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Conserved domains on  [gi|485666705|ref|WP_001307957|]
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MULTISPECIES: nucleotide exchange factor GrpE [Enterobacteriaceae]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793376)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-197 7.05e-131

heat shock protein GrpE; Provisional


:

Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 365.53  E-value: 7.05e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80
Cdd:PRK10325   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK10325  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 485666705 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
Cdd:PRK10325 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
 
Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-197 7.05e-131

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 365.53  E-value: 7.05e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80
Cdd:PRK10325   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK10325  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 485666705 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
Cdd:PRK10325 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 45-195 7.80e-58

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 178.42  E-value: 7.80e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  45 ANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIE 124
Cdd:COG0576    2 EELEAELAEL----KDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE-DEDVKSLLEGVE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485666705 125 LTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKA 195
Cdd:COG0576   77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 59-192 1.61e-56

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 175.00  E-value: 1.61e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  59 RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIELTLKSMLDVVRKFG 138
Cdd:cd00446    4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPK-EEELKNLLEGVEMTLKQLLKVLEKHG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 485666705 139 VEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTV 192
Cdd:cd00446   83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
33-194 6.40e-50

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 159.31  E-value: 6.40e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   33 SAEQVDPRDEKIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVA 109
Cdd:pfam01025   2 EKKNEEALTDEIESLEEEIEELEKKIEelkEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  110 dKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAM 189
Cdd:pfam01025  82 -PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAM 160


                  ....*
gi 485666705  190 VTVAK 194
Cdd:pfam01025 161 VVVSK 165
 
Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-197 7.05e-131

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 365.53  E-value: 7.05e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80
Cdd:PRK10325   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK10325  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 485666705 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
Cdd:PRK10325 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 1-194 1.95e-93

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 270.64  E-value: 1.95e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPDASAEqVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80
Cdd:PRK14150   1 MSNEEQKTPQEQVSEEIEAEVEQQEEADEAELEDE-LDEADARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAEQDV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK14150  80 EKAHKFALEKFANELLPVIDNLERALQAADKENEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQ 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 485666705 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14150 160 ESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 45-195 7.80e-58

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 178.42  E-value: 7.80e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  45 ANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIE 124
Cdd:COG0576    2 EELEAELAEL----KDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE-DEDVKSLLEGVE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485666705 125 LTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKA 195
Cdd:COG0576   77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 19-195 8.54e-57

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 176.89  E-value: 8.54e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  19 MDQHEEIEAVEPDASAEQVDPRDE---KIANLEAQLAEAQtrerDGILRVKAEMENLRRRTELDIEKAHKFALEKFINEL 95
Cdd:PRK14151   1 MADEQTLDLQAPEAAQAEAAAGDDltaRVQELEEQLAAAK----DQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  96 LPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQ 175
Cdd:PRK14151  77 LPVVDSLERGLELSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQ 156

                        170       180
                 ....*....|....*....|
gi 485666705 176 KGYTLNGRTIRAAMVTVAKA 195
Cdd:PRK14151 157 KGYLLNGRLLRPAMVVVSKA 176
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 59-192 1.61e-56

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 175.00  E-value: 1.61e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  59 RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIELTLKSMLDVVRKFG 138
Cdd:cd00446    4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPK-EEELKNLLEGVEMTLKQLLKVLEKHG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 485666705 139 VEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTV 192
Cdd:cd00446   83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
33-194 6.40e-50

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 159.31  E-value: 6.40e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   33 SAEQVDPRDEKIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVA 109
Cdd:pfam01025   2 EKKNEEALTDEIESLEEEIEELEKKIEelkEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  110 dKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAM 189
Cdd:pfam01025  82 -PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAM 160


                  ....*
gi 485666705  190 VTVAK 194
Cdd:pfam01025 161 VVVSK 165
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 5-196 7.40e-47

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 152.05  E-value: 7.40e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   5 EQKTPEGQAPEeiiMDQHEEIEAVEPDASAEQVDPrdekIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELDIE 81
Cdd:PRK14139   2 ENTQQNPSEQE---AEEAGAAAQAAAAAAAAAEDA----APALEAELAEAEAKAAelqDSFLRAKAETENVRRRAQEDVA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  82 KAHKFALEKFINELLPVIDSLDRALevADKaNPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVE 161
Cdd:PRK14139  75 KAHKFAIESFAESLLPVKDSLEAAL--ADE-SGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVP 151

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 485666705 162 SDDvAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK14139 152 AEQ-EPNTVVAVLQKGYTIADRVLRPALVTVAAPK 185
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 1-194 8.71e-42

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 139.36  E-value: 8.71e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKT--PEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTRErdgiLRVKAEMENLRRRTEL 78
Cdd:PRK14140   1 MEEKNEQVeeEVEETEVEEAVEDEVEEETVEEESEAELLDEEQAKIAELEAKLDELEERY----LRLQADFENYKRRIQK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  79 DIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIA 158
Cdd:PRK14140  77 ENEAAEKYRAQSLASDLLPALDNFERALQIEAD-DEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVM 155

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 485666705 159 MVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14140 156 QDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 20-194 6.29e-40

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 134.85  E-value: 6.29e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  20 DQHEEIEAVEPDASAEQVDPRDE---------KIANLEAQL--AEAQTRER-DGILRVKAEMENLRRRTELDIEKAHKFA 87
Cdd:PRK14144  14 DEHKEEHKVENEILEEETDEESQhqepalghpSYTALEEQLtlAEQKAHENwEKSVRALAELENVRRRMEREVANAHKYG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  88 LEKFINELLPVIDSLDRALEVADKANPdmSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAP 167
Cdd:PRK14144  94 VEKLISALLPVVDSLEQALQLADKNSD--PSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPP 171

                        170       180
                 ....*....|....*....|....*..
gi 485666705 168 GNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14144 172 NSVITVFQKGYKLSDRVIRPARVIVST 198
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 12-194 3.04e-37

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 127.74  E-value: 3.04e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  12 QAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLA--EAQTRER-DGILRVKAEMENLRRRTELDIEKAHKFAL 88
Cdd:PRK14158  10 QIAEALKAKAAKEAEAAQGKPEAAQPVAAADRIKELEEALAakEAEAAANwDKYLRERADLENYRKRVQKEKEELLKYGN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  89 EKFINELLPVIDSLDRALEVADKANpdMSAMVEGIELTLKSMLDVVRKFGVEVI-AETNVPLDPNVHQAIAMVESDDVAP 167
Cdd:PRK14158  90 ESLILEILPAVDNMERALDHADEES--MSAIIEGIRMTLSMLLSTLKKFGVTPVeAEKGTPFDPAYHQAMCQVESAEQEP 167

                        170       180
                 ....*....|....*....|....*..
gi 485666705 168 GNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14158 168 NTVVAVFQKGYLLNERLLRPAMVSVAT 194
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 19-194 3.52e-37

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 126.99  E-value: 3.52e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  19 MDQ-HEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTrerdGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLP 97
Cdd:PRK14147   1 MNQdHPEFDSEDLAQNPPETDPLKAEVESLRSEIALVKA----DALRERADLENQRKRIARDVEQARKFANEKLLGELLP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  98 VIDSLDRALEVAdkaNPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKG 177
Cdd:PRK14147  77 VFDSLDAGLTAA---GTEPSPLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKG 153

                        170
                 ....*....|....*..
gi 485666705 178 YTLNGRTIRAAMVTVAK 194
Cdd:PRK14147 154 YLLNERLLRPALVVVAK 170
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 3-197 4.18e-34

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 120.16  E-value: 4.18e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   3 SKEQKTPEGQAPEEIimdqhEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEK 82
Cdd:PRK14141   4 EKNKNGNPADAARDA-----NNPVDREAKPYEMEDDPEPDPLEALKAENAEL----KDRMLRLAAEMENLRKRTQRDVAD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  83 AHKFALEKFINELLPVIDSLDRAL-----EVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAI 157
Cdd:PRK14141  75 ARAYGIAGFARDMLSVSDNLRRALdaipaEARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAM 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 485666705 158 AMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
Cdd:PRK14141 155 FEVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGVAKGGP 194
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 2-194 4.78e-34

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 119.86  E-value: 4.78e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   2 SSKEQKTPEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEaqlaEAQTRERDGILRVKAEMENLRRRTELDIE 81
Cdd:PRK14148   7 SNVEDKSLDIETAAQVETAQESASGALEELSVEEQLERAKDTIKELE----DSCDQFKDEALRAKAEMENIRKRAERDVS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  82 KAHKFALEKFINELLPVIDSLDRALEVADKANPDMsAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVE 161
Cdd:PRK14148  83 NARKFGIEKFAKELLPVIDSIEQALKHEVKLEEAI-AMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIP 161

                        170       180       190
                 ....*....|....*....|....*....|...
gi 485666705 162 SDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14148 162 NPEFEDNTIFDVFQKGYMLNGRIVRAAKVVIVK 194
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 1-194 6.13e-30

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 108.81  E-value: 6.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKTPEGQAPEEiiMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDI 80
Cdd:PRK14149   4 EHNQEHDHLSQKEPES--EEKACACKEQQGEEKQEASEKEGEIKEDFELKYKEM----HEKYLRVHADFENVKKRLERDK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  81 EKAHKFALEKFINELLPVIDSLDRALEVAdKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIaETNVPLDPNVHQAIAMV 160
Cdd:PRK14149  78 SMALEYAYEKIALDLLPVIDALLGALKSA-AEVDKESALTKGLELTMEKLHEVLARHGIEGI-ECLEEFDPNFHNAIMQV 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 485666705 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14149 156 KSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 189
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 26-197 1.06e-28

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 106.20  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  26 EAVEPDASAEQVDPRDEKIANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRA 105
Cdd:PRK14155   4 EQTPAEDGPFEADDAAQEIEALKAEVAAL----KDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705 106 LEVA--DKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAET-NVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNG 182
Cdd:PRK14155  80 TAASpkDSADPAVKNFIIGVEMTEKELLGAFERNGLKKIDPAkGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMG 159

                        170
                 ....*....|....*
gi 485666705 183 RTIRAAMVTVAkAKA 197
Cdd:PRK14155 160 RLVRPAMVAVA-AKG 173
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 1-193 2.65e-28

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 105.28  E-value: 2.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKTPEGQAPE--EIIMDQHEEIEAVEPDASAEQVDPRD----EKIANLEAQLAEAQTR---ERDGILRVKAEMEN 71
Cdd:PRK14154   5 MSSKNNPESETKAKNkwEKVMEAEEEQEEGGGDGSQEMEPHREglefPSREKLEGQLTRMERKvdeYKTQYLRAQAEMDN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  72 LRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVI-AETNVPLD 150
Cdd:PRK14154  85 LRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVInPNPGDPFD 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 485666705 151 PNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVA 193
Cdd:PRK14154 165 PALHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARVIVA 207
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 15-194 4.86e-27

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 101.46  E-value: 4.86e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  15 EEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTRE-----RDGILRVKAEMENLRRRTELDIEKAHKFALE 89
Cdd:PRK14153   4 KEVGKDKAENSEARNSGSSAEEAEELKEEPEDSTADSETEKCREeieslKEQLFRLAAEFDNFRKRTAREMEENRKFVLE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  90 KFINELLPVIDSLDRALEVADKANpDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGN 169
Cdd:PRK14153  84 QVLLDLLEVTDNFERALESARTAE-DMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNT 162

                        170       180
                 ....*....|....*....|....*
gi 485666705 170 VLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14153 163 IVDVCKPGYALNSKVIRPAMVSVAR 187
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 20-194 4.27e-23

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 90.90  E-value: 4.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  20 DQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTRE-RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPV 98
Cdd:PRK14159   3 EQKQEFENENAENSEHLQDENLQNIEDVEQNKLQKDYDElKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  99 IDSLDRALEVadKANPDMSAMV-EGIELTLKSMLDVVRKFGVEVIAETNvPLDPNVHQAIAMVESDDVAPGNVLGIMQKG 177
Cdd:PRK14159  83 LDALEAAVNV--ECHDEISLKIkEGVQNTLDLFLKKLEKHGVALIKEEK-EFDPNLHEAMFHVDSENHQSGEVVQVLQKG 159

                        170
                 ....*....|....*..
gi 485666705 178 YTLNGRTIRAAMVTVAK 194
Cdd:PRK14159 160 YKIADRVIRPTKVSVAK 176
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 3-194 3.35e-22

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 88.74  E-value: 3.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   3 SKEQKTPEGQAPEEIIMDQHEEieAVEPDASAEQVDPRDEKIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELD 79
Cdd:PRK14162   2 SKEEFPSEKDLPQEETTDEAPK--KEAKEAPKEEDQEKQNPVEDLEKEIADLKAKNKdleDKYLRSQAEIQNMQNRYAKE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  80 IEKAHKFALEKFINELLPVIDSLDRALEVadKANPDMSAMVE-GIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIA 158
Cdd:PRK14162  80 RAQLIKYESQSLAKDVLPAMDNLERALAV--KADDEAAKQLKkGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQ 157

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 485666705 159 MVESDDVAP-GNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14162 158 TVAAENDDQkDHVVQVLQKGYQYKDRTLRPAMVVVAQ 194
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 23-194 1.91e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 86.90  E-value: 1.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  23 EEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQtRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSL 102
Cdd:PRK14145  30 EDEQAQQNQPQQQTVDEIEELKQKLQQKEVEAQ-EYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705 103 DRALEvadkANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNG 182
Cdd:PRK14145 109 ERALA----SSGDYNSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEIIEVFQKGYYLKD 184

                        170
                 ....*....|..
gi 485666705 183 RTIRAAMVTVAK 194
Cdd:PRK14145 185 KVIRPSLVKVAK 196
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 9-196 6.06e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 85.95  E-value: 6.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   9 PEGQAPEeiimDQHEEIEAVEPDASAEQVDPRdekiANLEAQLAEAQTR--ERDGIL-RVKAEMENLRRRTELDIEKAHK 85
Cdd:PRK14163  15 PSGATPD----DAEPKAASEEGAAPAGDAAAT----AGLTAQLDQVRTAlgERTADLqRLQAEYQNYRRRVERDRVTVKE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  86 FALEKFINELLPVIDSLDRALEVADkanpdmsaMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDV 165
Cdd:PRK14163  87 IAVANLLSELLPVLDDVGRAREHGE--------LVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDV 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 485666705 166 APGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK14163 159 TETTCVAILQPGYRIGERTIRPARVAVAEPQ 189
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 1-194 6.24e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 85.96  E-value: 6.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKiANLEAQLAEAQTRerdgILRVKAEMENLRRRTELDI 80
Cdd:PRK14160  28 KGKEEDLEFEEIEKEEIIEDSEESNEVKIEELKDENNKLKEEN-KKLENELEALKDR----LLRTVAEYDNYRKRTAKEK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  81 EKAHKFALEKFINELLPVIDSLDRALEVadkaNPDMSAMVEGIELTLKSMLDVVRKFGVEVIaETNVPLDPNVHQAIAMV 160
Cdd:PRK14160 103 EGIYSDACEDVLKELLPVLDNLERAAAV----EGSVEDLKKGIEMTVKQFKTSLEKLGVEEI-STEGEFDPNLHNAVMHV 177

                        170       180       190
                 ....*....|....*....|....*....|....
gi 485666705 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14160 178 EDENYGENEIVEVFQKGYKRGDKVIRYSMVKVAN 211
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 2-196 8.34e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 86.32  E-value: 8.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   2 SSKEQKTPEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANLEAQLA----EAQTRErDGILRVKAEMENLRRRTE 77
Cdd:PRK14143  27 SSEEVTEQEAELTNPEGDAAEAESSPDSGSAASETAADNAARLAQLEQELEslkqELEELN-SQYMRIAADFDNFRKRTS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  78 LDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAI 157
Cdd:PRK14143 106 REQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSYQGLYKQLVDVLKRLGVSPMRVVGQEFDPNLHEAV 185

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 485666705 158 AMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK14143 186 LREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVSMGP 224
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 20-194 5.28e-20

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 82.71  E-value: 5.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  20 DQHEEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQtrerDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVI 99
Cdd:PRK14161   4 DNIENNEQTINDIAEEIVETANPEITALKAEIEELK----DKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705 100 DSLDRALE-VADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIA-ETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKG 177
Cdd:PRK14161  80 DNLSRALAhKPANSDVEVTNIIAGVQMTKDELDKVFHKHHIEEIKpEIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSG 159

                        170
                 ....*....|....*..
gi 485666705 178 YTLNGRTIRAAMVTVAK 194
Cdd:PRK14161 160 YKIRDRLLRPATVQVVK 176
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 5-193 2.92e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 79.07  E-value: 2.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   5 EQKTPEGQAPEEIIMDQHEEIEAVEPDASAEQVDPRDEkiANLEAQLAEaqtRERDgILRVKAEMENLRRRTELDIEKAH 84
Cdd:PRK14164  42 EDDPFGDAVEGEIDPDLEADLEDLLDDVDPELADDGEA--STVEAQLAE---RTED-LQRVTAEYANYRRRTERERQAII 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  85 KFALEKFINELLPVIDSLDRALEVADkanpdmsaMVEGielTLKSMLD----VVRKFGVEVIAETNVPLDPNVHQAIA-M 159
Cdd:PRK14164 116 ETAKAGVATDLLPILDDLDLAEQHGD--------LNEG---PLKAFSDkltnVLAGLKVEKFGEEGDAFDPEIHEAVQdL 184

                        170       180       190
                 ....*....|....*....|....*....|....
gi 485666705 160 VESDDVAPGNVLgimQKGYTLNGRTIRAAMVTVA 193
Cdd:PRK14164 185 SSGDEKVLGTVL---RKGYRMGDRVLRTAMVIIA 215
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 2-197 6.54e-16

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 72.84  E-value: 6.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   2 SSKEQKTPEGQAPEEIIMD------QHEEIEAVEPDASAEQVDPRDEKIAnLEAQLAEAQTR---ERDGILRVKAEMENL 72
Cdd:PRK14146   9 TSEEAKANEKKSQSQTLEEsklenmNSEESQTITEETQEQAVEGAETETS-LQKELDNAKKEiesLKDSWARERAEFQNF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  73 RRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKAnPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPN 152
Cdd:PRK14146  88 KRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQS-EELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPM 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 485666705 153 VHQAIAMVESDDVAPGNVLGIMQKGYTL----NGRTIRAAMVTVAKAKA 197
Cdd:PRK14146 167 SMEALSSEEGDQYSEETVIDVYQAGYYYkeneDKFTLRPARVRIGKPKS 215
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 15-194 1.39e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 71.02  E-value: 1.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  15 EEIIMDQH-EEIEAVEPDASAEQVDPRDEKIANLEAQLAEAQTRErDGILRVKAEMENLRRRTELDIEKAHKFALEKFIN 93
Cdd:PRK14156   3 EEIKNEEVeEEVEATETEETVEEVVEETPEKSELELANERADEFE-NKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  94 ELLPVIDSLDRALEVaDKANPDMSamvEGIELTLKSMLDVVRKFGVEVIAETNvpLDPNVHQAIAMVESDDVAPGNVLG- 172
Cdd:PRK14156  82 AILPSLDNLERALAV-EGLTDDVK---KGLEMVQESLIQALKEEGVEEVAVDS--FDHNLHMAVQTLPADDEHPADSIAq 155

                        170       180
                 ....*....|....*....|..
gi 485666705 173 IMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14156 156 VFQKGYKLHERLLRPAMVVVYN 177
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 12-193 2.02e-09

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 54.96  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  12 QAPEEIIMDQHEEIEAVEPDASAEQVDPRDEKIANL------EAQLAEAQTRERdgilrvkAEMENLRRRTELDIEKAHK 85
Cdd:PRK14157  51 NAGADAAPAAAEGEAKAAAEKTGEAQSDSDDTLTPLgqakkeAAEYLEALQRER-------AEFINYRNRTQKEQDRFRQ 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  86 FALEKFINELLPVIDSLDRALEvadkanpdMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDV 165
Cdd:PRK14157 124 HGIIDVLTALLPALDDIDRIRE--------HSEMDDSFKAVAAKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKPDPDA 195

                        170       180
                 ....*....|....*....|....*...
gi 485666705 166 APGNVLGIMQKGYTLNGRTIRAAMVTVA 193
Cdd:PRK14157 196 EKETVDTVVEAGYRIGDRVIRAARVVVA 223
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 9-192 1.59e-07

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 49.61  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705   9 PEGQAPEEI-IMDQHE------EIEAVEPD-----ASAEQVDPRDEKIANLEAQLAeaqtrerdgilRVKAEMENLRRRT 76
Cdd:PRK14142   2 PDGNSGEQVtVTDKRRidpetgEVRHVPPGdmpggTAAADAAHTEDKVAELTADLQ-----------RVQADFANYRKRA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485666705  77 ELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVrkFGVEviaetNVPLDPNVHQA 156
Cdd:PRK14142  71 LRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGPLKSVADKLDSALTGLGLVA--FGAE-----GEDFDPVLHEA 143

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 485666705 157 IAMVESDDVAPGNVLG-IMQKGYTLNGRTIRAAMVTV 192
Cdd:PRK14142 144 VQHEGDGGQGSKPVIGtVMRQGYQLGEQVLRHALVGV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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