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Conserved domains on  [gi|485650817|ref|WP_001296790|]
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MULTISPECIES: 4Fe-4S binding protein [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10330 super family cl32497
electron transport protein HydN;
1-148 3.68e-64

electron transport protein HydN;


The actual alignment was detected with superfamily member PRK10330:

Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 194.34  E-value: 3.68e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVSHQENQDCAALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHG 80
Cdd:PRK10330   1 MNRFIIADASKCIGCRTCEVACVVSHQENQDCASLTPETFLPRIHVIKGVNVSTATVCRQCEDAPCANVCPNGAISRDKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVS-------------SRKKARAIKCDLCWHRETGPACVEACPTKALQCMDVEKV 147
Cdd:PRK10330  81 FVHVMQERCIGCKTCVVACPYGAMEVVVrpvirnsgaglnvRAEKAEANKCDLCNHREDGPACMAACPTHALICVDRNKL 160


                 .
gi 485650817 148 Q 148
Cdd:PRK10330 161 E 161
 
Name Accession Description Interval E-value
PRK10330 PRK10330
electron transport protein HydN;
1-148 3.68e-64

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 194.34  E-value: 3.68e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVSHQENQDCAALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHG 80
Cdd:PRK10330   1 MNRFIIADASKCIGCRTCEVACVVSHQENQDCASLTPETFLPRIHVIKGVNVSTATVCRQCEDAPCANVCPNGAISRDKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVS-------------SRKKARAIKCDLCWHRETGPACVEACPTKALQCMDVEKV 147
Cdd:PRK10330  81 FVHVMQERCIGCKTCVVACPYGAMEVVVrpvirnsgaglnvRAEKAEANKCDLCNHREDGPACMAACPTHALICVDRNKL 160


                 .
gi 485650817 148 Q 148
Cdd:PRK10330 161 E 161
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 4-142 5.11e-61

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 185.16  E-value: 5.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   4 FIIADATKCIGCRTCEVACAVSHQENQDC-AALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHGHI 82
Cdd:cd10554    1 FVIADPDKCIGCRTCEVACAAAHSGKGIFeAGTDGLPFLPRLRVVKTGEVTAPVQCRQCEDAPCANVCPVGAISQEDGVV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 485650817  83 FVEQTRCIGCKSCMLACPFGAMEVVSSRK---------KARAIKCDLCWHRETGPACVEACPTKALQCM 142
Cdd:cd10554   81 QVDEERCIGCKLCVLACPFGAIEMAPTTVpgvdwergpRAVAVKCDLCAGREGGPACVEACPTKALTLV 149
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
1-144 1.31e-58

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 178.70  E-value: 1.31e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVSHQenqdcaALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHG 80
Cdd:COG1142    1 MNKFIIADPEKCIGCRTCEAACAVAHE------GEEGEPFLPRIRVVRKAGVSAPVQCRHCEDAPCAEVCPVGAITRDDG 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCWHRETGPACVEACPTKALQCMDV 144
Cdd:COG1142   75 AVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAVAVKCDLCGGREGGPACVEACPTGALRLVDV 138
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 5-139 2.77e-15

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 70.71  E-value: 2.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817    5 IIADATKCIGCRTCEVACAVSHQENQDCAA-----------LSPDEFIsrirVIKDHSWTTA---------VACHQCEDA 64
Cdd:TIGR01582  24 KLIDVSSCIGCKACQAACQEWNDTTPPILSrkvggyqnppdLLPETFT----LMRFKEGEESdglewlirkDGCMHCREP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   65 PCANVCPVDA--ISREHGHIFVEQTRCIGCKSCMLACPFGAMEVvsSRKKARAIKCDLCWHRET---GPACVEACPTKAL 139
Cdd:TIGR01582 100 GCLKACPAPGaiIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRY--DKVDNRPYKCTLCIDRVSvgqEPACVKTCPTNAI 177
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 58-140 6.18e-12

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 58.41  E-value: 6.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   58 CHQCEDAPCANVCPVDAISR--EHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHR-ETG--PACVE 132
Cdd:pfam13247  10 CRHCLNPPCKASCPVGAIYKdeETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAE--KCDMCYDRvEAGllPACVQ 87


                  ....*...
gi 485650817  133 ACPTKALQ 140
Cdd:pfam13247  88 TCPTGAMN 95
 
Name Accession Description Interval E-value
PRK10330 PRK10330
electron transport protein HydN;
1-148 3.68e-64

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 194.34  E-value: 3.68e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVSHQENQDCAALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHG 80
Cdd:PRK10330   1 MNRFIIADASKCIGCRTCEVACVVSHQENQDCASLTPETFLPRIHVIKGVNVSTATVCRQCEDAPCANVCPNGAISRDKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVS-------------SRKKARAIKCDLCWHRETGPACVEACPTKALQCMDVEKV 147
Cdd:PRK10330  81 FVHVMQERCIGCKTCVVACPYGAMEVVVrpvirnsgaglnvRAEKAEANKCDLCNHREDGPACMAACPTHALICVDRNKL 160


                 .
gi 485650817 148 Q 148
Cdd:PRK10330 161 E 161
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 4-142 5.11e-61

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 185.16  E-value: 5.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   4 FIIADATKCIGCRTCEVACAVSHQENQDC-AALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHGHI 82
Cdd:cd10554    1 FVIADPDKCIGCRTCEVACAAAHSGKGIFeAGTDGLPFLPRLRVVKTGEVTAPVQCRQCEDAPCANVCPVGAISQEDGVV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 485650817  83 FVEQTRCIGCKSCMLACPFGAMEVVSSRK---------KARAIKCDLCWHRETGPACVEACPTKALQCM 142
Cdd:cd10554   81 QVDEERCIGCKLCVLACPFGAIEMAPTTVpgvdwergpRAVAVKCDLCAGREGGPACVEACPTKALTLV 149
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
1-144 1.31e-58

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 178.70  E-value: 1.31e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVSHQenqdcaALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHG 80
Cdd:COG1142    1 MNKFIIADPEKCIGCRTCEAACAVAHE------GEEGEPFLPRIRVVRKAGVSAPVQCRHCEDAPCAEVCPVGAITRDDG 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCWHRETGPACVEACPTKALQCMDV 144
Cdd:COG1142   75 AVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAVAVKCDLCGGREGGPACVEACPTGALRLVDV 138
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 1-155 1.24e-57

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 189.96  E-value: 1.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVSHQENQdcAALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHG 80
Cdd:PRK12769   1 MNRFIMANSQQCLGCHACEIACVMAHNDEQ--HVLSQHHFHPRITVIKHQQQRSAVTCHHCEDAPCARSCPNGAISHVDD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVV-----SSRKKARAIKCDLCWHRETGPACVEACPTKALQCMDVEKVQRHRLRQQ 155
Cdd:PRK12769  79 SIQVNQQKCIGCKSCVVACPFGTMQIVltpvaAGKVKATAHKCDLCAGRENGPACVENCPADALQLVTEQALSGMAKSRR 158
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 1-155 3.00e-44

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 153.64  E-value: 3.00e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVSHqeNQDCAALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISREHG 80
Cdd:PRK12809   1 MNKFIAAEAAECIGCHACEIACAVAH--NQENWPLSHSDFRPRIHVVGKGQAANPVACHHCNNAPCVTACPVNALTFQSD 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSrkkaRAIKCDLCWHRETGP-ACVEACPTKALQCMDVEKVQRHRLRQQ 155
Cdd:PRK12809  79 SVQLDEQKCIGCKRCAIACPFGVVEMVDT----IAQKCDLCNQRSSGTqACIEVCPTQALRLMDDKGLQQIKVARQ 150
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 5-145 1.03e-38

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 129.68  E-value: 1.03e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHQenqdcaaLSPDEFISRIRVIKDHSWT------TAVACHQCEDAPCANVCPVDAIS-R 77
Cdd:COG0437    8 MVIDLTKCIGCRACVVACKEENN-------LPVGVTWRRVRRYEEGEFPnvewlfVPVLCNHCDDPPCVKVCPTGATYkR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485650817  78 EHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHR-ETG--PACVEACPTKALQCMDVE 145
Cdd:COG0437   81 EDGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVE--KCTFCADRlDEGllPACVEACPTGALVFGDLD 149
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 5-140 1.76e-36

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 122.30  E-value: 1.76e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHqenqdCAALSPdeFISRIRVIKDHSW--TTAVACHQCEDAPCANVCPVDAISR--EHG 80
Cdd:cd10550    1 LVVDPEKCTGCRTCELACSLKH-----EGVFNP--SLSRIRVVRFEPEglDVPVVCRQCEDAPCVEACPVGAISRdeETG 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKarAIKCDLCwhrETGPACVEACPTKALQ 140
Cdd:cd10550   74 AVVVDEDKCIGCGMCVEACPFGAIRVDPETGK--AIKCDLC---GGDPACVKVCPTGALE 128
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 5-147 7.38e-35

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 118.53  E-value: 7.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHqenqdcaalSPdefISRIRVIK-DHSWTTAVACHQCEDAPCANVCPVDAISREH-GHI 82
Cdd:cd16374    1 VYVDPERCIGCRACEIACAREH---------SG---KPRISVEVvEDLASVPVRCRHCEDAPCMEVCPTGAIYRDEdGAV 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  83 FVEQTRCIGCKSCMLACPFGAMEVVSSRKKarAIKCDLCWHRETG---PACVEACPTKALQCMDVEKV 147
Cdd:cd16374   69 LVDPDKCIGCGMCAMACPFGVPRFDPSLKV--AVKCDLCIDRRREgklPACVEACPTGALKFGDIEEL 134
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 5-141 9.57e-35

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 118.13  E-value: 9.57e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHQENQD--CAALSPDEFISRIRVIKDHSWTTAVACHQCEDAPCANVCPVDAISR--EHG 80
Cdd:cd10563    2 IFIDEEKCLGCKLCEVACAVAHSKSKDliKAKLEKERPRPRIRVEESGGRSFPLQCRHCDEPPCVKACMSGAMHKdpETG 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAmeVVSSRKKARAIKCDLCWHRETgPACVEACPTKALQC 141
Cdd:cd10563   82 IVIHDEEKCVGCWMCVMVCPYGA--IRPDKERKVALKCDLCPDRET-PACVEACPTGALVL 139
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 5-140 2.11e-34

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 117.10  E-value: 2.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHQenqdcaaLSPDEFISRIRVIKDHS---WTTAVACHQCEDAPCANVCPVDAISR-EHG 80
Cdd:cd04410    1 LVVDLDRCIGCGTCEVACKQEHG-------LRPGPDWSRIKVIEGGGlerAFLPVSCMHCEDPPCVKACPTGAIYKdEDG 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHRET---GPACVEACPTKALQ 140
Cdd:cd04410   74 IVLIDEDKCIGCGSCVEACPYGAIVFDPEPGKAV--KCDLCGDRLDeglEPACVKACPTGALT 134
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 8-140 3.07e-34

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 116.89  E-value: 3.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVACAVSHQenqdcaaLSPDEFISRIRVIKDHSWTTA------VACHQCEDAPCANVCPVDAIS-REHG 80
Cdd:cd16371    5 DQERCIGCKACEIACKDKND-------LPPGVNWRRVYEYEGGEFPEVfayflsMSCNHCENPACVKVCPTGAITkREDG 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHRETG---PACVEACPTKALQ 140
Cdd:cd16371   78 IVVVDQDKCIGCGYCVWACPYGAPQYNPETGKMD--KCDMCVDRLDEgekPACVAACPTRALD 138
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 8-139 2.70e-30

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 108.00  E-value: 2.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVACavsHQENQdcaaLSPDEFisRIRVIKDHSWTTA--------VACHQCEDAPCANVCPVDAIS-RE 78
Cdd:cd10551    4 DLRKCIGCGACVVAC---KAENN----VPPGVF--RNRVLEYEVGEYPnvkrtflpVLCNHCENPPCVKVCPTGATYkRE 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485650817  79 HGHIFVEQTRCIGCKSCMLACPFGA----------MEVVSSRKKARAIKCDLCWHR-ETG--PACVEACPTKAL 139
Cdd:cd10551   75 DGIVLVDYDKCIGCRYCMAACPYGAryfnpeepheFGEVPVRPKGVVEKCTFCYHRlDEGllPACVEACPTGAR 148
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 8-153 1.83e-27

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 102.08  E-value: 1.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVAC-----------AVSHQENQDCAALSPD-----EFISRIRVIKDHSWTTAV-------ACHQCEDA 64
Cdd:cd10560    5 DTSICIGCKACEVACkqwnqlpadgyDFSGMSYDNTGDLSAStwrhvKFIERPTEDGPANEGGDLqwlfmsdVCKHCTDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  65 PCANVCPVDAISR-EHGHIFVEQTRCIGCKSCMLACPFGAMEVvsSRKKARAIKCDLCWHRET---GPACVEACPTKALQ 140
Cdd:cd10560   85 GCLEACPTGAIFRtEFGTVYIQPDICNGCGYCVAACPFGVIDR--NEETGRAHKCTLCYDRLKdglEPACAKACPTGSIQ 162

                        170
                 ....*....|....
gi 485650817 141 CMDVEK-VQRHRLR 153
Cdd:cd10560  163 FGPLEElRERARAR 176
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 8-140 1.12e-25

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 96.51  E-value: 1.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVACAVSH----------QENQDCAALSPDEFIsrirVIKDH-------SWTTA-VACHQCEDAPCANV 69
Cdd:cd10561    5 DTTRCIGCRACEVACKEWNglpaedtafgPGWDNPRDLSAKTYT----VIKRYevetggkGFVFVkRQCMHCLDPACVSA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485650817  70 CPVDAISR-EHGHIFVEQTRCIGCKSCMLACPFG--AMEVVSSRKKARaiKCDLCWHRE---TGPACVEACPTKALQ 140
Cdd:cd10561   81 CPVGALRKtPEGPVTYDEDKCIGCRYCMVACPFNipKYEWDSANPKIR--KCTMCYDRLkegKQPACVEACPTGALL 155
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 8-157 4.93e-24

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 91.68  E-value: 4.93e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVACavSHQENQDCAALSPDEFISRIRVIKdhswTTAVACHQCEDAPCANVCPVDAISR-EHGHIFVEQ 86
Cdd:cd16369    7 DPSRCIGCRACVAAC--RECGTHRGKSMIHVDYIDRGESTQ----TAPTVCMHCEDPTCAEVCPADAIKVtEDGVVQSAL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485650817  87 T-RCIGCKSCMLACPFGAMEVVSSRKKarAIKCDLCWHRET---GPACVEACPTKALQCMDVEKVQRHRLRQQPV 157
Cdd:cd16369   81 KpRCIGCSNCVNACPFGVPKYDEERNL--MMKCDMCYDRTSvgkAPMCASVCPSGALFYGTREEIQALRPGSTPV 153
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 8-140 5.99e-24

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 90.92  E-value: 5.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVACAVSHQENQDCAAL-----SPDEF------ISRIRVIK----DHSWTTA-VACHQCEDAPCANVCP 71
Cdd:cd16366    4 DTSRCTGCRACQVACKQWNGLPAEKTEFtgsyqNPPDLtahtwtLVRFYEVEkpggDLSWLFRkDQCMHCTDAGCLAACP 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485650817  72 VDAISR-EHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHRETG---PACVEACPTKALQ 140
Cdd:cd16366   84 TGAIIRtETGTVVVDPETCIGCGYCVNACPFDIPRFDEETGRVA--KCTLCYDRISNglqPACVKTCPTGALT 154
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 2-145 5.05e-23

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 88.13  E-value: 5.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   2 NRFIIADATKCIGCRTCEVACAVSHQENqdcaalspdefiSRI--RVIKDHSWTTAVACHQCEDAPCANVCPVDAISR-E 78
Cdd:cd16367   11 TNLLVIDLDRCIRCDNCEKACADTHDGH------------SRLdrNGLRFGNLLVPTACRHCVDPVCMIGCPTGAIHRdD 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485650817  79 HGHIFVEQtRCIGCKSCMLACPFGAMEVVssrkkaRAIKCDLCwHRETGPACVEACPTKALQCMDVE 145
Cdd:cd16367   79 GGEVVISD-ACCGCGNCASACPYGAIQMV------RAVKCDLC-AGYAGPACVSACPTGAAIRVNPE 137
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 8-140 5.97e-22

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 85.82  E-value: 5.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVACAVSHQEN----------QDCAALSPD-----EFISRIRVIKDHSWTTAV-ACHQCEDAPCANVCP 71
Cdd:cd10562    4 DTSKCTACRGCQVACKQWNQLPaektpftgsyQNPPDLTPNtwtliRFYEHEEDNGGIRWLFRKrQCMHCTDAACVKVCP 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485650817  72 VDAISR-EHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHR-ETG--PACVEACPTKALQ 140
Cdd:cd10562   84 TGALYKtENGAVVVDEDKCIGCGYCVAACPFDVPRYDETTNKIT--KCTLCFDRiENGmqPACVKTCPTGALT 154
PRK09898 PRK09898
ferredoxin-like protein;
5-147 1.04e-21

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 86.81  E-value: 1.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHQenqdcAALSPdeFISRIRVIKDHSW----------------TTAVACHQCEDAPCAN 68
Cdd:PRK09898  61 LVTQRARCTGCHRCEISCTNFND-----GSVGT--FFSRIKIHRNYFFgdngvgsggglygdlnYTADTCRQCKEPQCMN 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  69 VCPVDAIS--REHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCwhretgPACVEACPTKALQCMDVEK 146
Cdd:PRK09898 134 VCPIGAITwqQKEGCITVDHKRCIGCSACTTACPWMMATVNTESKKSS--KCVLC------GECANACPTGALKIIEWKD 205


                 .
gi 485650817 147 V 147
Cdd:PRK09898 206 I 206
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 5-140 1.12e-21

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 86.67  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVAC--------AVSHQEN--QDCAALSPDEF-ISRIRVIKDH---SW-TTAVACHQCEDAPCANV 69
Cdd:cd10558    2 KLIDVSKCIGCKACQVACkewndlraEVGHNVGtyQNPADLSPETWtLMKFREVEDNgklEWlIRKDGCMHCADPGCLKA 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485650817  70 CPVDAISREHGHIFV--EQTRCIGCKSCMLACPFGAMEvvSSRKKARAIKCDLCWHRET---GPACVEACPTKALQ 140
Cdd:cd10558   82 CPSPGAIVQYANGIVdfQSDKCIGCGYCIKGCPFDIPR--ISKDDNKMYKCTLCSDRVSvglEPACVKTCPTGALH 155
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 5-140 3.61e-21

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 83.57  E-value: 3.61e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACavsHQENQDCAALSPDEFISRIRVIKDHSWTTAVA---CHQCEDAPCANVCPVDAISR--EH 79
Cdd:cd10553    5 LYHDSKRCIGCLACEVHC---KVKNNLPVGPRLCRIFAVGPKMVGGKPRLKFVymsCFHCENPWCVKACPTGAMQKreKD 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485650817  80 GHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKarAIKCDLCWHR-ETG--PACVEACPTKALQ 140
Cdd:cd10553   82 GIVYVDQELCIGCKACIEACPWGIPQWNPATGK--VVKCDYCMDRiDQGlkPACVTGCTTHALS 143
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
5-134 4.27e-19

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 80.69  E-value: 4.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHQENQDcaalspdEFISRIR----VIKDHSWTTAVA----CHQCEDAPCANVCPVDA-I 75
Cdd:PRK14993  46 MLIDLRRCIGCQSCTVSCTIENQTPQG-------AFRTTVNqyqvQREGSQEVTNVLlprlCNHCDNPPCVPVCPVQAtF 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485650817  76 SREHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHR-ETG--PACVEAC 134
Cdd:PRK14993 119 QREDGIVVVDNKRCVGCAYCVQACPYDARFINHETQTAD--KCTFCVHRlEAGllPACVESC 178
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
8-138 1.80e-18

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 80.10  E-value: 1.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   8 DATKCIGCRTCEVAC--AVSHQENQDCAAL--SPDEFISRIR-VIKDHSWTTAVA--------------CHQCEDAPCAN 68
Cdd:PRK10882  43 DSTLCVGCQACVTKCqeINFPERNPQGEQTwdNPDKLSPYTNnIIKVWKSGTGVNkdqeengyayikkqCMHCVDPNCVS 122

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 485650817  69 VCPVDAISR--EHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCWHRET-------GPACVEACPTKA 138
Cdd:PRK10882 123 VCPVSALTKdpKTGIVHYDKDVCTGCRYCMVACPFNVPKYDYNNPFGAIHKCELCNQKGVerldkggLPGCVEVCPTGA 201
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 5-145 1.65e-16

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 72.36  E-value: 1.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHQENQ--DCAALSPDEFISRIRVIKDHSWT--------TAVACHQCEDAPCANVCPVDA 74
Cdd:cd10552    1 LVIDVAKCNGCYNCFLACKDEHVGNDwpGYAAPQPRHGHFWMRILRRERGQypkvdvayLPVPCNHCDNAPCIKAAKDGA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485650817  75 IS-REHGHIFVEQTRCIGCKSCMLACPFGAMEVvsSRKKARAIKCDLCWHR----ETGPACVEACPTKALQCMDVE 145
Cdd:cd10552   81 VYkRDDGIVIIDPEKAKGQKQLVDACPYGAIYW--NEELQVPQKCTFCAHLlddgWKEPRCVQACPTGALRFGKLE 154
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 5-139 2.77e-15

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 70.71  E-value: 2.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817    5 IIADATKCIGCRTCEVACAVSHQENQDCAA-----------LSPDEFIsrirVIKDHSWTTA---------VACHQCEDA 64
Cdd:TIGR01582  24 KLIDVSSCIGCKACQAACQEWNDTTPPILSrkvggyqnppdLLPETFT----LMRFKEGEESdglewlirkDGCMHCREP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   65 PCANVCPVDA--ISREHGHIFVEQTRCIGCKSCMLACPFGAMEVvsSRKKARAIKCDLCWHRET---GPACVEACPTKAL 139
Cdd:TIGR01582 100 GCLKACPAPGaiIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRY--DKVDNRPYKCTLCIDRVSvgqEPACVKTCPTNAI 177
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 3-139 1.54e-14

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 65.82  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   3 RFIIADATKCIGCRTCEVACAVSHQEnqdcaalSPDEFISRIRVIKDHSWTTAVACHQCedAPCANVCPVDAISRE-HGH 81
Cdd:cd16372    1 KLLVTDPEKCIGCLQCEEACSKTFFK-------EEDREKSCIRITETEGGYAINVCNQC--GECIDVCPTGAITRDaNGV 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  82 IFVEQTRCIGCKSCMLACPFGAMevVSSRKKARAIKCDLCwhretgPACVEACPTKAL 139
Cdd:cd16372   72 VMINKKLCVGCLMCVGFCPEGAM--FKHEDYPEPFKCIAC------GICVKACPTGAL 121
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
11-108 7.98e-14

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 67.36  E-value: 7.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  11 KCIGCRTCEVACAVSHQENQDCAALSPDEFISRIRVIKDhswttavACHQCEdaPCANVCPVDAISREHGHIFVEQTRCI 90
Cdd:COG4624   53 RCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKE-------KCKNCY--PCVRACPVKAIKVDDGKAEIDEEKCI 123

                         90
                 ....*....|....*...
gi 485650817  91 GCKSCMLACPFGAMEVVS 108
Cdd:COG4624  124 SCGQCVAVCPFGAITEKS 141
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 58-140 6.18e-12

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 58.41  E-value: 6.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   58 CHQCEDAPCANVCPVDAISR--EHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHR-ETG--PACVE 132
Cdd:pfam13247  10 CRHCLNPPCKASCPVGAIYKdeETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAE--KCDMCYDRvEAGllPACVQ 87


                  ....*...
gi 485650817  133 ACPTKALQ 140
Cdd:pfam13247  88 TCPTGAMN 95
W-FDH cd10559
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ...
 5-147 1.02e-09

tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319881 [Multi-domain]  Cd Length: 200  Bit Score: 54.75  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVSHQ------EN----QDCAALSPDEF-ISRIRVIKDHS----WT-TAVACHQCEDAPCAN 68
Cdd:cd10559    2 FLIDTTRCTACRGCQVACKQWNQlpaeqtKNtgshQNPPDLSANTYkLVRFNEVRNENgkpdWLfFPDQCRHCVTPPCKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  69 VCPVDAISREHGH-----IFVEQTRCIGCKSCMLACPFGAMEVVSsrKKARAIKCDLCWHRETG---PACVEACPTKALQ 140
Cdd:cd10559   82 AADMVPGAVIQDEatgavVFTEKTAELDFDDVLSACPYNIPRKNE--ATGRIVKCDMCIDRVSNglqPACVKACPTGAMN 159


                 ....*..
gi 485650817 141 CMDVEKV 147
Cdd:cd10559  160 FGDRDEM 166
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 3-139 1.86e-09

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 52.66  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   3 RFIIADATKCIGCRTCEVACAVSHQENqdcaaLSPDEFISRIRVIKD-HSWTTAVACHQCEDAPCANVCPVDAIS-REHG 80
Cdd:cd16370    2 RLRVKDMERCIGCYSCMLACSRRVHKS-----ASLSKSAIRVRTRGGlEGGFTVVVCRACEDPPCAEACPTGALEpRKGG 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKarAIKCDLCwhretgPACVEACPTKAL 139
Cdd:cd16370   77 GVVLDKEKCIGCGNCVKACIVGAIFWDEETNK--PIICIHC------GYCARYCPHDVL 127
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 58-138 3.94e-09

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 53.19  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  58 CHQCEDAPCANVCPVDAI-SREHGHIFVEQTRCIGCKSCMLACPFGamevVSSRKKARAI---------------KCDLC 121
Cdd:cd16368   91 CMHCDNPPCAKLCPFGAArKTPEGAVYIDDDLCFGGAKCRDVCPWH----IPQRQAGVGIylhlapeyagggvmyKCDLC 166

                         90       100
                 ....*....|....*....|
gi 485650817 122 WHR-ETG--PACVEACPTKA 138
Cdd:cd16368  167 KDLlAQGkpPACIEACPKGA 186
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
58-140 6.78e-08

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 50.41  E-value: 6.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  58 CHQCEDAPCANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCwhretGpACVEACPTK 137
Cdd:COG4624   62 CRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKAEIDEEKCISC-----G-QCVAVCPFG 135


                 ...
gi 485650817 138 ALQ 140
Cdd:COG4624  136 AIT 138
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
66-106 7.38e-08

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 47.03  E-value: 7.38e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 485650817  66 CANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEV 106
Cdd:COG2768   19 CVKVCPVGAISIEDGKAVIDPEKCIGCGACIEVCPVGAIKI 59
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 58-107 3.88e-07

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 45.03  E-value: 3.88e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 485650817  58 CHQCEDapCANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:COG4231   24 CTGCGA--CVKVCPADAIEEGDGKAVIDPDLCIGCGSCVQVCPVDAIKLE 71
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 5-139 5.90e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 45.85  E-value: 5.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   5 IIADATKCIGCRTCEVACAVshqenqDCAALSPDEFISRIRVIKDHSwttAVACHQCedapcANVCPVDAISR------- 77
Cdd:cd10549    1 LKYDPEKCIGCGICVKACPT------DAIELGPNGAIARGPEIDEDK---CVFCGAC-----VEVCPTGAIELtpegkey 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485650817  78 --EHGHIFVEQTRCIGCKSCMLACPFGAMEVVssRKKARAI---KCDLCwhretgPACVEACPTKAL 139
Cdd:cd10549   67 vpKEKEAEIDEEKCIGCGLCVKVCPVDAITLE--DELEIVIdkeKCIGC------GICAEVCPVNAI 125
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 6-135 9.38e-07

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 46.91  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   6 IADATKCIGCRTCEVACA----------------VSHQ--------------------ENQDCAALSPDEF--------- 40
Cdd:cd10555    8 VMDLNKCIGCQTCTVACKtlwtnrngreymywnnVETQpgkgypknwekkgggfkdkgELKPGIIPTLEDYgvpweynhe 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  41 ---------ISRIRVIKDHSWTT-------------------AVACHQCEDAPCANVCPVDAI-SREH-GHIFVEQTRCI 90
Cdd:cd10555   88 eelfegkggRVRPSPKGDPTWGPnwdedqgageypnsyyfylPRICNHCTNPACLAACPRKAIyKREEdGIVLVDQDRCR 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 485650817  91 GCKSCMLACPFGAMEVVSSRKKARaiKCDLCWHR-ETG--PACVEACP 135
Cdd:cd10555  168 GYRYCVEACPYKKIYFNPVEQKSE--KCIFCYPRiEKGvaPACARQCV 213
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 66-111 1.01e-06

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 43.89  E-value: 1.01e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 485650817  66 CANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRK 111
Cdd:COG2221   23 CVAVCPTGAISLDDGKLVIDEEKCIGCGACIRVCPTGAIKGEKPKK 68
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
58-106 1.07e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 47.16  E-value: 1.07e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 485650817  58 CHQCEdaPCANVCPVDAIS-REHGHIFVEQTRCIGCKSCMLACPFGAMEV 106
Cdd:COG1148  498 CTGCG--RCVEVCPYGAISiDEKGVAEVNPALCKGCGTCAAACPSGAISL 545
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
41-114 3.72e-06

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 45.05  E-value: 3.72e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485650817  41 ISRIRVIKDHSwttavACHQCEDapCANVCPVDAISRehgHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKAR 114
Cdd:COG0348  200 LSTLRVRYDRG-----DCIDCGL--CVKVCPMGIDIR---KGEINQSECINCGRCIDACPKDAIRFSSRGEKTR 263
PRK13795 PRK13795
hypothetical protein; Provisional
 66-100 4.66e-06

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 45.37  E-value: 4.66e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 485650817  66 CANVCPVDAISREHG--HIFVEQTRCIGCKSCMLACP 100
Cdd:PRK13795 589 CVGACPTGAIRIEEGkrKISVDEEKCIHCGKCTEVCP 625
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
84-140 5.26e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 44.85  E-value: 5.26e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  84 VEQTRCIGCKSCMLACPFGAMEVVSSRK-KARAIKCDLCwhretGpACVEACPTKALQ 140
Cdd:COG1148  493 VDPEKCTGCGRCVEVCPYGAISIDEKGVaEVNPALCKGC-----G-TCAAACPSGAIS 544
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
88-140 7.94e-06

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 43.33  E-value: 7.94e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485650817  88 RCIGCKSCMLACPFGAMEVVSSRKK-------------ARAIKCDLcwhretgpaCVEACPTKALQ 140
Cdd:PRK05888  59 RCIACKLCAAICPADAITIEAAEREdgrrrttrydinfGRCIFCGF---------CEEACPTDAIV 115
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 76-140 1.03e-05

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 42.40  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   76 SREHGHIFVEQT-----RCIGCKSCMLACPFGAMEVVSSRKK-------------ARAIKCDLcwhretgpaCVEACPTK 137
Cdd:TIGR01971  27 PRFRGRIVLTRDpngeeKCIGCTLCAAVCPADAIRVVPAEGEdgkrrlkfyeinfGRCIFCGL---------CEEACPTD 97


                  ...
gi 485650817  138 ALQ 140
Cdd:TIGR01971  98 AIV 100
flavo_MJ0208 TIGR02700
archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of ...
 58-104 1.05e-05

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]


Pssm-ID: 131747 [Multi-domain]  Cd Length: 234  Bit Score: 43.71  E-value: 1.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 485650817   58 CHQCEDapCANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAM 104
Cdd:TIGR02700 150 CKGCGI--CVDACPRSAIDMVDGKAFIRLLKCVGCGKCKEACPYNAI 194
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 1-107 1.38e-05

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 42.38  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817   1 MNRFIIADATKCIGCRTCEVACAVshqenqdcAALSPDEFISRIRVIKDHSWTTAVACHQCEDapCANVCPVDAISREHG 80
Cdd:cd10549   31 IARGPEIDEDKCVFCGACVEVCPT--------GAIELTPEGKEYVPKEKEAEIDEEKCIGCGL--CVKVCPVDAITLEDE 100

                         90       100
                 ....*....|....*....|....*...
gi 485650817  81 HIFVE-QTRCIGCKSCMLACPFGAMEVV 107
Cdd:cd10549  101 LEIVIdKEKCIGCGICAEVCPVNAIKLV 128
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 88-150 1.78e-05

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 42.00  E-value: 1.78e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  88 RCIGCKSCMLACPFGAMEVVSSRKKARAI-----KCDLCwhretgPACVEACPTKALQCMDVEKVQRH 150
Cdd:cd10549    7 KCIGCGICVKACPTDAIELGPNGAIARGPeidedKCVFC------GACVEVCPTGAIELTPEGKEYVP 68
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 66-107 1.88e-05

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 40.48  E-value: 1.88e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 485650817  66 CANVCPVDAIS-REHGHIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:COG1149   19 CVEVCPEGAIKlDDGGAPVVDPDLCTGCGACVGVCPTGAITLE 61
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 80-139 2.04e-05

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 40.46  E-value: 2.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  80 GHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCWHREtgpACVEACPTKAL 139
Cdd:COG1146    1 MMPVIDTDKCIGCGACVEVCPVDVLELDEEGKKALVINPEECIGCG---ACELVCPVGAI 57
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 71-140 3.92e-05

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 40.97  E-value: 3.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485650817  71 PVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKAR--AIKCDLCwhretgPACVEACPTKALQ 140
Cdd:PRK08348  26 PVPVPEDFRGKILYDVDKCVGCRMCVTVCPAGVFVYLPEIRKVAlwTGRCVFC------GQCVDVCPTGALQ 91
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 81-140 1.15e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 38.56  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKA-RAIKCDLCwhretgPACVEACPTKALQ 140
Cdd:COG1149    5 IPVIDEEKCIGCGLCVEVCPEGAIKLDDGGAPVvDPDLCTGC------GACVGVCPTGAIT 59
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
8-73 1.32e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 40.70  E-value: 1.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485650817   8 DATKCIGCRTCEVACA-VSHQenqdCAALSPDEfISRIRVIKDHswttAVACHQcedapCANVCPVD 73
Cdd:PRK08318 340 DQDKCIGCGRCYIACEdTSHQ----AIEWDEDG-TRTPEVIEEE----CVGCNL-----CAHVCPVE 392
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
66-138 1.36e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 40.69  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  66 CANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAikcdLCWHRETGPA--------------CV 131
Cdd:PRK07118 147 CVAACPFDAIHIENGLPVVDEDKCTGCGACVKACPRNVIELIPKSARVFV----ACNSKDKGKAvkkvcevgcigcgkCV 222


                 ....*..
gi 485650817 132 EACPTKA 138
Cdd:PRK07118 223 KACPAGA 229
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
89-142 2.21e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 39.92  E-value: 2.21e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 485650817  89 CIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCwhretgPACVEACPTKALQCM 142
Cdd:PRK07118 215 CIGCGKCVKACPAGAITMENNLAVIDQEKCTSC------GKCVEKCPTKAIRIL 262
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 88-151 2.66e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 37.42  E-value: 2.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  88 RCIGCKSCMLACPFGAMEVVSSRKKARAI----KCDLCWhretgpACVEACPTKALQCMDVEKVQRHR 151
Cdd:COG1143    3 KCIGCGLCVRVCPVDAITIEDGEPGKVYVidpdKCIGCG------LCVEVCPTGAISMTPFELAVEDR 64
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 58-106 3.85e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 37.03  E-value: 3.85e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 485650817  58 CHQCEDapCANVCPVDAIS----REHGHIFVEQTRCIGCKSCMLACPFGAMEV 106
Cdd:COG1143    4 CIGCGL--CVRVCPVDAITiedgEPGKVYVIDPDKCIGCGLCVEVCPTGAISM 54
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
77-140 5.21e-04

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 36.63  E-value: 5.21e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485650817  77 REHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCwhretgPACVEACPTKALQ 140
Cdd:COG2768    1 HSLGKPYVDEEKCIGCGACVKVCPVGAISIEDGKAVIDPEKCIGC------GACIEVCPVGAIK 58
FixX COG2440
Ferredoxin-like protein FixX [Energy production and conversion];
46-103 8.91e-04

Ferredoxin-like protein FixX [Energy production and conversion];


Pssm-ID: 441981 [Multi-domain]  Cd Length: 87  Bit Score: 36.33  E-value: 8.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 485650817  46 VIKDHSwttaVACHQCEDAPCANVCPVDAIS-REHGHIFVEQTRCIGCKSCMLACPFGA 103
Cdd:COG2440   16 KVKDPD----ICIARCLAKPCTRYCPAGVYEiVGDGRLQINYENCLECGTCRIKCPTQN 70
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
66-140 9.12e-04

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 38.12  E-value: 9.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  66 CANVCPVDAI----SREHG-HIFVEQTRCIGCKSCMLACPfgaMEVVSSRKKARAIKCDLCWhretgpACVEACPTKALQ 140
Cdd:COG0348  184 CRYLCPYGAFqgllSDLSTlRVRYDRGDCIDCGLCVKVCP---MGIDIRKGEINQSECINCG------RCIDACPKDAIR 254
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
 56-101 1.01e-03

quinol dehydrogenase periplasmic component; Provisional


Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 38.07  E-value: 1.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  56 VACHQCEDAPCANVCPVDAISREHGHI---------FVEQTRCIG-----CKSCMLACPF 101
Cdd:PRK09476  97 IPCEMCEDIPCVKACPSGALDRELVDIddarmglavLVDQENCLNfqglrCDVCYRVCPL 156
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 58-107 1.04e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.84  E-value: 1.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 485650817  58 CHQCEDapCANVCPVDAISREHG---HIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:COG1146   10 CIGCGA--CVEVCPVDVLELDEEgkkALVINPEECIGCGACELVCPVGAITVE 60
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 58-107 1.18e-03

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 36.18  E-value: 1.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 485650817  58 CHQCedAPCANVCPVDAIS-REHGHIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:COG1144   32 CIGC--GLCWIVCPDGAIRvDDGKYYGIDYDYCKGCGICAEVCPVKAIEMV 80
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 66-107 1.27e-03

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 37.84  E-value: 1.27e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 485650817  66 CANVCPV-----DAI--SREHGHIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:COG1245   21 CIKYCPVnrtgkEAIeiDEDDGKPVISEELCIGCGICVKKCPFDAISIV 69
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 88-140 1.40e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.87  E-value: 1.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485650817  88 RCIGCKSCMLACPFGAMEVVSSRKKARAIK----------CDLCwHRETGPACVEACPTKALQ 140
Cdd:cd16370   10 RCIGCYSCMLACSRRVHKSASLSKSAIRVRtrggleggftVVVC-RACEDPPCAEACPTGALE 71
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 82-140 1.51e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 36.98  E-value: 1.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485650817  82 IFVEQTRCIGCKSCMLACPfgamEVVSSRKKAR------------AIKCDLCWHRETgPACVEACPTKALQ 140
Cdd:cd16369    4 FFIDPSRCIGCRACVAACR----ECGTHRGKSMihvdyidrgestQTAPTVCMHCED-PTCAEVCPADAIK 69
NapF COG1145
Ferredoxin [Energy production and conversion];
66-107 1.68e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 37.39  E-value: 1.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 485650817  66 CANVCPVDAISREHG--HIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:COG1145  190 CVKVCPTGAIRLKDGkpQIVVDPDKCIGCGACVKVCPVGAISLE 233
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
66-107 1.83e-03

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 37.48  E-value: 1.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 485650817  66 CANVCPV-----DAI--SREHGHIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:PRK13409  21 CIKYCPVvrtgeETIeiDEDDGKPVISEELCIGCGICVKKCPFDAISIV 69
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 58-107 1.94e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 37.55  E-value: 1.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 485650817  58 CHQC-EDAPCANVCPVDAISR--EHGHIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:PRK12771 509 CGNCfECDNCYGACPQDAIIKlgPGRRYHFDYDKCTGCHICADVCPCGAIEMG 561
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 82-139 2.63e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 34.64  E-value: 2.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  82 IFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAIKCDLCWHretgpaCVEACPTKAL 139
Cdd:COG2221   10 PKIDEEKCIGCGLCVAVCPTGAISLDDGKLVIDEEKCIGCGA------CIRVCPTGAI 61
PRK13795 PRK13795
hypothetical protein; Provisional
 88-135 2.80e-03

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 36.90  E-value: 2.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 485650817  88 RCIGCKSCMLACPFGAMEVVSSRKKARAI--KCDLCwhretgPACVEACP 135
Cdd:PRK13795 582 ECVGCGVCVGACPTGAIRIEEGKRKISVDeeKCIHC------GKCTEVCP 625
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 83-139 3.14e-03

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 36.59  E-value: 3.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 485650817  83 FVEQTRCIGCKSCMLACPFGAmevVSSRKKARAIKCDLCwhrETGPACVEACPTKAL 139
Cdd:cd03110   60 FIDQEKCIRCGNCERVCKFGA---ILEFFQKLIVDESLC---EGCGACVIICPRGAI 110
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
56-103 4.40e-03

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 35.63  E-value: 4.40e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  56 VACHQCEdapcaNVCPVDAIS-----REHGHIFVEQ-----TRCIGCKSCMLACPFGA 103
Cdd:PRK05888  61 IACKLCA-----AICPADAITieaaeREDGRRRTTRydinfGRCIFCGFCEEACPTDA 113
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 66-107 4.71e-03

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 36.21  E-value: 4.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 485650817  66 CANVCPVDAISREHGHIFVEQTRCIGCKSCMLACPFGAMEVV 107
Cdd:cd03110   72 CERVCKFGAILEFFQKLIVDESLCEGCGACVIICPRGAIYLK 113
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 84-140 4.81e-03

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 36.13  E-value: 4.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485650817  84 VEQTRCIGCKSCMLACPFGAM-----EVVSSRKKA---RAIKCDLCWHRETGpACVEACPTKALQ 140
Cdd:PRK14028 244 IDHSKCIMCRKCWLYCPDDAIieawrEAEGPRGRKfrmKMIDFDYQYCKGCG-VCAEVCPTGAIQ 307
NapF COG1145
Ferredoxin [Energy production and conversion];
75-140 5.05e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 36.24  E-value: 5.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  75 ISREHGHIFVEQTRCIGCKSCMLACPFGAMEVVSSRKKARAI--KCDLCwhretgPACVEACPTKALQ 140
Cdd:COG1145  170 IAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKPQIVVDpdKCIGC------GACVKVCPVGAIS 231
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 81-138 5.66e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 33.86  E-value: 5.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 485650817  81 HIFVEQTRCIGCKSCMLACPFGAMEVVssrKKARAIKCDLCWHREtgpACVEACPTKA 138
Cdd:COG4231   16 RYVIDEDKCTGCGACVKVCPADAIEEG---DGKAVIDPDLCIGCG---SCVQVCPVDA 67
RNAP_D cd07030
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ...
 39-107 6.22e-03

D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer.


Pssm-ID: 132908 [Multi-domain]  Cd Length: 259  Bit Score: 35.71  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  39 EFISRIRVIKDHS-WTTAVAC------------HQCEDAPCANVCPVDAISREHGHIFVE-QTRCIGCKSCMLACPFGAM 104
Cdd:cd07030  137 EAYARLGRGKEHAkWQPTTACgykyypvieideDCDGCGKCVEECPRGVLELEEGKVVVEdLEDCSLCKLCERACDAGAI 216


                 ...
gi 485650817 105 EVV 107
Cdd:cd07030  217 RVG 219
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 83-148 6.42e-03

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 35.31  E-value: 6.42e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485650817  83 FVEQTRCIGCKSCMLACPFGAmeVVSSRKKARAIKCDLCwhreTG-PACVEACPTkalQCMDVEKVQ 148
Cdd:PRK05113 110 FIDEDNCIGCTKCIQACPVDA--IVGATKAMHTVISDLC----TGcDLCVAPCPT---DCIEMIPVA 167
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 81-140 7.78e-03

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 34.65  E-value: 7.78e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485650817  81 HIFVEQTRCIGCKSCMLAC------PFGAM--EVVSSRKKARAIKCDL------CWHRETgPACVEACPTKALQ 140
Cdd:cd10553    4 YLYHDSKRCIGCLACEVHCkvknnlPVGPRlcRIFAVGPKMVGGKPRLkfvymsCFHCEN-PWCVKACPTGAMQ 76
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 84-139 8.79e-03

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 33.49  E-value: 8.79e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 485650817  84 VEQTRCIGCKSCMLACPFGAMEVVSSRKKA-RAIKCDLCWhretgpACVEACPTKAL 139
Cdd:COG1144   27 VDEDKCIGCGLCWIVCPDGAIRVDDGKYYGiDYDYCKGCG------ICAEVCPVKAI 77
PRK06991 PRK06991
electron transport complex subunit RsxB;
70-151 9.58e-03

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 35.16  E-value: 9.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485650817  70 CPVDAISREHGH------IFVEQTRCIGCKSCMLACPFGAmeVVSSRKKARAIKCDLCwhreTG-PACVEACPtkaLQCM 142
Cdd:PRK06991  62 KPVIPLDPANGVerpravAVIDEQLCIGCTLCMQACPVDA--IVGAPKQMHTVLADLC----TGcDLCVPPCP---VDCI 132


                 ....*....
gi 485650817 143 DVEKVQRHR 151
Cdd:PRK06991 133 DMVPVTGER 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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