NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|487377240|ref|WP_001650203|]
View 

MULTISPECIES: 50S ribosomal protein L3 N(5)-glutamine methyltransferase [Salmonella]

Protein Classification

ribosomal protein L3 N(5)-glutamine methyltransferase( domain architecture ID 11497021)

ribosomal protein L3 N(5)-glutamine methyltransferase specifically methylates the 50S ribosomal protein L3 on Gln-150 using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; does not methylate the translation termination release factors RF1 and RF2; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
EC:  2.1.1.298
Gene Ontology:  GO:0008757|GO:0006479|GO:1904047|GO:0018364
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


:

Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 577.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   13 LHTIQDMLRWAVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRINERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLIS-QQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEpEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  172 AEHNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAPDY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 487377240  252 LSDDGVLICEVGNSMVHLMEQYPNVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 577.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   13 LHTIQDMLRWAVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRINERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLIS-QQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEpEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  172 AEHNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAPDY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 487377240  252 LSDDGVLICEVGNSMVHLMEQYPNVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 14-266 1.08e-106

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 312.08  E-value: 1.08e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  14 HTIQDMLRWAVSRFSAAniwyghGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRiNERIPVAYL 93
Cdd:COG2890    1 MTIRELLRWAAARLAAA------GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARR-AAGEPLAYI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  94 TNKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLISQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAE 173
Cdd:COG2890   74 LGEAEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVAR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 174 HNIEEHGLIHHVTPIRSDLFRDLPKV-QYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTRRILGNAPDY 251
Cdd:COG2890  154 RNAERLGLEDRVRFLQGDLFEPLPGDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                        250
                 ....*....|....*
gi 487377240 252 LSDDGVLICEVGNSM 266
Cdd:COG2890  234 LKPGGWLLLEIGEDQ 248
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 15-263 4.83e-70

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 218.49  E-value: 4.83e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  15 TIQDMLRWAVSRFSAaniwyghgtdnPWDEAVQLV-----LPSLYLPLDIPEDmrtarLTSSEKHRIVERVIRRINeRIP 89
Cdd:PRK09328   3 TIAEALREATARLAS-----------PRLDAELLLahvlgLSRTDLLLNPEEE-----LTPEELERFRALVARRAA-GEP 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  90 VAYLTNKAWFCGHEFYVDERVLVPRsP----IGELINNHFAGlisQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDIS 165
Cdd:PRK09328  66 LQYILGEAEFWGLDFKVSPGVLIPR-PeteeLVEWALEALLL---KEPLRVLDLGTGSGAIALALAKERPDAEVTAVDIS 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 166 PDALAVAEHNIeEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTRRI 244
Cdd:PRK09328 142 PEALAVARRNA-KHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRI 220

                        250
                 ....*....|....*....
gi 487377240 245 LGNAPDYLSDDGVLICEVG 263
Cdd:PRK09328 221 IEQAPRYLKPGGWLLLEIG 239
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 136-265 2.75e-17

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 77.63  E-value: 2.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  136 ILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLiHHVTPIRSDLFRDLPKVQYDLIVTNPPYvdaed 215
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDLIISNPPF----- 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 487377240  216 msdlpneyrHEpelGLASGTDglkLTRRILGNAPDYLSDDGVLICeVGNS 265
Cdd:pfam05175 109 ---------HA---GLATTYN---VAQRFIADAKRHLRPGGELWI-VANR 142
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 136-210 3.43e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.89  E-value: 3.43e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487377240 136 ILDMCTGSGCIAIAcAYAFPDAEVDAVDISPDALAVAEHNiEEHGLIHHVTPIRSDLFRDLPKV--QYDLIVTNPPY 210
Cdd:cd02440    2 VLDLGCGTGALALA-LASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPL 76
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 577.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   13 LHTIQDMLRWAVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRINERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLIS-QQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEpEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  172 AEHNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAPDY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 487377240  252 LSDDGVLICEVGNSMVHLMEQYPNVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 15-303 2.68e-139

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 394.80  E-value: 2.68e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   15 TIQDMLRWAVSRFSAANIWyghgtDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRINErIPVAYLT 94
Cdd:TIGR00536   2 TIQEFLRWASSALSRAIAR-----ENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKG-VPVAYLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   95 NKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLISQQP-KYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAE 173
Cdd:TIGR00536  76 GSKEFYGLEFFVNEHVLIPRPETEELVEKALASLISQPPiLHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  174 HNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAPDYLS 253
Cdd:TIGR00536 156 ENAEKNQLEHRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLK 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 487377240  254 DDGVLICEVGNSMVHLMEQYPNVPFTWLEFDNGGDgVFMLTKAQLLAARE 303
Cdd:TIGR00536 236 PNGFLVCEIGNWQQKSLKELLRIKFTWYDVENGRD-LNGKERVVLGFYHS 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 14-266 1.08e-106

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 312.08  E-value: 1.08e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  14 HTIQDMLRWAVSRFSAAniwyghGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRiNERIPVAYL 93
Cdd:COG2890    1 MTIRELLRWAAARLAAA------GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARR-AAGEPLAYI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  94 TNKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLISQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAE 173
Cdd:COG2890   74 LGEAEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVAR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 174 HNIEEHGLIHHVTPIRSDLFRDLPKV-QYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTRRILGNAPDY 251
Cdd:COG2890  154 RNAERLGLEDRVRFLQGDLFEPLPGDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                        250
                 ....*....|....*
gi 487377240 252 LSDDGVLICEVGNSM 266
Cdd:COG2890  234 LKPGGWLLLEIGEDQ 248
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 15-263 4.83e-70

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 218.49  E-value: 4.83e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  15 TIQDMLRWAVSRFSAaniwyghgtdnPWDEAVQLV-----LPSLYLPLDIPEDmrtarLTSSEKHRIVERVIRRINeRIP 89
Cdd:PRK09328   3 TIAEALREATARLAS-----------PRLDAELLLahvlgLSRTDLLLNPEEE-----LTPEELERFRALVARRAA-GEP 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  90 VAYLTNKAWFCGHEFYVDERVLVPRsP----IGELINNHFAGlisQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDIS 165
Cdd:PRK09328  66 LQYILGEAEFWGLDFKVSPGVLIPR-PeteeLVEWALEALLL---KEPLRVLDLGTGSGAIALALAKERPDAEVTAVDIS 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 166 PDALAVAEHNIeEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTRRI 244
Cdd:PRK09328 142 PEALAVARRNA-KHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRI 220

                        250
                 ....*....|....*....
gi 487377240 245 LGNAPDYLSDDGVLICEVG 263
Cdd:PRK09328 221 IEQAPRYLKPGGWLLLEIG 239
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 68-274 9.14e-67

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 209.25  E-value: 9.14e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   68 LTSSEKHRIVERVIRRInERIPVAYLTNKAWFCGHEFYVDERVLVPRsPIGELINNHFAGLISQQPKyILDMCTGSGCIA 147
Cdd:TIGR03534  25 LTPEELAAFDALLARRA-AGEPVAYILGEREFYGLDFKVSPGVLIPR-PETEELVEAALERLKKGPR-VLDLGTGSGAIA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  148 IACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLiHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYR-HE 226
Cdd:TIGR03534 102 LALAKERPDARVTAVDISPEALAVARKNARRLGL-ENVEFLQGDWFEPLPSGKFDLIVSNPPYIPEADIHLLDPEVRdFE 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 487377240  227 PELGLASGTDGLKLTRRILGNAPDYLSDDGVLICEVG----NSMVHLMEQYP 274
Cdd:TIGR03534 181 PRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGydqgEAVRALFEAAG 232
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 37-263 2.56e-28

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 113.81  E-value: 2.56e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  37 GTDNPWDEA---VQLVL--PSLYLPLDIPEDMRTARLTSsekhriVERVIRRINERIPVAYLTNKAWFCGHEFYVDERVL 111
Cdd:PRK01544  20 GISSPQLEArilLQHVInkPIEYLLINLDEQLNEAEIEA------FEKLLERRLKHEPIAYITGVKEFYSREFIVNKHVL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 112 VPRSPIGELIN------------------------NHFAGLISQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPD 167
Cdd:PRK01544  94 IPRSDTEVLVDvvfqchsresgnpekkqlnpcfrgNDISSNCNDKFLNILELGTGSGCIAISLLCELPNANVIATDISLD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 168 ALAVAEHNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNE-YRHEPELGLASGTDGLKLTRRILG 246
Cdd:PRK01544 174 AIEVAKSNAIKYEVTDRIQIIHSNWFENIEKQKFDFIVSNPPYISHSEKSEMAIEtINYEPSIALFAEEDGLQAYFIIAE 253

                        250
                 ....*....|....*..
gi 487377240 247 NAPDYLSDDGVLICEVG 263
Cdd:PRK01544 254 NAKQFLKPNGKIILEIG 270
PrmC_rel_meth TIGR03704
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ...
 65-263 9.51e-25

putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274733 [Multi-domain]  Cd Length: 251  Bit Score: 99.86  E-value: 9.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240   65 TARlTSSEKHRIVERVIrrinERIPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELINNHFA-GLISQQPKYILDMCTGS 143
Cdd:TIGR03704  23 AAR-TPGELAAMVDRRV----AGLPLEHVLGWAEFCGLRIAVDPGVFVPRRRTEFLVDEAAAlARPRSGTLVVVDLCCGS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  144 GCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGL-IHHvtpirSDLFRDLPKV---QYDLIVTNPPYVDAEDMSDL 219
Cdd:TIGR03704  98 GAVGAALAAALDGIELHAADIDPAAVRCARRNLADAGGtVHE-----GDLYDALPTAlrgRVDILAANAPYVPTDAIALM 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 487377240  220 PNEYR-HEPELGLASGTDGLKLTRRILGNAPDYLSDDGVLICEVG 263
Cdd:TIGR03704 173 PPEARdHEPRVALDGGADGLDVLRRVAAGAPDWLAPGGHLLVETS 217
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 82-263 4.66e-23

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 98.23  E-value: 4.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  82 RRINERiPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLisQQPKYILDMCTGSGCIAIACAYAFPDAEVDA 161
Cdd:PRK14966 204 RRLNGE-PVAYILGVREFYGRRFAVNPNVLIPRPETEHLVEAVLARL--PENGRVWDLGTGSGAVAVTVALERPDAFVRA 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 162 VDISPDALAVAEHNIEEHGLihHVTPIRSDLF-RDLP-KVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLK 239
Cdd:PRK14966 281 SDISPPALETARKNAADLGA--RVEFAHGSWFdTDMPsEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLS 358

                        170       180
                 ....*....|....*....|....
gi 487377240 240 LTRRILGNAPDYLSDDGVLICEVG 263
Cdd:PRK14966 359 CIRTLAQGAPDRLAEGGFLLLEHG 382
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 136-269 2.84e-22

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 91.79  E-value: 2.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 136 ILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLiHHVTPIRSDLFRDLPKVQYDLIVTNPPYvdaed 215
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGL-ENVEVLWSDGLSGVPDGSFDLILSNPPF----- 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 487377240 216 msdlpneyrHepelglASGTDGLKLTRRILGNAPDYLSDDGVLICeVGNSmvHL 269
Cdd:COG2813  127 ---------H------AGRAVDKEVAHALIADAARHLRPGGELWL-VANR--HL 162
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 124-232 9.53e-21

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 88.66  E-value: 9.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 124 HFAGLisQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDL---FRDLPKVQ 200
Cdd:COG4123   31 AFAPV--KKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLkefAAELPPGS 108

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 487377240 201 YDLIVTNPPYVDAEDMSDLPNEY----RHEPELGLA 232
Cdd:COG4123  109 FDLVVSNPPYFKAGSGRKSPDEAraiaRHEDALTLE 144
PRK14968 PRK14968
putative methyltransferase; Provisional
 136-257 2.72e-18

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 81.10  E-value: 2.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 136 ILDMCTGSGCIAIACAYAfpDAEVDAVDISPDALAVAEHNIEEHGLIHH-VTPIRSDLFRDLPKVQYDLIVTNPPYvdae 214
Cdd:PRK14968  27 VLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFEPFRGDKFDVILFNPPY---- 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 487377240 215 dmsdLPNEYRHEP----ELGLASGTDGLKLTRRILGNAPDYLSDDGV 257
Cdd:PRK14968 101 ----LPTEEEEEWddwlNYALSGGKDGREVIDRFLDEVGRYLKPGGR 143
PRK14967 PRK14967
putative methyltransferase; Provisional
 136-259 1.28e-17

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 80.10  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 136 ILDMCTGSGCIAIACAYAfPDAEVDAVDISPDALAVAEHNIEEHGliHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAED 215
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAA-GAGSVTAVDISRRAVRSARLNALLAG--VDVDVRRGDWARAVEFRPFDVVVSNPPYVPAPP 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 487377240 216 MSdlpneyrhEPELGLA----SGTDGLKLTRRILGNAPDYLSDDGVLI 259
Cdd:PRK14967 117 DA--------PPSRGPArawdAGPDGRAVLDRLCDAAPALLAPGGSLL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 136-265 2.75e-17

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 77.63  E-value: 2.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  136 ILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLiHHVTPIRSDLFRDLPKVQYDLIVTNPPYvdaed 215
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDLIISNPPF----- 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 487377240  216 msdlpneyrHEpelGLASGTDglkLTRRILGNAPDYLSDDGVLICeVGNS 265
Cdd:pfam05175 109 ---------HA---GLATTYN---VAQRFIADAKRHLRPGGELWI-VANR 142
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
136-209 5.42e-11

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 60.69  E-value: 5.42e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487377240 136 ILDMCTGSGCIAIACAYAFPdAEVDAVDISPDALAVAEHNIEEHGLIHHVtpIRSDLFRDLPKVQYDLIVTNPP 209
Cdd:COG2263   49 VLDLGCGTGMLAIGAALLGA-KKVVGVDIDPEALEIARENAERLGVRVDF--IRADVTRIPLGGSVDTVVMNPP 119
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 136-207 1.61e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.11  E-value: 1.61e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487377240  136 ILDMCTGSGCIAIACAYAFpDAEVDAVDISPDALAVAEHNIEEHGLihHVTPIRSDlFRDLPKV--QYDLIVTN 207
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGD-AEDLPFPdgSFDLVVSS 70
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
131-207 7.46e-09

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 55.56  E-value: 7.46e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487377240 131 QQPKYILDMCTGSGCIAIACAYAFPdAEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDLFRDLPkvqYDLIVTN 207
Cdd:COG2264  147 KPGKTVLDVGCGSGILAIAAAKLGA-KRVLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLLEDGP---YDLVVAN 219
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 134-210 1.42e-08

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 53.11  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  134 KYILDMCTGSGCIAIACAYAFPdaEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDLFRDL-----PKVQYDLIVTNP 208
Cdd:pfam09445   2 TRILDVFCGGGGNTIQFANVFD--SVISIDINLEHLACAQHNAEVYGVSDRIWLIHGDWFELLaklkfEKIKYDCVFASP 79


                  ..
gi 487377240  209 PY 210
Cdd:pfam09445  80 PW 81
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
132-207 3.39e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.59  E-value: 3.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487377240 132 QPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEehglihHVTPIRSDLFRDLPKVQYDLIVTN 207
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLP------NVRFVVADLRDLDPPEPFDLVVSN 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 136-210 3.43e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.89  E-value: 3.43e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487377240 136 ILDMCTGSGCIAIAcAYAFPDAEVDAVDISPDALAVAEHNiEEHGLIHHVTPIRSDLFRDLPKV--QYDLIVTNPPY 210
Cdd:cd02440    2 VLDLGCGTGALALA-LASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPL 76
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 136-205 5.91e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 51.47  E-value: 5.91e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487377240 136 ILDMCTGSGCIAIACAYAFpDAEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDlFRDLPKV-QYDLIV 205
Cdd:COG2230   55 VLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLAD-YRDLPADgQFDAIV 123
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 134-219 5.97e-08

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 51.49  E-value: 5.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 134 KYILDMCTGSGCIAIACAYAfpDAEVDAVDISPDALAVAEHNIEeHGLIHHVTPIRSDlFRDLP--KVQYDLIVTNPPY- 210
Cdd:COG1041   28 DTVLDPFCGTGTILIEAGLL--GRRVIGSDIDPKMVEGARENLE-HYGYEDADVIRGD-ARDLPlaDESVDAIVTDPPYg 103

                         90
                 ....*....|...
gi 487377240 211 ----VDAEDMSDL 219
Cdd:COG1041  104 rsskISGEELLEL 116
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
131-207 3.67e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 50.15  E-value: 3.67e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487377240 131 QQPKYILDMCTGSGCIAIACAY--AfpdAEVDAVDISPDALAVAEHNIEEHGLIHHVTpirsdLFRDLPKvqYDLIVTN 207
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKlgA---KKVLAVDIDPQAVEAARENAELNGVELNVY-----LPQGDLK--ADVIVAN 186
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 163-210 4.06e-07

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 50.87  E-value: 4.06e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 487377240 163 DISPDALAVAEHNIEEHGLIHHVTPIRSDlFRDL-PKVQYDLIVTNPPY 210
Cdd:COG0116  257 DIDPRAIEAARENAERAGVADLIEFEQAD-FRDLePPAEPGLIITNPPY 304
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 136-210 7.47e-07

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 49.86  E-value: 7.47e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487377240 136 ILDMCTGSGCIAIACAyAFPDAEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDlFRDLP---KVQYDLIVTNPPY 210
Cdd:COG2520  184 VLDMFAGVGPFSIPIA-KRSGAKVVAIDINPDAVEYLKENIRLNKVEDRVTPILGD-AREVApelEGKADRIIMNLPH 259
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 157-209 1.41e-06

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 49.41  E-value: 1.41e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 487377240 157 AEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDLF---RDLPKV--QYDLIVTNPP 209
Cdd:COG1092  240 KSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFdwlRELAREgeRFDLIILDPP 297
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 136-198 1.75e-06

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 49.01  E-value: 1.75e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487377240 136 ILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLiHHVTPIR---SDLFRDLPK 198
Cdd:COG2242  251 LWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGV-PNVEVVEgeaPEALADLPD 315
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 131-207 3.04e-06

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 48.03  E-value: 3.04e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487377240  131 QQPKYILDMCTGSGCIAIACAYaFPDAEVDAVDISPDALAVAEHNIEEHGLIHHvtpIRSDLFRDLPKVQYDLIVTN 207
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALK-LGAKKVVGVDIDPVAVRAAKENAELNGVEAR---LEVYLPGDLPKEKADVVVAN 232
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 137-207 3.71e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.67  E-value: 3.71e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487377240  137 LDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGL--IHHVTPIRSDLFrDLPKVQYDLIVTN 207
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLlnAVRVELFQLDLG-ELDPGSFDVVVAS 72
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 122-207 1.36e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.85  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 122 NNHFAGLISQ---QPKYILDMCTGSGCIAIACAYAFpdAEVDAVDISPDALAVAEHNIEEHGlihhVTPIRSDLFR-DLP 197
Cdd:COG2227   11 DRRLAALLARllpAGGRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIARERAAELN----VDFVQGDLEDlPLE 84

                         90
                 ....*....|
gi 487377240 198 KVQYDLIVTN 207
Cdd:COG2227   85 DGSFDLVICS 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 136-207 1.73e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 43.83  E-value: 1.73e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487377240 136 ILDMCTGSGciAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLihHVTPIRSDLFR-DLPKVQYDLIVTN 207
Cdd:COG2226   26 VLDLGCGTG--RLALALAERGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDlPFPDGSFDLVISS 94
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
136-217 2.06e-05

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 45.70  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 136 ILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLIHHVtpIRSDLFRDLPKvQYDLIVTNPPYVDAED 215
Cdd:PRK09489 200 VLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEV--FASNVFSDIKG-RFDMIISNPPFHDGIQ 276


                 ..
gi 487377240 216 MS 217
Cdd:PRK09489 277 TS 278
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 134-272 3.19e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 43.17  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  134 KYILDMCTGSGCIAIACAY-AFPDAEVDAVDISPDALAVAEHNIEEHGLIhHVTPIRSDLFrDLPKV----QYDLIVTNP 208
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGDIE-ELPELleddKFDVVISNC 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487377240  209 PYVDAEDMSDlpneyrhepelglasgtdglkltrrILGNAPDYLSDDGVLICEVGNSMVHLMEQ 272
Cdd:pfam13847  83 VLNHIPDPDK-------------------------VLQEILRVLKPGGRLIISDPDSLAELPAH 121
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 130-232 4.55e-05

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 44.23  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  130 SQQPKYILDMCTGSGCIAIaCAYAFPDAEVDA----------VDISPDALA---VAEHNIEEHGL-IHHVTPIRSDLFRD 195
Cdd:pfam02384  43 PKPGESIYDPACGSGGFLI-QAEKFVKEHDGDtndlsiygqeKNPTTYRLArmnMILHGIEYDDFhIRHGDTLTSPKFED 121

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 487377240  196 LPKVqyDLIVTNPPYVDAEDMSD-LPNEYRHEPELGLA 232
Cdd:pfam02384 122 DKKF--DVVVANPPFSDKWDANDtLENDPRFRPAYGVA 157
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 136-205 6.16e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 43.37  E-value: 6.16e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487377240 136 ILDMCTGSGCIAIACAYAFpDAEVDAVDISPDALAVAEHNIEEHGLiHHVTPIRSDL--FRDLPKVQYDLIV 205
Cdd:COG0500   30 VLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLaeLDPLPAESFDLVV 99
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 163-210 8.13e-05

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 44.02  E-value: 8.13e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 487377240 163 DISPDALAVAEHNIEEHGLIHHVTPIRSD---LFRDLPKVQYDLIVTNPPY 210
Cdd:PRK11783 263 DIDPRVIQAARKNARRAGVAELITFEVKDvadLKNPLPKGPTGLVISNPPY 313
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 136-210 3.18e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 40.80  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  136 ILD-MCtGSGCIAIA-------CAYAFPDAEVDA----VDISPDALAVAEHNIEEHGLIHHVTpIRSDLFRDLP--KVQY 201
Cdd:pfam01170  32 LLDpMC-GSGTILIEaalmganIAPGKFDARVRAplygSDIDRRMVQGARLNAENAGVGDLIE-FVQADAADLPllEGSV 109


                  ....*....
gi 487377240  202 DLIVTNPPY 210
Cdd:pfam01170 110 DVIVTNPPY 118
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
134-181 3.41e-04

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 40.76  E-value: 3.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 487377240 134 KYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGL 181
Cdd:PRK08287  33 KHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGC 80
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 136-191 8.30e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 40.14  E-value: 8.30e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 487377240 136 ILDMCTGSGCIAIA-CAYAFPDAEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSD 191
Cdd:PRK00216  55 VLDLACGTGDLAIAlAKAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGD 111
PHA03411 PHA03411
putative methyltransferase; Provisional
 66-219 8.53e-04

putative methyltransferase; Provisional


Pssm-ID: 177639 [Multi-domain]  Cd Length: 279  Bit Score: 40.47  E-value: 8.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  66 ARLTSSEKhRIVERVIRRINERIPVAYltNKAWFCGHEFYVDE-----RVLVPRSPIGEL-INNHFAGlisqqpkYILDM 139
Cdd:PHA03411   2 ARLSKQEQ-KLHDRVMELINSDRPLTY--EEKEFCYNNYHGDGlggsgAFFTPEGLAWDFtIDAHCTG-------KVLDL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 140 CTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHnieehgLIHHVTPIRSDLFRDLPKVQYDLIVTNPPY--VDAEDMS 217
Cdd:PHA03411  72 CAGIGRLSFCMLHRCKPEKIVCVELNPEFARIGKR------LLPEAEWITSDVFEFESNEKFDVVISNPPFgkINTTDTK 145


                 ..
gi 487377240 218 DL 219
Cdd:PHA03411 146 DV 147
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
136-206 8.88e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 40.02  E-value: 8.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487377240 136 ILDMCTGSGCIAIACAYAFPDaEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVT 206
Cdd:COG4076   39 VLDIGTGSGLLSMLAARAGAK-KVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKADVIIS 108
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 136-210 1.92e-03

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 38.87  E-value: 1.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487377240  136 ILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPY 210
Cdd:pfam02475 103 VVDMFAGIGPFSIPIAKHSKARRVYAIELNPESYKYLKENIKLNKVEDVVKPILGDVREVILEDVADRVVMNLPG 177
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 128-207 2.42e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 38.81  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240  128 LISQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEhglihHVTPIRSDLFR-DLPKVQYDLIVT 206
Cdd:TIGR02072  30 KGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSE-----NVQFICGDAEKlPLEDSSFDLIVS 104


                  .
gi 487377240  207 N 207
Cdd:TIGR02072 105 N 105
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
136-209 3.92e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 38.35  E-value: 3.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487377240 136 ILDMCTGSGCIAIACAyAFPDAEVDAVDISPDALAVAEHNIEEHGLIH-HVTPIRSDLF---RDLPKVQYDLIVTNPP 209
Cdd:COG2521  136 VLDTCTGLGYTAIEAL-KRGAREVITVEKDPNVLELAELNPWSRELANeRIKIILGDASeviKTFPDESFDAIIHDPP 212
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
113-237 5.73e-03

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 37.47  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 113 PRsPIGELInnhfAGLISQQP-KYILDMCTGSGCIAIACA-YAFPDAEVDA-------VDISPDALAVAE-----HNIEE 178
Cdd:COG0286   28 PR-EVVRLM----VELLDPKPgETVYDPACGSGGFLVEAAeYLKEHGGDERkklslygQEINPTTYRLAKmnlllHGIGD 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 487377240 179 HGlIHHVTPIRSDLFRDLpkvQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDG 237
Cdd:COG0286  103 PN-IELGDTLSNDGDELE---KFDVVLANPPFGGKWKKEELKDDLLGRFGYGLPPKSNA 157
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
119-205 7.71e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 36.90  E-value: 7.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487377240 119 ELINNHFAGLISQQPKYILDMCTGSGciaiACAYAFPDA--EVDAVDISPDALAVAehniEEHGLIHHVtpIRSDlFRDL 196
Cdd:COG4976   33 LLAEELLARLPPGPFGRVLDLGCGTG----LLGEALRPRgyRLTGVDLSEEMLAKA----REKGVYDRL--LVAD-LADL 101

                         90
                 ....*....|.
gi 487377240 197 PKV--QYDLIV 205
Cdd:COG4976  102 AEPdgRFDLIV 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH