|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
1-386 |
0e+00 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 801.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK08045 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 81 HLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKIC 160
Cdd:PRK08045 81 HLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKIC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 161 HLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL 240
Cdd:PRK08045 161 HLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 241 LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSL 320
Cdd:PRK08045 241 LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485721626 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG 386
Cdd:PRK08045 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG 386
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
2-383 |
0e+00 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 742.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 2 TRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIH 81
Cdd:TIGR02080 1 TRKQATIAVRSGLNSDTQYGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 82 LVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICH 161
Cdd:TIGR02080 81 LVTTALLGPDDLLVAPHDCYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 162 LAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLL 241
Cdd:TIGR02080 161 LAKAVGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 242 LRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLF 321
Cdd:TIGR02080 241 LRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLF 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485721626 322 TLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:TIGR02080 321 TLAESLGGVESLIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
6-381 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 575.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTT 85
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 86 VFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLARE 165
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 166 VGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGL 245
Cdd:pfam01053 161 HGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 246 RTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAE 325
Cdd:pfam01053 241 KTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSLAV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 485721626 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:pfam01053 321 SLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
4-383 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 556.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 4 KQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:COG0626 2 GPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAArfageeggYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 76 GMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVD 155
Cdd:COG0626 82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 156 IAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGA 235
Cdd:COG0626 162 IAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 236 FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFL 315
Cdd:COG0626 242 FDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARRFL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 316 GGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:COG0626 322 DALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
2-383 |
0e+00 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 552.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 2 TRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIH 81
Cdd:PRK08861 3 TRKPATIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 82 LVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICH 161
Cdd:PRK08861 83 LWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 162 LAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLL 241
Cdd:PRK08861 163 KAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 242 LRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLF 321
Cdd:PRK08861 243 LRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALF 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485721626 322 TLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK08861 323 SLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKA 384
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
21-381 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 516.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 21 GCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGD 92
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADlfalreggYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 93 LLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVV 172
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 173 DNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRM 252
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 253 ELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVES 332
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 485721626 333 LISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
6-383 |
0e+00 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 512.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTT 85
Cdd:PRK08776 14 ATAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 86 VFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLARE 165
Cdd:PRK08776 94 ALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 166 VGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGL 245
Cdd:PRK08776 174 VGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 246 RTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAE 325
Cdd:PRK08776 254 RTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAE 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK08776 334 SLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
6-382 |
1.40e-144 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 415.58 E-value: 1.40e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA-HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVT 84
Cdd:PRK07811 14 ATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRGgYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDCLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 85 TVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAR 164
Cdd:PRK07811 94 RAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELAH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 165 EVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRG 244
Cdd:PRK07811 174 DAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLRG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 245 LRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLA 324
Cdd:PRK07811 254 LKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCARTKVFTLA 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485721626 325 ESLGGVESLISHAATMTHAgmapearAAAG----ISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK07811 334 ESLGGVESLIEHPSAMTHA-------STAGsqleVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
1-380 |
1.05e-128 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 374.83 E-value: 1.05e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKqaTIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK07671 1 MRAK--TKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 81 HLVTTVFlKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKIC 160
Cdd:PRK07671 79 TAVMMLF-SSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 161 HLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL 240
Cdd:PRK07671 158 TIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 241 LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELdGDEQTLRRFLGGLSL 320
Cdd:PRK07671 238 LLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQY 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGF 380
Cdd:PRK07671 317 FTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQAL 376
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
1-384 |
4.64e-126 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 367.49 E-value: 4.64e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK08247 1 QMSTIETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 81 HLVTTVFlKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKIC 160
Cdd:PRK08247 81 QLVMSLF-RSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 161 HLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL 240
Cdd:PRK08247 160 KIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 241 LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPslpenqgheiaarqqkGFGAMLSFELDgDEQTLRRFLGGLSL 320
Cdd:PRK08247 240 LIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP----------------GRGGMLSFRLQ-DEEWVNPFLKSLKL 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485721626 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAAN 384
Cdd:PRK08247 303 ITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQVK 366
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
6-383 |
1.14e-119 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 351.82 E-value: 1.14e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGlNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTT 85
Cdd:TIGR01329 2 STLLVNTD-NKNDPYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 86 VfLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLARE 165
Cdd:TIGR01329 81 L-LNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 166 VGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGL 245
Cdd:TIGR01329 160 QNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 246 RTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFElDGDEQTLRRFLGGLSLFTLAE 325
Cdd:TIGR01329 240 KTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE-TGSVALSKRLVEATKLFSITV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:TIGR01329 319 SFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
17-386 |
2.59e-119 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 351.38 E-value: 2.59e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 17 DEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIhlvTTVF--LKPGDLL 94
Cdd:PRK08064 19 DKQTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAI---STAFllLSKGDHV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 95 VAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDN 174
Cdd:PRK08064 96 LISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 175 TFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMEL 254
Cdd:PRK08064 176 TFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEH 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 255 AQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELdGDEQTLRRFLGGLSLFTLAESLGGVESLI 334
Cdd:PRK08064 256 SSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTL-QSEEAVRQFVSHVKLPVFAVSLGAVESIL 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 485721626 335 SHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG 386
Cdd:PRK08064 335 SYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEEP 386
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
7-382 |
6.23e-119 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 349.97 E-value: 6.23e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTV 86
Cdd:PRK06176 5 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 87 FlKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREV 166
Cdd:PRK06176 85 F-QSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDH 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 167 GAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLR 246
Cdd:PRK06176 164 GLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 247 TLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQtLRRFLGGLSLFTLAES 326
Cdd:PRK06176 244 TLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFILGES 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 485721626 327 LGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK06176 323 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
4-383 |
3.52e-118 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 348.65 E-value: 3.52e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 4 KQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNE--------PRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:PRK08249 8 GVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEwydvalgkKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFST 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 76 GMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVD 155
Cdd:PRK08249 88 GMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 156 IAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAkDPDVVTELAWWANNIGVTGGA 235
Cdd:PRK08249 168 IERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCG-SKELMEQVYHYREINGATMDP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 236 FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFL 315
Cdd:PRK08249 247 MSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKRLL 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 316 GGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK08249 327 PKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-383 |
3.95e-115 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 342.01 E-value: 3.95e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKQ---ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAG 69
Cdd:COG2873 1 MTEKKygfETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADlfalkepgNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 70 AVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFD-SLAKRGcYRVLFVDQGDEQALRAALADKPKLVLVESPSN 148
Cdd:COG2873 81 ALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAhTLPRLG-IEVRFVDPDDPEAFEAAIDPNTKAIFGETIGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 149 PLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------------- 212
Cdd:COG2873 160 PALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVdggnfdwaangkfpel 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 213 -AKDP--------DVVTELAW-------WANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLY 276
Cdd:COG2873 240 tEPDPsyhglvytEAFGNAAFitkarvqLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 277 HPSLPENQGHEIAARQ-QKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGI 355
Cdd:COG2873 320 YPGLPSHPYHELAQKYlPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGV 399
|
410 420
....*....|....*....|....*...
gi 485721626 356 SETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:COG2873 400 TPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
1-382 |
4.66e-114 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 336.79 E-value: 4.66e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK07269 3 KDLHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 81 HLVTTVFlkP-GDLLVAPHDCYGGSYRLFDSLAKRGcyRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKI 159
Cdd:PRK07269 83 VLAFSVF--PvGSKVVAVRDLYGGSFRWFNQQEKEG--RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 160 CHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSY 239
Cdd:PRK07269 159 AKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 240 LLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPslpenqgheiaarqqkGFGAMLSFELdGDEQTLRRFLGGLS 319
Cdd:PRK07269 239 LLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT----------------GKGGMISFKV-ADETRIPHILNSLK 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485721626 320 LFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK07269 302 VFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
6-382 |
1.06e-110 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 329.54 E-value: 1.06e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNF----TGFN----EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:TIGR01328 5 ATRAIHAGYPPKDQFGALTPPIYQTSTFVFdsceQGGNrfagQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIA 157
Cdd:TIGR01328 85 GAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDME 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 158 KICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDV-VTELAWWANNIGVTGGAF 236
Cdd:TIGR01328 165 RVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLqQIRMVGIKDMTGSVISPF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 237 DSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLG 316
Cdd:TIGR01328 245 DAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGAKKLLN 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485721626 317 GLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:TIGR01328 325 NLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
6-382 |
1.86e-109 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 326.19 E-value: 1.86e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDdEQYGCVVPPIHLSSTYNFT-------GF-NEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK08133 8 DTLAVRAGQLR-SPFGEHSEALFLTSSFVFEsaaeaaaRFaGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK08133 87 AAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELADIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 158 KICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDpDVVTELAWWANNIGVTGGAFD 237
Cdd:PRK08133 167 ALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSK-ELMEEVFGFLRTAGPTLSPFN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 238 SYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGG 317
Cdd:PRK08133 246 AWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWRVIDA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485721626 318 LSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK08133 326 TRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
6-383 |
2.94e-108 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 323.68 E-value: 2.94e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK07503 11 STRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEygaecfagEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYR-LFDSLAKRGCyRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDI 156
Cdd:PRK07503 91 GAITATLWTLLRPGDEVIVDQTLYGCTFAfLHHGLGEFGV-TVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 157 AKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVV-TELAWWANNIGVTGGA 235
Cdd:PRK07503 170 AAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADrIRLEGLKDMTGAVMSP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 236 FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFL 315
Cdd:PRK07503 250 FDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRRFM 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 316 GGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK07503 330 NALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDAC 397
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
6-379 |
2.30e-107 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 321.01 E-value: 2.30e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK06234 10 ATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEqggrrfagEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK06234 90 GAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIK 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 158 KICHLAREV--GAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDpDVVTELAWWA--NNIGVTG 233
Cdd:PRK06234 170 AISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKE-EFINQVKLFGikDMTGSVI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 234 GAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRR 313
Cdd:PRK06234 249 GPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEGKV 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485721626 314 FLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENG 379
Cdd:PRK06234 329 VMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQA 394
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
4-382 |
2.69e-107 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 320.47 E-value: 2.69e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 4 KQATIAVRSGLNDDeQYGCVVPPIHLSSTYNFTGFNEP--RAHD--YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSA 79
Cdd:PRK08574 2 RRGTDAVRGYRGSD-PYGSLQPPIYLTALFRQEGEAYPsdRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 80 IHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGcYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKI 159
Cdd:PRK08574 81 ISTLFFSLLKAGDRVVLPMEAYGTTLRLLKSLEKFG-VKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 160 CHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSY 239
Cdd:PRK08574 160 AKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 240 LLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAAR--QQKGFGAMLSFELDGDEQTLRRFLGG 317
Cdd:PRK08574 240 LVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRlfGKDLYGGVVSFRVKGGRDAVLKFLRS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485721626 318 LSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK08574 320 LKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
4-377 |
4.74e-99 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 299.05 E-value: 4.74e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 4 KQATIAVRSGLndDEQYGCVVPPIHLSSTYNFTGFNEPRahdYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLV 83
Cdd:PRK06460 2 KDATRTVREDI--DEATGAITTPIYQTTAYHYPEGEKYR---YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 84 TTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLA 163
Cdd:PRK06460 77 ALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 164 REVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVvIAKDPDVVTELAWWANNIGVTGGAFDSYLLLR 243
Cdd:PRK06460 157 KENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGL-AAGYGKLLNVIDQMRRTLGTSLDPHAAYLTLR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 244 GLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTL 323
Cdd:PRK06460 236 GIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIP 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 485721626 324 AESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK06460 316 AQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLD 369
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
7-377 |
1.15e-97 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 295.98 E-value: 1.15e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFT----GFNEPRAHD----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
Cdd:PRK06767 8 TALIHHGYTSEEHKGSLTPPLFQTSTFTFEtaqqGEASFAGVDpsyiYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 79 AIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAK 158
Cdd:PRK06767 88 AISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 159 ICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDS 238
Cdd:PRK06767 168 VIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 239 YLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSlpenqgHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGL 318
Cdd:PRK06767 248 WLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE------GELASRQMKRGGGVISFSIKGGKEETQAFINDL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 485721626 319 SLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK06767 322 HFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLE 380
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
15-381 |
2.91e-96 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 295.01 E-value: 2.91e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 15 NDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVfLKPGDLL 94
Cdd:PLN02509 96 NKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHL-IKNGEEI 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 95 VAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDN 174
Cdd:PLN02509 175 VAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDN 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 175 TFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMEL 254
Cdd:PLN02509 255 SIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEK 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 255 AQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFeLDGDEQTLRRFLGGLSLFTLAESLGGVESLI 334
Cdd:PLN02509 335 QQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLI 413
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 485721626 335 SHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:PLN02509 414 SMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
6-379 |
9.27e-96 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 290.98 E-value: 9.27e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLnDDEQYGCVVPPIHLSSTY----------NFTGfnEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:TIGR01325 1 ATLAVRGGM-LRSGFEETAEALYLTSGYvydsaavaakRFAG--ELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATAS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 76 GMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVD 155
Cdd:TIGR01325 78 GMAAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 156 IAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGA 235
Cdd:TIGR01325 158 IAAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 236 FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLrRFL 315
Cdd:TIGR01325 238 FNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQAAF-KVL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485721626 316 GGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENG 379
Cdd:TIGR01325 317 DAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
21-383 |
5.48e-93 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 285.41 E-value: 5.48e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 21 GCVVPPIHLSSTYNF-------------TGFNEPRAHD-----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHL 82
Cdd:PRK07049 34 GAVKPPVFLTSTFVFrsaedgrdffdyvSGRKEPPAGEgaglvYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 83 VTTVFLKPGDLLVAPHDCYGGSYRLF-DSLAKRGCYRVLFVDQGDEQALRAALAD-----KPKLVLVESPSNPLLRVVDI 156
Cdd:PRK07049 114 TLLAFVRPGDVILHSQPLYGGTETLLaKTFRNFGVGAVGFADGLSEAAIGAAAEAaaakgRVSLILIETPANPTNSLVDV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 157 AKICHLAREVGA------VSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDpDVVTELAWWANNIG 230
Cdd:PRK07049 194 AAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLGRK-ALIRQVRALRSAIG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 231 VTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKL-YHPSL-PENQGHEIAARQQKGFGAMLSFELDGDE 308
Cdd:PRK07049 273 TQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLhYLPFLdPDSAYGAVYKRQCTGAGSTFSFDIKGGQ 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485721626 309 QTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK07049 353 AAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
6-380 |
5.10e-91 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 280.01 E-value: 5.10e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFT---------GFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTG 76
Cdd:TIGR01326 3 ETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDstehaaalfGLQEP-GNIYSRLMNPTTDVLEQRIAALEGGVAALAVASG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 77 MSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDI 156
Cdd:TIGR01326 82 QAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 157 AKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------AKDPDVVT------- 220
Cdd:TIGR01326 162 EAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwnnGRFPLFTTpdpsyhg 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 221 --------ELAW-------WANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQG 285
Cdd:TIGR01326 242 lvftetlgNPAFilkarvqLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPH 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 286 HEIAAR-QQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:TIGR01326 322 HALAKKyLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLSV 401
|
410
....*....|....*.
gi 485721626 365 GIEDGEDLIADLENGF 380
Cdd:TIGR01326 402 GIENIDDIIADLEQAL 417
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-386 |
4.34e-86 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 267.76 E-value: 4.34e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTG-------FNEPRA-HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
Cdd:PRK08134 11 TLALHAGAAPDPATGARAVPIHLTTSFVFRDsdhaaalFNLERAgHVYSRISNPTVAVLEERVAALEGGVGAIATASGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 79 AIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAK 158
Cdd:PRK08134 91 ALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 159 ICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI----------AKDPDVVTELAWWANN 228
Cdd:PRK08134 171 VAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVdggrfdweasGKFPELTEPYAGFHGM 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 229 I---GVTGGAF-------------------DSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGH 286
Cdd:PRK08134 251 VfaeESTVAAFllrarreglrdfgaclspmNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDH 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 287 EIAAR-QQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTG 365
Cdd:PRK08134 331 ALAKRlLPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIG 410
|
410 420
....*....|....*....|.
gi 485721626 366 IEDGEDLIADLENGFRAANKG 386
Cdd:PRK08134 411 LEDADDLIDDLKRALKAAEKA 431
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
6-383 |
2.79e-85 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 263.40 E-value: 2.79e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGaGAVLTNTGMSAIHLVTT 85
Cdd:PRK07582 5 GTRSVHAGGPEAVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAITAVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 86 VFLKPGDLLVAPHDCYGGSYRLF-DSLAKRGCyRVLFVDQGDeqaLRAALADKPKLVLVESPSNPLLRVVDIAKICHLAR 164
Cdd:PRK07582 84 ALLRPGDTVVVPADGYYQVRALArEYLAPLGV-TVREAPTAG---MAEAALAGADLVLAETPSNPGLDVCDLAALAAAAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 165 EVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRG 244
Cdd:PRK07582 160 AAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 245 LRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELdGDEQTLRRFLGGLSLFTLA 324
Cdd:PRK07582 240 LGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVVAA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 485721626 325 ESLGGVESlishaatmthagmAPEARAAAG--ISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK07582 319 TSFGGVHT-------------SADRRARWGdaVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
7-382 |
9.95e-84 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 260.22 E-value: 9.95e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHD--------YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
Cdd:PRK06434 11 TRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDstrgmpyiYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 79 AIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAAlADKPKLVLVESPSNPLLRVVDIAK 158
Cdd:PRK06434 91 AITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLDFD-PSNYDLIYAESITNPTLKVPDIKN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 159 ICHLAREvgAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDS 238
Cdd:PRK06434 170 VSSFCHE--NDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 239 YLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLpenqghEIAARQQKGFGAMLSFELDGDEQtLRRFLGGL 318
Cdd:PRK06434 248 YLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSMED-VHKFIRNL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485721626 319 SLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK06434 321 EIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
5-377 |
2.32e-83 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 259.67 E-value: 2.32e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 5 QATIAVRSGLnDDEQYGCVVPPIHLSSTY----------NFTGfnEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTN 74
Cdd:PRK07810 16 QATIGVRGGL-LRSGFEETAEALYLTSGYvyesaaaaeaAFTG--ELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 75 TGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVV 154
Cdd:PRK07810 93 SGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 155 DIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGG 234
Cdd:PRK07810 173 DIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALS 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 235 AFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRR- 313
Cdd:PRK07810 253 AFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAAKKr 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485721626 314 ---FLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK07810 333 afeVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLD 399
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-385 |
1.83e-80 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 253.52 E-value: 1.83e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFT---------GFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK07812 16 TKQIHAGQTPDPATNARALPIYQTTSYTFDdtdhaaalfGLAEP-GNIYTRIMNPTQDVVEQRIAALEGGVAALLLASGQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFD-SLAKRGCyRVLFV-DQGDEQALRAALADKPKLVLVESPSNPLLRVVD 155
Cdd:PRK07812 95 AAETFAILNLAGAGDHIVSSPRLYGGTYNLFHyTLPKLGI-EVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 156 IAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIA--------------KDPD---- 217
Cdd:PRK07812 174 IPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDggtfdwtqgrfpgfTTPDpsyh 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 218 --VVTELA----------WWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQG 285
Cdd:PRK07812 254 gvVFAELGppayalkarvQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPW 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 286 HEIAAR-QQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:PRK07812 334 YERAKRlAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAV 413
|
410 420
....*....|....*....|.
gi 485721626 365 GIEDGEDLIADLENGFRAANK 385
Cdd:PRK07812 414 GIEGIDDILADLEAGFAAAKA 434
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
46-383 |
1.13e-76 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 242.35 E-value: 1.13e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 46 YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQG 125
Cdd:PRK07504 59 YSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 126 DEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSD 205
Cdd:PRK07504 139 DLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 206 VVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQG 285
Cdd:PRK07504 219 CLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQ 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 286 HEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTG 365
Cdd:PRK07504 299 ADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAG 378
|
330
....*....|....*...
gi 485721626 366 IEDGEDLIADLENGFRAA 383
Cdd:PRK07504 379 LEDTDDLIEDLAAALKKV 396
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
16-385 |
3.66e-76 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 240.75 E-value: 3.66e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 16 DDEQYGCVVPPIHLSSTYNFTGFNE------PRAHD--YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVF 87
Cdd:PRK05968 19 EGNAFDAVVPPIFQTSLFTFDSYDEmedvyaGEKVRpiYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 88 LKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKpKLVLVESPSNPLLRVVDIAKICHLAREVG 167
Cdd:PRK05968 99 VEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALPGA-KLLYLESPTSWVFELQDVAALAALAKRHG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 168 AVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRT 247
Cdd:PRK05968 178 VVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYPYLGAKLSPFEAWLLLRGLRT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 248 LVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLpenQGHEIAArqQKGFGAMLSFELDgDEQTLRRFLGGLSLFTLAESL 327
Cdd:PRK05968 258 LPLRMKAHEASALEIARRLKAHPVVERVCHPAL---ANHPPAG--LSGTSGLFSFIFR-EGIDVRAFADALKLFRLGVSW 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 328 GGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANK 385
Cdd:PRK05968 332 GGHESLVVPAEVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALAAASR 389
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
19-383 |
4.80e-75 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 238.05 E-value: 4.80e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 19 QYGCVVPPIHLSSTYnftGFNEPR-----------AHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVF 87
Cdd:PRK05939 6 EHGAVHKPIHTSVTY---GYEDARdlidvfqgkkpGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 88 LKPGDLLVAPHDCYGGSYRLFDSLAKRGCyRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVG 167
Cdd:PRK05939 83 LRAGDHLVSSQFLFGNTNSLFGTLRGLGV-EVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 168 AVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVV-------------IAKDPDVVTELAWWANNI----- 229
Cdd:PRK05939 162 LLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVtdtglfdwsaypnIFPAYRKGDPQQWGLTQIrkkgl 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 230 ---GVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDG 306
Cdd:PRK05939 242 rdmGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELAD 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485721626 307 DEQTLrRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK05939 322 GIDCF-DFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
7-385 |
2.32e-72 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 232.43 E-value: 2.32e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFT---------GFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK08248 11 TLAIHAGQEIDPTTGSRAVPIYQTTSYGFRdsehaanlfSLKEF-GNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK08248 90 AAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 158 KICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI-----------------AKDP---- 216
Cdd:PRK08248 170 AVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpgltEPDPsyhg 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 217 ----DVVTELAW-------WANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQG 285
Cdd:PRK08248 250 lvytDAVGEAAYitkarvqLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 286 HEIAARQ-QKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:PRK08248 330 YELAKKYlPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSV 409
|
410 420
....*....|....*....|.
gi 485721626 365 GIEDGEDLIADLENGFRAANK 385
Cdd:PRK08248 410 GTEAIDDILDDLRQAIRQSQT 430
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-383 |
9.09e-70 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 225.36 E-value: 9.09e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK05994 9 ATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASlfglqafgNIYTRITNPTNAVLEERVAALEGGTAALAVASGH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK05994 89 AAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDIA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 158 KICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI-------AKDPD------------- 217
Cdd:PRK05994 169 AIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwSKSGKypmlseprpeyhg 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 218 -VVTE------LAWWANNIGVT--GGA---FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQG 285
Cdd:PRK05994 249 lVLHEtfgnfaFAIAARVLGLRdlGPAispFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPY 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 286 HEIAAR-QQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:PRK05994 329 HALAQKySPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSI 408
|
410
....*....|....*....
gi 485721626 365 GIEDGEDLIADLENGFRAA 383
Cdd:PRK05994 409 GIEDVDDIIADLEQALAKA 427
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
4-383 |
5.48e-66 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 215.54 E-value: 5.48e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 4 KQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:PRK06084 2 KLETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQhgadlfdlKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 76 GMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVD 155
Cdd:PRK06084 82 GMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 156 IAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVV----------------IAKDPDV- 218
Cdd:PRK06084 162 IQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVvdsgkfpwaehkerfaLLNTPDPs 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 219 -----VTE----LAWWAN-------NIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPE 282
Cdd:PRK06084 242 yhgvtYTEafgpAAFIGRcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 283 NQGHEIAARQQKGF-GAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLR 361
Cdd:PRK06084 322 HPEHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVR 401
|
410 420
....*....|....*....|..
gi 485721626 362 ISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK06084 402 LSIGIEHIDDIIADLAQALDAS 423
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
7-383 |
8.03e-65 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 211.27 E-value: 8.03e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHD----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHL 82
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDSHAAQRRAKgeltYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 83 VTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHL 162
Cdd:TIGR01324 81 SILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 163 AREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDpDVVTELAWWANNIGVTGGAFDSYLLL 242
Cdd:TIGR01324 161 ARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANA-RTWDQLREHSYLMGQMVDADDAYTTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 243 RGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQ-TLRRFLGGLSLF 321
Cdd:TIGR01324 240 RGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQkQVHAFLDHLQLF 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485721626 322 TLAESLGGVESLishaATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:TIGR01324 320 GLGYSWGGYESL----ALCNQPELGHRPNIKRNLEGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
3-384 |
8.24e-64 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 208.89 E-value: 8.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 3 RKQATIAVR---SGLNDDEQYGCVVPPIHLSSTYNF----TGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:PRK05967 8 TEKAGINTRlahDGNDPGDYHGFVNPPVVHASTVLFpdaeTMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 76 GMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVD 155
Cdd:PRK05967 88 GLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 156 IAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAkdpdvvTELAWWA-----NNIG 230
Cdd:PRK05967 168 IPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSA------NEKCWPQlleahGTLG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 231 VTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQT 310
Cdd:PRK05967 242 LCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPEK 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 311 LRR----FLGGLSLFTLAESLGGVESLishaatMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAAN 384
Cdd:PRK05967 322 GKAkahaFLDALEIFGLGYSWGGYESL------ALHVKLGDRTVAKAPYAGPVIRLQIGLEDVPDLKADLERGFAAAS 393
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
1-385 |
4.62e-59 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 196.49 E-value: 4.62e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPR---------AHDYSRRGNPTRDVVQRALAELEGGAGAV 71
Cdd:PRK09028 1 MSEKKATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEMRhaaknrangEMFYGRRGTPTHFAFQAAIVELEGGAGTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 72 LTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLL 151
Cdd:PRK09028 81 LYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 152 RVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDP--DVVTELAWWannI 229
Cdd:PRK09028 161 EVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKhwDQLREHSYL---M 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 230 GVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFEL-DGDE 308
Cdd:PRK09028 238 GQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLkQGDP 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 485721626 309 QTLRRFLGGLSLFTLAESLGGVESLIshaatMTHAGMApEARAAA--GISETLLRISTGIEDGEDLIADLENGFRAANK 385
Cdd:PRK09028 318 KAVTALVEGMQHFKMGFSWGGFESLI-----LGVFGIN-KLRTATnwDFSKPLIRLHIGLEDVDDLIADLEAGFERYNA 390
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-385 |
2.10e-57 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 192.25 E-value: 2.10e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHD--------YSRRGNPTRDVVQRALAELEGGAGAVL 72
Cdd:PRK07050 6 PKRALQTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRALDwrqdvqwrYGLHATPTSLALAQRLAEIEGGRHALL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 73 TNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLR 152
Cdd:PRK07050 86 QPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTME 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 153 VVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVT 232
Cdd:PRK07050 166 VPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 233 GGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDG--DEQT 310
Cdd:PRK07050 246 VSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDErySPAQ 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485721626 311 LRRFLGGLSLFTLAESLGGVESLishAATMTHAGMAPEARAAAGiseTLLRISTGIEDGEDLIADLENGFRAANK 385
Cdd:PRK07050 326 VDAFVEALELFAIGWSWGGACSL---AMPYDVASMRTAKWPHRG---TLVRLYIGLEDEADLIADLEQALEAALA 394
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
6-382 |
3.26e-56 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 190.47 E-value: 3.26e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTG-------FN-EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK05613 15 ETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSaehakqrFAlEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 78 SAIhlvTTVFL---KPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDE-QALRAALADKPKLVLVESPSNPLLRV 153
Cdd:PRK05613 95 AAE---TAAILnlaGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDpESWQAAVQPNTKAFFGETFANPQADV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 154 VDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------AKD-----PDVV 219
Cdd:PRK05613 172 LDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtvERDgkpvfPYFV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 220 T-----------ELAWWA----------NNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHP 278
Cdd:PRK05613 252 TpdpayhglkyaDLGAPAfglkaragllRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 279 SLPENQGHeiAARQQKGF---GAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGI 355
Cdd:PRK05613 332 GLKDSPWY--ATKEKLGLkytGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGI 409
|
410 420
....*....|....*....|....*..
gi 485721626 356 SETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK05613 410 TQATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
46-366 |
1.20e-52 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 180.35 E-value: 1.20e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 46 YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGC-YRVLFVDQ 124
Cdd:PLN02242 70 YSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRKCnITTTFVDI 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 125 GDEQALRAALAD-KPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFlSPALQNPLALGADLVLHSCTKYLNGH 203
Cdd:PLN02242 150 TDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVVHSISKFISGG 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 204 SDVVAGVVIAKdPDVVTELAWWANN----IGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLvkKLYHPS 279
Cdd:PLN02242 229 ADIIAGAVCGP-AELVNSMMDLHHGalmlLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKELGL--KVIYPG 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 280 LPENQGHEIAARQQK---GFGAMLSFELDGDE--QTLRRFLGGLSLFTL-AESLGGVESLISHAATMTHAGMAPEARAAA 353
Cdd:PLN02242 306 LEDHPQHALLKSMANkgyGFGGLLCLDMDTEEraNRLMRYLQNSTQFGFmAVSLGYYETLMSCSGSSTSSELDPEEKAAA 385
|
330
....*....|...
gi 485721626 354 GISETLLRISTGI 366
Cdd:PLN02242 386 GISPGLVRMSVGY 398
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
24-377 |
3.04e-51 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 177.17 E-value: 3.04e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 24 VPPIHLSSTYNFTG-------FN-EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLV 95
Cdd:PRK06702 25 VLPLYQSTTYKYDTsddlaalFNlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNICSSGDHLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 96 APHDCYGGSYRLFD-SLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDN 174
Cdd:PRK06702 105 CSSTVYGGTFNLFGvSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDN 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 175 TFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAK--------------DPDVVTELAWWANNIGVTG------- 233
Cdd:PRK06702 185 TLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGgnfdwtngkypelvEPDPSYHGVSYVQNFGAAAyivkarv 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 234 ----------GAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQ-QKGFGAMLSF 302
Cdd:PRK06702 265 qllrdygncmSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYlKKGASGVLTF 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485721626 303 ELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK06702 345 GIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLE 419
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
1-381 |
4.23e-51 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 175.66 E-value: 4.23e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 1 MTRKQ-ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEP------RAHD---YSRRGNPTRDVVQRALAELEGGAGA 70
Cdd:PRK08114 1 MTDKKlDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKkhatrnRANGelfYGRRGTLTHFSLQEAMCELEGGAGC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 71 VLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALADKPKLVLVESPSNPL 150
Cdd:PRK08114 81 ALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 151 LRVVDIAKICHLAREVG--AVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDP--DVVTELAWWa 226
Cdd:PRK08114 161 MEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARcwEQLRENSYL- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 227 nnIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDG 306
Cdd:PRK08114 240 --MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKK 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485721626 307 --DEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEarAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:PRK08114 318 klTDEQLANYLDNFSLFSMAYSWGGFESLILANQPEEIAAIRPA--GEVDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
71-279 |
3.95e-09 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 57.74 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 71 VLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFdSLAKRGCYRVLFVDQG----DEQALRAALADKPKLVLVESP 146
Cdd:cd00609 63 VVTNGAQEALSLLLRALLNPGDEVLVPDPTYPGYEAAA-RLAGAEVVPVPLDEEGgfllDLELLEAAKTPKTKLLYLNNP 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 147 SNPLLRVVD---IAKICHLAREVGAVSVVDNT---FLSPALQNPLALGAD-----LVLHSCTKYLNghsdvVA----GVV 211
Cdd:cd00609 142 NNPTGAVLSeeeLEELAELAKKHGILIISDEAyaeLVYDGEPPPALALLDayervIVLRSFSKTFG-----LPglriGYL 216
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485721626 212 IAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRT----LVPRMELAQRNAQAIVKYLQTQPLVKKLYHPS 279
Cdd:cd00609 217 IAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDDgeehLEELRERYRRRRDALLEALKELGPLVVVKPSG 288
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
58-214 |
6.01e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 54.70 E-value: 6.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 58 QRALAELEGGA--GAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKrgcYRVLFVDQGDEQAL----- 130
Cdd:cd01494 6 EEKLARLLQPGndKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELAG---AKPVPVPVDDAGYGgldva 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 131 ---RAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLAL----GADLVLHSCTKYLNGh 203
Cdd:cd01494 83 ileELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLipegGADVVTFSLHKNLGG- 161
|
170
....*....|.
gi 485721626 204 sdVVAGVVIAK 214
Cdd:cd01494 162 --EGGGVVIVK 170
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
61-223 |
3.49e-08 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 54.76 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 61 LAELE-GGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDcyggSYRLFDSLAKRGCYRVLFVDQGDEQ--------ALR 131
Cdd:PRK06225 76 LKDLGlDDDEALITAGATESLYLVMRAFLSPGDNAVTPDP----GYLIIDNFASRFGAEVIEVPIYSEEcnykltpeLVK 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 132 AALADKPKLVLVESPSNPL---LRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGAD----LVLHSCTKYLnGHS 204
Cdd:PRK06225 152 ENMDENTRLIYLIDPLNPLgssYTEEEIKEFAEIARDNDAFLLHDCTYRDFAREHTLAAEYApehtVTSYSFSKIF-GMA 230
|
170
....*....|....*....
gi 485721626 205 DVVAGVVIAKdPDVVTELA 223
Cdd:PRK06225 231 GLRIGAVVAT-PDLIEVVK 248
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
60-173 |
7.62e-06 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 47.30 E-value: 7.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 60 ALAELEGG--------AGAVLTNTGMSAIHLV-TTVFLKPGDLLVAPHDCYGGSYRLFdSLAKRGCYRVLFVD----QGD 126
Cdd:pfam00155 47 ALAKFLGRspvlkldrEAAVVFGSGAGANIEAlIFLLANPGDAILVPAPTYASYIRIA-RLAGGEVVRYPLYDsndfHLD 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 485721626 127 EQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLA---REVGAVSVVD 173
Cdd:pfam00155 126 FDALEAALKEKPKVVLHTSPHNPTGTVATLEELEKLLdlaKEHNILLLVD 175
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
71-206 |
2.16e-05 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 46.28 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 71 VLTNTGMSAIHLVT----TVFLKPGD---LLVAPHDCYGGSYRLFdsLAKRGCyrVL-FVD-----QGDEQALRAALADK 137
Cdd:PLN02855 98 VFTRNATEAINLVAytwgLANLKPGDeviLSVAEHHSNIVPWQLV--AQKTGA--VLkFVGltpdeVLDVEQLKELLSEK 173
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 138 PKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQ-NPLALGADLVLHSCTK--------YLNGHSDV 206
Cdd:PLN02855 174 TKLVATHHVSNVLGSILPVEDIVHWAHAVGAKVLVDACQSVPHMPvDVQTLGADFLVASSHKmcgptgigFLWGKSDL 251
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
71-158 |
2.59e-05 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 45.89 E-value: 2.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 71 VLTNTGMSAIHLVTTVFLKPGD--LLVAPH-DCY-------GGSYRLFDSLAKRGcYRVlfvdqgDEQALRAALADKPKL 140
Cdd:COG0436 94 LVTNGAKEALALALLALLNPGDevLVPDPGyPSYraavrlaGGKPVPVPLDEENG-FLP------DPEALEAAITPRTKA 166
|
90 100
....*....|....*....|....*..
gi 485721626 141 VLVESPSNP---------LLRVVDIAK 158
Cdd:COG0436 167 IVLNSPNNPtgavysreeLEALAELAR 193
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
126-173 |
1.86e-04 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 43.22 E-value: 1.86e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 485721626 126 DEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVD 173
Cdd:cd06453 128 DLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVD 175
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
111-173 |
2.06e-04 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 43.00 E-value: 2.06e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485721626 111 LAKRGCYRVLFV---DQG--DEQALRAALADKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVD 173
Cdd:pfam00266 108 LAKRTGARVRVLpldEDGllDLDELEKLITPKTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVD 175
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
88-173 |
2.10e-04 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 43.20 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 88 LKPGD-LLVAPHDcYGGSYRLFDSLAKRGCYRVLFV---DQG--DEQALRAALADKPKLVLVESPSNPLLRVVDIAKICH 161
Cdd:COG0520 100 LKPGDeILITEME-HHSNIVPWQELAERTGAEVRVIpldEDGelDLEALEALLTPRTKLVAVTHVSNVTGTVNPVKEIAA 178
|
90
....*....|..
gi 485721626 162 LAREVGAVSVVD 173
Cdd:COG0520 179 LAHAHGALVLVD 190
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
71-149 |
6.46e-04 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 41.65 E-value: 6.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 71 VLTNTGMS-AIHLVTTVFLKPGD--LLVAPhdcYGGSYRLFDSLAkrGCyRVLFVDQGDEQ-------ALRAALADKPKL 140
Cdd:PRK05764 94 VIVTTGAKqALYNAFMALLDPGDevIIPAP---YWVSYPEMVKLA--GG-VPVFVPTGEENgfkltveQLEAAITPKTKA 167
|
....*....
gi 485721626 141 VLVESPSNP 149
Cdd:PRK05764 168 LILNSPSNP 176
|
|
| PRK07337 |
PRK07337 |
pyridoxal phosphate-dependent aminotransferase; |
71-201 |
2.38e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180937 Cd Length: 388 Bit Score: 39.66 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 71 VLTNTGMSAIHLVTTVFLKPGDLLVAPHDCY----------GGSYRLFDS-LAKRgcyrvlFvdQGDEQALRAALADKPK 139
Cdd:PRK07337 94 VVTAGASAALLLACLALVERGDEVLMPDPSYpcnrhfvaaaEGRPVLVPSgPAER------F--QLTAADVEAAWGERTR 165
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485721626 140 LVLVESPSNPL---LRVVDIAKICHLAREVGAVSVVDNTFLS----PALQNPLALGADLV-LHSCTKYLN 201
Cdd:PRK07337 166 GVLLASPSNPTgtsIAPDELRRIVEAVRARGGFTIVDEIYQGlsydAAPVSALSLGDDVItINSFSKYFN 235
|
|
| |
