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Conserved domains on  [gi|485652537|ref|WP_001297917|]
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MULTISPECIES: colibactin biosynthesis aminomalonyl-acyl carrier protein ClbE [Enterobacterales]

Protein Classification

acyl carrier protein( domain architecture ID 516)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

Gene Ontology:  GO:0006633
PubMed:  30543875

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP-binding super family cl09936
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-78 1.81e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


The actual alignment was detected with superfamily member PRK07081:

Pssm-ID: 447865  Cd Length: 83  Bit Score: 44.18  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485652537  6 MKAAIREFLSRSLR----GHTLNDDDDIFSLGLVhSLFTVQIILFIEKNFQVELEVSELKTEQIATVNKI---VELIQRQ 78
Cdd:PRK07081  1 MKNTIRTILKKVAKlevpIDSIADDADLYEAGLS-SLATVQLMLAIEDAFDIEIPDEMLNRKLFASIDALagaVTQLQDA 79
 
Name Accession Description Interval E-value
PRK07081 PRK07081
acyl carrier protein; Provisional
 6-78 1.81e-07

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 44.18  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485652537  6 MKAAIREFLSRSLR----GHTLNDDDDIFSLGLVhSLFTVQIILFIEKNFQVELEVSELKTEQIATVNKI---VELIQRQ 78
Cdd:PRK07081  1 MKNTIRTILKKVAKlevpIDSIADDADLYEAGLS-SLATVQLMLAIEDAFDIEIPDEMLNRKLFASIDALagaVTQLQDA 79
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-80 9.04e-07

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 42.15  E-value: 9.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485652537  1 MKKQDMKAAIREFLSRSLR--GHTLNDDDDIFS-LGLvHSLFTVQIILFIEKNFQVELEVSELktEQIATVNKIVELIQR 77
Cdd:COG0236   1 MPREELEERLAEIIAEVLGvdPEEITPDDSFFEdLGL-DSLDAVELIAALEEEFGIELPDTEL--FEYPTVADLADYLEE 77


                ...
gi 485652537 78 QTG 80
Cdd:COG0236  78 KLA 80
dltC TIGR01688
D-alanine--poly(phosphoribitol) ligase, subunit 2; This protein is part of the teichoic acid ...
 24-76 1.09e-04

D-alanine--poly(phosphoribitol) ligase, subunit 2; This protein is part of the teichoic acid operon in gram-positive organisms. Gram positive organisms incorporate teichoic acid in their cell walls, and in the fatty acid residues of the glycolipid component of the outer layer of the cytoplasmic membrane. This gene, dltC, encodes the alanyl carrier protein. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 130749  Cd Length: 73  Bit Score: 36.74  E-value: 1.09e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 485652537  24 NDDDDIFSLGLVHSLFTVQIILFIEKNFQVELEVSELKTEQIATVNKIVELIQ 76
Cdd:TIGR01688 20 NPDLELFEEGLLDSFGTVQLLLEIQNQFDIDVPISEFDRDEWDTPNKIVAKLE 72
 
Name Accession Description Interval E-value
PRK07081 PRK07081
acyl carrier protein; Provisional
 6-78 1.81e-07

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 44.18  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485652537  6 MKAAIREFLSRSLR----GHTLNDDDDIFSLGLVhSLFTVQIILFIEKNFQVELEVSELKTEQIATVNKI---VELIQRQ 78
Cdd:PRK07081  1 MKNTIRTILKKVAKlevpIDSIADDADLYEAGLS-SLATVQLMLAIEDAFDIEIPDEMLNRKLFASIDALagaVTQLQDA 79
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-80 9.04e-07

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 42.15  E-value: 9.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485652537  1 MKKQDMKAAIREFLSRSLR--GHTLNDDDDIFS-LGLvHSLFTVQIILFIEKNFQVELEVSELktEQIATVNKIVELIQR 77
Cdd:COG0236   1 MPREELEERLAEIIAEVLGvdPEEITPDDSFFEdLGL-DSLDAVELIAALEEEFGIELPDTEL--FEYPTVADLADYLEE 77


                ...
gi 485652537 78 QTG 80
Cdd:COG0236  78 KLA 80
PRK05087 PRK05087
D-alanine--poly(phosphoribitol) ligase subunit DltC;
24-76 2.64e-06

D-alanine--poly(phosphoribitol) ligase subunit DltC;


Pssm-ID: 179929  Cd Length: 78  Bit Score: 41.10  E-value: 2.64e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 485652537 24 NDDDDIFSLGLVHSLFTVQIILFIEKNFQVELEVSELKTEQIATVNKIVELIQ 76
Cdd:PRK05087 23 NMDEDLFEEGILDSMGTVELLVELENRFDIEVPVSEFDRDDWNTPNKIIAKVE 75
dltC TIGR01688
D-alanine--poly(phosphoribitol) ligase, subunit 2; This protein is part of the teichoic acid ...
 24-76 1.09e-04

D-alanine--poly(phosphoribitol) ligase, subunit 2; This protein is part of the teichoic acid operon in gram-positive organisms. Gram positive organisms incorporate teichoic acid in their cell walls, and in the fatty acid residues of the glycolipid component of the outer layer of the cytoplasmic membrane. This gene, dltC, encodes the alanyl carrier protein. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 130749  Cd Length: 73  Bit Score: 36.74  E-value: 1.09e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 485652537  24 NDDDDIFSLGLVHSLFTVQIILFIEKNFQVELEVSELKTEQIATVNKIVELIQ 76
Cdd:TIGR01688 20 NPDLELFEEGLLDSFGTVQLLLEIQNQFDIDVPISEFDRDEWDTPNKIVAKLE 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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