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Conserved domains on  [gi|486285266|ref|WP_001571843|]
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MULTISPECIES: tetratricopeptide repeat protein [Bacteria]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15331 super family cl30292
type III secretion system translocator chaperone SicA;
11-155 1.17e-34

type III secretion system translocator chaperone SicA;


The actual alignment was detected with superfamily member PRK15331:

Pssm-ID: 357168  Cd Length: 165  Bit Score: 119.01  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486285266  11 NSDEWASQLKHALSQGENLALLHGLTPDILDRIYAYAFDYHEKGNITDAEIYYKFLCIYAFENHEYLKGFASVCQSKKKY 90
Cdd:PRK15331   8 SEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAVCQLKKQF 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 486285266  91 QQAYGLYKLSYNYSPyDDYSVIYRMGQCQIGAKNIDNAMQCFYHIINNCEDESVKSKAQAYIELL 155
Cdd:PRK15331  88 QKACDLYAVAFTLLK-NDYRPVFFTGQCQLLMRKAAKARQCFELVNERTEDESLRAKALVYLEAL 151
 
Name Accession Description Interval E-value
PRK15331 PRK15331
type III secretion system translocator chaperone SicA;
11-155 1.17e-34

type III secretion system translocator chaperone SicA;


Pssm-ID: 185231  Cd Length: 165  Bit Score: 119.01  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486285266  11 NSDEWASQLKHALSQGENLALLHGLTPDILDRIYAYAFDYHEKGNITDAEIYYKFLCIYAFENHEYLKGFASVCQSKKKY 90
Cdd:PRK15331   8 SEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAVCQLKKQF 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 486285266  91 QQAYGLYKLSYNYSPyDDYSVIYRMGQCQIGAKNIDNAMQCFYHIINNCEDESVKSKAQAYIELL 155
Cdd:PRK15331  88 QKACDLYAVAFTLLK-NDYRPVFFTGQCQLLMRKAAKARQCFELVNERTEDESLRAKALVYLEAL 151
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 24-155 8.54e-16

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 69.63  E-value: 8.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486285266   24 SQGENLALLHGLTPDILDRIYAYAFDYHEKGNITDAEIYYKFLCIYAFENHEYLKGFASVCQSKKKYQQAYGLYKLSYNY 103
Cdd:TIGR02552   1 SGGATLKDLLGLDSEQLEQIYALAYNLYQQGRYDEALKLFQLLAAYDPYNSRYWLGLAACCQMLKEYEEAIDAYALAAAL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 486285266  104 SPyDDYSVIYRMGQCQIGAKNIDNAMQCFYHIINNCEDES----VKSKAQAYIELL 155
Cdd:TIGR02552  81 DP-DDPRPYFHAAECLLALGEPESALKALDLAIEICGENPeyseLKERAEAMLESL 135
TPR_3 pfam07720
Tetratricopeptide repeat; This Pfam entry includes tetratricopeptide-like repeats found in the ...
 40-73 5.16e-06

Tetratricopeptide repeat; This Pfam entry includes tetratricopeptide-like repeats found in the LcrH/SycD-like chaperones.


Pssm-ID: 400185  Cd Length: 34  Bit Score: 41.33  E-value: 5.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 486285266   40 LDRIYAYAFDYHEKGNITDAEIYYKFLCIYAFEN 73
Cdd:pfam07720   1 LDYLYSLAAVFYLKGKYQEARHLYSLLAILDKEN 34
 
Name Accession Description Interval E-value
PRK15331 PRK15331
type III secretion system translocator chaperone SicA;
11-155 1.17e-34

type III secretion system translocator chaperone SicA;


Pssm-ID: 185231  Cd Length: 165  Bit Score: 119.01  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486285266  11 NSDEWASQLKHALSQGENLALLHGLTPDILDRIYAYAFDYHEKGNITDAEIYYKFLCIYAFENHEYLKGFASVCQSKKKY 90
Cdd:PRK15331   8 SEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAVCQLKKQF 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 486285266  91 QQAYGLYKLSYNYSPyDDYSVIYRMGQCQIGAKNIDNAMQCFYHIINNCEDESVKSKAQAYIELL 155
Cdd:PRK15331  88 QKACDLYAVAFTLLK-NDYRPVFFTGQCQLLMRKAAKARQCFELVNERTEDESLRAKALVYLEAL 151
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 24-155 8.54e-16

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 69.63  E-value: 8.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486285266   24 SQGENLALLHGLTPDILDRIYAYAFDYHEKGNITDAEIYYKFLCIYAFENHEYLKGFASVCQSKKKYQQAYGLYKLSYNY 103
Cdd:TIGR02552   1 SGGATLKDLLGLDSEQLEQIYALAYNLYQQGRYDEALKLFQLLAAYDPYNSRYWLGLAACCQMLKEYEEAIDAYALAAAL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 486285266  104 SPyDDYSVIYRMGQCQIGAKNIDNAMQCFYHIINNCEDES----VKSKAQAYIELL 155
Cdd:TIGR02552  81 DP-DDPRPYFHAAECLLALGEPESALKALDLAIEICGENPeyseLKERAEAMLESL 135
TPR_3 pfam07720
Tetratricopeptide repeat; This Pfam entry includes tetratricopeptide-like repeats found in the ...
 40-73 5.16e-06

Tetratricopeptide repeat; This Pfam entry includes tetratricopeptide-like repeats found in the LcrH/SycD-like chaperones.


Pssm-ID: 400185  Cd Length: 34  Bit Score: 41.33  E-value: 5.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 486285266   40 LDRIYAYAFDYHEKGNITDAEIYYKFLCIYAFEN 73
Cdd:pfam07720   1 LDYLYSLAAVFYLKGKYQEARHLYSLLAILDKEN 34
TPR_3 pfam07720
Tetratricopeptide repeat; This Pfam entry includes tetratricopeptide-like repeats found in the ...
 74-107 1.21e-05

Tetratricopeptide repeat; This Pfam entry includes tetratricopeptide-like repeats found in the LcrH/SycD-like chaperones.


Pssm-ID: 400185  Cd Length: 34  Bit Score: 40.17  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 486285266   74 HEYLKGFASVCQSKKKYQQAYGLYKLSYNYSPYD 107
Cdd:pfam07720   1 LDYLYSLAAVFYLKGKYQEARHLYSLLAILDKEN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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