|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-415 |
1.95e-87 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 270.21 E-value: 1.95e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 14 RARLIPFMLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGF 93
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 94 LSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHgfmghp 173
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 174 GWFWMFVIEGLLAVGAGVFTFFWLddtpgqarflskqektllinqlaseeqqkvtsrlsdalrnGRVWQLAIIYLTIQVA 253
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL----------------------------------------RQVWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 254 VYGLIFFLPTQVAALLGTKVgFTASVVTAIPWVAALFGTWLIPRYSDK--TGERRNVAALTLLAAGIGIGLSGLL-SPVL 330
Cdd:cd17319 195 LYGLLTWLPTYLKQARGFSL-KQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTtSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 331 AIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSL 410
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
....*
gi 481041873 411 IIFTL 415
Cdd:cd17319 354 LVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
24-415 |
1.26e-62 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 207.19 E-value: 1.26e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 24 LYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADT 103
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 104 EAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHgfmghpGWFWMFVIEG 183
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHF------SWQWAFIIEG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 184 LLAVGAGVFTFFWLDDTPGQARFLSKQEKTLLINQLASEEQQKV-----TSRLSDALRNGRVWQLAIIYLTIQVAVYGLI 258
Cdd:TIGR00893 156 VLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGpstpkKYQIKELLKDRRVWGLALGQFLVNIGLGFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 259 FFLPTQVAALLGTKVgFTASVVTAIPWVAALFGTWLIPRYSDKTGER-------RNVAALTLLAAGIGIGLSGLLSPVLA 331
Cdd:TIGR00893 236 TWFPTYLVQERGLSI-LEAGFMASLPGIVGFIGMILGGRLSDLLLRRgkslvfaRKTAIIAGLVLSLLMFATNYVNIPYA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 332 IVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLI 411
Cdd:TIGR00893 315 ALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALS 394
|
....
gi 481041873 412 IFTL 415
Cdd:TIGR00893 395 YLLL 398
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
16-413 |
1.02e-56 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 192.08 E-value: 1.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 16 RLIPFMLALYVLAFLDRSNIGFAK-QTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFL 94
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 95 SAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHGFMGHPG 174
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLAG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 175 WFWMFVIEGLLAVGAGVFTFFWLDDTPGQARFLSKQEKTLLI-----NQLASEEQQKVTSRLSDALRNGRVWQLAIIYLT 249
Cdd:cd17327 165 WRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVerlraNQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFC 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 250 IQVAVYGLIFFLPTQVAalLGTKVGFTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIG-IGLSGLLSP 328
Cdd:cd17327 245 SQITNNGISNFLPLILK--SLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGsIILLAAPNP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 329 VLAIVALCVAAIGFIAVQPVFWTMPTQLLSG-TALAAGIGFVNLFGAVGGFIAPILrvkaetLFSSDA----AGLLTLAA 403
Cdd:cd17327 323 PGAYFAAYILGGGSYAGFPILLSWISSNCAGyTKRATVLAIMLIFYNVGNIVAPQI------FRAGDApryiPGNIALLV 396
|
410
....*....|
gi 481041873 404 VAVIGSLIIF 413
Cdd:cd17327 397 CACVSIVLSV 406
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-416 |
1.97e-49 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 171.59 E-value: 1.97e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 7 DAVVKKNRARLIPFMLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGT 86
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 87 TTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEM 166
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 167 HgfmghpGWFWMFVIEGLLAVGAGVFTFfwlddtpgqarflskqektllinqlaseeqqkvtsrlsdalrngrvWQLAII 246
Cdd:COG2271 161 F------GWRAAFLILGLPGLLLALLRF----------------------------------------------WLLALA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 247 YLTIQVAVYGLIFFLPTQVAALLGTKVGfTASVVTAIPWVAALFGTWLIPRYSDKTGERR-NVAALTLLAAGIGIGLSGL 325
Cdd:COG2271 189 YFLVYFALYGFLTWLPTYLVEVRGLSLA-QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 326 L-SPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAgLLTLAAV 404
Cdd:COG2271 268 LpSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA-FLLLAAL 346
|
410
....*....|..
gi 481041873 405 AVIGSLIIFTLR 416
Cdd:COG2271 347 ALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-417 |
4.28e-38 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 141.94 E-value: 4.28e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 12 KNRARLIPFMLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLW 91
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 92 GFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHgfmg 171
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 172 hpGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARflskqektllinqlasEEQQKVTSRLSDALRNGRVWQLAIIYLTIQ 251
Cdd:COG2223 157 --GWRNAFLILGILLLVVAVLAWLFLRDPPAGAA----------------AAAKASLRDQLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 252 VAVYGLIFFLPTQVAALLGTKVGfTASVVTAIPWVAALFGTWLIPRYSDKTGERR-NVAALTLLAAGIGIGLSGLLSPVL 330
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAA-TAGLLAALFALLGALGRPLGGWLSDRIGGRRvLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 331 AIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSL 410
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
....*..
gi 481041873 411 IIFTLRV 417
Cdd:COG2223 378 LTLLLYR 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-413 |
4.05e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 108.67 E-value: 4.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 21 MLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAW 100
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 101 ADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHGFmghpGWFWMFV 180
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 181 IEGLLAVGAGVFTFFWLDDTPGQARflskqektlliNQLASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFF 260
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESAR-----------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 261 LPTQVAALLGtKVGFTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPV-LAIVALCVAA 339
Cdd:cd06174 226 LPLFLLDLGG-LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLlLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481041873 340 IGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLIIF 413
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-380 |
1.51e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.52 E-value: 1.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 11 KKNRARLIPFMLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLL 90
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 91 WGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfm 170
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD----- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 171 gHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARflskqektllinqlaseeqQKVTSRLSDALRNGRVWQLAIIYLTI 250
Cdd:COG2814 160 -LFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR-------------------ARLRGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 251 QVAVYGLIFFLPTQVAALLGTKVGfTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVL 330
Cdd:COG2814 220 GFGFFALFTYLPLYLQEVLGLSAS-AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 481041873 331 AIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIA 380
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-381 |
3.89e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.50 E-value: 3.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 21 MLALYVLAFLDRSNIGFA-KQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMA 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 100 WADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHPGWFWMF 179
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 180 VIEGLLAVGAGVFTFFWLDDTPGQarflskqektlliNQLASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIF 259
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESK-------------RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 260 FLPTQVAALLGTKvgFTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGL---SGLLSPVLAIVALC 336
Cdd:pfam07690 222 YLPLYQEVLGLSA--LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLlllSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 481041873 337 VAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAP 381
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
47-417 |
7.44e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.63 E-value: 7.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 47 GLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMI 126
Cdd:cd17325 27 GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 127 YLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARf 206
Cdd:cd17325 107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD------ALGYRAPFLVCAALALLALVLALLLLPEPRPPPN- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 207 lskqektllinqLASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGFTASVVTAIPwV 286
Cdd:cd17325 180 ------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG-L 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 287 AALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGI 366
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 481041873 367 GFVNLFGAVGGFIAPILRVKAETLFSsdAAGLLTLAAVAVIGSLIIFTLRV 417
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDAFG--FATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
45-415 |
1.25e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 87.24 E-value: 1.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 45 DTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPG 124
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 125 MIYLTSQWFPQRnRASIMGLFYMGAPLALTLGSPLSGALlemhgfMGHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPgqa 204
Cdd:COG2807 127 LPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPL------AAALGWRGALAVWALLALLALLLWLPLLRRRP--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 205 rflskqektllinqlASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVgfTASVVTAIP 284
Cdd:COG2807 197 ---------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAA--TAGLLLSLF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 285 WVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAA 364
Cdd:COG2807 260 QLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAA 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 481041873 365 GI-GFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLIIFTL 415
Cdd:COG2807 340 ALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
25-381 |
4.90e-17 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 82.04 E-value: 4.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 25 YVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTE 104
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 105 AKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHGfmghpGWFWMFVIEGL 184
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY-----SWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 185 LAVGAGVFTFFWLDDTPgQARFLSKQEK-----TLLINQLASEEQQKVTSRLSDALRNGRVWQLAIIYltiqVAVYGLIF 259
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSP-QSCGLPPAEEmpneePDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGY----VFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 260 FLPTQVAALLGTKVGFT---ASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVLA---IV 333
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSkekASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAAnplMD 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 481041873 334 ALCVAAIGFIAVQPV--FWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAP 381
Cdd:TIGR00881 314 LICLFALGFLVYGPQmlIGVIASELAPKKAAGTAAGFVGFFAYLGGILAG 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
45-380 |
3.90e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.43 E-value: 3.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 45 DTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPG 124
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 125 MIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQA 204
Cdd:cd17324 108 AAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ------LLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 205 RFlskqektllinqlaseeQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGFtASVVTAIP 284
Cdd:cd17324 182 PG-----------------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSA-IIGLLLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 285 WVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLL---SGTA 361
Cdd:cd17324 244 GVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLApeaRGLA 323
|
330
....*....|....*....
gi 481041873 362 LAAGIGFVNLFGAVGGFIA 380
Cdd:cd17324 324 SSLYLAAYNLGGALGAALG 342
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
43-412 |
3.63e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 73.43 E-value: 3.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 43 QIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFF 122
Cdd:cd17475 23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 123 PGMIYLTSQWFPQRNRASIMGLFYMGAPlaltLGSPLSGALLEmhGFMGHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPG 202
Cdd:cd17475 103 PGGGRAIMRWFPPRERGLAMGIRQTGVP----LGGALAAALLP--PLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 203 QARflskqektllinqlASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGfTASVVTA 282
Cdd:cd17475 177 ASA--------------ATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVV-AAGALLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 283 IPWVAALFGTWLIPRYSDK--TGERRNVAALTLLAAGIGIGLSGLLSPV--LAIVALCVAAIGFIAV--QPVFWTMPTQL 356
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGtpLWLLVLLLILLGLFAIgwNGLYLTLVAES 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 481041873 357 LSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLII 412
Cdd:cd17475 322 AGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
42-383 |
8.38e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.24 E-value: 8.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 42 YQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGF 121
Cdd:cd17489 22 YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 122 FPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALlemhgfMGHPGWFWMFVIEGLLAVGAGVFTFFWLDDTP 201
Cdd:cd17489 102 TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL------YQHLGFAVLFIVAAVLALLALLLVFLVKDPPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 202 gqarflskqektllinqlASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGFtASVVT 281
Cdd:cd17489 176 ------------------VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL-FFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 282 AIpwvAALFGTWLIPRYSDKTGERRnVAALTLLAAGIGIGLSGLL-SPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGT 360
Cdd:cd17489 237 AI---ALLLSRPFSGKLSDRKGPKT-VIIPGLLLLALGLLLLSFAgSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340
....*....|....*....|...
gi 481041873 361 ALAAGIGFVNLFGAVGGFIAPIL 383
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLL 335
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
21-413 |
7.40e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.57 E-value: 7.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 21 MLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAW 100
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 101 ADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHGfmghpGWFWMFV 180
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRWAFR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 181 IEGLLAVGAGVFTFFWLDDTPGQARFLSKQEKTLLINQLASeeqqkvtsrLSDALRNGRVWQLAIIYLTIQVAVYGLIFF 260
Cdd:cd17328 159 VTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 261 LPT------QVAALLGTKVGFTASVVTAIpwvAALFGTWLIPRYSDKTGERRN-----VAALTLLAAGIGIGLSGLLSPV 329
Cdd:cd17328 230 APTfflrafGVGDLSSADVGLIFGAITCI---AGVLGVLLGGILADRLRRKTPradplVCAVGLLAAAPFLFLALVLALS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 330 LAIVALCVAAIGFIAVQPVFWTMPTQLLS-------GTALAAGIGFVNLFG-----AVGGFIAPILRVKAETLFSSDAA- 396
Cdd:cd17328 307 NLLLAWVLLFLGEFLLSLNWAPVFAILLYvviptrrSTASAIQILLSHLLGdagspYLIGLISDLLRQNKDSPLAEAASl 386
|
410
....*....|....*....
gi 481041873 397 --GLLTLAAVAVIGSLIIF 413
Cdd:cd17328 387 qyALLLCSFVLVLGGFFFL 405
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
77-383 |
1.06e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 69.31 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 77 KLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLG 156
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 157 SPLSGALLEMHgfmghpGWFWMFVIEGLLAVGAGVFTFFWLddtPGQARFL-SKQEKTLL--INQLASEEQQKVTSRLSD 233
Cdd:TIGR00895 158 GFLAGWLIPVF------GWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLvSKRPETVRriVNAIAPQMQAEAQSALPE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 234 ALRNGRVWQ-----------------LAIIYLTIQVAVYGLIFFLPTqvaalLGTKVGFTAS---VVTAIPWVAALFGTW 293
Cdd:TIGR00895 229 QKSTQGTKRsvfkalfqgktaritvlLWLLYFMLLVGVYFLTNWLPK-----LMVELGFSLSlaaTGGALFNFGGVIGSI 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 294 LIPRYSDKTGerRNVAALTLLAAGI--GIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNL 371
Cdd:TIGR00895 304 IFGWLADRLG--PRVTALLLLLGAVfaVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIG 381
|
330
....*....|..
gi 481041873 372 FGAVGGFIAPIL 383
Cdd:TIGR00895 382 IGRLGAIIGPIL 393
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
25-416 |
1.02e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 65.76 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 25 YVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTE 104
Cdd:cd17312 12 YAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 105 AKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALlemhgfMGHPGWFWMFVIEGL 184
Cdd:cd17312 92 WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASL------ASYYGWRAAFLVPGI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 185 LAVGAGVFTFFWLDDTPGqarflskqektllinqlaseeqqkvtsrlsdalrngRVWQLAIIYLTIQVAVYGLIFFLPTQ 264
Cdd:cd17312 166 VGLVVAIILFFFLRDSPP------------------------------------YVWVLSLAYAFVYIVRYACLDWGPLY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 265 VAALLGTKVGFTASVVTAIPwVAALFGTWLIPRYSDKT--GERRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGF 342
Cdd:cd17312 210 LYEVKGYSLIDAGWFSSLYE-VGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGF 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 481041873 343 IAVQPV-FWTMPTQLLSGTALAAG--IGFVNLFGAVGGFIAPILRVKAETLFSSDAAgLLTLAAVAVIGSLIIFTLR 416
Cdd:cd17312 289 FVGGPInLIGGAAAQDIGRKEAAGtaTGFVGLFGYLGASLAGLPLGYIIDHYGWSTV-FYFLISAALLSVLLLLSLW 364
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
65-416 |
1.14e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 65 AFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGL 144
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 145 FYMGAPLALTLGSPLSGALLEMhgfmghpGWFWMFVIEgLLAVGAGVFTFFWLDDTPGqarflskqektllinqlASEEQ 224
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAEI-------GWRAPFLVY-LLALPVLILVLLFLPEPAR-----------------KSKSA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 225 QKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKvGFTASVVTAIPWVAALFGTWLIPRYSDKTGE 304
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS-AALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 305 RRnVAALTLLAAGIGIGLSGLLSPVLAIVALCVAA-IGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPIL 383
Cdd:cd17473 263 RR-LLAIGFALMALGFLLLALASGLWVVLLGAILAgLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|...
gi 481041873 384 RVKAETLFSSDAAGLLTLAAVAVIGSLIIFTLR 416
Cdd:cd17473 342 LGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
57-383 |
3.48e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.46 E-value: 3.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 57 AGIFFVVYAFLGVPANLLM--------RKLGART-WIGTTTLLWGFLSAAMAWADTEAK------FLIVRTLLGAAEAGF 121
Cdd:COG2211 48 VGLILLVARLWDAITDPLIgalsdrtrTRWGRRRpWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 122 FPGMIYLTSQWFP-QRNRASIMGLFYMGAPLALTLGSPLSGALLEMHGFMGHPGWFWMFVIEGLLAVGAGVFTFFWLDDT 200
Cdd:COG2211 128 NIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKER 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 201 PgqarflskqektllinqLASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGFtASVV 280
Cdd:COG2211 208 P-----------------VPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAL-VGLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 281 TAIPWVAALFGTWLIPRYSDKTGeRRNVAALTLLAAGIG---IGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLL 357
Cdd:COG2211 270 LALYFLAALLGAPLWPRLAKRFG-KKKAFIIGLLLAALGlllLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
330 340 350
....*....|....*....|....*....|...
gi 481041873 358 SGTALAAGI-------GFVNLFGAVGGFIAPIL 383
Cdd:COG2211 349 DYDEWKTGRrreglyfGIFTFAIKLGQALAGAL 381
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
45-415 |
7.80e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 60.36 E-value: 7.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 45 DTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPG 124
Cdd:cd17355 32 EFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 125 MIYLT-SQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHPGWFWMFVIEGLLAVGAGVF-TFFWLDDTPG 202
Cdd:cd17355 112 VAFATvAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE------AFGWRTALLVLALLALLVLVPvLLLLRRRPAD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 203 QARFLSKQEKTllinqlaseeqQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVgfTASVVTA 282
Cdd:cd17355 186 LALRAYDDASP-----------ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPA--AAAVALA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 283 IPWVAALFGTWLIPRYSDKTGERRNVAALTLL-AAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTA 361
Cdd:cd17355 253 LIGLFNIVGRLLSGWLGDRYSPRRLLAASYALrALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARS 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 481041873 362 LAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLIIFTL 415
Cdd:cd17355 333 YGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-420 |
2.17e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 11 KKNRARLIPFMLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLL 90
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 91 WGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPqRNRASIMGLFYMGAPLALTLGSPLSGALLEMHgfm 170
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLG--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 171 GHPGWFWMFVIegLLAVGAGVFTFFWLDDTPGQARflskqektllinqlASEEQQKVTSRLSDALRNGRVWQLAIIYLTI 250
Cdd:COG0738 159 LSLSWHLPYLI--LAVLLLLLALLFLRSKLPEIEE--------------EEEEAAGSAASLKSLLKNPRLLLGGLAIFLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 251 QVAVYGLIFFLPTQVAALLGTKVGfTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVL 330
Cdd:COG0738 223 VGAEGAIGDWLPLYLKDVLGLSEA-TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 331 AIVALCVAAIGFIAVQPVFWTMPTQLLsGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSL 410
Cdd:COG0738 302 ALIGLALVGLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
410
....*....|
gi 481041873 411 IIFTLRVNRT 420
Cdd:COG0738 381 ALALKRKRRK 390
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
65-414 |
3.11e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.42 E-value: 3.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 65 AFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTE-AKFLIVRTLLGAAEAGFFPGMiYLTSQWFPQRNRASIMG 143
Cdd:cd17341 48 ALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSyWGLLVLGFLLGFAGANFASGQ-PWASFWFPKEKIGGAAG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 144 LFY----MGAPLALTLGSPLSGALLEMHGFMGhpgWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARFlskqektllinql 219
Cdd:cd17341 127 GIAgagnMGVAVSQLLAPLIAGAIVFDGGFVG---WRNAFFVPGILLAIAAVLVLLFGDDLPTGKAS------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 220 aseeQQKVTSRLSDALRNGRVWQLAIIY-------LTIQVAVYGLI---FFLPTQVAALLGTKVGFTASVVTAIpwvaal 289
Cdd:cd17341 191 ----ALEFLKVQLAVLKNYRTWILSLLYgvtfgsfVGFSNVLPTYFktrFGLPLVTAGILAALFPLAGALARPA------ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 290 fGTWLiprySDKTGERRNVAAL--TLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQ--LLSGTALAAG 365
Cdd:cd17341 261 -GGWL----SDRFGGRRRLWWLfiVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMvpFIFRRELGAV 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 481041873 366 IGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLIIFT 414
Cdd:cd17341 336 TGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-412 |
3.95e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.08 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 25 YVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTE 104
Cdd:cd17371 8 WALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 105 AKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMhgFMGHPGWFWMFVIeGL 184
Cdd:cd17371 88 WQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPL--LPPEIAWRVLFLL-GA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 185 LAVGAGVFTFFWLDDTPgqaRFLSKQEKtllinqlASEEQQKVTSRLSDALRNGRVWQLAIIYLT-IQVAVYGLIFFLPT 263
Cdd:cd17371 165 LPALLVLFIRRFVKEPP---QWQAARAA-------RRHFADRPSLRELFSPPLLRTTLLASLLATgALGGYYGITTWLPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 264 QVAALLGTKVGfTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAgIGIGLSGLLSPVLAIVALCVAAIGFI 343
Cdd:cd17371 235 YLTGERGLSFE-GSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSA-ISILLYFFLPLSPTLILILGFPLGFF 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 481041873 344 AVQP--VFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILrVKAETLFSSDAAGLLTLAAVAVIGSLII 412
Cdd:cd17371 313 ASGPfsGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFL-VGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
60-197 |
4.21e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 57.95 E-value: 4.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 60 FFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAW-ADTEAKFLIV-RTLLGAAEAGFFPGMIYLTSQWFPQRN 137
Cdd:cd17380 43 FFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLlAYSSLPLLILsRILLGLGEGVHFPSMTSLFSRWVPVSE 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 138 RASIMGLFYMGAPLALTLGSPLSGALLEMHgfmghpGWFWMFVIEGLLAVgagVFTFFWL 197
Cdd:cd17380 123 RSRAVSIVTAGSYLGTLLGGLIGPLLLEYY------GWPSVFYFFGLLGL---LWALVWL 173
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
60-383 |
5.17e-09 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 57.63 E-value: 5.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 60 FFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAW-ADTEAKFLIV-RTLLGAAEAGFFPGMIYLTSQWFPQRN 137
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLaARGGYGALIVlRILQGLAQGVTFPAMHALWAKWAPPLE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 138 RASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHPGWFWMFVIEGLLAVgagVFTFFWLddtpgqarFLSKQektllin 217
Cdd:cd17318 145 RSRLTSIAYSGSQFGTVIAMPLSGFLCE------SLGWPSIFYIFGGLGL---LWCLLWF--------FLVLP------- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 218 qlaseeqqkvtsrlsdalrngrVWQLAIIYLTIQVAVYGLIFFLPTQVAALLG---TKVGFTASVVTAIPWVAALFGTWL 294
Cdd:cd17318 201 ----------------------VWAIVVAHFGHNWGFYTLLTELPTYMSDVLHfniKSNGFLSSLPYLAMWICSIVGGYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 295 iprySDKTGERRNVAALTL--LAAGIGIGLSGLL---------SPVLAIVALCVaAIGFI-AVQPVFwtmptqLLSGTAL 362
Cdd:cd17318 259 ----ADWLRSRGILSTTTVrkLFTSIGFLGPGVFlialgylgsNATLAVVFLTL-SVGLSgACYSGF------LVNHLDL 327
|
330 340
....*....|....*....|....*.
gi 481041873 363 A---AGI--GFVNLFGAVGGFIAPIL 383
Cdd:cd17318 328 ApnyAGTlmGITNTAATIAGIISPLI 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
77-419 |
2.04e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 55.67 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 77 KLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLG 156
Cdd:cd17365 60 RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 157 SPLSGALLEmhgfmgHPGWFWMFVIEGLLAVGAGVFTFfwlddtpgqarflskqeKTLLinqlaseeqqkvtsrlsdalr 236
Cdd:cd17365 140 GFLAAALIP------AFGWRSVFLLGGVPPLILLPLLR-----------------GTLL--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 237 ngrvwqLAIIYLTIQVAVYGLIFFLPTqvaalLGTKVGFT---ASVVTAIPWVAALFGTWLIPRYSDKTGeRRNVAALTL 313
Cdd:cd17365 176 ------LWVTFFMGLLLVYLLNSWLPK-----LMVEAGYSlsqALTITLLLNIGGVIGSLLLGWLADRFG-PKRVLALFF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 314 LAAGIGIGLSGLLSPVLAIVALCVAAIGF--IAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLF 391
Cdd:cd17365 244 ALGAVSLALLGVSPASLVLLYVLVFLAGAcvNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAG 323
|
330 340
....*....|....*....|....*...
gi 481041873 392 SSDAAGLLTLAAVAVIGSLIIFTLRVNR 419
Cdd:cd17365 324 LGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
77-413 |
1.64e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.99 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 77 KLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLG 156
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 157 SPLSGALLEMhgFMGHPGWFWMFVIEGLLAVGAGVFtffwlddtpgqarflskqektllinqlaseeqqkvtsrlsdalr 236
Cdd:cd17316 142 ALVASLLIPL--LSGDWGWRILFLIGALPALLALLL-------------------------------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 237 NGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGfTASVVTAIPWVAALFGTWLIPRYSDKTGERR--NVAALTLL 314
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPA-TSSLYLLLISLGALVGALIAGLLSDRIGRKKtlVIGLILSG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 315 AAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSD 394
Cdd:cd17316 255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
330
....*....|....*....
gi 481041873 395 AAGLLTLAAVAVIGSLIIF 413
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
120-377 |
2.01e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 52.63 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 120 GFFPGMIYLTSQ-----WFPQRNRASIMGLFYMGAPLALTLGSPLSGALLemhGFMGHPGWFWMFVIEGLLAVGAGVFTF 194
Cdd:cd17345 106 GWFQGMGWPPSGrtmvhWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL---AIFGDGWWRGAFIFPAIIAIIVAVIVL 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 195 FWLDDTPgQARFLSKQEKTL--LINQLASEEQQKVTSR----LSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAAL 268
Cdd:cd17345 183 FLGKDTP-ESEGLPPIEEYKgdYPEEADGEEEEQELSAweifVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEV 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 269 LGTKVGfTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGL-LSPVLAIVALCVAAIGFIAVQP 347
Cdd:cd17345 262 KGFSKA-QAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYwLAPNVLVDLIALIALGFLIYGP 340
|
250 260 270
....*....|....*....|....*....|..
gi 481041873 348 VFWT--MPTQLLSGTALAAGIGFVNLFGAVGG 377
Cdd:cd17345 341 VMLIglQALELVPKKAAGTAAGLTGLFGYLGG 372
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
60-399 |
5.02e-07 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 51.67 E-value: 5.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 60 FFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIV--RTLLGAAEAGFFPGMIYLTSQWFPQRN 137
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVfcRVIQGLAQGSVSPATHKIIVKWAPPKE 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 138 RASIMGLFYMGAPLALTLGSPLSGALLEMHGfmghpGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARFLSKQEKTLLIn 217
Cdd:TIGR00894 165 RSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYIN- 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 218 qlASEEQQKVTSRLSDALRNGRVW-QLAIIYLTIQVAVYG---LIFFLPT---QVAALLGTKVGFTASVVTAIPWVAALF 290
Cdd:TIGR00894 239 --SSLQGQKGSTRQSLPIKAIPKSlPVWAIWFAIFGHFWLytiLPTYLPTfisWVLRVSGKENGLLSSLPYLFAWLCSIF 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 291 GTWLIpRYsDKTGERRNVAALTLLAAGIGIglsglLSPVLAIVALCVAAIGFIAVQpVFWTMPTQLLSGTALAAGIGFVN 370
Cdd:TIGR00894 317 AGYLA-DF-LKSSKTLSLTAARKIFNGIGG-----LGPGIFAYALPYLSAAFYLTI-IILTLANAVSSGPLAGVLINSLD 388
|
330 340 350
....*....|....*....|....*....|.
gi 481041873 371 LFGAVGGFIAPILRVKAET--LFSSDAAGLL 399
Cdd:TIGR00894 389 LAPRFLGFIKGITGLPGFIggLIASTLAGNI 419
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
57-383 |
1.17e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 57 AGIFFVVYAFLGVPANL----LMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQW 132
Cdd:cd17329 37 VGLVLALSAVAGIVASLiggrLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 133 FPQRNRASIMGLFYMGAPLALTLGsPLSGALLEMHGFmghpgwFWMFVIEGLLAVGAGVFTFFWLDDTpgqarflskqek 212
Cdd:cd17329 117 TTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSF------RLLFLAAAVLFLLAALVLLFLLPET------------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 213 tllINQLASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGFTASVVTAIPWVAALFGT 292
Cdd:cd17329 178 ---RPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 293 WLIPRYSDKTGERRNVAALTLLAAGIGIgLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLF 372
Cdd:cd17329 255 PVARLVERFRLRKILMIGILLFAIGFAV-LAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALA 333
|
330
....*....|.
gi 481041873 373 GAVGGFIAPIL 383
Cdd:cd17329 334 WGLGRAIGPLV 344
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-291 |
1.56e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.42 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 6 LDAVVKKNRARLIPFMLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIG 85
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 86 TTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLE 165
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 166 mhgfmgHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARFLSKQEKTLLINQLASEEQQKVTSRLSDALRNGRVWQLAI 245
Cdd:COG0477 164 ------ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 481041873 246 IYLTIQVAVYGLIFFLPTQVAALLGTKVGFTASVVTAIPWVAALFG 291
Cdd:COG0477 238 ALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLL 283
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
71-416 |
3.85e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 48.84 E-value: 3.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 71 ANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAP 150
Cdd:cd06180 54 ASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 151 LALTLGSPLSGALLEmHGFMGHPGWFWMfvieGLLAVGAGVFTFFWLDDTPGQARFlskqektllinqlaseeqqkVTSR 230
Cdd:cd06180 134 LGIALSGLLVPAGLG-GGLSWRAGWLAL----ALLSAVLLLLSFLLLRRGPSAPTE--------------------ASAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 231 LSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAallgtkVGFTASVVTAIPW----VAALFGTWLIPRYSDKTGERR 306
Cdd:cd06180 189 ESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIAR------ETGAGSLLAGLLWslfgLAAVPSCFLWGALSDRWGTRR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 307 NVAAlTLLAAGIGIGLSgLLSPVLAIVALCVAAIGFIAVQPVFWTMP-TQLLSGTALAAGIGFVNLFGAVGGFIAPILRV 385
Cdd:cd06180 263 ALAA-NLLVQAVGVLLP-LLSPGPAGLVLSAVLFGGTFMAITALVMAlARELAPPAAPRALALMTASFGVGQILGPLLAG 340
|
330 340 350
....*....|....*....|....*....|.
gi 481041873 386 KAETLFSSDAAGLLTLAAVAVIGSLIIFTLR 416
Cdd:cd06180 341 WLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-415 |
3.96e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 3.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 59 IFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNR 138
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGER 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 139 ASIMGLFYMgaplALTLG---SPLSGALLEMHGfmghpgWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARFLSKQEKTLL 215
Cdd:cd17474 122 AKAMGLYEA----ALGLGiavGPLLGGLLAAIS------WRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 216 INqlaseeqqkvtsrlsdALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVG------FTASVVTAIpwVAAL 289
Cdd:cd17474 192 KK----------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIiigllfAGWSVLLAL--GSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 290 FGTWLIPRYSDKtgeRRNVAALTLLAAGIGIgLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFV 369
Cdd:cd17474 254 VGRLLKKRFGAR---RILVIGLLLYALSLLL-LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLY 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 481041873 370 NLFGAVGGFIAPILRVKAETLFSSDAAgLLTLAAVAVIGSLIIFTL 415
Cdd:cd17474 330 NFVRFLGQAVGPLLFGLLLEIFGLSAP-FLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
58-195 |
5.40e-06 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 48.24 E-value: 5.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 58 GIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAW-ADTEAKFLI-VRTLLGAAEAGFFPGMIYLTSQWFPQ 135
Cdd:cd17381 72 GSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLaADLGAGYLIaVRALEGLGEGVTFPAMHAMWASWAPP 151
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 136 RNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHPGWFWMFVIEGllavGAGVFTFF 195
Cdd:cd17381 152 LERSRLLTISYAGAQLGTVVSLPLSGLICY------YLDWTYVFYIFG----AVGLLWFF 201
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
14-201 |
3.67e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 45.47 E-value: 3.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 14 RARLIPFMLALYVLAFLDRSNIGFAKQTYQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGF 93
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 94 LSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHP 173
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAAL------TY 154
|
170 180
....*....|....*....|....*...
gi 481041873 174 GWFWMFVIEGLLAVGAGVFTFFWLDDTP 201
Cdd:cd17488 155 GWRAGMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
45-377 |
3.82e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 45.37 E-value: 3.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 45 DTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWA-DTEAKFLIVRTLLGAAEAGFFP 123
Cdd:TIGR00886 31 DLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGSFAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 124 GMiYLTSQWFPQRNRASIMGLF----YMGAPLALTLGSPLSGALLEMHGFMGHPGWFWMFVI--EGLLAVGAGVFTFFWL 197
Cdd:TIGR00886 111 CM-PWISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIvpAGILLLPALLIFFVGA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 198 DDTPGQarflskqektllinqlaSEEQQKVTSRLSDALRNGRVWQLAIIYltiqVAVYGLIFFLPTQVAALLGTKVGFTA 277
Cdd:TIGR00886 190 DTPPGK-----------------PATGKLSFKEALKVFGNRHTWILALLY----SVTFGSFLGVSSIFAMLFKDQFGLSK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 278 SVVTAIPWVAALFGTWLIP---RYSDKTGERR----NVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGF-IAVQPVF 349
Cdd:TIGR00886 249 VQAGAYASLGGFLGSLARPaggAISDRLGGARkllmNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAgAGNGSTF 328
|
330 340
....*....|....*....|....*...
gi 481041873 350 WTMPtqLLSGTALAAGIGFVNLFGAVGG 377
Cdd:TIGR00886 329 ALVP--HIFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
107-206 |
4.16e-05 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 45.39 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 107 FLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMhgfmghpGWFWMFVIEGLLA 186
Cdd:cd17344 123 FVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSS-------AWGLSFIVPGIII 195
|
90 100
....*....|....*....|.
gi 481041873 187 VGAGVFTFFWL-DDTPGQARF 206
Cdd:cd17344 196 AAMGVLVFLFLvEHPPGVIEF 216
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-413 |
6.56e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 6.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 47 GLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMI 126
Cdd:cd17478 27 GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 127 YLTSQWFPqRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgFMGHPGWFWMFVIEGLLAVgagVFTFFWLDDTPgqarf 206
Cdd:cd17478 107 RLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVA---LFGGLGLLILLIIPGLAVA---LLLLRLRPLKK----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 207 lskqektllinQLASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVgfTASVVTAIPWV 286
Cdd:cd17478 175 -----------PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV--FAGLLLSLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 287 AALFGTWLIPRYSDKTGeRRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLL-SGTALAAG 365
Cdd:cd17478 242 AGAIGTLIGGPLSDRFG-RRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLpGNVGLASG 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 481041873 366 I--GFVNLFGAVGGFIAPILrvkaetlfsSDAAGL----LTLAAVAVIGSLIIF 413
Cdd:cd17478 321 LmmGLSFGLGGIGAPVLGAL---------ADAFGLesvlLILALLPLLGALLAF 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
74-328 |
1.02e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.10 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 74 LMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLAL 153
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 154 TLGSPLSGALLEmhgfmgHPGWFWMFVIegLLAVGAGVFTFFWLDDTpgqarflskqektllinqlaseeqqkvtsrlsD 233
Cdd:cd17503 134 AIGPTLGGWLTD------NLSWRWIFYI--NLPIGILALLLAPLLDL--------------------------------R 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 234 ALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVgFTASVVTAIPWVAALFGTWLIPRYSDKTGERRnVAALTL 313
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA-FESGLVLAPGGLASAILSPLVGRLLDKFGPRL-LLLAGL 251
|
250
....*....|....*
gi 481041873 314 LAAGIGIGLSGLLSP 328
Cdd:cd17503 252 LLLALGTLLLAFLTP 266
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
20-427 |
1.46e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.80 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 20 FMLALyvLAFLDRSNIGFAKQTYQIDTGLSNE--AYALGAGIF-FVVYAFLGvpaNLLMRKLGARTWIGTTTLLWGFLSA 96
Cdd:PRK11551 21 FLVAL--LEGLDLQSAGVAAPRMAQEFGLDVAqmGWAFSAGILgLLPGALLG---GRLADRIGRKRILIVSVALFGLFSL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 97 AMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALlemhgfMGHPGWF 176
Cdd:PRK11551 96 ATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLA------AGDAAWR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 177 WMFVIEGLLAVGAGVFTFFWLDDTPG-QARFLSKQEKTLLINQLASEEqqkvtsrlsdalRNGRVWQLAIIYLTIQVAVY 255
Cdd:PRK11551 170 HIFYVGGVGPLLLVPLLMRWLPESRAfAQAAGAGKQRAPVLRALFGEG------------RATATLLLWISYFFTLIVLY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 256 GLIFFLPTQVAALlgtkvGFT---ASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAaltLLAAGIGIGLSGL-LSPVLA 331
Cdd:PRK11551 238 FLLNWLPSLLVGQ-----GLSrsqAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVL---LIYAGILASLAALaAAPSFA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 332 IVALCVAAIGF--IAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGS 409
Cdd:PRK11551 310 GMLLAGFAAGLfvVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASIPVILVAA 389
|
410
....*....|....*...
gi 481041873 410 LIIFTLrVNRTVAQTDVA 427
Cdd:PRK11551 390 LAALLL-VSRPSRADPCA 406
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
107-383 |
2.20e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.47 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 107 FLIVRTLLGAAEAGFFPGMIYLTSQWFP--QRNRASIM-GLFYMGAPLALtlgsPLSGALLemhgfmghPGWFWMfvieg 183
Cdd:TIGR00898 183 FLVFRLLVGMGIGGIWVQAVVLNTEFLPkkQRAIVGTLiQVFFSLGLVLL----PLVAYFI--------PDWRWL----- 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 184 LLAVGAGVFTF----FWLddtPGQARFLSKQ-----------------EKTLLINQLASEEQQKVTSRLSDA--LRNGRV 240
Cdd:TIGR00898 246 QLAVSLPTFLFfllsWFV---PESPRWLISQgrieealkilqriakinGKKLPAEVLSLSLEKDLSSSKKQYsfLDLFRT 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 241 WQLA-------IIYLTIQVAVYGLIFFLPtqvaaLLGTKVGFTASVVTAIPWVAALFGTWLIPRYSdktgeRRNVAALTL 313
Cdd:TIGR00898 323 PNLRkttlclmMLWFTTAFSYYGLVLDLG-----NLGGNIYLDLFISGLVELPAKLITLLLIDRLG-----RRYTMAASL 392
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 481041873 314 LAAGIGIGLSGLLSPVLA--IVALCVAAIGFI--AVQPVFwtMPTQLLSGTAL-AAGIGFVNLFGAVGGFIAPIL 383
Cdd:TIGR00898 393 LLAGVALLLLLFVPVDLYflRTALAVLGKFGItsAFQMVY--LYTAELYPTVVrNLGVGVCSTMARVGSIISPFL 465
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-383 |
3.72e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 47 GLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPGMI 126
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 127 YLTSQWFPQRNRASIMGLFYMgaplALTLGSPLSGALLemhGFMGHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQARf 206
Cdd:cd17477 107 SWLNALATNENRGRVLGLYST----VLGLGFALGPLLL---ALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEA- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 207 lskqektllinqlaseeqqkvtsrlsDALRNGRVWQLAIIYLTIqVAVYGLIFFLPTQVAALLGTKVGFTASVVTAIPWV 286
Cdd:cd17477 179 --------------------------ESISLRRLLRIAPLALLG-AFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 287 ---AALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFI-AVQPVFWTMPTQLLSGTAL 362
Cdd:cd17477 232 fvlGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAgPLYTLALALAGDRLPGDEL 311
|
330 340
....*....|....*....|.
gi 481041873 363 AAGIGFVNLFGAVGGFIAPIL 383
Cdd:cd17477 312 VAANAALLLLYGLGSVIGPLL 332
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
47-196 |
4.25e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 47 GLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAK--FLIVRTLLGAAEAGFFPG 124
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLwlLLVLAALAGIGLGAILVL 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 125 MIYLTS-------QWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHGFMGHPG---------WFWMFVIEGLLAVG 188
Cdd:COG2211 340 PWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAqspsaltgiRLLFFLLPAVLLLL 419
|
....*...
gi 481041873 189 AGVFTFFW 196
Cdd:COG2211 420 AALLLLFY 427
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
108-414 |
4.71e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.13 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 108 LIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSplsGALLEMHGFMGHP-----GWFWMFVIE 182
Cdd:cd17369 109 VLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLAT---GVFLLLSALLSDEaflswGWRIPFLLS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 183 GLLaVGAGVFTFFWLDDTPGQARflskqektllinqlASEEQQKVTSRLSDALRngRVWQLAIIYLTIQVAVYGLIFFLP 262
Cdd:cd17369 186 AVL-VAVGLYIRLRLEETPVFRR--------------AKEAGQVVRAPLVEVLR--RHWRALLLAIGLRLAENVLFYLFT 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 263 TQVAALLGTKVGFTASVVTAIPWVAALFGTWLIP---RYSDKTGERRNVAALTLLAAGIGIGLSGLL---SPVLAIVALC 336
Cdd:cd17369 249 TFALSYATQTLGVDRSTVLLAVLIASVVAAITIPlfgWLSDRVGRRPVYLAGALLAALFAFPFFWLLdtgSTWLIVLAAV 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 337 VaaIGFIAVQPVFWTMPTQL--LSGTAL---AAGIGFvNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLI 411
Cdd:cd17369 329 V--VLGVLHGMMYGPQAAFLaeLFPTRVrytGASLGY-QLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVA 405
|
...
gi 481041873 412 IFT 414
Cdd:cd17369 406 ALF 408
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
95-352 |
4.98e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.16 E-value: 4.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 95 SAAMAWADTEAKFLIVRTLLGAAEAGFFPGMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEmhgfmgHPG 174
Cdd:cd17321 75 SLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE------LFG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 175 WFWMFVIEGLLAVGAGVFTffwlddtpgqarflskqeKTLLINQLASeeqqkvtsrlsdalrngrvwqlaiiyLTIQVAV 254
Cdd:cd17321 149 WRWIFLINVPIGLVALLLA------------------RTFSGAVLAA--------------------------FLLGAAL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 255 YGLIFFLPTQVAALLGTKVGFTASVVTAIPwVAALFGTWLIPRYSDKTGERR-NVAALTLLAAGIGI--GLSGLLSPVLA 331
Cdd:cd17321 185 GGLLFLLPLYLQGVLGYSPLQAGLALLPLA-LAMLVAAPLAGRLADRFGPRLvLVAGLLLTAVGLLLlaLLGADSSVWLL 263
|
250 260
....*....|....*....|.
gi 481041873 332 IVALCVAAIGFIAVQPVFWTM 352
Cdd:cd17321 264 LPGLVLLGLGLGLFATPLTNA 284
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
81-422 |
1.24e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.91 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 81 RTWIGTTTLLWGFLSAAMAWADTEAKFLIVrTLLGAAEAGFFPGMI----YLTSQWFP-QRNRASIMG--LFYMGAPLAL 153
Cdd:COG2270 83 KPFLAFFTLLGVLATAALFFVAPGGLWLGL-LLFVLANIGFEGSLVfynaFLPDIATPeEIGRVSGLGwaLGYLGGVLLL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 154 TLGSplsgALLEMHGFMGHPGWFWM----FVIEGLLAVGAGVFTFFWLDDTPGQARflsKQEKTLLINQLAseeqqKVTS 229
Cdd:COG2270 162 LINL----ALFLKPEAFGLPDAGEAvrisFLLTALWWLLFALPLFLFLPERPRPGP---APPRGAVRAGFR-----ELRR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 230 RLSDALRNGRVWQLAIIYLTIQVAVYGLIFFlptqvAALLGTKV-GFTASVVTA---IPWVAALFGTWLIPRYSDKTGER 305
Cdd:COG2270 230 TLRELRRYRDLLRFLLAYFFYRDGVQTVIAF-----AGIYAAGVlGFSTTELIVfglLVQIVAALGALLFGRLDDRIGPK 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 306 RNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRV 385
Cdd:COG2270 305 RVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFG 384
|
330 340 350
....*....|....*....|....*....|....*..
gi 481041873 386 KAETLFSSDAAGLLTLAAVAVIGSLIIFTLRVNRTVA 422
Cdd:COG2270 385 LVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVPRGRA 421
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
42-416 |
1.26e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.61 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 42 YQIDTGLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGF 121
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 122 -FPGMIYLTSQWFpQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHgfmghpGWFWMFVIEGLLAVGAGVFTffwlddt 200
Cdd:cd17352 109 iYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNY------GWRGALLILGGLCLNLCVCG------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 201 pgqarflskqektllinqlaseeqqkVTSRLsdaLRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALlgtkvGFT---A 277
Cdd:cd17352 175 --------------------------LLLRL---LKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-----GIDesdA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 278 SVVTAIPWVAALFGTWLIPRYSDKTGERR-NVAALTLLAAGIGIGLSGLLS--PVLAIVALCVAAI--GFIAVQPVfwtM 352
Cdd:cd17352 221 AFLLSIIGISDIVGRILLGLLADKPRIGRlYLYIFTLLILGLSLLAFPLATtyVGLIVFSVLFGFCsgSYSSLTPV---I 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481041873 353 PTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDAAGLLTLAAVAVIGSLIIFTLR 416
Cdd:cd17352 298 LADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
52-198 |
1.74e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 40.32 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 52 AYALGAGIFFVVYAFLG--VPANLLMrkLGARTWIGTTTLLWGFlsaamawADTEAKFLIVRTLLGAAEAGFFPGMIYLT 129
Cdd:cd17476 41 SYSLTVGTFILIFGRLGdiYGHKKMF--VIGSFWFAIWSLIAGF-------SPNFIFFIICRALQGLGPAFLLPNAMALL 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 130 SQWFPQRNRASI-MGLFYMGAPLALTLGSPLSGALLEMhgfmghPGWFWMFVIEGLLAVGAGVFTFFWLD 198
Cdd:cd17476 112 GRTYPPGPRKNIvFSLFGATAPLGFALGGVFGGLFAQL------AWWPWIFWFLAILAAIVAVAAIFWTS 175
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-415 |
4.55e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.14 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 49 SNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKF-----LIVRTLLGAAEAGFFP 123
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLslwllLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 124 GMIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLemhgfmGHPGWFWMFVIEGLLAVGAGVFTFFWLDDTPGQ 203
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV------ALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 204 ARflskqektllinQLASEEQQKVTSRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGfTASVVTAI 283
Cdd:cd06173 186 PG------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAA-GYGLLLAA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 284 PWVAALFGTWLIPRYSDKTGERRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTM-----PTQLLs 358
Cdd:cd06173 253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLlqlrvPDELR- 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 481041873 359 GTALAAGIGFVNLFGAVGGFIAPILrvkaeTLFSSDAAGLLTLAAVAVIGSLIIFTL 415
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLL-----ADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
236-424 |
5.69e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 236 RNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTkvGFTASVVTAIPWVAALFGTWLIPRYSDKTGERRNVAALTLLA 315
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS--PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 316 AGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPTQLLSGTALAAGIGFVNLFGAVGGFIAPILRVKAETLFSSDA 395
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180
....*....|....*....|....*....
gi 481041873 396 AGLLTLAAVAVIGSLIIFTLRVNRTVAQT 424
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAARA 194
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
235-376 |
6.26e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 6.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 235 LRNGRVWQLAIIYLTI-QVAVYGLIFFLPTQVAALLGTKVgFTASVVTAIPWVAALFGTWLIPRYSDKTGERR---NVAA 310
Cdd:cd06179 258 LFRGRNFALILIVAFVeGMIFYSLNIFWPQQISLLFTTDP-LKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKwqlVAGF 336
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 311 LTLLAAGIGIGLSGLLSPVLAIVALCVAAIGFIAVQPVFWTMPT----QLLSGTALAAGIGFVNLFGAVG 376
Cdd:cd06179 337 VLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQlsvpPEDIGTASGLLGSARALGGAVG 406
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
54-342 |
6.26e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 54 ALGAGIFFVVYAFLGVPANLLMRKLGARTWIGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGF-FPGMIYLTSQW 132
Cdd:cd17353 41 ALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIgYITPVSTAVKW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 133 FPQRnRASIMGLFYMGAPLALTLGSPLSGALLEMHGFMghpgwfWMFVIEGLLAVGAGVFTFFWLDDTPGQarfLSKQEK 212
Cdd:cd17353 121 FPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVP------TTFLILGIIFLIIIVIGAFLIRDPPKG---WVPPGV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 213 TLLINQLASEEQQKvtsRLSDALRNGRVWQLAIIYLTIQVAVYGLIFFLPTQVAALLGTKVGFTASVVTAIPwVAALFGT 292
Cdd:cd17353 191 DPLANNAENSPRDY---TPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILS-IFNGGGR 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 481041873 293 WLIPRYSDKTGeRRNVAALTLLAAGIGIGLSGLLSPVLAIVALCVAAIGF 342
Cdd:cd17353 267 PFWGWLSDKIG-RKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGF 315
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
47-201 |
6.68e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041873 47 GLSNEAYALGAGIFFVVYAFLGVPANLLMRKLGARTW--IGTTTLLWGFLSAAMAWADTEAKFLIVRTLLGAAEAGFFPG 124
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGL 291
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 481041873 125 MIYLTSQWFPQRNRASIMGLFYMGAPLALTLGSPLSGALLEMHgfmghpGWFWMFVIEGLLAVGAGVFTFFWLDDTP 201
Cdd:COG2271 292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT------GYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| |
