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Conserved domains on  [gi|485707991|ref|WP_001340618|]
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MULTISPECIES: pyrimidine utilization protein A [Enterobacteriaceae]

Protein Classification

pyrimidine utilization protein A( domain architecture ID 10022703)

pyrimidine utilization protein A catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RutA TIGR03612
pyrimidine utilization protein A; This protein is observed in operons extremely similar to ...
 1-355 0e+00

pyrimidine utilization protein A; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the luciferase family defined by pfam00296 and is likely a FMN-dependent monoxygenase. [Unknown function, Enzymes of unknown specificity]


:

Pssm-ID: 163355  Cd Length: 355  Bit Score: 762.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991    1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80
Cdd:TIGR03612   1 MDIGVFIPIGNNGWLISENAPQYMPSFELNKAIVQKAEQYGFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKS 160
Cdd:TIGR03612  81 IKLYATAATLTLPPAIVARMASTIDSISNGRFGVNLVTGWQKPEYSQMGLWPGDEYFADRYEYLAEYVQVLRELWETGVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  161 DFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVL 240
Cdd:TIGR03612 161 DFKGEFFQMDDCRVSPRPQAEMKIICAGQSDAGMAFSAQYADYNFCFGKGVNTPTAFAPTAARLLAAAEKTGRDVGSYVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  241 FMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAS 320
Cdd:TIGR03612 241 FMVIADETDEAARAKWEHYKDGADEEALAWLTLQGAKDTKSGADTNVRQMADPTSAVNINMGTLVGSYETVARMLDEVAE 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 485707991  321 VPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHL 355
Cdd:TIGR03612 321 VPGTGGVLLTFDDFLEGVEDFGTRIQPLMTSRAHV 355
 
Name Accession Description Interval E-value
RutA TIGR03612
pyrimidine utilization protein A; This protein is observed in operons extremely similar to ...
 1-355 0e+00

pyrimidine utilization protein A; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the luciferase family defined by pfam00296 and is likely a FMN-dependent monoxygenase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 163355  Cd Length: 355  Bit Score: 762.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991    1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80
Cdd:TIGR03612   1 MDIGVFIPIGNNGWLISENAPQYMPSFELNKAIVQKAEQYGFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKS 160
Cdd:TIGR03612  81 IKLYATAATLTLPPAIVARMASTIDSISNGRFGVNLVTGWQKPEYSQMGLWPGDEYFADRYEYLAEYVQVLRELWETGVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  161 DFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVL 240
Cdd:TIGR03612 161 DFKGEFFQMDDCRVSPRPQAEMKIICAGQSDAGMAFSAQYADYNFCFGKGVNTPTAFAPTAARLLAAAEKTGRDVGSYVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  241 FMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAS 320
Cdd:TIGR03612 241 FMVIADETDEAARAKWEHYKDGADEEALAWLTLQGAKDTKSGADTNVRQMADPTSAVNINMGTLVGSYETVARMLDEVAE 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 485707991  321 VPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHL 355
Cdd:TIGR03612 321 VPGTGGVLLTFDDFLEGVEDFGTRIQPLMTSRAHV 355
Alkanesulfonate_monoxygenase cd01094
Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the ...
 1-258 2.34e-80

Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).


Pssm-ID: 238527 [Multi-domain]  Cd Length: 244  Bit Score: 245.65  E-value: 2.34e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMiklrgfggkteFWDHNLESFTLMAGLAAVTSR 80
Cdd:cd01094    1 LEFGWFIPNVSGGWSLSTPPRGRPWDFEYNRQIAQAAEELGFDGALSP-----------TGSSGPDGWTVAAALAAATER 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDyfsRRYDYLTEYVQVLRDLW-GTGK 159
Cdd:cd01094   70 LKFLVAIRPGLIAPTVAARQAATLDHISGGRLGLNVVTGGDPAELRMDGDFLDHD---ERYARADEFLEVLRRLWtSDEP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 160 SDFKGDF--FTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:cd01094  147 FDFEGKFyrFKNAFLRPKPPQQPHPPIYFGGSSEAAIEFAARHADVYFTWG---EPPAQVAEAIARVRAAAAAAGRDVRF 223

                        250       260
                 ....*....|....*....|.
gi 485707991 238 YVLFMVIADETDDAARAKWEH 258
Cdd:cd01094  224 GIRLHVIVRDTEEEAWAYADR 244
SsuD COG2141
Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase ...
 37-350 3.48e-59

Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) [Coenzyme transport and metabolism, General function prediction only]; Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441744 [Multi-domain]  Cd Length: 301  Bit Score: 193.23  E-value: 3.48e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  37 AEHYHFDFALSMIKLRGFGGktefwdHNLESFTLMAGLAAVTSRIQIYATAATLTL-PPAIVARMAATIDSISGGRFGVN 115
Cdd:COG2141    1 AERLGFDRVWVADHHFPPGG------ASPDPWVLLAALAAATSRIRLGTGVVVLPLrHPLVVAEQFATLDHLSGGRLDLG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 116 LVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQP----SVPmkVICAGQSD 191
Cdd:COG2141   75 VGRGWGPDEFAAFGL-----DHDERYERFEEALEVLRRLWTGEPVTFEGEFFTVEGARLVPRPvqgpHPP--IWIAGSSP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 192 AGMAFSARYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS---YVLFMVIADETDDAARakwehykagadEEAL 268
Cdd:COG2141  148 AGARLAARLGDGVFTAG---GTPEELAEAIAAYREAAAAAGRDPDDlrvSVGLHVIVAETDEEAR-----------ERAR 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 269 SWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTF-----DDFLSGIETFGE 343
Cdd:COG2141  214 PYLRALLALPRGRPPEEAEEGLTVREDLLELLGAALVGTPEQVAERLEELAEAAGVDEFLLQFpgldpEDRLRSLELFAE 293


                 ....*..
gi 485707991 344 RIQPLMQ 350
Cdd:COG2141  294 EVLPLLR 300
Bac_luciferase pfam00296
Luciferase-like monooxygenase;
1-320 1.52e-49

Luciferase-like monooxygenase;


Pssm-ID: 425589 [Multi-domain]  Cd Length: 313  Bit Score: 168.69  E-value: 1.52e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991    1 MKIGVFVPIGNNGWListHAPQymPTFELNKAIVQKAEHYHFDFALSmiklrgfggkTEFW--DHNLESFTLMAGLAAVT 78
Cdd:pfam00296   1 MEFGVFLPTRNGGGL---GAGS--ESLRYLVELARAAEELGFDGVWL----------AEHHggPGGPDPFVVLAALAAAT 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   79 SRIQIYATAATL-TLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGT 157
Cdd:pfam00296  66 SRIRLGTAVVPLpTRHPAVLAEQAATLDHLSGGRFDLGLGTGGPAVEFRRFGV-----DHDERYARLREFLEVLRRLWRG 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  158 GKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFgkGVNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:pfam00296 141 EPVDFEGEFFTLDGAFLLPRPVQGIPVWVAASSPAMLELAARHADGLLLW--GFAPPAAAAELIERVRAGAAEAGRDPAD 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  238 ---YVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDT----NVRQMADPTSAVNINMGTLVGSYAS 310
Cdd:pfam00296 219 irvGASLTVIVADTEEEARAEARALIAGLPFYRMDSEGAGRLAEAREIGEEydagDWAGAADAVPDELVRAFALVGTPEQ 298

                         330
                  ....*....|
gi 485707991  311 VARMLDEVAS 320
Cdd:pfam00296 299 VAERLAAYAE 308
PRK00719 PRK00719
alkanesulfonate monooxygenase; Provisional
 72-273 4.64e-16

alkanesulfonate monooxygenase; Provisional


Pssm-ID: 234821 [Multi-domain]  Cd Length: 378  Bit Score: 78.46  E-value: 4.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  72 AGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEqmgiwpGDDYF---SRRYDYLTEYV 148
Cdd:PRK00719  61 ASLIPVTQRLKFLVALRPGLMSPTVAARMAATLDRLSNGRLLINLVTGGDPAELA------GDGLFldhDERYEASAEFL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 149 QVLRDLWGTGKSDFKGDFFTMNDCRV------SPQPSVPMkvicAGQSDAGMAFSARYADFNFCFGKgvnTPTAFAPTAA 222
Cdd:PRK00719 135 RIWRRLLEGETVDFEGKHIQVKGAKLlfppvqQPYPPLYF----GGSSDAAQELAAEQVDLYLTWGE---PPAQVKEKIE 207

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 485707991 223 RMKQAAEQTGRDVGSYVLFMVIADETDDAArakWEhykagADEEALSWLTE 273
Cdd:PRK00719 208 QVRAKAAAHGRKVRFGIRLHVIVRETNEEA---WQ-----AAERLISHLDD 250
 
Name Accession Description Interval E-value
RutA TIGR03612
pyrimidine utilization protein A; This protein is observed in operons extremely similar to ...
 1-355 0e+00

pyrimidine utilization protein A; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the luciferase family defined by pfam00296 and is likely a FMN-dependent monoxygenase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 163355  Cd Length: 355  Bit Score: 762.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991    1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80
Cdd:TIGR03612   1 MDIGVFIPIGNNGWLISENAPQYMPSFELNKAIVQKAEQYGFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKS 160
Cdd:TIGR03612  81 IKLYATAATLTLPPAIVARMASTIDSISNGRFGVNLVTGWQKPEYSQMGLWPGDEYFADRYEYLAEYVQVLRELWETGVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  161 DFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVL 240
Cdd:TIGR03612 161 DFKGEFFQMDDCRVSPRPQAEMKIICAGQSDAGMAFSAQYADYNFCFGKGVNTPTAFAPTAARLLAAAEKTGRDVGSYVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  241 FMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAS 320
Cdd:TIGR03612 241 FMVIADETDEAARAKWEHYKDGADEEALAWLTLQGAKDTKSGADTNVRQMADPTSAVNINMGTLVGSYETVARMLDEVAE 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 485707991  321 VPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHL 355
Cdd:TIGR03612 321 VPGTGGVLLTFDDFLEGVEDFGTRIQPLMTSRAHV 355
Alkanesulfonate_monoxygenase cd01094
Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the ...
 1-258 2.34e-80

Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).


Pssm-ID: 238527 [Multi-domain]  Cd Length: 244  Bit Score: 245.65  E-value: 2.34e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   1 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMiklrgfggkteFWDHNLESFTLMAGLAAVTSR 80
Cdd:cd01094    1 LEFGWFIPNVSGGWSLSTPPRGRPWDFEYNRQIAQAAEELGFDGALSP-----------TGSSGPDGWTVAAALAAATER 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  81 IQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDyfsRRYDYLTEYVQVLRDLW-GTGK 159
Cdd:cd01094   70 LKFLVAIRPGLIAPTVAARQAATLDHISGGRLGLNVVTGGDPAELRMDGDFLDHD---ERYARADEFLEVLRRLWtSDEP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 160 SDFKGDF--FTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:cd01094  147 FDFEGKFyrFKNAFLRPKPPQQPHPPIYFGGSSEAAIEFAARHADVYFTWG---EPPAQVAEAIARVRAAAAAAGRDVRF 223

                        250       260
                 ....*....|....*....|.
gi 485707991 238 YVLFMVIADETDDAARAKWEH 258
Cdd:cd01094  224 GIRLHVIVRDTEEEAWAYADR 244
SsuD COG2141
Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase ...
 37-350 3.48e-59

Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) [Coenzyme transport and metabolism, General function prediction only]; Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441744 [Multi-domain]  Cd Length: 301  Bit Score: 193.23  E-value: 3.48e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  37 AEHYHFDFALSMIKLRGFGGktefwdHNLESFTLMAGLAAVTSRIQIYATAATLTL-PPAIVARMAATIDSISGGRFGVN 115
Cdd:COG2141    1 AERLGFDRVWVADHHFPPGG------ASPDPWVLLAALAAATSRIRLGTGVVVLPLrHPLVVAEQFATLDHLSGGRLDLG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 116 LVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQP----SVPmkVICAGQSD 191
Cdd:COG2141   75 VGRGWGPDEFAAFGL-----DHDERYERFEEALEVLRRLWTGEPVTFEGEFFTVEGARLVPRPvqgpHPP--IWIAGSSP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 192 AGMAFSARYADFNFCFGkgvNTPTAFAPTAARMKQAAEQTGRDVGS---YVLFMVIADETDDAARakwehykagadEEAL 268
Cdd:COG2141  148 AGARLAARLGDGVFTAG---GTPEELAEAIAAYREAAAAAGRDPDDlrvSVGLHVIVAETDEEAR-----------ERAR 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 269 SWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTF-----DDFLSGIETFGE 343
Cdd:COG2141  214 PYLRALLALPRGRPPEEAEEGLTVREDLLELLGAALVGTPEQVAERLEELAEAAGVDEFLLQFpgldpEDRLRSLELFAE 293


                 ....*..
gi 485707991 344 RIQPLMQ 350
Cdd:COG2141  294 EVLPLLR 300
Bac_luciferase pfam00296
Luciferase-like monooxygenase;
1-320 1.52e-49

Luciferase-like monooxygenase;


Pssm-ID: 425589 [Multi-domain]  Cd Length: 313  Bit Score: 168.69  E-value: 1.52e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991    1 MKIGVFVPIGNNGWListHAPQymPTFELNKAIVQKAEHYHFDFALSmiklrgfggkTEFW--DHNLESFTLMAGLAAVT 78
Cdd:pfam00296   1 MEFGVFLPTRNGGGL---GAGS--ESLRYLVELARAAEELGFDGVWL----------AEHHggPGGPDPFVVLAALAAAT 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   79 SRIQIYATAATL-TLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIwpgddYFSRRYDYLTEYVQVLRDLWGT 157
Cdd:pfam00296  66 SRIRLGTAVVPLpTRHPAVLAEQAATLDHLSGGRFDLGLGTGGPAVEFRRFGV-----DHDERYARLREFLEVLRRLWRG 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  158 GKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFgkGVNTPTAFAPTAARMKQAAEQTGRDVGS 237
Cdd:pfam00296 141 EPVDFEGEFFTLDGAFLLPRPVQGIPVWVAASSPAMLELAARHADGLLLW--GFAPPAAAAELIERVRAGAAEAGRDPAD 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  238 ---YVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDT----NVRQMADPTSAVNINMGTLVGSYAS 310
Cdd:pfam00296 219 irvGASLTVIVADTEEEARAEARALIAGLPFYRMDSEGAGRLAEAREIGEEydagDWAGAADAVPDELVRAFALVGTPEQ 298

                         330
                  ....*....|
gi 485707991  311 VARMLDEVAS 320
Cdd:pfam00296 299 VAERLAAYAE 308
F420_Rv1855c TIGR03560
probable F420-dependent oxidoreductase, Rv1855c family; Coenzyme F420 has a limited ...
 65-234 3.99e-27

probable F420-dependent oxidoreductase, Rv1855c family; Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274648 [Multi-domain]  Cd Length: 227  Bit Score: 107.02  E-value: 3.99e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   65 LESFTLMAGLAAVTSRIQIYA--TAATLTLPpAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDdyFSRRYD 142
Cdd:TIGR03560  50 LEAWTTLAGLARETSRIRLGTlvTGVTYRHP-GLLAKMVATVDVLSGGRAELGLGAGWYEREHRAYGIPFPP--LAERFE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  143 YLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMK---VICAGQSDAGMAFSARYAD-FNFCFGkgvnTPTAFA 218
Cdd:TIGR03560 127 RLEEALQIITGMWSGEGVTFDGRHYRLADAIALPKPLQRPHppiLIGGGGEKRTLRLAARYADeFNLVFG----PPDELA 202

                         170
                  ....*....|....*.
gi 485707991  219 PTAARMKQAAEQTGRD 234
Cdd:TIGR03560 203 HKFEVLRAHCEAAGRD 218
F420_Rv2161c TIGR03619
probable F420-dependent oxidoreductase, Rv2161c family; Coenzyme F420 has a limited ...
 56-265 2.92e-25

probable F420-dependent oxidoreductase, Rv2161c family; Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274680 [Multi-domain]  Cd Length: 246  Bit Score: 102.34  E-value: 2.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   56 GKTEFWDHNLESFTLMAGLAAVTSRIQIyATAATLtLP---PAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGiwp 132
Cdd:TIGR03619  35 GGGDAPDRTLDPFVALAFAAAVTSRLRL-GTGVLV-LPqrdPLLLAKQAATLDLLSGGRLRLGVGVGWLREEFRALG--- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  133 GDdyFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVI-CAGQSDAGMAFSARYADFNFCFGKGV 211
Cdd:TIGR03619 110 VD--FDERGRLLDEAIEALRALWTQDPVSFHGEFVDFDPAVVRPKPVQRPPPIwIGGNSEAALRRAARLGDGWMPFGPPV 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 485707991  212 ntpTAFAPTAARMKQAAEQTGRDVGS--YVLFMVIADETDDAARAKWEHY-KAGADE 265
Cdd:TIGR03619 188 ---DRLAAAVARLRDLAAAAGRDPDAveVVLVRTDPDGDADADAEDLAAYaDLGVTR 241
Nitrilotriacetate_monoxgenase cd01095
nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin ...
 1-236 2.26e-24

nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2.


Pssm-ID: 238528 [Multi-domain]  Cd Length: 358  Bit Score: 102.40  E-value: 2.26e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   1 MKIGVFVPignnGWLISTHAPQYMPT------FELNKAIVQKAEHYHFDFA-----LSMIKLRGFGGKTEFwdhnlESFT 69
Cdd:cd01095    1 LHLGAFLH----GAGHHAAAWRHPAPpdasidFDHYVRLARTAERAKFDAVfladgLAIRALSRPHPVARL-----EPLT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  70 LMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIwpgDDYFSR--RYDYLTEY 147
Cdd:cd01095   72 LLAALAAVTERIGLVATASTTYNEPYHLARRFASLDHISGGRAGWNVVTSANPGEARNFGR---DEHPEHdeRYARAEEF 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 148 VQVLRDLWGTGKSD---------------------FKGDFFtmndcRVSPQPSVPMK-----VIC-AGQSDAGMAFSARY 200
Cdd:cd01095  149 VEVVKGLWDSWEDDalvrdkasgrfadpakvhpldHVGDHF-----GVRGPLNGPRSpqgrpVIVqAGSSEAGREFAARH 223

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 485707991 201 ADFNFcfgKGVNTPTAFAPTAARMKQAAEQTGRDVG 236
Cdd:cd01095  224 AEAVF---TAQQTLEEAQAFYADVKARAAAAGRLDP 256
F420_G6P_family TIGR03557
F420-dependent oxidoreductase, G6PDH family; Members of this protein family include ...
 69-254 1.84e-16

F420-dependent oxidoreductase, G6PDH family; Members of this protein family include F420-dependent glucose-6-phosphate dehydrogenases (TIGR03554) and related proteins. All members of this family come from species that synthesize coenzyme F420, with the exception of those that belong to TIGR03885, a clade within this family in which cofactor binding may instead be directed to FMN. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274645  Cd Length: 316  Bit Score: 78.96  E-value: 1.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991   69 TLMAGLAAVTSRIQI--YATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDyfsRRYDYLTE 146
Cdd:TIGR03557  51 SVLGALAQATERLPLttAVTCPTMRYHPAIVAQAAATSAVLSDGRFTLGLGSGENLNEHVVGDGWPSVD---VRLEMLRE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  147 YVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFcfgkgvntptAFAPTAARMKQ 226
Cdd:TIGR03557 128 AVEIIRELWQGGYVDHRGKHYTVDSARLYDLPEEPPPIGVSAFGPRAVRLAARIGDGLI----------ATEPDADLVEA 197

                         170       180
                  ....*....|....*....|....*...
gi 485707991  227 AAEQTGRDVGSYVLFMVIADETDDAARA 254
Cdd:TIGR03557 198 FREAGGGGKPVQGQVPVCWDPDEDAAVK 225
PRK00719 PRK00719
alkanesulfonate monooxygenase; Provisional
 72-273 4.64e-16

alkanesulfonate monooxygenase; Provisional


Pssm-ID: 234821 [Multi-domain]  Cd Length: 378  Bit Score: 78.46  E-value: 4.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  72 AGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEqmgiwpGDDYF---SRRYDYLTEYV 148
Cdd:PRK00719  61 ASLIPVTQRLKFLVALRPGLMSPTVAARMAATLDRLSNGRLLINLVTGGDPAELA------GDGLFldhDERYEASAEFL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 149 QVLRDLWGTGKSDFKGDFFTMNDCRV------SPQPSVPMkvicAGQSDAGMAFSARYADFNFCFGKgvnTPTAFAPTAA 222
Cdd:PRK00719 135 RIWRRLLEGETVDFEGKHIQVKGAKLlfppvqQPYPPLYF----GGSSDAAQELAAEQVDLYLTWGE---PPAQVKEKIE 207

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 485707991 223 RMKQAAEQTGRDVGSYVLFMVIADETDDAArakWEhykagADEEALSWLTE 273
Cdd:PRK00719 208 QVRAKAAAHGRKVRFGIRLHVIVRETNEEA---WQ-----AAERLISHLDD 250
Tetrahydromethanopterin_reductase cd01097
N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5, ...
 102-268 6.07e-07

N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420.


Pssm-ID: 238530 [Multi-domain]  Cd Length: 202  Bit Score: 49.32  E-value: 6.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 102 ATIDSISGGRFGVNLVTGWQKPEYEQMGIWPgdDYFSRRYDYLTEYVQVLRDLWGTGKSDFkGDFFTMNDCRVS--PQPS 179
Cdd:cd01097   34 VSLDALSGGRFILGLGAGGPEVEEGWGGPWF--KPPARRREELEAIRRLRALRRGDPVGED-GRFLGTRSAALPppPRGE 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 180 VPmkVICAGQSDAGMAFSARYADfnfcfgkGVNTPTAFAPTAARMKQAAEQTGRDVGSyvlfmVIADETDDAARAKwEHY 259
Cdd:cd01097  111 IP--IYIGALGPKMLELAGEIAD-------GWLPVAAPPELYEAALPAVREGAAAAGR-----VVGDPDDVAEALR-RYR 175


                 ....*....
gi 485707991 260 KAGADEEAL 268
Cdd:cd01097  176 EAGVTEVVL 184
PRK02271 PRK02271
methylenetetrahydromethanopterin reductase; Provisional
 34-253 6.34e-07

methylenetetrahydromethanopterin reductase; Provisional


Pssm-ID: 235022 [Multi-domain]  Cd Length: 325  Bit Score: 50.71  E-value: 6.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991  34 VQKAEHYHFDFAlsmiklrgfggktefW--DH--NLESFTLMAGLAAVTSRIQIyATAAT--LTLPPAIVARMAATIDSI 107
Cdd:PRK02271  20 AKLAEDNGFDYA---------------WitDHynNRDVYMTLAAIAAATDTIKL-GPGVTnpYTRHPAITASAIATLDEI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 108 SGGR--FGV---------NLVTGWQKPeyeqmgiwpgddyfSRRydyLTEYVQVLRDLWGTGKSDFKGDFFTMNDC-RVS 175
Cdd:PRK02271  84 SGGRavLGIgpgdkatldALGIEWEKP--------------LRT---VKEAIEVIRKLWAGERVEHDGTFKAAGAKlNVK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485707991 176 PQP-SVPMKVicAGQSDAGMAFSARYADfnfcfGKGVNT--PTAFAPTAARMKQAAEQTGR-----DVGSYVLFMViaDE 247
Cdd:PRK02271 147 PVQgEIPIYM--GAQGPKMLELAGEIAD-----GVLINAsnPKDFEWAVPLIKKGAEEAGKsrgefDVAAYASVSV--DK 217


                 ....*.
gi 485707991 248 TDDAAR 253
Cdd:PRK02271 218 DEDKAR 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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