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Conserved domains on  [gi|447202192|ref|WP_001279448|]
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MULTISPECIES: isochorismate family cysteine hydrolase YcaC [Bacillus]

Protein Classification

hydrolase( domain architecture ID 10099061)

putative YcaC-like hydrolase with unknown specificity

CATH:  3.40.50.850
Gene Ontology:  GO:0016787
PubMed:  9782055
SCOP:  4000591

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C_hydro_YcaC NF041461
isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of ...
 5-205 3.24e-153

isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of unknown function, found in both Pseudomonas aeruginosa and Escherichia coli K-12, with an isochorismate family crystal structure.


:

Pssm-ID: 469349  Cd Length: 201  Bit Score: 422.50  E-value: 3.24e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   5 YSRLSKSDAAVLLVDHQTGLISsLVRDYGVDEFKNNVLALANTANFFDLPVILTTSFEDGPNGPLMQELIELFPNAPKIA 84
Cdd:NF041461   2 YKRLDKDDAAVLLVDHQTGLLS-LVRDFSPDEFKNNVLALADIAKYFNLPTILTTSFEDGPNGPLVPELKEMFPDAPYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  85 RPGQINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAHGGVQLM 164
Cdd:NF041461  81 RPGQINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSALEEGYEVFVVTDASGTFNEVTRDAAWDRMSQAGAQLM 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 447202192 165 NWFSVAAELQRDWRNDIEGFGNLLAKHLPSYQNIIGSYKAA 205
Cdd:NF041461 161 NWFAVACELHRDWRNDVEGLGTLFSNHIPDYRNLMTSYAAV 201
 
Name Accession Description Interval E-value
C_hydro_YcaC NF041461
isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of ...
 5-205 3.24e-153

isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of unknown function, found in both Pseudomonas aeruginosa and Escherichia coli K-12, with an isochorismate family crystal structure.


Pssm-ID: 469349  Cd Length: 201  Bit Score: 422.50  E-value: 3.24e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   5 YSRLSKSDAAVLLVDHQTGLISsLVRDYGVDEFKNNVLALANTANFFDLPVILTTSFEDGPNGPLMQELIELFPNAPKIA 84
Cdd:NF041461   2 YKRLDKDDAAVLLVDHQTGLLS-LVRDFSPDEFKNNVLALADIAKYFNLPTILTTSFEDGPNGPLVPELKEMFPDAPYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  85 RPGQINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAHGGVQLM 164
Cdd:NF041461  81 RPGQINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSALEEGYEVFVVTDASGTFNEVTRDAAWDRMSQAGAQLM 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 447202192 165 NWFSVAAELQRDWRNDIEGFGNLLAKHLPSYQNIIGSYKAA 205
Cdd:NF041461 161 NWFAVACELHRDWRNDVEGLGTLFSNHIPDYRNLMTSYAAV 201
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 14-175 3.45e-64

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 195.51  E-value: 3.45e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  14 AVLLVDHQTGLISSLVRdygVDEFKNNVLALANTANFFDLPVILTTSFEdGPNGPLMQELIELFPNAPKIARPGqINAWD 93
Cdd:cd01012    1 ALLLVDVQEKLAPAIKS---FDELINNTVKLAKAAKLLDVPVILTEQYP-KGLGPTVPELREVFPDAPVIEKTS-FSCWE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  94 NEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAHGGVQLMNWFSVAAEL 173
Cdd:cd01012   76 DEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQAGAVLTTSESVLFEL 155


                 ..
gi 447202192 174 QR 175
Cdd:cd01012  156 QR 157
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 14-164 3.24e-30

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 109.22  E-value: 3.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  14 AVLLVDHQTGLIS-SLVRDYGVDEFKNNVLALANTANFFDLPVILTT--------SF-----------EDGPNGPLMQEL 73
Cdd:COG1335    1 ALLVIDVQNDFVPpGALAVPGADAVVANIARLLAAARAAGVPVIHTRdwhppdgsEFaefdlwpphcvPGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  74 iELFPNAPKIARPGqINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAAL 153
Cdd:COG1335   81 -APLPGDPVVDKTR-YSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEAAL 158

                        170
                 ....*....|.
gi 447202192 154 MRMAHGGVQLM 164
Cdd:COG1335  159 ARLRAAGATVV 169
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 13-166 5.70e-23

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 90.93  E-value: 5.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   13 AAVLLVDHQTGLISSLVRD-YGVDEFKNNVLALANTANFFDLPVILTT------------------SFEDGPNGP-LMQE 72
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKvEGIAAILENINRLLKAARKAGIPVIFTRqvpepddadfalkdrpspAFPPGTTGAeLVPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   73 LiELFPNAPKIARPGqINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAA 152
Cdd:pfam00857  81 L-APLPGDLVVDKTR-FSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAA 158

                         170
                  ....*....|....
gi 447202192  153 LMRMAHGGVQLMNW 166
Cdd:pfam00857 159 LERLAQRGAEVTTT 172
PLN02621 PLN02621
nicotinamidase
 6-173 2.28e-11

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 60.56  E-value: 2.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   6 SRLSKSDAAVLLVDHQTGLISSLVRdygvdEFKNNVLALANTANFFDLPVILTTSFEDGPN--GPLMQ----ELI----- 74
Cdd:PLN02621  13 KRDPDPKQAALLVIDMQNYFSSMAE-----PILPALLTTIDLCRRASIPVFFTRHSHKSPSdyGMLGEwwdgDLIldgtt 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  75 --ELFPNAPKIARPGQI------NAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSK 146
Cdd:PLN02621  88 eaELMPEIGRVTGPDEVvekstySAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANE 167

                        170       180
                 ....*....|....*....|....*..
gi 447202192 147 QVADAALMRMAHGGVQLMNWFSVAAEL 173
Cdd:PLN02621 168 ELHEATLKNLAYGFAYLVDCDRLEAGL 194
 
Name Accession Description Interval E-value
C_hydro_YcaC NF041461
isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of ...
 5-205 3.24e-153

isochorismate family cysteine hydrolase YcaC; YcaC is a well-conserved cysteine hydrolase of unknown function, found in both Pseudomonas aeruginosa and Escherichia coli K-12, with an isochorismate family crystal structure.


Pssm-ID: 469349  Cd Length: 201  Bit Score: 422.50  E-value: 3.24e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   5 YSRLSKSDAAVLLVDHQTGLISsLVRDYGVDEFKNNVLALANTANFFDLPVILTTSFEDGPNGPLMQELIELFPNAPKIA 84
Cdd:NF041461   2 YKRLDKDDAAVLLVDHQTGLLS-LVRDFSPDEFKNNVLALADIAKYFNLPTILTTSFEDGPNGPLVPELKEMFPDAPYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  85 RPGQINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAHGGVQLM 164
Cdd:NF041461  81 RPGQINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSALEEGYEVFVVTDASGTFNEVTRDAAWDRMSQAGAQLM 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 447202192 165 NWFSVAAELQRDWRNDIEGFGNLLAKHLPSYQNIIGSYKAA 205
Cdd:NF041461 161 NWFAVACELHRDWRNDVEGLGTLFSNHIPDYRNLMTSYAAV 201
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 14-175 3.45e-64

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 195.51  E-value: 3.45e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  14 AVLLVDHQTGLISSLVRdygVDEFKNNVLALANTANFFDLPVILTTSFEdGPNGPLMQELIELFPNAPKIARPGqINAWD 93
Cdd:cd01012    1 ALLLVDVQEKLAPAIKS---FDELINNTVKLAKAAKLLDVPVILTEQYP-KGLGPTVPELREVFPDAPVIEKTS-FSCWE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  94 NEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAHGGVQLMNWFSVAAEL 173
Cdd:cd01012   76 DEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQAGAVLTTSESVLFEL 155


                 ..
gi 447202192 174 QR 175
Cdd:cd01012  156 QR 157
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 14-164 3.24e-30

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 109.22  E-value: 3.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  14 AVLLVDHQTGLIS-SLVRDYGVDEFKNNVLALANTANFFDLPVILTT--------SF-----------EDGPNGPLMQEL 73
Cdd:COG1335    1 ALLVIDVQNDFVPpGALAVPGADAVVANIARLLAAARAAGVPVIHTRdwhppdgsEFaefdlwpphcvPGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  74 iELFPNAPKIARPGqINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAAL 153
Cdd:COG1335   81 -APLPGDPVVDKTR-YSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEAAL 158

                        170
                 ....*....|.
gi 447202192 154 MRMAHGGVQLM 164
Cdd:COG1335  159 ARLRAAGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 14-157 3.88e-29

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 106.20  E-value: 3.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  14 AVLLVDHQTGLIS-SLVRDYGVDEFKNNVLALANTANFFDLPVILTTSF------------------EDGPNGPLMQELi 74
Cdd:cd00431    1 ALLVVDMQNDFVPgGGLLLPGADELVPNINRLLAAARAAGIPVIFTRDWhppddpefaellwpphcvKGTEGAELVPEL- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  75 ELFPNAPKIARpGQINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALM 154
Cdd:cd00431   80 APLPDDLVIEK-TRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEEDHEAALE 158


                 ...
gi 447202192 155 RMA 157
Cdd:cd00431  159 RLA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 13-166 5.70e-23

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 90.93  E-value: 5.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   13 AAVLLVDHQTGLISSLVRD-YGVDEFKNNVLALANTANFFDLPVILTT------------------SFEDGPNGP-LMQE 72
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKvEGIAAILENINRLLKAARKAGIPVIFTRqvpepddadfalkdrpspAFPPGTTGAeLVPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   73 LiELFPNAPKIARPGqINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAA 152
Cdd:pfam00857  81 L-APLPGDLVVDKTR-FSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAA 158

                         170
                  ....*....|....
gi 447202192  153 LMRMAHGGVQLMNW 166
Cdd:pfam00857 159 LERLAQRGAEVTTT 172
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 109-164 7.11e-12

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 61.90  E-value: 7.11e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 447202192 109 LIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAHGGVQLM 164
Cdd:cd01011  141 VDVVGLATDYCVKATALDALKAGFEVRVLEDACRAVDPETIERAIEEMKEAGVVLV 196
PLN02621 PLN02621
nicotinamidase
 6-173 2.28e-11

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 60.56  E-value: 2.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192   6 SRLSKSDAAVLLVDHQTGLISSLVRdygvdEFKNNVLALANTANFFDLPVILTTSFEDGPN--GPLMQ----ELI----- 74
Cdd:PLN02621  13 KRDPDPKQAALLVIDMQNYFSSMAE-----PILPALLTTIDLCRRASIPVFFTRHSHKSPSdyGMLGEwwdgDLIldgtt 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  75 --ELFPNAPKIARPGQI------NAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSK 146
Cdd:PLN02621  88 eaELMPEIGRVTGPDEVvekstySAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANE 167

                        170       180
                 ....*....|....*....|....*..
gi 447202192 147 QVADAALMRMAHGGVQLMNWFSVAAEL 173
Cdd:PLN02621 168 ELHEATLKNLAYGFAYLVDCDRLEAGL 194
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 96-165 6.35e-11

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 59.31  E-value: 6.35e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  96 EFVKAIEATgkkKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAHGGVQLMN 165
Cdd:PTZ00331 139 QILKAHGVR---RVFICGLAFDFCVLFTALDAVKLGFKVVVLEDATRAVDPDAISKQRAELLEAGVILLT 205
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 14-153 9.72e-11

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 57.99  E-value: 9.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447202192  14 AVLLVDHQTGLISSLVRDYGVDEFKNNVLALANTANFFDLPVIL-------TTSFEDGPNGPLMQELIELFPNAPKIaRP 86
Cdd:cd01014    1 ALLVIDVQNGYFDGGLPPLNNEAALENIAALIAAARAAGIPVIHvrhiddeGGSFAPGSEGWEIHPELAPLEGETVI-EK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447202192  87 GQINAWDNEEFVKAIEATGKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAAL 153
Cdd:cd01014   80 TVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLPDHGGVL 146
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
109-164 3.94e-06

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 45.75  E-value: 3.94e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 447202192 109 LIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADA--ALMRMAHGGVQLM 164
Cdd:PRK11609 145 LIVMGLATDYCVKFTVLDALALGYQVNVITDGCRGVNLQPQDSahAFMEMSAAGATLY 202
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
105-158 1.49e-05

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 44.07  E-value: 1.49e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 447202192 105 GKKKLIIAGVVTDVCVAFPALSAVKAGYEVFVVTDASGTFSKQVADAALMRMAH 158
Cdd:COG1535  131 GRDQLIITGVYAHIGCLATAVDAFMRDIQPFVVADAVADFSREEHRMALEYVAG 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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