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Conserved domains on  [gi|487727424|ref|WP_001811656|]
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glycosyltransferase family 4 protein [Streptococcus pneumoniae]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10601751)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
38-180 2.56e-10

Glycosyltransferase Family 4;


:

Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 56.39  E-value: 2.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424   38 GGIDPHIIGLCKKQIRRmsLYPILIIVSRDSKVIDDYKNLDIAYVDCT-----QCSNNFETALHVKNILKLLKIRLIHCH 112
Cdd:pfam13439   1 GGVERYVLELARALARR--GHEVTVVTPGGPGPLAEEVVRVVRVPRVPlplppRLLRSLAFLRRLRRLLRRERPDVVHAH 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487727424  113 GYSTNYFLYMLKKLdkngFGKVKTVITCHGWVEY--------NLKKKFLTYFDFWTYSMGDAFICVSETMKKRLES 180
Cdd:pfam13439  79 SPFPLGLAALAARL----RLGIPLVVTYHGLFPDykrlgarlSPLRRLLRRLERRLLRRADRVIAVSEAVADELRR 150
 
Name Accession Description Interval E-value
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
38-180 2.56e-10

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 56.39  E-value: 2.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424   38 GGIDPHIIGLCKKQIRRmsLYPILIIVSRDSKVIDDYKNLDIAYVDCT-----QCSNNFETALHVKNILKLLKIRLIHCH 112
Cdd:pfam13439   1 GGVERYVLELARALARR--GHEVTVVTPGGPGPLAEEVVRVVRVPRVPlplppRLLRSLAFLRRLRRLLRRERPDVVHAH 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487727424  113 GYSTNYFLYMLKKLdkngFGKVKTVITCHGWVEY--------NLKKKFLTYFDFWTYSMGDAFICVSETMKKRLES 180
Cdd:pfam13439  79 SPFPLGLAALAARL----RLGIPLVVTYHGLFPDykrlgarlSPLRRLLRRLERRLLRRADRVIAVSEAVADELRR 150
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 28-181 8.08e-10

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 56.78  E-value: 8.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424  28 IIVRYNNGHCGGIDPHIIGLCKKQIRRMslYPILIIVSRDSKVIDDYKNLDIAYVDCTQCSNNFETALHVKNI---LKLL 104
Cdd:cd03801    4 LLSPELPPPVGGAERHVRELARALAARG--HDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELrplLRLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424 105 KIRLIHCHGYSTNYFLYMLKKLDKngfgkVKTVITCHG------WVEYNLKKKFLTYFDFWtYSMGDAFICVSETMKKRL 178
Cdd:cd03801   82 KFDVVHAHGLLAALLAALLALLLG-----APLVVTLHGaepgrlLLLLAAERRLLARAEAL-LRRADAVIAVSEALRDEL 155


                 ...
gi 487727424 179 ESI 181
Cdd:cd03801  156 RAL 158
 
Name Accession Description Interval E-value
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
38-180 2.56e-10

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 56.39  E-value: 2.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424   38 GGIDPHIIGLCKKQIRRmsLYPILIIVSRDSKVIDDYKNLDIAYVDCT-----QCSNNFETALHVKNILKLLKIRLIHCH 112
Cdd:pfam13439   1 GGVERYVLELARALARR--GHEVTVVTPGGPGPLAEEVVRVVRVPRVPlplppRLLRSLAFLRRLRRLLRRERPDVVHAH 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487727424  113 GYSTNYFLYMLKKLdkngFGKVKTVITCHGWVEY--------NLKKKFLTYFDFWTYSMGDAFICVSETMKKRLES 180
Cdd:pfam13439  79 SPFPLGLAALAARL----RLGIPLVVTYHGLFPDykrlgarlSPLRRLLRRLERRLLRRADRVIAVSEAVADELRR 150
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 28-181 8.08e-10

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 56.78  E-value: 8.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424  28 IIVRYNNGHCGGIDPHIIGLCKKQIRRMslYPILIIVSRDSKVIDDYKNLDIAYVDCTQCSNNFETALHVKNI---LKLL 104
Cdd:cd03801    4 LLSPELPPPVGGAERHVRELARALAARG--HDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELrplLRLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424 105 KIRLIHCHGYSTNYFLYMLKKLDKngfgkVKTVITCHG------WVEYNLKKKFLTYFDFWtYSMGDAFICVSETMKKRL 178
Cdd:cd03801   82 KFDVVHAHGLLAALLAALLALLLG-----APLVVTLHGaepgrlLLLLAAERRLLARAEAL-LRRADAVIAVSEALRDEL 155


                 ...
gi 487727424 179 ESI 181
Cdd:cd03801  156 RAL 158
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 39-181 2.94e-08

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 51.98  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424  39 GIDPHIIGLCKKQIRRMSLYPILIIVSRDSKVIDDYKNLDIAYVdctqcsnnfetaLHVKNILKLLKIRLIHCHGYSTNY 118
Cdd:cd03811   29 GYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLLKAI------------LKLKRILKRAKPDVVISFLGFATY 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487727424 119 FLymlkklDKNGFGKVKTVITCHGWVEYNLKKKFLTYFDFWTYSMGDAFICVSETMKKRLESI 181
Cdd:cd03811   97 IV------AKLAAARSKVIAWIHSSLSKLYYLKKKLLLKLKLYKKADKIVCVSKGIKEDLIRL 153
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 26-184 2.64e-05

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 43.46  E-value: 2.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424  26 AHIIVRYNNGhcgGIDPHIIGLCKKQiRRMSLYPILIIVSRDSKVIDDYKNLDIAYVDCTQCSNNFETALhvkniLKLLK 105
Cdd:cd03807    3 AHVITGLNVG---GAETMLLRLLEHM-DKSRFEHVVISLTGDGVLGEELLAAGVPVVCLGLSSGKDPGVL-----LRLAK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424 106 IR------LIHCHGYSTNYFLYMLKKLdkngFGKVKTVITCHGWVEYNLKKKFLTYFDFWTYSMGDAFICVSETMKKRLE 179
Cdd:cd03807   74 LIrkrnpdVVHTWMYHADLIGGLAAKL----AGGVKVIWSVRSSNIPQRLTRLVRKLCLLLSKFSPATVANSSAVAEFHQ 149


                 ....*
gi 487727424 180 SIIKK 184
Cdd:cd03807  150 EQGYA 154
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
101-179 1.85e-03

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 37.00  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424  101 LKLLKIRLIHCHGYSTNyFLYMLKKLDKngfgKVKTVITCHGWV---EYNLKKKFLTYFDFWTYSMGDAFICVSETMKKR 177
Cdd:pfam13579  67 LRAERPDVVHAHSPTAG-LAARLARRRR----GVPLVVTVHGLAldyGSGWKRRLARALERRLLRRADAVVVVSEAEAEL 141


                  ..
gi 487727424  178 LE 179
Cdd:pfam13579 142 LR 143
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 38-179 3.51e-03

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 37.33  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487727424  38 GGIDPHIIGLCKKQIRRmsLYPILIIVSRDSKViDDYKNLDIAYVDCTqcSNNFETALHVKNILKLL---KIRLIHCHGY 114
Cdd:cd03819   11 GGAETYILDLARALAER--GHRVLVVTAGGPLL-PRLRQIGIGLPGLK--VPLLRALLGNVRLARLIrreRIDLIHAHSR 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487727424 115 STNYFLYMLKKLDkngfgKVKTVITCHG--WVEYNLKkkfltyfDFWTYSM--GDAFICVSETMKKRLE 179
Cdd:cd03819   86 APAWLGWLASRLT-----GVPLVTTVHGsyLATYHPK-------DFALAVRarGDRVIAVSELVRDHLI 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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