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Conserved domains on  [gi|485877211|ref|WP_001473354|]
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IS3 family transposase [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 super family cl41295
IS3 family transposase;
121-504 2.22e-113

IS3 family transposase;


The actual alignment was detected with superfamily member NF033516:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 339.93  E-value: 2.22e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 121 EVKRQAVMALSTRQVSASEIARRIGVSRAVLYKWKDEIIGNsayqtMRKHNEPSLEAERDALREEVARLNQEIRRRQMEL 200
Cdd:NF033516   1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGG-----GEAADAGRLKELLTPEEEENRRLKRELAELRLEN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 201 DILKKAEEiikkdpgisisHLNNREKTKIADALRQTYPLTELLHVLSLARSSYFYH--RAALKAGDKYATIRTMLTDIFN 278
Cdd:NF033516  76 EILKKARK-----------LLRPAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWrkRPPSRRAPDDAELRARIREIFE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 279 SNYQCYGYRRLHAMLRHEGVRLSEKVVRRLMVEEQLVVSRNR-RRRYSSYCGEIGPAPDNLIARDFKAEQPNQKWLTDIT 357
Cdd:NF033516 145 ESRGRYGYRRITALLRREGIRVNHKRVYRLMRELGLLARRRRkRRPYTTDSGHVHPVAPNLLNRQFTATRPNQVWVTDIT 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 358 EFQLPAGKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLDSAVKTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIRS 437
Cdd:NF033516 225 YIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHSDNGSQYTSKAYREWLKEHGITQS 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485877211 438 MSRKGCSPDNAACEGFFGRLKTEMYYGRKWSgiTPEKFMQQVDAYIRWYNERRIKLSLGAVSPKMYR 504
Cdd:NF033516 305 MSRPGNCWDNAVAESFFGTLKRECLYRRRFR--TLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-67 2.59e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member pfam01527:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 75  Bit Score: 39.64  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485877211    2 FTEEEKIRAIELYFKYGKKLAPVVRELGYpSKRNLRRWIRSWEAGGGVKESirhKHRYSDEQKQVA 67
Cdd:pfam01527   7 FSEEFKLRAVKEVLEPGRTVKEVARRHGV-SPNTLYQWRRQYEGGMGASPA---RPRLTALEEENR 68
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
121-504 2.22e-113

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 339.93  E-value: 2.22e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 121 EVKRQAVMALSTRQVSASEIARRIGVSRAVLYKWKDEIIGNsayqtMRKHNEPSLEAERDALREEVARLNQEIRRRQMEL 200
Cdd:NF033516   1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGG-----GEAADAGRLKELLTPEEEENRRLKRELAELRLEN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 201 DILKKAEEiikkdpgisisHLNNREKTKIADALRQTYPLTELLHVLSLARSSYFYH--RAALKAGDKYATIRTMLTDIFN 278
Cdd:NF033516  76 EILKKARK-----------LLRPAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWrkRPPSRRAPDDAELRARIREIFE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 279 SNYQCYGYRRLHAMLRHEGVRLSEKVVRRLMVEEQLVVSRNR-RRRYSSYCGEIGPAPDNLIARDFKAEQPNQKWLTDIT 357
Cdd:NF033516 145 ESRGRYGYRRITALLRREGIRVNHKRVYRLMRELGLLARRRRkRRPYTTDSGHVHPVAPNLLNRQFTATRPNQVWVTDIT 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 358 EFQLPAGKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLDSAVKTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIRS 437
Cdd:NF033516 225 YIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHSDNGSQYTSKAYREWLKEHGITQS 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485877211 438 MSRKGCSPDNAACEGFFGRLKTEMYYGRKWSgiTPEKFMQQVDAYIRWYNERRIKLSLGAVSPKMYR 504
Cdd:NF033516 305 MSRPGNCWDNAVAESFFGTLKRECLYRRRFR--TLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
197-506 1.83e-84

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 263.55  E-value: 1.83e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 197 QMELDILKKAEEIIKKDPGISISHLNNREKTKIADALRQTYPLTELLHVLSLARSSYFYHRAALKAGDKYATIRTMLTDI 276
Cdd:COG2801    1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAELLERIKEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 277 FNSNYqCYGYRRLHAMLRHEGVRLSEKVVRRLMVEEQLVVSRNRRRRYSSYCGEIGPAPDNLIardFKAEQPNQKWLTDI 356
Cdd:COG2801   81 FAESP-RYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGPIAPNLL---FTATAPNQVWVTDI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 357 TEFQLPAGKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLDSAVKTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIR 436
Cdd:COG2801  157 TYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPPKPLILHSDNGSQYTSKAYQELLKKLGITQ 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 437 SMSRKGCSPDNAACEGFFGRLKTEMYYGRKWSgiTPEKFMQQVDAYIRWYNERRIKLSLGAVSPKMYRQQ 506
Cdd:COG2801  237 SMSRPGNPQDNAFIESFFGTLKYELLYRRRFE--SLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQ 304
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 246-500 6.60e-45

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 159.26  E-value: 6.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 246 LSLARSSYFYHRAALKAGDK-------YATIRTMLTDIFNSNYQCYGYRRLHAMLRHEGVRLSEKVVRRLMVEEQLVVSR 318
Cdd:PHA02517   1 LGIAPSTYYRCQQQRHHPDKrraraqhDDWLKSEILRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 319 NRRRRYSSYCGEIGPAPdNLIARDFKAEQPNQKWLTDITEFQLPAGKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLD 398
Cdd:PHA02517  81 RGKKVRTTISRKAVAAP-DRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 399 SAVKTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIRSMSRKGCSPDNAACEGFFGRLKTEMYYGRKWsgITPEKFMQQ 478
Cdd:PHA02517 160 QALWARGRPGGLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSW--KNREEVELA 237

                        250       260
                 ....*....|....*....|..
gi 485877211 479 VDAYIRWYNERRIKLSLGAVSP 500
Cdd:PHA02517 238 TLEWVAWYNNRRLHERLGYTPP 259
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 348-444 8.72e-19

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 8.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211  348 PNQKWLTDITEFQLPA--GKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLDSAVKTLNaGERPVIHSDRGGHYRWPGW 425
Cdd:pfam00665   1 PNQLWQGDFTYIRIPGggGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRG-GVPLIIHSDNGSEYTSKAF 79

                          90
                  ....*....|....*....
gi 485877211  426 LERVNAAGLIRSMSRKGCS 444
Cdd:pfam00665  80 REFLKDLGIKPSFSRPGNP 98
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 2-67 2.59e-04

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 39.64  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485877211    2 FTEEEKIRAIELYFKYGKKLAPVVRELGYpSKRNLRRWIRSWEAGGGVKESirhKHRYSDEQKQVA 67
Cdd:pfam01527   7 FSEEFKLRAVKEVLEPGRTVKEVARRHGV-SPNTLYQWRRQYEGGMGASPA---RPRLTALEEENR 68
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
2-67 2.33e-03

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 37.21  E-value: 2.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485877211   2 FTEEEKIRAIELYFKYGKKLAPVVRELGYPSKRnLRRWIRSWEAGGGvkESIRHKHRYSDEQKQVA 67
Cdd:COG2963    8 YSPEFKAEAVRLVLEGGASVAEVARELGISPST-LYRWVRQYREGGL--GGFPGDGRTTPEQAEIR 70
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
121-504 2.22e-113

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 339.93  E-value: 2.22e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 121 EVKRQAVMALSTRQVSASEIARRIGVSRAVLYKWKDEIIGNsayqtMRKHNEPSLEAERDALREEVARLNQEIRRRQMEL 200
Cdd:NF033516   1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGG-----GEAADAGRLKELLTPEEEENRRLKRELAELRLEN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 201 DILKKAEEiikkdpgisisHLNNREKTKIADALRQTYPLTELLHVLSLARSSYFYH--RAALKAGDKYATIRTMLTDIFN 278
Cdd:NF033516  76 EILKKARK-----------LLRPAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWrkRPPSRRAPDDAELRARIREIFE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 279 SNYQCYGYRRLHAMLRHEGVRLSEKVVRRLMVEEQLVVSRNR-RRRYSSYCGEIGPAPDNLIARDFKAEQPNQKWLTDIT 357
Cdd:NF033516 145 ESRGRYGYRRITALLRREGIRVNHKRVYRLMRELGLLARRRRkRRPYTTDSGHVHPVAPNLLNRQFTATRPNQVWVTDIT 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 358 EFQLPAGKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLDSAVKTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIRS 437
Cdd:NF033516 225 YIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVLDALEMAIEWRGKPEGLILHSDNGSQYTSKAYREWLKEHGITQS 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485877211 438 MSRKGCSPDNAACEGFFGRLKTEMYYGRKWSgiTPEKFMQQVDAYIRWYNERRIKLSLGAVSPKMYR 504
Cdd:NF033516 305 MSRPGNCWDNAVAESFFGTLKRECLYRRRFR--TLEEARQAIEEYIEFYNHERPHSSLGYLTPAEFE 369
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
197-506 1.83e-84

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 263.55  E-value: 1.83e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 197 QMELDILKKAEEIIKKDPGISISHLNNREKTKIADALRQTYPLTELLHVLSLARSSYFYHRAALKAGDKYATIRTMLTDI 276
Cdd:COG2801    1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAELLERIKEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 277 FNSNYqCYGYRRLHAMLRHEGVRLSEKVVRRLMVEEQLVVSRNRRRRYSSYCGEIGPAPDNLIardFKAEQPNQKWLTDI 356
Cdd:COG2801   81 FAESP-RYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGPIAPNLL---FTATAPNQVWVTDI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 357 TEFQLPAGKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLDSAVKTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIR 436
Cdd:COG2801  157 TYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPPKPLILHSDNGSQYTSKAYQELLKKLGITQ 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 437 SMSRKGCSPDNAACEGFFGRLKTEMYYGRKWSgiTPEKFMQQVDAYIRWYNERRIKLSLGAVSPKMYRQQ 506
Cdd:COG2801  237 SMSRPGNPQDNAFIESFFGTLKYELLYRRRFE--SLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQ 304
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 246-500 6.60e-45

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 159.26  E-value: 6.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 246 LSLARSSYFYHRAALKAGDK-------YATIRTMLTDIFNSNYQCYGYRRLHAMLRHEGVRLSEKVVRRLMVEEQLVVSR 318
Cdd:PHA02517   1 LGIAPSTYYRCQQQRHHPDKrraraqhDDWLKSEILRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 319 NRRRRYSSYCGEIGPAPdNLIARDFKAEQPNQKWLTDITEFQLPAGKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLD 398
Cdd:PHA02517  81 RGKKVRTTISRKAVAAP-DRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 399 SAVKTLNAGERPVIHSDRGGHYRWPGWLERVNAAGLIRSMSRKGCSPDNAACEGFFGRLKTEMYYGRKWsgITPEKFMQQ 478
Cdd:PHA02517 160 QALWARGRPGGLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSW--KNREEVELA 237

                        250       260
                 ....*....|....*....|..
gi 485877211 479 VDAYIRWYNERRIKLSLGAVSP 500
Cdd:PHA02517 238 TLEWVAWYNNRRLHERLGYTPP 259
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 348-444 8.72e-19

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 8.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211  348 PNQKWLTDITEFQLPA--GKVWLSPVVDCFDGKVVSWSLSTRPDAELVNTMLDSAVKTLNaGERPVIHSDRGGHYRWPGW 425
Cdd:pfam00665   1 PNQLWQGDFTYIRIPGggGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRG-GVPLIIHSDNGSEYTSKAF 79

                          90
                  ....*....|....*....
gi 485877211  426 LERVNAAGLIRSMSRKGCS 444
Cdd:pfam00665  80 REFLKDLGIKPSFSRPGNP 98
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
102-210 1.04e-12

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 63.79  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 102 PDRRRIFTskanpvapfePEVKRQAVMALSTRQVSASEIARRIGVSRAVLYKWKDEiignsaYQTMRKHNEPSlEAERDA 181
Cdd:COG2963    2 SKKRRRYS----------PEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQ------YREGGLGGFPG-DGRTTP 64

                         90       100
                 ....*....|....*....|....*....
gi 485877211 182 LREEVARLNQEIRRRQMELDILKKAEEII 210
Cdd:COG2963   65 EQAEIRRLRKELRRLEMENDILKKAAALL 93
rve_2 pfam13333
Integrase core domain;
451-506 1.45e-09

Integrase core domain;


Pssm-ID: 372570 [Multi-domain]  Cd Length: 52  Bit Score: 53.80  E-value: 1.45e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 485877211  451 EGFFGRLKTEMYYGRKWsgITPEKFMQQVDAYIRWYNERRIKlslgAVSPKMYRQQ 506
Cdd:pfam13333   1 ESFFGSLKTEMVYGEHF--KTLEELELAIFDYIEWYNNKRLK----GLSPVQYRNQ 50
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 276-316 1.59e-07

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 47.95  E-value: 1.59e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 485877211  276 IFNSNYQCYGYRRLHAMLRHEG-VRLSEKVVRRLMVEEQLVV 316
Cdd:pfam13276  13 IFEESRGTYGYRRITAELRREGgIRVNRKRVARLMRELGLRA 54
rve_3 pfam13683
Integrase core domain;
437-500 2.31e-05

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 42.20  E-value: 2.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485877211  437 SMSRKGCSPDNAACEGFFGRLKTEMYYGRKWSGItpEKFMQQVDAYIRWYNERRIKLSLGAVSP 500
Cdd:pfam13683   6 SYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSL--AEARALLAAWREDYNTERPHSSLGYRTP 67
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 2-67 2.59e-04

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 39.64  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485877211    2 FTEEEKIRAIELYFKYGKKLAPVVRELGYpSKRNLRRWIRSWEAGGGVKESirhKHRYSDEQKQVA 67
Cdd:pfam01527   7 FSEEFKLRAVKEVLEPGRTVKEVARRHGV-SPNTLYQWRRQYEGGMGASPA---RPRLTALEEENR 68
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 118-194 1.64e-03

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 37.33  E-value: 1.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485877211  118 FEPEVKRQAVMALSTRQVSASEIARRIGVSRAVLYKWKDEIIGNSAyqtmrkhnEPSLEAERDALREEVARLNQEIR 194
Cdd:pfam01527   7 FSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMG--------ASPARPRLTALEEENRRLKRELA 75
PRK14702 PRK14702
insertion element IS2 transposase InsD; Provisional
 284-506 1.93e-03

insertion element IS2 transposase InsD; Provisional


Pssm-ID: 237792 [Multi-domain]  Cd Length: 262  Bit Score: 40.10  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 284 YGYRRLHAMLRHEG-----VRLSEKVVRRLMVEEQLVVSRNRRrryssycgeIGPAPDNLIARdFKAEQPNQKWLTDITE 358
Cdd:PRK14702  27 YGYRRVWALLRRQAeldgmPAINAKRVYRLMRQNALLLERKPA---------VPPSKRAHTGR-VAVKESNQRWCSDGFE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 359 FQLPAG-KVWLSPVVDCFDGKVVSWSLSTRP-DAELVNTMLDSAVKTLNAGERPVIH----SDRGGHYRWPGWLERVNAA 432
Cdd:PRK14702  97 FCCDNGeRLRVTFALDCCDREALHWAVTTGGfNSETVQDVMLGAVERRFGNDLPSSPvewlTDNGSCYRANETRQFARML 176

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485877211 433 GLIRSMSRKGCSPDNAACEGFFGRLKTE-MYYGRKWSGITPEKFMQQVdayIRWYNERRIKLSLGAVSPKMYRQQ 506
Cdd:PRK14702 177 GLEPKNTAVRSPESNGIAESFVKTIKRDyISIMPKPDGLTAAKNLAEA---FEHYNEWHPHSALGYRSPREYLRQ 248
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
2-67 2.33e-03

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 37.21  E-value: 2.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485877211   2 FTEEEKIRAIELYFKYGKKLAPVVRELGYPSKRnLRRWIRSWEAGGGvkESIRHKHRYSDEQKQVA 67
Cdd:COG2963    8 YSPEFKAEAVRLVLEGGASVAEVARELGISPST-LYRWVRQYREGGL--GGFPGDGRTTPEQAEIR 70
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 6-58 8.80e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 34.49  E-value: 8.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 485877211    6 EKIRAIELYFKyGKKLAPVVRELGYpSKRNLRRWIRSWEAGGgvKESIRHKHR 58
Cdd:pfam13518   1 ERLKIVLLALE-GESIKEAARLFGI-SRSTVYRWIRRYREGG--LEGLLPRRR 49
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 284-506 9.50e-03

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 38.16  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 284 YGYRRLHAMLRHEG-----VRLSEKVVRRLMVEEQLVVSRNRRrryssycgeIGPAPDNLIARdFKAEQPNQKWLTDITE 358
Cdd:PRK09409  66 YGYRRVWALLRRQAeldgmPAINAKRVYRIMRQNALLLERKPA---------VPPSKRAHTGR-VAVKESNQRWCSDGFE 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485877211 359 FQLPAG-KVWLSPVVDCFDGKVVSWSLSTRP-DAELVNTMLDSAVKTLNAGERPVIH----SDRGGHYRWPGWLERVNAA 432
Cdd:PRK09409 136 FCCDNGeRLRVTFALDCCDREALHWAVTTGGfNSETVQDVMLGAVERRFGNDLPSSPvewlTDNGSCYRANETRQFARML 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485877211 433 GLIRSMSRKGCSPDNAACEGFFGRLKTE-MYYGRKWSGITPEKFMQQVdayIRWYNERRIKLSLGAVSPKMYRQQ 506
Cdd:PRK09409 216 GLEPKNTAVRSPESNGIAESFVKTIKRDyISIMPKPDGLTAAKNLAEA---FEHYNEWHPHSALGYRSPREYLRQ 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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