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Conserved domains on  [gi|487748693|ref|WP_001830713|]
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MULTISPECIES: SEFIR domain-containing protein [Staphylococcus]

Protein Classification

SEFIR domain-containing protein( domain architecture ID 10551222)

SEFIR domain-containing protein may function as signaling components of Toll/IL-1R-similar pathways and the SEFIR domain mediates physical protein-protein interactions between pathway components

CATH:  3.40.50.11530
PubMed:  12765832

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 2-116 1.10e-27

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


:

Pssm-ID: 254756  Cd Length: 150  Bit Score: 100.55  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748693    2 KNIFISYAWDKEND-EKVIKLAEMLEEYKELNVKFDKWDINK--GQEIPLFMEKEIQQSDFVLVICSN----RYKENTDK 74
Cdd:pfam08357   1 RKVFIVYSSDSALHtEVVLKFAEFLQDYCGCEVALDLWELNEiaEIGPVAWLERQIQEADKVIIVCSKgakaFCDKKADK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 487748693   75 RIGGSGYEARLMA-----NEIL----KNIDKDRFLPVLLNENDKDHIPNFL 116
Cdd:pfam08357  81 RKGGVGTESQHDLfipalSLILrdfkQSAALRKYLVVYFGYADKKDVPTIL 131
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 2-116 1.10e-27

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 100.55  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748693    2 KNIFISYAWDKEND-EKVIKLAEMLEEYKELNVKFDKWDINK--GQEIPLFMEKEIQQSDFVLVICSN----RYKENTDK 74
Cdd:pfam08357   1 RKVFIVYSSDSALHtEVVLKFAEFLQDYCGCEVALDLWELNEiaEIGPVAWLERQIQEADKVIIVCSKgakaFCDKKADK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 487748693   75 RIGGSGYEARLMA-----NEIL----KNIDKDRFLPVLLNENDKDHIPNFL 116
Cdd:pfam08357  81 RKGGVGTESQHDLfipalSLILrdfkQSAALRKYLVVYFGYADKKDVPTIL 131
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 2-116 1.10e-27

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 100.55  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748693    2 KNIFISYAWDKEND-EKVIKLAEMLEEYKELNVKFDKWDINK--GQEIPLFMEKEIQQSDFVLVICSN----RYKENTDK 74
Cdd:pfam08357   1 RKVFIVYSSDSALHtEVVLKFAEFLQDYCGCEVALDLWELNEiaEIGPVAWLERQIQEADKVIIVCSKgakaFCDKKADK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 487748693   75 RIGGSGYEARLMA-----NEIL----KNIDKDRFLPVLLNENDKDHIPNFL 116
Cdd:pfam08357  81 RKGGVGTESQHDLfipalSLILrdfkQSAALRKYLVVYFGYADKKDVPTIL 131
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 4-110 2.88e-17

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 73.12  E-value: 2.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748693    4 IFISYAWdkENDEKVIKLAEMLEEyKELNVKFDKWDINKGQEIPLFMEKEIQQSDFVLVICSNRYKENtdkriGGSGYEA 83
Cdd:pfam13676   1 VFISYAG--EDRAWAEWLADALEA-AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLES-----PWCRAEW 72

                          90       100
                  ....*....|....*....|....*..
gi 487748693   84 RLMANEILKNIdkdRFLPVLLNENDKD 110
Cdd:pfam13676  73 EAALADPEGRK---RLIPVRLECDLEL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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