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Conserved domains on  [gi|486184177|ref|WP_001539605|]
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MULTISPECIES: (d)CMP kinase [Salmonella]

Protein Classification

(d)CMP kinase( domain architecture ID 10785233)

(d)CMP kinase catalyzes the phosphorylation of cytidine monophosphate (CMP) or dCMP to produce cytidine diphosphate (CDP) or dCDP, using ATP as the preferred phosphoryl donor

CATH:  3.40.50.300
Gene Ontology:  GO:0036431|GO:0006220|GO:0005524
PubMed:  10218107

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-225 4.80e-130

Cytidylate kinase [Nucleotide transport and metabolism];


:

Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 365.50  E-value: 4.80e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILEGE 85
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  86 DVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEN 165
Cdd:COG0283   81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177 166 GFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQKLA 225
Cdd:COG0283  161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-225 4.80e-130

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 365.50  E-value: 4.80e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILEGE 85
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  86 DVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEN 165
Cdd:COG0283   81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177 166 GFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQKLA 225
Cdd:COG0283  161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 4-220 1.68e-120

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 341.33  E-value: 1.68e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177    4 IAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILE 83
Cdd:TIGR00017   1 MAMIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNGEVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   84 GEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQ 163
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 486184177  164 ENGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYA 220
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKILEYA 217
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 8-222 3.27e-114

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 325.03  E-value: 3.27e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177    8 ITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTdgnlEVILEGEDV 87
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHT----EVFLNGEDV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   88 SGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQENGF 167
Cdd:pfam02224  77 SSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 486184177  168 SVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQ 222
Cdd:pfam02224 157 SVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIKQ 211
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
2-223 1.16e-89

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 277.31  E-value: 1.16e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   2 TAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDgnleVI 81
Cdd:PRK11860 439 ADRVPVICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRFEGDR----IW 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  82 LEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQ 161
Cdd:PRK11860 515 LGGEDVTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQ 594

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 486184177 162 LQENGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQK 223
Cdd:PRK11860 595 LISKGISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVLDWWQER 656
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 7-205 8.67e-70

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 210.04  E-value: 8.67e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGaiyrvlalaalhhhvdlasedalvplashldvrfvstdgnlevileged 86
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------- 31

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  87 vsgEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQENG 166
Cdd:cd02020   32 ---GIRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 486184177 167 FSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDST 205
Cdd:cd02020  109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-225 4.80e-130

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 365.50  E-value: 4.80e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILEGE 85
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  86 DVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEN 165
Cdd:COG0283   81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177 166 GFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQKLA 225
Cdd:COG0283  161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 4-220 1.68e-120

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 341.33  E-value: 1.68e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177    4 IAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILE 83
Cdd:TIGR00017   1 MAMIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNGEVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   84 GEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQ 163
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 486184177  164 ENGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYA 220
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKILEYA 217
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 8-222 3.27e-114

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 325.03  E-value: 3.27e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177    8 ITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTdgnlEVILEGEDV 87
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHT----EVFLNGEDV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   88 SGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQENGF 167
Cdd:pfam02224  77 SSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 486184177  168 SVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQ 222
Cdd:pfam02224 157 SVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIKQ 211
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
2-223 1.16e-89

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 277.31  E-value: 1.16e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   2 TAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDgnleVI 81
Cdd:PRK11860 439 ADRVPVICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRFEGDR----IW 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  82 LEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQ 161
Cdd:PRK11860 515 LGGEDVTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQ 594

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 486184177 162 LQENGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQK 223
Cdd:PRK11860 595 LISKGISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVLDWWQER 656
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
6-224 3.23e-71

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 225.53  E-value: 3.23e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   6 PVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRF-VSTDGNLEVILEG 84
Cdd:PRK13477 285 PIIAIDGPAGAGKSTVTRAVAKKLGLLYLDTGAMYRAVTWLVLQEGIDPQDEEALAELLSDLKIELkPSSGSPQRVWING 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  85 EDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQE 164
Cdd:PRK13477 365 EDVTEAIRSPEVTSSVSAIAAQPAVRQALVKQQQRIGEKGGLVAEGRDIGTHVFPDAELKIFLTASVEERARRRALDLQA 444

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 486184177 165 NGFSV-NFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQKL 224
Cdd:PRK13477 445 QGFPViDLEQLEAQIAERDRLDSTREIAPLRKADDAIELITDGLSIEEVVDKIIDLYRDRI 505
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 7-205 8.67e-70

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 210.04  E-value: 8.67e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGaiyrvlalaalhhhvdlasedalvplashldvrfvstdgnlevileged 86
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------- 31

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  87 vsgEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQENG 166
Cdd:cd02020   32 ---GIRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 486184177 167 FSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDST 205
Cdd:cd02020  109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 7-218 1.08e-47

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 166.89  E-value: 1.08e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASE--------DALVPLASHLDVRFVSTDGNL 78
Cdd:PRK09518   3 IVAIDGPAGVGKSSVSRALAQYLGYAYLDTGAMYRACAWWCLKQGIDLDAElvdeqvvtEAVGEFFTGLHFDISVDPDSP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  79 EVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRA----------FRKAPGLIADGRDMGTVVFPDAPVKIFLD 148
Cdd:PRK09518  83 GVFADGEDISEEIRSPEVSSHVSAVAAIPPVRNVLIAAQRAyiareasadsFSGGLGIVAEGRDITTVVAPDAEVRILLT 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177 149 ASSEERAHRRMLQLQEngfsVNFERLLAEIKERDDRDrNRAVAPLVPAADALVLDSTRLSIEQVIEKALQ 218
Cdd:PRK09518 163 AREEVRQARRSGQDRS----ETPGVVLEDVAARDEAD-SKVTSFLSAADGVTTLDNSDLDFDETLDLLIG 227
PRK12269 PRK12269
bifunctional cytidylate kinase/ribosomal protein S1; Provisional
 7-223 4.36e-29

bifunctional cytidylate kinase/ribosomal protein S1; Provisional


Pssm-ID: 105491 [Multi-domain]  Cd Length: 863  Bit Score: 114.42  E-value: 4.36e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASED-------------ALVPLASHLDVRFVS 73
Cdd:PRK12269  36 IIALDGPAGSGKSSVCRLLASRLGAQCLNTGSFYRAFTLAALRRVSELAVQAcspspdpdaavgcAAVPHATNLDTSYAP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  74 TDGNLEVIL------------------------EGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRKAPGLIAD 129
Cdd:PRK12269 116 LTAQKKVALfdeaywvsfartvalsyragvmyvGEENVESLLRSDEVESAVSYFAAMPAIRAIMTGKIRSAVCGARVVCE 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177 130 GRDMGTVVFPDAPVKIFLDASSEERAHRRMLQlqenGFS-VNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLS 208
Cdd:PRK12269 196 GRDLTTVVFVDADLKCYLDASIEARVARRWAQ----GTSrLSKQELEQRMRARDAHDRARTVGGLRCAPDALYVDTSCLT 271

                        250
                 ....*....|....*
gi 486184177 209 IEQVIEKALQYARQK 223
Cdd:PRK12269 272 IEEVCERIAREAHRR 286
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
7-225 1.28e-12

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 64.08  E-value: 1.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDsGAIyrvLALAALHHHVDLAsedalvpLASHLDVRFVStdgnlevILEGED 86
Cdd:COG1102    2 VITISREPGSGGTTIAKRLAEKLGLPLYD-GEI---LREAAKERGLSEE-------EFEKLDEKAPS-------LLYRDT 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  87 VSGEirtqevanaasqvaafpRVREALLRRQRAFRKAPGLIADGRdMGTVVFPDAP--VKIFLDASSEERAHRrmLQLQE 164
Cdd:COG1102   64 AEED-----------------EIDRALDKVIRELARKGNCVIVGR-LADWILRDRPnvLKVFLTAPLEVRVKR--IAERE 123

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177 165 NgfsVNFERLLAEIKERDDRDRNR-----AVAPlvpaADA----LVLDSTRLSIEQVIEKALQYARQKLA 225
Cdd:COG1102  124 G---ISEEEAEKEIKKRDKSRAKYykyyyGIDW----GDPsnydLVINTSRLGIEEAVDLILAAIEAREK 186
PRK04182 PRK04182
cytidylate kinase; Provisional
 7-224 1.41e-08

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 52.50  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLA------LAALHhhvDLASEDalvplashldvrfvstdgnlev 80
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAkergmsLEEFN---KYAEED---------------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  81 ilegedvsgeirtqevanaasqvaafPRVREALLRRQRAF-RKAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRrm 159
Cdd:PRK04182  57 --------------------------PEIDKEIDRRQLEIaEKEDNVVLEGRLAGWMAKDYADLKIWLKAPLEVRAER-- 108

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 486184177 160 LQLQENGfsvNFERLLAEIKERDDRDRNRA-------VAPLVPaADaLVLDSTRLSIEQVIEKALQYARQKL 224
Cdd:PRK04182 109 IAEREGI---SVEEALEETIEREESEAKRYkeyygidIDDLSI-YD-LVINTSRWDPEGVFDIILTAIDKLL 175
PRK06547 PRK06547
hypothetical protein; Provisional
 5-125 1.59e-04

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 40.88  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   5 APVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVL-ALAALHHHVdlaSEDALVPLAS-------HLDVR--FVST 74
Cdd:PRK06547  15 MITVLIDGRSGSGKTTLAGALAARTGFQLVHLDDLYPGWhGLAAASEHV---AEAVLDEGRPgrwrwdwANNRPgdWVSV 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 486184177  75 DGNLEVILEGedvSGEIrTQEVANAASQVAAFPRVR----EAlLRRQRAFRKAPG 125
Cdd:PRK06547  92 EPGRRLIIEG---VGSL-TAANVALASLLGEVLTVWldgpEA-LRKERALARDPD 141
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 7-40 6.70e-04

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 36.93  E-value: 6.70e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEAL---QWHLLDSGAIY 40
Cdd:cd02019    1 IIAITGGSGSGKSTVAKKLAEQLggrSVVVLDEIVIL 37
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 7-34 2.96e-03

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 37.59  E-value: 2.96e-03
                         10        20
                 ....*....|....*....|....*...
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALQWHLL 34
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVV 28
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 7-214 3.29e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 37.51  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177   7 VITIDGPSGAGKGTLCKAMAEALqwhlldsgaiyRVLALAALHH---HVDLA--------SEDALVPLASHLDVRfvstD 75
Cdd:COG0572    9 IIGIAGPSGSGKTTFARRLAEQL-----------GADKVVVISLddyYKDREhlpldergKPNFDHPEAFDLDLL----N 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486184177  76 GNLEVILEGEDVsgeirtqevanaasQVAAFPRVREALLRRQRAFRKAPGLIADG----RDmgTVVFPDAPVKIFLDASS 151
Cdd:COG0572   74 EHLEPLKAGESV--------------ELPVYDFATGTRSGETVKVEPADVIIVEGihalND--ELLRDLLDLKIYVDADT 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 486184177 152 EERAHRRMLQ-LQENGFSVnfERLLAEIKERDDRDRNRAVAPLVPAADaLVLDSTRLSIEQVIE 214
Cdd:COG0572  138 DVRLIRRIVRdGEERGRTA--ESVIEQYWATVRPGHEQYIEPTKEYAD-IVIPNGGPLNPVALD 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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