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Conserved domains on  [gi|447207698|ref|WP_001284954|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Pseudomonadota]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-97 1.03e-18

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 77.62  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447207698  15 IAAIGAAMSDISRVKILSALMDGrAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESM 94
Cdd:COG0640   10 LAELFKALADPTRLRILRLLAEG-ELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88


                 ...
gi 447207698  95 MGI 97
Cdd:COG0640   89 LEL 91
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-97 1.03e-18

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 77.62  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447207698  15 IAAIGAAMSDISRVKILSALMDGrAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESM 94
Cdd:COG0640   10 LAELFKALADPTRLRILRLLAEG-ELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88


                 ...
gi 447207698  95 MGI 97
Cdd:COG0640   89 LEL 91
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 19-95 3.34e-16

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 3.34e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447207698  19 GAAMSDISRVKILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLA-GKDIAELMESMM 95
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTdAERLLALLESLL 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-95 7.93e-14

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.15  E-value: 7.93e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447207698    29 KILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESMM 95
Cdd:smart00418   1 KILKLLAEGEL-CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 15-91 3.08e-13

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 62.86  E-value: 3.08e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447207698  15 IAAIGAAMSDISRVKILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELM 91
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGEL-CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 21-76 5.47e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 48.30  E-value: 5.47e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 447207698   21 AMSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGK 76
Cdd:pfam12840   6 ALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
15-97 1.03e-18

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 77.62  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447207698  15 IAAIGAAMSDISRVKILSALMDGrAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESM 94
Cdd:COG0640   10 LAELFKALADPTRLRILRLLAEG-ELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88


                 ...
gi 447207698  95 MGI 97
Cdd:COG0640   89 LEL 91
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 19-95 3.34e-16

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 3.34e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447207698  19 GAAMSDISRVKILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLA-GKDIAELMESMM 95
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTdAERLLALLESLL 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-95 7.93e-14

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.15  E-value: 7.93e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447207698    29 KILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESMM 95
Cdd:smart00418   1 KILKLLAEGEL-CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 15-91 3.08e-13

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 62.86  E-value: 3.08e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447207698  15 IAAIGAAMSDISRVKILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELM 91
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGEL-CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 21-76 5.47e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 48.30  E-value: 5.47e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 447207698   21 AMSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGK 76
Cdd:pfam12840   6 ALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 27-69 6.95e-06

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 42.05  E-value: 6.95e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 447207698   27 RVKILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLI 69
Cdd:pfam01022   4 RLKILKLLAEGEL-CVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
1-95 3.16e-05

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 42.26  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447207698   1 MANLIRKEVTFESSIAAIGAAMSDISR--VKILSALMDGRAW-TATELSSVANISASTASSHLSKLLDCQLIT---VVAQ 74
Cdd:COG3355    1 MSDSIEMLVRLEPDLEDVLECVYGLSEtdAEVYLILLENGEPlTVEELAEALDRSRSTVYRSLQKLLEAGLVErekRNLE 80

                         90       100
                 ....*....|....*....|.
gi 447207698  75 GKHRYFRLAGKDIAELMESMM 95
Cdd:COG3355   81 GGGYPYVYYAIDPEELKEKLV 101
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
15-87 5.84e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 41.17  E-value: 5.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447207698  15 IAAIGAAMSDISRVKILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITVV----AQGKHR-YFRLAGKDI 87
Cdd:COG1777    7 LDRLLDALGNPTRRRILALLSEEPA-YVSELARELGVSRQAVYKHLRKLEEAGLVESYregrEDGRARkYYRLSAFRL 83
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
16-83 8.79e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 41.40  E-value: 8.79e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447207698  16 AAIGAAMSDISRvKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLA 83
Cdd:COG3398   89 KILAYLRRETPR-RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLN 155
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
27-97 4.29e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 40.26  E-value: 4.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447207698  27 RVKILSALMDGRAwTATELSSVANISASTASSHLSKLLDCQLITvvaQGKHRYfRL--AGKDIAELMESMMGI 97
Cdd:COG4742   18 RKNILLLLAEGPK-TRSELAESLDVSRSTILRQLKELEERGLIE---RDDGEY-ELttLGRLVVEEMEPLLDT 85
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
20-90 5.73e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.82  E-value: 5.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447207698  20 AAMSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHR-----YFRLAGKDIAEL 90
Cdd:COG2345    8 AALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRgrpakLYRLTEAGRARF 83
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
29-69 6.80e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 33.56  E-value: 6.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 447207698   29 KILSALM-DGRAwTATELSSVANISASTASSHLSKLLDCQLI 69
Cdd:pfam13412   5 KILNLLQeNPRI-SQRELAERLGLSPSTVNRRLKRLEEEGVI 45
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 28-79 8.12e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 34.03  E-value: 8.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 447207698   28 VKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRY 79
Cdd:pfam01978  11 AKVYLALLKLGPATADEIAEESGVPRSKVYEVLRSLEDKGLVEREKGRPKKY 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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