlgYSEAHGALIIIAVMVGMLFVQ----PVIG 312
Cdd:cd17370 189 KSKKTSLKKLPKAFWL----YLLAVALFALGNFSFAFLILRA---------QELGLSAALIPLLYALFNLVYalaaYPAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 313 YLSDKFGRRPFIFIGSFSLIFLSypaFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIaFNFS 392
Cdd:cd17370 256 RLSDRIGRKKLLILGYLSLALAY---LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL-FNTV 331
|
....*.
gi 447183265 393 VVIAGL 398
Cdd:cd17370 332 VGIGWL 337
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
82-284 |
6.11e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 48.49 E-value: 6.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWL-DFGSIAGFVLGAATVALITH-----AVGEArFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVY------- 228
Cdd:cd17439 121 RGEHLSWLcMFWMIGGIYASAMAWAIIPHygwsfQMGSA-YQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFflengkh 199
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447183265 229 --------QQHSEQQAQKSKPQK-FSFKEIfvkHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSH 284
Cdd:cd17439 200 deawmvlkQVHDTNMRAKGHPERvFSVTHI---KRRITLMMMAVWFTMSFSYYGLTVWFPDMIKH 261
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
82-199 |
8.76e-06 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 48.43 E-value: 8.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:TIGR01299 217 VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYFAEFLAQEK 288
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 447183265 162 RGFMGSWL-DFGSIAGFVLGAATVALITH-----AVGEA-RFAEW 199
Cdd:TIGR01299 289 RGEHLSWLcMFWMIGGIYAAAMAWAIIPHygwsfQMGSAyQFHSW 333
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
254-438 |
1.06e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.57 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 254 KRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAH-GALIIIAVMVGMLFvQPVIGYLSDKFGRRPFIFIGSFSLI 332
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQlGLLFAIPVLVGALL-RIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 333 FlsypAFVLLNSGVNYQIFIGL-LILALSLNMSIGVMASTLPALFPTEIRYSALGI---AFNFSVVIAGltptLTATLVE 408
Cdd:COG2223 82 I----GLLLLALAVSYWLLLLLgLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLaagGGNLGAAVAA----FLAPLLI 153
|
170 180 190
....*....|....*....|....*....|.
gi 447183265 409 TTHNL-MVPAYYLMICGVVGIATAMYLKETA 438
Cdd:COG2223 154 AAFGWrNAFLILGILLLVVAVLAWLFLRDPP 184
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
254-409 |
1.39e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 254 KRSLLVCIGLVISTNVTYY--MLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFsL 331
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLdrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL-L 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447183265 332 IFLSYPAFVLLNSGVnyQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVET 409
Cdd:COG2271 85 WGLATLLFGFATSFW--QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
268-391 |
2.13e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 46.85 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 268 NVTYYMLLTYLPSYFShNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSD----KFGRR-PFIFIGSFS-----LIFLSYP 337
Cdd:cd17313 12 EFGWALENSYVPPILQ-TLGLSHALIGFVWTLGPILGLFVQPLVGSLSDrcnsRIGRRrPFILVGAPLaalglILIPNAA 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 338 AFVLLNSGVNYQIFIGLLILA-----LSLNMSIGVMASTLPALFPTEIRYSALGIaFNF 391
Cdd:cd17313 91 DIGLALGDGPRTWALVLFVLGivlldFAMNVCQGPVRALLPDLVPPEQRSKANGI-INF 148
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
71-359 |
2.98e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.84 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 71 ATFSVPFIFrplggLFF--GHLGDKYGRQKVLAIT----VIIMSISTFGIGLIPSYetiGLWAPILLLIVKivqgfsigg 144
Cdd:PRK08633 54 ALFLLPFLL-----LSSpaGFLADKFSKNRVIRIVklfeVGLTLLIVLAYYLGWFW---LAFAVTFLLGAQ--------- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 145 eysgAAIF-------VAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAVGEARFAEWG---WRIPFFLaLPLGII 214
Cdd:PRK08633 117 ----SAIYspakygiIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPSEILgriAPAGLVL-LAVAVL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 215 GLYLRNRLEETPvyqqhSEQQAQKSKPQKFSFKEIF-----VKHKRSLLVCI-GLVISTNVTYYMLLTyLPSYFSHNLGY 288
Cdd:PRK08633 192 GLIFAYRLPKVP-----AAAPEVFDKKKYLFPKLLWrnlklLRSDRVLWLAIiGLSYFWFISQLAQAN-FPAYAKEVLGL 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 289 SEAHGALIIIAVM-VGMLFVQPVIGYLSDK---FGRRPF----IFIGSFSLIFLSYPAFVLLNSgVNYQIFIGLLILAL 359
Cdd:PRK08633 266 DNTFQVQYLLAASaIGIGIGSLLAGRLSGRhieLGLVPLgalgLALSLFLLPTAPSLASVLVLF-FLFGFSAGLFIVPL 343
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
82-197 |
3.01e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 46.30 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyeTIGLWAPILLLivkivqGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:COG2270 289 LGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTT--ALAFWILGLLI------GLVMGGIQALSRSLLARLIPPGR 360
|
90 100 110
....*....|....*....|....*....|....*..
gi 447183265 162 RG-FMGSWLDFGSIAGFvLGAATVALITHAVGEARFA 197
Cdd:COG2270 361 EAeFFGLYALSGKAASF-LGPLLFGLVTQLTGSQRLG 396
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
87-392 |
4.56e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 4.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 87 FGHLGDKYGRQKvlaitVIIMSISTFGIGLIPSYETIGLWapiLLLIVKIVQGfsiGGEYSGAAI-FVAEYSPDRKR--- 162
Cdd:cd17472 52 FGLLSDRIGRKP-----VILFGLLLFIAGSLLAAYATSIY---GLILGRALQG---SGAISSVVMaLLADLTREENRtka 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 163 -GFMGSWLDFGSIAGFVLGaatvALITHAvgearfaeWGWRIPFFLALPLGIIGL-YLRNRLEETPVYQQHSEQQAQKSK 240
Cdd:cd17472 121 mALIGASIGIAFAISMVLG----PLLAAH--------LGVSGLFLITAILSLVSLlILLFFVPDPPKIVQISEKEKKKLK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 241 pqkfsfkeIFVKHKRSLLVCIGLVIStNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYlSDKFGR 320
Cdd:cd17472 189 --------KLLKNKRLLRLDFSIFIL-HFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIY-AEKKGK 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447183265 321 RPFIFIGSFSLIFLSYpAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIaFNFS 392
Cdd:cd17472 259 MKQVFVSSILLIAVGF-LLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGI-YNTS 328
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
294-434 |
5.30e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.70 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 294 ALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSfsliFLSYPAFVLLNSGVNYQIFIGLLILaLSLNMSI-GVMASTL 372
Cdd:cd06179 35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGN----LLGVVGSIVAGTAKSVNMLIGGQAL-IGIGAGTqGLGAAVA 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447183265 373 PALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMIcGVVGIATAMYL 434
Cdd:cd06179 110 SELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYINA-IFNALALILLF 170
|
|
| Prefoldin_4 |
cd23165 |
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ... |
443-487 |
6.52e-05 |
|
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.
Pssm-ID: 467481 [Multi-domain] Cd Length: 103 Bit Score: 42.15 E-value: 6.52e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 447183265 443 IGGVPIAHNIEEAQELLEEFHETIEQKIENIDQKIQELQQKRQKL 487
Cdd:cd23165 52 IGEVFVHLSLEEAQERLEKAKEELEEEIEKLEEEIDEIEEEMKEL 96
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
77-360 |
9.02e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.55 E-value: 9.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 77 FIFRPLgglfFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetigLWapiLLLIVKIVQGFSiGGEYSGAAIFVAEY 156
Cdd:cd17388 52 FIFAPI----LGALSDRFGRRPVLLLSLAGAALDYLLMAFAPT-----LW---WLYLGRIIAGIT-GATGAVAAAYIADV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 157 SPDRKR----GFMGSWLDFGSIAGFVLGAAtvalithavgearFAEWGWRIPFFLALPLGIIGLYL------------RN 220
Cdd:cd17388 119 TPPEQRarnfGLLGAAFGLGFIAGPALGGL-------------LGEISPRAPFLVAAGLNGLNFLLglfvlpeslppeRR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 221 RLEETPVYQQHSEQQAQKSKPQKFSFKEIFVkhkrsLLVCIGLVISTNVTYYMLLTYlpSYFSHNLGYSeahgaLIIIAV 300
Cdd:cd17388 186 RAFRWRRANPFGSLRWLTGFPGLLGLLAVFF-----LIQLIGQVPATTWVLFTEDRF--DWSPTMVGLS-----LAVFGL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 301 MVGmLFVQPVIGYLSDKFGRRPFIFIGsFSLIFLSYPAFVLLNSGvnYQIFIGLLILALS 360
Cdd:cd17388 254 LHA-LFQAFVTGPIAKRLGEKRAILLG-LAADALGFLLLAFATQG--WMVFPILILLALG 309
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
74-189 |
9.04e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 44.90 E-value: 9.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 74 SVPFIFRPLGGLFFGHLGDKYGRQKVLaitVIIMSISTFGIGLIPSYETIGLWapillLIVKIVQGFSIGGEYSGAAIFV 153
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSL---LICMSVNGFFAFLSSFVQGYGLF-----LFCRLLSGFGIGGAVPTVFSYF 112
|
90 100 110
....*....|....*....|....*....|....*..
gi 447183265 154 AEYSPDRKRGFMGSWL-DFGSIAGFVLGAATVALITH 189
Cdd:cd17440 113 AEVLAREKRGEHLSWLcMFWMIGGIYASAMAWAIIPH 149
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
88-364 |
1.03e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 88 GHLGDKYGRQKVLAITVIIMSISTFgigLIPsyeTIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGS 167
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATL---LTP---LLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 168 WLdfgsIAGFVLGAATVALITHAVgearFAEWGWRIPFFLALPLGIIGLYlrnrleetpvyqqhseqqaqkskpqkfsfk 247
Cdd:cd17380 129 IV----TAGSYLGTLLGGLIGPLL----LEYYGWPSVFYFFGLLGLLWAL------------------------------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 248 eIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGySEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFI--- 324
Cdd:cd17380 171 -VWLIYLPPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTvts 248
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 447183265 325 ---FIGSFSLIFlsyPAFVLLNSGVNYQIFIGLLILALSLNMS 364
Cdd:cd17380 249 vrkLMQSIGFLG---PALFLLLLSHTDSFSLALLCMSVALGLS 288
|
|
| Prefoldin_2 |
pfam01920 |
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996. |
442-491 |
1.28e-04 |
|
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
Pssm-ID: 396482 [Multi-domain] Cd Length: 102 Bit Score: 41.05 E-value: 1.28e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 447183265 442 LIGGVPIAHNIEEAQELLEEFHETIEQKIENIDQKIQELQQKRQKLADKH 491
Cdd:pfam01920 47 LIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEKQLEKLEKELEELKEEL 96
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
252-409 |
1.37e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.65 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 252 KHKRSLLVCIGLVISTNVTYYMLLTYLPSYfSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPfIFIGSFSL 331
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSI-AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR-VLLIGLLL 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447183265 332 IFLSYPAFVLLNSGVnyQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVET 409
Cdd:COG0477 89 FGLASLLCGLAPSPE--LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
74-358 |
1.51e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.16 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 74 SVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLipsyetiGLWAPILLLIVKIVQGFSiGGEYSGAAIFV 153
Cdd:cd17341 41 AIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALAL-------AVSSYWGLLVLGFLLGFA-GANFASGQPWA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 154 AEYSPDRKRGfmgsWLDFGSIAGFVLGAATVALITHAVGEA---RFAEWGWRIPFFLALPL----GIIGLYLRNRLEETP 226
Cdd:cd17341 113 SFWFPKEKIG----GAAGGIAGAGNMGVAVSQLLAPLIAGAivfDGGFVGWRNAFFVPGILlaiaAVLVLLFGDDLPTGK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 227 VYQqhseqqAQKSKPQKFSFKeifvkHKR----SLL--VCIGLVISTNVtyymlltYLPSYFSHNLGYSEAHGAliIIAV 300
Cdd:cd17341 189 ASA------LEFLKVQLAVLK-----NYRtwilSLLygVTFGSFVGFSN-------VLPTYFKTRFGLPLVTAG--ILAA 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447183265 301 MVGML--FVQPVIGYLSDKFG-RRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILA 358
Cdd:cd17341 249 LFPLAgaLARPAGGWLSDRFGgRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVAL 309
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
69-219 |
1.57e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 44.06 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 69 ALATfSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIImsisTFGIGLIPSYETIGLWapilLLIVKIVQGFSIGGEYSG 148
Cdd:cd17372 37 ALIT-SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALW----TFYAGFLSAFAPNYMW----LIILRCLVGLGLGGGPQL 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447183265 149 AAIFvAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAVGearfaeWGWRIpFFLALPLGIIGLYLR 219
Cdd:cd17372 108 ASWY-LEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG------WRWLL-AFSSVPSSLLLVFYR 170
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
131-396 |
1.64e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 43.78 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 131 LLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGfVLGAATVALITHAVGearfaEWGWRIPFFLALP 210
Cdd:cd17361 107 LIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIG-ILIANLINYGTSKIK-----PNGWRLSLGLAAV 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 211 LGIIGLYLRNRLEETPVYQQhseqqaqkskpqkfsfkeifvkhkrsLLVCIGLVISTNVT-YYMLLTYLPSYFShNLGYS 289
Cdd:cd17361 181 PALILLLGSLFLPETPNSPQ--------------------------LVIAILIPFFQQLTgINVIMFYAPVLFQ-TLGFG 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 290 EA---HGALIIIAVMVGMLFVQPvigYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGV--------NYQIFIGLLILA 358
Cdd:cd17361 234 SDaslISAVITGAVNVVSTLVSI---YLVDRFGRRFLLLEGGVQMLASQVAIGILLAVKFgdggelpkAYAIAVVVLICL 310
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 447183265 359 LSLNM--SIGVMASTLPA-LFPTEIRYSALGIA----FNFSVVIA 396
Cdd:cd17361 311 YVAAFawSWGPLGWLVPSeIFPLETRSAGQSLTvavnFLFTFVIA 355
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
281-358 |
1.83e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.83e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 281 YFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIG-SFSLIFLSYPAFVllnsgVNYQIFIGLLILA 358
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGpLLTGLGLSLLGFA-----PNYWLLLLLVALA 94
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
82-189 |
2.10e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 43.76 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
90 100
....*....|....*....|....*....
gi 447183265 162 RGFMGSWLD-FGSIAGFVLGAATVALITH 189
Cdd:cd17438 121 RGEHLSWLCmFWMIGGLYASAMAWSIIPH 149
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
72-434 |
2.28e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 43.37 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 72 TFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwaPILLLIVKIVQGFSIGGEYSGAAI 151
Cdd:cd17353 43 AFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISL-------PLLFLGYGVLGGIGAGIGYITPVS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 152 FVAEYSPDrKRGFMGSWldfgSIAGFVLGAA-TVALITHAVG----EARFAEWGwriPFFLALpLGIIGLYLRNRLEETP 226
Cdd:cd17353 116 TAVKWFPD-KRGLATGI----VIAGFGLGSLiFSPLIAYLINtvgvPTTFLILG---IIFLII-IVIGAFLIRDPPKGWV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 227 VYQQHSEQQAQKSKPQKFSFKEIFvkhKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHN---LGYSEAHGALIIIAVMVG 303
Cdd:cd17353 187 PPGVDPLANNAENSPRDYTPREML---RTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEfagLDAGIAALAVSILSIFNG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 304 mlFVQPVIGYLSDKFGRRpFIFIGSFSLIFLSYpaFVLLNSGVNYQIFIGLLILALSlnmSIGVMASTLPALfpTEIRYS 383
Cdd:cd17353 264 --GGRPFWGWLSDKIGRK-NTLSIAFLIQGVAM--FLLPFIGSVAVLFVLGVALIGF---CYGGGFALFPAL--TADFFG 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 447183265 384 ALGIAFNFSVV-----IAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYL 434
Cdd:cd17353 334 TKNAGTNYGLLytakgVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
45-186 |
3.08e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 45 YGYVAYVLGKVFFPDAspsvqmiAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetig 124
Cdd:cd17370 219 FAFLILRAQELGLSAA-------LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS----- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 125 lwaPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRG--------------FMGSWL------DFGSIAGFVLGAATV 184
Cdd:cd17370 287 ---LWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGtayglfntvvgigwLLASLIagylwdLISPSAAFLFSAVLA 363
|
..
gi 447183265 185 AL 186
Cdd:cd17370 364 LI 365
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
82-434 |
3.11e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 42.73 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGD-KYGRQKVLAITVIIMSISTFGIGLIPSYetiglWAPILLlivKIVQGFSIGGEYSGAAIFVAEYSPDR 160
Cdd:cd17378 48 IGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY-----WVYAFL---RFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 161 KRGFMGSWLDFgsiaGFVLGAATVALIthavgeARFAEWGWRIPFFL-ALPLGIIGLYLRnrleetpvyqqhseqqaqks 239
Cdd:cd17378 120 WRGQVGMSTFF----FFVLGFMSLPGI------AYLNGSSWRVLYFWtSIPALIYCILVY-------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 240 kpqkfsfkeIFVKhKRSLLVCIGLVIStnVTYYML---LTYLPSyfshNLGYSEAHGALIIIAVMVgmlfvqpVIGYLSD 316
Cdd:cd17378 170 ---------LFAR-RLLAVMVIGFGIG--MVYYGIplaVGNLKF----NIYLSVALNALSELPAFV-------ITAFLLD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 317 KFGRRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIA 396
Cdd:cd17378 227 RFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGG 306
|
330 340 350
....*....|....*....|....*....|....*...
gi 447183265 397 GLTPTLTATLVEtthNLMVPAYYLMICGVVGIATAMYL 434
Cdd:cd17378 307 IFAPFIVSLGRK---NAALSFGVFGVAILLLGLFALGL 341
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
82-207 |
3.21e-04 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 42.79 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSF--------PIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 447183265 162 RGFMGSWLDFgsiaGFVLGAATVALITHAVGEARFAEWGWRIPFFL 207
Cdd:cd17446 120 RAVVGTLLGY----CYTLGQLILAGVAYAIRDWRWLQLAVSLPFFI 161
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
273-398 |
3.64e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 3.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 273 MLLTYLPSYFS--HNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFlsypAFVLLNSGVNYQI 350
Cdd:cd17330 14 IVFPVLPFYVRefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAV----SYVLLGLSRNLWL 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 447183265 351 FIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGI---AFNFSVVIAGL 398
Cdd:cd17330 90 LFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIisaAFGLGFILGPA 140
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
57-429 |
4.94e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 42.40 E-value: 4.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 57 FPDASPSVQMIAALATfSVPFIFRPLGGLFFghlgDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglwAPILLLIVKI 136
Cdd:cd17314 33 FGYSSSQIATAASLSN-LGMLLTQPILGFIA----DSFGPRPLMALAGIMVLAGYTYLSYVFN-------SFPLSYACFV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 137 VQGFSIGGEYSGAAIFVAEYSPDRkRGFMGSWLDFGSIAGFVLGAATVALITHavgearFAEWGWRIPFFLALPLGIIGL 216
Cdd:cd17314 101 FIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWV------FYGLALVYTILGILAAIVLSV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 217 YLRNRLEETPVYQQHSEQQAQKSKPQKFSFKEifvkhKRSLLVCIgLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALI 296
Cdd:cd17314 174 VSLLGFKEPPDNQARLHVQKKKTQTMGEIFRD-----KVFWILFI-AIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 297 IIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALF 376
Cdd:cd17314 248 MSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVF 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 447183265 377 PTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIA 429
Cdd:cd17314 328 GTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASA 380
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
82-442 |
5.60e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 42.39 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglwapiLLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGS----WLDFGSIAGFVLGAATVALITHAvgearfaewGWRIPFFL-ALPLGIIGLYLRnRLEETPVYQQHSeqqa 236
Cdd:cd17437 119 RGFLTSfpeiFINIGILLGYVSNYAFSGLPLHV---------GWRLMLGVgAVPSLFLAIGVL-AMPESPRWTPAV---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 237 qkskpqkfsfkeifvkhKRSLLVCIGLVISTNVT-YYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLS 315
Cdd:cd17437 185 -----------------RRMLIAALGIHFFQQASgIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 316 DKFGRRPFIFIGS----FSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNM---SIG------VMAStlpALFPTEIRY 382
Cdd:cd17437 248 DKVGRRPLLLTSTggmtLSLTALATSLTFIDRNGGGLTWALVLAITAVCSFVaffSIGagpitwVYSS---EIFPLRLRA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447183265 383 --SALGIAFNfsvviAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMY---LKETANKPL 442
Cdd:cd17437 325 qgASLGVVVN-----RLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAAWVFFyffLPETKGKSL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-216 |
6.46e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.15 E-value: 6.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 42 FGVYGYVAYVLGKVFFpdaSPSVQMIAALATFSVPFIfrpLGGLFFGHLGDKYGRQKVLAITVIIMsISTFGIGLIPSYe 121
Cdd:cd17324 215 FALYTYLAPFLTDVPG---FSSSAIIGLLLLFGVAGV---VGSPLAGRLADRGGRRALLIALLLLA-AALLLLTLLGPS- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 122 tiglwaPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGswldfGSIAGFVLGAATVALITHAVgearFAEWGW 201
Cdd:cd17324 287 ------PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASS-----LYLAAYNLGGALGAALGGLV----LDHGGW 351
|
170
....*....|....*
gi 447183265 202 RIPFFLALPLGIIGL 216
Cdd:cd17324 352 AGVGWVGAALLLLAL 366
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
293-467 |
7.52e-04 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 41.95 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 293 GALIIIAVM-VGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLsypaFVLLNSGVNYQIFIGLLILALSLNMSIGvmAST 371
Cdd:cd17396 36 GVAYVISGIgIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALF----FVGILFSPNLIIAYVFALLAGAANSFLD--TGT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 372 LPALfpTEIRYSALGIA---FNFSVVIAG-LTPTLTATLVEtthNLMVPAYYLMICGVVGIATAMYLKeTANKPLIGGVP 447
Cdd:cd17396 110 YPAL--MEAFPKASGSAnilVKAFVSFGQfLLPFIIAFLAA---NNLWYGWSFIVPAAVLVLNALLLL-KLSFPPQTVTA 183
|
170 180
....*....|....*....|
gi 447183265 448 IAHNIEEAQELLEEFHETIE 467
Cdd:cd17396 184 ANTKQKEIPVKREKPKFLIE 203
|
|
| SPEC |
smart00150 |
Spectrin repeats; |
447-493 |
8.56e-04 |
|
Spectrin repeats;
Pssm-ID: 197544 [Multi-domain] Cd Length: 101 Bit Score: 38.85 E-value: 8.56e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 447183265 447 PIAHNIEEAQELLEEfHETIEQKIENIDQKIQELQQKRQKLADKHPD 493
Cdd:smart00150 25 DLGKDLESVEALLKK-HEAFEAELEAHEERVEALNELGEQLIEEGHP 70
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
62-365 |
8.85e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.54 E-value: 8.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 62 PSVQMIAALATFSVPFIF------RPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVK 135
Cdd:cd17333 20 PSLEEAFNLNVADVSVIFssqnagYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSI--------YLFVVLM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 136 IVQGFSIGGEYSGAAIFVAEYSPdRKRGFMGSWLDFGSIAGfvlGAATVALITHAVGEARFAEWGWRIPFFLALPLGIig 215
Cdd:cd17333 92 FLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLG---ALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAI-- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 216 LYLRNRLEETPvyqQHSEQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYmllTYLPSYFSHNLGYSEAHGAL 295
Cdd:cd17333 166 LILLTLFPELP---SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFS---SWVPSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 296 IIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIflsypAFVLLNSGVNYQIFIGLLILALSLNMSI 365
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGAL-----LGLLILLLAPTLVVGLVATALLGLFMAA 304
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
88-387 |
1.23e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 88 GHLGDKYGRQKVLAITVIIMSI-STFGIGLIPSyetiglwaPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPD---RKRG 163
Cdd:cd17490 52 GILSDRIGKRKLFIIIGLLFTVlASLIMILFPS--------PWGLLIARFLSGIAAATWVSFTVLYASYFPPDeaaKAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 164 FMGSWLDFGSIAGFVLGAatvalithavgeaRFAE-WGWRIPFFLALPLGIIGLYLRNRLEETPVyqqhseqqaqKSKPQ 242
Cdd:cd17490 124 LINLVNNLGQLIAFLIGG-------------LIAEhFGMRAPFLLAALAGVLGFILSLFIKEERR----------EKKPV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 243 KFSFKEIFVKHKRSLLVCIGL--VISTNVTYYMLLTYLPSYfSHNLGYSEAH-GALIIIAVMVGMLFVQPVIGYLSDKFG 319
Cdd:cd17490 181 LTELKELLSVLKDKKLLFFSLlaILQQMITFSTTFGFTPLI-AKQLGASSFQlGLLSIIYLLPNALASLLSGTLFYKKLG 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447183265 320 RRPFIFIGSFSLIFLSYPAFVLLNSGVNY--QIFIGL-LILALSLNMSIGVMAstlpalFPTEIRYSALGI 387
Cdd:cd17490 260 ERNTIIIGFLLLGAYCFLIPFAPNLTLLYllQALNGFgTGILFPLLMSLSIEG------VPAEQRSTAMGF 324
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
249-321 |
1.67e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.56 E-value: 1.67e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447183265 249 IFVKHKRSLLVCIGLVISTnVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRR 321
Cdd:cd17337 203 ILFRNPKIAIGGIVRIINT-LSQFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWR 274
|
|
| Prefoldin |
cd00890 |
prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and ... |
443-481 |
1.68e-03 |
|
prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits; the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes, there are two or more paralogous genes encoding each subunit, adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.
Pssm-ID: 467470 Cd Length: 79 Bit Score: 37.32 E-value: 1.68e-03
10 20 30
....*....|....*....|....*....|....*....
gi 447183265 443 IGGVPIAHNIEEAQELLEEFHETIEQKIENIDQKIQELQ 481
Cdd:cd00890 40 VGGVFIEKSKEETKEELEEKLDELQKEIKKLEQQLEAKT 78
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
66-218 |
1.93e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.67 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 66 MIAALAtFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwaPILLLIVKIVQGFSIGGE 145
Cdd:cd17353 249 GIAALA-VSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSV-------AVLFVLGVALIGFCYGGG 320
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447183265 146 YSGAAIFVAEYSPDRkrgfmgswlDFGSIAGFVLGA-ATVALITHAVGEARFAEWGWRIPFFLALPLGIIGLYL 218
Cdd:cd17353 321 FALFPALTADFFGTK---------NAGTNYGLLYTAkGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
73-360 |
2.06e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.25 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSiGGEYSGAAIF 152
Cdd:cd17330 40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL--------WLLFLARFLDGLT-GGNVSVAQAY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 153 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAVGEArfaewgwrIPFFLALPLGIIGLYLrnrleetpvyqqhs 232
Cdd:cd17330 111 IADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYA--------LPFLVAAALALLNLVL-------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 233 eqqaqkskpqkfsfkeIFVKHKRSLLVCIGLVIStNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQ-PVI 311
Cdd:cd17330 169 ----------------VLFFLPPLRRLLLVYFLI-ALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLI 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 447183265 312 GYLSDKFGRRPFIFIGSFSLIflsyPAFVLLNSGVNYQIF-IGLLILALS 360
Cdd:cd17330 232 PRLAKRLGERKLLRLGLLLAI----IGLLLLPFASSVPLLvLAAAILAFG 277
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
452-490 |
2.28e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 39.52 E-value: 2.28e-03
10 20 30
....*....|....*....|....*....|....*....
gi 447183265 452 IEEAQELLEEFHETIEQKIENIDQKIQELQQKRQKLADK 490
Cdd:COG1579 133 LAELEAELEEKKAELDEELAELEAELEELEAEREELAAK 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
47-192 |
2.29e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 47 YVAYVLGkvffpdaSPSVQMIAALATFSVPFIfrpLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglW 126
Cdd:COG2211 254 YFKYVLG-------LSAALVGLLLALYFLAAL---LGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP------G 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447183265 127 APILLLIVKIVQGFSIGGEYSGAAIFVAEYSPD-------RKRGFMGSWLDFGSIAGFVLGAATVALITHAVG 192
Cdd:COG2211 318 NLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
257-399 |
2.65e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.84 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 257 LLVCIGLVISTNVTYYMLLtyLPSyFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRP------FIFIGSFS 330
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGL--LPD-IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRlllvllLLFILGNL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447183265 331 LIFLSYPAFVLLnsgvnyqifIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIafnfsvVIAGLT 399
Cdd:cd17324 80 LAALAPSFALLL---------LARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGL------VFSGLT 133
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
82-392 |
2.75e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 40.17 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQkvlaiTVIIMSISTFGIGLIPSYETIGLWApilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17435 51 LASLTGGVLIDRYGRR-----TAIILTSCLLVLGSLLLVCSVSYTV---LIVGRIAIGVSISLSSIATCVYIAEIAPQHR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 162 RGFMGSWLDFGSIAGFVLGAAT---VALITHavgearfaewGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHSEQQAQK 238
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYISnyaFANVSN----------GWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNMRAR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 239 skpqkfsfkeifvkhkrsLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYsEAHGALIIIAVMVGMLFVQPVIG--YLSD 316
Cdd:cd17435 193 ------------------LLIGLTLVFFVQITGQPNILFYASTVLKSVGF-QSNEAASLASTGVGVVKVVSTIPaiFLVD 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447183265 317 KFGRRPFIFIGSfsliflSYPAFVLLNSGVnYQIFIGLLILALSLNMSIGVMAS-TLPALFPTEIRYSALGIAFNFS 392
Cdd:cd17435 254 KVGSKTFLCIGS------SVMAVSLVTMGL-WLSLASLLVYVAAFSIGLGPMPWlVLSEIFPGGIRGRAMALTSSMN 323
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
82-186 |
3.51e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.49 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetiglwAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17365 221 IGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPA-------SLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEV 293
|
90 100
....*....|....*....|....*....
gi 447183265 162 R----GFMGSWLDFGSIAGFVLGAATVAL 186
Cdd:cd17365 294 RatgvGWALGVGRLGAILGPLLGGLLLAA 322
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
252-435 |
3.53e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.84 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 252 KHKRSLLVCIGLVISTNVTYYMLLTYLPsYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGsFSL 331
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG-LLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 332 IFLSYPAFVLLNSgvnYQIF-IGLLILALSLNMSIGVMASTLPALFPTE--IRYSALGIAFNFSVVIAGLtptLTATLVE 408
Cdd:COG0738 83 MALGLLLFALAPS---YPLLlLALFLLGLGLGLLDVAANPYVAALGPETaaSRLNLLHAFFSLGALLGPL---LGGLLIL 156
|
170 180
....*....|....*....|....*..
gi 447183265 409 TTHNLMVPAYYLMICGVVGIATAMYLK 435
Cdd:COG0738 157 LGLSLSWHLPYLILAVLLLLLALLFLR 183
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
274-363 |
3.73e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 274 LLTYLPSYFsHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFvllnsGVNYQIFIG 353
Cdd:cd17335 16 LLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL-----FFVAQIFWL 89
|
90
....*....|
gi 447183265 354 LLILALSLNM 363
Cdd:cd17335 90 LLLLVILGAF 99
|
|
| YlbF |
COG3679 |
Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm ... |
453-495 |
4.02e-03 |
|
Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development) [Signal transduction mechanisms];
Pssm-ID: 442895 [Multi-domain] Cd Length: 112 Bit Score: 37.12 E-value: 4.02e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 447183265 453 EEAQELLEEFH---ETIEQKI---ENIDQKIQELQQKRQKLADKHPDIA 495
Cdd:COG3679 34 EEAQKLIREFQklqEELQEKQrfgQEHTEEEMKKLQELKRELDLNPVIA 82
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
265-432 |
4.04e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.51 E-value: 4.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 265 ISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDK-----FGRRPFIFIGSFSLIFLSYPAF 339
Cdd:cd17332 9 FGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRtrsrwGRFRPWLLWGAIPLALLFVLLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 340 VLLNSGVNyqifiGLLILALSLNMSIGVMAS--TLP--ALFPT-----EIRYSALGIAFNFSVVIAGLTPTLTATLVETT 410
Cdd:cd17332 89 TTPDGSGT-----GKLIYALITYILLDLLYTlvNIPytALIPEltddpEERTSLTSWRMFFATIGGLLVTVLPPPLVAYF 163
|
170 180
....*....|....*....|..
gi 447183265 411 HNLMVPAYYLMICGVVGIATAM 432
Cdd:cd17332 164 GGGNASRGYFLTALIIGIIGII 185
|
|
| GPH_sucrose |
TIGR01301 |
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ... |
286-338 |
4.49e-03 |
|
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.
Pssm-ID: 273545 [Multi-domain] Cd Length: 477 Bit Score: 39.40 E-value: 4.49e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447183265 286 LGYSEAHGALIIIAVMVGMLFVQPVIGYLSD----KFG-RRPFIFIGS----FSLIFLSYPA 338
Cdd:TIGR01301 34 LGIPHAWASIIWLCGPLSGLLVQPLVGYLSDrctsRFGrRRPFIAAGAalvaFAVILIGFAA 95
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
285-441 |
5.26e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.16 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 285 NLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRpfiFIGSFSLIFLSYPAFVLLNSGVNYQifiGLLILALSLNMS 364
Cdd:cd17341 28 DLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGR---RVFIASLLLLLIPLLALALAVSSYW---GLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 365 IGVMASTLP---ALFPTEIRYSALGIAF---NFSVVIAGLT-PTLTATLVETTHNL---MVPAYYLMICGVVGIATAMYL 434
Cdd:cd17341 102 GANFASGQPwasFWFPKEKIGGAAGGIAgagNMGVAVSQLLaPLIAGAIVFDGGFVgwrNAFFVPGILLAIAAVLVLLFG 181
|
....*..
gi 447183265 435 KETANKP 441
Cdd:cd17341 182 DDLPTGK 188
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
73-207 |
5.85e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.13 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 73 FSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSyetigLWApilLLIVKIVQGFsIGGEYSGAAIF 152
Cdd:PRK09874 60 FSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQN-----IWQ---FLILRALLGL-LGGFVPNANAL 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 447183265 153 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHavgearfaEWGWRIPFFL 207
Cdd:PRK09874 131 IATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAD--------SYGLRPVFFI 177
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
82-189 |
6.15e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 39.01 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 82 LGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETiglwapilLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRK 161
Cdd:cd17363 49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGF--------FLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
|
90 100
....*....|....*....|....*....
gi 447183265 162 RGFMGSWLD-FGSIAGFVLGAATVALITH 189
Cdd:cd17363 121 RGEHLSWLCmFWMIGGLYASAMAWAIIPH 149
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
62-213 |
7.20e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 38.64 E-value: 7.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 62 PSVQMiaALATfSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYEtiglWapilLLIVKIVQGFS 141
Cdd:cd17441 32 PSWQV--ALLT-SVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYS----W----ILVLRGLVGFG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447183265 142 IGGEYSGAAIFvAEYSPDRKRGFMGSWLDfgsiAGFVLGAATVALITHAVGEArfaeWGWRIPFFL-ALPLGI 213
Cdd:cd17441 101 IGGVPQSVTLY-AEFLPMKSRAKCILLIE----VFWALGTVFEVLLAVFVMPT----LGWRWLLILsALPLLI 164
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
85-227 |
9.64e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 38.40 E-value: 9.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447183265 85 LFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYetiglwapILLLIVKIVQGFSIGGEYSGA-AIFVAEYSPDRKRG 163
Cdd:cd17476 51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNF--------IFFIICRALQGLGPAFLLPNAmALLGRTYPPGPRKN 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447183265 164 FMGSWLDFGSIAGFVLGAATVALIthavgeARFAEWGWrIPFFLALPLGIIGL--YLRNRLEETPV 227
Cdd:cd17476 123 IVFSLFGATAPLGFALGGVFGGLF------AQLAWWPW-IFWFLAILAAIVAVaaIFWTSPSFIAV 181
|
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| |
